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Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity

Authors: Ha N Duong, Sung-Hwan Cho, Limin Wang, An Q Pham, Julia M Davies, Gary Stacey

Journal: Plant J

PubMed ID: 34919778

Doi: 10.1111/tpj.15636

Products & Services: Catalog Peptides

Variation in Severe Acute Respiratory Syndrome Coronavirus 2 Bioaerosol Production in Exhaled Breath

Authors: Renu Verma, Eugene Kim, Nicholas Degner, Katharine S Walter, Upinder Singh, Jason R Andrews

Journal: Open Forum Infect Dis

PubMed ID: 35028332

Doi: 10.1093/ofid/ofab600

Products & Services: Plasmid DNA Preparation

MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2

Authors: Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu

Journal: Bioengineered

PubMed ID: 34699325

Doi: 10.1080/21655979.2021.1996505

Products & Services: Custom DNA/RNA Oligos

Creation of a recombinant Komagataella phaffii strain, a producer of proteinase K from Tritirachium album

Authors: A B Beklemishev, M B Pykhtina, Ya M Kulikov, T N Goryachkovskaya, D V Bochkov, S V Sergeeva, A R Vasileva, V P Romanov, D S Novikova, S E Peltek

Journal: Vavilovskii Zhurnal Genet Selektsii

PubMed ID: 35083407

Doi: 10.18699/VJ21.102

Products & Services: Bacterial Expression

Curcumin modulates airway remodelling-contributing genes-the significance of transcription factors

Authors: Joanna Wieczfinska, Przemysław Sitarek, Tomasz Kowalczyk, Piotr Rieske, Rafal Pawliczak

Journal: J Cell Mol Med

PubMed ID: 34939316

Doi: 10.1111/jcmm.17102

Products & Services: Protein Electrophoresis and Western

ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models

Authors: Linxi Zhu, Qingxin Mu, Jesse Yu, James I Griffin, Xiaolin Xu, Rodney J Y Ho

Journal: Pharmaceutics

PubMed ID: 35056985

Doi: 10.3390/pharmaceutics14010089

Products & Services: Gene Synthesis

Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

Authors: Jingru Guo, Yujing Bai, Yunxie Wei, Yabin Dong, Hongqiu Zeng, Russel J Reiter, Haitao Shi

Journal: J Pineal Res

PubMed ID: 34936113

Doi: 10.1111/jpi.12784

Products & Services: Protein and Antibody Isolation

An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

Products & Services: Gene Fragments

Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

Products & Services: Protein and Antibody Isolation

Synthesis of Human Bone Morphogenetic Protein-2 (hBMP-2) in Periplasmic Space: Its Characterization and Preclinical Testing

Authors: João E Oliveira, Miriam F Suzuki, Renata Damiani, Eliana R Lima, Kleicy C Amaral, Anderson M S Santos, Geraldo S Magalhães, Leonardo P Faverani, Luís A V D Pereira, Paolo Bartolini

Journal: Cells

PubMed ID: 34944033

Doi: 10.3390/cells10123525

Products & Services: Protein and Antibody Isolation

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

Authors: Sisi Shan, Chee Keng Mok, Shuyuan Zhang, Jun Lan, Jizhou Li, Ziqing Yang, Ruoke Wang, Lin Cheng, Mengqi Fang, Zhen Qin Aw, Jinfang Yu, Qi Zhang, Xuanling Shi, Tong Zhang, Zheng Zhang, Jianbin Wang, Xinquan Wang, Justin Jang Hann Chu, Linqi Zhang

Journal: Front Immunol

PubMed ID: 34966387

Doi: 10.3389/fimmu.2021.766821

Products & Services: Mammalian Expression

Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway

Authors: Kelan Yuan, Jiao Zheng, Xiao Shen, Yaying Wu, Yu Han, Xiuming Jin, Xiaodan Huang

Journal: Int Immunopharmacol

PubMed ID: 34906854

Doi: 10.1016/j.intimp.2021.108426

Products & Services: Protein and Antibody Isolation

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

Authors: Kimberly Nellenbach, Alexander Kyu, Nina Guzzetta, Ashley C Brown

Journal: Blood Adv

PubMed ID: 34555851

Doi: 10.1182/bloodadvances.2021004417

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Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression

Authors: Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng, Heng Song, Xiang Zhou

Journal: Nucleic Acids Res

PubMed ID: 34850126

Doi: 10.1093/nar/gkab1124

Products & Services: Protein and Antibody Isolation

Engineering Ligand and Receptor Pairs with LIPSTIC to Track Cell-Cell Interactions

Authors: Dafne Alberti, Michelle Guarniero, Agnieszka K Maciola, Enrico Dotta, Giulia Pasqual

Journal: Curr Protoc

PubMed ID: 34870906

Doi: 10.1002/cpz1.311

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SARS-CoV-2 vaccine in patients with systemic sclerosis: Impact of disease subtype and therapy

Authors: Percival Degrava Sampaio-Barros, Ana Cristina Medeiros-Ribeiro, Ana Paula Luppino-Assad, Renata Miossi, Henrique Carriço da Silva, Emily F V N Yuki, Sandra G Pasoto, Carla G S Saad, Clóvis A Silva, Léonard V K Kupa, Giordano B H Deveza, Tatiana N Pedrosa, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34894235

Doi: 10.1093/rheumatology/keab886

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Authors:

Journal: Lancet Infect Dis

PubMed ID: 34953520

Doi: 10.1016/S1473-3099(21)00751-9

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Cryptic splicing events result in unexpected protein products from calpain-10 (CAPN10) cDNA

Authors: Yasuko Ono, Naoko Doi, Mayumi Shindo, Pablo Pánico, Ana María Salazar

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 34906616

Doi: 10.1016/j.bbamcr.2021.119188

Products & Services: Protein Electrophoresis and Western

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

Authors: Jennifer West, Sandeep Satapathy, Daniel R Whiten, Megan Kelly, Nicholas J Geraghty, Emma-Jayne Proctor, Pietro Sormanni, Michele Vendruscolo, Joel N Buxbaum, Marie Ranson, Mark R Wilson

Journal: Sci Adv

PubMed ID: 34890220

Doi: 10.1126/sciadv.abf7606

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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Authors: Emma L Lewis, Rong Xu, Jean-Christophe Beltra, Shin Foong Ngiow, Jordana Cohen, Rahul Telange, Alexander Crane, Deirdre Sawinski, E John Wherry, Paige M Porrett

Journal: J Exp Med

PubMed ID: 34882194

Doi: 10.1084/jem.20201599

Products & Services: Protein and Antibody Isolation

The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction

Authors: Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang, Jianghua Zhong

Journal: Bioengineered

PubMed ID: 34506248

Doi: 10.1080/21655979.2021.1964894

Products & Services: Protein and Antibody Isolation

Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

Authors: Luke F Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S Jardetzky

Journal: Nat Commun

PubMed ID: 34862384

Doi: 10.1038/s41467-021-27397-z

Products & Services: Protein and Antibody Isolation

MON-2, a Golgi protein, mediates autophagy-dependent longevity in

Authors: Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom, Ara B Hwang, Dae-Eun Jeong, Özlem Altintas, Keunhee Seo, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Yujin Lee, Jooyeon Sohn, Eun Ji E Kim, Sungeun Ju, Seong Kyu Han, Hyun-Jun Nam, Linnea Adams, Youngjae Ryu, Dong Jin Moon, Chanhee Kang, Joo-Yeon Yoo, Sang Ki Park, Chang Man Ha, Malene Hansen, Sanguk Kim, Cheolju Lee, Seung-Yeol Park, Seung-Jae V Lee

Journal: Sci Adv

PubMed ID: 34860542

Doi: 10.1126/sciadv.abj8156

Products & Services: Protein and Antibody Isolation

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

Authors: Martin Houlard, Erin E Cutts, Muhammad S Shamim, Jonathan Godwin, David Weisz, Aviva Presser Aiden, Erez Lieberman-Aiden, Lothar Schermelleh, Kim Nasmyth, Alessandro Vannini

Journal: Elife

PubMed ID: 34850681

Doi: 10.7554/eLife.73348

Products & Services: Peptide Synthesis

BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

Authors: Qing-Tao Meng, Xian-Yu Liu, Xue-Ting Liu, Juan Liu, Admire Munanairi, Devin M Barry, Benlong Liu, Hua Jin, Yu Sun, Qianyi Yang, Fang Gao, Li Wan, Jiahang Peng, Jin-Hua Jin, Kai-Feng Shen, Ray Kim, Jun Yin, Ailin Tao, Zhou-Feng Chen

Journal: Elife

PubMed ID: 34919054

Doi: 10.7554/eLife.71689

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The Intragenesis and Synthetic Biology Approach towards Accelerating Genetic Gains on Strawberry: Development of New Tools to Improve Fruit Quality and Resistance to Pathogens

Authors: Victoria Súnico, José Javier Higuera, Francisco J Molina-Hidalgo, Rosario Blanco-Portales, Enriqueta Moyano, Antonio Rodríguez-Franco, Juan Muñoz-Blanco, José L Caballero

Journal: Plants (Basel)

PubMed ID: 35009061

Doi: 10.3390/plants11010057

Products & Services: Gene Synthesis

Characterization of Mutations Causing CYP21A2 Deficiency in Brazilian and Portuguese Populations

Authors: Mayara J Prado, Shripriya Singh, Rodrigo Ligabue-Braun, Bruna V Meneghetti, Thaiane Rispoli, Cristiane Kopacek, Karina Monteiro, Arnaldo Zaha, Maria L R Rossetti, Amit V Pandey

Journal: International Journal of Molecular Sciences

PubMed ID: 35008721

Doi: 10.3390/ijms23010296

Products & Services: Plasmid DNA Preparation PCR Cloning and Subcloning

Characterization of Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-Angle X-ray Scattering (SAXS)

Authors: Tatjana Schamber, Oliver Binas, Andreas Schlundt, Anna Wacker, Harald Schwalbe

Journal: Chembiochem

PubMed ID: 34847270

Doi: 10.1002/cbic.202100564

Products & Services: Plasmid DNA Preparation

Engineering CAR-T cells to activate small-molecule drugs in situ

Authors: Thomas J Gardner, J Peter Lee, Christopher M Bourne, Dinali Wijewarnasuriya, Nihar Kinarivala, Keifer G Kurtz, Broderick C Corless, Megan M Dacek, Aaron Y Chang, George Mo, Kha M Nguyen, Renier J Brentjens, Derek S Tan, David A Scheinberg

Journal: Nat Chem Biol

PubMed ID: 34969970

Doi: 10.1038/s41589-021-00932-1

Products & Services: Protein and Antibody Isolation

A single injection of CM1021, a long half-life hepatocyte growth factor mimetic, increases liver mass in mice

Authors:

Journal: Biochem Biophys Rep

PubMed ID: 34977363

Doi: 10.1016/j.bbrep.2021.101186

Products & Services: Plasmid DNA Preparation

SARS-CoV-2 evolved during advanced HIV disease immunosuppression has Beta-like escape of vaccine and Delta infection elicited immunity

Authors: Sandile Cele, Farina Karim, Gila Lustig, James Emmanuel San, Tandile Hermanus, Houriiyah Tegally, Jumari Snyman, Thandeka Moyo-Gwete, Eduan Wilkinson, Mallory Bernstein, Khadija Khan, Shi-Hsia Hwa, Sasha W Tilles, Lavanya Singh, Jennifer Giandhari, Ntombifuthi Mthabela, Matilda Mazibuko, Yashica Ganga, Bernadett I Gosnell, Salim Abdool Karim, Willem Hanekom, Wesley C Van Voorhis, Thumbi Ndung'u, Richard J Lessells, Penny L Moore, Mahomed-Yunus S Moosa, Tulio de Oliveira, Alex Sigal

Journal: medrxiv

PubMed ID: 34909798

Doi: 10.1101/2021.09.14.21263564

Products & Services: Monoclonal Antibody Services

Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic

Authors: Justin R Randall, Gillian Davidson, Renee M Fleeman, Santos A Acosta, Ian M Riddington, T Jeffrey Cole, Cory D DuPai, Bryan W Davies

Journal: iScience

PubMed ID: 35005555

Doi: 10.1016/j.isci.2021.103611

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Mechanistic Insights into the Preference for Tandem Binding Sites in DNA Recognition by FOXM1

Authors: Huajun Zhang, Shuyan Dai, Xujun Liang, Jun Li, Yongheng Chen

Journal: J Mol Biol

PubMed ID: 34973238

Doi: 10.1016/j.jmb.2021.167426

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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Authors: Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux

Journal: Elife

PubMed ID: 34964715

Doi: 10.7554/eLife.74512

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Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy

Authors: Hassan Issafras, Shilong Fan, Chi-Ling Tseng, Yunchih Cheng, Peihua Lin, Lisa Xiao, Yun-Ju Huang, Chih-Hsiang Tu, Ya-Chin Hsiao, Min Li, Yen-Hsiao Chen, Chien-Hsin Ho, Ou Li, Yanling Wang, Sandra Chen, Zhenyu Ji, Eric Zhang, Yi-Ting Mao, Eugene Liu, Shumin Yang, Weidong Jiang

Journal: PLoS ONE

PubMed ID: 34972111

Doi: 10.1371/journal.pone.0257972

Products & Services: Gene Fragments

Impact of Molecular Modifications on the Immunogenicity and Efficacy of Recombinant Raccoon Poxvirus-Vectored Rabies Vaccine Candidates in Mice

Authors: Carly M Malavé, Jaime Lopera-Madrid, Lex G Medina-Magües, Tonie E Rocke, Jorge E Osorio

Journal: Vaccines (Basel)

PubMed ID: 34960182

Doi: 10.3390/vaccines9121436

Products & Services: Plasmid DNA Preparation

Development of a Highly Sensitive Luciferase-Based Reporter System To Study Two-Step Protein Secretion in Cyanobacteria

Authors: David A Russo, Julie A Z Zedler, Fabian D Conradi, Nils Schuergers, Poul Erik Jensen, Conrad W Mullineaux, Annegret Wilde, Georg Pohnert

Journal: J Bacteriol

PubMed ID: 34898262

Doi: 10.1128/JB.00504-21

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Different response of Acipenser gueldenstaedtii CRP/SAP and SAA to bacterial challenge and chronic thermal stress sheds light on the innate immune system of sturgeons

Authors: Marcio Aversa-Marnai, Mauricio Castellano, Ignacio Quartiani, Daniel Conijesky, Alejandro Perretta, Andrea Villarino, Valeria Silva-Álvarez, Ana María Ferreira

Journal: Fish Shellfish Immunol

PubMed ID: 34971737

Doi: 10.1016/j.fsi.2021.12.029

Products & Services: Recombinant Proteins

Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients

Authors: Qihong Yan, Ping He, Xiaohan Huang, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu, Xuefeng Niu, Ling Chen

Journal: Emerg Microbes Infect

PubMed ID: 33944697

Doi: 10.1080/22221751.2021.1925594

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Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease

Authors: Jeong Seok Yu, Gi Soo Youn, Jieun Choi, Chang-Ho Kim, Byung Yong Kim, Seung-Jo Yang, Je Hee Lee, Tae-Sik Park, Byoung Kook Kim, Yeon Bee Kim, Seong Woon Roh, Byeong Hyun Min, Hee Jin Park, Sang Jun Yoon, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Hotaik Sung, Sang Hak Han, Ki Tae Suk, Do Yup Lee

Journal: Clin Transl Med

PubMed ID: 34965016

Doi: 10.1002/ctm2.634

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P2X7 receptor: the regulator of glioma tumor development and survival

Authors: Damian Matyśniak, Vira Chumak, Natalia Nowak, Artur Kukla, Lilya Lehka, Magdalena Oslislok, Paweł Pomorski

Journal: Purinergic Signal

PubMed ID: 34964926

Doi: 10.1007/s11302-021-09834-2

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EZH2 targeting to improve the sensitivity of acquired radio-resistance bladder cancer cells

Authors: Xiangyan Zhang, Xiangli Ma, Quanxin Wang, Zhaolu Kong

Journal: Transl Oncol

PubMed ID: 34952334

Doi: 10.1016/j.tranon.2021.101316

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T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways

Authors: Haixia Liu, Mei Song, Xiaoyan Sun, Xin Zhang, Huayan Miao, Yankui Wang

Journal: Bioengineered

PubMed ID: 33557670

Doi: 10.1080/21655979.2021.1880732

Products & Services: Plasmid DNA Preparation

Staphylococcus aureus N-terminus formylated δ-toxin tends to form amyloid fibrils, while the deformylated δ-toxin tends to form functional oligomer complexes

Authors: Xinyu Zhou, Yuling Zheng, Qingyu Lv, Decong Kong, Bin Ji, Xuelian Han, Dongsheng Zhou, Zeyu Sun, Li Zhu, Peng Liu, Hua Jiang, Yongqiang Jiang

Journal: Virulence

PubMed ID: 34028320

Doi: 10.1080/21505594.2021.1928395

Products & Services: Nucleic Acid Purification

Advances in Approaches to Study Chromatin-Mediated Epigenetic Memory

Authors: Yuan Yao, Qing Wen, Tianjun Zhang, Chuanhe Yu, Kui Ming Chan, Haiyun Gan

Journal: ACS Synth Biol

PubMed ID: 34965084

Doi: 10.1021/acssynbio.1c00394

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Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway

Authors: Man Luo, Wei Sun, Xiangqing Kong

Journal: Ann Anat

PubMed ID: 34958913

Doi: 10.1016/j.aanat.2021.151885

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MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)

Authors: Huang Jinghua, Zhou Qinghua, Chen Chenchen, Chen Lili, Xu Xiao, Wang Yunfei, An Zhengzhe, Lin Changxiu, Han Hui

Journal: Bioengineered

PubMed ID: 34082648

Doi: 10.1080/21655979.2021.1924543

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Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Authors: Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K W To, Kwok-Yung Yuen, Kin-Hang Kok

Journal: Emerg Microbes Infect

PubMed ID: 34003073

Doi: 10.1080/22221751.2021.1931465

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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Authors: Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Cathrine Knetter, Mete Can Odabasi, Ravi Chand Bollineni, Xinbo Yang, Zsofia Foldvari, Maxi-Lu Böschen, Eli Taraldsrud, Erlend Strønen, Mireille Toebes, Amy Hillen, Stefania Mazzi, Arnoud H de Ru, George M C Janssen, Arne Kolstad, Geir Erland Tjønnfjord, Benedicte A Lie, Marieke Griffioen, Sören Lehmann, Liv Toril Osnes, Jochen Buechner, K Christopher Garcia, Ton N Schumacher, Peter A van Veelen, Matthias Leisegang, Sten Eirik W Jacobsen, Petter Woll, Johanna Olweus

Journal: Nat Biotechno.

PubMed ID: 34873326

Doi: 10.1038/s41587-021-01089-x

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Increased SERPINA3 Level Is Associated with Ulcerative Colitis

Authors: Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen

Journal: Diagnostics (Basel)

PubMed ID: 34943607

Doi: 10.3390/diagnostics11122371

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

Authors: Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, and Moutih Rafe

Journal: Cell Reports Medicine

PubMed ID: 35028603

Doi: 10.1016/j.xcrm.2021.100455

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An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility

Authors: Abhishek Das, Satarupa Dutta, Dewanshu Sharma, Amit Pal, Nirmalya Ganguli, Subeer S Majumdar

Journal: Bioengineered

PubMed ID: 34436976

Doi: 10.1080/21655979.2021.1955509

Products & Services: PCR Cloning and Subcloning

Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM

Authors: Fuji Lai, Huiqin Zhang, Binbin Xu, Yangyang Xie, Hua Yu

Journal: Bioengineered

PubMed ID: 34506209

Doi: 10.1080/21655979.2021.1958558

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Study protocol for a randomised clinical trial of a decision aid and values clarification method for parents of a fetus or neonate diagnosed with a life-threatening congenital heart defect

Authors: Rebecca K Delaney, Nelangi M Pinto, Elissa M Ozanne, Louisa A Stark, Mandy L Pershing, Alistair Thorpe, Holly O Witteman, Praveen Thokala, Linda M Lambert, Lisa M Hansen, Tom H Greene, Angela Fagerlin

Journal: BMJ Open

PubMed ID: 34893487

Doi: 10.1136/bmjopen-2021-055455

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Analysis of Immunoreactivity of α/α-Tropomyosin from , Based on IgE Epitopes and Structural Characteristics

Authors: Nai-Ru Ji, Xin-Yu Han, Chen-Chen Yu, Yu-Jia Wang, Xin-Rong He, Hong Liu, Fei Huan, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: J Agric Food Chem

PubMed ID: 34881872

Doi: 10.1021/acs.jafc.1c06401

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Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity

Authors: Meng-Meng Chen, Si-Ru Yang, Jian Wang, Ya-Li Fang, You-Liang Peng, Jun Fan

Journal: J Exp Bot

PubMed ID: 34864987

Doi: 10.1093/jxb/erab530

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In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion

Authors: Xiaocui Li, Min An, Zhenjun Gao

Journal: J Oncol

PubMed ID: 34899909

Doi: 10.1155/2021/7430468

Products & Services: Protein and Antibody Isolation

Lysine β-Hydroxybutyrylation Improves Stability of COVID-19 Antibody

Authors: Zihua Li, Yudian Zhang, Meng Han, Haiteng Deng, Fuqing Wu, Gang Liu, Guo-Qiang Chen

Journal: Biomacromolecules

PubMed ID: 34879647

Doi: 10.1021/acs.biomac.1c01435

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Novel carotenogenic gene combinations from red yeasts enhanced lycopene and beta-carotene production in Saccharomyces cerevisiae from the low-cost substrate sucrose

Authors: Akaraphol Watcharawipas, Kitisak Sansatchanon, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Weerawat Runguphan, Kanokarn Kocharin

Journal: FEMS Yeast Res

PubMed ID: 34865010

Doi: 10.1093/femsyr/foab062

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Silencing an E3 Ubiquitin Ligase Gene OsJMJ715 Enhances the Resistance of Rice to a Piercing-Sucking Herbivore by Activating ABA and JA Signaling Pathways

Authors: Yuebai Zhang , Mengting Chen , Shuxing Zhou , Yonggen Lou , Jing Lu

Journal: Int J Mol Sci

PubMed ID: 34884830

Doi: 10.3390/ijms222313020

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Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

Authors: Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown

Journal: EMBO J

PubMed ID: 34942047

Doi: 10.15252/embj.2021108823

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Development and validation of novel kit for quantification of SARS-CoV-2 antibodies on clinical samples

Authors: Sneha Kumari, Anoushka Raina, Dinesh Chandra, Nikita Gupta, Nikki Dey, Amit Kumar Bhardwaj, Archana Anthwal, Vikash C Mishra, Vimarsh Raina, Aseem K Tiwari, Rasika Setia, A S Bhatia

Journal: J Virol Methods

PubMed ID: 34919976

Doi: 10.1016/j.jviromet.2021.114423

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Preclinical Immune Response and Safety Evaluation of the Protein Subunit Vaccine Nanocovax for COVID-19

Authors: Thi Nhu Mai Tran, Bruce Pearson May, Trong Thuan Ung, Mai Khoi Nguyen, Thi Thuy Trang Nguyen, Van Long Dinh, Chinh Chung Doan, The Vinh Tran, Hiep Khong, Thi Thanh Truc Nguyen, Hoang Quoc Huy Hua, Viet Anh Nguyen, Tan Phat Ha, Dang Luu Phan, Truong An Nguyen, Thi Ngoc Bui, Tieu My Tu, Thi Theo Nguyen, Thi Thuy Hang Le, Thi Lan Dong, Trong Hieu Huynh, Phien Huong Ho, Nguyen Thanh Thao Le, Cong Thao Truong, Hoang Phi Pham, Cong Y Luong, Nie Lim Y, Minh Ngoc Cao, Duy Khanh Nguyen, Thi Thanh Le, Duc Cuong Vuong, Le Khanh Hang Nguyen, Minh Si Do

Journal: Front Immunol

PubMed ID: 34938290

Doi: 10.3389/fimmu.2021.766112

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A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

Authors: Kangli Cao, Xiang Wang, Haoran Peng, Longfei Ding, Xiangwei Wang, Yangyang Hu, Lanlan Dong, Tianhan Yang, Xiujing Hong, Man Xing, Duoduo Li, Cuisong Zhu, Xiangchuan He, Chen Zhao, Ping Zhao, Dongming Zhou, Xiaoyan Zhang, Jianqing Xu

Journal: J Virol

PubMed ID: 34908443

Doi: 10.1128/JVI.01578-21

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Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T‑Cell Epitopes for Cancer Immunotherapy

Authors: Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, and Yumiao Zhang

Journal: Chem. Mater.

Doi: 10.1021/acs.chemmater.1c03681

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Targeting cIAPs attenuates CCl-induced liver fibrosis by increasing MMP9 expression derived from neutrophils

Authors: Yi Wu, Suwen Lu, Xuan Huang, Yuanyuan Liu, Kuiyuan Huang, Ziying Liu, Weikang Xu, Wei Zhu, Jinlin Hou, Hongyan Liu, Xiaoyong Zhang

Journal: Life Sci

PubMed ID: 34914932

Doi: 10.1016/j.lfs.2021.120235

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hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis

Authors: Pei Cao, Bo Ma, Ding Sun, Weigang Zhang, Junyi Qiu, Lei Qin, Xiaofeng Xue

Journal: Cancer Sci

PubMed ID: 34890089

Doi: 10.1111/cas.15238

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Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling

Authors: Yingrui Deng, Xiaoting Zhang, Rui Li, Zhuo Li, Boguang Yang, Peng Shi, Honglu Zhang, Chunming Wang, Chunyi Wen, Gang Li, Liming Bian

Journal: Biomaterials

PubMed ID: 34959028

Doi: 10.1016/j.biomaterials.2021.121316

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Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

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Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials

Authors: Jill Whitley, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, Hong Liao, Sean Chiou, Tina Marmura, Holly Zoeller, Ben Hudson, John Peart, Monica Johnson, Amelia Karlsson, Yunfei Wang, Cynthia Nagle, Cherell Harris, Daniel Tonkin, Stephanie Fraser, Lieza Capiz, Christina L Zeno, Yvonne Meli, Diana Martik, Daniel A Ozaki, Amy Caparoni, Jason E Dickens, Drew Weissman, Kevin O Saunders, Barton F Haynes, Gregory D Sempowski, Thomas N Denny, Matthew R Johnson

Journal: Transl Res

PubMed ID: 34871810

Doi: 10.1016/j.trsl.2021.11.009

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Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)

Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller

Journal: Biophys Chem

PubMed ID: 34953381

Doi: 10.1016/j.bpc.2021.106745

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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An immunochromatographic assay utilizing magnetic nanoparticles to detect major peanut allergen Ara h 1 in processed foods

Authors: Hsin-Yi Yin, Yi-Ting Li, Wen-Che Tsai, Hong-Yu Dai, Hsiao-Wei Wen

Journal: Food Chem

PubMed ID: 34952385

Doi: 10.1016/j.foodchem.2021.131844

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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver

Authors: Leire Goicoechea, Fabian Arenas, Fernanda Castro, Susana Nuñez, Sandra Torres, Carmen Garcia-Ruiz, José C Fernandez-Checa

Journal: STAR Protoc

PubMed ID: 35024626

Doi: 10.1016/j.xpro.2021.101068

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Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers

Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen

Journal: Hum Mutat

PubMed ID: 34923709

Doi: 10.1002/humu.24321

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Critical residues for proteolysis activity of maize chlorotic dwarf virus (MCDV) 3C-like protease and comparison of activity of orthologous waikavirus proteases

Authors: Lucy R Stewart, Matthew Willman, DeeMarie Marty, Anna Emmick Cole, Kristen Willie

Journal: Virology

PubMed ID: 34998226

Doi: 10.1016/j.virol.2021.12.008

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BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

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Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

Authors: Nessma A El-Zawawy, Mahy M Mona

Journal: Sci Rep

PubMed ID: 34934098

Doi: 10.1038/s41598-021-03664-3

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The key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus

Authors: Dan Wang, Zhanmin Sun, Xinxu Hu, Junbo Xiong, Lizhen Hu, Yuandong Xu, Yixiong Tang, Yanmin Wu

Journal: BMC Plant Biol

PubMed ID: 34965872

Doi: 10.1186/s12870-021-03336-4

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KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3

Authors: Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun

Journal: Int J Mol Sci

PubMed ID: 35008530

Doi: 10.3390/ijms23010104

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ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes

Authors: Jessica M Hong, Michael Gibbons, Ali Bashir, Diana Wu, Shirley Shao, Zachary Cutts, Mariya Chavarha, Ye Chen, Lauren Schiff, Mikelle Foster, Victoria A Church, Llyke Ching, Sara Ahadi, Anna Hieu-Thao Le, Alexander Tran, Michelle Dimon, Marc Coram, Brian Williams, Phillip Jess, Marc Berndl, Annalisa Pawlosky

Journal: iScience

PubMed ID: 35005536

Doi: 10.1016/j.isci.2021.103586

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NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes

Authors: Juan Fan, Jiawei Shi, Yong Zhang, Junwei Liu, Chenyi An, Huaying Zhu, Peng Wu, Wei Hu, Rui Qin, Danmei Yao, Xin Shou, Yibing Xu, Zhou Tong, Xue Wen, Jianpo Xu, Jin Zhang, Weijia Fang, Jizhong Lou, Weiwei Yin, Wei Chen

Journal: EMBO J

PubMed ID: 34913508

Doi: 10.15252/embj.2021107739

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Cell-Penetrating Antimicrobial Peptides Derived from an Atypical Staphylococcal δ-Toxin

Authors: Kathyana Deeyagahage, Antonio Ruzzini

Journal: Microbiol Spectr

PubMed ID: 34937169

Doi: 10.1128/spectrum.01584-21

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SARS-CoV-2 prevalence and immunity: a hospital-based study from Malawi

Authors: C Meinus, R Singer, B Nandi, O Jagot, B Becker-Ziaja, B Karo, B Mvula, A Jansen, J Baumann, A Schultz

Journal: Int J Infect Dis

PubMed ID: 34929356

Doi: 10.1016/j.ijid.2021.12.336

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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children

Authors: Eder Gatti Fernandes, Giselle Ibette Silva López-Lopes, Valeria Oliveira Silva, Rosemeire Yamashiro, Karen Cristina Rolim Madureira, Juliana Failde Gallo, José Angelo Lindoso, Helena Keico Sato, Núbia Virginia D'Avila Limeira de Araujo, Maria Ligia Bacciotte Ramos Nerger, Luis Fernando Macedo Brigido

Journal: Rev Inst Med Trop Sao Paulo

PubMed ID: 34878041

Doi: 10.1590/S1678-9946202163083

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Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1

Authors: Wenliang Song, Tiening Zhang, Ni Yang, Tao Zhang, Ri Wen, Chunfeng Liu

Journal: Bioengineered

PubMed ID: 34002676

Doi: 10.1080/21655979.2021.1926201

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Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases

Authors: Bruno Gualano, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J Pinto, Bruna C Mazzolani, Fabiana I Smaira, Sofia M Sieczkowska, Nadia E Aikawa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuk, Clovis A Silva, Paul Swinton, Pedro C Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Brain Behav Immun

PubMed ID: 34954325

Doi: 10.1016/j.bbi.2021.12.016

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The large nonstructural protein (NS1) of the human bocavirus 1 (HBoV1) directly interacts with Ku70, which plays an important role in virus replication in human airway epithelia

Authors: Liting Shao, Kang Ning, Jianke Wang, Fang Cheng, Shengqi Wang, Jianming Qiu

Journal: J Virol

PubMed ID: 34878919

Doi: 10.1128/JVI.01840-21

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Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins

Authors: Jieping Deng , Junping Pan, Minghui Qiu, Lipeng Mao , Zhigang Wang , Guodong Zhu , Lijuan Gao , Jun Su , Yutian Hu , Oscar Junhong Luo , Guobing Chen , Pengcheng Wang

Journal: J Leukoc Biol

PubMed ID: 34231935

Doi: 10.1002/JLB.4MA0621-020R

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Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice

Authors: Wenjuan Li , Xingxing Li , Danhua Zhao , Jingjing Liu , Ling Wang , Miao Li , Xinyu Liu , Jia Li , Xiaohong Wu , Yuhua Li

Journal: Signal Transduct Target Ther

PubMed ID: 34903732

Doi: 10.1038/s41392-021-00843-6

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Convergent phenotypic evolution of rhodopsin for dim-light sensing across deep-diving vertebrates

Authors: Yu Xia , Yimeng Cui , Aishan Wang , Fangnan Liu , Hai Chi , Joshua H T Potter , Joseph Williamson , Xiaolan Chen , Stephen J Rossiter , Yang Liu

Journal: Mol Biol Evol

PubMed ID: 34463769

Doi: 10.1093/molbev/msab262

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Nano-immobilization of PETase enzyme for enhanced polyethylene terephthalate biodegradation

Authors: Yunpu Jia , Nadia A. Samak , Xuemi Hao , Zheng Chen , Gama Yang , Xuhao Zhao , Tingzhen Mu , Maohua Yang , Jianmin Xing

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2021.108205

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Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

Authors: Richard N Day, Kathleen H Day, Fredrick M Pavalko

Journal: PLoS ONE

PubMed ID: 34941939

Doi: 10.1371/journal.pone.0261660

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Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model

Authors: Gustavo Luis Verón, María Florencia Veiga, Mónica Cameo, Clara Isabel Marín-Briggiler, Mónica Hebe Vazquez-Levin

Journal: Cells

PubMed ID: 35011663

Doi: 10.3390/cells11010102

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Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

Authors: I-Ting Teng, Alexandra F Nazzari, Misook Choe, Tracy Liu, Matheus Oliveira de Souza, Yuliya Petrova, Yaroslav Tsybovsky, Shuishu Wang, Baoshan Zhang, Mykhaylo Artamonov, Bharat Madan, Aric Huang, Sheila N Lopez Acevedo, Xiaoli Pan, Tracy J Ruckwardt, Brandon J DeKosky, John R Mascola, John Misasi, Nancy J Sullivan, Tongqing Zhou, Peter D Kwong

Journal: PLoS ONE

PubMed ID: 35609088

Doi: 10.1101/2021.12.29.474491

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Single-Dose Vaccination of Recombinant Chimeric Newcastle Disease Virus (NDV) LaSota Vaccine Strain Expressing Infectious Bursal Disease Virus (IBDV) VP2 Gene Provides Full Protection against Genotype VII NDV and IBDV Challenge

Authors: Qilong Qiao, Mingzhen Song, Congcong Song, Yihang Zhang, Xiangdong Wang, Qing Huang, Baiyu Wang, Panpan Yang, Shiyi Zhao, Yongtao Li, Zeng Wang, Jun Zhao

Journal: Vaccines (Basel)

PubMed ID: 34960229

Doi: 10.3390/vaccines9121483

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