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A highly efficient identification of mutants generated by CRISPR/Cas9 using the non‑functional DsRed assisted selection in Aspergillus oryzae

Authors: Yuzhen Li, Huanxin Zhang, Junxia Fan, Ziming Chen, Tianming Chen, Bin Zeng, Zhe Zhang

Journal: World J Microbiol Biotechnol

PubMed ID: 34240255

Doi: 10.1007/s11274-021-03100-8

Products & Services: Gene Synthesis

Rapid and cost-effective process based on insect larvae for scale-up production of SARS-COV-2 spike protein for serological COVID-19 testing

Authors: Ignacio Smith, Gregorio Juan Mc Callum, Adriana Victoria Sabljic, Juan Ignacio Marfia, Silvina Sonia Bombicino, Aldana Trabucchi, Ruben Francisco Iacono, Joaquín Manuel Birenbaum, Susana Claudia Vazquez, Juan Mauricio Minoia, Osvaldo Cascone, María Gabriela López, Oscar Taboga, Alexandra Marisa Targovnik, Federico Javier Wolman, Matías Fingermann, Leonardo Gabriel Alonso, Silvina Noemí Valdez, María Victoria Miranda

Journal: Biotechnol Bioeng

PubMed ID: 34264519

Doi: 10.1002/bit.27889

Products & Services: DNA Sequencing

Absence of SARS-CoV-2 Antibodies in Natural Environment Exposure in Sheep in Close Contact with Humans

Authors: Sergio Villanueva-Saz, Jacobo Giner, Antonio Fernández, Delia Lacasta, Aurora Ortín, Juan José Ramos, Luis Miguel Ferrer, Marta Ruiz de Arcaute, Ana Pilar Tobajas, María Dolores Pérez, Maite Verde, Diana Marteles, Ramón Hurtado-Guerrero, Julián Pardo, Llipsy Santiago, Andrés Manuel González-Ramírez, Javier Macías-León, Ana García-García, Víctor Taleb, Erandi Lira-Navarrete, José Ramón Paño-Pardo, Héctor Ruíz

Journal: Animals (Basel)

PubMed ID: 34359111

Doi: 10.3390/ani11071984

Products & Services: DNA Sequencing

The Knockdown of Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon Downregulation

Authors: Lidong Wang, Ying Zhang, Jiapeng Yang, Lei Liu, Baiyu Yao, Zhong Tian, Jingni He

Journal: DNA Cell Biol

PubMed ID: 34283663

Doi: 10.1089/dna.2021.0216

Products & Services: DNA Sequencing

m(6)A Modification of lncRNA NEAT1 Regulates Chronic Myelocytic Leukemia Progression miR-766-5p/CDKN1A Axis

Authors: Fang-Yi Yao, Cui Zhao, Fang-Min Zhong, Ting-Yu Qin, Fang Wen, Mei-Yong Li, Jing Liu, Bo Huang, Xiao-Zhong Wang

Journal: Front Oncol

PubMed ID: 34354942

Doi: 10.3389/fonc.2021.679634

Products & Services: DNA Sequencing

Structure of respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Authors: Piotr Kolata, Rouslan G Efremov

Journal: Elife

PubMed ID: 34308841

Doi: 10.7554/eLife.68710

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Depolymerization of biorefinery lignin by improved laccases of the white-rot fungus Obba rivulosa

Authors: Janne Wallenius, Jussi Kontro, Christina Lyra, Jaana Kuuskeri, Xing Wan, Mika A Kähkönen, Irshad Baig, Paul C J Kamer, Jussi Sipilä, Miia R Mäkelä, Paula Nousiainen, Kristiina Hildén

Journal: Microb Biotechnol

PubMed ID: 34310858

Doi: 10.1111/1751-7915.13896

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Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN

Authors: Wenying Gao, Zhenglong Jin, Yanxia Zheng, Youjia Xu

Journal: Mol Med Rep

PubMed ID: 34278468

Doi: 10.3892/mmr.2021.12291

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Multiple neuronal networks coordinate mechanosensory behavior

Authors: Krishna N Badhiwala, Abby S Primack, Celina E Juliano, Jacob T Robinson

Journal: Elife

PubMed ID: 34328079

Doi: 10.7554/eLife.64108

Products & Services: Codon Optimization

Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture

Authors: Julia Nörpel, Simone Cavadini, Andreas D Schenk, Alexandra Graff-Meyer, Daniel Hess, Jan Seebacher, Jeffrey A Chao, Varun Bhaskar

Journal: PLoS Biol

PubMed ID: 34297726

Doi: 10.1371/journal.pbio.3001344

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Observing reorientation dynamics with Time-Resolved fluorescence and molecular dynamics in varying periodic boundary conditions

Authors: Gouri S Jas, Ed W Childs, C Russell Middaugh, Krzysztof Kuczera

Journal: J Biomol Struct Dyn

PubMed ID: 34308794

Doi: 10.1080/07391102.2021.1947894

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Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

Authors: Yongbing Pan, Jianhui Du, Jia Liu, Hai Wu, Fang Gui, Nan Zhang, Xiaojie Deng, Gang Song, Yufeng Li, Jia Lu, Xiaoli Wu, ShanShan Zhan, Zhaofei Jing, Jiong Wang, Yimin Yang, Jianbang Liu, Ying Chen, Qin Chen, Huanyu Zhang, Hengrui Hu, Kai Duan, Manli Wang, Qisheng Wang, Xiaoming Yang

Journal: Cell Discov

PubMed ID: 34315862

Doi: 10.1038/s41421-021-00295-w

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Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Authors: Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M T Burgering

Journal: Cell Rep

PubMed ID: 34320339

Doi: 10.1016/j.celrep.2021.109446

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Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing

Authors: Shanshan Cheng, Yuqian Shen, Zi Chao Zhang, Junhai Han

Journal: STAR Protoc

PubMed ID: 34337444

Doi: 10.1016/j.xpro.2021.100679

Products & Services: Peptide Synthesis

A novel larval diet interacts with nutritional stress to modify juvenile behaviors and glucocorticoid responses

Authors: Cristina C Ledón-Rettig, Sarah R Lagon

Journal: Ecol Evol

PubMed ID: 34429887

Doi: 10.1002/ece3.7860

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk

Authors: Chathura D Suraweera , Mark G Hinds , Marc Kvansakul

Journal: Viruses

PubMed ID: 34372579

Doi: 10.3390/v13071374

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Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway

Authors: Jian Cheng , Xiao Wang, Xiaonan Liu , Xiaoxi Zhu , Zihe Li , Huanyu Chu , Qian Wang , QianQian Lou , Bijun Cai , Yiqun Yang , Xiaoyun Lu , Kai Peng , Dingyu Liu , Yuwan Liu , Lina Lu , Huan Liu , Ting Yang , Qijin Ge , Chengcheng Shi , Guichun Liu , Zhiwei Dong , Xun Xu , Wen Wang , Huifeng Jiang , Yanhe Ma

Journal: Mol Plant

PubMed ID: 33951484

Doi: 10.1016/j.molp.2021.04.015

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Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)

Authors: Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko, Liliana Torcoroma García

Journal: BMC Complement Med Ther

PubMed ID: 34215249

Doi: 10.1186/s12906-021-03347-6

Products & Services: PCR Cloning and Subcloning

Evidence for a chromosome origin unwinding system broadly conserved in bacteria

Authors: Simone Pelliciari, Mei-Jing Dong, Feng Gao, Heath Murray

Journal: Nucleic Acids Res

PubMed ID: 34197592

Doi: 10.1093/nar/gkab560

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Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine

Authors: Kelly L Hawley, Jairo M Montezuma-Rusca, Kristina N Delgado, Navreeta Singh, Vladimir N Uversky, Melissa J Caimano, Justin D Radolf, Amit Luthra

Journal: J Bacteriol

PubMed ID: 33972353

Doi: 10.1128/JB.00082-21

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Genetic Code Expansion: A Brief History and Perspective

Authors: Mia A Shandell, Zhongping Tan, Virginia W Cornish

Journal: Biochemistry

PubMed ID: 34196546

Doi: 10.1021/acs.biochem.1c00286

Products & Services: Molecular Biology Tools

Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Authors: Jun-Ichi Kashiwakura, Nao Koizumi, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Shoya Kawahara, Yukie Yamauchi, Yuichi Kitai, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda

Journal: Biochem Biophys Res Commun

PubMed ID: 34358967

Doi: 10.1016/j.bbrc.2021.07.098

Products & Services: Proteins, Expression, Isolation and Analysis

Optimizing the Expression and Solubilization of an E coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice

Authors: Nahid Mehri, Abbas Jamshidizad, Zahra Ghanei, Ali-Asghar Karkhane, Mehdi Shamsara

Journal: Mol Biotechnol

PubMed ID: 34272681

Doi: 10.1007/s12033-021-00369-w

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Characterization of gH/gL/pUL128-131 pentameric complex, gH/gL/gO trimeric complex, gB and gM/gN glycoproteins in a human cytomegalovirus using automated capillary western blots

Authors: Richard R Rustandi, John W Loughney, Liang Shang, Shiyi Wang, Cindy J Pauley, Sianny Christanti, Adam Kristopeit, Timothy D Culp

Journal: Vaccine

PubMed ID: 34229890

Doi: 10.1016/j.vaccine.2021.06.033

Products & Services: Mammalian Expression

Altered chromatin architecture and gene expression during polyploidization and domestication of soybean

Authors: Longfei Wang, Guanghong Jia, Xinyu Jiang, Shuai Cao, Z Jeffrey Chen, Qingxin Song

Journal: Plant Cell

PubMed ID: 33730165

Doi: 10.1093/plcell/koab081

Products & Services: Proteins, Expression, Isolation and Analysis

The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid

Authors: Simona Dedoni, Luisa Marras, Maria C Olianas, Angela Ingianni, Pierluigi Onali

Journal: Int J Mol Sci

PubMed ID: 34360553

Doi: 10.3390/ijms22157790

Products & Services: Mammalian Expression

Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

Authors: Yen-Chin Liu, Bobo Wing-Yee Mok, Pui Wang, Rei-Lin Kuo, Honglin Chen, Shin-Ru Shih

Journal: MBio

PubMed ID: 34311580

Doi: 10.1128/mBio.00945-21

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Functional expression of the eukaryotic proton pump rhodopsin OmR2 in Escherichia coli and its photochemical characterization

Authors: Masuzu Kikuchi, Keiichi Kojima, Shin Nakao, Susumu Yoshizawa, Shiho Kawanishi, Atsushi Shibukawa, Takashi Kikukawa, Yuki Sudo

Journal: Sci Rep

PubMed ID: 34285294

Doi: 10.1038/s41598-021-94181-w

Products & Services: Mammalian Expression

CTP and coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

Authors: James A Taylor, Yeonee Seol, Jagat Budhathoki, Keir C Neuman, Kiyoshi Mizuuchi

Journal: Elife

PubMed ID: 34286695

Doi: 10.7554/eLife.65651

Products & Services: PCR Cloning and Subcloning

The circadian clock gates adult emergence by controlling the timecourse of metamorphosis

Authors: Brandon Mark, Liliana Bustos-González, Guadalupe Cascallares, Felipe Conejera, John Ewer

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34183412

Doi: 10.1073/pnas.2023249118

Products & Services: Proteins, Expression, Isolation and Analysis

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes

Authors: Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P M Labib

Journal: Biochem J

PubMed ID: 34195792

Doi: 10.1042/BCJ20210315

Products & Services: Mammalian Expression

KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D

Authors: Yonglan Wang, Kun Cao

Journal: J Immunol Res

PubMed ID: 34307695

Doi: 10.1155/2021/9965099

Structural and immunological characterization of an epitope within the PAN motif of ectodomain I in apical membrane antigen 1 for vaccine development

Authors: Amarin Rittipornlertrak, Boondarika Nambooppha, Anucha Muenthaisong, Veerasak Punyapornwithaya, Saruda Tiwananthagorn, Yang-Tsung Chung, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Nattawooti Sthitmatee

Journal: PeerJ

PubMed ID: 34316404

Doi: 10.7717/peerj.11765

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Identification of Three Clf-Sdr Subfamily Proteins in , and Comparative Genomics Analysis of a Locus Encoding CWA Proteins in Species

Authors: Zhewei Sun, Xueya Zhang, Danying Zhou, Kexin Zhou, Qiaoling Li, Hailong Lin, Wei Lu, Hongmao Liu, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Mei Zhu, Qiyu Bao, Hailin Zhang

Journal: Front Microbiol

PubMed ID: 34394031

Doi: 10.3389/fmicb.2021.691087

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The enhanced phosphorus use efficiency in phosphate-deficient and mycorrhiza-inoculated barley seedlings involves activation of different sets of PHT1 transporters in roots

Authors: Rajat Srivastava, Parul Sirohi, Harsh Chauhan, Rahul Kumar

Journal: Planta

PubMed ID: 34312721

Doi: 10.1007/s00425-021-03687-0

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Global Profiling of Phosphorylation Reveals the Barley Roots Response to Phosphorus Starvation and Resupply

Authors: Zengke Ma, Juncheng Wang, Chengdao Li, Panrong Ren, Lirong Yao, Baochun Li, Yaxiong Meng, Xiaole Ma, Erjing Si, Ke Yang, Xunwu Shang, Huajun Wang

Journal: Front Plant Sci

PubMed ID: 34335649

Doi: 10.3389/fpls.2021.676432

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AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment

Authors: Yue Yu, Shu-Ming Ye, De-Yun Liu, Li-Qi Yang

Journal: Exp Anim

PubMed ID: 34305077

Doi: 10.1538/expanim.21-0056

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CABE-RY: A PAM-flexible dual-mutation base editor for reliable modeling of multi-nucleotide variants

Authors: Wanyu Tao, Qing Liu, Shisheng Huang, Xin Wang, Shiyuan Qu, Junfan Guo, Danfeng Ou, Guanglei Li, Yu Zhang, Xiangmin Xu, Xingxu Huang

Journal: Mol Ther Nucleic Acids

PubMed ID: 34513298

Doi: 10.1016/j.omtn.2021.07.016

Products & Services: PCR Cloning and Subcloning

Characterization of the Role of the Neoxanthin Synthase Gene in Carotenoid Biosynthesis in Chinese Kale

Authors: Yue Jian, Chenlu Zhang, Yating Wang, Zhiqing Li, Jing Chen, Wenting Zhou, Wenli Huang, Min Jiang, Hao Zheng, Mengyao Li, Huiying Miao, Fen Zhang, Huanxiu Li, Qiaomei Wang, Bo Sun

Journal: Genes (Basel)

PubMed ID: 34440295

Doi: 10.3390/genes12081122

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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle

Authors: Yuanyuan Yu, Qingyun Zheng, Satchal K Erramilli, Man Pan, Seongjin Park, Yuan Xie, Jingxian Li, Jingyi Fei, Anthony A Kossiakoff, Lei Liu, Minglei Zhao

Journal: Nat Chem Biol

PubMed ID: 34239127

Doi: 10.1038/s41589-021-00823-5

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Muscone suppresses gastric cancer via regulation of miRNA-145

Authors: Feng Gao, Shihai Yan, Zheng Sun, Jia Wang

Journal: Food Sci Nutr

PubMed ID: 34531985

Doi: 10.1002/fsn3.2269

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The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach

Authors: Sergio Romero-Romero, Miguel Costas, Daniel-Adriano Silva Manzano, Sina Kordes, Erendira Rojas-Ortega, Cinthya Tapia, Yasel Guerra, Sooruban Shanmugaratnam, Adela Rodríguez-Romero, David Baker, Birte Höcker, D Alejandro Fernández-Velasco

Journal: J Mol Biol

PubMed ID: 34271011

Doi: 10.1016/j.jmb.2021.167153

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A Cas12a-based CRISPR interference system for multigene regulation in mycobacteria

Authors: Neil Fleck, Christoph Grundner

Journal: J Biol Chem

PubMed ID: 34298016

Doi: 10.1016/j.jbc.2021.100990

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Longitudinal evaluation of laboratory-based serological assays for SARS-CoV-2 antibody detection

Authors: K A Bond, E Williams, S Nicholson, S Lim, D Johnson, B Cox, M Putland, E Gardiner, E Tippett, M Graham, F Mordant, M Catton, S R Lewin, K Subbarao, B P Howden, D A Williamson

Journal: Pathology

PubMed ID: 34412859

Doi: 10.1016/j.pathol.2021.05.093

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Fast and reliable detection of SARS-CoV-2 antibodies based on surface plasmon resonance

Authors: Caroline Rodrigues Basso, Camila Dantas Malossi, Amanda Haisi, Valber de Albuquerque Pedrosa, Alexandre Naime Barbosa, Rejane Tommasini Grotto, João Pessoa Araujo Junior

Journal: Anal Methods

PubMed ID: 34231576

Doi: 10.1039/d1ay00737h

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Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes

Authors: Lucas F de Lima, André L Ferreira, Marcelo D T Torres, William R de Araujo, Cesar de la Fuente-Nunez

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34244421

Doi: 10.1073/pnas.2106724118

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Selective Inhibitors of the Inducible Nitric Oxide Synthase as Modulators of Cell Responses in LPS-Stimulated Human Monocytes

Authors: Marialucia Gallorini, Monica Rapino, Helmut Schweikl, Amelia Cataldi, Rosa Amoroso, Cristina Maccallini

Journal: Molecules

PubMed ID: 34361571

Doi: 10.3390/molecules26154419

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling

Authors: Hui-Hui Wang, Jia-Ni Ma, Xiao-Rong Zhan

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34290668

Doi: 10.3389/fendo.2021.670031

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CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells

Authors: Raviteja Inturi, Per Jemth

Journal: Virology

PubMed ID: 34280810

Doi: 10.1016/j.virol.2021.07.005

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Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection

Authors: José Javier Morales-Núñez, José Francisco Muñoz-Valle, Carlos Meza-López, Lin-Fa Wang, Andrea Carolina Machado Sulbarán, Paola Carolina Torres-Hernández, Martín Bedolla-Barajas, Brenda De la O-Gómez, Paulina Balcázar-Félix, Jorge Hernández-Bello

Journal: Vaccines (Basel)

PubMed ID: 34358158

Doi: 10.3390/vaccines9070742

Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts

Authors: Kittrawee Kritmetapak, Ravinder J Singh, Theodore A Craig, Jolaine M Hines, Rajiv Kumar

Journal: Biochem Biophys Res Commun

PubMed ID: 34332324

Doi: 10.1016/j.bbrc.2021.07.085

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Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand

Authors: Lauren H Carlton, Tiffany Chen, Alana L Whitcombe, Reuben McGregor, Greg Scheurich, Campbell R Sheen, James M Dickson, Chris Bullen, Annie Chiang, Daniel J Exeter, Janine Paynter, Michael G Baker, Richard Charlewood, Nicole J Moreland

Journal: Epidemiol Infect

PubMed ID: 34668464

Doi: 10.1017/S0950268821001643

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An MST4-pβ-Catenin Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Authors: Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao, Zhaocai Zhou

Journal: Adv Sci (Weinh)

PubMed ID: 34240584

Doi: 10.1002/advs.202004850

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Fine-tuning the expression of pathway gene in yeast using a regulatory library formed by fusing a synthetic minimal promoter with different Kozak variants

Authors: Liping Xu, Pingping Liu, Zhubo Dai, Feiyu Fan, Xueli Zhang

Journal: Microb Cell Fact

PubMed ID: 34320991

Doi: 10.1186/s12934-021-01641-z

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CRISPR/Cas9-mediated engineering of Escherichia coli for n-butanol production from xylose in defined medium

Authors: Ali Samy Abdelaal, Kamran Jawed, Syed Shams Yazdani

Journal: J Ind Microbiol Biotechnol

PubMed ID: 30982114

Doi: 10.1007/s10295-019-02180-8

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Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C

Authors: Zhongcheng Zhou, Peng Du, Meixing Yu, Daniel T. Baptista-Hon, Man Miao, Andy P. Xiang, Johnson Yiu-Nam Lau, COVID-19 Immunity Investigation Group, Gen Li, Kang Zhang

Journal: Signal transduction and targeted therapy

PubMed ID: 34315848

Doi: 10.1038/s41392-021-00695-0

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Development of an Immunochromatographic Strip Using Conjugated Gold Nanoparticles for the Rapid Detection of Klebsiella pneumoniae Causing Neonatal Sepsis

Authors: Noha M. Elhosseiny, Tamer M. Samir, Aliaa A. Ali , Amani A. El‐Kholy and Ahmed S. Attia

Journal: Pharmaceutics

PubMed ID: 34452099

Doi: 10.3390/pharmaceutics13081141

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Three optimized assays for the evaluation of compounds that can rescue p53 mutants

Authors: Jiale Wu, Huaxin Song, Zhengyuan Wang, Min Lu

Journal: STAR Protoc

PubMed ID: 34382015

Doi: 10.1016/j.xpro.2021.100688

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Effects of sevoflurane exposure during different stages of pregnancy on the brain development of rat offspring

Authors: Feng-He Cui, Jie Li, Ke-Zhong Li, Yong-Gang Xie, Xiao-Ling Zhao

Journal: J Anesth

PubMed ID: 34279702

Doi: 10.1007/s00540-021-02972-2

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Evaluation of a novel biomarker of type XXVIII collagen formation, PRO-C28, in samples from cancer and heart failure with preserved ejection fraction patients

Authors: Alexander L Reese-Petersen, Nicholas Willumsen, Patricia Palau, Julio Nunez, Shu Sun, Tina Manon Jensen, Bibi Kamall, Morten A Karsdal, Federica Genovese

Journal: J Pharm Biomed Anal

PubMed ID: 34358813

Doi: 10.1016/j.jpba.2021.114272

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Identification of a Novel Cleavage Site and Confirmation of the Effectiveness of NgAgo Gene Editing on RNA Targets

Authors: Jiayao Qu, Yali Xie, Zhaoyi Guo, Xiangting Liu, Jing Jiang, Ting Chen, Kai Li, Zheng Hu, Dixian Luo

Journal: Mol Biotechnol

PubMed ID: 34302285

Doi: 10.1007/s12033-021-00372-1

Products & Services: Nucleic Acid Purification & Analysis

HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

Authors: Hongfeng Yuan, Lina Zhao, Ying Yuan, Haolin Yun, Wei Zheng, Yu Geng, Guang Yang, Yufei Wang, Man Zhao, Xiaodong Zhang

Journal: Theranostics

PubMed ID: 34373747

Doi: 10.7150/thno.57531

Products & Services: Nucleic Acid Purification & Analysis

Long-chain polyphosphates impair SARS-CoV-2 infection and replication

Authors: Veronica Ferrucci, Dae-Young Kong, Fatemeh Asadzadeh, Laura Marrone, Angelo Boccia, Roberto Siciliano, Giuseppina Criscuolo, Camilla Anastasio, Fabrizio Quarantelli, Marika Comegna, Ida Pisano, Margherita Passariello, Ilaria Iacobucci, Rosa Della Monica, Barbara Izzo, Pellegrino Cerino, Giovanna Fusco, Maurizio Viscardi, Sergio Brandi, Bianca Maria Pierri, Giorgia Borriello, Claudia Tiberio, Luigi Atripaldi, Martina Bianchi, Giovanni Paolella, Ettore Capoluongo, Giuseppe Castaldo, Lorenzo Chiariotti, Maria Monti, Claudia De Lorenzo, Kyong-Seop Yun, Stefano Pascarella, Jae-Ho Cheong, Hong-Yeoul Kim, Massimo Zollo

Journal: Sci Signal

PubMed ID: 34230209

Doi: 10.1126/scisignal.abe5040

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Endocytosis of peroxiredoxin 1 links sterile inflammation to immunoparalysis in pediatric patients following cardiopulmonary bypass

Authors: Chia-Hsiung Liu, Zheng-Hua Huang, Shu-Chien Huang, Tzuu-Shuh Jou

Journal: Redox Biol

PubMed ID: 34332210

Doi: 10.1016/j.redox.2021.102086

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Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells

Authors: Dongzhi Wang, Yi Zhu, Yan Huang, Jiachen Zhu, Biwen Zhu, Yahong Zhao, Yuhua Lu, Zhiwei Wang, Yibing Guo

Journal: ACS Biomater Sci Eng

PubMed ID: 34251797

Doi: 10.1021/acsbiomaterials.1c00269

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Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells

Authors: Wei-Ching Chen, Minh D To, Peter M K Westcott, Reyno Delrosario, Il-Jin Kim, Mark Philips, Quan Tran, Saumya R Bollam, Hani Goodarzi, Nora Bayani, Olga Mirzoeva, Allan Balmain

Journal: Nat Commun

PubMed ID: 34257283

Doi: 10.1038/s41467-021-24498-7

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Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis

Authors: Yanzi Yan, Huiyi Liang, Xingliang Liu, Lixin Liu, Yongming Chen

Journal: Biomaterials

PubMed ID: 34293700

Doi: 10.1016/j.biomaterials.2021.121027

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Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179

Authors: Wolfrat Bachert, Lisa Klotz, Heinrich Sticht, Ralf Enz

Journal: Neurochem Int

PubMed ID: 34333057

Doi: 10.1016/j.neuint.2021.105150

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Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

Authors: Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, Pernille Poulsen, Jonathan Lou S Esguerra, Lena Eliasson, Allan Vaag, Olga Göransson, Charlotte Ling

Journal: Diabetes

PubMed ID: 34315727

Doi: 10.2337/db20-0324

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TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway

Authors: Da-Cen Lin, Si-Yi Zheng, Zhi-Guang Zhang, Jian-Hua Luo, Zhuang-Li Zhu, Li Li, Lu-Shan Chen, Xinjian Lin, James S K Sham, Mo-Jun Lin, Rui-Xiang Zhou

Journal: Cancer Lett

PubMed ID: 34311033

Doi: 10.1016/j.canlet.2021.07.038

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PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis

Authors: Zili Liu, Honglin Wang, Shaoqian Wang, Jie Gao, Lei Niu

Journal: Bone Joint Res

PubMed ID: 34254815

Doi: 10.1302/2046-3758.107.BJR-2020-0200.R2

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CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening

Authors: Jianghua Liu, Jiahui Chen, Di Wu, Mingquan Huang, Jian Chen, Ruiyuan Pan, Yongning Wu, Guoliang Li

Journal: Anal Chem

PubMed ID: 34278781

Doi: 10.1021/acs.analchem.1c01163

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Dual Targeting of Endoplasmic Reticulum by Redox-Deubiquitination Regulation for Cancer Therapy

Authors: Biao Cai, Mengfei Hou, Shijun Zhang, Zhixiang Xin, Jiwei Huang, Jingxing Yang, Yueming Wang, Xingyun Cai, Shaowei Xie, Chunfu Zhang, Yiran Huang

Journal: Int J Nanomedicine

PubMed ID: 34354353

Doi: 10.2147/IJN.S321612

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Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway

Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin, Xiaohua Liu

Journal: Reprod Biol Endocrinol

PubMed ID: 34266426

Doi: 10.1186/s12958-021-00796-z

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Latent tuberculosis co-infection is associated with heightened levels of humoral, cytokine and acute phase responses in seropositive SARS-CoV-2 infection

Authors: Anuradha Rajamanickam, Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Arul Nancy, Nandhini Selvaraj, Kushiyasri Karunanithi, Saravanan Munisankar, Shrinivasa Bm, Rachel Mariam Renji, T C Ambu, Vijayalakshmi Venkataramani, Subash Babu

Journal: J Infect

PubMed ID: 34329676

Doi: 10.1016/j.jinf.2021.07.029

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Structure of a mammalian sperm cation channel complex

Authors: Shiyi Lin, Meng Ke, Yuqi Zhang, Zhen Yan, Jianping Wu

Journal: Nature

PubMed ID: 34225353

Doi: 10.1038/s41586-021-03742-6

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Epitope-Paratope Interaction of a Neutralizing Human Anti-Hepatitis B Virus PreS1 Antibody That Recognizes the Receptor-Binding Motif

Authors: Jisu Hong, Youngjin Choi, Yoonjoo Choi, Jiwoo Lee, Hyo Jeong Hong

Journal: Vaccines (Basel)

PubMed ID: 34358170

Doi: 10.3390/vaccines9070754

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Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Authors: Gábor Wittmann, Malcolm J Low, Ronald M Lechan

Journal: Mol Metab

PubMed ID: 34329773

Doi: 10.1016/j.molmet.2021.101312

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Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation

Authors: Jialiang Shao, Tiezhu Shi, Hua Yu, Yufeng Ding, Liping Li, Xiang Wang, Xiongjun Wang

Journal: EMBO J

PubMed ID: 34269483

Doi: 10.15252/embj.2020107480

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Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia

Authors: Michael A Kiebish, Poornima Tekumalla, Shobha Ravipaty, Albert Dobi, Shiv Srivastava, Wenfang Wu, Saurabh Patil, Tracey Friss, Allison Klotz, Alagarsamy Srinivasan, Jennifer Cullen, Inger L Rosner, Amina Ali, Sandra Laszlo, Michele Petrovic, Neil Fleshner, Jeonifer Garren, Greg Miller, Nischal Mahaveer Chand, Leonardo O Rodrigues, Elder Granger, Mark D Kellogg, Shen Luan, Eleftherios Diamandis, Viatcheslav R Akmaev, Rangaprasad Sarangarajan, Chas Bountra, Stephen J Freedland, David G McLeod, Niven R Narain

Journal: Sci Rep

PubMed ID: 34302010

Doi: 10.1038/s41598-021-94438-4

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Hepta-Histidine Inhibits Tau Aggregation

Authors: Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazawa

Journal: ACS Chem Neurosci

PubMed ID: 34319089

Doi: 10.1021/acschemneuro.1c00164

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The importance of vitellogenin receptors in the oviposition of the pond wolf spider, Pardosa pseudoannulata

Authors: Zhi-Ming Yang, Tian-Yu Lu, Yong Wu, Na Yu, Guang-Ming Xu, Qian-Qian Han, Ze-Wen Liu

Journal: Insect Sci

PubMed ID: 34237799

Doi: 10.1111/1744-7917.12933

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High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins

Authors: Josefien W Hommes, Rachel M Kratofil, Sigrid Wahlen, Carla J C de Haas, Reeni B Hildebrand, G Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J A Korporaal, Bas G J Surewaard

Journal: Sci Rep

PubMed ID: 34321507

Doi: 10.1038/s41598-021-94651-1

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An octopamine receptor confers selective toxicity of amitraz on honeybees and mites

Authors: Lei Guo, Xin-Yu Fan, Xiaomu Qiao, Craig Montell, Jia Huang

Journal: Elife

PubMed ID: 34263722

Doi: 10.7554/eLife.68268

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Can commercial automated immunoassays be utilized to predict neutralizing antibodies after SARS-CoV-2 infection? A comparative study between three different assays

Authors: Ahmed Ismail, Farah M Shurrab, Hadeel T Al-Jighefee, Duaa W Al-Sadeq, Hamda Qotba, Ibrahim Abdu Al-Shaar, Hadi M Yassine, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Front Biosci (Landmark Ed)

PubMed ID: 34340267

Doi: 10.52586/4934

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Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI

Authors: Alireza Nomani, Geng Li, Siavash Yousefi, Shawn Wu, Obeid M Malekshah, Shahryar K Nikkhoi, Mehrdad Pourfathi, Rahim Rizi, Arash Hatefi

Journal: J Control Release

PubMed ID: 34284047

Doi: 10.1016/j.jconrel.2021.07.022

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Assays for studying normal suppressive ERAD-associated retrotranslocation pathways in yeast

Authors: Satarupa Bhaduri, Sonya E Neal

Journal: STAR Protoc

PubMed ID: 34278330

Doi: 10.1016/j.xpro.2021.100640

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Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry

Authors: Alessandra Luchini, Samantha Micciulla, Giacomo Corucci, Krishna Chaithanya Batchu, Andreas Santamaria, Valerie Laux, Tamim Darwish, Robert A Russell, Michel Thepaut, Isabelle Bally, Franck Fieschi, Giovanna Fragneto

Journal: Sci Rep

PubMed ID: 34290262

Doi: 10.1038/s41598-021-93996-x

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AstraZeneca (AZD1222) Covid 19 vaccine-associated adverse drug event: a case report

Authors: Capassoni Marco, Ketabchi Sheyda, Cassisa Angelo, Caramelli Riccardo, Molinu Antonietta Anna, Galluccio Felice, Guiducci Serena

Journal: J Med Virol

PubMed ID: 34214206

Doi: 10.1002/jmv.27175

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miR-29c-3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

Authors: Ruili Wang, Jie Yao, Fuhua Gong, Songsheng Chen, Ya He, Chunting Hu, Chen Li

Journal: Genes Cells

PubMed ID: 34086379

Doi: 10.1111/gtc.12877

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Development of a Bioluminescent Human Osteosarcoma Model in Humanized NSG Mice: A Pilot Study

Authors: Yunmi Ko, Yeon Ho Jeong, Jin-Hee Seo, Jun Ah Lee

Journal: In Vivo

PubMed ID: 34182491

Doi: 10.21873/invivo.12485

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Effective Antitumor of Orally Intestinal Targeting Penetrating Peptide-Loaded Tyroserleutide/PLGA Nanoparticles in Hepatocellular Carcinoma

Authors: Chenjun Ma, Tiantian Wei, Yingying Hua, Zhongjie Wang, Liefeng Zhang

Journal: Int J Nanomedicine

PubMed ID: 34239301

Doi: 10.2147/IJN.S315713

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P2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain

Authors: Yucui Jiang, Fan Ye, Ying Du, Yingxin Zong, Zongxiang Tang

Journal: J Inflamm Res

PubMed ID: 34239315

Doi: 10.2147/JIR.S313348

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Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-κB signalling

Authors: Mei Yang, Qishan Chen, Li Mei, Guanmei Wen, Weiwei An, Xinmiao Zhou, Kaiyuan Niu, Chenxin Liu, Meixia Ren, Kun Sun, Qingzhong Xiao, Li Zhang

Journal: Br J Pharmacol

PubMed ID: 34076894

Doi: 10.1111/bph.15583

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SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses

Authors: George W Carnell, Katarzyna A Ciazynska, David A Wells, Xiaoli Xiong, Ernest T Aguinam, Stephen H McLaughlin, Donna Mallery, Soraya Ebrahimi, Lourdes Ceron-Gutierrez, Benedikt Asbach, Sebastian Einhauser, Ralf Wagner, Leo C James, Rainer Doffinger, Jonathan L Heeney, John A G Briggs

Journal: J Virol

PubMed ID: 33963055

Doi: 10.1128/JVI.00203-21

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Overexpression of Douglas-Fir () in Induces Embryonic Programs and Embryo-like Structures in the Mutant but Not in Wild Type Plants

Authors: Mariana A Vetrici, Dmytro P Yevtushenko, Santosh Misra

Journal: Plants (Basel)

PubMed ID: 34451571

Doi: 10.3390/plants10081526

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Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process

Authors: Benjamin Petre, Mauricio P Contreras, Tolga O Bozkurt, Martin H Schattat, Jan Sklenar, Sebastian Schornack, Ahmed Abd-El-Haliem, Roger Castells-Graells, Rosa Lozano-Durán, Yasin F Dagdas, Frank L H Menke, Alexandra M E Jones, Jack H Vossen, Silke Robatzek, Sophien Kamoun, Joe Win

Journal: Plant Cell

PubMed ID: 33677602

Doi: 10.1093/plcell/koab069

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Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction

Authors: K N Westlund, M A Montera, A E Goins, S R A Alles, M Afaghpour-Becklund, R Bartel, R Durvasula, A Kunamneni

Journal: Neurobiol Pain

PubMed ID: 34458647

Doi: 10.1016/j.ynpai.2021.100067

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The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response

Authors: Bo Liu, Jiancheng Huang, Amina Ashraf, Oindrila Rahaman, Jing Lou, Ling Wang, Peiliang Cai, Jinping Wen, Shoaib Anwaar, Xiaoli Liu, Hai Ni, Dipyaman Ganguly, Jijun Zhao, Cliff Y Yang

Journal: Nat Commun

PubMed ID: 34215755

Doi: 10.1038/s41467-021-24352-w

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Genome-wide identification of candidate aquaporins involved in water accumulation of pomegranate outer seed coat

Authors: Jianjian Liu, Gaihua Qin, Chunyan Liu, Xiuli Liu, Jie Zhou, Jiyu Li, Bingxin Lu, Jianrong Zhao

Journal: PeerJ

PubMed ID: 34316414

Doi: 10.7717/peerj.11810

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