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SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Authors: Pan Pan; Miaomiao Shen; Zhenyang Yu; Weiwei Ge; Keli Chen; Mingfu Tian; Feng Xiao; Zhenwei Wang; Jun Wang; Yaling Jia; Wenbiao Wang; Pin Wan; Jing Zhang; Weijie Chen; Zhiwei Lei; Xin Chen; Zhen Luo; Qiwei Zhang; Meng Xu; Geng Li; Yongkui Li; Jianguo Wu

Journal: Nature Communications

PubMed ID: 34341353

Doi: 10.1038/s41467-021-25015-6

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling

Authors: Zheyue Wang; Qi Tang; Bende Liu; Wenqing Zhang; Yufeng Chen; Ningfei Ji; Yan Peng; Xiaohui Yang; Daixun Cui; Weiyu Kong; Xiaojun Tang; Tingting Yang; Mingshun Zhang; Xinxia Chang; Jin Zhu; Mao Huang; Zhenqing Feng

Journal: Journal of biomedical research

PubMed ID: 36992606

Doi: 10.7555/JBR.36.20220221

Structure and activation mechanism of the hexameric plasma membrane H+-ATPase

Authors: Peng Zhao, Chaoran Zhao, Dandan Chen, Caihong Yun, Huilin Li, Lin Bai

Journal: Nat Commun.

PubMed ID: 34750373

Doi: 10.1038/s41467-021-26782-y

Products & Services: Protein and Antibody Isolation

Efficient DNA interrogation of SpCas9 governed by its electrostatic interaction with DNA beyond the PAM and protospacer

Authors: Qian Zhang, Ziting Chen, Fangzhu Wang, Siqi Zhang, Hongyu Chen, Xueying Gu, Fengcai Wen, Jiachuan Jin, Xia Zhang, Xingxu Huang

Journal: Nucleic Acids Research

Doi: 10.1093/nar/gkab1139

Products & Services: Protein and Antibody Isolation

RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association

Authors: Valérie C Cabana, Antoine Y Bouchard, Audrey M Sénécal, Kim Ghilarducci, Saïd Kourrich, Laurent Cappadocia, Marc P Lussier

Journal: Cells

PubMed ID: 34831286

Doi: 10.3390/cells10113063 Free PMC article

Products & Services: Gene Synthesis

Noncanonical ER-Golgi trafficking and autophagy of endogenous procollagen in osteoblasts

Authors: Laura Gorrell, Shakib Omari, Elena Makareeva, Sergey Leikin

Journal: Cell Mol Life Sci

PubMed ID: 34779895

Doi: 10.1007/s00018-021-04017-z

Products & Services: Synthetic Guide RNA Gene Synthesis

Association Between Brain Structural Network Efficiency at Term-Equivalent Age and Early Development of Cerebral Palsy in Very Preterm Infants

Authors: Julia E Kline, Weihong Yuan, Karen Harpster, Mekibib Altaye, Nehal A Parikh

Journal: Neuroimage

PubMed ID: 34758381

Doi: 10.1016/j.neuroimage.2021.118688

Products & Services: Recombinant Proteins

Preparation of Specific Nanobodies and Their Application in the Rapid Detection of Nodularin-R in Water Samples

Authors: Jinyi Yang, Rui Si, Guangpei Wu, Yu Wang, Ruyu Fang, Fei Liu, Feng Wang, Hongtao Lei, Yudong Shen, Qi Zhang, Hong Wang

Journal: Foods

PubMed ID: 34829042

Doi: 10.3390/foods10112758

Products & Services: Recombinant Antibody Expression

Comparison of SARS-CoV-2 Antibody Responses and Seroconversion in COVID-19 Patients Using Twelve Commercial Immunoassays

Authors: Sojeong Yun, Ji Hyeong Ryu, Joo Hee Jang, Hyunjoo Bae, Seung-Hyo Yoo, Ae-Ran Choi, Sung Jin Jo, Jihyang Lim, Jehoon Lee, Hyejin Ryu, Sung-Yeon Cho, Dong-Gun Lee, Jongmin Lee, Seok Chan Kim, Yeon-Joon Park, Hyeyoung Lee, Eun-Jee Oh

Journal: Ann Lab Med

PubMed ID: 34108285

Doi: 10.3343/alm.2021.41.6.577

Products & Services: Protein and Antibody Isolation

Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay

Authors: Liding Zhang, Xuewei Du, Ying Su, Shiqi Niu, Yanqing Li, Xiaohan Liang, Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 34789291

Doi: 10.1186/s12951-021-01111-z

Products & Services: Protein and Antibody Isolation Protein and Antibody Isolation

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain

Authors: Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L Stucky, Quinn H Hogan, Hongwei Yu

Journal: Pain

PubMed ID: 34285153

Doi: 10.1097/j.pain.0000000000002356

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Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling

Authors: Dahong Chen, Catherine E McManus, Behram Radmanesh, Leah H Matzat, Elissa P Lei

Journal: Nat Commun

PubMed ID: 34737269

Doi: 10.1038/s41467-021-26628-7

Products & Services: Plasmid DNA Preparation

Transformation of Reactive Blue 19 by a recombinant peroxidase DyP

Authors: Qian Pi, Zhubing Zhu, Lei Tang

Journal: Bioprocess Biosyst Eng

PubMed ID: 34739595

Doi: 10.1007/s00449-021-02660-1

Products & Services: Plasmid DNA Preparation

Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

Authors: Mingyue Hou, Wenfang Bao, Yuanyuan Gao, Jiayue Chen, Guijun Song

Journal: Chem Biol Interact

PubMed ID: 34752757

Doi: 10.1016/j.cbi.2021.109741

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Modulating Oncolytic Adenovirus Immunotherapy by Driving Two Axes of the Immune System by Expressing 4-1BBL and CD40L

Authors: Shao-Chia Lu, Michael Hansen, Jack Hemsath, Brian Parrett, Brady Zell, Michael A Barry

Journal: Hum Gene Ther

PubMed ID: 34731019

Doi: 10.1089/hum.2021.197

Products & Services: Peptide Synthesis

Effective discrimination of gas-phase peptide conformers using TIMS-ECD-ToF MS/MS

Authors: K Jeanne Dit Fouque, M Wellmann, D Leyva Bombuse, M Santos-Fernandez, Y L Cintron-Diaz, M E Gomez-Hernandez, D Kaplan, V G Voinov, F Fernandez-Lima

Journal: Anal Methods

PubMed ID: 34698320

Doi: 10.1039/d1ay01461g

Products & Services: ORF cDNA Clones/MolecularCloud

Author Correction: Regulation of local GTP availability controls RAC1 activity and cell invasion

Authors: Anna Bianchi-Smiraglia, David W Wolff, Daniel J Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M Wombacher, Ashley L Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O'Brien Cox, Cristina M Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J Sousa, Mikhail E Kandel, Eugene S Kandel, Klaus M Hahn, Mikhail A Nikiforov

Journal: Nat Commun

PubMed ID: 34741006

Doi: 10.1038/s41467-021-26665-2

Products & Services: Mutant Libraries

Molecular Detection and Characterization of in Farmed Pigs in Three Provinces of Southern China

Authors: Yang Zou, Xiao-Dan Yuan, Sheng-Ying Zhang, Hong-Yan Zhang, Xiao-Qing Chen

Journal: Pathogens

PubMed ID: 34832636

Doi: 10.3390/pathogens10111481

Products & Services: DNA Sequencing

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1

Authors: Li Huang, Wenjie Xu, Hongyang Liu, Mengdi Xue, Xiaohong Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Xuemin Liu, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu, Tao Xiong, Changjiang Weng

Journal: J Immunol

PubMed ID: 34759016

Doi: 10.4049/jimmunol.2100320

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Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein

Authors: Mary C Andorfer, Lindsey R F Backman, Phoebe L Li, Emily C Ulrich, Catherine L Drennan

Journal: J Biol Chem

PubMed ID: 34801558

Doi: 10.1016/j.jbc.2021.101423

Products & Services: Codon Optimization

Engineering Cupriavidus necator DSM 545 for the one-step conversion of starchy waste into polyhydroxyalkanoates

Authors: Silvia Brojanigo, Nicoletta Gronchi, Tiziano Cazzorla, Tuck Seng Wong, Marina Basaglia, Lorenzo Favaro, Sergio Casella

Journal: Bioresour Technol

PubMed ID: 34808314

Doi: 10.1016/j.biortech.2021.126383

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Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus

Authors: Alexandra Vaisman, John P McDonald, Mallory R Smith, Sender L Aspelund, Thomas C Evans, Roger Woodgate

Journal: Front Mol Biosci

PubMed ID: 34805283

Doi: 10.3389/fmolb.2021.778400

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Evaluation of Cellular Immunity with ASFV Infection by Swine Leukocyte Antigen (SLA)-Peptide Tetramers

Authors: Wenqiang Sun, He Zhang, Wenhui Fan, Lihong He, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Rongliang Hu, Tingrong Luo, Wenjun Liu, Jing Li

Journal: Viruses

PubMed ID: 34835070

Doi: 10.3390/v13112264

Products & Services: Codon Optimization

Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen

Authors: Andrey M Grishin, Nataliya V Dolgova, Shelby Landreth, Olivier Fisette, Ingrid J Pickering, Graham N George, Darryl Falzarano, Miroslaw Cygler

Journal: J Mol Biol

PubMed ID: 34780781

Doi: 10.1016/j.jmb.2021.167357

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Structure of procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

Authors: Edem Gavor, Yeu Khai Choong, Nikhil Kumar Tulsian, Digant Nayak, Fakhriedzwan Idris, Hariharan Sivaraman, Donald Heng Rong Ting, Alonso Sylvie, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Life Sci Alliance

PubMed ID: 34750241

Doi: 10.26508/lsa.202101211

Products & Services: Codon Optimization

Tyrosinase-based production of L-DOPA by Corynebacterium glutamicum

Authors: Eldin Kurpejović, Volker F Wendisch, Berna Sariyar Akbulut

Journal: Appl Microbiol Biotechnol

PubMed ID: 34762142

Doi: 10.1007/s00253-021-11681-5

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Overexpression of the rice BAHD acyltransferase AT10 increases xylan-bound p-coumarate and reduces lignin in Sorghum bicolor

Authors: Yang Tian, Chien-Yuan Lin, Joon-Hyun Park, Chuan-Yin Wu, Ramu Kakumanu, Venkataramana R Pidatala, Khanh M Vuu, Alberto Rodriguez, Patrick M Shih, Edward E K Baidoo, Stephen Temple, Blake A Simmons, John M Gladden, Henrik V Scheller, Aymerick Eudes

Journal: Biotechnol Biofuels

PubMed ID: 34801067

Doi: 10.1186/s13068-021-02068-9

Products & Services: Codon Optimization

A novel DNA platform designed for vaccine use with high transgene expression and immunogenicity

Authors: George Giorgi Babuadze, Jose Echanove, Claude Lamarre, Marc-Antoine deLaVega, Hugues Fausther-Bovendo, Trina Racine, Alejandro M Gomez, Hiva Azizi, Mathew Wade, Robert Kozak, Gary P Kobinger

Journal: Vaccine

PubMed ID: 34774358

Doi: 10.1016/j.vaccine.2021.10.008

Products & Services: Catalog Antibodies

Insulin-activated store-operated Ca entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Authors: Ji-Hee Kim, Kyu-Hee Hwang, Bao T N Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, Seung-Kuy Cha

Journal: Nat Commun

PubMed ID: 34764278

Doi: 10.1038/s41467-021-26900-w

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Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells

Authors: Shuya Kyu, Richard P Ramonell, Merin Kuruvilla, Colleen S Kraft, Yun F Wang, Ann R Falsey, Edward E Walsh, John L Daiss, Simon Paulos, Gowrisankar Rajam, Hao Wu, Srinivasan Velusamy, F Eun-Hyung Lee

Journal: PLoS ONE

PubMed ID: 34767590

Doi: 10.1371/journal.pone.0259644

Products & Services: Bacterial Expression

Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Authors: Jinhye Ryu, Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34826501

Doi: 10.1016/j.dci.2021.104324

Products & Services: Gene Synthesis

New and efficient purification process for recombinant human insulin produced in Escherichia coli

Authors: Yin Yin Siew, Amrita Rai, Han Bin Pek, Dave Siak-Wei Ow, Wei Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 34821966

Doi: 10.1007/s00253-021-11697-x

Products & Services: Bacterial Expression

Improved the Activity of Phosphite Dehydrogenase and its Application in Plant Biotechnology

Authors: Tongtong Liu, Lili Yuan, Suren Deng, Xiangxian Zhang, Hongmei Cai, Guangda Ding, Fangsen Xu, Lei Shi, Gaobing Wu, Chuang Wang

Journal: Front Bioeng Biotechnol

PubMed ID: 34900961

Doi: 10.3389/fbioe.2021.764188

Products & Services: Gene Synthesis

Recombinant Bacillus subtilis flagellin Hag is a potent immunostimulant with reduced proinflammatory properties compared to Salmonella enterica serovar Typhimurium FljB

Authors: Mélanie Côté-Cyr, Laurie Gauthier, Ximena Zottig, Steve Bourgault, Denis Archambault

Journal: Vaccine

PubMed ID: 34844822

Doi: 10.1016/j.vaccine.2021.11.049

Products & Services: Gene Synthesis

Enhancing the resilience of transgenic cotton for insect resistance

Authors: Mohsin Shad, Aneela Yasmeen, Saira Azam, Allah Bakhsh, Ayesha Latif, Naila Shahid, Sahar Sadaqat, Abdul Qayyum Rao, Ahmad Ali Shahid

Journal: Mol Biol Rep

PubMed ID: 34839448

Doi: 10.1007/s11033-021-06972-z

Products & Services: Protein and Antibody Isolation

Inhibition of SGLT1 alleviates the glycemic variability-induced cardiac fibrosisvia inhibiting activations of macrophage and cardiac fibroblast

Authors: Weihua Wu, Qian Chai, Ziying Zhang

Journal: MOL CELL BIOL

PubMed ID: 34842443

Doi: 10.1128/MCB.00282-21

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Genetic manipulation of trehalose-6-phosphate synthase results in changes in the soluble sugar profile in transgenic sugarcane stems

Authors: Casey Gabriel, Jean-Jacque Fernhout, Franziska Fichtner, Regina Feil, John E Lunn, Jens Kossmann, James R Lloyd, Christell van der Vyver

Journal: Plant Direct

PubMed ID: 34765864

Doi: 10.1002/pld3.358

Products & Services: Gene Synthesis

MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs

Authors: Kien Lam Ung, Husam Alsarraf, Laurent Kremer, Mickaël Blaise

Journal: Protein Expr Purif

PubMed ID: 34767949

Doi: 10.1016/j.pep.2021.106014

Products & Services: Peptide Synthesis

A SYBR Green-based real-time RT-PCR assay to differentiate the H1N1 influenza virus lineages

Authors: Yulin Cong, Yixue Sun, Xiaoyu Deng, Haiying Yu, Xiaohuan Lian, Yanlong Cong

Journal: J Virol Methods

PubMed ID: 34848281

Doi: 10.1016/j.jviromet.2021.114387

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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis

Authors: Charles J Cho, Dongkook Park, Jason C Mills

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34816763

Doi: 10.1152/ajpgi.00246.2021

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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Authors: Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

Journal: Oncoimmunology

PubMed ID: 34858730

Doi: 10.1080/2162402X.2021.2005344

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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang, Hongyi Zhang

Journal: Cell Mol Biol Lett

PubMed ID: 34837962

Doi: 10.1186/s11658-021-00295-4

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Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin

Authors: Maria Petrosino, Francesco Stellato, Roberta Chiaraluce, Valerio Consalvi, Giovanni La Penna, Alessandra Pasquo, Olivier Proux, Giancarlo Rossi, Silvia Morante

Journal: ChemistryOpen

PubMed ID: 34791819

Doi: 10.1002/open.202100217

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H, N and C resonance assignments of the Q61H mutant of human KRAS bound to GDP

Authors: Qiwei Huang, Elizabeth Yihui Ng, Qingxin Li, CongBao Kang

Journal: Biomol NMR Assign

PubMed ID: 34787842

Doi: 10.1007/s12104-021-10058-z

Products & Services: Mammalian Expression

Refinement and Neutralization Evaluation of the F(ab') Type of Antivenom against the Deadly Jellyfish Toxins

Authors: Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li

Journal: Int J Mol Sci

PubMed ID: 34884477

Doi: 10.3390/ijms222312672

Products & Services: Protein and Antibody Isolation

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Authors: Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R Wilmore, Brian T Gaudette, Ousamah Y Soliman, Matthew Pine, Philip Hicks, Tomaz B Manzoni, James J Knox, John L Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M Rosenfeld, Shirin Strohmeier, Paulo J C Lin, Barbara L Mui, Ying K Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P Cancro, Drew Weissman, Eline T Luning Prak, David Allman, Michela Locci, Norbert Pardi

Journal: Immunity

PubMed ID: 34852217

Doi: 10.1016/j.immuni.2021.11.001

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Mediates Hormonally Regulated Dominance Rank in a Social Bee

Authors: Atul Pandey, Guy Bloch

Journal: Biology (Basel)

PubMed ID: 34827180

Doi: 10.3390/biology10111188

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Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E coli without loss of activity

Authors: Melis Denizci Öncü, Bertan Koray Balcıoğlu, Beytullah Özgür, Hasan Ümit Öztürk, Müge Serhatlı, Şeyma Işık, Berrin Erdağ, Gizem Dinler Doğanay, Aylin Özdemir Bahadır

Journal: Biotechnol Appl Biochem

PubMed ID: 34694021

Doi: 10.1002/bab.2273

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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru

Journal: Cell Rep

PubMed ID: 34758302

Doi: 10.1016/j.celrep.2021.109989

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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses

Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek

Journal: Mol Syst Biol

PubMed ID: 34806839

Doi: 10.15252/msb.202110560

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WRKY2 and WRKY10 regulate the circadian expression of during the day through interactions with CCA1/LHY and phyB

Authors: Shulei Wang, Qingbin Sun, Min Zhang, Chengzhu Yin, Min Ni

Journal: Plant Commun

PubMed ID: 35529947

Doi: 10.1016/j.xplc.2021.100265

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Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model

Authors: Monique C P Mendonça, Michael F Cronin, John F Cryan, Caitriona M O'Driscoll

Journal: Eur J Pharm Biopharm

PubMed ID: 34793942

Doi: 10.1016/j.ejpb.2021.11.003

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Endotoxin Acts Synergistically With Clostridioides difficile Toxin B to Increase Interleukin 1β Production: A Potential Role for the Intestinal Biome in Modifying the Severity of C difficile Colitis

Authors: Pyae Htwe, Htay Aung, Bohm Kywe, Phyu T Niang, Thar Sann Oo, Sindhu Monhandas, Libusha Kelly, David L Goldman

Journal: J Infect Dis

PubMed ID: 33780547

Doi: 10.1093/infdis/jiab165

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Mitochondrial Localization Signal of Porcine Circovirus Type 2 Capsid Protein Plays a Critical Role in Cap-Induced Apoptosis

Authors: Wanting Yu, Yuao Sun, Qing He, Chaoying Sun, Tian Dong, Luhua Zhang, Yang Zhan, Naidong Wang, Yi Yang, Yujie Sun

Journal: Vet Sci

PubMed ID: 34822645

Doi: 10.3390/vetsci8110272

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TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ

Authors: Ruixue Li, Renyong Wang, Shijie Zhong, Farhan Asghar, Tiehan Li, Lei Zhu, Hong Zhu

Journal: Open Life Sci

PubMed ID: 34761110

Doi: 10.1515/biol-2021-0118

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Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes

Authors: Yue Lang, Fengna Chu, Lingling Liu, Chao Zheng, Chunrong Li, Donghui Shen, Shan Liu, Weiguanliu Zhang, Li Cui, Jie Zhu

Journal: Clin Exp Immunol

PubMed ID: 35020839

Doi: 10.1093/cei/uxab022

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Inducing I and phase 1 repolarization of the cardiac action potential with a Kv43/KChIP21 bicistronic transgene

Authors: Nan Wang, Eef Dries, Ewan D Fowler, Stephen C Harmer, Jules C Hancox, Mark B Cannell

Journal: J Mol Cell Cardiol

PubMed ID: 34823101

Doi: 10.1016/j.yjmcc.2021.11.004

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome

Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan

Journal: Microbiome

PubMed ID: 34814938

Doi: 10.1186/s40168-021-01147-1

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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection

Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon

Journal: Viruses

PubMed ID: 34835083

Doi: 10.3390/v13112277

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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

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Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts

Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo

Journal: Front Cell Infect Microbiol

PubMed ID: 34869065

Doi: 10.3389/fcimb.2021.758898

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Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick

Journal: MBio

PubMed ID: 34749532

Doi: 10.1128/mBio.02573-21

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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia

Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati

Journal: J Mol Neurosci

PubMed ID: 34811713

Doi: 10.1007/s12031-021-01945-0

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CD4+ effector T cells accelerate Alzheimer's disease in mice

Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman

Journal: J Neuroinflammation

PubMed ID: 34798897

Doi: 10.1186/s12974-021-02308-7

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Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p

Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang

Journal: Cancer Cell Int

PubMed ID: 34844630

Doi: 10.1186/s12935-021-02353-5

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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf

Journal: MBio

PubMed ID: 34724812

Doi: 10.1128/mBio.02558-21

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Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu

Journal: Int J Mol Sci

PubMed ID: 34884691

Doi: 10.3390/ijms222312886

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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response

Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 34818332

Doi: 10.1371/journal.pntd.0009949

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Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction

Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang

Journal: J Clin Invest

PubMed ID: 34752417

Doi: 10.1172/JCI151268

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Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases

Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent

Journal: J Bacteriol

PubMed ID: 34843376

Doi: 10.1128/JB.00498-21

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Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging

Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan

Journal: Sci Rep

PubMed ID: 34845270

Doi: 10.1038/s41598-021-02445-2

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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

Journal: Elife

PubMed ID: 34761751

Doi: 10.7554/eLife.72798

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Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs

Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink

Journal: J Biol Chem

PubMed ID: 34798071

Doi: 10.1016/j.jbc.2021.101421

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang

Journal: Structure

PubMed ID: 34793709

Doi: 10.1016/j.str.2021.10.013

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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae

Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen

Journal: Appl Microbiol Biotechnol

PubMed ID: 34738171

Doi: 10.1007/s00253-021-11661-9

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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee

Journal: Nat Commun

PubMed ID: 34785657

Doi: 10.1038/s41467-021-26733-7

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Authors: Merveille Eguida, Didier Rognan

Journal: J Cheminform

PubMed ID: 34814950

Doi: 10.1186/s13321-021-00567-3

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High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study

Authors: Andres Moreira-Soto, Johanna Maribel Pachamora Diaz, Lilian González-Auza, Xiomara Jeanleny Merino Merino, Alvaro Schwalb, Christian Drosten, Eduardo Gotuzzo, Michael Talledo, Heriberto Arévalo Ramirez, Roxana Peralta Delgado, Spassky Bocanegra Vargas, Jan Felix Drexler

Journal: mSphere

PubMed ID: 34817236

Doi: 10.1128/mSphere.00685-21

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee, Chae Rim Lee, Da-Som Kim, Yang-Mi Her, Jeong Won Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

Journal: Cell Mol Immunol

PubMed ID: 34782759

Doi: 10.1038/s41423-021-00798-2

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A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins

Authors: Gang Liu, Dong-Yun Zuo, Peng Yang, Wei-Jie He, Zheng Yang, Jing-Bo Zhang, Ai-Bo Wu, Shu-Yuan Yi, He-Ping Li, Tao Huang, Yu-Cai Liao

Journal: J Fungi (Basel)

PubMed ID: 34829228

Doi: 10.3390/jof7110941

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The multicellular signalling network of ovarian cancer metastases

Authors: Leah Sommerfeld, Florian Finkernagel, Julia M Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Anna M Sokol, Johannes Graumann, Silke Reinartz, Rolf Müller

Journal: Clin Transl Med

PubMed ID: 34841720

Doi: 10.1002/ctm2.633

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The barley HvSTP13GR mutant triggers resistance against biotrophic fungi

Authors: Caroline Ines Skoppek, Wilko Punt, Marleen Heinrichs, Frank Ordon, Gwendolin Wehner, Jens Boch, Jana Streubel

Journal: Mol Plant Pathol

PubMed ID: 34816582

Doi: 10.1111/mpp.13161

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Influence of flagellin polymorphisms, gene regulation, and responsive memory on the motility of species that cause bacterial spot disease of solanaceous plants

Authors: Maria Laura Malvino, Amie Joy Bott, Cory Edwin Green, Tanvi Majumdar, Sarah Refi Hind

Journal: Mol Plant Microbe Interact

PubMed ID: 34732057

Doi: 10.1094/MPMI-08-21-0211-R

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CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Authors: Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G Venugopala Reddy

Journal: Nat Commun

PubMed ID: 34737298

Doi: 10.1038/s41467-021-26586-0

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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication

Authors: Sai Wang, Kitti Wing Ki Chan, Min Jie Alvin Tan, Charlotte Flory, Dahai Luo, Julian Lescar, Jade K Forwood, Subhash G Vasudevan

Journal: RNA

PubMed ID: 34759006

Doi: 10.1261/rna.078949.121

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HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

Authors: Man Chen; Madhav C. Menon; Wenlin Wang; Jia Fu; Zhengzi Yi; Zeguo Sun; Jessica Liu; Zhengzhe Li; Lingyun Mou; Khadija Banu; Sui-Wan Lee; Ying Dai; Nanditha Anandakrishnan; Evren U. Azeloglu; Kyung Lee; Weijia Zhang; Bhaskar Das; John Cijiang He; Chengguo Wei

Journal: Nature Communications

PubMed ID: 37463911

Doi: 10.1038/s41467-023-40086-3

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Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment

Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 34740282

Doi: 10.1111/bcpt.13681

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An Efficient Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Protein 9 Mutagenesis System for Oil Palm ()

Authors: Wan-Chin Yeap, Muhammad Rashdan Muad, David Ross Appleton

Journal: Front Plant Sci

PubMed ID: 34880893

Doi: 10.3389/fpls.2021.773656

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Long Non-Coding RNA Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development

Authors: Elpinickie Ninou, Artemis Michail, Panagiotis K Politis

Journal: Front Cell Dev Biol

PubMed ID: 34900989

Doi: 10.3389/fcell.2021.726857

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Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

Authors: Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya M Colpitts, Stephanie E Mohr, Yanhui Hu, Norbert Perrimon

Journal: Nat Commun

PubMed ID: 34819517

Doi: 10.1038/s41467-021-27129-3

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SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells

Authors: Dante Barreda, César Santiago, Juan R Rodríguez, José F Rodríguez, José M Casasnovas, Isabel Mérida, Antonia Ávila-Flores

Journal: Cells

PubMed ID: 34943787

Doi: 10.3390/cells10123279

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A novel chimeric protein with enhanced cytotoxic effects on breast cancer in vitro and in vivo

Authors: Fereshte Hazrati, Massoud Saidijam, Yaghoub Ahmadyousefi, Fatemeh Nouri, Hamidreza Ghadimipour, Mohammadreza Moradi, Rasool Haddadi, Meysam Soleimani

Journal: Proteins

PubMed ID: 34812523

Doi: 10.1002/prot.26285

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Diagnostic Performance of Self-Collected Saliva Versus Nasopharyngeal Swab for the Molecular Detection of SARS-CoV-2 in the Clinical Setting

Authors: Mohammad Khaja Mafij Uddin, Tahmina Shirin, Mohammad Enayet Hossain, Ahmed Nawsher Alam, Jenifar Quaiyum Ami, Rashedul Hasan, Mojnu Miah, Nusrat Jahan Shaly, Shahriar Ahmed, S M Mazidur Rahman, Mustafizur Rahman, Sayera Banu

Journal: Microbiol Spectr

PubMed ID: 34730436

Doi: 10.1128/Spectrum.00468-21

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Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species

Authors: Xinchen Jiang, Junliang Yin, Lixin Wang, Keyong Xi, Xiongmeng Zhu, Gang Li, Yongxing Zhu, Yiqing Liu

Journal: Plant Genome

PubMed ID: 34741493

Doi: 10.1002/tpg2.20167

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Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

Authors: Andrea Moreno, Victor Taleb, María Sebastián, Ernesto Anoz-Carbonell, Marta Martínez-Júlvez, Milagros Medina

Journal: IUBMB Life

PubMed ID: 34813144

Doi: 10.1002/iub.2576

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A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity

Authors: Wanying Zhang, Haiyang Li, Limin Wang, Shunpei Xie, Yuan Zhang, Ruijiao Kang, Mengjuan Zhang, Panpan Zhang, Yonghui Li, Yanfeng Hu, Min Wang, Linlin Chen, Hongxia Yuan, Shengli Ding, Honglian Li

Journal: Mol Plant Pathol

PubMed ID: 34741560

Doi: 10.1111/mpp.13155

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