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Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

Metabolic Hijacking by Engineered Probiotics Reprograms Tumor Metabolism and Immune Microenvironment for Self-Reinforcing Photodynamic Immunotherapy

Authors: Shurong Qin, Qi Wang, Zhuangwei Zhang, Junhui Gu, Guanzhong He, Fei Zeng, Ruiyue Chen, Bangshun He, Yuzhen Wang, Meng Wang, Yujun Song

Journal: Journal of the American Chemical Society

PubMed ID: 41059938

Doi: 10.1021/jacs.5c10242

Products & Services: Recombinant Proteins

Protein M fusion proteins and uses

Authors: Jay Dela Cruz , Moreno Valley , CA

Journal: U.S. Patent

Doi: US11401309B2

Products & Services: Gene Synthesis Plasmid DNA Preparation Catalog Antibody Codon Optimization

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Authors: Man Wang, Ziyu Zhang, Xiaohan Wang, Liyan Zhang, Xiangyan Chen, Nianci Li, Qiuhan Sun, Yicheng Lu, Zuhong He, Hongbo Yang, Fangzhi Tan, Jieyu Qi, Renjie Chai

Journal: Nature Communications

PubMed ID: 40968144

Doi: 10.1038/s41467-025-63613-w.

Products & Services: Proteins, Expression, Isolation and Analysis

Multifunctional NAC transcription factor SlJA2L integrates the ethylene pathway to orchestrate thermotolerance and fruit ripening in tomato

Authors: Yunfei Liang, Fang Ma, Shudi Huang, Chao Ma, Hongyan Shi, Fanyi Meng, Yinglu Chen, Han Dong, Rugang Chen, Xiangqiang Zhan

Journal: New Phytologist

PubMed ID: 40963426

Doi: 10.1111/nph.70571

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Multilevel regulation of c-di-GMP biosynthesis by cAMPsignalingincreasesShigellasonneifitnessand pathogenicity in response to bile salts

Authors: Mingfang Wang, Jia Zeng, Binbin Cui, Guangliang Wu, Xiayu Chen, Yikai Fu, Bing Gu, Yinyue Deng

Journal: Cell Rep

PubMed ID: 40966079

Doi: 10.1016/j.celrep.2025.116306

Products & Services: Proteins, Expression, Isolation and Analysis

OsEHD1 and OsEHD2, two EH domain proteins targeted by E3 ubiquitin ligase OsBBI1, negatively modulate rice immunity against blast and bacterial blight diseases

Authors: Yan Bi, Yuqing Yan, Hui Wang, Leeza Tariq, Jiamu Wang, Dayong Li, Yayun Yang, Fengming Song

Journal: Crop Journal

Doi: doi.org/10.1016/j.cj.2025.09.003

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Machine learning-based analysis of the impact of 5′ untranslated region on protein expression

Authors: Linfeng Wang, Sujia Liu, Jia-Xin Huang, Haifeng Zhu, Shuyu Li, Yannan Li, Sen Chen, Jianying Han, Yin Zhu, Jiahao Wu, Wentao Liao, Hongmei Zhang, Haiyan Zeng, Shaoting Li, Shuping Zhao, Bingwei Wang, Jiaqi Lin, Ji Zeng

Journal: Nucleic Acids Research

PubMed ID: 40923765

Doi: 10.1093/nar/gkaf861

Products & Services: Gene Synthesis

Peptide codes for organ-selective mRNA delivery

Authors: Tie Chang, Yifan Zheng, Mingrui Jiang, Siqi Jia, Jianbo Bai, Zhi Zheng, Shixin Li, Jia Guo, Yue Wang, Yiting Wang, Haixia Liu, Jianlin Liu, Liangyu Ni, Xingdi Cheng, Shuai Liu, Huijuan Zhang, Wei Pi, Feng Lin, Shiyi Liu, Weijian Wang, Guannan Wang, Leyun Wang, Lei Miao, Xueguang Lu, Ziqing Deng, Bing Bai, Zhao Qin, Huajian Gao, Yue Shao

Journal: Nature materials

PubMed ID: 40890497

Doi: 10.1038/s41563-025-02331-6

Products & Services: GenCrispr Cas9 Genome Editing

Amplifying antigen-induced cellular responses with proximity labelling

Authors: Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao, Shuo Han

Journal: Nature

PubMed ID: 40931066

Doi: 10.1038/s41586-025-09518-6. Online ahead of print.

Products & Services: Peptide Synthesis

OsSTK-mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defense in Rice

Authors: Jitao Hu, Linying Li, Yao Zhao, Xueying Zhang, Hua Wang, Junmin Wang, Peng Sun, Li Jiang, Jingqi Wang, Lili Chen, Zhongjing Zhou, Jiaoyu Wang, Keke Yi, Yuqing He, Gaojie Hong

Journal: Plant Biotechnology Journal

PubMed ID: 40927945

Doi: 10.1111/pbi.70358

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Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles

Authors: An Lao, Weiqi Li, Yiting Sun, Yuting Cao, Yu Zhuang, Jianyong Wu, Dejian Li, Kaili Lin, Jing Mao, Jiaqiang Liu

Journal: Trends in biotechnology

PubMed ID: 40925799

Doi: 10.1016/j.tibtech.2025.07.025

Products & Services: Proteins, Expression, Isolation and Analysis

A reproducible hybrid membrane for in situ analysis of cell secretions with a wide size range

Authors: Zixuan Chen, Yafeng Wu, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.110917

Products & Services: Recombinant Proteins

De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Authors: Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Tao Qian, Bang-Ce Ye, Bin-Cheng Yin

Journal: Nat Commun

PubMed ID: 41006213

Doi: 10.1038/s41467-025-63166-y

Products & Services: Gene Synthesis

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects Against In Vivo Infection via the Induction of Broad-Spectrum PRRSV Neutralization

Authors: Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A Hiscox, James P Stewart, Yani Sun, Qin Zhao

Journal: Advanced Science

PubMed ID: 40919718

Doi: 10.1002/advs.202508875

Products & Services: Molecular Biology Reagents

Planthopper protein Nlsp5 is essential for salivary sheath formation and acts as a HAMP inducing plant resistance to insects

Authors: Liangxuan Qi, Jing Li, Han Wang, Shuai Li, Lei Yang, Jichao Fang, Rui Ji

Journal: Plant Biotechnology Journal

PubMed ID: 40546084

Doi: DOI10.1111/pbi.70223

Products & Services: Polyclonal Antibody Services

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

Authors: Bin Liu, Yansi Xian, Tao Shen, Yu Ben, Wenshu Wu, Yong Shi, Xueying An, Rui Peng, Wentian Gao, Wang Gong, Xiang Chen, Baosheng Guo, Qing Jiang

Journal: Journal of extracellular vesicles

PubMed ID: 40919882

Doi: 10.1002/jev2.70162

Products & Services: Proteins, Expression, Isolation and Analysis

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

Journal: Nature Communications

PubMed ID: 40813592

Doi: doi.org/10.1038/s41467-025-63101-1

Products & Services: Peptide Synthesis

Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases

Authors: Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Journal: Biomolecules

PubMed ID: 40867598

Doi: 10.3390/biom15081153

Products & Services: Gene Synthesis

Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma

Authors: Shi-Man Zhang, Xiao-Kang Jin, Hong Chen, Yu-Zhang Wang, Jun-Long Liang, Jun Feng, Wei-Hai Chen, Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 40757917

Doi: 10.1002/adma.202508457

Products & Services: Catalog Peptides

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress

Authors: Hui Guan, Liqi Huang, Yu Liu, Enyi Zhu, Lefeng Chen, Weijie Li, Haiqi Wu, Xiaoying Zhang, Rencai Qin, Jingpeng Zheng, Yingqian Mo, Ming Zhong, Bihua Xu, Xiaoyan Dai, Qi Wei, Yunwei Chen, Qingwen Wang, Zhihua Zheng, Kongyang Ma, Chun Tang

Journal: Journal of Inflammation Research

PubMed ID: 106070

Products & Services: Endotoxin Detection & Removal System

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

Authors: Zeguang Wu, Jinhong Shi, Qiezhong Lamao, Yuanyuan Qiu, Jinxin Yang, Yang Liu, Feifei Liang, Xue Sun, Wei Tang, Changya Chen, Qingming Yang, Chunmeng Wang, Zhifang Li, Haixia Zhang, Zhonghan Yang, Yunyi Zhang, Yuting Yi, Xufen Zheng, Yu Sun, Kuiying Ma, Lingling Yu, Huihui Yang, Zhaoxuan Wang, Wenjuan Zheng, Ling Yang, Zhixuan Zhang, Yongjian Zhang, Zhiqiang Wu, Yao Wang, Catherine C L Wong, Ming Jin, Pengfei Yuan, Weidong Han, Wensheng Wei

Journal: Cell

PubMed ID: 40845838

Doi: doi.org/10.1016/j.cell.2025.07.046

Products & Services: Synthetic sgRNA and crRNA Service

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection

Authors: Yannan Yin, Jinkai Zang, Huichun Shi, Zhuang Wang, Linlin Kuang, Shuxia Wang, Haikun Wang, Ning Li, Xiaozhen Liang, Zhong Huang

Journal: Vaccines

PubMed ID: 40872916

Products & Services: Gene Synthesis

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales

Authors: Chao Sun, Hongchao Li, Yijing Liu, Jinxing Liu, Ronghong Liang, Caixia Gao

Journal: CELL

PubMed ID: 40763736

Doi: 10.1016/j.cell.2025.07.011

Products & Services: Gene Synthesis

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-DietInduced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Authors: Shuai Wang, Shuting Liu, Ting He, Huanming Shen, Chunli Mo, Yu Zhu, Wenlo, Weihua Li, Jian Zhang

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 40810347

Doi: doi.org/10.1021/acs.jafc.5c02577

Products & Services: Catalog Antibody

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

Journal: Nature Communications

PubMed ID: 40790299

Doi: doi.org/10.1038/s41467-025-62870-z

Products & Services: Gene Synthesis

Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy

Authors: Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng

Journal: Advanced Science

PubMed ID: 40874418

Doi: 10.1002/advs.202511144

Products & Services: Proteins, Expression, Isolation and Analysis

Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration

Authors: An Lao, Yiting Sun, Weiqi Li, Yu Zhuang, Ziyang Liu, Chenci Xu, Xiangbing Wu, Linhu Ge, Kaili Lin, Jianyong Wu, Jing Mao, Jiaqiang Liu

Journal: Biomaterials

PubMed ID: 40916241

Doi: 10.1016/j.biomaterials.2025.123656

Products & Services: Proteins, Expression, Isolation and Analysis

Aligned Electrospun Fibers Inducing Cell and Nuclear Morphology Remodeling via Ras-Associated Protein 1/Yes-Associated Protein Signaling Enhances Bone Regeneration

Authors: Shengjie Jiang, Jialiang Zhou, Cancan Zhao, Liyun Wang, Zeyu Fu, Mazaher Gholipourmalekabadi, Xudong Wang, Changyong Yuan, Kaili Lin

Journal: Advanced Fiber Materials

Doi: 10.1007/s42765-025-00596-9

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In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Authors: Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruihan Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Journal: Nature Chemical Biology

PubMed ID: 40775047

Doi: 10.1038/s41589-025-01993-2

Products & Services: Proteins, Expression, Isolation and Analysis

FlaB-expressing bacterial uter membrane vesicles vaccine mediating anti-tumor immune response via promoting DCs activation and lymph nodes-homing

Authors: Kaiwei Wang, Chang Xu, Minming Chen, Yifan Yan, Nanhui Liu, Changhao Zhao, Bo Liu, Yanbin Liu, Jianjiang Chen, Xiaoliang Ding, Yicong Bian, Lin Song, Xuyu Bian, Yumin Wu, Liyan Miao, Zhuang Liu

Journal: Nano Research

PubMed ID: 40817136

Doi: 10.26599/NR.2025.94907612

Products & Services: Proteins, Expression, Isolation and Analysis

Lumpy skin disease virus LSDV001 protein positively regulates inflammatory response by promoting assembly of the TAK1- TAB2/3 complex

Authors: Yu-Lin Yang, Huai-Jie Jia, Meng-Yao Sun, Ai-Min Guo, Tian Xia, Hong-Bing Shu, Li-Bo Cao

Journal: MBio

PubMed ID: 40852992

Doi: 10.1128/mbio.01677-25

Products & Services: Polyclonal Antibody Services

Bioorthogonal Non-Canonical Amino Acid Tagging (BONCAT) to detect newly synthesized proteins in cells and their secretome

Authors: Elizabeth P. Anim, Justin Mezzanotte, Siwei Chu, Ursula Stochaj

Journal: PLoS One

PubMed ID: 40811457

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains

Authors: Zebin Tong, Xiangwei Wu, Hongyi Cai, Shidian Wu, Tianyi Zhang, Zhiheng Deng, Ziyu Xu, Rujing Yuan, Huasong Ai, Lei Liu, Man Pan

Journal: Nature Chemical Biology

PubMed ID: 40817136

Doi: 10.1038/s41589-025-01985-2

Products & Services: Gene Synthesis

Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice

Authors: Shunyi Lu, Jie Cao, Zhuorun Song, Fei Gong, Peng Yang, Jun Ge, Yunfei He, Zhihui Han, Guanghui Hou, Zimin Zhang, Yuqi Yang, Yun Teng, Zengli Zhang, Jun Zou, Liang Cheng, Huilin Yang

Journal: Nature Communications

PubMed ID: 40885754

Doi: doi.org/10.1038/s41467-025-63456-5

Products & Services: Proteins, Expression, Isolation and Analysis

AMPGen: an evolutionary information-reserved and diffusion-driven generative model for de novo design of antimicrobial peptides

Authors: Shuwen Jin, Zihan Zeng, Xiyan Xiong, Baicheng Huang, Li Tang, Hongsheng Wang, Xiao Ma, Xiaochun Tang, Guoqing Shao, Xingxu Huang, Feng Lin

Journal: Communications Biology

PubMed ID: 40447738

Doi: 10.1038/s42003-025-08282-7

Products & Services: Peptide Synthesis

A Molecular Mechanism for the Reduction of the Cu Site in Lytic Polysaccharide Monooxygenases by Phenol Reductants

Authors: Langxing Liao, Jian Kuang, Peng Wu, Xianhang Sang, Heng Yin, Changlin Ti, Kingwang Zhang, Wei Peng, Lu Yu, Binju Wang

Journal: JACS Au

Doi: 10.1021/jacsau.5c00562

Products & Services: Gene Synthesis

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Journal: Journal of the American Chemical Society

PubMed ID: 40774922

Doi: doi.org/10.1021/jacs.5c08814

Products & Services: Gene Synthesis

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens

Journal: NATURE CELL BIOLOGY

PubMed ID: 40715440

Doi: 10.1038/s41556-025-01712-y

Products & Services: Gene Synthesis

Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants

Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji

Journal: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

PubMed ID: 40543628

Doi: 10.1016/j.ibmb.2025.104351

Products & Services: Polyclonal Antibody Services

Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou

Journal: Communications Biology

PubMed ID: 40783594

Doi: 10.1038/s42003-025-08607-6.

Products & Services: Proteins, Expression, Isolation and Analysis

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin.

Authors: Jing-Xiao Wang, Xiao-Yu Xu, Hong-Ke Dong, Yi-Ming Wang, Min Dai, Bing Zhou, Yue-Hua Li, Guo-Qing Zhu, Xiao-Qing Xiong

Journal: Journal of Extracellular Vesicles

PubMed ID: 40767027

Doi: 10.1002/jev2.70146.

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Lung metastasis and recurrence is mitigated by CARmacrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Authors: Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang

Journal: Nature Communications

PubMed ID: 40759657

Doi: 10.1038/s41467-025-62506-2

Products & Services: Custom DNA/RNA Oligos

A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo

Authors: Wei Zhang, Lizhen Yuan, Rui Liu, Yanbo Jing, Shijun Lin, Hao Fang, Yuxuan Li, Xiaohui Zhang, Jun Dai, Tao Liu, Fan Xia, Xiaoding Lou

Journal: J Am Chem Soc

PubMed ID: 40717291

Doi: 10.1021/jacs.5c07041

Products & Services: Recombinant Proteins

Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

Authors: Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen, Jie Cao, Zimin Zhang, Jun Ge, Huilin Yang, Liang Cheng

Journal: National Science Review

Doi: 10.1093/nsr/nwaf365

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii

Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang

Journal: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PubMed ID: 40616507

Doi: doi.org/10.1021/acs.jafc.5c03402

Products & Services: Gene Synthesis

CD19-ReTARGTPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies

Authors: Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers

PubMed ID: 40723184

Products & Services: Gene Synthesis

An integrated electrochemical nanodevice for single-cell MiRNA-155 detection and drug evaluation

Authors: Zhuo Li , Zhaohan Wang , Jun Chen , Yafeng Wu

Journal: BIOSENSORS & BIOELECTRONICS

PubMed ID: 40695112

Doi: 10.1016/j.bios.2025.117804

Products & Services: PCR Cloning and Subcloning

Deficiency of IFNAR1 Increases the Production of Influenza Vaccine Viruses in MDCK Cells

Authors: Qi Wang, Tuanjie Chen, Mengru Feng, Mei Zheng, Feixia Gao, Chenchen Qiu, Jian Luo, Xiuling Li

Journal: Viruses-Basel

Doi: 10.3390/v17081097

Products & Services: Nucleic Acid Purification & Analysis

Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles

Authors: Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin

Journal: Interdisciplinary Materials

Doi: doi.org/10.1002/idm2.70000

Products & Services: Proteins, Expression, Isolation and Analysis

BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

Authors: Chen Guo, Zhilin Long, Peng Lin, Yinan Shen, Yiye Zhong, Jingjing Qian, Jichuan Yu, Weixi Zhao, Fuyi Liu, Yiling Ma, Jian Zheng, Jiayao Yang, Shuai Zhao, Xiaojuan Ran, Zhen Xia, Congying Wu, Yujia Cai, Chen Wang, Qi Xie

Journal: Cell Reports Medicine

PubMed ID: 40744020

Doi: 10.1016/j.xcrm.2025.102258

Products & Services: GenCrispr Cas9 Genome Editing

ZEB2 is a master switch controlling the tumor-associated macrophage program

Authors: Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher-Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan, Kiara Freitag, Ido Yofe, Vladimir Yutkin, Pierre Boyeau, Can Ergen, Justin Hong, Kfir Mazuz, Yuxiao Liu, Kangming Chen, Rony Dahan, Marcin Kortylewski, Nir Yosef, Assaf Weiner, Ido Amit

Journal: Cancer Cell

PubMed ID: 40215981

Doi: 10.1016/j.ccell.2025.03.021

Products & Services: Synthetic sgRNA and crRNA Service

A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao

Journal: Advanced Science

PubMed ID: 40685690

Doi: 10.1002/advs.202509419

Products & Services: Proteins, Expression, Isolation and Analysis

Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma

Authors: Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue

Journal: ACS Nano

PubMed ID: 40698543

Doi: 10.1021/acsnano.5c08928

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Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Proteins, Expression, Isolation and Analysis

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: MICROCHEMICAL JOURNAL

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

β-catenin functions as a molecular adapter for disordered cBAF interactions

Authors: Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges

Journal: Molecular Cell

PubMed ID: 40695292

Products & Services: Recombinant Proteins

Formation and centromere inactivation of fusion chromosomes in two allotetraploid species from the Saccharum complex

Authors: Zehuai Yu, Yongji Huang, Xikai Yu, Zuhu Deng, Jin Chai, Jiarui Liu, Zhiyun Gong, Wei Yao, Jisen Zhang, Muqing Zhang, Fan Yu, Jiming Jiang

Journal: NEW PHYTOLOGIST

PubMed ID: 40726300

Doi: 10.1111/nph.70369

Products & Services: Oligo pool

Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization

Authors: Di Wang, Linzhu Zhang, Jihu Nie, Nailin Yang, Shumin Sun, Chunjie Wang, Zifan Pei, Fei Gong, Xingwei Sun, Yong Jin, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 40644662

Doi: 10.1021/jacs.5c06039

Therapeutic circRNA aptamer alleviates PKR-associated osteoarthritis

Authors: Si-Kun Guo, Jinlong Suo, Youkui Huang, Xubin Yin, Jinghui Wang, Ling Li, Shaokun Sun, Weiguo Zou, Ling-Ling Chen

Journal: Science Bulletin

PubMed ID: 40021383

Doi: 10.1016/j.scib.2025.02.027

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

Journal: nature COMMUNICATION

PubMed ID: 40681508

Doi: 10.1038/s41467-025-62023-2

Products & Services: Protein A Resin

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis

Authors: Weixia Liu , Guodi Wu , Jing Wang , Shanshan Wu , Zhi Chen

Journal: Molecular Medicine Reports

PubMed ID: 40376993

Doi: 10.3892/mmr.2025.13567

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Authors: Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun, Chunjie Wang, Duo Wang, Jihu Nie, Juan Qin, Lei Zhang, Liang Cheng, Haidong Zhu

Journal: Bioactive Materials

PubMed ID: 40792115

Doi: 10.1016/j.bioactmat.2025.07.040

Products & Services: Proteins, Expression, Isolation and Analysis

Identifying and characterizing a missing peroxin-PEX8-in Arabidopsis thaliana

Authors: Gabrielle C Buck, Ashley D Weeks, Niamh E Ordner, Bonnie Bartel

Journal: PLANT CELL

PubMed ID: 40577590

Doi: 10.1093/plcell/koaf166

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Chromosome-specific oligo-painting provides insights into the cytogenetic basis of karyotypic stasis in paleo-allotetraploid Cucurbita

Authors: Qinzheng Zhao, Yulin Bai, Yuhui Wang, Chunyan Cheng, Xiaqing Yu, Qunfeng Lou, Jinfeng Chen

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhaf179

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High-fidelity DNA polymerase for DNA-based digital Information Storage

Authors: Xutong Liu, Kai Wen, Enyang Yu, Qixuan Zhao, Haoran Fu, Jingxuan Zhu, Haobo Han, Quanshun Li

Journal: Small Methods

PubMed ID: 40665906

Doi: 10.1002/smtd.202500817

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An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment

Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen

Journal: Acta Biomaterialia

PubMed ID: 40409996

Doi: 10.1016/j.actbio.2025.05.040

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AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

Authors: Keyu Kong, Li Liu, Renfang Zhang, Yongyun Chang, Yueming Shao, Chen Zhao, Hua Qiao, Minghao Jin, Xuzhuo Chen, Wentao Shi, Xinru Wu, Wenxuan Fan, Yuehao Hu, Kewei Rong, Pu Zhang, Baixing Li, Jingwei Zhang, Peixiang Ma, Xiaoling Zhang, Huiwu Li, Zanjing Zhai

Journal: Bone Research

PubMed ID: 40461512

Doi: 10.1038/s41413-025-00431-2

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Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling

PubMed ID: 40514668

Doi: 10.1186/s12964-025-02289-7

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Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong

Journal: Cellular & Molecular Immunology

PubMed ID: 40500403

Doi: 10.1038/s41423-025-01305-7

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Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus

Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song

Journal: International Journal of Biological Macromolecules

PubMed ID: 40543771

Doi: doi.org/10.1016/j.ijbiomac.2025.145363

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LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

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Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

Authors: Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos-Rodriguez, Katherine H. Griffin, Gabriella C. Bond, J. Kent Leach

Journal: ADVANCED FUNCTIONAL MATERIALS

Doi: 10.1002/adfm.202311017

Products & Services: Peptide Synthesis

Antimicrobial and Potent Anti- Biofilm Properties of Rationally Designed α- Helix Antimicrobial Peptides

Authors: Motasim Ismael, Khayeli Juliah, Madivoli Edwin

Journal: Journal of Peptide Science

PubMed ID: 40326595

Doi: 10.1002/psc.70027

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Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

Authors: Ding Qiu, Shuishen Zhang, Chanyan Huang, Xinying Wang, Jianping Deng, Haiyang Sun, Bingbing Feng, Ying Tan, Kaile Ji, Shaoting Xu, Xiaoqi Ye, Chao Cheng, Shigeru Kakuta, Yoshiyuki Adachi, Yoichiro Iwakura, Shuai Wang, Shaowei Dong, Ce Tang

Journal: Immunity

PubMed ID: 40494347

Doi: 10.1016/j.immuni.2025.05.007

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Collective Biosynthesis of Plant Spirooxindole Alkaloids through Enzyme Discovery and Engineering

Authors: Danni Chu, Hongkui Wang, Zhiwen Nie, Kang-Li Li, Jiaqing Cao, Meijing Yang, Qin Yin, Yang Gu, Yindi Jiang

Journal: Journal of the American Chemical Society

PubMed ID: 40504680

Doi: 10.1021/jacs.5c02990

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Control of seed-to-seedling transition by an upstream open reading frame in ABSCISIC ACID DEFICIENT2

Authors: Zhen Wang , Xiaofan Zhang ， Can Zhou , Xiaofeng Cao

Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PubMed ID: 40478869

Doi: 10.1073/pnas.2502155122

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Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15

Authors: Manashi Sonowal, Gihan Ketawala, Nirupa Nagaratnam, Dhenugen Logeswaran, Shibom Basu, Daniele de Sanctis, Julien Orlans, Samuel L Rose, Rebecca J Jernigan, Hao Hu, Jose Domingo Meza Aguilar, Madurangi E Ranaweera, Michele A Zacks, Julian J-L Chen, Debra T Hansen, Lynn G Schrag, Raimund Fromme, Sabine Botha, Petra Fromme

Journal: PROTEIN SCIENCE

PubMed ID: 40411374

Doi: 10.1002/pro.70115

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Sodium butyrate attenuates lipid metabolism disorder via improving mitochondrial function and activating autophagy in LMH cells

Authors: Sasa Miao, Mengru Xu, Fang Liu, Xinyang Dong, Xiaoting Zou, Tao Zeng, Lizhi Lu

Journal: POULTRY SCIENCE

Doi: doi.org/10.1016/j.psj.2025.105476

Products & Services: Proteins, Expression, Isolation and Analysis

Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma

Authors: Jie Liu, Yuandong Liu, Dongmin Yin, Yang Tian

Journal: Cell chemical biology

PubMed ID: 40466640

Doi: 10.1016/j.chembiol.2025.05.002

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Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy

Authors: Chris van Ewijk, Greeshma Jain, Yari K Knelissen, Sourav Maity, Patrick C A van der Wel, Wouter H Roos

Journal: J Am Chem Soc

PubMed ID: 40505012

Doi: 10.1021/jacs.5c05571

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Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePt Dual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis

Authors: Qianglan Lu, Chengwei Ye, Wei Mao, Fei Zeng, Zhiyong Liu, Ruiyue Chen, Xiao Cheng, Yanfeng Gao, Meng Wang, Mei Liu, Shaochun Tang, Yujun Song

Journal: ACS Nano .

PubMed ID: 40532220

Doi: 10.1021/acsnano.5c04686

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NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence

Authors: Zheng Dai, Feng Liu, Miaodeng Liu, Yuqi Song, Hongyan Zhang, Cheng Zhou, Wenyu Liu, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang

Journal: Bioactive Materials

Doi: https://doi.org/10.1016/j.bioactmat.2025.06.037

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Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Authors: Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu & Haipeng Gong

Journal: Nature Machine Intelligence

Doi: doi.org/10.1038/s42256-025-01059-x

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Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

Authors: Shruthi Krishnaswamy, Shirin Akbar, Daniel S D Larsson, Yang Chen, Maria Selmer

Journal: Nature Communications

PubMed ID: 40571681

Doi: 10.1101/2024.12.14.628468

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Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

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Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

Products & Services: Proteins, Expression, Isolation and Analysis

RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

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Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

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Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

Products & Services: Proteins, Expression, Isolation and Analysis

Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

Authors: Shixian Tao, Wei He, Chuntong Li, Jiawei Liang, Zebin Tong, Zhiheng Deng, Liying Zhang, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Science China-Chemistry

Doi: 10.1007/s11426-025-2697-6

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YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

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Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N Gurzov, Olov Andersson, Sumeet Pal Singh

Journal: Nature Communication

PubMed ID: 40480975

Doi: 10.1038/s41467-025-60334-y

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Histidine-Specific Modification of Chitin-Binding protein21 via Visible Light-Mediated C–H Functionalization and Protein Ligation

Authors: Xinliang Liu, Ping Wang and Farong Ye

Journal: CCS Chemistry

Doi: 10.31635/ccschem.024.202404864

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High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Authors: Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel, Christopher P Earl, Samantha Fisher, Rhian S Holvey, Scott M Jackson, Emyr Lloyd-Evans, Carmine M Morgillo, Paul N Mortenson, Marc O'Reilly, Caroline J Richardson, Patrick Schöpf, Daniel M Tams, Helen Waller-Evans, Simon E Ward, Stuart Whibley, Pamela A Williams, Christopher N Johnson

Journal: Structure

PubMed ID: 40532704

Doi: 10.1016/j.str.2025.05.014

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An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

Authors: Liangxuan Qi, Jing Li, Shuai Li, Jing Li, Han Wang, Lei Yang, Xinyang Tan, Zhichang Zhao, Guanghua Luo, Maofeng Jing, Ary A Hoffmann, Jichao Fang, Rui Ji

Journal: Advanced Science

PubMed ID: 40167256

Doi: 10.1002/advs.202415474

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Patch-Clamp-like Micropipette Electrode with Exterior and Interior Interfaces for Simultaneous Monitoring of Extracellular and Intracellular Serotonin across Neuron

Authors: Jie Liu, Qin Zhou, Yuandong Liu,Yang Tian

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Doi: 10.1002/anie.202504408

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Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

Authors: Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun & Yun-Jia Ning

Journal: Nature Communication

Doi: 10.1038/s41467-025-61431-8

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Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Yixi Dong, Runyu Zhao, Jia Man, Jianwei Jiao, Zhaoyin Wang, Jin Jiao

Journal: Theranostics

Doi: 10.7150/thno.111583

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Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation

Authors: Zixuan Mei, Kamuran Yilamu, Weiyu Ni, Panyang Shen, Nan Pan, Huasen Chen, Yingfeng Su, Lei Guo, Qunan Sun, Zhaomei Li, Dongdong Huang, Xiangqian Fang, Shunwu Fan, Haitao Zhang, Shuying Shen

Journal: nature COMMUNICATION

PubMed ID: 40425566

Doi: 10.1038/s41467-025-60037-4

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