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Cholesterol analogs modulate lipid nanoparticle performance for mRNA delivery after lyophilization and enable ocular disease therapy

Authors: Ting Wang, Wanqi Li, Jianyang Chen, Sitian Cheng, Min Gao, Chengyu Jiang, Chengyu Jiang, Bingyi Hu, Tzu-Cheng Sung, Akon Higuchi

Journal: Materials Today Bio

Doi: 10.1016/j.mtbio.2026.103044

Products & Services: Custom mRNA synthesis

NIR-II Biomimetic Nanoplatform Optogenetic CD274 Editing of HNSCC Immunogenicity for Enhanced Photoimmunotherapy

Authors: Yang Chen, Longcai Liu, Xiaojuan Hu, Yilin Huang, Shijie Yao, Lichen Ji, Hai Zou, Xiaozhou Mou, Yu Cai

Journal: Materials Today Bio

Doi: 10.1016/j.mtbio.2026.102803

Products & Services: Synthetic Guide RNA CRISPR Plasmids

Oriented nanobody–field-effect transistor interfaces enable ultrasensitive cancer biomarker detection

Authors: Zhicheng Zhang, Duanlian Ye, Yuxuan Li, Guannan Li, Yanbo Jing, Jun Dai, Quan Wang, Tao Liu, Fan Xia, Xiaoding Lou

Journal: nature sensors

Doi: 10.1038/s44460-026-00040-4

Products & Services: Gene Synthesis

Y-shaped nanoprobe-based DNA microarray for rapid detection of multiplex miRNAs with single-nucleotide specificity

Authors: Yichen Du, Rui Sun, Shuang Hao, Fuwan Yang, Qifei Hu, Ruyan Xue

Journal: Microchemical Journal

Doi: 10.1016/j.microc.2026.117169

Products & Services: Custom DNA/RNA Oligos

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Authors: Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu

Journal: Advanced Science

PubMed ID: 41787915

Doi: 10.1002/advs.202520157

Products & Services: Protein Electrophoresis and Western

CRISPR/Cas9-Based Vanadium MXene-Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal-Induced Multi-Effect Synergistic Antitumor Therapy

Authors: Zi-Jian Huang, Feng-Ming Li, Yi-Fan Tu, Ke-Ke Feng, Cheng-Lei Li, Shi-Cheng Tian, Yong-Shan Hu, Jing-Wei Shao, Zhen-Hua Liu

Journal: Advanced Science

PubMed ID: 41818620

Doi: 10.1002/advs.202522535

Products & Services: Peptide Synthesis

Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy

Authors: Yan Wang, Fei Xu, Chengxiang Song, Xi Wang, Hao Zhou, Tianyi Qu, Hongde Li, Qiang Luo, Wenhua Lei, Yue Yin, Fangyang Huang, Mao Chen

Journal: Signal transduction and targeted therapy

PubMed ID: 41820291

Doi: 10.1038/s41392-026-02624-5

Products & Services: Custom mRNA synthesis

The mechanism of ribosomal recruitment during translation initiation on the Type 2 encephalomyocarditis virus IRES

Authors: Sayan Bhattacharjee, Irina S Abaeva, Zuben P Brown, Yani Arhab, Hengameh Fallah, Christopher U T Hellen, Joachim Frank, Tatyana V Pestova

Journal: The EMBO Journal

PubMed ID: 41851500

Doi: 10.1038/s44318-026-00735-x

Products & Services: Protein Electrophoresis and Western Mutagenesis Services

ZBTB16 controls the onset of Clostridium difficile colitis through the Pyrin inflammasome

Authors: Shuhui Li, Jingjing He, Huxidanmu Tuoheniyazi, Junrui Ma, Zhenyu Li, Juanjuan Zheng, Yuxin Wang, Xiupan Gao, Xiaobao Yang, Danping Liu, Yanan Zhao, Tongxuan Su, Yibing Peng, Dakang Xu, Xuefeng Fei

Journal: Pharmacological research

PubMed ID: 41666999

Doi: 10.1016/j.phrs.2026.108133

Products & Services: Protein Electrophoresis and Western

89Zr/177Lu-Labeled Radioimmunoconjugates Targeting SORT1 for Cancer Theranostics

Authors: Jingyue Gao, Tianyi Cen, Junyi Chen, Xinwei Li, Xiaowei Fan, Mengxin Xu, Feng Gao, Zhibo Liu

Journal: Journal of medicinal chemistry

PubMed ID: 41773941

Doi: 10.1021/acs.jmedchem.6c00007

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Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors

Authors: Jiacheng Deng, Jian Zhou, Hongyong Xiang, Xueyuan Li, Xiang Han, Zhen Weng, Junbo Jia, Yingshuo Shao, Yang Sima, Ming Niu, Dongmeng Li, Hongsheng Ouyang, Bin Xu, Daxin Pang, Lin Yang, Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 41909950

Doi: doi.org/10.1093/nar/gkag162

Products & Services: Gene Synthesis Codon Optimization

Ferrous fluoride nanoinitiators reprogram tumor stemness to empower ultrasound-augmented pyroptosis for potent catalytic immunotherapy

Authors: Shumin Sun, Nailin Yang, Jihu Nie, Zifan Pei, Chunjie Wang, Zixian Yang, Zhihui Han, Yichi Cai, Liang Cheng

Journal: Biomaterials

PubMed ID: 40885147

Doi: 10.1016/j.biomaterials.2025.123652

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Sertoli Cell-Derived Extracellular Vesicles Orchestrate Cadmium-Induced Testicular Inflammation and Fibrosis

Authors: Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen

Journal: Advanced Science

PubMed ID: 41881035

Doi: 10.1002/advs.202522278

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Chemoenzymatic synthesis of K29/K48-branched ubiquitin chains using LbPro* andOaAEP1 enzymes

Authors: Hongyi Cai, Xiangwei Wu, Shidian Wu, Lei Liu, Man Pan

Journal: CCS Chemistry

Doi: 10.31635/ccschem.026.202506451

Products & Services: Protein Electrophoresis and Western

Elucidating the Molecular Mechanism of 3D1 Antibody Binding to a Swine Enteric Coronavirus Antigen

Authors: Liangminghui Zhang, Ze Liang, Guang Yang, Lei Yan

Journal: Viruses

PubMed ID: 41754551

Doi: 10.3390/v18020208

Products & Services: Peptide Synthesis

ITGB1 Regulates Triple-Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Authors: Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T Rosen, Yingyu Wang, Chun-Wei D Chen, Cheng Zhang, Mingye Feng

Journal: Advanced Science

PubMed ID: 41632816

Doi: 10.1002/advs.202513672

Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

Authors: Han Wu, Qing Shui, Xiaoxi Luan, Kexin Wang, Wei Zhao, Xiaopeng Qi, Bingyu Liu, Wanwei Sun, Chengjiang Gao

Journal: Molecular Therapy

PubMed ID: 41678331

Doi: 10.1016/j.celrep.2026.116976

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An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation and osteoporotic fracture repair

Authors: Jie Zhao, Zengliang Wang, Lina Lu, Guoyun Bu, Zukang Miao, Yang Zhang, Yue Guo, Zhao Yang, Jianxiong Ma, Jun Jiao, Xinlong Ma

Journal: Molecular Therapy

PubMed ID: 41679307

Doi: 10.1016/j.crmeth.2025.101299

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Authors: Jiawei Xiao, Donghua Guo, Xiaoxu Xing, Limin Jiang, Shanshan Qi, Jun Wang, Wenfei Bai, Shiping Yu, Fanbo Shen, Xingyang Guo, Xinglin Wang, Wei Zhou, Hansong Li, Feiyu Zhao, Li Feng, Jialin Zhang, Yaru Xu, Dan Yang, Haixin Liu, Dongbo Sun

Journal: Molecular Therapy

PubMed ID: 41720346

Doi: 10.1016/j.virs.2026.02.011

Products & Services: Peptide Synthesis

Taming immune responses to AAV gene therapy by programmed in vivo Treg expansion

Authors: Lavesh Gwalani, Mincheol Park, Alexandra B Ysasi, Mona Motwani, Robert Jackson, Jie Bu, Zhengyu Luo, John Bladon, Edith L Pfister, Christian Mueller, Sourav R Choudhury

Journal: Molecular Therapy

PubMed ID: 41691369

Doi: 10.1016/j.ymthe.2026.02.019

Products & Services: Peptide Library Services

Protein delivery to the eye: assessing therapeutic potential across inner and outer retina

Authors: Giuditta Dal Cortivo, Carmen Longo, Brigitte Müller, Anna Avesani, Raffaella Pacchiana, Maria Weller, Valerio Marino, Lyubomyr Lytvynchuk, Knut Stieger, Daniele Dell'Orco

Journal: International journal of pharmaceutics

PubMed ID: 41500346

Doi: doi.org/10.1016/j.ijpharm.2026.126568

Products & Services: PCR Cloning and Subcloning

From Field Overexpression to Biochemical Function: PxCYP6B4 Mediated Hydroxylation Confers Pyrethroid Resistance in Plutella xylostella

Authors: Zhuoda Liu, Yifei Zhou, Dongliang Wang, Ruichi Li, Zhen Tian, Yifan Li, Jiyuan Liu

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 41645610

Doi: 10.1021/acs.jafc.6c00843

Products & Services: Gene Synthesis Codon Optimization

Disrupted energy metabolism is associated with retinal ganglion cell degeneration in autosomal dominant optic atrophy

Authors: Eugene Yu-Chuan Kang, Yun-Ju Tseng, Wei-Hao Peng, Hui-Chuan Hung, Pei-Hsuan Lin, Katrina P Montales, Emmet Sherman, John Peregrin, Ethan Hunghsi Wang, Chunya Kang, Yu-Chuan Teng, Chen-Yang Huang, Chia-Lung Tsai, Ian Yi-Feng Chang, Jiazhang Chen, Gülgün Tezel, Ye He, Tai-De Li, Linsey Stiles, Orian Shirihai, Stephen H Tsang, Chi-Chun Lai, Chi-Neu Tsai, Chyuan-Sheng Lin, Nan-Kai Wang

Journal: SCIENCE ADVANCES

PubMed ID: 41706861

Doi: 10.1126/sciadv.adx7815

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Attenuation of Influenza a Virus into Live Vaccines Through C-End Degrons

Authors: Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen-Xia Tian, Longlong Si

Journal: Advanced Science

PubMed ID: 41721587

Doi: 10.1002/advs.202509425

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E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines

Authors: Jeongmin Hwang, Tonatiuh A Ocampo, Vinzenz Mayer, Janice Kang, Krishna S Paranandi, Young Jun Kim, Zhenyu Han, John P Cavaliere, Sergej Kudruk, Jochen H Lorch, Chad A Mirkin

Journal: SCIENCE ADVANCES

PubMed ID: 41671353

Doi: 10.1126/sciadv.aec3876

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Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

Authors: Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L V Bader, Ryan H Lim, Krystal M Ma, Christopher A Cottrell, Jon M Steichen, Liling Xu, Paula M Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Ming Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel D Allen, Ali A Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Jordan Renae Ellis-Pugh, Nushin Alavi, Abigail Esposito, Hannah Naili, Nicole Phelps, Brendon Kelley, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, Xiaotie Liu, John E Warner, Stephanie R Weldon, Sunny Himansu, Max Crispin, Usha Nair, Sophia Liu, William R Schief, Facundo D Batista

Journal: Immunity

PubMed ID: 41690309

Doi: 10.1016/j.immuni.2026.01.011

A near-complete map of human cytosolic degrons and their relevance for disease

Authors: Vasileios Voutsinos, Kristoffer E Johansson, Fia B Larsen, Martin Grønbæk-Thygesen, Nicolas Jonsson, Emma Holm-Olesen, Giulio Tesei, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: SCIENCE ADVANCES

PubMed ID: 41650254

Doi: 10.1126/sciadv.adz3483

Selective Targeting of Immune Checkpoints HLA-G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Authors: Lisa J Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer

Journal: Advanced Science

PubMed ID: 41662489

Doi: 10.1002/advs.202521448

Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1

Authors: Francisco G Sanchez-Conde, Matthew R Goodrich, Olivia M Stack, Louis N R Goldberg, Pamela K Ruzycki, Abhilasha Jain, Eric N Jimenez-Vazquez, David K Jones

Journal: Molecular Therapy

PubMed ID: 41708004

Doi: 10.1016/j.jbc.2026.111296

Products & Services: Mutagenesis Services

AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPKMTOR-autophagy pathway in macrophage

Authors: Rui Chao, Lei Sun, Xinyu Xu, Zhan Liu, Xinyi Xu, Zhen Ren, Xinwei Chen, Weifeng Xu, Xuzhuo Chen, Ying Hu, Shanyong Zhang

Journal: Journal of nanobiotechnology

PubMed ID: 41634773

Doi: 10.1186/s12951-026-04080-3

Products & Services: Protein Electrophoresis and Western

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

Authors: Anuj Kumar, Emmanuel Combe, Elena M Smekalova, Selam Dejene, Dominique Leboeuf, Chao-Ying Chen, Léa Mougené, Marine Deleume, Caroline Scholtes, Marie-Laure Plissonnier, Xavier Grand, Maria G Martinez, Giuseppe Ciaramella, Francine Gregoire, Michael S Packer, Barbara Testoni, Fabien Zoulim

Journal: bioRvix

PubMed ID: 41676540

Doi: 10.64898/2026.02.06.704371

Products & Services: PCR Cloning and Subcloning

Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

Authors: Ziyu Zhang, Man Wang, Fangzhi Tan, Liyan Zhang, Xiaohan Wang, Xiangyan Chen, Jia Han, Nianci Li, Qiuhan Sun, Yicheng Lu, Zhiping Cui, Zuhong He, Jieyu Qi, Renjie Chai

Journal: Med

PubMed ID: 41763223

Doi: 10.1016/j.medj.2026.101001

Products & Services: Protein Electrophoresis and Western

A novel two-component system regulates shikimate pathway for thermal adaptation in Thermus thermophilus

Authors: Xuying Bu, Yuwen Guo, Xiangyu Tian, Yuan Shao, Changyou Li, Pan Zhang, Yunxiang Liang, Yingjun Li

Journal: Nucleic Acids Research

PubMed ID: 41693563

Doi: 10.1093/nar/gkag116

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The RNA methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) on IL1B mRNA to promote transcript stability

Authors: Jiayun Wang, Lingyan Yan, Rong Jia, Jihua Guo

Journal: Molecular Therapy

PubMed ID: 41707999

Doi: 10.1016/j.jbc.2026.111290

Products & Services: Protein Electrophoresis and Western

A Specific Sinorhizobium Flagellin Suppresses Legume Nodulation Through Immune Activation

Authors: Li Liu, Yaohua Li, Shuangcheng Ye, Chuanzheng Wei, Ziang Yan, Huanhui Yang, Hui Zhu, Gary Stacey, Yangrong Cao

Journal: Plant Biotechnology Journal

PubMed ID: 41636391

Doi: 10.1111/pbi.70576

Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors

Authors: Joseph J Porter, Wooree Ko, Emily G Sorensen, Zachary Cheung, Kari Thrasher, Tyler Couch, Jeffrey T Gabell, Victoria Shwe, Julia Hyatt, Jennasea B Licata, Luke K Peterson, David A Dean, John D Lueck

Journal: Nucleic Acids Research

PubMed ID: 41641696

Doi: 10.1093/nar/gkag082

Divergent stem cell mechanisms govern the primary body axis and appendage regeneration in the axolotl

Authors: Liqun Wang, Li Song, Chao Yi, Jing Zhou, Zhouying Yong, Yan Hu, Xiangyu Pan, Na Qiao, Hao Cai, Wandong Zhao, Rui Zhang, Lieke Yang, Lei Liu, Guangdun Peng, Elly M Tanaka, Hanbo Li, Yanmei Liu, Ji-Feng Fei

Journal: SCIENCE ADVANCES

PubMed ID: 41650255

Doi: 10.1126/sciadv.adx5697

Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex

Authors: Hao-Chi Hsu, Isabelle Bonnet, Ruslana Bryk, Huilin Li

Journal: Molecular Therapy

PubMed ID: 41690596

Doi: 10.1016/j.jbc.2026.111284

Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist

Authors: Eric Gibbs, Bjarne Feddersen, Kayla J Kindig, David Seiferth, Philip C Biggin, Sudha Chakrapani

Journal: SCIENCE ADVANCES

PubMed ID: 41686897

Doi: 10.1126/sciadv.aeb2036

Genome-Wide Identification, Characterization, Expression Analysis, and Interacting Protein Prediction of the GSK3/Shaggy-like Gene Family in Watermelon

Authors: Peng Tian, Jingjing Zhang, Bowen Liu, Xiurui Gao, Bing Li, Wei Liu and Yanrong Wu

Journal: Plants-Basel

Doi: 10.3390/plants15030484

Products & Services: Gene Synthesis

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Authors: Lyuba Y Salih, Nicolas L A Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P Moritz, Yannick Tholance, Jean-Philippe Camdessanché, Jean-Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François-Moutal, Aubin Moutal

Journal: Advanced Science

PubMed ID: 41700748

Doi: 10.1002/advs.202511413

MicroRNA-375-3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Authors: Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li

Journal: Advanced Science

PubMed ID: 41674346

Doi: 10.1002/advs.202513486

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Unified modeling of 3D molecular generation via atomic interactions with PocketXMol

Authors: Xingang Peng, Ruihan Guo, Fenglin Guo, Ziyi Wang, Jiayu Sun, Jiaqi Guan, Yinjun Jia, Yan Xu, Yanwen Huang, Muhan Zhang, Jian Peng, Xinquan Wang, Chuanhui Han, Zihua Wang, Jianzhu Ma

Journal: Cell

PubMed ID: 41713417

Doi: 10.1016/j.cell.2026.01.003

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Systematic analysis of functional genetic and epigenetic variants in colorectal cancer

Authors: Erfei Chen, Qiqi Yang, Haoyang Dai, Yixin Chen, Yihui Zhang, Qianglong Wang, Rongrong Hou, Ming Chen, Jie Wang, Qianwen Xie, Wenju Sun, Yong-Qiang Ning, Ligang Fan, Jian Yan

Journal: SCIENCE ADVANCES

PubMed ID: 41719390

Doi: https://doi.org/10.1126/sciadv.aeb2473

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A tripartite AAV System with Engineered Lox Sites Enables Efficient Delivery of the EYS Gene for Retinal Gene Therapy

Authors: Kun-Do Rhee, Poppy Datta, Clairissa Baccam, Seongjin Seo

Journal: Human gene therapy

PubMed ID: 41714294

Doi: 10.11710430342261426597

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OsWRKY53-OsGT1 Module Regulates Rice Tiller Development and Is Involved in Fine-Tuning Strigolactone Signaling

Authors: Jiaqi Tang, Guilong Zhao, Jiangli Yang, Zhuo Chen, Zhipeng Hong, Xin Jin, Ziming Qiu, Zhenyu Wang, Xiufeng Li, Jijun Yan, Changhua Liu, Weiqiang Li, Jinfang Chu, Yuanhu Xuan, Xiaojie Tian, Qingyun Bu

Journal: Plant Biotechnology Journal

PubMed ID: 41641886

Doi: 10.1111/pbi.70578

Products & Services: Protein and Antibody Isolation

Rapid discovery of repurposed drugs targeting SARS-CoV-2 spike HR1 by DNA-encoded library screening

Authors: Qingao Xue, Ze Liang, Yi Zhang, Fei Wang, Fulian Wang, Lili Liu, Guang Yang, Lei Yan

Journal: Bioorganic Chemistry

PubMed ID: 41691755

Doi: 10.1016/j.bioorg.2026.109627

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PD-L1-Binding Antigen Presenters: Redirecting Vaccine-Induced Antibodies for Cancer Immunotherapy

Authors: Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou

Journal: Advanced Science

PubMed ID: 41668552

Doi: 10.1002/advs.202519574

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cPLA2α targeting to exosomes connects nuclear deformation to LTB4-signaling during neutrophil chemotaxis

Authors: Subhash B Arya, Fatima Jordan-Javed, Kristen Loesel, Yehyun Choi, Samuel P Collie, Lauren E Hein, Brendon M Baker, Euisik Yoon, Carole A Parent

Journal: SCIENCE ADVANCES

PubMed ID: 41719396

Doi: 10.1126/sciadv.aea2784

Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer

Authors: Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr, Jangho Park, Yangxi Zheng, Long T Vien, Khalida M Wani, Huamin Wang, Sisi Gao, Tim Heffernan, Lawrence Kwong, Ignacio I Wistuba, Laura Bover, Giulio F Draetta, Haoqiang Ying, Wantong Yao

Journal: Molecular Therapy

PubMed ID: 41707651

Doi: 10.1016/j.xcrm.2026.102613

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

Authors: Gauri Deák, Hayden Burdett, James A Watson, Marcus D Wilson

Journal: Molecular Therapy

PubMed ID: 41709455

Doi: 10.1016/j.str.2026.01.008

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A novel alphavirus-based saRNA platform for enhanced vaccination efficacy and organ-specific targeting

Authors: Zhen Sun, Yuxiao Liu, Haoyi Zhang, Ting Ge, Yuting Pan, Yang Liu, Miaomiao Wu, Tao Shan, Guoqiang Zhu, Qi Wu, Kangming Chen

Journal: Vaccine

PubMed ID: 41349243

Doi: 10.1016/j.vaccine.2025.128055

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Ultrafast and Green Encapsulation of Enzymes in Biotitania Nanoparticles via Elastin-like Polypeptide-Mediated Biomimetic Mineralization

Authors: Lin, Yuanqing; He, Yichen; He, Ziyun; Zhan, Weichen; Huang, Yidan; Li, Xue; Cai, Jinzhong; Chen, Lanfang; Xiao, Zushun; Liu, Xingxing; Zhang, Guangya

Journal: ACS Sustainable Chemistry & Engineering

Doi: 10.1021/acssuschemeng.5c12382

Products & Services: Protein Electrophoresis and Western

Humanization and engineering of protective antibodies targeting severe fever with thrombocytopenia syndrome virus Gn protein

Authors: Xuanxiu Ren, Wei Deng, Feiyang Yu, Wenhua Kuang, Heya Na, Shangyu Yang, Jiawen Sun, Jianlun Xu, Bo Shu, Sheng Cao, Xianliang Ke, Zengqin Deng, Yun-Jia Ning, Haiyan Zhao

Journal: Cell Reports

PubMed ID: 41671090

Doi: 10.1016/j.celrep.2026.116936

Products & Services: Protein and Antibody Isolation

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency

Authors: Zexiong Lin, Yuan Li, Yu Zhao, Dongteng Liu, Shuzi Deng, Jingkai Gu, Yanyan Li, Xudong Zhao, Peishan Wu, Yuan Xiao, Jiaping Su, Yiting Sun, Yihui Zhang, Yin Lau Lee, Yorino Sato, Haitao Zeng, Haonan Lu, Juanhui Zhang, Jennifer K Y Ko, Jing Zhao, Kazuhiro Kawamura, Ernest H Y Ng, Shanfang Jiang, Yu Li, Xi Xia, Karen K L Chan, William S B Yeung, Tianren R Wang, Kui Liu

Journal: Science

PubMed ID: 41643022

Doi: 10.1126/science.adz4075

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Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform

Authors: Simon Christian Vinther, Antonia Resag, Karina Thao Thu Le, Claudia Christine Zelle-Rieser, Helen Strandt, Mette Galsgaard Malle, Stig Hill Christiansen, Barbara Del Frari, Theresia Stigger, Bastian Schilling, Jonas Wohlfarth, Steffen Thiel, Julián Valero, Patrizia Stoitzner, Jørgen Kjems

Journal: Molecular Therapy

PubMed ID: 41713595

Doi: 10.1016/j.jconrel.2026.114741

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Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity

Authors: Jacek Kędzierski, Rianne E van Diest, Julien A Allard, Andreas M Erharter, Alex Odermatt, Martin Smieko

Journal: Molecular Therapy

PubMed ID: 41722875

Doi: 10.1016/j.toxlet.2026.111859

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The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma

Authors: Brian D Tran, Irene Peris, Ethan Wurman, Averie Huang, Gabrielle Hodges Onishi, Jiang Hu, Rita A Avelar, Erika A Newman, Analisa DiFeo, Caitlin M O'Connor, Goutham Narla

Journal: Molecular Therapy

PubMed ID: 41707997

Doi: 10.1016/j.jbc.2026.111298

Expression of IMD-CBM peptide induces the autophagic degradation of CAV1 (caveolin 1) to inhibit LDL transcytosis and retard diabetic atherosclerosis

Authors: Li Wang, Xiong Jia, Xiangli Bai, Ying Zhao, Wenzhuo Cheng, Meng Shu, Yan Shu, Liyin Zhang, Ruonan Wang, Si Jin

Journal: Autophagy

PubMed ID: 41686177

Doi: 10.1080/15548627.2026.2631946

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE-Secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Authors: Shi-Wei Huang, Yu-Chuan Lin, Chih-Ming Pan, Yeh Chen, Ming-You Shie, Cheng-Yu Chen, Kai-Wen Kan, Yi-Wen Chen, Ming-Chao Liu, Chung-Chun Wu, Yu-Ting Chiang, Huai-Ping Ho, Chen-Yu Lin, Pei-Ying Lin, Yu-Han Huang, Steffany Rusli, Wan-Yu Mao, Pei-Wen Huang, Sin-Ting Wang, Wan-Chen Tsai, Ya-Hsu Chiu, Ting-Hsun Lin, Wan-Ling Chiang, Che-Kai Chang, Zi-Lun Lai, Mei-Chih Chen, Shao-Chih Chiu, Der-Yang Cho

Journal: Advanced Science

PubMed ID: 41632088

Doi: 10.1002/advs.202519440

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates

Authors: Ignacio Relano-Rodriguez, Jianqiu Du, Zi Jie Lin, Margaret Kerwin, Marta Tarquis-Medina, Eduardo Urbano, Jiayan Cui, Meagan Watkins, Christy L Lavine, Peng Zhao, Rumi Habib, Colby Agostino, Sukanya Ghosh, Joyce Park, Caroline Boroughs, Agnes A Walsh, Mariane B Melo, Niharika Shukla, George M Shaw, Beatrice H Hahn, Darrell J Irvine, Lance Wells, David B Weiner, Michael S Seaman, Daniel W Kulp, Ronald S Veazey, Jesper Pallesen, Amelia Escolano

Journal: nature immunology

PubMed ID: 41634485

Doi: 10.1038/s41590-025-02408-z

Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing

Authors: Yan Zong, Haiping Zhong, Yuqing Wang, Yi Lin, Linxi Zhao, Xiaoyu Wang, Jianan Cai, Haoyang Lin, Yixi Xiao, Tuo Wei, Shutao Guo, Qiang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 41733506

Doi: 10.1021/jacs.6c01708

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Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles

Authors: Jacob R Enriquez, Zhengjie Zhou, Jennifer B Nelson, Fei Huang, Kayla T Figatner, Advaita Chakraborty, Sarida Pratuangtham, Brian Xi, Sarah C May, Matthew V Tirrell, Sarah A Tersey, Yun Fang, Raghavendra G Mirmira

Journal: Molecular Therapy

PubMed ID: 41722565

Doi: 10.1016/j.xcrm.2026.102634

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KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors

Authors: Huimin Shao, Fei Xu, Jiangyue Xu, Lingjie Zhou, Yao Wu, Lianjun He, Xueyi Qian, Weijie He, Nanlin Jiao, Yabin Xia, Jun Zhao, Lili Sheng, Guoliang Mao, Tao Ma, Wei Wang, Shaoxiang Luo, Li Fu, Zhenyu Xu

Journal: SCIENCE ADVANCES

PubMed ID: 41719389

Doi: 10.1126/sciadv.aea2511

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Functional characterization of secreted Schistosoma mansoni serpin SmSPI reveals Factor XIIa inhibition as evidenced by biochemical, and human plasma assays and supported by AI-assisted structural modelling

Authors: Lukáš Konečný, Kristýna Peterková, Ingrid Hrachovinová, Alex Loukas, Tomáš Macháček, Jan Dvořák, Lucie Jedličková

Journal: Molecular Therapy

PubMed ID: 41724421

Doi: 10.1016/j.ijpara.2026.104808

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Authors: Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue

Journal: Advanced Science

PubMed ID: 41637534

Doi: 10.1002/advs.202505240

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Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities

Authors: Sivan Kaminski Strauss, Ruthie Golomb, Donya Khoury, Noa Aharon-Hefetz, Hadar Meyer, Dayag Sheykhkarimli, Gianni Liti, Orna Dahan, Yitzhak Pilpel

Journal: Molecular Therapy

PubMed ID: 41689801

Doi: 10.1016/j.celrep.2026.116972

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Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells

Authors: Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu

Journal: Nucleic Acids Research

PubMed ID: 41728952

Doi: 10.1093/nar/gkag112

Human DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

Authors: Natália C Moreno, Emilie J Korchak, Marcela T Latancia, Dana A D'Orlando, Temidayo Adegbenro, Ryan P Barnes, Irina Bezsonova, Roger Woodgate, Nicholas W Ashton

Journal: Nucleic Acids Research

PubMed ID: 41693564

Doi: 10.1093/nar/gkag098

Engineering New-to-Nature Biological Pathways for β,γ-Alkanediol Synthesis

Authors: Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan

Journal: Advanced Science

PubMed ID: 41677379

Doi: 10.1002/advs.202519742

PolyP inhibits CobB deacetylase triggering a regulatory coupling to prevent DNA replication initiation

Authors: Ewelina Boguszewska, Zuzanna Hirsz, Magdalena Sroka, Katarzyna Bury, Weronika Chmura, Agnieszka Strzałka, Marta Kołodziej, Jolanta Zakrzewska-Czerwińska, Igor Konieczny

Journal: Nucleic Acids Research

PubMed ID: 41728951

Doi: 10.1093/nar/gkag144

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo

Journal: Advanced Science

PubMed ID: 41521460

Doi: 10.1002/advs.202515724

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Structural basis for the subtype-selectivity of KCa2.2 channel activators

Authors: Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A Nasburg, Dohyun Im, Meng Cui, K George Chandy, Heike Wulff, Miao Zhang

Journal: Nature Communications

PubMed ID: 41507196

Doi: 10.1038/s41467-025-67232-3

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A disulfide redox switch mechanism regulates glycoside hydrolase function

Authors: Marcele Pandeló Martins, Gustavo Henrique Martins, Felipe Jun Fuzita, João Paulo Menezes Spadeto, Renan Yuji Miyamoto, Felippe Mariano Colombari, Fabiane Stoffel, Luciano Graciani Dolce, Camila Ramos Dos Santos, Rodrigo Silva Araujo Streit, Antônio Carlos Borges, Rafael Henrique Galinari, Yoshihisa Yoshimi, Paul Dupree, Gabriela Felix Persinoti, Mariana Abrahão Bueno Morais, Mario Tyago Murakami

Journal: Nature Communications

PubMed ID: 41491304

Doi: 10.1038/s41467-025-67225-2

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Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy

Authors: Xianjun Li, Xuehan Li, Jiaqi Shi, Yingjing Li, Hanyu Zhang, Tianjun Chen, Hui Pang, Shuyuan Zhang, Shengnan Luo, Fengyi Liu, Shuang Li, Chujie Ding, Linlin Sun, Fan Xing, Tongsen Zheng

Journal: Nature biomedical engineering

PubMed ID: 41501251

Doi: 10.1038/s41551-025-01575-6

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Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenza

Authors: Matthew R Ykema, Michael A Davis, Darshan N Kasal, Madeleine F Jennewein, Ethan Lo, Jasneet Singh, Samuel Beaver, Noah Cross, Eduard Melief, Sierra Reed, Christopher Press, Devin S Brandt, Wynton D McClary, Raodoh Mohamath, Pauline Fusco, Julie Bakken, Corey Casper, Airn Tolnay Hartwig, Alana Gerhardt, Richard A Bowen, Emily A Voigt

Journal: Nature Communications

PubMed ID: 41530119

Doi: 10.1038/s41467-025-64829-6

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Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion

Authors: Haifeng Zhang, Renjie Shang, Zheng Zhang, Min Zhou, Anne Bigot, Yanqing Cai, Yanran Zhao, Yushu Wang, Aaryahi Deshmukh, Elena Kudryashova, Dmitri S Kudryashov, Cuiyu He, Vincent Mouly, Pengpeng Bi

Journal: Nature Communications

PubMed ID: 41540035

Doi: 10.1038/s41467-025-67583-x

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Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase

Authors: Na Wang, Fanjia Hou, Sihui Ma, Silan Liu, Haimei Wei, Weicheng Fang, Ke Zhang, Yun Ge

Journal: Nature Communications

PubMed ID: 41501012

Doi: 10.1038/s41467-025-66689-6

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Human FcRL5 is an Fc receptor that simultaneously engages two IgGs

Authors: Shihua Chen, Shuhan Li, Zhiying Zhang, Junyu Xiao

Journal: SCIENCE ADVANCES

PubMed ID: 41477863

Doi: 10.1126/sciadv.aeb8865

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A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS-STING Activation for Cancer Immunotherapy

Authors: Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang

Journal: Advanced Science

PubMed ID: 41560305

Doi: 10.1002/advs.202518356

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Structure-Guided Engineering of a Cas12i Nuclease Unlocks Near-PAMless Genome Editing

Authors: Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian-Kang Zhu

Journal: Advanced Science

PubMed ID: 41532605

Doi: 10.1002/advs.202516670

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Argonaute-mediated RNA editing selectively repairs point mutations

Authors: Zhiwei Zhang, Jinyue Wang, Tongyu Guo, Xiaolan Yu, Fei Wang, Hang Zhang, Yang Liu, Wenqiang Li, Yibin Cheng, Yanhong Peng, Guangbo Yan, Jiakai Cui, Lixin Ma

Journal: Nucleic Acids Research

PubMed ID: 41495892

Doi: 10.1093/nar/gkaf1403

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Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase

Authors: Meimei Lan, Li Xu, Yizhen Han, Tong Cui, Zhi Qiao, Yan-Bin Teng, Na Wang, Hongyu Bao

Journal: Nucleic Acids Research

PubMed ID: 41495901

Doi: 10.1093/nar/gkaf1492

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A High Soluble-Fibre Allele in Wheat Encodes a Defective Cell Wall Peroxidase Responsible for Dimerization of Ferulate Moieties on Arabinoxylan

Authors: Rowan A C Mitchell, Ondrej Kosik, Abdul Kader Alabdullah, Anneke Prins, Maria Oszvald, Till K Pellny, Jackie Freeman, Kirstie Halsey, Caroline A Sparks, Alison Huttly, James Brett, Michelle Leverington-Waite, Simon Griffiths, Peter R Shewry, Alison Lovegrove

Journal: Plant Biotechnology Journal

PubMed ID: 41482806

Doi: 10.1111/pbi.70527

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Structure and function of the nairovirus cap-snatching endonuclease

Authors: Wenhua Kuang, Zhenhua Tian, Gan Zhang, Fan Wu, Jinyue Li, Jingjing Tang, Huanyu Zhang, Xinyue Zhuo, Zhihong Hu, Manli Wang, Haiyan Zhao, Zengqin Deng

Journal: Nucleic Acids Research

PubMed ID: 41533578

Doi: 10.1093/nar/gkaf1515

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Strategic variations in sarbecovirus and merbecovirus Nsp1 linker regions for translation inhibition

Authors: Ruixi Yan, Mingbo Wu, Xiangyu Ge, Qianqian Jin, Moyu Wang, Haolong Zhou, Yan Li, Yue Wang, Shuai Yuan

Journal: Nucleic Acids Research

PubMed ID: 41538319

Doi: 10.1093/nar/gkag017

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From Natural Discovery to AI-Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Authors: Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu

Journal: Advanced Science

PubMed ID: 41486594

Doi: 10.1002/advs.202516600

Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility

Authors: Sixian Qi, Lifan Wei, Zhan Ding, Feiya Zhong, Sicong Yang, Leibin Wu, Xuan Yang, Bin Kang, Mo Dan, Jianhua Gan, Chunlei Li, Xiaoye Su

Journal: SCIENCE ADVANCES

PubMed ID: 41481737

Doi: 10.1126/sciadv.adu6505

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Wnt3a promotes in situ dentin formation through NKD1- MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells

Authors: Haoran Du, Qiong Li, Chenchen Zhou, Junji Xu, Kang Gao, Zixiao Li, Yifan Xu, Ousheng Liu, Bing Li, Jianguang Xu, Jingsong Wang, Hideaki Kagami, Xianqi Li, Su Chen, Jian Zhou

Journal: International journal of oral science

PubMed ID: 41526338

Doi: 10.1038/s41368-025-00406-3

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In Vivo Generation and Manipulation of CAR-T-mimicking Cells via Magnetic Bispecific Nano-antibody for Solid Tumor Therapy

Authors: Yueqiang Zhu, Chaoran Chen, Junbin Chen, Miao Su, Wanling Huang, Sichen Liu, Mingda Yang, Chengqiong Mao, Song Shen, Xianzhu Yang, Jun Wang

Journal: Advanced materials (Deerfield Beach, Fla.)

PubMed ID: 41495981

Doi: 10.1002/adma.202520493

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A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

Authors: Shanshan Yu, Qiyao Chai, Zhe Lu, Changgen Qiu, Yanzhao Zhong, Yiru Wang, Zehui Lei, Lihua Qiang, Yingxu Fang, Xinwen Zhang, Bingxi Li, Mengqiu Gao, Lingqiang Zhang, Gong Cheng, Jing Wang, Cui Hua Liu, Yu Pang

Journal: Cell Host & Microbe

PubMed ID: 41475336

Doi: 10.1016/j.chom.2025.12.002

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Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors: S Haydar, R Bednarz, P Laurette, I Sobitov, N Díaz I Pedrosa, P Videm, T Lueneburg, S Kuß, H Lahm, M Dreßen, M Krane, C Schmidt, B A Grüning, N Voigt, K Streckfuss-Bömeke, R Gilsbach

Journal: Nature communications

PubMed ID: 41526351

Doi: 10.1038/s41467-025-67220-7

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Functional and Mechanistic Investigation of a Distinct DUF6895 Family Epimerase Involved in Lasso Peptide Modification

Authors: Menghan Shi, Yuwei Duan, Shao-Yang Hou, Liangxu Xie, Weifeng Sun, Liubin Feng, Youming Zhang, Xiaoying Bian, and Guannan Zhong

Journal: ACS Catalysis

Doi: 10.1021/acscatal.5c08590

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Screening for novel variable domains of the heavy chains of heavy-chain antibodies targeting different epitopes of thrombomodulin and Luminex fluorescence immunoassay for soluble thrombomodulin

Authors: Congcong Jia, Min Zhu, Yuelan He, Meixiang Yu, Xinyi Xia, Weiwei Ji, Xiang Cao, Jianzhong Lu, Hai Zhang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41314569

Doi: 10.1016/j.ijbiomac.2025.149289

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Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

Authors: Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang, Chen Lou, Sisi Li, Mingde Lin, Xin Li, Wenchao Xu, Jiaming Zhou, Peiran Hu, Zhendong Yao, Yuan Yuan, Jianzhong Sheng, Chen Zhang, Wei Yang, Youjiang Li, Hefeng Huang

Journal: EMBO Molecular Medicine

PubMed ID: 41618099

Doi: 10.1038/s44321-026-00374-z

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The visual system of the longest-living vertebrate, the Greenland shark

Authors: Lily G Fogg, Emily Tom, Maxime Policarpo, William Cho, Fangyuan Gao, Doreen Hii, Aaron E Fawcett, Nicolas Boileau, Amalie Bech-Poulsen, Kirstine F Steffensen, Cherlyn J Ng, Peter G Bushnell, John Fleng Steffensen, Richard Brill, Walter Salzburger, Dorota Skowronska-Krawczyk

Journal: Nature Communications

PubMed ID: 41491153

Doi: 10.1038/s41467-025-67429-6

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Restoration of ovarian endocrine function with encapsulated immune-isolated human ovarian xenograft in ovariectomized mice

Authors: Margaret A Brunette, Monica A Rionda, Delaney Sinko, Jordan H Machlin, Gabrielle M Blevins, Marisa Leo, Ansen Tan, Bipasha Ray, Marilia Cascalho, Vasantha Padmanabhan, Ariella Shikanov

Journal: SCIENCE ADVANCES

PubMed ID: 41477848

Doi: 10.1126/sciadv.adx6348

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Safeguarding genome integrity: Polo-like kinase Cdc5 and phosphatase Cdc14 orchestrate Topoisomerase II-mediated catenane resolution in mitosis

Authors: Lucia F Massari, Alice Finardi, Clara Visintin, Erika Calabrese, Ambra Dondi, Rosella Visintin

Journal: Nucleic Acids Research

PubMed ID: 41533572

Doi: 10.1093/nar/gkaf1509

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The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

Authors: Hongcheng Cheng, Yapeng Su, Xiaoli Pan, Yue Xu, Ermei Xie, Jing Du, Daniel G Chen, Xiaomeng Dai, Raphael Gottardo, Philip D Greenberg, Guideng Li

Journal: Nature

PubMed ID: 41535474

Doi: 10.1038/s41586-025-09926-8