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A Novel Antimicrobial Peptide Sparamosin From the Mud Crab Showing Potent Antifungal Activity Against

Authors: Yan-Chao Chen, Ying Yang, Chang Zhang, Hui-Yun Chen, Fangyi Chen, Ke-Jian Wang

Journal: Front Microbiol

PubMed ID: 34690992

Doi: 10.3389/fmicb.2021.746006

Products & Services: Peptide Synthesis

Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Authors: Xueyin Wang, Mark L Sandberg, Aaron D Martin, Kathleen R Negri, Grant B Gabrelow, Daniel P Nampe, Ming-Lun Wu, Michele E McElvain, Dora Toledo Warshaviak, Wen-Hua Lee, Julyun Oh, Mark E Daris, Falene Chai, Christine Yao, James Furney, Craig Pigott, Alexander Kamb, Han Xu

Journal: J Immunother

PubMed ID: 34432728

Doi: 10.1097/CJI.0000000000000386

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Marked Increase in Tumor Transfection with a Truncated Branched Polymer

Authors: Songhui Xu, Jiaxi He, Zuha Imtiyaz, Atul K Agrawal, Martin C Woodle, A James Mixson

Journal: J Gene Med

PubMed ID: 34713552

Doi: 10.1002/jgm.3396

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Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica

Authors: Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra

Journal: Insect Biochem Mol Biol

PubMed ID: 34656795

Doi: 10.1016/j.ibmb.2021.103671

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Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor

Authors: David Sybers, Amber Joka Bernauw, Diala El Masri, Hassan Ramadan Maklad, Daniel Charlier, Marjan De Mey, Indra Bervoets, Eveline Peeters

Journal: Gene

PubMed ID: 34688814

Doi: 10.1016/j.gene.2021.146010

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Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8 T-Cell Responses

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Wei-Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D Long, Fumito Ito, Scott I Abrams, Jonathan F Lovell

Journal: Adv Sci (Weinh)

PubMed ID: 34716694

Doi: 10.1002/advs.202103023

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Tuning Gene Expression by Phosphate in the Methanogenic Archaeon

Authors: Taiwo S Akinyemi, Nana Shao, Zhe Lyu, Ian J Drake, Yuchen Liu, William B Whitman

Journal: ACS Synth Biol

PubMed ID: 34665610

Doi: 10.1021/acssynbio.1c00322

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An Engineered Thermostable Laccase with Great Ability to Decolorize and Detoxify Malachite Green

Authors: Guotao Mao, Kai Wang, Fangyuan Wang, Hao Li, Hongsen Zhang, Hui Xie, Zhimin Wang, Fengqin Wang, Andong Song

Journal: Int J Mol Sci

PubMed ID: 34769185

Doi: 10.3390/ijms222111755

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Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

Authors: Mei Yang, Jiaqi Li, Zhaoxia Huang, Heng Li, Yueming Wang, Xiaoli Wang, Sisi Kang, Xing Huang, Changwen Wu, Tong Liu, Zhenxing Jia, Junlang Liang, Xiaohui Yuan, Suhua He, Xiaoxue Chen, Zhechong Zhou, Qiuyue Chen, Siqi Liu, Jing Li, Huiwen Zheng, Xi Liu, Kenan Li, Xiaojun Yao, Bin Lang, Longding Liu, Hua-Xin Liao, Shoudeng Chen

Journal: Microbiol Spectr

PubMed ID: 34643438

Doi: 10.1128/Spectrum.01352-21

Products & Services: Recombinant Proteins

Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA

Authors: Anders Kokkenborg Varming, Kim Krighaar Rasmussen, Zhiyou Zong, Peter Waaben Thulstrup, Mogens Kilstrup, Leila Lo Leggio

Journal: FEBS J

PubMed ID: 34665941

Doi: 10.1111/febs.16238

Products & Services: Recombinant Proteins

Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis Inhibition of AOC

Authors: Yumei Rong, Ge Hong, Na Zhu, Yang Liu, Yong Jiang, Tianjun Liu

Journal: Front Pharmacol

PubMed ID: 34744725

Doi: 10.3389/fphar.2021.746725

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Human antibody recognition of H7N9 influenza virus HA following natural infection

Authors: Iuliia M Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G Bombardi, Andrew Trivette, Sheng Li, Hannah L Turner, Robert H Carnahan, Andrew B Ward, James E Crowe

Journal: JCI Insight

PubMed ID: 34437301

Doi: 10.1172/jci.insight.152403

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Molecular Characterization of AMPA-Receptor-Containing Vesicles

Authors: John Jacob Peters, Jeremy Leitz, Juan A Oses-Prieto, Alma L Burlingame, Axel T Brunger

Journal: Front Mol Neurosci

PubMed ID: 34720876

Doi: 10.3389/fnmol.2021.754631

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Inhibition of receptor-binding domain-ACE2 interaction after two doses of Sinovac's CoronaVac or AstraZeneca/Oxford's AZD1222 SARS-CoV-2 vaccines

Authors: Valéria O Silva, Rosemeire Yamashiro, Cintia M Ahagon, Ivana B de Campos, Isabela P de Oliveira, Elaine L de Oliveira, Giselle I S López-Lopes, Elaine M Matsuda, Marcia J Castejon, Luís F de Macedo Brígido

Journal: J Med Virol

PubMed ID: 34647623

Doi: 10.1002/jmv.27396

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Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma

Authors: Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T Flaherty, Lee Zou, Hensin Tsao

Journal: J Invest Dermatol

PubMed ID: 34687746

Doi: 10.1016/j.jid.2021.07.188

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Authors: Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K Maini, Graham Ogg, Julian C Knight, Yanchun Peng, Sarah L Rowland-Jones, Tao Dong

Journal: iScience

PubMed ID: 34729465

Doi: 10.1016/j.isci.2021.103353

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miR-301a-5p Regulates during Chicken Spermatogenesis

Authors: Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

Journal: Genes (Basel)

PubMed ID: 34828300

Doi: 10.3390/genes12111695

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Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

Authors: Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H Stoffel, Fabien Labroussaa, Joerg Jores

Journal: PLoS Genet

PubMed ID: 34673769

Doi: 10.1371/journal.pgen.1009365

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Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

Authors: Sabrina Lusvarghi, Wei Wang, Rachel Herrup, Sabari Nath Neerukonda, Russell Vassell, Lisa Bentley, Ann E Eakin, Karl J Erlandson, Carol D Weiss

Journal: J Virol

PubMed ID: 34668774

Doi: 10.1128/JVI.01110-21

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The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D Weissman, Amit K Singh, Ballachanda N Devaiah, Peter Schuck, Ross C LaRue, Dinah S Singer

Journal: J Biol Chem

PubMed ID: 34688663

Doi: 10.1016/j.jbc.2021.101326

Products & Services: Proteins, Expression, Isolation and Analysis

The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization

Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders

Journal: J Virol

PubMed ID: 34669426

Doi: 10.1128/JVI.01552-21

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis

Authors: Scott Latimer, Shea A Keene, Lauren R Stutts, Antoine Berger, Ann C Bernert, Eric Soubeyrand, Janet Wright, Catherine F Clarke, Anna K Block, Thomas A Colquhoun, Christian Elowsky, Alan Christensen, Mark A Wilson, Gilles J Basset

Journal: J Biol Chem

PubMed ID: 34626646

Doi: 10.1016/j.jbc.2021.101283

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Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Authors: Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Journal: Res Pharm Sci

PubMed ID: 34760006

Doi: 10.4103/1735-5362.327504

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Bright and stable luminescent probes for target engagement profiling in live cells

Authors: N Connor Payne, Alena S Kalyakina, Kritika Singh, Mark A Tye, Ralph Mazitschek

Journal: Nat Chem Biol

PubMed ID: 34675420

Doi: 10.1038/s41589-021-00877-5

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Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA

Authors: Xin Duan, Lei Cai, Christine T N Pham, Yousef Abu-Amer, Hua Pan, Robert H Brophy, Samuel A Wickline, Muhammad Farooq Rai

Journal: Arthritis Rheumatol

PubMed ID: 33982891

Doi: 10.1002/art.41794

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Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Authors: Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W Mellors, Steven D Shapiro, Dimiter S Dimitrov

Journal: Int J Mol Sci

PubMed ID: 34681796

Doi: 10.3390/ijms222011136

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Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Authors: Chao Wu, Abraham J Qavi, Austin B Moyle, Nicole D Wagner, Asmaa Hachim, Niloufar Kavian, Aidan R Cole, Joyce Sweeney-Gibbons, Henry W Rohrs, J S Malik Peiris, Christopher F Basler, Michael L Gross, Sophie A Valkenburg, Christopher W Farnsworth, Gaya K Amarasinghe, Daisy W Leung

Journal: STAR Protoc

PubMed ID: 34642671

Doi: 10.1016/j.xpro.2021.100906

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Protective effect of sargahydroquinoic acid against Aβ-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

Authors: Jeong-Hyun Yoon, Kumju Youn, Mira Jun

Journal: Biomed Pharmacother

PubMed ID: 34619494

Doi: 10.1016/j.biopha.2021.112271

Products & Services: Proteins, Expression, Isolation and Analysis

Systemic autoimmune myopathies: A prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2

Authors: Samuel K Shinjo, Fernando H C de Souza, Isabela B P Borges, Alexandre M Dos Santos, Renata Miossi, Rafael G Misse, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuki, Sandra G Pasoto, Léonard V K Kupa, Carina Ceneviva, Júlia C Seraphim, Tatiana N Pedrosa, Margarete B G Vendramini, Clóvis A Silva, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34664616

Doi: 10.1093/rheumatology/keab773

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Biochemical and structural studies of two tetrameric nucleoside 2'-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Authors: Jesús Fernández-Lucas, Iván Acebrón, Ruiying Y Wu, Yohana Alfaro, Javier Acosta, Pierre A Kaminski, Miguel Arroyo, Andrzej Joachimiak, Boguslaw P Nocek, Isabel De la Mata, José M Mancheño

Journal: Int J Biol Macromol

PubMed ID: 34624379

Doi: 10.1016/j.ijbiomac.2021.09.164

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The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son, Jeon-Soo Shin

Journal: Mol Med

PubMed ID: 34602056

Doi: 10.1186/s10020-021-00388-y

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The Slower Antibody Response in Myelofibrosis Patients after Two Doses of mRNA SARS-CoV-2 Vaccine Calls for a Third Dose

Authors: Fabio Fiorino, Anna Sicuranza, Annalisa Ciabattini, Adele Santoni, Gabiria Pastore, Martina Simoncelli, Jacopo Polvere, Sara Galimberti, Stefano Auddino, Claudia Baratè, Francesca Montagnani, Vincenzo Sammartano, Monica Bocchia, Donata Medaglini

Journal: Biomedicines

PubMed ID: 34680595

Doi: 10.3390/biomedicines9101480

Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

Authors: J S T Zee, K T W Lai, M K S Ho, A C P Leung, L H Fung, W P Luk, L F Kwok, K M Kee, Q W L Chan, S F Tang, E S K Ma, K H Lee, C C Lau, R W H Yung

Journal: Hong Kong Med J

PubMed ID: 34657837

Doi: 10.12809/hkmj219744

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Authors: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B Goodman

Journal: Bioengineering (Basel)

PubMed ID: 34821731

Doi: 10.3390/bioengineering8110165

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8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Authors: Tamás Pivarcsik, Orsolya Dömötör, János P Mészáros, Nóra V May, Gabriella Spengler, Oszkár Csuvik, István Szatmári, Éva A Enyedy

Journal: Int J Mol Sci

PubMed ID: 34681939

Doi: 10.3390/ijms222011281

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Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective

Authors: Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky

Journal: Bioanalysis

PubMed ID: 34645288

Doi: 10.4155/bio-2021-0096

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Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Authors: Hsi-En Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles

Journal: JCI Insight

PubMed ID: 34622805

Doi: 10.1172/jci.insight.144777

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Self-inhibitory peptides targeting the MtrCDE efflux pump increase antibiotic susceptibility

Authors: Benjamin J Evert, Valentin A Slesarenko, Jilsy M J Punnasseril, Jian Zhan, Yaoqi Zhou, Evgeny A Semchenko, Kate L Seib

Journal: Antimicrob Agents Chemother

PubMed ID: 34633841

Doi: 10.1128/AAC.01542-21

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High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1

Authors: Anja Bernhardt, Saskia Häberer, JingJing Xu, Hannah Damerau, Johannes Steffen, Charlotte Reichardt, Katharina Wolters, Hannes Steffen, Berend Isermann, Katrin Borucki, Nadine Artelt, Nicole Endlich, Renata Kozyraki, Sabine Brandt, Jonathan A Lindquist, Peter R Mertens

Journal: FASEB J

PubMed ID: 34533842

Doi: 10.1096/fj.202100667RR

Products & Services: Proteins, Expression, Isolation and Analysis

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Authors: Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 34643433

Doi: 10.1128/JVI.01340-21

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A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Authors: Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou

Journal: Cell Rep Med

PubMed ID: 34723223

Doi: 10.1016/j.xcrm.2021.100448

Products & Services: Proteins, Expression, Isolation and Analysis

Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells

Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang, Jiao Jiao

Journal: BMC Cancer

PubMed ID: 34620126

Doi: 10.1186/s12885-021-08779-4

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A New Hybrid Protein Is a Novel Regulator for Experimental Colitis in Rats

Authors: Kohki Okada, Masaki Ikemoto

Journal: Inflammation

PubMed ID: 34628574

Doi: 10.1007/s10753-021-01537-5

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile

Authors: Jeba R J Jesudoss Chelladurai, Douglas E Jones, Matthew T Brewer

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 34753107

Doi: 10.1016/j.ijpddr.2021.10.002

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Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

Authors: Xia Bu, Vikram R Juneja, Carol G Reynolds, Kathleen M Mahoney, Melissa T Bu, Kathleen A McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward A Greenfield, Philippe Armand, Jerome Ritz, Arlene H Sharpe, Gordon J Freeman

Journal: Cancer Immunol Res

PubMed ID: 34635486

Doi: 10.1158/2326-6066.CIR-21-0493

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Enhanced bone regeneration via spatiotemporal and controlled delivery ofa genetically engineered BMP-2 in a composite Hydrogel

Authors: Xin Chen , Baoyu Tan , Zhiteng Bao , Shang Wang , Rongze Tang , Zhenmin Wang , Gaoyang Chen , Shuai Chen , William W Lu , Dazhi Yang , Songlin Peng

Journal: Biomaterials

PubMed ID: 34517277

Doi: doi.org/10.1016/j.biomaterials.2021.121117

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Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

Authors: Prateek Kumar, ProfileTaniya Bhardwaj, ProfileRajanish Giri

Journal: biorxiv

Doi: doi.org/10.1101/2021.09.14.460211

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Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal integration

Authors: Siqi Yang, Yiwen Zhang, Jiaqi Xu, Jiao Zhang, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang

Journal: Nucleic Acids Res

PubMed ID: 34478496

Doi: 10.1093/nar/gkab752

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Regulation of human mTOR complexes by DEPTOR

Authors: Matthias Wälchli, Karolin Berneiser, Francesca Mangia, Stefan Imseng, Louise-Marie Craigie, Edward Stuttfeld, Michael N Hall, Timm Maier

Journal: Elife

PubMed ID: 34519268

Doi: 10.7554/eLife.70871

Products & Services: Proteins, Expression, Isolation and Analysis

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: medrxiv

PubMed ID: 34611671

Doi: 10.1101/2021.09.27.21264000

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Analytical and clinical performance of cPass neutralizing antibodies assay

Authors: Joanna Jung, Deepthi Rajapakshe, Christopher Julien, Sridevi Devaraj

Journal: Clin Biochem

PubMed ID: 34560062

Doi: 10.1016/j.clinbiochem.2021.09.008

Products & Services: Proteins, Expression, Isolation and Analysis

Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling

Authors: Vindya Ramanayake-Mudiyanselage, D Maheeka Embogama, Mary Kay H Pflum

Journal: J Proteome Res

PubMed ID: 34491762

Doi: 10.1021/acs.jproteome.1c00562

Products & Services: Proteins, Expression, Isolation and Analysis

A Small Cysteine-Rich Phytotoxic Protein of Functions as Both Plant Defense Elicitor and Virulence Factor

Authors: Zi-Hui Zhang, Jing-Hao Jin, Gui-Lin Sheng, Yu-Ping Xing, Wang Liu, Xue Zhou, Yi-Qing Liu, Xiao-Ren Chen

Journal: Mol Plant Microbe Interact

PubMed ID: 33819070

Doi: 10.1094/MPMI-01-21-0025-R

Products & Services: Proteins, Expression, Isolation and Analysis

A Closer Look into FDA-EUA Approved Diagnostic Techniques of Covid-19

Authors: Hyunju Oh, Hyunjeong Ahn, Anubhav Tripathi

Journal: ACS Infect Dis

PubMed ID: 34569778

Doi: 10.1021/acsinfecdis.1c00268

Products & Services: Proteins, Expression, Isolation and Analysis

Consumption of gossypol increases fatty acid-amino acid conjugates in the cotton pests Helicoverpa armigera and Heliothis virescens

Authors: Corinna Krempl, Nicole Joußen, Michael Reichelt, Marco Kai, Heiko Vogel, David G Heckel

Journal: Arch Insect Biochem Physiol

PubMed ID: 34490676

Doi: 10.1002/arch.21843

Products & Services: Proteins, Expression, Isolation and Analysis

The PshX subunit of the photochemical reaction center from Heliobacterium modesticaldum acts as a low-energy antenna

Authors: Gregory S Orf, Christopher J Gisriel, Jesse Granstrom, Patricia L Baker, Kevin E Redding

Journal: Photosynth Res

PubMed ID: 34480322

Doi: 10.1007/s11120-021-00871-x

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Development of a nanobody-based competitive ELISA for efficiently and specifically detecting antibodies against genotype 2 porcine reproductive and respiratory syndrome viruses

Authors: Hong Duan, Xu Chen, Jiakai Zhao, Jiahong Zhu, Guixi Zhang, Mengnan Fan, Beibei Zhang, Xueting Wang, Yani Sun, Baoyuan Liu, En-Min Zhou, Qin Zhao

Journal: J Clin Microbiol

PubMed ID: 34524888

Doi: 10.1128/JCM.01580-21

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The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Authors: Lung-Yu Liang, Michael Roy, Christopher R Horne, Jarrod J Sandow, Minglyanna Surudoi, Laura F Dagley, Samuel N Young, Toby Dite, Jeffrey J Babon, Peter W Janes, Onisha Patel, James M Murphy, Isabelle S Lucet

Journal: Biochem J

PubMed ID: 34431498

Doi: 10.1042/BCJ20210572

Products & Services: DNA Sequencing

Genic male sterility increases rice drought tolerance

Authors: Jianyu Wen, Yafei Zeng, Yunping Chen, Fengfeng Fan, Shaoqing Li

Journal: Plant Sci

PubMed ID: 34620451

Doi: 10.1016/j.plantsci.2021.111057

Products & Services: Custom Vector Construction

Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69

Authors: Jonas Persson, Emmi Puuvuori, Bo Zhang, Irina Velikyan, Ola Åberg, Malin Müller, Per-Åke Nygren, Stefan Ståhl, Olle Korsgren, Olof Eriksson, John Löfblom

Journal: Sci Rep

PubMed ID: 34580321

Doi: 10.1038/s41598-021-97694-6

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Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Authors: Tingting Li, Wenhui Xue, Qingbing Zheng, Shuo Song, Chuanlai Yang, Hualong Xiong, Sibo Zhang, Minqing Hong, Yali Zhang, Hai Yu, Yuyun Zhang, Hui Sun, Yang Huang, Tingting Deng, Xin Chi, Jinjin Li, Shaojuan Wang, Lizhi Zhou, Tingting Chen, Yingbin Wang, Tong Cheng, Tianying Zhang, Quan Yuan, Qinjian Zhao, Jun Zhang, Jason S McLellan, Z Hong Zhou, Zheng Zhang, Shaowei Li, Ying Gu, Ningshao Xia

Journal: Nat Commun

PubMed ID: 34580306

Doi: 10.1038/s41467-021-25997-3

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Diffusion of a disordered protein on its folded ligand

Authors: Felix Wiggers, Samuel Wohl, Artem Dubovetskyi, Gabriel Rosenblum, Wenwei Zheng, Hagen Hofmann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34504002

Doi: 10.1073/pnas.2106690118

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Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression

Authors: Chinmoy Ghosh, Yanli Xing, Suhua Li, Rosalie G Hoyle, Ming Sun, Jiong Li, Yue Sun

Journal: FEBS Lett

PubMed ID: 34510437

Doi: 10.1002/1873-3468.14191

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Pathways of thymidine hypermodification

Authors: Yan-Jiun Lee, Nan Dai, Stephanie I Müller, Chudi Guan, Mackenzie J Parker, Morgan E Fraser, Shannon E Walsh, Janani Sridar, Andrew Mulholland, Krutika Nayak, Zhiyi Sun, Yu-Cheng Lin, Donald G Comb, Katherine Marks, Reyaz Gonzalez, Daniel P Dowling, Vahe Bandarian, Lana Saleh, Ivan R Corrêa, Peter R Weigele

Journal: Nucleic Acids Res

PubMed ID: 34522950

Doi: 10.1093/nar/gkab781

Products & Services: Codon Optimization

A Novel Miniature CRISPR-Cas13 System for SARS-CoV-2 Diagnostics

Authors: Ahmed Mahas, Qiaochu Wang, Tin Marsic, Magdy M Mahfouz

Journal: ACS Synth Biol

PubMed ID: 34546709

Doi: 10.1021/acssynbio.1c00181

Products & Services: Codon Optimization

Controlling the Orientation and Viscoelasticity of Materials-Binding Peptides on Hexagonal Boron Nitride Using Fatty Acids

Authors: Nermina Brljak, Marc R Knecht, Tiffany R Walsh

Journal: J Phys Chem B

PubMed ID: 34505506

Doi: 10.1021/acs.jpcb.1c05446

Products & Services: Catalog Peptides

In-yeast reconstruction of the African swine fever virus genome isolated from clinical samples

Authors: Fabien Labroussaa, Kemal Mehinagic, Valentina Cippa, Matthias Liniger, Hatice Akarsu, Nicolas Ruggli, Joerg Jores

Journal: STAR Protoc

PubMed ID: 34527959

Doi: 10.1016/j.xpro.2021.100803

Products & Services: Recombinant Proteins

Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak

Authors: Yu Nakagama, Yuko Komase, Katherine Candray, Sachie Nakagama, Fumiaki Sano, Tomoya Tsuchida, Hiroyuki Kunishima, Takumi Imai, Ayumi Shintani, Yuko Nitahara, Natsuko Kaku, Yasutoshi Kido

Journal: Microbiol Spectr

PubMed ID: 34550021

Doi: 10.1128/Spectrum.01082-21

Products & Services: Catalog Antibody

Hybrid fusion protein as a dual protease inhibitor for the healing of chronic wounds

Authors: Graham Strauss, Piyush Koria

Journal: Biotechnol Prog

PubMed ID: 34486249

Doi: 10.1002/btpr.3209

Products & Services: Gene Synthesis

Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism

Authors: Liang Ye, Daniel Schnepf, Annette Ohnemus, Li Ching Ong, Hans Henrik Gad, Rune Hartmann, Nils Lycke, Peter Staeheli

Journal: Front Immunol

PubMed ID: 34659250

Doi: 10.3389/fimmu.2021.749325

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Coiled coil exposure and histidine tags drive function of an intracellular protein drug carrier

Authors: Anshul Dhankher, Wei Lv, William T Studstill, Julie A Champion

Journal: J Control Release

PubMed ID: 34563592

Doi: 10.1016/j.jconrel.2021.09.026

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Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts

Authors: Yi Yu, Lishan Jiang, Jingwen Li, Lang Lei, Houxuan Li

Journal: J Periodontol

PubMed ID: 34585393

Doi: 10.1002/JPER.21-0227

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Safety and Immunogenicity of a Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate, AVX/COVID-12-HEXAPRO (Patria), in Pigs

Authors: Jesús Horacio Lara-Puente, Juan Manuel Carreño, Weina Sun, Alejandro Suárez-Martínez, Luis Ramírez-Martínez, Francisco Quezada-Monroy, Georgina Paz-De la Rosa, Rosalía Vigueras-Moreno, Gagandeep Singh, Oscar Rojas-Martínez, Héctor Elías Chagoya-Cortés, David Sarfati-Mizrahi, Ernesto Soto-Priante, Constantino López-Macías, Florian Krammer, Felipa Castro-Peralta, Peter Palese, Adolfo García-Sastre, Bernardo Lozano-Dubernard

Journal: MBio

PubMed ID: 34544278

Doi: 10.1128/mBio.01908-21

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Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes

Authors: Antoine Baudin, Alma K Moreno-Romero, Xiaoping Xu, Emily E Selig, Luiz O F Penalva, David S Libich

Journal: Front Mol Biosci

PubMed ID: 34631798

Doi: 10.3389/fmolb.2021.744707

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Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway

Authors: Jenan Al-Matouq, Latifa Al-Haj, Maher Al-Saif, Khalid S A Khabar

Journal: Oncogenesis

PubMed ID: 34535639

Doi: 10.1038/s41389-021-00351-w

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Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition

Authors: Amanda L Mohabeer, Jeffrey T Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J Broekelmann, Guangpei Hou, Hangjun Zhang, Yu-Qing Zhou, Minyao Wang, Anthony O Gramolini, Robert P Mecham, Scott P Heximer, Steffen-Sebastian Bolz, Michelle P Bendeck

Journal: Matrix Biol Plus

PubMed ID: 34693248

Doi: 10.1016/j.mbplus.2021.100085

Products & Services: Plasmid DNA Preparation

ReScribe: An Unrestrained Tool Combining Multiplex Recombineering and Minimal-PAM ScCas9 for Genome Recoding

Authors: Enrique Asin-Garcia, Maria Martin-Pascual, Luis Garcia-Morales, Richard van Kranenburg, Vitor A P Martins Dos Santos

Journal: ACS Synth Biol

PubMed ID: 34547891

Doi: 10.1021/acssynbio.1c00297

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MicroRNA-361 reduces the viability and migratory ability of pancreatic cancer cells via mediation of the MAPK/JNK pathway

Authors: Juan Wang, Zongjing Xie, Yan Liu, Weiguo Zhang, Tingting Ji

Journal: Exp Ther Med

PubMed ID: 34659511

Doi: 10.3892/etm.2021.10799

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Yeast Translational Activator Mss51p and Human ZMYND17 - Two Proteins with a Common Origin, but Different Functions

Authors: Maria V Baleva, Uliyana E Piunova, Ivan V Chicherin, Darya G Krasavina, Sergey A Levitskii, Piotr A Kamenski

Journal: Biochemistry (Mosc)

PubMed ID: 34565318

Doi: 10.1134/S0006297921090108

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Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase

Authors: Xida Zhao, Jingbo Liu, Chong Zhang, Ning Yu, Ze Lu, Shuwei Zhang, Yuchao Li, Qian Li, Junchao Liu, Dongjuan Liu, Yaping Pan

Journal: Int J Oral Sci

PubMed ID: 34593756

Doi: 10.1038/s41368-021-00136-2

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CLE14 functions as a "brake signal" to suppress age-dependent and stress-induced leaf senescence by promoting JUB1-mediated ROS scavenging in Arabidopsis

Authors: Zenglin Zhang, Cheng Liu, Kui Li, Xiaoxu Li, Mengmeng Xu, Yongfeng Guo

Journal: Mol Plant

PubMed ID: 34530165

Doi: 10.1016/j.molp.2021.09.006

Products & Services: Peptide Synthesis

Enhancing Antigen Presentation and Inducing Antigen-Specific Immune Tolerance with Amphiphilic Peptides

Authors: Meng Li, Arata Itoh, Jingchao Xi, Chunsong Yu, Yuehong Wu, William M Ridgway, Haipeng Liu

Journal: J Immunol

PubMed ID: 34526376

Doi: 10.4049/jimmunol.1901301

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Characterization of HLA-A*02:01 MHC Immunopeptide Antigens Enhanced by Ultraviolet Photodissociation Mass Spectrometry

Authors: Eleanor Watts, Gregory K Potts, Damien B Ready, Alayna M George Thompson, Janice Lee, Edwin E Escobar, Melanie J Patterson, Jennifer S Brodbelt

Journal: Anal Chem

PubMed ID: 34553926

Doi: 10.1021/acs.analchem.1c01002

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Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Authors: Zetian Shen, Han Zhou, Aomei Li, Tiancong Wu, Xiaoqin Ji, Lei Guo, Xixu Zhu, Dagan Zhang, Xia He

Journal: Aging (Albany NY)

PubMed ID: 34546972

Doi: 10.18632/aging.203464

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Bioinformatics Analysis of a Functional ANGPT1 Variant That Interferes with miR-607 and Its Association with Susceptibility and Outcome of Ischemic Stroke in a Han Population

Authors: Ai-Nian Chen, Ling-Ling Zhong, Ke-Ju Ju, Hua Cao

Journal: Ther Clin Risk Manag

PubMed ID: 34611404

Doi: 10.2147/TCRM.S328964

Products & Services: PCR Cloning and Subcloning

A Single Dose of a Hybrid hAdV5-Based Anti-COVID-19 Vaccine Induces a Long-Lasting Immune Response and Broad Coverage against VOC

Authors: M Verónica López, Sabrina E Vinzón, Eduardo G A Cafferata, Felipe J Núñez, Ariadna Soto, Maximiliano Sanchez-Lamas, M Jimena Afonso, Diana Aguilar-Cortes, Gregorio D Ríos, Juliana T Maricato, Carla T Braconi, Vanessa B Silveira, Tatiane M Andrad, Tatiana C S Bonetti, Luiz M Ramos Janini, Manoel J B C Girão, Andrea S Llera, Karina A Gomez, Hugo H Ortega, Paula M Berguer, Osvaldo L Podhajcer

Journal: Vaccines (Basel)

PubMed ID: 34696219

Doi: 10.3390/vaccines9101106

Products & Services: PCR Cloning and Subcloning

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling Elevating Suppressor of Cytokine Signaling 1

Authors: Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu

Journal: Front Microbiol

PubMed ID: 34650546

Doi: 10.3389/fmicb.2021.752597

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Plant Viral Nanoparticle Conjugated with Anti-PD-1 Peptide for Ovarian Cancer Immunotherapy

Authors: Aayushma Gautam, Veronique Beiss, Chao Wang, Lu Wang, Nicole F Steinmetz

Journal: Int J Mol Sci

PubMed ID: 34575893

Doi: 10.3390/ijms22189733

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The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer

Authors: Dianne J Beveridge, Kirsty L Richardson, Michael R Epis, Rikki A M Brown, Lisa M Stuart, Andrew J Woo, Peter J Leedman

Journal: Sci Rep

PubMed ID: 34504167

Doi: 10.1038/s41598-021-97190-x

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Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder

Authors: Luke Kowal, Jianhe Huang, Hongbin Luo, Jagmohan Singh, Adam E Snook, Jouni Uitto, Qiaoli Li

Journal: J Invest Dermatol

PubMed ID: 34597610

Doi: 10.1016/j.jid.2021.08.435

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complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Authors: Shinichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J Fowler, Tetsuhiro Yasuma, Shuichiro Hirahara, Reo Yasuma, Peirong Huang, Praveen Yerramothu, Ryan D Makin, Mo Wang, Kirstie L Baker, Kenneth M Marion, Xiwen Huang, Elmira Baghdasaryan, Meenakshi Ambati, Vidya L Ambati, Daipayan Banerjee, Vera L Bonilha, Genrich V Tolstonog, Ulrike Held, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Deepak Bhattarai, Kyung Bo Kim, Sanford H Feldman, J Ignacio Aguirre, David R Hinton, Nagaraj Kerur, Srinivas R Sadda, Gerald G Schumann, Bradley D Gelfand, Jayakrishna Ambati

Journal: Sci Adv

PubMed ID: 34586848

Doi: 10.1126/sciadv.abj3658

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TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

Authors: Suyan Wang, Mengmeng Yu, Aijing Liu, Yuanling Bao, Xiaole Qi, Li Gao, Yuntong Chen, Peng Liu, Yulong Wang, Lixiao Xing, Lingzhai Meng, Yu Zhang, Linjin Fan, Xinyi Li, Qing Pan, Yanping Zhang, Hongyu Cui, Kai Li, Changjun Liu, Xijun He, Yulong Gao, Xiaomei Wang

Journal: PLoS Pathog

PubMed ID: 34516573

Doi: 10.1371/journal.ppat.1009900

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CCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production

Authors: Nan Liang, Ming-Dong Yao, Ying Wang, Jia Liu, Lu Feng, Zhi-Ming Wang, Xiang-Yu Li, Wen-Hai Xiao, Ying-Jin Yuan

Journal: J Agric Food Chem

PubMed ID: 34554747

Doi: 10.1021/acs.jafc.1c04588

Products & Services: Mutagenesis Services

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

Authors: Laura T Gray, Michal M Raczy, Priscilla S Briquez, Tiffany M Marchell, Aaron T Alpar, Rachel P Wallace, Lisa R Volpatti, Maria Stella Sasso, Shijie Cao, Mindy Nguyen, Aslan Mansurov, Erica Budina, Elyse A Watkins, Ani Solanki, Nikolaos Mitrousis, Joseph W Reda, Shann S Yu, Andrew C Tremain, Ruyi Wang, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Balaji Manicassamy, Glenn Randall, D Scott Wilson, Marcin Kwissa, Melody A Swartz, Jeffrey A Hubbell

Journal: Biomaterials

PubMed ID: 34634664

Doi: 10.1016/j.biomaterials.2021.121159

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