免疫检查点抗体和蛋白
免疫检查点阻断抗体可通过增强免疫系统功能来与癌症作战，近年来这种癌症免疫疗法正成为治疗各类恶性肿瘤的重要方法之一。CTLA-4是第一个用于临床的免疫检查点靶点，其抑制剂ipilimumab在2011年批准上市。程序性死亡受体-1（PD-1）与其配体PD-L1，作为治疗恶性肿瘤的新靶点也有巨大潜力。今后多靶点联合用药将会给癌症治疗带来更好的疗效。
金斯瑞提供多种免疫检查点相关产品，包括抗体，蛋白和细胞系等，为您的免疫治疗研究助一臂之力。更多靶点的产品正在陆续上市。
免疫检查点抗体的应用
- 人源化抗体药物早期开发的阳性对照
- 替代抗体（小鼠抗小鼠抗体）
- 抗免疫检查点抗体药物抗体（抗独特型抗体）
订购信息（宿主：Rabbit）
相关产品
订购信息（宿主：Mouse）
候选药物的抗体（Drug candidate antibody）
- 抗体药物开发的阳性对照
- 制备细胞系
- 研究分析方法
Target
Cat.No.
Product Name
ELISA
FACS
Functional Assay
PD1
✔
✔
✔
PDL1
✔
✔
✔
抗独特型抗体（Anti-idiotype Antibody）
- 开发生物分析方法 (PK/PD)
- 免疫原性研究
Target
Drug Name
Cat.No
Product Name
Clone ID
Inhibitory,IC50((μg/ml)
Recommend Applications
PD-1
Pembrolizumab (Keytruda)
A01844-40
Anti-Pembrolizumab Antibody mAb, Mouse
1D6E10
Non-inhibitory
Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01845
A01845-40
Anti-Pembrolizumab Antibody [Biotin], mAb, Mouse
10E12C6
0.37
Direct/Inhibitory ELISA,Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01844
A01853-40
MonoRab™ Anti-Pembrolizumab Antibody [BIOTIN], mAb, Rabbit
90G12F8
0.38
Direct/Inhibitory ELISA, Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01852
A01846-40
Anti-Pembrolizumab Antibody, pAb, Rabbit
N/A
Direct ELISAImmunogenicity assay
Nivolumab (Opdivo)
A01847-40
Anti-Nivolumab Antibody, mAb, Mouse
8G6G3D8
Non-inhibitory
Indirect ELISA, Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40
A01848-40
Anti-Nivolumab Antibody [Biotin], mAb, Mouse
6G5H2E6
Non-inhibitory
Direct/Indirect ELISA,Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40
CTLA-4
Ipilimumab (Yervoy)
A01859-40
Anti-Ipilimumab Antibody, mAb, Mouse
26B6H7D9
Non-inhibitory
Indirect ELISA,Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40
A01858-40
Anti-Ipilimumab Antibody [Biotin], mAb, Mouse
4H6E1D4
Non-inhibitory
Direct/Indirect ELISA,Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40
| Target | Cat.No. | Product Name | ELISA | FACS | Functional Assay |
|---|---|---|---|---|---|
| PD1 | ✔ |
✔ |
✔ |
||
| PDL1 | ✔ |
✔ |
✔ |
| Target | Drug Name | Cat.No | Product Name | Clone ID | Inhibitory,IC50((μg/ml) | Recommend Applications |
|---|---|---|---|---|---|---|
| PD-1 | Pembrolizumab (Keytruda) | A01844-40 | Anti-Pembrolizumab Antibody mAb, Mouse | 1D6E10 | Non-inhibitory | Indirect ELISA,Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01845 |
| A01845-40 | Anti-Pembrolizumab Antibody [Biotin], mAb, Mouse | 10E12C6 | 0.37 | Direct/Inhibitory ELISA,Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01844 | ||
| A01853-40 | MonoRab™ Anti-Pembrolizumab Antibody [BIOTIN], mAb, Rabbit | 90G12F8 | 0.38 | Direct/Inhibitory ELISA, Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01852 | ||
| A01846-40 | Anti-Pembrolizumab Antibody, pAb, Rabbit | N/A | Direct ELISAImmunogenicity assay | |||
| Nivolumab (Opdivo) | A01847-40 | Anti-Nivolumab Antibody, mAb, Mouse | 8G6G3D8 | Non-inhibitory | Indirect ELISA, Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40 | |
| A01848-40 | Anti-Nivolumab Antibody [Biotin], mAb, Mouse | 6G5H2E6 | Non-inhibitory | Direct/Indirect ELISA,Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40 | ||
| CTLA-4 | Ipilimumab (Yervoy) | A01859-40 | Anti-Ipilimumab Antibody, mAb, Mouse | 26B6H7D9 | Non-inhibitory | Indirect ELISA,Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40 |
| A01858-40 | Anti-Ipilimumab Antibody [Biotin], mAb, Mouse | 4H6E1D4 | Non-inhibitory | Direct/Indirect ELISA,Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40 |
免疫检查点蛋白的应用
- 调节免疫反应
- 识别结合蛋白
- 发现新药
- 生产抗体
订购信息（注：以下靶点的蛋白产品即将上市）
靶点 |
产品货号 |
|---|---|
| Human PD-1 | Z03370 |
| Human PD-L1 | Z03371 |
| Human PD-L2 | Z03417 |
| Human PVR/CD155 | Z03435 |
| Human SIRPα | Z03420 |
| Human CTLA4 | Z03373 |
| Human CD19 | Z03407 |
| Human B7-2 | Z03416 |
| Human B7-H3 | Z03426 |
| Z03427 | |
| Human OX40 | Z03438 |
| Human TIM3 | Z03392 |
| Human CD137 | Z03382 |
| Human HVEM | Z03224 |
| Human CD40L | Z02022 |
| Human CD40L | Z02727 |
| Human CD80 | Z03409 |
| Human LAG3 | Z03422 |
| Mouse OX40 | Z03403 |
