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Protein identification by nanopore peptide profiling

Authors: Florian Leonardus Rudolfus Lucas, Roderick Corstiaan Abraham Versloot, Liubov Yakovlieva, Marthe T C Walvoort, Giovanni Maglia

Journal: Nat Commun

PubMed ID: 34608150

Doi: 10.1038/s41467-021-26046-9

Products & Services: Plasmid DNA Preparation

Neuroblastoma differentiation in vivo excludes cranial tumors

Authors: Randall W Treffy, Sriivatsan G Rajan, Xinghang Jiang, Lynne M Nacke, Usama A Malkana, L A Naiche, Dani E Bergey, Dianicha Santana, Vinodh Rajagopalan, Jan K Kitajewski, John P O'Bryan, Ankur Saxena

Journal: Dev Cell

PubMed ID: 34610330

Doi: 10.1016/j.devcel.2021.09.014

Products & Services: Plasmid DNA Preparation

Pentavalent Disabled Infectious Single Animal (DISA)/DIVA Vaccine Provides Protection in Sheep and Cattle against Different Serotypes of Bluetongue Virus

Authors: Piet A van Rijn, Mieke A Maris-Veldhuis, Massimo Spedicato, Giovanni Savini, René G P van Gennip

Journal: Vaccines (Basel)

PubMed ID: 34696258

Doi: 10.3390/vaccines9101150

Products & Services: Plasmid DNA Preparation

The novel ORFV protein ORFV113 activates LPA-p38 signaling

Authors: Sushil Khatiwada, Gustavo Delhon, Sabal Chaulagain, Daniel L Rock

Journal: PLoS Pathog

PubMed ID: 34614034

Doi: 10.1371/journal.ppat.1009971

Products & Services: ORF cDNA Clones/MolecularCloud

Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3

Authors: Bingting Ma, Cuiqing Huang, Jun Ma, Ye Xiang, Xinzheng Zhang

Journal: Nature

PubMed ID: 34646021

Doi: 10.1038/s41586-021-03909-1

Products & Services: Mutant Libraries

Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis

Authors: Yang Jiang, Xiao-Yu Yu, Hui-Xin Sun, Xin-Yue Gu, Jing-Shu Geng

Journal: J Physiol Biochem

PubMed ID: 34671931

Doi: 10.1007/s13105-021-00832-x

Products & Services: Mutant Libraries

The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series

Authors: Min Sun, Jonathan W Mueller, Lorna C Gilligan, Angela E Taylor, Fozia Shaheen, Anna Noczyńska, Guy T'Sjoen, Louise Denvir, Savitha Shenoy, Piers Fulton, Timothy D Cheetham, Helena Gleeson, Mushtaqur Rahman, Nils P Krone, Norman F Taylor, Cedric H L Shackleton, Wiebke Arlt, Jan Idkowiak

Journal: Eur J Endocrinol

PubMed ID: 34524979

Doi: 10.1530/EJE-21-0152

Products & Services: Mutant Libraries

Structural evidence for visual arrestin priming via complexation of phosphoinositols

Authors: Christopher L Sander, Jennings Luu, Kyumhyuk Kim, David Furkert, Kiyoung Jang, Joerg Reichenwallner, MinSoung Kang, Ho-Jun Lee, Bryan T Eger, Hui-Woog Choe, Dorothea Fiedler, Oliver P Ernst, Yong Ju Kim, Krzysztof Palczewski, Philip D Kiser

Journal: Structure

PubMed ID: 34678158

Doi: 10.1016/j.str.2021.10.002

Products & Services: Mutant Libraries

SARS-CoV-2 Neutralizing Antibody Levels Post COVID-19 Vaccination Based on ELISA Method-A Small Real-World Sample Exploration

Authors: Xiaoguang Li, Chao Liang, Xiumei Xiao

Journal: Vaccines (Basel)

PubMed ID: 34696247

Doi: 10.3390/vaccines9101139

Products & Services: Molecular Biology Reagents

Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway

Authors: Yan Wu, Gaolin Qiu, Hainie Zhang, Leilei Zhu, Gao Cheng, Yiqiao Wang, Yuanhai Li, Weiwei Wu

Journal: J Cell Mol Med

PubMed ID: 34664412

Doi: 10.1111/jcmm.16871

Products & Services: Mammalian Expression

Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4

Authors: Erin M O'Brien, Kara L Spiller

Journal: J Leukoc Biol

PubMed ID: 34643290

Doi: 10.1002/JLB.3A0520-338R

Products & Services: Mammalian Expression

SARS-CoV-2 Delta variant infects ACE2 primary human bronchial epithelial cells more efficiently than other variants

Authors: Hongmei Li, Ting Liu, Liping Wang, Minghui Wang, Shaoqing Wang

Journal: J Med Virol

PubMed ID: 34596249

Doi: 10.1002/jmv.27372

Products & Services: Mammalian Expression

Assessment of Anti-SARS-CoV-2 Antibodies Post-Coronavac Vaccination in the Amazon Region of Brazil

Authors: Carlos David Araújo Bichara, Maria Alice Freitas Queiroz, Ednelza da Silva Graça Amoras, Gergiane Lopes Vaz, Izaura Maria Vieira Cayres Vallinoto, Cléa Nazaré Carneiro Bichara, Isabella Pinheiro Costa do Amaral, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Journal: Vaccines (Basel)

PubMed ID: 34696277

Doi: 10.3390/vaccines9101169

Products & Services: Immunoassay Development Services

Surface-Tethered Planar Membranes Containing the β-Barrel Assembly Machinery: a platform for Investigating Bacterial Outer Membrane Protein Folding

Authors: Stephen C L Hall, Luke A Clifton, Pooja Sridhar, David J Hardy, Peter Wotherspoon, Jack Wright, James Whitehouse, Nadisha Gamage, Claire S Laxton, Caitlin Hatton, Gareth W Hughes, Mark Jeeves, Timothy J Knowles

Journal: Biophys J

PubMed ID: 34757080

Doi: 10.1016/j.bpj.2021.10.033

Products & Services: GenParts™ DNA Fragments

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O Burzio, Verónica A Burzio

Journal: Biol Res

PubMed ID: 34666824

Doi: 10.1186/s40659-021-00356-0

Products & Services: GenParts™ DNA Fragments

Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Authors: Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu, Banumathi Sankaran, Mary K Estes, B V Venkataram Prasad, James E Crowe

Journal: Nat Commun

PubMed ID: 34650069

Doi: 10.1038/s41467-021-26418-1

Products & Services: GenParts™ DNA Fragments

Biodegradation of 4-hydroxybenzoic acid by Acinetobacter johnsonii FZ-5 and Klebsiella oxytoca FZ-8 under anaerobic conditions

Authors: Peng Lu, Huiying Huang, Yixiao Sun, Mengyao Qiang, Yan Zhu, Mengjiao Cao, Xue Peng, Bo Yuan, Zhaozhong Feng

Journal: Biodegradation

PubMed ID: 34609628

Doi: 10.1007/s10532-021-09963-w

Products & Services: DNA Sequencing

Corrigendum: Upregulated LINC01667 Expression Is Correlated With Poor Prognosis in Hepatocellular Carcinoma

Authors: Kainan Zhang, Hui Liu, Mengsi Yu, Hui Zhao, Ning Yang, Xiaojuan Bi, Li Sun, Renyong Lin, Guodong Lü

Journal: Front Oncol

PubMed ID: 34722323

Doi: 10.3389/fonc.2021.785394

Products & Services: DNA Sequencing

Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Based on the CRISPR-Cas12a System

Authors: Hui Qian, Wei Wei, Xin-Ai Chen, Xiao-Ting Mo, Mei Ge, Qing-Wei Zhao, Yong-Quan Li

Journal: ACS Synth Biol

PubMed ID: 34628852

Doi: 10.1021/acssynbio.1c00317

Products & Services: DNA Sequencing

Development of Neutralizing Multimeric Nanobody Constructs Directed against IL-13: From Immunization to Lead Optimization

Authors: Philippe J-L Y Gevenois, Pieter De Pauw, Steve Schoonooghe, Cédric Delporte, Thami Sebti, Karim Amighi, Serge Muyldermans, Nathalie Wauthoz

Journal: J Immunol

PubMed ID: 34645688

Doi: 10.4049/jimmunol.2100250

Products & Services: DNA Sequencing

Development of Rapid and Visual Nucleic Acid Detection Methods towards Four Serotypes of Human Adenovirus Species B Based on RPA-LF Test

Authors: Yong Qi, Wei Li, Xiaoling Li, Wanpeng Shen, Jinhai Zhang, Jiameng Li, Ruichen Lv, Nianhong Lu, Liqiang Zong, Susu Zhuang, Qiyuan Gui, Dongming Zhou, Jing Li, Yingjia Xu, Hongbing Shen, Yuexi Li

Journal: Biomed Res Int

PubMed ID: 34646888

Doi: 10.1155/2021/9957747

Products & Services: DNA Sequencing

Antigenicity and immunogenicity of recombinant proteins comprising African swine fever virus proteins p30 and p54 fused to a cell-penetrating peptide

Authors: Guanglei Zhang, Wei Liu, Zhan Gao, Sicheng Yang, Guangqing Zhou, Yanyan Chang, Yunyun Ma, Xiaxia Liang, Junjun Shao, Huiyun Chang

Journal: Int Immunopharmacol

PubMed ID: 34715492

Doi: 10.1016/j.intimp.2021.108251

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Authors: J J David Ho, Tyler A Cunningham, Paola Manara, Caroline A Coughlin, Artavazd Arumov, Evan R Roberts, Ashanti Osteen, Preet Kumar, Daniel Bilbao, Jonathan R Krieger, Stephen Lee, Jonathan H Schatz

Journal: Cell Rep

PubMed ID: 34644561

Doi: 10.1016/j.celrep.2021.109806

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Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus)

Authors: Ting Liu, Ti-Lin Yi, Dai-Qin Yang, Ya-Xiong Tao

Journal: Gen Comp Endocrinol

PubMed ID: 34653433

Doi: 10.1016/j.ygcen.2021.113928

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Aquaglyceroporins and orthodox aquaporins in human adipocytes

Authors: Peng Huang, Jesper S Hansen, Karim H Saba, Anna Bergman, Florentina Negoita, Pontus Gourdon, Anna Hagström-Andersson, Karin Lindkvist-Petersson

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34627746

Doi: 10.1016/j.bbamem.2021.183795

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Characterization of SARS-CoV-2 Variants N501YV1 and N501YV2 Spike on Viral Infectivity

Authors: Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, F Xiao-Feng Qin

Journal: Front Cell Infect Microbiol

PubMed ID: 34722330

Doi: 10.3389/fcimb.2021.720357

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Authors: Nina Svensen, Susan Wyllie, David W Gray, Manu De Rycker

Journal: PLoS Negl Trop Dis

PubMed ID: 34634052

Doi: 10.1371/journal.pntd.0009870

Products & Services: Codon Optimization

Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Authors: Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Journal: Biochem J

PubMed ID: 34529035

Doi: 10.1042/BCJ20210041

Products & Services: Codon Optimization

Downregulation of the Tem1 GTPase by Amn1 after cytokinesis involves both nuclear import and SCF-mediated degradation

Authors: Alain Devault, Simonetta Piatti

Journal: J Cell Sci

PubMed ID: 34518877

Doi: 10.1242/jcs.258972

Products & Services: Recombinant Proteins

Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs

Authors: Hans Van der Weken, Raquel Sanz Garcia, Niek N Sanders, Eric Cox, Bert Devriendt

Journal: Front Immunol

PubMed ID: 34721427

Doi: 10.3389/fimmu.2021.753371

Products & Services: Gene Synthesis

GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

Authors: Bianca Calì, Andrielly H R Agnellini, Chiara Cioccarelli, Ricardo Sanchez-Rodriguez, Andrea Predonzani, Giulia Ilaria Toffolo, Antonella Viola, Vincenzo Bronte, Giorgio Arrigoni, Francesco Zonta, Laura Albertoni, Claudia Mescoli, Ilaria Marigo, Barbara Molon

Journal: Front Immunol

PubMed ID: 34675917

Doi: 10.3389/fimmu.2021.718098

Products & Services: Gene Synthesis

Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate

Authors: Wen-Hsiang Chen, Jeroen Pollet, Ulrich Strych, Jungsoon Lee, Zhuyun Liu, Rakhi Tyagi Kundu, Leroy Versteeg, Maria Jose Villar, Rakesh Adhikari, Junfei Wei, Cristina Poveda, Brian Keegan, Aaron Oakley Bailey, Yi-Lin Chen, Portia M Gillespie, Jason T Kimata, Bin Zhan, Peter J Hotez, Maria Elena Bottazzi

Journal: Protein Expr Purif

PubMed ID: 34688919

Doi: 10.1016/j.pep.2021.106003

Products & Services: Custom DNA/RNA Oligos

Cytotopic (Cyto-) IL-15 as a New Immunotherapy for Prostate Cancer: Recombinant Production in and Purification

Authors: Ana M Esteves, Efthymia Papaevangelou, Dorota Smolarek, Prokar Dasgupta, Christine Galustian

Journal: Front Mol Biosci

PubMed ID: 34778376

Doi: 10.3389/fmolb.2021.755764

Products & Services: Proteins, Expression, Isolation and Analysis

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble and During Aging

Authors: Maria Lucia Pigazzini, Mandy Lawrenz, Anca Margineanu, Gabriele S Kaminski Schierle, Janine Kirstein

Journal: Front Mol Neurosci

PubMed ID: 34720872

Doi: 10.3389/fnmol.2021.721749

Products & Services: Gene Synthesis

N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone

Authors: Karl D Brune, Ilva Liekniņa, Grigorij Sutov, Alexander R Morris, Dejana Jovicevic, Gints Kalniņš, Andris Kazāks, Rihards Kluga, Sabine Kastaljana, Anna Zajakina, Juris Jansons, Dace Skrastiņa, Karīna Spunde, Alexander A Cohen, Pamela J Bjorkman, Howard R Morris, Edgars Suna, Kaspars Tārs

Journal: Chembiochem

PubMed ID: 34520613

Doi: 10.1002/cbic.202100381

Products & Services: Peptide Synthesis

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Authors: Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky

Journal: PLoS Pathog

PubMed ID: 34648590

Doi: 10.1371/journal.ppat.1009967

Products & Services: Gene Synthesis

Deiodinase-3 is a thyrostat to regulate podocyte homeostasis

Authors: Shivangi Agarwal, Kwi Hye Koh, Nicholas J Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser

Journal: EBioMedicine

PubMed ID: 34649077

Doi: 10.1016/j.ebiom.2021.103617

Products & Services: Plasmid DNA Preparation

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice

Authors: Min-Wen Ku, Pierre Authié, Maryline Bourgine, François Anna, Amandine Noirat, Fanny Moncoq, Benjamin Vesin, Fabien Nevo, Jodie Lopez, Philippe Souque, Catherine Blanc, Ingrid Fert, Sébastien Chardenoux, Llta Lafosse, Delphine Cussigh, David Hardy, Kirill Nemirov, Françoise Guinet, Francina Langa Vives, Laleh Majlessi, Pierre Charneau

Journal: EMBO Mol Med

PubMed ID: 34647691

Doi: 10.15252/emmm.202114459

Products & Services: PCR and Cloning

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

Authors: Alex W Wessel, Michael P Doyle, Taylor B Engdahl, Jessica Rodriguez, James E Crowe, Michael S Diamond

Journal: MBio

PubMed ID: 34634945

Doi: 10.1128/mBio.02440-21

Products & Services: Mutagenesis Services

Low-Cost Optodiagnostic for Minute-Time Scale Detection of SARS-CoV-2

Authors: André Lopes Ferreira, Lucas Felipe de Lima, Marcelo Der Torossian Torres, William Reis de Araujo, Cesar de la Fuente-Nunez

Journal: ACS Nano

PubMed ID: 34669371

Doi: 10.1021/acsnano.1c03236

Products & Services: Mammalian Expression

Partial structure, dampened mobility, and modest impact of a His tag in the SARS-CoV-2 Nsp2 C-terminal region

Authors: Miguel Mompeán, Miguel Á Treviño, Douglas V Laurents

Journal: Eur Biophys J

PubMed ID: 34633480

Doi: 10.1007/s00249-021-01575-9

Products & Services: Gene Synthesis

Chromosome-Scale Genome and Comparative Transcriptomic Analysis Reveal Transcriptional Regulators of β-Carotene Biosynthesis in Mango

Authors: Xiaowei Ma, Xiang Luo, Yongzan Wei, Tuanhui Bai, Jiangli Shi, Bing Zheng, Wentian Xu, Li Li, Songbiao Wang, Jisen Zhang, Hongxia Wu

Journal: Front Plant Sci

PubMed ID: 34712262

Doi: 10.3389/fpls.2021.749108

Products & Services: Protein Tools

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

Authors: Deborah L Burnett, Katherine J L Jackson, David B Langley, Anupria Aggrawal, Alberto Ospina Stella, Matt D Johansen, Harikrishnan Balachandran, Helen Lenthall, Romain Rouet, Gregory Walker, Bernadette M Saunders, Mandeep Singh, Hui Li, Jake Y Henry, Jennifer Jackson, Alastair G Stewart, Franka Witthauer, Matthew A Spence, Nicole G Hansbro, Colin Jackson, Peter Schofield, Claire Milthorpe, Marianne Martinello, Sebastian R Schulz, Edith Roth, Anthony Kelleher, Sean Emery, Warwick J Britton, William D Rawlinson, Rudolfo Karl, Simon Schäfer, Thomas H Winkler, Robert Brink, Rowena A Bull, Philip M Hansbro, Hans-Martin Jäck, Stuart Turville, Daniel Christ, Christopher C Goodnow

Journal: Immunity

PubMed ID: 34788600

Doi: 10.1016/j.immuni.2021.10.019

Products & Services: Proteins, Expression, Isolation and Analysis

BDNF-Overexpressing Engineered Mesenchymal Stem Cells Enhances Their Therapeutic Efficacy against Severe Neonatal Hypoxic Ischemic Brain Injury

Authors: So Yoon Ahn, Dong Kyung Sung, Yun Sil Chang, Se In Sung, Young Eun Kim, Hyo-Jin Kim, Soon Min Lee, Won Soon Park

Journal: Int J Mol Sci

PubMed ID: 34768827

Doi: 10.3390/ijms222111395

Products & Services: PCR and Cloning

Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide

Authors: Gian Pietro Pietri, Marta Tontini, Barbara Brogioni, Davide Oldrini, Stefania Robakiewicz, Pedro Henriques, Ilaria Calloni, Vera Abramova, Laura Santini, Suzana Malić, Karmela Miklić, Berislav Lisnic, Sara Bertuzzi, Luca Unione, Evita Balducci, Jérôme de Ruyck, Maria Rosaria Romano, Jesus Jimenez-Barbero, Julie Bouckaert, Stipan Jonjic, Tihana Lenac Rovis, Roberto Adamo

Journal: Front Mol Biosci

PubMed ID: 34722634

Doi: 10.3389/fmolb.2021.745360

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MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain

Authors: Jie Zhang, Mengyuan Zhao, Run Yan, Jun Liu, Santhosh Maddila, Eunsung Junn, M Maral Mouradian

Journal: Neurotherapeutics

PubMed ID: 34697773

Doi: 10.1007/s13311-021-01130-6

Products & Services: PCR and Cloning

A plant reovirus hijacks the DNAJB12-Hsc70 chaperone complex to promote viral spread in its planthopper vector

Authors: Qifu Liang, Jiajia Wan, Huan Liu, Manni Chen, Taoran Xue, Dongsheng Jia, Qian Chen, Hongyan Chen, Taiyun Wei

Journal: Mol Plant Pathol

PubMed ID: 34668642

Doi: 10.1111/mpp.13152

Products & Services: PCR and Cloning

Cellular Effects of 2´,3´-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria

Authors: Yashasvika Duggal, Jennifer E Kurasz, Benjamin M Fontaine, Nick J Marotta, Shikha S Chauhan, Anna C Karls, Emily E Weinert

Journal: J Bacteriol

PubMed ID: 34662237

Doi: 10.1128/JB.00208-21

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Short-term immune response after inactivated SARS-CoV-2 (CoronaVac®, Sinovac) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-AstraZeneca) vaccinations in health care workers

Authors: Watsamon Jantarabenjakul, Napaporn Chantasrisawad, Thanyawee Puthanakit, Supaporn Wacharapluesadee, Nattiya Hirankarn, Vichaya Ruenjaiman, Leilani Paitoonpong, Gompol Suwanpimolkul, Pattama Torvorapanit, Rakchanok Pradit, Jiratchaya Sophonphan, Opass Putcharoen

Journal: Asian Pac J Allergy Immunol

PubMed ID: 34717527

Doi: 10.12932/AP-250721-1197

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes

Authors: Yingjuan J Lu, Leroy W Wheeler, Haiyan Chu, Paul J Kleindl, Michael Pugh, Fei You, Satish Rao, Gabriela Garcia, Henry Y Wu, Andre P da Cunha, Richard Johnson, Elaine Westrick, Vicky Cross, Alex Lloyd, Christina Dircksen, Patrick J Klein, Iontcho R Vlahov, Philip S Low, Christopher P Leamon

Journal: Cell Rep Med

PubMed ID: 34755134

Doi: 10.1016/j.xcrm.2021.100422

Products & Services: Mammalian Expression

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Authors: Sophie Sluysmans, Isabelle Méan, Tong Xiao, Amina Boukhatemi, Flavio Ferreira, Lionel Jond, Annick Mutero, Christopher J Chang, Sandra Citi

Journal: Mol Biol Cell

PubMed ID: 34613798

Doi: 10.1091/mbc.E21-07-0355

Products & Services: Molecular Biology Tools

Limited impact of Delta variantâ€™s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: medrxiv

PubMed ID: 34729566

Doi: 10.1101/2021.10.25.21265422

Products & Services: Recombinant Proteins

Rational engineering of a functional CpG-free ITR for AAV gene therapy

Authors: Xiufang Pan, Yongping Yue, Maria Boftsi, Lakmini P Wasala, Ngoc Tam Tran, Keqing Zhang, David J Pintel, Phillip W L Tai, Dongsheng Duan

Journal: Gene Ther

PubMed ID: 34611321

Doi: 10.1038/s41434-021-00296-0

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Comprehensive Analysis of Transcriptome-wide mA Methylome Upon Beta2 Toxin Exposure in Porcine Intestinal Epithelial Cells by mA Sequencing

Authors: Juanli Zhang, Qiaoli Yang, Jiaojiao Yang, Xiaoli Gao, Ruirui Luo, Xiaoyu Huang, Zunqiang Yan, Pengfei Wang, Wei Wang, Kaihui Xie, Bo Zhang, Shuangbao Gun

Journal: Front Genet

PubMed ID: 34737761

Doi: 10.3389/fgene.2021.689748

Products & Services: Proteins, Expression, Isolation and Analysis

Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria

Authors: Yanping Zhang, Han Xiao, Qiuhong Xiong, Changxin Wu, Ping Li

Journal: Int J Mol Sci

PubMed ID: 34681668

Doi: 10.3390/ijms222011008

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Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma

Authors: Mari K Halle, Aishwarya Sundaresan, Jianqing Zhang, Chandra Sekhar Pedamallu, Vinodh Srinivasasainagendra, Jessica Blair, Dewey Brooke, Bjørn I Bertelsen, Kathrine Woie, Sadeep Shrestha, Hemant Tiwari, Yick Fu Wong, Camilla Krakstad, Akinyemi I Ojesina

Journal: NPJ Genom Med

PubMed ID: 34620846

Doi: 10.1038/s41525-021-00244-2

Products & Services: Gene Synthesis

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice

Authors: Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi

Journal: PeerJ

PubMed ID: 34721976

Doi: 10.7717/peerj.12285

Products & Services: Plasmid DNA Preparation

Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

Authors: Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M Gruntman, Guangping Gao, Terence R Flotte, Allison M Keeler

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34853797

Doi: 10.1016/j.omtm.2021.10.010

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Programmable nano-reactors for stochastic sensing

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yuming Gu, Guangrui Qian, Xiaoyu Du, Liying Wang, Yao Liu, Jiao Cao, Shanyu Zhang, Shuanghong Yan, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: Nat Commun.

PubMed ID: 34608151

Doi: 10.1038/s41467-021-26054-9

Products & Services: Single-Stranded DNA Synthesis

Structural basis of the P4B ATPase lipid flippase activity

Authors: Lin Bai, Bhawik K Jain, Qinglong You, H Diessel Duan, Mehmet Takar, Todd R Graham, Huilin Li

Journal: Nat Commun

PubMed ID: 34645814

Doi: 10.1038/s41467-021-26273-0

Products & Services: Proteins, Expression, Isolation and Analysis

Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study

Authors: Raffaele Marfella, Nunzia D'Onofrio, Celestino Sardu, Lucia Scisciola, Paolo Maggi, Nicola Coppola, Ciro Romano, Vincenzo Messina, Fabrizio Turriziani, Mario Siniscalchi, Mauro Maniscalco, Marco Boccalatte, Giovanni Napolitano, Luigi Salemme, Ludovica Vittoria Marfella, Eugenio Basile, Maria Vittoria Montemurro, Carmela Papa, Francesco Frascaria, Antonio Papa, Ferdinando Russo, Virginia Tirino, Gianpaolo Papaccio, Marilena Galdiero, Ferdinando Carlo Sasso, Michelangela Barbieri, Maria Rosaria Rizzo, Maria Luisa Balestrieri, Italo Francesco Angelillo, Claudio Napoli, Giuseppe Paolisso

Journal: Diabetes Obes Metab

PubMed ID: 34494705

Doi: 10.1111/dom.14547

Products & Services: Serology SARS-Cov-2 detection kits

Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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Effect of Structural Changes Induced by Deletion of 54FLRAPSWF61 Sequence in αB-Crystallin on Chaperone Function and Anti-Apoptotic Activity

Authors: Sundararajan Mahalingam, Srabani Karmakar 1ORCID, Puttur Santhoshkumar, Krishna K. Sharma

Journal: International Journal of Molecular Sciences

PubMed ID: 34639110

Doi: 10.3390/ijms221910771

Products & Services: Proteins, Expression, Isolation and Analysis

Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells

Authors: Daria S Chulpanova, Zarema E Gilazieva, Elvira R Akhmetzyanova, Sevindzh K Kletukhina, Albert A Rizvanov, Valeriya V Solovyeva

Journal: Tissue Cell

PubMed ID: 34678531

Doi: 10.1016/j.tice.2021.101664

Products & Services: PCR Cloning and Subcloning

Quantitative comparison of different fluorescent dye-loaded nanoparticles

Authors: Guangze Yang, Yun Liu, Chun-Xia Zhao

Journal: Colloids Surf B Biointerfaces

PubMed ID: 34146992

Doi: doi.org/10.1016/j.colsurfb.2021.111923

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Transgenic genome editing-derived antiviral therapy to nucleopolyhedrovirus infection in the industrial strain of the silkworm

Authors: Xu Yang, Xiaoqian Zhang, Yujia Liu, Dehong Yang, Zulian Liu, Kai Chen, Linmeng Tang, Manli Wang, Zhihong Hu, Shengxiang Zhang, Yongping Huang

Journal: Insect Biochem Mol Biol

PubMed ID: 34700022

Doi: 10.1016/j.ibmb.2021.103672

Products & Services: GenCrispr Cas9 Genome Editing

Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells

Authors: Chuanzhao Yu, Haiwen Zhong, Xiaohui Yang, Guoling Li, Zhenfang Wu, Huaqiang Yang

Journal: Biotechnol J

PubMed ID: 34705337

Doi: 10.1002/biot.202100408

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Tong‑fu‑li‑fei decoction attenuates immunosuppression to protect the intestinal‑mucosal barrier in sepsis by inhibiting the PD‑1/PD‑L1 signaling pathway

Authors: Li Chen, Lan Li, Suzhao Zou, Qianhua Liao, Bo Lv

Journal: Mol Med Rep

PubMed ID: 34633052

Doi: 10.3892/mmr.2021.12480

Products & Services: Nucleic Acid Purification & Analysis

Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2

Authors: Ren-Lei Ji, Lu Huang, Yin Wang, Ting Liu, Si-Yu Fan, Min Tao, Ya-Xiong Tao

Journal: Endocr Connect

PubMed ID: 34678761

Doi: 10.1530/EC-21-0459

Products & Services: Nucleic Acid Purification & Analysis

Determining folding and binding properties of the C-terminal SH2 domain of SHP2

Authors: Caterina Nardella, Francesca Malagrinò, Livia Pagano, Serena Rinaldo, Stefano Gianni, Angelo Toto

Journal: Protein Sci

PubMed ID: 34605082

Doi: 10.1002/pro.4201

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Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

Authors: Dong-Ho Jo, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Yu-Min Kang, Kang-Won Choe, Kwang-Nam Kim

Journal: Vaccines (Basel)

PubMed ID: 34696253

Doi: 10.3390/vaccines9101145

Products & Services: Mammalian Expression

Structural basis of cytokine-mediated activation of ALK family receptors

Authors: Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J Fernando Bazan, Akihide Yoshimi, Savvas N Savvides

Journal: Nature

PubMed ID: 34646012

Doi: 10.1038/s41586-021-03959-5

Products & Services: Mammalian Expression

Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients

Authors: Jonathan Marable, Damien Ruiz, Anil K Jaiswal, Ritankar Bhattacharya, Robert Pantazes, Payal Agarwal, Amol S Suryawanshi, Deepa Bedi, Amarjit Mishra, Bruce F Smith, Maninder Sandey

Journal: Sci Rep

PubMed ID: 34675296

Doi: 10.1038/s41598-021-00325-3

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The Small Metal-Binding Protein SmbP Simplifies the Recombinant Expression and Purification of the Antimicrobial Peptide LL-37

Authors: David A Perez-Perez, Teresa de J Villanueva-Ramirez, Adriana E Hernandez-Pedraza, Nestor G Casillas-Vega, Patricia Gonzalez-Barranco, Xristo Zarate

Journal: Antibiotics (Basel)

PubMed ID: 34680851

Doi: 10.3390/antibiotics10101271

Products & Services: DNA Sequencing Gene Synthesis

Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells

Authors: Yishan Ge, Wenwu Liu, Wei Yin, Xuebin Wang, Jie Wang, Xiaoqing Zhu, Shengkai Xu

Journal: Bioengineered

PubMed ID: 34637670

Doi: 10.1080/21655979.2021.1989260

Products & Services: DNA Sequencing

Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism

Authors: Edem Gavor, Yeu Khai Choong, Chacko Jobichen, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Protein Sci

PubMed ID: 34658092

Doi: 10.1002/pro.4212

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ChimLeish, a new recombinant chimeric protein evaluated as a diagnostic and prognostic marker for visceral leishmaniasis and human immunodeficiency virus coinfection

Authors: Nathalia C Galvani, Amanda S Machado, Daniela P Lage, Camila S Freitas, Danniele L Vale, Daysiane de Oliveira, Fernanda Ludolf, Fernanda F Ramos, Bruna B Fernandes, Gabriel P Luiz, Débora V C Mendonça, João A Oliveira-da-Silva, Thiago A R Reis, Grasiele S V Tavares, Ana T Chaves, Nathalia S Guimarães, Unaí Tupinambás, Gláucia F Cota, Maria V Humbert, Vívian T Martins, Myron Christodoulides, Eduardo A F Coelho, Ricardo A Machado-de-Ávila

Journal: Parasitol Res

PubMed ID: 34664113

Doi: 10.1007/s00436-021-07342-1

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Discovery of a novel glucuronan lyase system in

Authors: Bo Pilgaard, Marlene Vuillemin, Line Munk, Jesper Holck, Sebastian Meier, Casper Wilkens, Anne S Meyer

Journal: Appl Environ Microbiol

PubMed ID: 34705548

Doi: 10.1128/AEM.01819-21

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Analysis of IgG, IgA and IgM antibodies against SARS-CoV-2 spike protein S1 in convalescent and vaccinated patients with the Pfizer-BioNTech and CanSinoBio vaccines

Authors: Edgar A Melgoza-González, Diana Hinojosa-Trujillo, Mónica Reséndiz-Sandoval, Verónica Mata-Haro, Sofía Hernández-Valenzuela, Melissa García-Vega, Marlene Bravo-Parra, Aldo A Arvizu-Flores, Olivia Valenzuela, Edgar Velázquez, Alan Soto-Gaxiola, Martha B Gómez-Meza, Fernando Pérez-Jacobo, Luis Villela, Jesús Hernández

Journal: Transbound Emerg Dis

PubMed ID: 34655457

Doi: 10.1111/tbed.14344

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Optimizing -Mediated Transformation and CRISPR-Cas9 Gene Editing in the Rice Variety Presidio

Authors: Marco Molina-Risco, Oneida Ibarra, Mayra Faion-Molina, Backki Kim, Endang M Septiningsih, Michael J Thomson

Journal: Int J Mol Sci

PubMed ID: 34681568

Doi: 10.3390/ijms222010909

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CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation

Authors: Xiaohan Mei, Xiao-Bing Cui, Yiran Li, Shi-You Chen

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34670409

Doi: 10.1161/ATVBAHA.121.316911

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A Novel Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase

Authors: Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Antonio Mattia Modarelli, Matteo Bertelli, Leonardo Colombo, Daniele Dell'Orco

Journal: Int J Mol Sci

PubMed ID: 34639157

Doi: 10.3390/ijms221910809

Products & Services: Custom Vector Construction Gene Synthesis

The membrane associated accessory protein is an adeno-associated viral egress factor

Authors: Zachary C Elmore, L Patrick Havlik, Daniel K Oh, Leif Anderson, George Daaboul, Garth W Devlin, Heather A Vincent, Aravind Asokan

Journal: Nat Commun

PubMed ID: 34716331

Doi: 10.1038/s41467-021-26485-4

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Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1

Authors: Yan Li, Elizabeth YiHui Ng, Ying Ru Loh, Chong Yu Gea, Qiwei Huang, Qingxin Li, CongBao Kang

Journal: J Pept Sci

PubMed ID: 34713534

Doi: 10.1002/psc.3376

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Advances in Universal CAR-T Cell Therapy

Authors: Haolong Lin, Jiali Cheng, Wei Mu, Jianfeng Zhou, Li Zhu

Journal: Front Immunol

PubMed ID: 34691052

Doi: 10.3389/fimmu.2021.744823

Products & Services: CRISPR Libraries

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Authors: Quanli Liu, Yi Liu, Gang Li, Otto Savolainen, Yun Chen, Jens Nielsen

Journal: Nat Commun

PubMed ID: 34667183

Doi: 10.1038/s41467-021-26361-1

Products & Services: Codon Optimization

CRISPR/Cas12a-assisted rapid identification of key beer spoilage bacteria

Authors: Qingzhou Menga, Hongmei Yangb, Guiquan Zhangc, Wenjun Sund, Peixiang Mae, Xinyi Liuf, Lu Dangg, Guanglei Lid, Xingxu Huangd, Xinjie Wangh, Jianghuai Liuc, Qibin Lenga

Journal: Innovative Food Science and Emerging Technologies

Doi: 10.1016/j.ifset.2021.102854

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NIN-like protein transcription factors regulate leghemoglobin genes in legume nodules

Authors: Suyu Jiang, Marie-Françoise Jardinaud, Jinpeng Gao, Yann Pecrix, Jiangqi Wen,b Kirankumar Mysore, Ping Xu, Carmen Sanchez-Canizares, Yiting Ruan, Qiujiu Li, Meijun Zhu, Fuyu Li, Ertao Wang, Phillip S Poole, Pascal Gamas, Jeremy D Murray

Journal: Science

PubMed ID: 34709882

Doi: 10.1126/science.abg5945

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An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein

Authors: Narasimha Anaganti, Sujith Rajan, M Mahmood Hussain

Journal: J Lipid Res

PubMed ID: 34673018

Doi: 10.1016/j.jlr.2021.100136

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Construction and Analysis of a Yeast for the Simultaneous Release and Esterification of the Varietal Thiol 3-Sulfanylhexan-1-ol

Authors: Florian Kiene, Isak S Pretorius, Doris Rauhut, Christian von Wallbrunn, Niël van Wyk

Journal: J Agric Food Chem

PubMed ID: 34609136

Doi: 10.1021/acs.jafc.1c03976

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Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma

Authors: Sakiko Harada, Miki Ando, Jun Ando, Midori Ishii, Tomoyuki Yamaguchi, Satoshi Yamazaki, Tokuko Toyota, Kazuo Ohara, Manami Ohtaka, Mahito Nakanishi, Chansu Shin, Yasunori Ota, Kazutaka Nakashima, Koichi Ohshima, Chihaya Imai, Yozo Nakazawa, Hiromitsu Nakauchi, Norio Komatsu

Journal: Mol Ther

PubMed ID: 34628050

Doi: 10.1016/j.ymthe.2021.10.006

Products & Services: Recombinant Antibody Expression

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

Authors: Matthias Liniger, Markus Gerber, Sandra Renzullo, Obdulio García-Nicolás, Nicolas Ruggli

Journal: Viruses

PubMed ID: 34696447

Doi: 10.3390/v13102017

Products & Services: Proteins, Expression, Isolation and Analysis

Corrigendum to "Rapid preparation of nanodiscs for biophysical studies" [Arch Biochem Biophys 712 (2021) 109051]

Authors: Jeffrey A Julien, Martin G Fernandez, Katrina M Brandmier, Joshua T Del Mundo, Carol M Bator, Lucie A Loftus, Esther W Gomez, Enrique D Gomez, Kerney Jebrell Glover

Journal: Arch Biochem Biophys

PubMed ID: 34756727

Doi: 10.1016/j.abb.2021.109073

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

Authors: Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang

Journal: J Med Chem

PubMed ID: 34668699

Doi: 10.1021/acs.jmedchem.1c01076

Products & Services: Proteins, Expression, Isolation and Analysis

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Authors: Shuang-Zhou Peng, Xiao-Hui Chen, Si-Jie Chen, Jie Zhang, Chuan-Ying Wang, Wei-Rong Liu, Duo Zhang, Ying Su, Xiao-Kun Zhang

Journal: Nat Commun

PubMed ID: 34645818

Doi: 10.1038/s41467-021-26295-8

Products & Services: Proteins, Expression, Isolation and Analysis

Evidence of a shared binding site for Bacillus thuringiensis Cry1Ac and Cry2Aa toxins in Cnaphalocrocis medinalis cadherin

Authors: J Zhong, S Fang, M Gao, L Lu, X Zhang, Q Zhu, Y Liu, J L Jurat-Fuentes, X Liu

Journal: Insect Mol Biol

PubMed ID: 34637177

Doi: 10.1111/imb.12741

Products & Services: Proteins, Expression, Isolation and Analysis

Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways

Authors: Sean T Carey, Joshua M Gammon, Christopher M Jewell

Journal: Drug Deliv Transl Res

PubMed ID: 34611846

Doi: 10.1007/s13346-021-01075-5

Products & Services: Proteins, Expression, Isolation and Analysis

Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine

Authors: Danielle L Porier, Sarah N Wilson, Dawn I Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C Allen, Clayton C Caswell, James A Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C Weaver, Albert J Auguste

Journal: Vaccines (Basel)

PubMed ID: 34696250

Doi: 10.3390/vaccines9101142

Products & Services: Plasmid DNA Preparation

L-asparaginase from : expression, purification and cytotoxicity assessment

Authors: Hesham Saeed, Eman Elsawy, Manal Shalaby, Manal Abdel-Fattah, Asmaa Hemida, Ahmad Eldoksh, Farid Shokry Ataya, Hesham Nematalla, Mohamed Elkewedi, Nikolaos N Labrou, Nefertiti El-Nikhely

Journal: Prep Biochem Biotechnol

PubMed ID: 34612174

Doi: 10.1080/10826068.2021.1983831

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Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation

Authors: Patrick N Charron, Luis M Garcia, Irfan Tahir, Rachael A Floreani

Journal: J Mech Behav Biomed Mater

PubMed ID: 34736027

Doi: 10.1016/j.jmbbm.2021.104932

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