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A plant reovirus hijacks the DNAJB12-Hsc70 chaperone complex to promote viral spread in its planthopper vector

Authors: Qifu Liang, Jiajia Wan, Huan Liu, Manni Chen, Taoran Xue, Dongsheng Jia, Qian Chen, Hongyan Chen, Taiyun Wei

Journal: Mol Plant Pathol

PubMed ID: 34668642

Doi: 10.1111/mpp.13152

Products & Services: PCR and Cloning

Cellular Effects of 2´,3´-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria

Authors: Yashasvika Duggal, Jennifer E Kurasz, Benjamin M Fontaine, Nick J Marotta, Shikha S Chauhan, Anna C Karls, Emily E Weinert

Journal: J Bacteriol

PubMed ID: 34662237

Doi: 10.1128/JB.00208-21

Products & Services: Codon Optimization

Short-term immune response after inactivated SARS-CoV-2 (CoronaVac®, Sinovac) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-AstraZeneca) vaccinations in health care workers

Authors: Watsamon Jantarabenjakul, Napaporn Chantasrisawad, Thanyawee Puthanakit, Supaporn Wacharapluesadee, Nattiya Hirankarn, Vichaya Ruenjaiman, Leilani Paitoonpong, Gompol Suwanpimolkul, Pattama Torvorapanit, Rakchanok Pradit, Jiratchaya Sophonphan, Opass Putcharoen

Journal: Asian Pac J Allergy Immunol

PubMed ID: 34717527

Doi: 10.12932/AP-250721-1197

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes

Authors: Yingjuan J Lu, Leroy W Wheeler, Haiyan Chu, Paul J Kleindl, Michael Pugh, Fei You, Satish Rao, Gabriela Garcia, Henry Y Wu, Andre P da Cunha, Richard Johnson, Elaine Westrick, Vicky Cross, Alex Lloyd, Christina Dircksen, Patrick J Klein, Iontcho R Vlahov, Philip S Low, Christopher P Leamon

Journal: Cell Rep Med

PubMed ID: 34755134

Doi: 10.1016/j.xcrm.2021.100422

Products & Services: Mammalian Expression

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Authors: Sophie Sluysmans, Isabelle Méan, Tong Xiao, Amina Boukhatemi, Flavio Ferreira, Lionel Jond, Annick Mutero, Christopher J Chang, Sandra Citi

Journal: Mol Biol Cell

PubMed ID: 34613798

Doi: 10.1091/mbc.E21-07-0355

Products & Services: Molecular Biology Tools

Limited impact of Delta variantâ€™s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: medrxiv

PubMed ID: 34729566

Doi: 10.1101/2021.10.25.21265422

Products & Services: Recombinant Proteins

Rational engineering of a functional CpG-free ITR for AAV gene therapy

Authors: Xiufang Pan, Yongping Yue, Maria Boftsi, Lakmini P Wasala, Ngoc Tam Tran, Keqing Zhang, David J Pintel, Phillip W L Tai, Dongsheng Duan

Journal: Gene Ther

PubMed ID: 34611321

Doi: 10.1038/s41434-021-00296-0

Products & Services: Recombinant Proteins

Comprehensive Analysis of Transcriptome-wide mA Methylome Upon Beta2 Toxin Exposure in Porcine Intestinal Epithelial Cells by mA Sequencing

Authors: Juanli Zhang, Qiaoli Yang, Jiaojiao Yang, Xiaoli Gao, Ruirui Luo, Xiaoyu Huang, Zunqiang Yan, Pengfei Wang, Wei Wang, Kaihui Xie, Bo Zhang, Shuangbao Gun

Journal: Front Genet

PubMed ID: 34737761

Doi: 10.3389/fgene.2021.689748

Products & Services: Proteins, Expression, Isolation and Analysis

Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria

Authors: Yanping Zhang, Han Xiao, Qiuhong Xiong, Changxin Wu, Ping Li

Journal: Int J Mol Sci

PubMed ID: 34681668

Doi: 10.3390/ijms222011008

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Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma

Authors: Mari K Halle, Aishwarya Sundaresan, Jianqing Zhang, Chandra Sekhar Pedamallu, Vinodh Srinivasasainagendra, Jessica Blair, Dewey Brooke, Bjørn I Bertelsen, Kathrine Woie, Sadeep Shrestha, Hemant Tiwari, Yick Fu Wong, Camilla Krakstad, Akinyemi I Ojesina

Journal: NPJ Genom Med

PubMed ID: 34620846

Doi: 10.1038/s41525-021-00244-2

Products & Services: Gene Synthesis

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice

Authors: Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi

Journal: PeerJ

PubMed ID: 34721976

Doi: 10.7717/peerj.12285

Products & Services: Plasmid DNA Preparation

Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

Authors: Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M Gruntman, Guangping Gao, Terence R Flotte, Allison M Keeler

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34853797

Doi: 10.1016/j.omtm.2021.10.010

Products & Services: Peptide Synthesis

Programmable nano-reactors for stochastic sensing

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yuming Gu, Guangrui Qian, Xiaoyu Du, Liying Wang, Yao Liu, Jiao Cao, Shanyu Zhang, Shuanghong Yan, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: Nat Commun.

PubMed ID: 34608151

Doi: 10.1038/s41467-021-26054-9

Products & Services: Single-Stranded DNA Synthesis

Structural basis of the P4B ATPase lipid flippase activity

Authors: Lin Bai, Bhawik K Jain, Qinglong You, H Diessel Duan, Mehmet Takar, Todd R Graham, Huilin Li

Journal: Nat Commun

PubMed ID: 34645814

Doi: 10.1038/s41467-021-26273-0

Products & Services: Proteins, Expression, Isolation and Analysis

Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study

Authors: Raffaele Marfella, Nunzia D'Onofrio, Celestino Sardu, Lucia Scisciola, Paolo Maggi, Nicola Coppola, Ciro Romano, Vincenzo Messina, Fabrizio Turriziani, Mario Siniscalchi, Mauro Maniscalco, Marco Boccalatte, Giovanni Napolitano, Luigi Salemme, Ludovica Vittoria Marfella, Eugenio Basile, Maria Vittoria Montemurro, Carmela Papa, Francesco Frascaria, Antonio Papa, Ferdinando Russo, Virginia Tirino, Gianpaolo Papaccio, Marilena Galdiero, Ferdinando Carlo Sasso, Michelangela Barbieri, Maria Rosaria Rizzo, Maria Luisa Balestrieri, Italo Francesco Angelillo, Claudio Napoli, Giuseppe Paolisso

Journal: Diabetes Obes Metab

PubMed ID: 34494705

Doi: 10.1111/dom.14547

Products & Services: Serology SARS-Cov-2 detection kits

Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

Products & Services: Molecular Biology Tools

Effect of Structural Changes Induced by Deletion of 54FLRAPSWF61 Sequence in αB-Crystallin on Chaperone Function and Anti-Apoptotic Activity

Authors: Sundararajan Mahalingam, Srabani Karmakar 1ORCID, Puttur Santhoshkumar, Krishna K. Sharma

Journal: International Journal of Molecular Sciences

PubMed ID: 34639110

Doi: 10.3390/ijms221910771

Products & Services: Proteins, Expression, Isolation and Analysis

Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells

Authors: Daria S Chulpanova, Zarema E Gilazieva, Elvira R Akhmetzyanova, Sevindzh K Kletukhina, Albert A Rizvanov, Valeriya V Solovyeva

Journal: Tissue Cell

PubMed ID: 34678531

Doi: 10.1016/j.tice.2021.101664

Products & Services: PCR Cloning and Subcloning

Quantitative comparison of different fluorescent dye-loaded nanoparticles

Authors: Guangze Yang, Yun Liu, Chun-Xia Zhao

Journal: Colloids Surf B Biointerfaces

PubMed ID: 34146992

Doi: doi.org/10.1016/j.colsurfb.2021.111923

Products & Services: Peptide Synthesis

Transgenic genome editing-derived antiviral therapy to nucleopolyhedrovirus infection in the industrial strain of the silkworm

Authors: Xu Yang, Xiaoqian Zhang, Yujia Liu, Dehong Yang, Zulian Liu, Kai Chen, Linmeng Tang, Manli Wang, Zhihong Hu, Shengxiang Zhang, Yongping Huang

Journal: Insect Biochem Mol Biol

PubMed ID: 34700022

Doi: 10.1016/j.ibmb.2021.103672

Products & Services: GenCrispr Cas9 Genome Editing

Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells

Authors: Chuanzhao Yu, Haiwen Zhong, Xiaohui Yang, Guoling Li, Zhenfang Wu, Huaqiang Yang

Journal: Biotechnol J

PubMed ID: 34705337

Doi: 10.1002/biot.202100408

Products & Services: PCR Cloning and Subcloning

Tong‑fu‑li‑fei decoction attenuates immunosuppression to protect the intestinal‑mucosal barrier in sepsis by inhibiting the PD‑1/PD‑L1 signaling pathway

Authors: Li Chen, Lan Li, Suzhao Zou, Qianhua Liao, Bo Lv

Journal: Mol Med Rep

PubMed ID: 34633052

Doi: 10.3892/mmr.2021.12480

Products & Services: Nucleic Acid Purification & Analysis

Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2

Authors: Ren-Lei Ji, Lu Huang, Yin Wang, Ting Liu, Si-Yu Fan, Min Tao, Ya-Xiong Tao

Journal: Endocr Connect

PubMed ID: 34678761

Doi: 10.1530/EC-21-0459

Products & Services: Nucleic Acid Purification & Analysis

Determining folding and binding properties of the C-terminal SH2 domain of SHP2

Authors: Caterina Nardella, Francesca Malagrinò, Livia Pagano, Serena Rinaldo, Stefano Gianni, Angelo Toto

Journal: Protein Sci

PubMed ID: 34605082

Doi: 10.1002/pro.4201

Products & Services: Mutagenesis Services

Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

Authors: Dong-Ho Jo, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Yu-Min Kang, Kang-Won Choe, Kwang-Nam Kim

Journal: Vaccines (Basel)

PubMed ID: 34696253

Doi: 10.3390/vaccines9101145

Products & Services: Mammalian Expression

Structural basis of cytokine-mediated activation of ALK family receptors

Authors: Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J Fernando Bazan, Akihide Yoshimi, Savvas N Savvides

Journal: Nature

PubMed ID: 34646012

Doi: 10.1038/s41586-021-03959-5

Products & Services: Mammalian Expression

Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients

Authors: Jonathan Marable, Damien Ruiz, Anil K Jaiswal, Ritankar Bhattacharya, Robert Pantazes, Payal Agarwal, Amol S Suryawanshi, Deepa Bedi, Amarjit Mishra, Bruce F Smith, Maninder Sandey

Journal: Sci Rep

PubMed ID: 34675296

Doi: 10.1038/s41598-021-00325-3

Products & Services: Endotoxin Detection & Removal System

The Small Metal-Binding Protein SmbP Simplifies the Recombinant Expression and Purification of the Antimicrobial Peptide LL-37

Authors: David A Perez-Perez, Teresa de J Villanueva-Ramirez, Adriana E Hernandez-Pedraza, Nestor G Casillas-Vega, Patricia Gonzalez-Barranco, Xristo Zarate

Journal: Antibiotics (Basel)

PubMed ID: 34680851

Doi: 10.3390/antibiotics10101271

Products & Services: DNA Sequencing Gene Synthesis

Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells

Authors: Yishan Ge, Wenwu Liu, Wei Yin, Xuebin Wang, Jie Wang, Xiaoqing Zhu, Shengkai Xu

Journal: Bioengineered

PubMed ID: 34637670

Doi: 10.1080/21655979.2021.1989260

Products & Services: DNA Sequencing

Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism

Authors: Edem Gavor, Yeu Khai Choong, Chacko Jobichen, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Protein Sci

PubMed ID: 34658092

Doi: 10.1002/pro.4212

Products & Services: Custom Vector Construction

ChimLeish, a new recombinant chimeric protein evaluated as a diagnostic and prognostic marker for visceral leishmaniasis and human immunodeficiency virus coinfection

Authors: Nathalia C Galvani, Amanda S Machado, Daniela P Lage, Camila S Freitas, Danniele L Vale, Daysiane de Oliveira, Fernanda Ludolf, Fernanda F Ramos, Bruna B Fernandes, Gabriel P Luiz, Débora V C Mendonça, João A Oliveira-da-Silva, Thiago A R Reis, Grasiele S V Tavares, Ana T Chaves, Nathalia S Guimarães, Unaí Tupinambás, Gláucia F Cota, Maria V Humbert, Vívian T Martins, Myron Christodoulides, Eduardo A F Coelho, Ricardo A Machado-de-Ávila

Journal: Parasitol Res

PubMed ID: 34664113

Doi: 10.1007/s00436-021-07342-1

Products & Services: Custom Vector Construction

Discovery of a novel glucuronan lyase system in

Authors: Bo Pilgaard, Marlene Vuillemin, Line Munk, Jesper Holck, Sebastian Meier, Casper Wilkens, Anne S Meyer

Journal: Appl Environ Microbiol

PubMed ID: 34705548

Doi: 10.1128/AEM.01819-21

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Analysis of IgG, IgA and IgM antibodies against SARS-CoV-2 spike protein S1 in convalescent and vaccinated patients with the Pfizer-BioNTech and CanSinoBio vaccines

Authors: Edgar A Melgoza-González, Diana Hinojosa-Trujillo, Mónica Reséndiz-Sandoval, Verónica Mata-Haro, Sofía Hernández-Valenzuela, Melissa García-Vega, Marlene Bravo-Parra, Aldo A Arvizu-Flores, Olivia Valenzuela, Edgar Velázquez, Alan Soto-Gaxiola, Martha B Gómez-Meza, Fernando Pérez-Jacobo, Luis Villela, Jesús Hernández

Journal: Transbound Emerg Dis

PubMed ID: 34655457

Doi: 10.1111/tbed.14344

Products & Services: Custom Vector Construction

Optimizing -Mediated Transformation and CRISPR-Cas9 Gene Editing in the Rice Variety Presidio

Authors: Marco Molina-Risco, Oneida Ibarra, Mayra Faion-Molina, Backki Kim, Endang M Septiningsih, Michael J Thomson

Journal: Int J Mol Sci

PubMed ID: 34681568

Doi: 10.3390/ijms222010909

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CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation

Authors: Xiaohan Mei, Xiao-Bing Cui, Yiran Li, Shi-You Chen

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34670409

Doi: 10.1161/ATVBAHA.121.316911

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A Novel Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase

Authors: Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Antonio Mattia Modarelli, Matteo Bertelli, Leonardo Colombo, Daniele Dell'Orco

Journal: Int J Mol Sci

PubMed ID: 34639157

Doi: 10.3390/ijms221910809

Products & Services: Custom Vector Construction Gene Synthesis

The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Zachary C Elmore, L Patrick Havlik, Daniel K Oh, Leif Anderson, George Daaboul, Garth W Devlin, Heather A Vincent, Aravind Asokan

Journal: Nat Commun

PubMed ID: 34716331

Doi: 10.1038/s41467-021-26485-4

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Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1

Authors: Yan Li, Elizabeth YiHui Ng, Ying Ru Loh, Chong Yu Gea, Qiwei Huang, Qingxin Li, CongBao Kang

Journal: J Pept Sci

PubMed ID: 34713534

Doi: 10.1002/psc.3376

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Advances in Universal CAR-T Cell Therapy

Authors: Haolong Lin, Jiali Cheng, Wei Mu, Jianfeng Zhou, Li Zhu

Journal: Front Immunol

PubMed ID: 34691052

Doi: 10.3389/fimmu.2021.744823

Products & Services: CRISPR Libraries

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Authors: Quanli Liu, Yi Liu, Gang Li, Otto Savolainen, Yun Chen, Jens Nielsen

Journal: Nat Commun

PubMed ID: 34667183

Doi: 10.1038/s41467-021-26361-1

Products & Services: Codon Optimization

CRISPR/Cas12a-assisted rapid identification of key beer spoilage bacteria

Authors: Qingzhou Menga, Hongmei Yangb, Guiquan Zhangc, Wenjun Sund, Peixiang Mae, Xinyi Liuf, Lu Dangg, Guanglei Lid, Xingxu Huangd, Xinjie Wangh, Jianghuai Liuc, Qibin Lenga

Journal: Innovative Food Science and Emerging Technologies

Doi: 10.1016/j.ifset.2021.102854

Products & Services: Synthetic sgRNA and crRNA Service

NIN-like protein transcription factors regulate leghemoglobin genes in legume nodules

Authors: Suyu Jiang, Marie-Françoise Jardinaud, Jinpeng Gao, Yann Pecrix, Jiangqi Wen,b Kirankumar Mysore, Ping Xu, Carmen Sanchez-Canizares, Yiting Ruan, Qiujiu Li, Meijun Zhu, Fuyu Li, Ertao Wang, Phillip S Poole, Pascal Gamas, Jeremy D Murray

Journal: Science

PubMed ID: 34709882

Doi: 10.1126/science.abg5945

Products & Services: Gene Synthesis

An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein

Authors: Narasimha Anaganti, Sujith Rajan, M Mahmood Hussain

Journal: J Lipid Res

PubMed ID: 34673018

Doi: 10.1016/j.jlr.2021.100136

Products & Services: Peptide Synthesis

Construction and Analysis of a Yeast for the Simultaneous Release and Esterification of the Varietal Thiol 3-Sulfanylhexan-1-ol

Authors: Florian Kiene, Isak S Pretorius, Doris Rauhut, Christian von Wallbrunn, Niël van Wyk

Journal: J Agric Food Chem

PubMed ID: 34609136

Doi: 10.1021/acs.jafc.1c03976

Products & Services: Synthetic sgRNA and crRNA Service

Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma

Authors: Sakiko Harada, Miki Ando, Jun Ando, Midori Ishii, Tomoyuki Yamaguchi, Satoshi Yamazaki, Tokuko Toyota, Kazuo Ohara, Manami Ohtaka, Mahito Nakanishi, Chansu Shin, Yasunori Ota, Kazutaka Nakashima, Koichi Ohshima, Chihaya Imai, Yozo Nakazawa, Hiromitsu Nakauchi, Norio Komatsu

Journal: Mol Ther

PubMed ID: 34628050

Doi: 10.1016/j.ymthe.2021.10.006

Products & Services: Recombinant Antibody Expression

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

Authors: Matthias Liniger, Markus Gerber, Sandra Renzullo, Obdulio García-Nicolás, Nicolas Ruggli

Journal: Viruses

PubMed ID: 34696447

Doi: 10.3390/v13102017

Products & Services: Proteins, Expression, Isolation and Analysis

Corrigendum to "Rapid preparation of nanodiscs for biophysical studies" [Arch Biochem Biophys 712 (2021) 109051]

Authors: Jeffrey A Julien, Martin G Fernandez, Katrina M Brandmier, Joshua T Del Mundo, Carol M Bator, Lucie A Loftus, Esther W Gomez, Enrique D Gomez, Kerney Jebrell Glover

Journal: Arch Biochem Biophys

PubMed ID: 34756727

Doi: 10.1016/j.abb.2021.109073

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

Authors: Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang

Journal: J Med Chem

PubMed ID: 34668699

Doi: 10.1021/acs.jmedchem.1c01076

Products & Services: Proteins, Expression, Isolation and Analysis

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Authors: Shuang-Zhou Peng, Xiao-Hui Chen, Si-Jie Chen, Jie Zhang, Chuan-Ying Wang, Wei-Rong Liu, Duo Zhang, Ying Su, Xiao-Kun Zhang

Journal: Nat Commun

PubMed ID: 34645818

Doi: 10.1038/s41467-021-26295-8

Products & Services: Proteins, Expression, Isolation and Analysis

Evidence of a shared binding site for Bacillus thuringiensis Cry1Ac and Cry2Aa toxins in Cnaphalocrocis medinalis cadherin

Authors: J Zhong, S Fang, M Gao, L Lu, X Zhang, Q Zhu, Y Liu, J L Jurat-Fuentes, X Liu

Journal: Insect Mol Biol

PubMed ID: 34637177

Doi: 10.1111/imb.12741

Products & Services: Proteins, Expression, Isolation and Analysis

Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways

Authors: Sean T Carey, Joshua M Gammon, Christopher M Jewell

Journal: Drug Deliv Transl Res

PubMed ID: 34611846

Doi: 10.1007/s13346-021-01075-5

Products & Services: Proteins, Expression, Isolation and Analysis

Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine

Authors: Danielle L Porier, Sarah N Wilson, Dawn I Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C Allen, Clayton C Caswell, James A Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C Weaver, Albert J Auguste

Journal: Vaccines (Basel)

PubMed ID: 34696250

Doi: 10.3390/vaccines9101142

Products & Services: Plasmid DNA Preparation

L-asparaginase from : expression, purification and cytotoxicity assessment

Authors: Hesham Saeed, Eman Elsawy, Manal Shalaby, Manal Abdel-Fattah, Asmaa Hemida, Ahmad Eldoksh, Farid Shokry Ataya, Hesham Nematalla, Mohamed Elkewedi, Nikolaos N Labrou, Nefertiti El-Nikhely

Journal: Prep Biochem Biotechnol

PubMed ID: 34612174

Doi: 10.1080/10826068.2021.1983831

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Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation

Authors: Patrick N Charron, Luis M Garcia, Irfan Tahir, Rachael A Floreani

Journal: J Mech Behav Biomed Mater

PubMed ID: 34736027

Doi: 10.1016/j.jmbbm.2021.104932

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A Novel Antimicrobial Peptide Sparamosin From the Mud Crab Showing Potent Antifungal Activity Against

Authors: Yan-Chao Chen, Ying Yang, Chang Zhang, Hui-Yun Chen, Fangyi Chen, Ke-Jian Wang

Journal: Front Microbiol

PubMed ID: 34690992

Doi: 10.3389/fmicb.2021.746006

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Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Authors: Xueyin Wang, Mark L Sandberg, Aaron D Martin, Kathleen R Negri, Grant B Gabrelow, Daniel P Nampe, Ming-Lun Wu, Michele E McElvain, Dora Toledo Warshaviak, Wen-Hua Lee, Julyun Oh, Mark E Daris, Falene Chai, Christine Yao, James Furney, Craig Pigott, Alexander Kamb, Han Xu

Journal: J Immunother

PubMed ID: 34432728

Doi: 10.1097/CJI.0000000000000386

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Marked Increase in Tumor Transfection with a Truncated Branched Polymer

Authors: Songhui Xu, Jiaxi He, Zuha Imtiyaz, Atul K Agrawal, Martin C Woodle, A James Mixson

Journal: J Gene Med

PubMed ID: 34713552

Doi: 10.1002/jgm.3396

Products & Services: Peptide Synthesis

Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica

Authors: Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra

Journal: Insect Biochem Mol Biol

PubMed ID: 34656795

Doi: 10.1016/j.ibmb.2021.103671

Products & Services: Codon Optimization

Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor

Authors: David Sybers, Amber Joka Bernauw, Diala El Masri, Hassan Ramadan Maklad, Daniel Charlier, Marjan De Mey, Indra Bervoets, Eveline Peeters

Journal: Gene

PubMed ID: 34688814

Doi: 10.1016/j.gene.2021.146010

Products & Services: Codon Optimization

Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8 T-Cell Responses

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Wei-Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D Long, Fumito Ito, Scott I Abrams, Jonathan F Lovell

Journal: Adv Sci (Weinh)

PubMed ID: 34716694

Doi: 10.1002/advs.202103023

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Tuning Gene Expression by Phosphate in the Methanogenic Archaeon

Authors: Taiwo S Akinyemi, Nana Shao, Zhe Lyu, Ian J Drake, Yuchen Liu, William B Whitman

Journal: ACS Synth Biol

PubMed ID: 34665610

Doi: 10.1021/acssynbio.1c00322

Products & Services: Bacterial Expression

An Engineered Thermostable Laccase with Great Ability to Decolorize and Detoxify Malachite Green

Authors: Guotao Mao, Kai Wang, Fangyuan Wang, Hao Li, Hongsen Zhang, Hui Xie, Zhimin Wang, Fengqin Wang, Andong Song

Journal: Int J Mol Sci

PubMed ID: 34769185

Doi: 10.3390/ijms222111755

Products & Services: Gene Synthesis

Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

Authors: Mei Yang, Jiaqi Li, Zhaoxia Huang, Heng Li, Yueming Wang, Xiaoli Wang, Sisi Kang, Xing Huang, Changwen Wu, Tong Liu, Zhenxing Jia, Junlang Liang, Xiaohui Yuan, Suhua He, Xiaoxue Chen, Zhechong Zhou, Qiuyue Chen, Siqi Liu, Jing Li, Huiwen Zheng, Xi Liu, Kenan Li, Xiaojun Yao, Bin Lang, Longding Liu, Hua-Xin Liao, Shoudeng Chen

Journal: Microbiol Spectr

PubMed ID: 34643438

Doi: 10.1128/Spectrum.01352-21

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Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA

Authors: Anders Kokkenborg Varming, Kim Krighaar Rasmussen, Zhiyou Zong, Peter Waaben Thulstrup, Mogens Kilstrup, Leila Lo Leggio

Journal: FEBS J

PubMed ID: 34665941

Doi: 10.1111/febs.16238

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Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis Inhibition of AOC

Authors: Yumei Rong, Ge Hong, Na Zhu, Yang Liu, Yong Jiang, Tianjun Liu

Journal: Front Pharmacol

PubMed ID: 34744725

Doi: 10.3389/fphar.2021.746725

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Human antibody recognition of H7N9 influenza virus HA following natural infection

Authors: Iuliia M Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G Bombardi, Andrew Trivette, Sheng Li, Hannah L Turner, Robert H Carnahan, Andrew B Ward, James E Crowe

Journal: JCI Insight

PubMed ID: 34437301

Doi: 10.1172/jci.insight.152403

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Molecular Characterization of AMPA-Receptor-Containing Vesicles

Authors: John Jacob Peters, Jeremy Leitz, Juan A Oses-Prieto, Alma L Burlingame, Axel T Brunger

Journal: Front Mol Neurosci

PubMed ID: 34720876

Doi: 10.3389/fnmol.2021.754631

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Inhibition of receptor-binding domain-ACE2 interaction after two doses of Sinovac's CoronaVac or AstraZeneca/Oxford's AZD1222 SARS-CoV-2 vaccines

Authors: Valéria O Silva, Rosemeire Yamashiro, Cintia M Ahagon, Ivana B de Campos, Isabela P de Oliveira, Elaine L de Oliveira, Giselle I S López-Lopes, Elaine M Matsuda, Marcia J Castejon, Luís F de Macedo Brígido

Journal: J Med Virol

PubMed ID: 34647623

Doi: 10.1002/jmv.27396

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Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma

Authors: Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T Flaherty, Lee Zou, Hensin Tsao

Journal: J Invest Dermatol

PubMed ID: 34687746

Doi: 10.1016/j.jid.2021.07.188

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Authors: Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K Maini, Graham Ogg, Julian C Knight, Yanchun Peng, Sarah L Rowland-Jones, Tao Dong

Journal: iScience

PubMed ID: 34729465

Doi: 10.1016/j.isci.2021.103353

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miR-301a-5p Regulates during Chicken Spermatogenesis

Authors: Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

Journal: Genes (Basel)

PubMed ID: 34828300

Doi: 10.3390/genes12111695

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Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

Authors: Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H Stoffel, Fabien Labroussaa, Joerg Jores

Journal: PLoS Genet

PubMed ID: 34673769

Doi: 10.1371/journal.pgen.1009365

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Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

Authors: Sabrina Lusvarghi, Wei Wang, Rachel Herrup, Sabari Nath Neerukonda, Russell Vassell, Lisa Bentley, Ann E Eakin, Karl J Erlandson, Carol D Weiss

Journal: J Virol

PubMed ID: 34668774

Doi: 10.1128/JVI.01110-21

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The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D Weissman, Amit K Singh, Ballachanda N Devaiah, Peter Schuck, Ross C LaRue, Dinah S Singer

Journal: J Biol Chem

PubMed ID: 34688663

Doi: 10.1016/j.jbc.2021.101326

Products & Services: Proteins, Expression, Isolation and Analysis

The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization

Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders

Journal: J Virol

PubMed ID: 34669426

Doi: 10.1128/JVI.01552-21

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

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A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis

Authors: Scott Latimer, Shea A Keene, Lauren R Stutts, Antoine Berger, Ann C Bernert, Eric Soubeyrand, Janet Wright, Catherine F Clarke, Anna K Block, Thomas A Colquhoun, Christian Elowsky, Alan Christensen, Mark A Wilson, Gilles J Basset

Journal: J Biol Chem

PubMed ID: 34626646

Doi: 10.1016/j.jbc.2021.101283

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Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Authors: Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Journal: Res Pharm Sci

PubMed ID: 34760006

Doi: 10.4103/1735-5362.327504

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Bright and stable luminescent probes for target engagement profiling in live cells

Authors: N Connor Payne, Alena S Kalyakina, Kritika Singh, Mark A Tye, Ralph Mazitschek

Journal: Nat Chem Biol

PubMed ID: 34675420

Doi: 10.1038/s41589-021-00877-5

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Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA

Authors: Xin Duan, Lei Cai, Christine T N Pham, Yousef Abu-Amer, Hua Pan, Robert H Brophy, Samuel A Wickline, Muhammad Farooq Rai

Journal: Arthritis Rheumatol

PubMed ID: 33982891

Doi: 10.1002/art.41794

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Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Authors: Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W Mellors, Steven D Shapiro, Dimiter S Dimitrov

Journal: Int J Mol Sci

PubMed ID: 34681796

Doi: 10.3390/ijms222011136

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Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Authors: Chao Wu, Abraham J Qavi, Austin B Moyle, Nicole D Wagner, Asmaa Hachim, Niloufar Kavian, Aidan R Cole, Joyce Sweeney-Gibbons, Henry W Rohrs, J S Malik Peiris, Christopher F Basler, Michael L Gross, Sophie A Valkenburg, Christopher W Farnsworth, Gaya K Amarasinghe, Daisy W Leung

Journal: STAR Protoc

PubMed ID: 34642671

Doi: 10.1016/j.xpro.2021.100906

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Protective effect of sargahydroquinoic acid against Aβ-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

Authors: Jeong-Hyun Yoon, Kumju Youn, Mira Jun

Journal: Biomed Pharmacother

PubMed ID: 34619494

Doi: 10.1016/j.biopha.2021.112271

Products & Services: Proteins, Expression, Isolation and Analysis

Systemic autoimmune myopathies: A prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2

Authors: Samuel K Shinjo, Fernando H C de Souza, Isabela B P Borges, Alexandre M Dos Santos, Renata Miossi, Rafael G Misse, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuki, Sandra G Pasoto, Léonard V K Kupa, Carina Ceneviva, Júlia C Seraphim, Tatiana N Pedrosa, Margarete B G Vendramini, Clóvis A Silva, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34664616

Doi: 10.1093/rheumatology/keab773

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Biochemical and structural studies of two tetrameric nucleoside 2'-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Authors: Jesús Fernández-Lucas, Iván Acebrón, Ruiying Y Wu, Yohana Alfaro, Javier Acosta, Pierre A Kaminski, Miguel Arroyo, Andrzej Joachimiak, Boguslaw P Nocek, Isabel De la Mata, José M Mancheño

Journal: Int J Biol Macromol

PubMed ID: 34624379

Doi: 10.1016/j.ijbiomac.2021.09.164

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The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son, Jeon-Soo Shin

Journal: Mol Med

PubMed ID: 34602056

Doi: 10.1186/s10020-021-00388-y

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The Slower Antibody Response in Myelofibrosis Patients after Two Doses of mRNA SARS-CoV-2 Vaccine Calls for a Third Dose

Authors: Fabio Fiorino, Anna Sicuranza, Annalisa Ciabattini, Adele Santoni, Gabiria Pastore, Martina Simoncelli, Jacopo Polvere, Sara Galimberti, Stefano Auddino, Claudia Baratè, Francesca Montagnani, Vincenzo Sammartano, Monica Bocchia, Donata Medaglini

Journal: Biomedicines

PubMed ID: 34680595

Doi: 10.3390/biomedicines9101480

Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

Authors: J S T Zee, K T W Lai, M K S Ho, A C P Leung, L H Fung, W P Luk, L F Kwok, K M Kee, Q W L Chan, S F Tang, E S K Ma, K H Lee, C C Lau, R W H Yung

Journal: Hong Kong Med J

PubMed ID: 34657837

Doi: 10.12809/hkmj219744

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Authors: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B Goodman

Journal: Bioengineering (Basel)

PubMed ID: 34821731

Doi: 10.3390/bioengineering8110165

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8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Authors: Tamás Pivarcsik, Orsolya Dömötör, János P Mészáros, Nóra V May, Gabriella Spengler, Oszkár Csuvik, István Szatmári, Éva A Enyedy

Journal: Int J Mol Sci

PubMed ID: 34681939

Doi: 10.3390/ijms222011281

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Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective

Authors: Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky

Journal: Bioanalysis

PubMed ID: 34645288

Doi: 10.4155/bio-2021-0096

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Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Authors: Hsi-En Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles

Journal: JCI Insight

PubMed ID: 34622805

Doi: 10.1172/jci.insight.144777

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Self-inhibitory peptides targeting the MtrCDE efflux pump increase antibiotic susceptibility

Authors: Benjamin J Evert, Valentin A Slesarenko, Jilsy M J Punnasseril, Jian Zhan, Yaoqi Zhou, Evgeny A Semchenko, Kate L Seib

Journal: Antimicrob Agents Chemother

PubMed ID: 34633841

Doi: 10.1128/AAC.01542-21

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High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1

Authors: Anja Bernhardt, Saskia Häberer, JingJing Xu, Hannah Damerau, Johannes Steffen, Charlotte Reichardt, Katharina Wolters, Hannes Steffen, Berend Isermann, Katrin Borucki, Nadine Artelt, Nicole Endlich, Renata Kozyraki, Sabine Brandt, Jonathan A Lindquist, Peter R Mertens

Journal: FASEB J

PubMed ID: 34533842

Doi: 10.1096/fj.202100667RR

Products & Services: Proteins, Expression, Isolation and Analysis

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Authors: Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 34643433

Doi: 10.1128/JVI.01340-21

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