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Optimizing -Mediated Transformation and CRISPR-Cas9 Gene Editing in the Rice Variety Presidio

Authors: Marco Molina-Risco, Oneida Ibarra, Mayra Faion-Molina, Backki Kim, Endang M Septiningsih, Michael J Thomson

Journal: Int J Mol Sci

PubMed ID: 34681568

Doi: 10.3390/ijms222010909

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CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation

Authors: Xiaohan Mei, Xiao-Bing Cui, Yiran Li, Shi-You Chen

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34670409

Doi: 10.1161/ATVBAHA.121.316911

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A Novel Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase

Authors: Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Antonio Mattia Modarelli, Matteo Bertelli, Leonardo Colombo, Daniele Dell'Orco

Journal: Int J Mol Sci

PubMed ID: 34639157

Doi: 10.3390/ijms221910809

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The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Zachary C Elmore, L Patrick Havlik, Daniel K Oh, Leif Anderson, George Daaboul, Garth W Devlin, Heather A Vincent, Aravind Asokan

Journal: Nat Commun

PubMed ID: 34716331

Doi: 10.1038/s41467-021-26485-4

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Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1

Authors: Yan Li, Elizabeth YiHui Ng, Ying Ru Loh, Chong Yu Gea, Qiwei Huang, Qingxin Li, CongBao Kang

Journal: J Pept Sci

PubMed ID: 34713534

Doi: 10.1002/psc.3376

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De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Authors: Quanli Liu, Yi Liu, Gang Li, Otto Savolainen, Yun Chen, Jens Nielsen

Journal: Nat Commun

PubMed ID: 34667183

Doi: 10.1038/s41467-021-26361-1

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Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica

Authors: Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra

Journal: Insect Biochem Mol Biol

PubMed ID: 34656795

Doi: 10.1016/j.ibmb.2021.103671

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Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor

Authors: David Sybers, Amber Joka Bernauw, Diala El Masri, Hassan Ramadan Maklad, Daniel Charlier, Marjan De Mey, Indra Bervoets, Eveline Peeters

Journal: Gene

PubMed ID: 34688814

Doi: 10.1016/j.gene.2021.146010

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Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8 T-Cell Responses

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Wei-Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D Long, Fumito Ito, Scott I Abrams, Jonathan F Lovell

Journal: Adv Sci (Weinh)

PubMed ID: 34716694

Doi: 10.1002/advs.202103023

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Tuning Gene Expression by Phosphate in the Methanogenic Archaeon

Authors: Taiwo S Akinyemi, Nana Shao, Zhe Lyu, Ian J Drake, Yuchen Liu, William B Whitman

Journal: ACS Synth Biol

PubMed ID: 34665610

Doi: 10.1021/acssynbio.1c00322

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An Engineered Thermostable Laccase with Great Ability to Decolorize and Detoxify Malachite Green

Authors: Guotao Mao, Kai Wang, Fangyuan Wang, Hao Li, Hongsen Zhang, Hui Xie, Zhimin Wang, Fengqin Wang, Andong Song

Journal: Int J Mol Sci

PubMed ID: 34769185

Doi: 10.3390/ijms222111755

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Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

Authors: Mei Yang, Jiaqi Li, Zhaoxia Huang, Heng Li, Yueming Wang, Xiaoli Wang, Sisi Kang, Xing Huang, Changwen Wu, Tong Liu, Zhenxing Jia, Junlang Liang, Xiaohui Yuan, Suhua He, Xiaoxue Chen, Zhechong Zhou, Qiuyue Chen, Siqi Liu, Jing Li, Huiwen Zheng, Xi Liu, Kenan Li, Xiaojun Yao, Bin Lang, Longding Liu, Hua-Xin Liao, Shoudeng Chen

Journal: Microbiol Spectr

PubMed ID: 34643438

Doi: 10.1128/Spectrum.01352-21

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Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA

Authors: Anders Kokkenborg Varming, Kim Krighaar Rasmussen, Zhiyou Zong, Peter Waaben Thulstrup, Mogens Kilstrup, Leila Lo Leggio

Journal: FEBS J

PubMed ID: 34665941

Doi: 10.1111/febs.16238

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Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis Inhibition of AOC

Authors: Yumei Rong, Ge Hong, Na Zhu, Yang Liu, Yong Jiang, Tianjun Liu

Journal: Front Pharmacol

PubMed ID: 34744725

Doi: 10.3389/fphar.2021.746725

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Human antibody recognition of H7N9 influenza virus HA following natural infection

Authors: Iuliia M Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G Bombardi, Andrew Trivette, Sheng Li, Hannah L Turner, Robert H Carnahan, Andrew B Ward, James E Crowe

Journal: JCI Insight

PubMed ID: 34437301

Doi: 10.1172/jci.insight.152403

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Molecular Characterization of AMPA-Receptor-Containing Vesicles

Authors: John Jacob Peters, Jeremy Leitz, Juan A Oses-Prieto, Alma L Burlingame, Axel T Brunger

Journal: Front Mol Neurosci

PubMed ID: 34720876

Doi: 10.3389/fnmol.2021.754631

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Inhibition of receptor-binding domain-ACE2 interaction after two doses of Sinovac's CoronaVac or AstraZeneca/Oxford's AZD1222 SARS-CoV-2 vaccines

Authors: Valéria O Silva, Rosemeire Yamashiro, Cintia M Ahagon, Ivana B de Campos, Isabela P de Oliveira, Elaine L de Oliveira, Giselle I S López-Lopes, Elaine M Matsuda, Marcia J Castejon, Luís F de Macedo Brígido

Journal: J Med Virol

PubMed ID: 34647623

Doi: 10.1002/jmv.27396

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Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma

Authors: Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T Flaherty, Lee Zou, Hensin Tsao

Journal: J Invest Dermatol

PubMed ID: 34687746

Doi: 10.1016/j.jid.2021.07.188

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Quantitative comparison of different fluorescent dye-loaded nanoparticles

Authors: Guangze Yang, Yun Liu, Chun-Xia Zhao

Journal: Colloids Surf B Biointerfaces

PubMed ID: 34146992

Doi: doi.org/10.1016/j.colsurfb.2021.111923

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CRISPR/Cas12a-assisted rapid identification of key beer spoilage bacteria

Authors: Qingzhou Menga, Hongmei Yangb, Guiquan Zhangc, Wenjun Sund, Peixiang Mae, Xinyi Liuf, Lu Dangg, Guanglei Lid, Xingxu Huangd, Xinjie Wangh, Jianghuai Liuc, Qibin Lenga

Journal: Innovative Food Science and Emerging Technologies

Doi: 10.1016/j.ifset.2021.102854

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NIN-like protein transcription factors regulate leghemoglobin genes in legume nodules

Authors: Suyu Jiang, Marie-Françoise Jardinaud, Jinpeng Gao, Yann Pecrix, Jiangqi Wen,b Kirankumar Mysore, Ping Xu, Carmen Sanchez-Canizares, Yiting Ruan, Qiujiu Li, Meijun Zhu, Fuyu Li, Ertao Wang, Phillip S Poole, Pascal Gamas, Jeremy D Murray

Journal: Science

PubMed ID: 34709882

Doi: 10.1126/science.abg5945

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An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein

Authors: Narasimha Anaganti, Sujith Rajan, M Mahmood Hussain

Journal: J Lipid Res

PubMed ID: 34673018

Doi: 10.1016/j.jlr.2021.100136

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Construction and Analysis of a Yeast for the Simultaneous Release and Esterification of the Varietal Thiol 3-Sulfanylhexan-1-ol

Authors: Florian Kiene, Isak S Pretorius, Doris Rauhut, Christian von Wallbrunn, Niël van Wyk

Journal: J Agric Food Chem

PubMed ID: 34609136

Doi: 10.1021/acs.jafc.1c03976

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Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma

Authors: Sakiko Harada, Miki Ando, Jun Ando, Midori Ishii, Tomoyuki Yamaguchi, Satoshi Yamazaki, Tokuko Toyota, Kazuo Ohara, Manami Ohtaka, Mahito Nakanishi, Chansu Shin, Yasunori Ota, Kazutaka Nakashima, Koichi Ohshima, Chihaya Imai, Yozo Nakazawa, Hiromitsu Nakauchi, Norio Komatsu

Journal: Mol Ther

PubMed ID: 34628050

Doi: 10.1016/j.ymthe.2021.10.006

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TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

Authors: Matthias Liniger, Markus Gerber, Sandra Renzullo, Obdulio García-Nicolás, Nicolas Ruggli

Journal: Viruses

PubMed ID: 34696447

Doi: 10.3390/v13102017

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Corrigendum to "Rapid preparation of nanodiscs for biophysical studies" [Arch Biochem Biophys 712 (2021) 109051]

Authors: Jeffrey A Julien, Martin G Fernandez, Katrina M Brandmier, Joshua T Del Mundo, Carol M Bator, Lucie A Loftus, Esther W Gomez, Enrique D Gomez, Kerney Jebrell Glover

Journal: Arch Biochem Biophys

PubMed ID: 34756727

Doi: 10.1016/j.abb.2021.109073

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Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

Authors: Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang

Journal: J Med Chem

PubMed ID: 34668699

Doi: 10.1021/acs.jmedchem.1c01076

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Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Authors: Shuang-Zhou Peng, Xiao-Hui Chen, Si-Jie Chen, Jie Zhang, Chuan-Ying Wang, Wei-Rong Liu, Duo Zhang, Ying Su, Xiao-Kun Zhang

Journal: Nat Commun

PubMed ID: 34645818

Doi: 10.1038/s41467-021-26295-8

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Evidence of a shared binding site for Bacillus thuringiensis Cry1Ac and Cry2Aa toxins in Cnaphalocrocis medinalis cadherin

Authors: J Zhong, S Fang, M Gao, L Lu, X Zhang, Q Zhu, Y Liu, J L Jurat-Fuentes, X Liu

Journal: Insect Mol Biol

PubMed ID: 34637177

Doi: 10.1111/imb.12741

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Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways

Authors: Sean T Carey, Joshua M Gammon, Christopher M Jewell

Journal: Drug Deliv Transl Res

PubMed ID: 34611846

Doi: 10.1007/s13346-021-01075-5

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Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine

Authors: Danielle L Porier, Sarah N Wilson, Dawn I Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C Allen, Clayton C Caswell, James A Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C Weaver, Albert J Auguste

Journal: Vaccines (Basel)

PubMed ID: 34696250

Doi: 10.3390/vaccines9101142

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L-asparaginase from : expression, purification and cytotoxicity assessment

Authors: Hesham Saeed, Eman Elsawy, Manal Shalaby, Manal Abdel-Fattah, Asmaa Hemida, Ahmad Eldoksh, Farid Shokry Ataya, Hesham Nematalla, Mohamed Elkewedi, Nikolaos N Labrou, Nefertiti El-Nikhely

Journal: Prep Biochem Biotechnol

PubMed ID: 34612174

Doi: 10.1080/10826068.2021.1983831

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Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation

Authors: Patrick N Charron, Luis M Garcia, Irfan Tahir, Rachael A Floreani

Journal: J Mech Behav Biomed Mater

PubMed ID: 34736027

Doi: 10.1016/j.jmbbm.2021.104932

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A Novel Antimicrobial Peptide Sparamosin From the Mud Crab Showing Potent Antifungal Activity Against

Authors: Yan-Chao Chen, Ying Yang, Chang Zhang, Hui-Yun Chen, Fangyi Chen, Ke-Jian Wang

Journal: Front Microbiol

PubMed ID: 34690992

Doi: 10.3389/fmicb.2021.746006

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Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Authors: Xueyin Wang, Mark L Sandberg, Aaron D Martin, Kathleen R Negri, Grant B Gabrelow, Daniel P Nampe, Ming-Lun Wu, Michele E McElvain, Dora Toledo Warshaviak, Wen-Hua Lee, Julyun Oh, Mark E Daris, Falene Chai, Christine Yao, James Furney, Craig Pigott, Alexander Kamb, Han Xu

Journal: J Immunother

PubMed ID: 34432728

Doi: 10.1097/CJI.0000000000000386

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Marked Increase in Tumor Transfection with a Truncated Branched Polymer

Authors: Songhui Xu, Jiaxi He, Zuha Imtiyaz, Atul K Agrawal, Martin C Woodle, A James Mixson

Journal: J Gene Med

PubMed ID: 34713552

Doi: 10.1002/jgm.3396

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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Enhanced bone regeneration via spatiotemporal and controlled delivery ofa genetically engineered BMP-2 in a composite Hydrogel

Authors: Xin Chen , Baoyu Tan , Zhiteng Bao , Shang Wang , Rongze Tang , Zhenmin Wang , Gaoyang Chen , Shuai Chen , William W Lu , Dazhi Yang , Songlin Peng

Journal: Biomaterials

PubMed ID: 34517277

Doi: doi.org/10.1016/j.biomaterials.2021.121117

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Prior infection and age impacts antibody persistence after SARS-CoV-2 mRNA vaccine

Authors: Elizabeth Fraley, Cas LeMaster, Santosh Khanal, Dithi Banerjee, Tomi Pastinen, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

Journal: Clin Infect Dis

PubMed ID: 34551091

Doi: 10.1093/cid/ciab850

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Prior infection and age impacts antibody persistence after SARS-CoV-2 mRNA vaccine

Authors: Elizabeth Fraley, Cas LeMaster, Santosh Khanal, Dithi Banerjee, Tomi Pastinen, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

Journal: Clin Infect Dis

PubMed ID: 34551091

Doi: 10.1093/cid/ciab850

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Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Ovalbumin-Specific Cell Mediated Immunity in Mice Model

Authors: So Yeon Ahn, Chau Thuy Tien Le, Eun-Ju Ko

Journal: Biology (Basel)

PubMed ID: 34571785

Doi: 10.3390/biology10090908

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Marburg and Ebola Virus mRNA 3' Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing

Authors: Sudip Khadka, Caroline G Williams, Joyce Sweeney-Gibbons, Christopher F Basler

Journal: J Virol

PubMed ID: 34346762

Doi: 10.1128/JVI.00652-21

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Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Authors: Yuanling Yu, Meiyu Wang, Xiaoai Zhang, Shufen Li, Qingbin Lu, Haolong Zeng, Hongyan Hou, Hao Li, Mengyi Zhang, Fei Jiang, Jiajing Wu, Ruxia Ding, Zehua Zhou, Min Liu, Weixue Si, Tao Zhu, Hangwen Li, Jie Ma, Yuanyuan Gu, Guangbiao She, Xiaokun Li, Yulan Zhang, Ke Peng, Weijin Huang, Wei Liu, Youchun Wang

Journal: Signal Transduct Target Ther

PubMed ID: 34561414

Doi: 10.1038/s41392-021-00759-1

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Hinge influences in murine IgG binding to Cryptococcus neoformans capsule

Authors: Diane Sthefany Lima de Oliveira, Verenice Paredes, Adrielle Veloso Caixeta, Nicole Moreira Henriques, Maggie P Wear, Patrícia Albuquerque, Maria Sueli Soares Felipe, Arturo Casadevall, André Moraes Nicola

Journal: Immunology

PubMed ID: 34458991

Doi: 10.1111/imm.13411

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Molecular and Enzymatic Characterization of Flavonoid 3'-Hydroxylase of ×

Authors: Julia Weissensteiner, Christian Molitor, Silvija Marinovic, Lisa Führer, Syed Waqas Hassan, Olly Sanny Hutabarat, Andreas Spornberger, Karl Stich, Johanna Hausjell, Oliver Spadiut, Christian Haselmair-Gosch, Heidi Halbwirth

Journal: Plants (Basel)

PubMed ID: 34579488

Doi: 10.3390/plants10091956

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FGF21 ameliorates hepatic fibrosis by multiple mechanisms

Authors: Fanrui Meng, Mir Hassan Khoso, Kai Kang, Qi He, Yukai Cao, Xinghao Jiang, Wei Xiao, Deshan Li

Journal: Mol Biol Rep

PubMed ID: 34536190

Doi: 10.1007/s11033-021-06707-0

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Novel Antimicrobial Peptides from a Cecropin-Like Region of Heteroscorpine-1 from Venom with Membrane Disruption Activity

Authors: Rima Erviana, Yutthakan Saengkun, Prapenpuksiri Rungsa, Nisachon Jangpromma, Patcharaporn Tippayawat, Sompong Klaynongsruang, Jureerut Daduang, Sakda Daduang

Journal: Molecules

PubMed ID: 34641415

Doi: 10.3390/molecules26195872

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Tissue-Resident-Memory CD8 T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes

Authors: Tao Peng, Khamsone Phasouk, Catherine N Sodroski, Sijie Sun, Yon Hwangbo, Erik D Layton, Lei Jin, Alexis Klock, Kurt Diem, Amalia S Magaret, Lichen Jing, Kerry Laing, Alvason Li, Meei-Li Huang, Max Mertens, Christine Johnston, Keith R Jerome, David M Koelle, Anna Wald, David M Knipe, Lawrence Corey, Jia Zhu

Journal: Front Immunol

PubMed ID: 34552595

Doi: 10.3389/fimmu.2021.735643

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Lipopolysaccharide Is a 4-Aminoarabinose Donor to Exogenous Polyisoprenyl Phosphates through the Reverse Reaction of the Enzyme ArnT

Authors: Beth A Scarbrough, Colleen R Eade, Amanda J Reid, Tiffany C Williams, Jerry M Troutman

Journal: ACS Omega

PubMed ID: 34632229

Doi: 10.1021/acsomega.1c04036

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Resistance of SARS-CoV-2 Delta variant to neutralization by BNT162b2-elicited antibodies in Asians

Authors: Bei Wang, Yun Shan Goh, Siew-Wai Fong, Barnaby Edward Young, Eve Zi Xian Ngoh, Jean-Marc Chavatte, Siti Nazihah Mohd Salleh, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Pei Xiang Hor, Chiew Yee Loh, Chia Yin Lee, Yi-Hao Chan, Zi Wei Chang, Matthew Zirui Tay, Angeline Rouers, Anthony Torres-Ruesta, Guillaume Carissimo, Mun Kuen Soh, Raphael Tze Chuen Lee, Yani Xu, Surinder Pada, Raymond Tzer Pin Lin, Yee-Sin Leo, David C Lye, Sebastian Maurer-Stroh, Lisa F P Ng, Laurent Renia, Cheng-I Wang

Journal: Lancet Reg Health West Pac

PubMed ID: 34568853

Doi: 10.1016/j.lanwpc.2021.100276

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Expression of Biofilm-Degrading Enzymes in Plants and Automated High-Throughput Activity Screening Using Experimental Biofilms

Authors: P Opdensteinen, S J Dietz, B B Gengenbach, J F Buyel

Journal: Front Bioeng Biotechnol

PubMed ID: 34621728

Doi: 10.3389/fbioe.2021.708150

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Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

Authors: Delia Susan-Resiga, Emmanuelle Girard, Rachid Essalmani, Anna Roubtsova, Jadwiga Marcinkiewicz, Rabeb M Derbali, Alexandra Evagelidis, Jae H Byun, Paul F Lebeau, Richard C Austin, Nabil G Seidah

Journal: J Biol Chem

PubMed ID: 34508778

Doi: 10.1016/j.jbc.2021.101177

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Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton

Authors: Katharina Vestre, Irene Persiconi, Marita Borg Distefano, Nadia Mensali, Noemi Antonella Guadagno, Marine Bretou, Sébastien Wälchli, Catharina Arnold-Schrauf, Oddmund Bakke, Marc Dalod, Ana-Maria Lennon-Dumenil, Cinzia Progida

Journal: J Cell Sci

PubMed ID: 34494097

Doi: 10.1242/jcs.259221

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Genome-wide identification, evolution, and transcript profiling of Aldehyde dehydrogenase superfamily in potato during development stages and stress conditions

Authors: Md Sifatul Islam, Md Soyib Hasan, Md Nazmul Hasan, Shamsul H Prodhan, Tahmina Islam, Ajit Ghosh

Journal: Sci Rep

PubMed ID: 34521910

Doi: 10.1038/s41598-021-97691-9

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Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted

Authors: Jeremy D Rubinstein, Xiang Zhu, Thomas Leemhuis, Giang Pham, Lorraine Ray, Sana Emberesh, Sonata Jodele, Shawn Thomas, Jose A Cancelas, Catherine M Bollard, Patrick J Hanley, Michael D Keller, Olivia Grimley, Diana Clark, Teri Clark, Cecilia S Lindestam Arlehamn, Alessandro Sette, Stella M Davies, Adam S Nelson, Michael S Grimley, Carolyn Lutzko

Journal: Blood Adv

PubMed ID: 34473237

Doi: 10.1182/bloodadvances.2021004456

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Safety and efficacy of an engineered hepatotropic AAV gene therapy for ornithine transcarbamylase deficiency in cynomolgus monkeys

Authors: Julien Baruteau, Sharon C Cunningham, Berna Seker Yilmaz, Dany P Perocheau, Simon Eaglestone, Derek Burke, Adrian J Thrasher, Simon N Waddington, Leszek Lisowski, Ian E Alexander, Paul Gissen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34703837

Doi: 10.1016/j.omtm.2021.09.005

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A Peptide-Based Assay Discriminates Individual Antibody Response to the COVID-19 Pfizer/BioNTech mRNA Vaccine

Authors: Immacolata Polvere, Serena Voccola, Alfredina Parrella, Gaetano Cardinale, Lucrezia Zerillo, Romualdo Varricchio, Jessica Raffaella Madera, Romania Stilo, Pasquale Vito, Tiziana Zotti

Journal: Vaccines (Basel)

PubMed ID: 34579224

Doi: 10.3390/vaccines9090987

Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells

Authors: Li Huang, Jing Ma, Min Cui

Journal: Immunol Res

PubMed ID: 34559381

Doi: 10.1007/s12026-021-09237-w

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MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3

Authors: Lei Zhang, Jianjun Qiu, Jixiang Shi, Shaoyang Liu, Hanlin Zou

Journal: Bioengineered

PubMed ID: 34565303

Doi: 10.1080/21655979.2021.1985342

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Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors

Authors: Hong Liu, Anneng Yang, Jiajun Song, Naixiang Wang, Puiyiu Lam, Yuenling Li, Helen Ka-Wai Law, Feng Yan

Journal: Sci Adv

PubMed ID: 34524851

Doi: 10.1126/sciadv.abg8387

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Loss of Function of and in Rice Promotes Early Maturing and Semi-Dwarfism in γ-Irradiated IWP and Genome-Edited Pusa Basmati-1

Authors: M T Andrew-Peter-Leon, Ramchander Selvaraj, K K Kumar, Mehanathan Muthamilarasan, Jeshima Khan Yasin, M Arumugam Pillai

Journal: Front Plant Sci

PubMed ID: 34630462

Doi: 10.3389/fpls.2021.714066

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An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam

Authors: Nguyen Van Vinh Chau, Nghiem My Ngoc, Lam Anh Nguyet, Vo Minh Quang, Nguyen Thi Han Ny, Dao Bach Khoa, Nguyen Thanh Phong, Le Mau Toan, Nguyen Thi Thu Hong, Nguyen Thi Kim Tuyen, Voong Vinh Phat, Le Nguyen Truc Nhu, Nguyen Huynh Thanh Truc, Bui Thi Ton That, Huynh Phuong Thao, Tran Nguyen Phuong Thao, Vo Trong Vuong, Tran Thi Thanh Tam, Ngo Tan Tai, Ho The Bao, Huynh Thi Kim Nhung, Nguyen Thi Ngoc Minh, Nguyen Thi My Tien, Nguy Cam Huy, Marc Choisy, Dinh Nguyen Huy Man, Dinh Thi Bich Ty, Nguyen To Anh, Le Thi Tam Uyen, Tran Nguyen Hoang Tu, Lam Minh Yen, Nguyen Thanh Dung, Le Manh Hung, Nguyen Thanh Truong, Tran Tan Thanh, Guy Thwaites, Le Van Tan

Journal: EClinicalMedicine

PubMed ID: 34608454

Doi: 10.1016/j.eclinm.2021.101143

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Glycosylation reduces the glycan-independent immunomodulatory effect of recombinant Orysata lectin in Drosophila S2 cells

Authors: Pengyu Chen, Kristof De Schutter, Sonia Serna, Simin Chen, Qun Yang, Niels-Christian Reichardt, Els J M Van Damme, Guy Smagghe

Journal: Sci Rep

PubMed ID: 34504130

Doi: 10.1038/s41598-021-97161-2

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Plant-Expressed Receptor Binding Domain of the SARS-CoV-2 Spike Protein Elicits Humoral Immunity in Mice

Authors: Puna Maya Maharjan, Jinyeong Cheon, Jiyun Jung, Haerim Kim, Jaewon Lee, Minjeong Song, Gi Uk Jeong, Youngchan Kwon, Byoungshik Shim, Sunghwa Choe

Journal: Vaccines (Basel)

PubMed ID: 34579215

Doi: 10.3390/vaccines9090978

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Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal integration

Authors: Siqi Yang, Yiwen Zhang, Jiaqi Xu, Jiao Zhang, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang

Journal: Nucleic Acids Res

PubMed ID: 34478496

Doi: 10.1093/nar/gkab752

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Regulation of human mTOR complexes by DEPTOR

Authors: Matthias Wälchli, Karolin Berneiser, Francesca Mangia, Stefan Imseng, Louise-Marie Craigie, Edward Stuttfeld, Michael N Hall, Timm Maier

Journal: Elife

PubMed ID: 34519268

Doi: 10.7554/eLife.70871

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Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: medrxiv

PubMed ID: 34611671

Doi: 10.1101/2021.09.27.21264000

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Analytical and clinical performance of cPass neutralizing antibodies assay

Authors: Joanna Jung, Deepthi Rajapakshe, Christopher Julien, Sridevi Devaraj

Journal: Clin Biochem

PubMed ID: 34560062

Doi: 10.1016/j.clinbiochem.2021.09.008

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Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling

Authors: Vindya Ramanayake-Mudiyanselage, D Maheeka Embogama, Mary Kay H Pflum

Journal: J Proteome Res

PubMed ID: 34491762

Doi: 10.1021/acs.jproteome.1c00562

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A Small Cysteine-Rich Phytotoxic Protein of Functions as Both Plant Defense Elicitor and Virulence Factor

Authors: Zi-Hui Zhang, Jing-Hao Jin, Gui-Lin Sheng, Yu-Ping Xing, Wang Liu, Xue Zhou, Yi-Qing Liu, Xiao-Ren Chen

Journal: Mol Plant Microbe Interact

PubMed ID: 33819070

Doi: 10.1094/MPMI-01-21-0025-R

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A Closer Look into FDA-EUA Approved Diagnostic Techniques of Covid-19

Authors: Hyunju Oh, Hyunjeong Ahn, Anubhav Tripathi

Journal: ACS Infect Dis

PubMed ID: 34569778

Doi: 10.1021/acsinfecdis.1c00268

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Consumption of gossypol increases fatty acid-amino acid conjugates in the cotton pests Helicoverpa armigera and Heliothis virescens

Authors: Corinna Krempl, Nicole Joußen, Michael Reichelt, Marco Kai, Heiko Vogel, David G Heckel

Journal: Arch Insect Biochem Physiol

PubMed ID: 34490676

Doi: 10.1002/arch.21843

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Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway

Authors: Jenan Al-Matouq, Latifa Al-Haj, Maher Al-Saif, Khalid S A Khabar

Journal: Oncogenesis

PubMed ID: 34535639

Doi: 10.1038/s41389-021-00351-w

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Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition

Authors: Amanda L Mohabeer, Jeffrey T Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J Broekelmann, Guangpei Hou, Hangjun Zhang, Yu-Qing Zhou, Minyao Wang, Anthony O Gramolini, Robert P Mecham, Scott P Heximer, Steffen-Sebastian Bolz, Michelle P Bendeck

Journal: Matrix Biol Plus

PubMed ID: 34693248

Doi: 10.1016/j.mbplus.2021.100085

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ReScribe: An Unrestrained Tool Combining Multiplex Recombineering and Minimal-PAM ScCas9 for Genome Recoding

Authors: Enrique Asin-Garcia, Maria Martin-Pascual, Luis Garcia-Morales, Richard van Kranenburg, Vitor A P Martins Dos Santos

Journal: ACS Synth Biol

PubMed ID: 34547891

Doi: 10.1021/acssynbio.1c00297

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MicroRNA-361 reduces the viability and migratory ability of pancreatic cancer cells via mediation of the MAPK/JNK pathway

Authors: Juan Wang, Zongjing Xie, Yan Liu, Weiguo Zhang, Tingting Ji

Journal: Exp Ther Med

PubMed ID: 34659511

Doi: 10.3892/etm.2021.10799

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Yeast Translational Activator Mss51p and Human ZMYND17 - Two Proteins with a Common Origin, but Different Functions

Authors: Maria V Baleva, Uliyana E Piunova, Ivan V Chicherin, Darya G Krasavina, Sergey A Levitskii, Piotr A Kamenski

Journal: Biochemistry (Mosc)

PubMed ID: 34565318

Doi: 10.1134/S0006297921090108

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Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase

Authors: Xida Zhao, Jingbo Liu, Chong Zhang, Ning Yu, Ze Lu, Shuwei Zhang, Yuchao Li, Qian Li, Junchao Liu, Dongjuan Liu, Yaping Pan

Journal: Int J Oral Sci

PubMed ID: 34593756

Doi: 10.1038/s41368-021-00136-2

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CLE14 functions as a "brake signal" to suppress age-dependent and stress-induced leaf senescence by promoting JUB1-mediated ROS scavenging in Arabidopsis

Authors: Zenglin Zhang, Cheng Liu, Kui Li, Xiaoxu Li, Mengmeng Xu, Yongfeng Guo

Journal: Mol Plant

PubMed ID: 34530165

Doi: 10.1016/j.molp.2021.09.006

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Enhancing Antigen Presentation and Inducing Antigen-Specific Immune Tolerance with Amphiphilic Peptides

Authors: Meng Li, Arata Itoh, Jingchao Xi, Chunsong Yu, Yuehong Wu, William M Ridgway, Haipeng Liu

Journal: J Immunol

PubMed ID: 34526376

Doi: 10.4049/jimmunol.1901301

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Characterization of HLA-A*02:01 MHC Immunopeptide Antigens Enhanced by Ultraviolet Photodissociation Mass Spectrometry

Authors: Eleanor Watts, Gregory K Potts, Damien B Ready, Alayna M George Thompson, Janice Lee, Edwin E Escobar, Melanie J Patterson, Jennifer S Brodbelt

Journal: Anal Chem

PubMed ID: 34553926

Doi: 10.1021/acs.analchem.1c01002

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Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Authors: Zetian Shen, Han Zhou, Aomei Li, Tiancong Wu, Xiaoqin Ji, Lei Guo, Xixu Zhu, Dagan Zhang, Xia He

Journal: Aging (Albany NY)

PubMed ID: 34546972

Doi: 10.18632/aging.203464

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Bioinformatics Analysis of a Functional ANGPT1 Variant That Interferes with miR-607 and Its Association with Susceptibility and Outcome of Ischemic Stroke in a Han Population

Authors: Ai-Nian Chen, Ling-Ling Zhong, Ke-Ju Ju, Hua Cao

Journal: Ther Clin Risk Manag

PubMed ID: 34611404

Doi: 10.2147/TCRM.S328964

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A Single Dose of a Hybrid hAdV5-Based Anti-COVID-19 Vaccine Induces a Long-Lasting Immune Response and Broad Coverage against VOC

Authors: M Verónica López, Sabrina E Vinzón, Eduardo G A Cafferata, Felipe J Núñez, Ariadna Soto, Maximiliano Sanchez-Lamas, M Jimena Afonso, Diana Aguilar-Cortes, Gregorio D Ríos, Juliana T Maricato, Carla T Braconi, Vanessa B Silveira, Tatiane M Andrad, Tatiana C S Bonetti, Luiz M Ramos Janini, Manoel J B C Girão, Andrea S Llera, Karina A Gomez, Hugo H Ortega, Paula M Berguer, Osvaldo L Podhajcer

Journal: Vaccines (Basel)

PubMed ID: 34696219

Doi: 10.3390/vaccines9101106

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ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling Elevating Suppressor of Cytokine Signaling 1

Authors: Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu

Journal: Front Microbiol

PubMed ID: 34650546

Doi: 10.3389/fmicb.2021.752597

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Plant Viral Nanoparticle Conjugated with Anti-PD-1 Peptide for Ovarian Cancer Immunotherapy

Authors: Aayushma Gautam, Veronique Beiss, Chao Wang, Lu Wang, Nicole F Steinmetz

Journal: Int J Mol Sci

PubMed ID: 34575893

Doi: 10.3390/ijms22189733

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The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer

Authors: Dianne J Beveridge, Kirsty L Richardson, Michael R Epis, Rikki A M Brown, Lisa M Stuart, Andrew J Woo, Peter J Leedman

Journal: Sci Rep

PubMed ID: 34504167

Doi: 10.1038/s41598-021-97190-x

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Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder

Authors: Luke Kowal, Jianhe Huang, Hongbin Luo, Jagmohan Singh, Adam E Snook, Jouni Uitto, Qiaoli Li

Journal: J Invest Dermatol

PubMed ID: 34597610

Doi: 10.1016/j.jid.2021.08.435

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complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Authors: Shinichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J Fowler, Tetsuhiro Yasuma, Shuichiro Hirahara, Reo Yasuma, Peirong Huang, Praveen Yerramothu, Ryan D Makin, Mo Wang, Kirstie L Baker, Kenneth M Marion, Xiwen Huang, Elmira Baghdasaryan, Meenakshi Ambati, Vidya L Ambati, Daipayan Banerjee, Vera L Bonilha, Genrich V Tolstonog, Ulrike Held, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Deepak Bhattarai, Kyung Bo Kim, Sanford H Feldman, J Ignacio Aguirre, David R Hinton, Nagaraj Kerur, Srinivas R Sadda, Gerald G Schumann, Bradley D Gelfand, Jayakrishna Ambati

Journal: Sci Adv

PubMed ID: 34586848

Doi: 10.1126/sciadv.abj3658

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TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

Authors: Suyan Wang, Mengmeng Yu, Aijing Liu, Yuanling Bao, Xiaole Qi, Li Gao, Yuntong Chen, Peng Liu, Yulong Wang, Lixiao Xing, Lingzhai Meng, Yu Zhang, Linjin Fan, Xinyi Li, Qing Pan, Yanping Zhang, Hongyu Cui, Kai Li, Changjun Liu, Xijun He, Yulong Gao, Xiaomei Wang

Journal: PLoS Pathog

PubMed ID: 34516573

Doi: 10.1371/journal.ppat.1009900

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CCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production

Authors: Nan Liang, Ming-Dong Yao, Ying Wang, Jia Liu, Lu Feng, Zhi-Ming Wang, Xiang-Yu Li, Wen-Hai Xiao, Ying-Jin Yuan

Journal: J Agric Food Chem

PubMed ID: 34554747

Doi: 10.1021/acs.jafc.1c04588

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Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

Authors: Laura T Gray, Michal M Raczy, Priscilla S Briquez, Tiffany M Marchell, Aaron T Alpar, Rachel P Wallace, Lisa R Volpatti, Maria Stella Sasso, Shijie Cao, Mindy Nguyen, Aslan Mansurov, Erica Budina, Elyse A Watkins, Ani Solanki, Nikolaos Mitrousis, Joseph W Reda, Shann S Yu, Andrew C Tremain, Ruyi Wang, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Balaji Manicassamy, Glenn Randall, D Scott Wilson, Marcin Kwissa, Melody A Swartz, Jeffrey A Hubbell

Journal: Biomaterials

PubMed ID: 34634664

Doi: 10.1016/j.biomaterials.2021.121159

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Polydopamine nanoparticles with different sizes for NIR-promoted gene delivery and synergistic photothermal therapy

Authors: Peng Zhang, Xinfang Li, Qinan Xu, Youxiang Wang, Jian Ji

Journal: Colloids Surf B Biointerfaces

PubMed ID: 34601352

Doi: 10.1016/j.colsurfb.2021.112125

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Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers

Authors: I Gusti Md Gde Surya C Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S Don, George Qian Li, Jane R Hanrahan, Yanfei Qi

Journal: Front Oncol

PubMed ID: 34604081

Doi: 10.3389/fonc.2021.738078

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Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU

Authors: Lorena Vigón, Javier García-Pérez, Sara Rodríguez-Mora, Montserrat Torres, Elena Mateos, María Castillo de la Osa, Miguel Cervero, Rosa Malo De Molina, Cristina Navarro, María Aránzazu Murciano-Antón, Valentín García-Gutiérrez, Vicente Planelles, José Alcamí, Mayte Pérez-Olmeda, Mayte Coiras, María Rosa López-Huertas

Journal: Front Immunol

PubMed ID: 34616404

Doi: 10.3389/fimmu.2021.742631

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