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Engineered ipilimumab variants that bind human and mouse CTLA-4
Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee
Journal: MAbs
PubMed ID: 39849917
Doi: 10.1080/19420862.2025.2451296
Products & Services: Combinatorial DNA Libraries   
Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer
Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu
Journal: ACS Nano
PubMed ID: 40033785
Doi: 10.1021/acsnano.4c16698
Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy
Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang
Journal: J Am Chem Soc
PubMed ID: 40065259
Doi: 10.1021/jacs.4c18511
Products & Services: Recombinant Proteins   
GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint
Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang
Journal: Sci Adv
PubMed ID: 40043109
Doi: doi/10.1126/sciadv.adr9395
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo
Journal: Bone Res
PubMed ID: 40025004
Doi: 10.1038/s41413-024-00399-5
Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system
Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang
Journal: Nat Commun
PubMed ID: 39984501
Doi: 10.1038/s41467-025-57153-6
Products & Services: Gene Synthesis   
EXPERT expands prime editing efficiency and range of large fragment edits
Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan
Journal: Nat Commun
PubMed ID: 39939583
Doi: 10.1038/s41467-025-56734-9
Products & Services: Gene Synthesis   
Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy
Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma
Journal: Chemical Engineering Journal
Doi: 10.1016/j.cej.2025.160862
Products & Services: Peptide Synthesis   
Double antibody sandwich ELISA based on rabbit monoclonal antibody targeting gD protein for the detection of bovine herpesvirus 1
Authors: Qiang Liu, Xiaoxia Niu, Lingling Jiang, Gang Zhang, Pu Wang, Sinong Zhang, Weifeng Gao, Huichen Guo, Yujiong Wang, Yong Li
Journal: Int J Biol Macromol
PubMed ID: 39929469
Doi: 10.1016/j.ijbiomac.2025.140671
Products & Services: Gene Synthesis   

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