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Antibodies induced by oral immunization of mice with a recombinant protein produced in tobacco plants harboring epitopes

Authors: Karla Sanchez-Alvarez, Sergio Rosales-Mendoza, Karen L Reyes-Barrera, Leticia Moreno-Fierros, Ruth E Soria-Guerra, Rosalba Castillo-Collazo, Elizabeth Monreal-Escalente, Angel G Alpuche-Solis

Journal: Plant Cell Tissue Organ Cult

PubMed ID: 34276113

Doi: 10.1007/s11240-021-02107-1

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Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

Authors: Nadine G Rouphael, Lilin Lai, Sonia Tandon, Michele Paine McCullough, Yunchuan Kong, Sarah Kabbani, Muktha S Natrajan, Yongxian Xu, Yerun Zhu, Dongli Wang, Jesse O'Shea, Amy Sherman, Tianwei Yu, Sebastien Henry, Devin McAllister, Daniel Stadlbauer, Surender Khurana, Hana Golding, Florian Krammer, Mark J Mulligan, Mark R Prausnitz

Journal: npj Vaccines

PubMed ID: 34262052

Doi: 10.1038/s41541-021-00353-0

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Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Authors: Joana Barros-Martins, Swantje I Hammerschmidt, Anne Cossmann, Ivan Odak, Metodi V Stankov, Gema Morillas Ramos, Alexandra Dopfer-Jablonka, Annika Heidemann, Christiane Ritter, Michaela Friedrichsen, Christian Schultze-Florey, Inga Ravens, Stefanie Willenzon, Anja Bubke, Jasmin Ristenpart, Anika Janssen, George Ssebyatika, Günter Bernhardt, Jan Münch, Markus Hoffmann, Stefan Pöhlmann, Thomas Krey, Berislav Bošnjak, Reinhold Förster, Georg M N Behrens

Journal: Nat Med

PubMed ID: 34262158

Doi: 10.1038/s41591-021-01449-9

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A human apolipoprotein L with detergent-like activity kills intracellular pathogens

Authors: Ryan G Gaudet, Shiwei Zhu, Anushka Halder, Bae-Hoon Kim, Clinton J Bradfield, Shuai Huang, Dijin Xu, Agnieszka Mamiñska, Thanh Ngoc Nguyen, Michael Lazarou, Erdem Karatekin, Kallol Gupta, John D MacMicking

Journal: Science

PubMed ID: 34437126

Doi: 10.1126/science.abf8113

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Effects of Lipidation on a Proline-Rich Antibacterial Peptide

Authors: Federica Armas, Adriana Di Stasi, Mario Mardirossian, Antonello A Romani, Monica Benincasa, Marco Scocchi

Journal: Int J Mol Sci

PubMed ID: 34360723

Doi: 10.3390/ijms22157959

Products & Services: Bacterial Expression

Essential gene acquisition destabilizes plasmid inheritance

Authors: Tanita Wein, Yiqing Wang, Myriam Barz, Fenna T Stücker, Katrin Hammerschmidt, Tal Dagan

Journal: PLoS Genet

PubMed ID: 34252089

Doi: 10.1371/journal.pgen.1009656

Products & Services: Bacterial Expression

A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade

Authors: John O DaSilva, Katie Yang, Oliver Surriga, Thomas Nittoli, Arthur Kunz, Matthew C Franklin, Frank J Delfino, Shu Mao, Feng Zhao, Jason T Giurleo, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, Pamela Krueger, Randi Foster, Zhaoyuan Chen, Marc W Retter, Rabih Slim, Tara M Young, William C Olson, Gavin Thurston, Christopher Daly

Journal: Mol Cancer Ther

PubMed ID: 34315762

Doi: 10.1158/1535-7163.MCT-21-0009

CTS tag-based methods for investigating mitochondrial RNA modification factors in Trypanosoma brucei

Authors: Inna Aphasizheva, Takuma Suematsu, Andres Vacas, Hong Wang, Chenyu Fan, Xiaojing Zhao, Liye Zhang, Ruslan Aphasizhev

Journal: Methods Enzymol

PubMed ID: 34517961

Doi: 10.1016/bs.mie.2021.06.004

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Tight Interplay between Replication Stress and Competence Induction in

Authors: Vanessa Khemici, Marc Prudhomme, Patrice Polard

Journal: Cells

PubMed ID: 34440707

Doi: 10.3390/cells10081938

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Purification and HDL-like particle formation of apolipoprotein A-I after co-expression with the EDDIE mutant of Npro autoprotease

Authors: Rebecca Frankel, Katja Bernfur, Emma Sparr, Sara Linse

Journal: Protein Expr Purif

PubMed ID: 34298139

Doi: 10.1016/j.pep.2021.105946

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PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

Authors: Manikandan Samidurai, Bharathi N Palanisamy, Alejandra Bargues-Carot, Monica Hepker, Naveen Kondru, Sireesha Manne, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasamy

Journal: Front Aging Neurosci

PubMed ID: 34276337

Doi: 10.3389/fnagi.2021.661505

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Iron Oxidation by a Fused Cytochrome-Porin Common to Diverse Iron-Oxidizing Bacteria

Authors: Jessica L Keffer, Sean M McAllister, Arkadiy I Garber, Beverly J Hallahan, Molly C Sutherland, Sharon Rozovsky, Clara S Chan

Journal: MBio

PubMed ID: 34311573

Doi: 10.1128/mBio.01074-21

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Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε

Authors: Zifeng Zheng, Yuncheng Li, Mudan Zhang, Yalan Liu, Ming Fu, Sitang Gong, Qinxue Hu

Journal: Front Microbiol

PubMed ID: 34335514

Doi: 10.3389/fmicb.2021.687933

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Isolation and characterization of porcine monoclonal antibodies revealed two distinct serotype-independent epitopes on VP2 of foot-and-mouth disease virus

Authors: Kun Li, Guoqiang Zhu, Shasha Zhou, Pu Sun, Hengmei Wang, Huifang Bao, Yuanfang Fu, Pinghua Li, Xingwen Bai, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Zaixin Liu, Yimei Cao, Zengjun Lu

Journal: J Gen Virol

PubMed ID: 34280085

Doi: 10.1099/jgv.0.001608

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Aberrant Autophagy Impacts Growth and Multicellular Development in a Knockout Model of CLN5 Disease

Authors: Meagan D McLaren, Sabateeshan Mathavarajah, William D Kim, Shyong Q Yap, Robert J Huber

Journal: Front Cell Dev Biol

PubMed ID: 34291044

Doi: 10.3389/fcell.2021.657406

Products & Services: Proteins, Expression, Isolation and Analysis

A plant CitPITP1 protein-coding exon sequence serves as a promoter in bacteria

Authors: Qingjiang Wu, Jialing Fu, Juan Sun, Xia Wang, Xiaomei Tang, Wenjia Lu, Chen Tan, Li Li, Xiuxin Deng, Qiang Xu

Journal: J Biotechnol

PubMed ID: 34298024

Doi: 10.1016/j.jbiotec.2021.07.011

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Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein

Authors: Devivasha Bordoloi, Ziyang Xu, Michelle Ho, Mansi Purwar, Pratik Bhojnagarwala, Joel Cassel, Leila B Giron, Susanne Walker, Abhijeet J Kulkarni, Edgar Tello Ruiz, Jihae Choi, Faraz I Zaidi, Yuanhan Wu, Shaoying Wang, Ami Patel, Stephanie Ramos, Trevor Smith, Daniel Kulp, Kenneth E Ugen, Alagarsamy Srinivasan, Mohamed Abdel-Mohsen, Laurent Humeau, David B Weiner, Kar Muthumani

Journal: ACS Pharmacol Transl Sci

PubMed ID: 34396059

Doi: 10.1021/acsptsci.1c00058

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Molecular Characterization of Carbonic Anhydrase Genes in and Their Potential Roles in Symbiotic Nitrogen Fixation

Authors: Longlong Wang, Jianjun Liang, Yu Zhou, Tao Tian, Baoli Zhang, Deqiang Duanmu

Journal: Int J Mol Sci

PubMed ID: 34360533

Doi: 10.3390/ijms22157766

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Comparing the relative robustness of anion exchange and the corresponding mixed-mode chromatography on removing a weakly-bound byproduct: A case study of bispecific antibody purification

Authors: Shengwei Zhang, Ting Zhang, Yifeng Li, Yan Wan

Journal: Protein Expr Purif

PubMed ID: 34303809

Doi: 10.1016/j.pep.2021.105948

Products & Services: Proteins, Expression, Isolation and Analysis

A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model

Authors: Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon, Francois Chesnais, Jonathan De Smedt, Tine Tricot, Teresa Izuel Idoype, Marco Canella, Pierre Tilliole, Jolan De Boeck, Manmohan Bajaj, Adrian Ranga, Francesca Maria Bosisio, Tania Roskams, Leo A van Grunsven, Catherine M Verfaillie

Journal: Biomaterials

PubMed ID: 34304139

Doi: 10.1016/j.biomaterials.2021.121006

Products & Services: Proteins, Expression, Isolation and Analysis

A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease

Authors: Zhou Sha, Monica M Montano, Kristy Rochon, Jason A Mears, Daniel Deredge, Patrick Wintrode, Luke Szweda, Natalie Mikita, Irene Lee

Journal: Arch Biochem Biophys

PubMed ID: 34228963

Doi: 10.1016/j.abb.2021.108983

Products & Services: Proteins, Expression, Isolation and Analysis

MIR156-Targeted SPL9 Is Phosphorylated by SnRK2s and Interacts With ABI5 to Enhance ABA Responses in

Authors: Huixue Dong, Suli Yan, Yexing Jing, Ruizhen Yang, Yunwei Zhang, Yun Zhou, Yingfang Zhu, Jiaqiang Sun

Journal: Front Plant Sci

PubMed ID: 34367226

Doi: 10.3389/fpls.2021.708573

Products & Services: Proteins, Expression, Isolation and Analysis

Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level

Authors: Matthew K H Wong, Mulan He, Kong Hung Sze, Tao Huang, Wendy K W Ko, Zhao-Xiang Bian, Anderson O L Wong

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34276561

Doi: 10.3389/fendo.2021.681646

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Elimination of SARS-CoV-2 along wastewater and sludge treatment processes

Authors: Albert Serra-Compte, Susana González, Marina Arnaldos, Sabrina Berlendis, Sophie Courtois, Jean Francois Loret, Olivier Schlosser, Adela M Yáñez, Elena Soria-Soria, Mariana Fittipaldi, Gemma Saucedo, Anna Pinar-Méndez, Miquel Paraira, Belén Galofré, Juan M Lema, Sabela Balboa, Miguel Mauricio-Iglesias, Albert Bosch, Rosa M Pintó, Isabelle Bertrand, Christophe Gantzer, Carlos Montero, Xavier Litrico

Journal: Water Res

PubMed ID: 34330027

Doi: 10.1016/j.watres.2021.117435

Products & Services: Plasmid DNA Preparation

Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery

Authors: Choon Kim, Kiran V Mahasenan, Atul Bhardwaj, Olaf Wiest, Mayland Chang, Shahriar Mobashery

Journal: ACS Omega

PubMed ID: 34337272

Doi: 10.1021/acsomega.1c02984

Products & Services: Plasmid DNA Preparation

Structure of human Ca22 channel blocked by the painkiller ziconotide

Authors: Shuai Gao, Xia Yao, Nieng Yan

Journal: Nature

PubMed ID: 34234349

Doi: 10.1038/s41586-021-03699-6

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A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates importance of Smn for maintenance of mature motor neurons

Authors: Shermaine Huiping Tay, Erna Nur Ellieyana, Yao Le, Menachem Viktor Sarusie, Clemens Grimm, Jürgen Ohmer, Ajay Mathuru, Utz Fischer, Christoph Winkler

Journal: Hum Mol Genet

PubMed ID: 34302176

Doi: 10.1093/hmg/ddab212

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Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity

Authors: Nichole Orench-Rivera, Meta J Kuehn

Journal: Front Microbiol

PubMed ID: 34276573

Doi: 10.3389/fmicb.2021.561863

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Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid

Authors: Francesca Sara Colizzi, Katharina Beer, Paolo Cuti, Peter Deppisch, David Martínez Torres, Taishi Yoshii, Charlotte Helfrich-Förster

Journal: Front Physiol

PubMed ID: 34366893

Doi: 10.3389/fphys.2021.705048

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An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity

Authors: Anne-Catherine Fluckiger, Barthelemy Ontsouka, Jasminka Bozic, Abebaw Diress, Tanvir Ahmed, Tamara Berthoud, Anh Tran, Diane Duque, Mingmin Liao, Michael McCluskie, Francisco Diaz-Mitoma, David E Anderson, Catalina Soare

Journal: Vaccine

PubMed ID: 34304928

Doi: 10.1016/j.vaccine.2021.07.034

Products & Services: PCR Cloning and Subcloning

ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta

Authors: Anis Meschichi, Mathieu Ingouff, Claire Picart, Marie Mirouze, Sophie Desset, Franck Gallardo, Kerstin Bystricky, Nathalie Picault, Stefanie Rosa and Frédéric Pontvianne

Journal: Frontier in Plate Science

PubMed ID: 34295343

Doi: 10.3389/fpls.2021.677849

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ANXA10 Promotes Melanoma Metastasis by Suppressing the Ubiquitination of PKD1 Mediated by E3 Ligase TRIM41

Authors: Xuerui Zhang, Zhaoqing Hu, Xinran Wang, Lin Li, Banghui Zhu, Xiaolei Lin, Jing Zhang, Zichun Hua

Journal: Cancer Letters

Doi: doi.org/10.1016/j.canlet.2021.07.033

Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition

Authors: Yun-Yun Fan, Yu-Wei Zhong, Jing Zhao, Yao Chi, Sophie Bouvaine, Shu-Sheng Liu, Susan E Seal, Xiao-Wei Wang

Journal: Cells.

PubMed ID: 34359870

Doi: 10.3390/cells10071700

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First trimester screening with biochemical markers and ultrasound in relation to non-invasive prenatal testing (NIPT)

Authors:

Journal: J Perinat Med

PubMed ID: 34225389

Doi: 10.1515/jpm-2021-0243

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miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells

Authors: Arivarasu N Anbazhagan, Shubha Priyamvada, Anoop Kumar, Dulari Jayawardena, Alip Borthakur, Seema Saksena, Ravinder K Gill, Waddah A Alrefai, Pradeep K Dudeja

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34231393

Doi: 10.1152/ajpgi.00148.2021

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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

Authors: Sebastian M Dieter, Christine Siegl, Paula L Codó, Mario Huerta, Anna L Ostermann-Parucha, Erik Schulz, Martina K Zowada, Sylvia Martin, Karin Laaber, Ali Nowrouzi, Mona Blatter, Sina Kreth, Frank Westermann, Axel Benner, Ulrike Uhrig, Kerstin Putzker, Joe Lewis, Andrea Haegebarth, Dominik Mumberg, Simon J Holton, Joerg Weiske, Lena-Marit Toepper, Ulrike Scheib, Gerhard Siemeister, Claudia R Ball, Bernhard Kuster, Gabriele Stoehr, Hannes Hahne, Sarah Johannes, Martin Lange, Friederike Herbst, Hanno Glimm

Journal: Cell Rep

PubMed ID: 34289372

Doi: 10.1016/j.celrep.2021.109394

Products & Services: Mammalian Expression

Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum

Authors: Larry C Cheng, Dinghai Zheng, Qiang Zhang, Aysegul Guvenek, Hong Cheng, Bin Tian

Journal: Cell Rep

PubMed ID: 34289366

Doi: 10.1016/j.celrep.2021.109407

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Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

Authors: Li Wang, Xin-Feng Jiao, Cheng Wu, Xiao-Qing Li, Hui-Xian Sun, Xi-Yu Shen, Kang-Zhen Zhang, Can Zhao, Li Liu, Man Wang, Yun-Ling Bu, Jia-Wen Li, Fan Xu, Chen-Lu Chang,Xiang Lu,corresponding author and Wei Gaocorresponding author

Journal: Journal List

PubMed ID: 34537816

Doi: 10.1038/s41420-021-00648-0

Products & Services: Proteins, Expression, Isolation and Analysis

Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus

Authors: Mengxin Zhou, Yutong Han, Mengxia Li, Gang Ye, Guiqing Peng

Journal: Virol Sin

PubMed ID: 34228261

Doi: 10.1007/s12250-021-00415-6

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Functional Characterization of Ecdysis Triggering Hormone Receptors (AgETHR-A and AgETHR-B) in the African Malaria Mosquito,

Authors: Vikas Jindal, Yoonseong Park, Donghun Kim

Journal: Front Physiol

PubMed ID: 34295267

Doi: 10.3389/fphys.2021.702979

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Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays

Authors: Anton M Sholukh, Andrew Fiore-Gartland, Emily S Ford, Maurine D Miner, Yixuan J Hou, Longping V Tse, Hannah Kaiser, Haiying Zhu, Joyce Lu, Bhanupriya Madarampalli, Arnold Park, Florian A Lempp, Russell St Germain, Emily L Bossard, Jia Jin Kee, Kurt Diem, Andrew B Stuart, Peter B Rupert, Chance Brock, Matthew Buerger, Margaret K Doll, April Kaur Randhawa, Leonidas Stamatatos, Roland K Strong, Colleen McLaughlin, Meei-Li Huang, Keith R Jerome, Ralph S Baric, David Montefiori, Lawrence Corey

Journal: J Clin Microbiol

PubMed ID: 34288726

Doi: 10.1128/JCM.00527-21

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Simultaneous Removal of the Freshwater Bloom-Forming Cyanobacterium and Cyanotoxin Microcystins via Combined Use of Algicidal Bacterial Filtrate and the Microcystin-Degrading Enzymatic Agent, MlrA

Authors: Suqin Wang, Siyu Yang, Jun Zuo, Chenlin Hu, Lirong Song, Nanqin Gan, Peng Chen

Journal: Microorganisms

PubMed ID: 34442673

Doi: 10.3390/microorganisms9081594

Products & Services: Proteins, Expression, Isolation and Analysis

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

Authors: Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Wong

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34276562

Doi: 10.3389/fendo.2021.681647

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Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway

Authors: Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan, Jing Yu

Journal: J Inflamm Res

PubMed ID: 34285539

Doi: 10.2147/JIR.S306456

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GhKWL1 Upregulates but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of

Authors: Yang Chen, Mi Zhang, Lei Wang, Xiaohan Yu, Xianbi Li, Dan Jin, Jianyan Zeng, Hui Ren, Fanlong Wang, Shuiqing Song, Xingying Yan, Juan Zhao, Yan Pei

Journal: Int J Mol Sci

PubMed ID: 34298948

Doi: 10.3390/ijms22147328

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The DUB family in Populus: identification, characterization, evolution and expression patterns

Authors: Wenqing Zheng, Liang Du

Journal: BMC Genomics

PubMed ID: 34266381

Doi: 10.1186/s12864-021-07844-3

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The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase

Authors: Ankoor Patel, Jessica A M McBride, Brian L Mark

Journal: J Biol Chem

PubMed ID: 34265303

Doi: 10.1016/j.jbc.2021.100957

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Comprehensive Characterization of Universal Stress Proteins in Rice ( L) With Insight Into Their Stress-Specific Transcriptional Modulation

Authors: Shatil Arabia, Asif Ahmed Sami, Saima Akhter, Rakha Hari Sarker, Tahmina Islam

Journal: Front Plant Sci

PubMed ID: 34394169

Doi: 10.3389/fpls.2021.712607

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WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation

Authors: Yvonne Xinyi Lim, Hexian Lin, Tinghine Chu, Yoon Pin Lim

Journal: Mol Oncol

PubMed ID: 34197030

Doi: 10.1002/1878-0261.13048

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Development of a Platform for Noncovalent Coupling of Full Antigens to Tobacco Etch Virus-Like Particles by Means of Coiled-Coil Oligomerization Motifs

Authors: Lorena Zapata-Cuellar, Jorge Gaona-Bernal, Carlos Alberto Manuel-Cabrera, Moisés Martínez-Velázquez, Carla Sánchez-Hernández, Darwin Elizondo-Quiroga, Tanya Amanda Camacho-Villegas, Abel Gutiérrez-Ortega

Journal: Molecules

PubMed ID: 34361589

Doi: 10.3390/molecules26154436

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Melioidosis Patient Survival Correlates With Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM

Authors: Sineenart Sengyee, Atchara Yarasai, Rachan Janon, Chumpol Morakot, Orawan Ottiwet, Lindsey K Schmidt, T Eoin West, Mary N Burtnick, Narisara Chantratita, Paul J Brett

Journal: Front Immunol

PubMed ID: 34394091

Doi: 10.3389/fimmu.2021.698303

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CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus

Authors: Woojong Lee, Brock Kingstad-Bakke, Ross M Kedl, Yoshihiro Kawaoka, M Suresh

Journal: J Virol

PubMed ID: 33952647

Doi: 10.1128/JVI.00530-21

Products & Services: Mammalian Expression

In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish () Treated with the Novel Anti-Inflammatory Peptide P

Authors: Geonildo R Disner, Maria A P Falcão, Carla Lima, Monica Lopes-Ferreira

Journal: Int J Mol Sci

PubMed ID: 34281170

Doi: 10.3390/ijms22137117

Products & Services: Proteins, Expression, Isolation and Analysis

Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins

Authors: Dorota Satala, Grzegorz Satala, Marcin Zawrotniak, Andrzej Kozik

Journal: BMC Microbiol

PubMed ID: 34210257

Doi: 10.1186/s12866-021-02235-w

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African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells

Authors: Sabal Chaulagain, Gustavo A Delhon, Sushil Khatiwada, Daniel L Rock

Journal: Viruses

PubMed ID: 34452346

Doi: 10.3390/v13081480

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Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

Authors: Jun Zhang, Jennifer F Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A Rey, William J Snell

Journal: Nat Commun

PubMed ID: 34282138

Doi: 10.1038/s41467-021-24613-8

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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

Authors: Benjamin J Eduful, Sean N O'Byrne, Louisa Temme, Christopher R M Asquith, Yi Liang, Alfredo Picado, Joseph R Pilotte, Mohammad Anwar Hossain, Carrow I Wells, William J Zuercher, Carolina M C Catta-Preta, Priscila Zonzini Ramos, André de S Santiago, Rafael M Couñago, Christopher G Langendorf, Kévin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M Willson, Daniel E Frigo, John W Scott, David H Drewry

Journal: J Med Chem

PubMed ID: 34264658

Doi: 10.1021/acs.jmedchem.0c02274

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Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus

Authors: Zahra Najarzadeh, Masihuz Zaman, Vita Sereikaite, Kristian Strømgaard, Maria Andreasen, Daniel E Otzen

Journal: J Biol Chem

PubMed ID: 34270957

Doi: 10.1016/j.jbc.2021.100953

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Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes

Authors: Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth

Journal: Elife

PubMed ID: 34259632

Doi: 10.7554/eLife.67268

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spp Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Authors: Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong

Journal: Front Microbiol

PubMed ID: 34394047

Doi: 10.3389/fmicb.2021.702881

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A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

Authors: Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa

Journal: Front Cell Dev Biol

PubMed ID: 34307350

Doi: 10.3389/fcell.2021.665673

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Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell

Authors: Suleman S Hussain, Rahul Majumdar, Grace M Moore, Himanshi Narang, Erika S Buechelmaier, Maximilian J Bazil, Pavithran T Ravindran, Jonathan E Leeman, Yi Li, Manisha Jalan, Kyrie S Anderson, Andrea Farina, Rekha Soni, Neeman Mohibullah, Edin Hamzic, Xiaoqing Rong-Mullins, Christopher Sifuentes, Rama R Damerla, Agnes Viale, Simon N Powell, Daniel S Higginson

Journal: Nucleic Acids Res

PubMed ID: 33877327

Doi: 10.1093/nar/gkab262

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P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice

Authors: Laura Schnöder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu

Journal: FASEB J

PubMed ID: 34118085

Doi: 10.1096/fj.202100017R

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Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

Authors: Elizabeth K Wiese, Sadae Hitosugi, Sharon T Loa, Annapoorna Sreedhar, Lindsey G Andres-Beck, Kiran Kurmi, Yuan-Ping Pang, Larry M Karnitz, Wilson I Gonsalves, Taro Hitosugi

Journal: Nat Metab

PubMed ID: 34226744

Doi: 10.1038/s42255-021-00424-5

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Current diagnostic approaches to detect two important betacoronaviruses: Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Authors: Zhi Xiong Chong, Winnie Pui Pui Liew, Hui Kian Ong, Chean Yeah Yong, Chong Seng Shit, Wan Yong Ho, Stephanie Y L Ng, Swee Keong Yeap

Journal: Pathol Res Pract

PubMed ID: 34333398

Doi: 10.1016/j.prp.2021.153565

Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Authors: Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gassen

Journal: Nat Commun

PubMed ID: 34330919

Doi: 10.1038/s41467-021-24810-5

Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface

Authors: Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Štefulj

Journal: Int J Mol Sci

PubMed ID: 34360573

Doi: 10.3390/ijms22157807

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Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions

Authors: Amit Kumar, ProfilePrateek Kumar, Kumar Udit Saumya, ProfileRajanish Giri

Journal: biorxiv

Doi: doi.org/10.1101/2021.07.06.451329

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Genome-wide identification of heat shock transcription factors and potential role in regulation of antioxidant response under hot water and glycine betaine treatments in cold-stored peaches

Authors: Li Wang, Yuanyuan Hou, Yi Wang, Shunqing Hu, Yonghua Zheng, Peng Jin

Journal: J Sci Food Agric

PubMed ID: 34146341

Doi: 10.1002/jsfa.11392

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The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

Authors: Yisheng He, Jiang Ma, Xiaoyu Fan, Liang Ding, Xinxin Ding, Qing-Yu Zhang, Ge Lin

Journal: Acta Pharm Sin B

PubMed ID: 35024309

Doi: 10.1016/j.apsb.2021.07.013

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Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease

Authors: Christina F de Veij Mestdagh, Jaap A Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S M Miedema, Maaike Goris, Rolinka J van der Loo, Guido Krenning, Ka Wan Li, Huibert D Mansvelder, August B Smit, Robert H Henning, Ronald E van Kesteren

Journal: Sci Rep

PubMed ID: 34326412

Doi: 10.1038/s41598-021-94992-x

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Human cell transformation by combined lineage conversion and oncogene expression

Authors: Biswajyoti Sahu, Päivi Pihlajamaa, Kaiyang Zhang, Kimmo Palin, Saija Ahonen, Alejandra Cervera, Ari Ristimäki, Lauri A Aaltonen, Sampsa Hautaniemi, Jussi Taipale

Journal: Oncogene

PubMed ID: 34302118

Doi: 10.1038/s41388-021-01940-0

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Tumor-promoting function of PIMREG in glioma by activating the β-catenin pathway

Authors: Dekang Wang, Aili Hu, Hao Peng, Dongbo Li, Li Zhang

Journal: 3 Biotech

PubMed ID: 34458056

Doi: 10.1007/s13205-021-02922-5

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A 5'-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

Authors: Litao Han, Hejing Lai, Yichen Yang, Jiaqian Hu, Zhe Li, Ben Ma, Weibo Xu, Wanlin Liu, Wenjun Wei, Duanshu Li, Yu Wang, Qiwei Zhai, Qinghai Ji, Tian Liao

Journal: J Exp Clin Cancer Res

PubMed ID: 34225773

Doi: 10.1186/s13046-021-02024-3

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PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

Authors: Yihui Ma, Peiyi Xia, Zhengyang Wang, Jingjing Xu, Lan Zhang, Yanan Jiang

Journal: Neoplasia

PubMed ID: 34325342

Doi: 10.1016/j.neo.2021.07.004

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Chemical Synthesis of the Sec-To-Cys Homologue of Human Selenoprotein F and Elucidation of Its Disulfide-pairing Mode

Authors: Peisi Liao, Chunmao He

Journal: Front Chem

PubMed ID: 34395389

Doi: 10.3389/fchem.2021.735149

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Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity

Authors: Ling He, Yuting Yang, Juan Chen, Pengtao Zou, Juxiang Li

Journal: Mol Med Rep

PubMed ID: 34296293

Doi: 10.3892/mmr.2021.12307

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Functional Expression of a Mo-Cu-Dependent Carbon Monoxide Dehydrogenase (CODH) and Its Use as a Dissolved CO Bio-microsensor

Authors: Stacy Simai Reginald, Michael Etzerodt, Deby Fapyane, In Seop Chang

Journal: ACS Sens

PubMed ID: 34253013

Doi: 10.1021/acssensors.1c01243

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Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Authors: Qian-Qian Zhu, Xi-Bin Pu, Tian-Chi Chen, Chen-Yang Qiu, Zi-Heng Wu, Lu Tian, Yang-Yan He, Xiao-Hui Wang, Tao Shang, Xun Wang, Yi-Lang Xiang, Dong-Lin Li, Hong-Kun Zhang

Journal: Cell Cycle

PubMed ID: 34223793

Doi: 10.1080/15384101.2021.1918877

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The reductive carboxylation activity of heterotetrameric pyruvate synthases from hyperthermophilic archaea

Authors: Lu Xiao, Guoxia Liu, Fuyu Gong, Zhen Cai, Yin Li

Journal: Biochem Biophys Res Commun

PubMed ID: 34364295

Doi: 10.1016/j.bbrc.2021.07.091

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Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated

Authors: Esther Broset, Juan Calvet Seral, Carmen Arnal, Santiago Uranga, Alex I Kanno, Luciana C C Leite, Carlos Martín, Jesús Gonzalo-Asensio

Journal: Comput Struct Biotechnol J

PubMed ID: 34429847

Doi: 10.1016/j.csbj.2021.07.035

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Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution

Authors: Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K-S Wong, John L Spudich

Journal: MBio

PubMed ID: 34281394

Doi: 10.1128/mBio.01656-21

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CD8 T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

Authors: Vamsee Mallajosyula, Conner Ganjavi, Saborni Chakraborty, Alana M McSween, Ana Jimena Pavlovitch-Bedzyk, Julie Wilhelmy, Allison Nau, Monali Manohar, Kari C Nadeau, Mark M Davis

Journal: Sci Immunol

PubMed ID: 34210785

Doi: 10.1126/sciimmunol.abg5669

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SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Authors: Tyler N Starr, Nadine Czudnochowski, Zhuoming Liu, Fabrizia Zatta, Young-Jun Park, Amin Addetia, Dora Pinto, Martina Beltramello, Patrick Hernandez, Allison J Greaney, Roberta Marzi, William G Glass, Ivy Zhang, Adam S Dingens, John E Bowen, M Alejandra Tortorici, Alexandra C Walls, Jason A Wojcechowskyj, Anna De Marco, Laura E Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, Josh R Dillen, Heather Tucker, Jessica Bassi, Chiara Silacci-Fregni, Michael P Housley, Julia di Iulio, Gloria Lombardo, Maria Agostini, Nicole Sprugasci, Katja Culap, Stefano Jaconi, Marcel Meury, Exequiel Dellota, Rana Abdelnabi, Shi-Yan Caroline Foo, Elisabetta Cameroni, Spencer Stumpf, Tristan I Croll, Jay C Nix, Colin Havenar-Daughton, Luca Piccoli, Fabio Benigni, Johan Neyts, Amalio Telenti, Florian A Lempp, Matteo S Pizzuto, John D Chodera, Christy M Hebner, Herbert W Virgin, Sean P J Whelan, David Veesler, Davide Corti, Jesse D Bloom, Gyorgy Snell

Journal: Nature

PubMed ID: 34261126

Doi: 10.1038/s41586-021-03807-6

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Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application

Authors: Filip Koper, Tomasz Swiergosz, Anna Żaba, Agata Flis, Martina Trávníčková, Lucie Bačáková, Elżbieta Pamuła, Dariusz Bogdał, Wiktor P Kasprzyk

Journal: J Mater Chem B

PubMed ID: 34323912

Doi: 10.1039/d1tb01078f

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Quantitative probing of glycosylated queuosine modifications in tRNA

Authors: Wen Zhang, Tao Pan

Journal: Methods Enzymol

PubMed ID: 34517960

Doi: 10.1016/bs.mie.2021.06.003

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Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1

Authors: Nikole L Warner, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 34358143

Doi: 10.3390/vaccines9070726

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CEACAM1 Activation by CbpF-Expressing

Authors: Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J Slade, Ofer Mandelboim, Gilad Bachrach

Journal: Front Cell Infect Microbiol

PubMed ID: 34395310

Doi: 10.3389/fcimb.2021.699015

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Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types

Authors: Jamil N Kanji, Ashley Bailey, Jayne Fenton, L Robbin Lindsay, Antonia Dibernardo, Nikki Pl Toledo, Brooks Waitt, Nadine Lecocq, Carla Osiowy, Elizabeth Giles, Jacqueline Day, William Stokes, Clayton MacDonald, LeeAnn Turnbull, Carmen Charlton

Journal: J Clin Virol

PubMed ID: 34364133

Doi: 10.1016/j.jcv.2021.104933

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Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species

Authors: Anberitha T Matthews, Hitesh Soni, Katherine E Robinson-Freeman, Theresa A John, Randal K Buddington, Adebowale Adebiyi

Journal: Int J Mol Sci

PubMed ID: 34299212

Doi: 10.3390/ijms22147589

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Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus

Authors: Yong Feng, Ping Wu, Chao Liu, Liwei Peng, Tao Wang, Chao Wang, Qian Tan, Bixuan Li, Yajuan Ou, Hui Zhu, Songli Yuan, Renliang Huang, Gary Stacey, Zhongming Zhang, Yangrong Cao

Journal: Mol Plant

PubMed ID: 34314895

Doi: 10.1016/j.molp.2021.07.016

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Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

Authors: Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 34266885

Doi: 10.1136/jitc-2021-002882

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EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

Authors: Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V Catapano, Giuseppina M Carbone

Journal: Nat Commun

PubMed ID: 34230470

Doi: 10.1038/s41467-021-24380-6

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A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Authors: Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia

Journal: Sci Transl Med

PubMed ID: 34285130

Doi: 10.1126/scitranslmed.abg1143

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Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

Authors: Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang

Journal: J Immunother Cancer

PubMed ID: 34230110

Doi: 10.1136/jitc-2021-002454

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Alfalfa (Medicago sativa L) MsCML46 gene encoding calmodulin-like protein confers tolerance to abiotic stress in tobacco

Authors: Binghao Du, Naiyu Chen, Lili Song, Dan Wang, Hongsheng Cai, Lin Yao, Xiuting Li, Changhong Guo

Journal: Plant Cell Rep

PubMed ID: 34322731

Doi: 10.1007/s00299-021-02757-7

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A Titratable Cell Lysis-on-Demand System for Droplet-Compartmentalized Ultrahigh-Throughput Screening in Functional Metagenomics and Directed Evolution

Authors: Che Fai Alex Wong, Liisa van Vliet, Swapnil Vilas Bhujbal, Chengzhi Guo, Marit Sletmoen, Bjørn Torger Stokke, Florian Hollfelder, Rahmi Lale

Journal: ACS Synth Biol

PubMed ID: 34260196

Doi: 10.1021/acssynbio.1c00084

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Authors: Robert L Summers, Charisse Flerida A Pasaje, Joao P Pisco, Josefine Striepen, Madeline R Luth, Krittikorn Kumpornsin, Emma F Carpenter, Justin T Munro, De Lin, Andrew Plater, Avinash S Punekar, Andrew M Shepherd, Sharon M Shepherd, Manu Vanaerschot, James M Murithi, Kelly Rubiano, Aslı Akidil, Sabine Ottilie, Nimisha Mittal, A Hazel Dilmore, Madalyn Won, Rebecca E K Mandt, Kerry McGowen, Edward Owen, Chris Walpole, Manuel Llinás, Marcus C S Lee, Elizabeth A Winzeler, David A Fidock, Ian H Gilbert, Dyann F Wirth, Jacquin C Niles, Beatriz Baragaña, Amanda K Lukens

Journal: Cell Chem Biol

PubMed ID: 34348113

Doi: 10.1016/j.chembiol.2021.07.010

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Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism

Authors: Karen V Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 34354688

Doi: 10.3389/fmicb.2021.691731

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Mitofusion is required for MOTS-c induced GLUT4 translocation

Authors: Khushwant S Bhullar, Nan Shang, Evan Kerek, Kaiyu Wu, Jianping Wu

Journal: Sci Rep

PubMed ID: 34253808

Doi: 10.1038/s41598-021-93735-2

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