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Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis

Authors: Yanzi Yan, Huiyi Liang, Xingliang Liu, Lixin Liu, Yongming Chen

Journal: Biomaterials

PubMed ID: 34293700

Doi: 10.1016/j.biomaterials.2021.121027

Products & Services: DNA Sequencing

Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179

Authors: Wolfrat Bachert, Lisa Klotz, Heinrich Sticht, Ralf Enz

Journal: Neurochem Int

PubMed ID: 34333057

Doi: 10.1016/j.neuint.2021.105150

Products & Services: DNA Sequencing

Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

Authors: Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, Pernille Poulsen, Jonathan Lou S Esguerra, Lena Eliasson, Allan Vaag, Olga Göransson, Charlotte Ling

Journal: Diabetes

PubMed ID: 34315727

Doi: 10.2337/db20-0324

Products & Services: DNA Sequencing

TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway

Authors: Da-Cen Lin, Si-Yi Zheng, Zhi-Guang Zhang, Jian-Hua Luo, Zhuang-Li Zhu, Li Li, Lu-Shan Chen, Xinjian Lin, James S K Sham, Mo-Jun Lin, Rui-Xiang Zhou

Journal: Cancer Lett

PubMed ID: 34311033

Doi: 10.1016/j.canlet.2021.07.038

Products & Services: DNA Sequencing

PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis

Authors: Zili Liu, Honglin Wang, Shaoqian Wang, Jie Gao, Lei Niu

Journal: Bone Joint Res

PubMed ID: 34254815

Doi: 10.1302/2046-3758.107.BJR-2020-0200.R2

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CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening

Authors: Jianghua Liu, Jiahui Chen, Di Wu, Mingquan Huang, Jian Chen, Ruiyuan Pan, Yongning Wu, Guoliang Li

Journal: Anal Chem

PubMed ID: 34278781

Doi: 10.1021/acs.analchem.1c01163

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Dual Targeting of Endoplasmic Reticulum by Redox-Deubiquitination Regulation for Cancer Therapy

Authors: Biao Cai, Mengfei Hou, Shijun Zhang, Zhixiang Xin, Jiwei Huang, Jingxing Yang, Yueming Wang, Xingyun Cai, Shaowei Xie, Chunfu Zhang, Yiran Huang

Journal: Int J Nanomedicine

PubMed ID: 34354353

Doi: 10.2147/IJN.S321612

Products & Services: Proteins, Expression, Isolation and Analysis

Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway

Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin, Xiaohua Liu

Journal: Reprod Biol Endocrinol

PubMed ID: 34266426

Doi: 10.1186/s12958-021-00796-z

Products & Services: Proteins, Expression, Isolation and Analysis

Latent tuberculosis co-infection is associated with heightened levels of humoral, cytokine and acute phase responses in seropositive SARS-CoV-2 infection

Authors: Anuradha Rajamanickam, Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Arul Nancy, Nandhini Selvaraj, Kushiyasri Karunanithi, Saravanan Munisankar, Shrinivasa Bm, Rachel Mariam Renji, T C Ambu, Vijayalakshmi Venkataramani, Subash Babu

Journal: J Infect

PubMed ID: 34329676

Doi: 10.1016/j.jinf.2021.07.029

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a mammalian sperm cation channel complex

Authors: Shiyi Lin, Meng Ke, Yuqi Zhang, Zhen Yan, Jianping Wu

Journal: Nature

PubMed ID: 34225353

Doi: 10.1038/s41586-021-03742-6

Products & Services: Proteins, Expression, Isolation and Analysis

Epitope-Paratope Interaction of a Neutralizing Human Anti-Hepatitis B Virus PreS1 Antibody That Recognizes the Receptor-Binding Motif

Authors: Jisu Hong, Youngjin Choi, Yoonjoo Choi, Jiwoo Lee, Hyo Jeong Hong

Journal: Vaccines (Basel)

PubMed ID: 34358170

Doi: 10.3390/vaccines9070754

Products & Services: Proteins, Expression, Isolation and Analysis

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Authors: Gábor Wittmann, Malcolm J Low, Ronald M Lechan

Journal: Mol Metab

PubMed ID: 34329773

Doi: 10.1016/j.molmet.2021.101312

Products & Services: Plasmid DNA Preparation

Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation

Authors: Jialiang Shao, Tiezhu Shi, Hua Yu, Yufeng Ding, Liping Li, Xiang Wang, Xiongjun Wang

Journal: EMBO J

PubMed ID: 34269483

Doi: 10.15252/embj.2020107480

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Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia

Authors: Michael A Kiebish, Poornima Tekumalla, Shobha Ravipaty, Albert Dobi, Shiv Srivastava, Wenfang Wu, Saurabh Patil, Tracey Friss, Allison Klotz, Alagarsamy Srinivasan, Jennifer Cullen, Inger L Rosner, Amina Ali, Sandra Laszlo, Michele Petrovic, Neil Fleshner, Jeonifer Garren, Greg Miller, Nischal Mahaveer Chand, Leonardo O Rodrigues, Elder Granger, Mark D Kellogg, Shen Luan, Eleftherios Diamandis, Viatcheslav R Akmaev, Rangaprasad Sarangarajan, Chas Bountra, Stephen J Freedland, David G McLeod, Niven R Narain

Journal: Sci Rep

PubMed ID: 34302010

Doi: 10.1038/s41598-021-94438-4

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Hepta-Histidine Inhibits Tau Aggregation

Authors: Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazawa

Journal: ACS Chem Neurosci

PubMed ID: 34319089

Doi: 10.1021/acschemneuro.1c00164

Products & Services: Peptide Library Services

The importance of vitellogenin receptors in the oviposition of the pond wolf spider, Pardosa pseudoannulata

Authors: Zhi-Ming Yang, Tian-Yu Lu, Yong Wu, Na Yu, Guang-Ming Xu, Qian-Qian Han, Ze-Wen Liu

Journal: Insect Sci

PubMed ID: 34237799

Doi: 10.1111/1744-7917.12933

Products & Services: PCR and Cloning

High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins

Authors: Josefien W Hommes, Rachel M Kratofil, Sigrid Wahlen, Carla J C de Haas, Reeni B Hildebrand, G Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J A Korporaal, Bas G J Surewaard

Journal: Sci Rep

PubMed ID: 34321507

Doi: 10.1038/s41598-021-94651-1

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An octopamine receptor confers selective toxicity of amitraz on honeybees and mites

Authors: Lei Guo, Xin-Yu Fan, Xiaomu Qiao, Craig Montell, Jia Huang

Journal: Elife

PubMed ID: 34263722

Doi: 10.7554/eLife.68268

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Can commercial automated immunoassays be utilized to predict neutralizing antibodies after SARS-CoV-2 infection? A comparative study between three different assays

Authors: Ahmed Ismail, Farah M Shurrab, Hadeel T Al-Jighefee, Duaa W Al-Sadeq, Hamda Qotba, Ibrahim Abdu Al-Shaar, Hadi M Yassine, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Front Biosci (Landmark Ed)

PubMed ID: 34340267

Doi: 10.52586/4934

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Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI

Authors: Alireza Nomani, Geng Li, Siavash Yousefi, Shawn Wu, Obeid M Malekshah, Shahryar K Nikkhoi, Mehrdad Pourfathi, Rahim Rizi, Arash Hatefi

Journal: J Control Release

PubMed ID: 34284047

Doi: 10.1016/j.jconrel.2021.07.022

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Assays for studying normal suppressive ERAD-associated retrotranslocation pathways in yeast

Authors: Satarupa Bhaduri, Sonya E Neal

Journal: STAR Protoc

PubMed ID: 34278330

Doi: 10.1016/j.xpro.2021.100640

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Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry

Authors: Alessandra Luchini, Samantha Micciulla, Giacomo Corucci, Krishna Chaithanya Batchu, Andreas Santamaria, Valerie Laux, Tamim Darwish, Robert A Russell, Michel Thepaut, Isabelle Bally, Franck Fieschi, Giovanna Fragneto

Journal: Sci Rep

PubMed ID: 34290262

Doi: 10.1038/s41598-021-93996-x

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AstraZeneca (AZD1222) Covid 19 vaccine-associated adverse drug event: a case report

Authors: Capassoni Marco, Ketabchi Sheyda, Cassisa Angelo, Caramelli Riccardo, Molinu Antonietta Anna, Galluccio Felice, Guiducci Serena

Journal: J Med Virol

PubMed ID: 34214206

Doi: 10.1002/jmv.27175

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miR-29c-3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

Authors: Ruili Wang, Jie Yao, Fuhua Gong, Songsheng Chen, Ya He, Chunting Hu, Chen Li

Journal: Genes Cells

PubMed ID: 34086379

Doi: 10.1111/gtc.12877

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Development of a Bioluminescent Human Osteosarcoma Model in Humanized NSG Mice: A Pilot Study

Authors: Yunmi Ko, Yeon Ho Jeong, Jin-Hee Seo, Jun Ah Lee

Journal: In Vivo

PubMed ID: 34182491

Doi: 10.21873/invivo.12485

Products & Services: Proteins, Expression, Isolation and Analysis

Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage

Authors: Ruming Deng, Wenjie Wang, Xiang Xu, Jiasheng Ding, Jiahe Wang, Siyuan Yang, Haiying Li, Haitao Shen, Xiang Li, Gang Chen

Journal: Mol Neurobiol

PubMed ID: 34232477

Doi: 10.1007/s12035-021-02468-w

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PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging

Authors: Anna S Kirstein, Stephanie Kehr, Michèle Nebe, Martha Hanschkow, Lisa A G Barth, Judith Lorenz, Melanie Penke, Jana Breitfeld, Diana Le Duc, Kathrin Landgraf, Antje Körner, Peter Kovacs, Peter F Stadler, Wieland Kiess, Antje Garten

Journal: J Biol Chem

PubMed ID: 34273354

Doi: 10.1016/j.jbc.2021.100968

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Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity

Authors: Frauke Muecksch, Helen Wise, Kate Templeton, Becky Batchelor, Maria Squires, Kirsty McCance, Lisa Jarvis, Kristen Malloy, Elizabeth Furrie, Claire Richardson, Jacqueline MacGuire, Ian Godber, Alana Burns, Sally Mavin, Fengwen Zhang, Fabian Schmidt, Paul Bieniasz, Sara Jenks, Theodora Hatziioannou

Journal: medrxiv

PubMed ID: 34268524

Doi: 10.1101/2021.07.02.21259939

Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction

Authors: K N Westlund, M A Montera, A E Goins, S R A Alles, M Afaghpour-Becklund, R Bartel, R Durvasula, A Kunamneni

Journal: Neurobiol Pain

PubMed ID: 34458647

Doi: 10.1016/j.ynpai.2021.100067

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The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response

Authors: Bo Liu, Jiancheng Huang, Amina Ashraf, Oindrila Rahaman, Jing Lou, Ling Wang, Peiliang Cai, Jinping Wen, Shoaib Anwaar, Xiaoli Liu, Hai Ni, Dipyaman Ganguly, Jijun Zhao, Cliff Y Yang

Journal: Nat Commun

PubMed ID: 34215755

Doi: 10.1038/s41467-021-24352-w

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Genome-wide identification of candidate aquaporins involved in water accumulation of pomegranate outer seed coat

Authors: Jianjian Liu, Gaihua Qin, Chunyan Liu, Xiuli Liu, Jie Zhou, Jiyu Li, Bingxin Lu, Jianrong Zhao

Journal: PeerJ

PubMed ID: 34316414

Doi: 10.7717/peerj.11810

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Screening New Xylanase Biocatalysts from the Mangrove Soil Diversity

Authors: Corinne Ivaldi, Mariane Daou, Laurent Vallon, Alexandra Bisotto, Mireille Haon, Sona Garajova, Emmanuel Bertrand, Craig B Faulds, Giuliano Sciara, Adrien Jacotot, Cyril Marchand, Mylène Hugoni, Harivony Rakotoarivonina, Marie-Noëlle Rosso, Caroline Rémond, Patricia Luis, Eric Record

Journal: Microorganisms

PubMed ID: 34361919

Doi: 10.3390/microorganisms9071484

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Tobacco BY2 cells expressing recombinant cardosin B as an alternative for production of active milk clotting enzymes

Authors: André Folgado, Rita Abranches

Journal: Sci Rep

PubMed ID: 34262119

Doi: 10.1038/s41598-021-93882-6

Products & Services: Mammalian Expression

Heat-dependent opening of TRPV1 in the presence of capsaicin

Authors: Do Hoon Kwon, Feng Zhang, Yang Suo, Jonathan Bouvette, Mario J Borgnia, Seok-Yong Lee

Journal: Nat Struct Mol Biol

PubMed ID: 34239123

Doi: 10.1038/s41594-021-00616-3

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The upstream 5' splice site remains associated to the transcription machinery during intron synthesis

Authors: Yodfat Leader, Galit Lev Maor, Matan Sorek, Ronna Shayevitch, Maram Hussein, Ofir Hameiri, Luna Tammer, Jonathan Zonszain, Ifat Keydar, Dror Hollander, Eran Meshorer, Gil Ast

Journal: Nat Commun

PubMed ID: 34315864

Doi: 10.1038/s41467-021-24774-6

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Low neutralizing antibody responses in WM, CLL and NHL patients after the first dose of the BNT162b2 and AZD1222 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Efstathios Kastritis, Alexandros Briasoulis, Sentiljana Gumeni, Ioannis Ntanasis-Stathopoulos, Aimilia D Sklirou, Panagiotis Malandrakis, Evangelos Eleutherakis-Papaiakovou, Magdalini Migkou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Clin Exp Med

PubMed ID: 34283338

Doi: 10.1007/s10238-021-00746-4

Overexpression of Douglas-Fir () in Induces Embryonic Programs and Embryo-like Structures in the Mutant but Not in Wild Type Plants

Authors: Mariana A Vetrici, Dmytro P Yevtushenko, Santosh Misra

Journal: Plants (Basel)

PubMed ID: 34451571

Doi: 10.3390/plants10081526

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated workflow for urinary prostate specific antigen N-glycosylation analysis using sdAb partitioning and downstream capillary electrophoresis separation

Authors: Balazs Reider, Eszter Gacsi, Hajnalka Jankovics, Ferenc Vonderviszt, Tibor Szarvas, Andras Guttman, Gabor Jarvas

Journal: Anal Chim Acta

PubMed ID: 34625256

Doi: 10.1016/j.aca.2021.338892

Products & Services: PCR Cloning and Subcloning

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

Authors: Jérémie Prévost, Jonathan Richard, Romain Gasser, Shilei Ding, Clément Fage, Sai Priya Anand, Damien Adam, Natasha Gupta Vergara, Alexandra Tauzin, Mehdi Benlarbi, Shang Yu Gong, Guillaume Goyette, Anik Privé, Sandrine Moreira, Hugues Charest, Michel Roger, Walther Mothes, Marzena Pazgier, Emmanuelle Brochiero, Guy Boivin, Cameron F Abrams, Arne Schön, Andrés Finzi

Journal: biorxiv

PubMed ID: 34268505

Doi: 10.1101/2021.07.09.451812

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

Authors: Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M Yeung, Wenchao Wang, Bengt Hallberg, Ruth H Palmer, Meredith S Irwin, Rani E George

Journal: Cell Rep

PubMed ID: 34260934

Doi: 10.1016/j.celrep.2021.109363

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LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer

Authors: Y Cheng, H-Y Xiong, Y-M Li, H-R Zuo, Y Liu, G-L Liao

Journal: Eur Rev Med Pharmacol Sci

PubMed ID: 34337714

Doi: 10.26355/eurrev_202107_26377

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Association of total and neutralizing SARS-CoV-2 spike -receptor binding domain antibodies with epidemiological and clinical characteristics after immunization with the 1 and 2 doses of the BNT162b2 vaccine

Authors: Athanasios Michos, Elizabeth-Barbara Tatsi, Filippos Filippatos, Charilaos Dellis, Dimitra Koukou, Vasiliki Efthymiou, Evangelia Kastrinelli, Aimilia Mantzou, Vasiliki Syriopoulou

Journal: Vaccine

PubMed ID: 34400017

Doi: 10.1016/j.vaccine.2021.07.067

An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function

Authors: Wei-Jye Lin, Yan Zhao, Zhe Li, Shuyu Zheng, Jin-Lin Zou, Noël A Warren, Purva Bali, Jingru Wu, Mengdan Xing, Cheng Jiang, Yamei Tang, Stephen R Salton, Xiaojing Ye

Journal: Transl Psychiatry

PubMed ID: 34238925

Doi: 10.1038/s41398-021-01489-2

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Activation of Adenosine A Receptor in Ischemic Stroke: Neuroprotection by Tetrahydroxy Stilbene Glycoside as an Agonist

Authors: Lingyu Ruan, Guanghui Li, Wenlong Zhao, Huihui Meng, Qi Zheng, Junsong Wang

Journal: Antioxidants (Basel)

PubMed ID: 34356346

Doi: 10.3390/antiox10071112

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Differential Modulation of Heat-Inducible Genes Across Diverse Genotypes and Molecular Cloning of a sHSP From Pearl Millet [ (L) R Br]

Authors: S Mukesh Sankar, C Tara Satyavathi, Sharmistha Barthakur, Sumer Pal Singh, C Bharadwaj, S L Soumya

Journal: Front Plant Sci

PubMed ID: 34335644

Doi: 10.3389/fpls.2021.659893

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Introduction of the Carotenoid Biosynthesis α-Branch Into sp PCC 6803 for Lutein Production

Authors: Martin Lehmann, Evgenia Vamvaka, Alejandro Torrado, Peter Jahns, Marcel Dann, Lea Rosenhammer, Amel Aziba, Dario Leister, Thilo Rühle

Journal: Front Plant Sci

PubMed ID: 34295345

Doi: 10.3389/fpls.2021.699424

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The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells

Authors: Moritz Bewarder, Maximilian Kiefer, Helene Will, Kathrin Olesch, Clara Moelle, Stephan Stilgenbauer, Konstantinos Christofyllakis, Dominic Kaddu-Mulindwa, Joerg Thomas Bittenbring, Natalie Fadle, Evi Regitz, Lea Kaschek, Markus Hoth, Frank Neumann, Klaus-Dieter Preuss, Michael Pfreundschuh, Lorenz Thurner

Journal: HemaSphere

PubMed ID: 34263144

Doi: 10.1097/HS9.0000000000000620

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Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study

Authors: Jessica Seeßle, Tim Waterboer, Theresa Hippchen, Julia Simon, Marietta Kirchner, Adeline Lim, Barbara Müller, Uta Merle

Journal: Clin Infect Dis

PubMed ID: 34223884

Doi: 10.1093/cid/ciab611

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Antibody Response After Initial Vaccination for SARS-CoV-2 in Patients With Amyloidosis

Authors: Efstathios Kastritis, Evangelos Terpos, Aimilia Sklirou, Foteini Theodorakakou, Despina Fotiou, Eleni-Dimitra Papanagnou, Tina Bagratuni, Nikolaos Kanellias, Maria Gavriatopoulou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: HemaSphere

PubMed ID: 34278231

Doi: 10.1097/HS9.0000000000000614

Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer

Authors: Ruocong Zhao, Yuanbin Cui, Yongfang Zheng, Shanglin Li, Jiang Lv, Qiting Wu, Youguo Long, Suna Wang, Yao Yao, Wei Wei, Jie Yang, Bin-Chao Wang, Zhenfeng Zhang, Hui Zeng, Yangqiu Li, Peng Li

Journal: Front Immunol

PubMed ID: 34326835

Doi: 10.3389/fimmu.2021.660488

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High Prevalence of Anti-PF4 Antibodies Following ChAdOx1 nCov-19 (AZD1222) Vaccination Even in the Absence of Thrombotic Events

Authors: Evangelos Terpos, Marianna Politou, Ioannis Ntanasis-Stathopoulos, Vangelis Karalis, Efrosyni Merkouri, Despina Fotiou, Maria Gavriatopoulou, Panagiotis Malandrakis, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34358129

Doi: 10.3390/vaccines9070712

Surveillance of Borrelia miyamotoi-carrying ticks and genomic analysis of isolates in Inner Mongolia, China

Authors: Kozue Sato, Dan Liu, Yunhong Cui, Xuhong Yin, Lihua Zhang, Hong Li, Tingfu Wang, Rongxin Liu, Lijing Wu, Saixia Lu, Ting Gao, Zitong Zhang, Minzhi Cao, Guodong Wang, Chunpu Li, Dacheng Yan, Norio Ohashi, Shuji Ando, Hiroki Kawabata

Journal: Parasit Vectors

PubMed ID: 34274015

Doi: 10.1186/s13071-021-04809-z

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Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process

Authors: Benjamin Petre, Mauricio P Contreras, Tolga O Bozkurt, Martin H Schattat, Jan Sklenar, Sebastian Schornack, Ahmed Abd-El-Haliem, Roger Castells-Graells, Rosa Lozano-Durán, Yasin F Dagdas, Frank L H Menke, Alexandra M E Jones, Jack H Vossen, Silke Robatzek, Sophien Kamoun, Joe Win

Journal: Plant Cell

PubMed ID: 33677602

Doi: 10.1093/plcell/koab069

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Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-κB signalling

Authors: Mei Yang, Qishan Chen, Li Mei, Guanmei Wen, Weiwei An, Xinmiao Zhou, Kaiyuan Niu, Chenxin Liu, Meixia Ren, Kun Sun, Qingzhong Xiao, Li Zhang

Journal: Br J Pharmacol

PubMed ID: 34076894

Doi: 10.1111/bph.15583

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SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses

Authors: George W Carnell, Katarzyna A Ciazynska, David A Wells, Xiaoli Xiong, Ernest T Aguinam, Stephen H McLaughlin, Donna Mallery, Soraya Ebrahimi, Lourdes Ceron-Gutierrez, Benedikt Asbach, Sebastian Einhauser, Ralf Wagner, Leo C James, Rainer Doffinger, Jonathan L Heeney, John A G Briggs

Journal: J Virol

PubMed ID: 33963055

Doi: 10.1128/JVI.00203-21

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Effective Antitumor of Orally Intestinal Targeting Penetrating Peptide-Loaded Tyroserleutide/PLGA Nanoparticles in Hepatocellular Carcinoma

Authors: Chenjun Ma, Tiantian Wei, Yingying Hua, Zhongjie Wang, Liefeng Zhang

Journal: Int J Nanomedicine

PubMed ID: 34239301

Doi: 10.2147/IJN.S315713

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P2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain

Authors: Yucui Jiang, Fan Ye, Ying Du, Yingxin Zong, Zongxiang Tang

Journal: J Inflamm Res

PubMed ID: 34239315

Doi: 10.2147/JIR.S313348

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Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism

Authors: Fumika Ochiai-Homma, Emiko Kuribayashi-Okuma, Yuya Tsurutani, Kenichi Ishizawa, Wataru Fujii, Kohei Odajima, Mika Kawagoe, Yoshihiro Tomomitsu, Masataka Murakawa, Shinichiro Asakawa, Daigoro Hirohama, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Yoshihide Fujigaki, Tetsuo Nishikawa, Shigeru Shibata

Journal: Hypertens Res

PubMed ID: 34326480

Doi: 10.1038/s41440-021-00710-5

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Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy

Authors: Katherine W Cook, Wei Xue, Peter Symonds, Ian Daniels, Mohamed Gijon, David Boocock, Clare Coveney, Amanda K Miles, Sabaria Shah, Suha Atabani, Ruhul H Choudhury, Poonam Vaghela, Daisy Weston, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 34321274

Doi: 10.1136/jitc-2020-001910

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A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in

Authors: Dayana C Farhat, Matthew W Bowler, Guillaume Communie, Dominique Pontier, Lucid Belmudes, Caroline Mas, Charlotte Corrao, Yohann Couté, Alexandre Bougdour, Thierry Lagrange, Mohamed-Ali Hakimi, Christopher Swale

Journal: Elife

PubMed ID: 34263725

Doi: 10.7554/eLife.68312

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ACTH treatment promotes murine cardiac allograft acceptance

Authors: Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S Al Dulaijan, Jamil Azzi, Takaharu Ichimura, Xiaofei Li, Petr Jarolim, Paolo Fiorina, Stefan G Tullius, Joren C Madsen, Vivek Kasinath, Reza Abdi

Journal: JCI Insight

PubMed ID: 34236047

Doi: 10.1172/jci.insight.143385

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Low efficiency of leucocyte plugging-based drug delivery to cancer in mice

Authors: Baifeng Qian, Andreas Termer, Christof M Sommer, Arianeb Mehrabi, Eduard Ryschich

Journal: Drug Deliv Transl Res

PubMed ID: 34319578

Doi: 10.1007/s13346-021-01028-y

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qPCR-based environmental monitoring of Myxobolus cerebralis and phylogenetic analysis of its tubificid hosts in Alberta, Canada

Authors: Danielle E Barry, Marie Veillard, Clayton T James, Leah Brummelhuis, Emmanuel A Pila, Alyssa Turnbull, Arnika Oddy-van Oploo, XinNeng Han, Patrick C Hanington

Journal: Dis Aquat Organ

PubMed ID: 34196282

Doi: 10.3354/dao03608

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miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells

Authors: Arivarasu N Anbazhagan, Shubha Priyamvada, Anoop Kumar, Dulari Jayawardena, Alip Borthakur, Seema Saksena, Ravinder K Gill, Waddah A Alrefai, Pradeep K Dudeja

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34231393

Doi: 10.1152/ajpgi.00148.2021

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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

Authors: Sebastian M Dieter, Christine Siegl, Paula L Codó, Mario Huerta, Anna L Ostermann-Parucha, Erik Schulz, Martina K Zowada, Sylvia Martin, Karin Laaber, Ali Nowrouzi, Mona Blatter, Sina Kreth, Frank Westermann, Axel Benner, Ulrike Uhrig, Kerstin Putzker, Joe Lewis, Andrea Haegebarth, Dominik Mumberg, Simon J Holton, Joerg Weiske, Lena-Marit Toepper, Ulrike Scheib, Gerhard Siemeister, Claudia R Ball, Bernhard Kuster, Gabriele Stoehr, Hannes Hahne, Sarah Johannes, Martin Lange, Friederike Herbst, Hanno Glimm

Journal: Cell Rep

PubMed ID: 34289372

Doi: 10.1016/j.celrep.2021.109394

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Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum

Authors: Larry C Cheng, Dinghai Zheng, Qiang Zhang, Aysegul Guvenek, Hong Cheng, Bin Tian

Journal: Cell Rep

PubMed ID: 34289366

Doi: 10.1016/j.celrep.2021.109407

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A plant CitPITP1 protein-coding exon sequence serves as a promoter in bacteria

Authors: Qingjiang Wu, Jialing Fu, Juan Sun, Xia Wang, Xiaomei Tang, Wenjia Lu, Chen Tan, Li Li, Xiuxin Deng, Qiang Xu

Journal: J Biotechnol

PubMed ID: 34298024

Doi: 10.1016/j.jbiotec.2021.07.011

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Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein

Authors: Devivasha Bordoloi, Ziyang Xu, Michelle Ho, Mansi Purwar, Pratik Bhojnagarwala, Joel Cassel, Leila B Giron, Susanne Walker, Abhijeet J Kulkarni, Edgar Tello Ruiz, Jihae Choi, Faraz I Zaidi, Yuanhan Wu, Shaoying Wang, Ami Patel, Stephanie Ramos, Trevor Smith, Daniel Kulp, Kenneth E Ugen, Alagarsamy Srinivasan, Mohamed Abdel-Mohsen, Laurent Humeau, David B Weiner, Kar Muthumani

Journal: ACS Pharmacol Transl Sci

PubMed ID: 34396059

Doi: 10.1021/acsptsci.1c00058

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Molecular Characterization of Carbonic Anhydrase Genes in and Their Potential Roles in Symbiotic Nitrogen Fixation

Authors: Longlong Wang, Jianjun Liang, Yu Zhou, Tao Tian, Baoli Zhang, Deqiang Duanmu

Journal: Int J Mol Sci

PubMed ID: 34360533

Doi: 10.3390/ijms22157766

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Comparing the relative robustness of anion exchange and the corresponding mixed-mode chromatography on removing a weakly-bound byproduct: A case study of bispecific antibody purification

Authors: Shengwei Zhang, Ting Zhang, Yifeng Li, Yan Wan

Journal: Protein Expr Purif

PubMed ID: 34303809

Doi: 10.1016/j.pep.2021.105948

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A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model

Authors: Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon, Francois Chesnais, Jonathan De Smedt, Tine Tricot, Teresa Izuel Idoype, Marco Canella, Pierre Tilliole, Jolan De Boeck, Manmohan Bajaj, Adrian Ranga, Francesca Maria Bosisio, Tania Roskams, Leo A van Grunsven, Catherine M Verfaillie

Journal: Biomaterials

PubMed ID: 34304139

Doi: 10.1016/j.biomaterials.2021.121006

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A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease

Authors: Zhou Sha, Monica M Montano, Kristy Rochon, Jason A Mears, Daniel Deredge, Patrick Wintrode, Luke Szweda, Natalie Mikita, Irene Lee

Journal: Arch Biochem Biophys

PubMed ID: 34228963

Doi: 10.1016/j.abb.2021.108983

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MIR156-Targeted SPL9 Is Phosphorylated by SnRK2s and Interacts With ABI5 to Enhance ABA Responses in

Authors: Huixue Dong, Suli Yan, Yexing Jing, Ruizhen Yang, Yunwei Zhang, Yun Zhou, Yingfang Zhu, Jiaqiang Sun

Journal: Front Plant Sci

PubMed ID: 34367226

Doi: 10.3389/fpls.2021.708573

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Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level

Authors: Matthew K H Wong, Mulan He, Kong Hung Sze, Tao Huang, Wendy K W Ko, Zhao-Xiang Bian, Anderson O L Wong

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34276561

Doi: 10.3389/fendo.2021.681646

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Elimination of SARS-CoV-2 along wastewater and sludge treatment processes

Authors: Albert Serra-Compte, Susana González, Marina Arnaldos, Sabrina Berlendis, Sophie Courtois, Jean Francois Loret, Olivier Schlosser, Adela M Yáñez, Elena Soria-Soria, Mariana Fittipaldi, Gemma Saucedo, Anna Pinar-Méndez, Miquel Paraira, Belén Galofré, Juan M Lema, Sabela Balboa, Miguel Mauricio-Iglesias, Albert Bosch, Rosa M Pintó, Isabelle Bertrand, Christophe Gantzer, Carlos Montero, Xavier Litrico

Journal: Water Res

PubMed ID: 34330027

Doi: 10.1016/j.watres.2021.117435

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Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery

Authors: Choon Kim, Kiran V Mahasenan, Atul Bhardwaj, Olaf Wiest, Mayland Chang, Shahriar Mobashery

Journal: ACS Omega

PubMed ID: 34337272

Doi: 10.1021/acsomega.1c02984

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Structure of human Ca22 channel blocked by the painkiller ziconotide

Authors: Shuai Gao, Xia Yao, Nieng Yan

Journal: Nature

PubMed ID: 34234349

Doi: 10.1038/s41586-021-03699-6

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A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates importance of Smn for maintenance of mature motor neurons

Authors: Shermaine Huiping Tay, Erna Nur Ellieyana, Yao Le, Menachem Viktor Sarusie, Clemens Grimm, Jürgen Ohmer, Ajay Mathuru, Utz Fischer, Christoph Winkler

Journal: Hum Mol Genet

PubMed ID: 34302176

Doi: 10.1093/hmg/ddab212

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Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity

Authors: Nichole Orench-Rivera, Meta J Kuehn

Journal: Front Microbiol

PubMed ID: 34276573

Doi: 10.3389/fmicb.2021.561863

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Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid

Authors: Francesca Sara Colizzi, Katharina Beer, Paolo Cuti, Peter Deppisch, David Martínez Torres, Taishi Yoshii, Charlotte Helfrich-Förster

Journal: Front Physiol

PubMed ID: 34366893

Doi: 10.3389/fphys.2021.705048

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An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity

Authors: Anne-Catherine Fluckiger, Barthelemy Ontsouka, Jasminka Bozic, Abebaw Diress, Tanvir Ahmed, Tamara Berthoud, Anh Tran, Diane Duque, Mingmin Liao, Michael McCluskie, Francisco Diaz-Mitoma, David E Anderson, Catalina Soare

Journal: Vaccine

PubMed ID: 34304928

Doi: 10.1016/j.vaccine.2021.07.034

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ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta

Authors: Anis Meschichi, Mathieu Ingouff, Claire Picart, Marie Mirouze, Sophie Desset, Franck Gallardo, Kerstin Bystricky, Nathalie Picault, Stefanie Rosa and Frédéric Pontvianne

Journal: Frontier in Plate Science

PubMed ID: 34295343

Doi: 10.3389/fpls.2021.677849

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ANXA10 Promotes Melanoma Metastasis by Suppressing the Ubiquitination of PKD1 Mediated by E3 Ligase TRIM41

Authors: Xuerui Zhang, Zhaoqing Hu, Xinran Wang, Lin Li, Banghui Zhu, Xiaolei Lin, Jing Zhang, Zichun Hua

Journal: Cancer Letters

Doi: doi.org/10.1016/j.canlet.2021.07.033

Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition

Authors: Yun-Yun Fan, Yu-Wei Zhong, Jing Zhao, Yao Chi, Sophie Bouvaine, Shu-Sheng Liu, Susan E Seal, Xiao-Wei Wang

Journal: Cells.

PubMed ID: 34359870

Doi: 10.3390/cells10071700

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First trimester screening with biochemical markers and ultrasound in relation to non-invasive prenatal testing (NIPT)

Authors:

Journal: J Perinat Med

PubMed ID: 34225389

Doi: 10.1515/jpm-2021-0243

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Aberrant Autophagy Impacts Growth and Multicellular Development in a Knockout Model of CLN5 Disease

Authors: Meagan D McLaren, Sabateeshan Mathavarajah, William D Kim, Shyong Q Yap, Robert J Huber

Journal: Front Cell Dev Biol

PubMed ID: 34291044

Doi: 10.3389/fcell.2021.657406

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Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2

Authors: Mitra Gultom, Matthias Licheri, Laura Laloli, Manon Wider, Marina Strässle, Philip V'kovski, Silvio Steiner, Annika Kratzel, Tran Thi Nhu Thao, Lukas Probst, Hanspeter Stalder, Jasmine Portmann, Melle Holwerda, Nadine Ebert, Nadine Stokar-Regenscheit, Corinne Gurtner, Patrik Zanolari, Horst Posthaus, Simone Schuller, Amanda Vicente-Santos, Andres Moreira-Soto, Eugenia Corrales-Aguilar, Nicolas Ruggli, Gergely Tekes, Veronika von Messling, Bevan Sawatsky, Volker Thiel, Ronald Dijkman

Journal: Emerg Infect Dis

PubMed ID: 34152956

Doi: 10.3201/eid2707.204660

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Low neutralizing antibody responses against SARS-CoV-2 in older patients with myeloma after the first BNT162b2 vaccine dose

Authors: Evangelos Terpos, Ioannis P Trougakos, Maria Gavriatopoulou, Ioannis Papassotiriou, Aimilia D Sklirou, Ioannis Ntanasis-Stathopoulos, Eleni-Dimitra Papanagnou, Despina Fotiou, Efstathios Kastritis, Meletios A Dimopoulos

Journal: Blood

PubMed ID: 33861315

Doi: 10.1182/blood.2021011904

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UHRF1 regulates alternative splicing by binding to splicing factors and U snRNAs

Authors: Peng Xu, Lan Zhang, Yao Xiao, Wei Li, Zhiqiang Hu, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei, Wenqiang Yu

Journal: Hum Mol Genet

PubMed ID: 34196368

Doi: 10.1093/hmg/ddab178

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High-resolution characterization of gene function using single-cell CRISPR tiling screen

Authors: Lu Yang, Anthony K N Chan, Kazuya Miyashita, Christopher D Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A Armstrong, Chun-Wei Chen

Journal: Nat Commun

PubMed ID: 34210975

Doi: 10.1038/s41467-021-24324-0

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Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillin resistance of Saccharomyces cerevisiae

Authors: Wenyan Cao, Weiquan Zhao, Bolun Yang, Xinning Wang, Yu Shen, Tiandi Wei, Wensheng Qin, Zailu Li, Xiaoming Bao

Journal: Microb Cell Fact

PubMed ID: 34301255

Doi: 10.1186/s12934-021-01633-z

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Role of a high centrality residue in protein dynamics and thermal stability

Authors: Vitor Medeiros Almeida, Apala Chaudhuri, Marcus Vinicius Cangussu Cardoso, Bruno Yasui Matsuyama, Gláucio Monteiro Ferreira, Gustavo Henrique Goulart Trossini, Roberto Kopke Salinas, J Patrick Loria, Sandro Roberto Marana

Journal: J Struct Biol

PubMed ID: 34320379

Doi: 10.1016/j.jsb.2021.107773

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Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial

Authors: Ana C Medeiros-Ribeiro, Nadia E Aikawa, Carla G S Saad, Emily F N Yuki, Tatiana Pedrosa, Solange R G Fusco, Priscila T Rojo, Rosa M R Pereira, Samuel K Shinjo, Danieli C O Andrade, Percival D Sampaio-Barros, Carolina T Ribeiro, Giordano B H Deveza, Victor A O Martins, Clovis A Silva, Marta H Lopes, Alberto J S Duarte, Leila Antonangelo, Ester C Sabino, Esper G Kallas, Sandra G Pasoto, Eloisa Bonfa

Journal: Nat Med

PubMed ID: 34331051

Doi: 10.1038/s41591-021-01469-5

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RNA-Protein Interaction Analysis of SARS-CoV-2 5' and 3' Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection

Authors: Rohit Verma, Sandhini Saha, Shiv Kumar, Shailendra Mani, Tushar Kanti Maiti, Milan Surjit

Journal: mSystems

PubMed ID: 34254825

Doi: 10.1128/mSystems.00643-21

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Renewable fatty acid ester production in Clostridium

Authors: Jun Feng, Jie Zhang, Yuechao Ma, Yiming Feng, Shangjun Wang, Na Guo, Haijiao Wang, Pixiang Wang, Pablo Jiménez-Bonilla, Yanyan Gu, Junping Zhou, Zhong-Tian Zhang, Mingfeng Cao, Di Jiang, Shuning Wang, Xian-Wei Liu, Zengyi Shao, Ilya Borovok, Haibo Huang, Yi Wang

Journal: Nat Commun

PubMed ID: 34272383

Doi: 10.1038/s41467-021-24038-3

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Syntrophy of Crypthecodinium cohnii and immobilized Zymomonas mobilis for docosahexaenoic acid production from sucrose-containing substrates

Authors: Inese Strazdina, Linards Klavins, Nina Galinina, Karlis Shvirksts, Mara Grube, Egils Stalidzans, Uldis Kalnenieks

Journal: J Biotechnol

PubMed ID: 34280360

Doi: 10.1016/j.jbiotec.2021.07.008

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Novel insights into the immune regulatory effects of Megalobrama amblycephala intelectin on the phagocytosis and killing activity of macrophages

Authors: Yancui Zheng, Yunlong Liu, Hongping Li, Xu Wang, Minying Zhang, Xin Shen, Hanliang Cheng, Jianhe Xu, Xingqiang Wang, Hong Liu, Zhujin Ding, Xiaoheng Zhao

Journal: Mol Immunol

PubMed ID: 34247100

Doi: 10.1016/j.molimm.2021.06.008

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Mutation in Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability

Authors: Sara A Lewis, Somayeh Bakhtiari, Jennifer Heim, Patricia Cornejo, James Liu, Aris Huang, Andrew Musmacker, Sheng Chih Jin, Kaya Bilguvar, Sergio R Padilla-Lopez, Michael C Kruer

Journal: Neurol Genet

PubMed ID: 34345675

Doi: 10.1212/NXG.0000000000000602

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Influence of Subcellular Localization and Functional State on Protein Turnover

Authors: Roya Yousefi, Kristina Jevdokimenko, Verena Kluever, David Pacheu-Grau, Eugenio F Fornasiero

Journal: Cells

PubMed ID: 34359917

Doi: 10.3390/cells10071747

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Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer

Authors: Yukie Kashima, Daisuke Shibahara, Ayako Suzuki, Kyoko Muto, Ikei S Kobayashi, David Plotnick, Hibiki Udagawa, Hiroki Izumi, Yuji Shibata, Kosuke Tanaka, Masanori Fujii, Akihiro Ohashi, Masahide Seki, Koichi Goto, Katsuya Tsuchihara, Yutaka Suzuki, Susumu S Kobayashi

Journal: Cancer Res

PubMed ID: 34247147

Doi: 10.1158/0008-5472.CAN-20-2811

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