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A Necroptosis-Related Prognostic Model of Uveal Melanoma Was Constructed by Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases

Authors: Jiaheng Xie, Liang Chen, Qikai Tang, Wei Wei, Yuan Cao, Chuyan Wu, Jing Hang, Kai Zhang, Jingping Shi, Ming Wang

Journal: Front Immunol

PubMed ID: 35242144

Doi: 10.3389/fimmu.2022.847624

Products & Services: Custom DNA/RNA Oligos

Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering

Authors: Andreas Santamaria, Krishna C Batchu, Olga Matsarskaia, Sylvain F Prévost, Daniela Russo, Francesca Natali, Tilo Seydel, Ingo Hoffmann, Valérie Laux, Michael Haertlein, Tamim A Darwish, Robert A Russell, Giacomo Corucci, Giovanna Fragneto, Armando Maestro, Nathan R Zaccai

Journal: J Am Chem Soc

PubMed ID: 35157798

Doi: 10.1021/jacs.1c09856

Products & Services: Peptide Synthesis

High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors: Rosa Maria Chura-Chambi, Alvaro Rossan de Brandão Prieto-da-Silva, Matheus Martins Di Lela, João Ezequiel Oliveira, Patricia Estima Antonia Abreu, Luciana Regina Meireles, Heitor Franco de Andrade Junior, Ligia Morganti

Journal: PLoS ONE

PubMed ID: 35113919

Doi: 10.1371/journal.pone.0262591

Products & Services: Protein and Antibody Isolation

Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: Sci Transl Med

PubMed ID: 35166573

Doi: 10.1126/scitranslmed.abn8057

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Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine

Authors: Sayoni Ray, David M Wirth, Oscar A Ortega-Rivera, Nicole F Steinmetz, Jonathan K Pokorski

Journal: Biomacromolecules

PubMed ID: 35139303

Doi: 10.1021/acs.biomac.1c01345

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Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor

Authors: Hongmao Sun, Nathan P Coussens, Carina Danchik, Leah M Wachsmuth, Mark J Henderson, Samarjit Patnaik, Matthew D Hall, Ashley L Molinaro, Dayle A Daines, Min Shen

Journal: J Chem Inf Model

PubMed ID: 35103473

Doi: 10.1021/acs.jcim.1c01188

Products & Services: Recombinant Antibody Expression

Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics

Authors: Simon D Weaver, Naviya Schuster-Little, Rebecca J Whelan

Journal: Anal Methods

PubMed ID: 35175250

Doi: 10.1039/d1ay02145a

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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability

Authors: Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian

Journal: Bioengineered

PubMed ID: 35081868

Doi: 10.1080/21655979.2021.2024962

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Challenges of expressing recombinant human tissue factor as a secreted protein in

Authors: Mohammad Jalili-Nik, Mohammad Soukhtanloo, Majid Mojarrad, Mohammad Hadi Sadeghian, Baratali Mashkani

Journal: Prep Biochem Biotechnol

PubMed ID: 35133942

Doi: 10.1080/10826068.2021.2023823

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Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

Products & Services: Protein Tools

Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

Products & Services: Mutant Libraries

Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

Products & Services: Mutant Libraries

Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Authors: Gail Brenda Cross, Claire M Naftalin, Jinghao Nicholas Ngiam, Natasha Bagdasarian, Chek Meng Poh, Yun Shan Goh, Wan Ni Chia, Siti Naqiah Amrun, Sai Meng Tham, Hazel Teng, Rawan Alagha, Shoban Krishna Kumar, Shaun Shi Yan Tan, Lin Fa Wang, Paul Anantharajah Tambyah, Laurent Renia, Dale Fisher, Lisa F P Ng

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

Products & Services: Recombinant Antibody Expression

Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

Products & Services: Gene Fragments

Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

Products & Services: Recombinant Proteins

Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2

Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger

Journal: Vaccines (Basel)

PubMed ID: 35214780

Doi: 10.3390/vaccines10020322

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High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

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SARS-CoV-2 neutralizing capacity among blood donors without prior COVID-19 symptomatic history vs blood donors with prior COVID-19 symptomatic history: A comparative study

Authors: Ushasree Ravula, Srinivasa Rao Chunchu, Srujaleswari Mooli, Ravi Naik, Pandu Ranga Rao Sarangapati

Journal: Transfus Clin Biol

PubMed ID: 35167958

Doi: 10.1016/j.tracli.2022.02.004

Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol

PubMed ID: 35231466

Doi: 10.1016/j.dci.2022.104379

Products & Services: Recombinant Antibody Expression

Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S Manola, Panagiotis Malandrakis, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Biomedicines

PubMed ID: 35203547

Doi: 10.3390/biomedicines10020338

The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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Fitness benefits play a vital role in the retention of the Pi-ta susceptible alleles

Authors: Jia Liu, Suobing Zhang, Pengfei Xie, Long Wang, Jia-Yu Xue, Yanmei Zhang, Ruisen Lu, Yueyu Hang, Yue Wang, Xiaoqin Sun

Journal: Genetics

PubMed ID: 35143673

Doi: 10.1093/genetics/iyac019

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Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases

Authors: Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer, Alisa Markgraf, Philine Falk, Jakob Reich, Friedrich Riess, Philipp Girl, Katharina Müller, Katja Radon, Jessica Michelle Guggenbuehl Noller, Roman Wölfel, Michael Hoelscher, Inge Kroidl, Andreas Wieser, Laura Olbrich

Journal: Virology

PubMed ID: 35245784

Doi: 10.1016/j.virol.2022.02.002

Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles

Authors: Yifei Yang, Zhenning Sun, Huopeng Li, Jijing Tian, Mingyong Chen, Tianlong Liu

Journal: Nanomaterials (Basel)

PubMed ID: 35214924

Doi: 10.3390/nano12040595

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Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles

Authors: Yifei Yang, Zhenning Sun, Huopeng Li, Jijing Tian, Mingyong Chen, Tianlong Liu

Journal: Nanomaterials (Basel)

PubMed ID: 35214924

Doi: 10.3390/nano12040595

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RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells

Authors: Weijiang Wu, Zhe Wang, Zhijian Zhang, Wenjing Yang, Xin Fan, Jili Xu, Zhiqiang Huang, Qixiang Shao

Journal: Cell Tissue Bank

PubMed ID: 35147838

Doi: 10.1007/s10561-022-09994-4

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Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells

Authors: Weijiang Wu, Zhe Wang, Zhijian Zhang, Wenjing Yang, Xin Fan, Jili Xu, Zhiqiang Huang, Qixiang Shao

Journal: Cell Tissue Bank

PubMed ID: 35147838

Doi: 10.1007/s10561-022-09994-4

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Circular dichroism spectroscopic assessment of structural changes upon protein thermal unfolding at contrasting pH: Comparison with molecular dynamics simulations

Authors: Ponciano García-Gutiérrez, Menandro Camarillo-Cadena, Liliana I Vera-Robles, Rafael A Zubillaga, Andrés Hernández-Arana

Journal: Spectrochim Acta A Mol Biomol Spectrosc

PubMed ID: 35245803

Doi: 10.1016/j.saa.2022.121039

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Structural characterization of the ANTAR antiterminator domain bound to RNA

Authors: James L Walshe, Rezwan Siddiquee, Karishma Patel, Sandro F Ataide

Journal: Nucleic Acids Res

PubMed ID: 35150565

Doi: 10.1093/nar/gkac074

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Structural characterization of the ANTAR antiterminator domain bound to RNA

Authors: James L Walshe, Rezwan Siddiquee, Karishma Patel, Sandro F Ataide

Journal: Nucleic Acids Res

PubMed ID: 35150565

Doi: 10.1093/nar/gkac074

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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Authors: Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries

Journal: Front Mol Biosci

PubMed ID: 35211509

Doi: 10.3389/fmolb.2022.811116

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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines

Authors: Noëmi Johanna Roos, Riccardo Vincenzo Mancuso, Gerda Mawududzi Sanvee, Jamal Bouitbir, Stephan Krähenbühl

Journal: Food Chem Toxicol

PubMed ID: 35182693

Doi: 10.1016/j.fct.2022.112869

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Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

Authors: Huaying Zhao; Ai Nguyen; Di Wu; Yan Li; Sergio A. Hassan; Jiji Chen; Hari Shroff; Grzegorz Piszczek; Peter Schuck

Journal: biorxiv

PubMed ID: 35169797

Doi: 10.1101/2022.02.08.479556

Engineered bacterial host for genetic encoding of physiologically stable protein nitration

Authors: Nikolaj G Koch, Tobias Baumann, Jessica H Nickling, Anna Dziegielewski, Nediljko Budisa

Journal: Front Mol Biosci

PubMed ID: 36353730

Doi: 10.3389/fmolb.2022.992748

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Reactivity of DENV-positive sera against recombinant envelope proteins produced in bacteria and eukaryotic cells

Authors: Higo Fernando Santos Souza, Arthur Baruel Zaneti, Bianca da Silva Almeida, Jéssica Amaral Martinho, Márcio Massao Yamamoto, Daniela Santoro Rosa, Renata Denzegrini Slhessarenko, Silvia Beatriz Boscardin

Journal: Immunol Res

PubMed ID: 36192522

Doi: 10.1007/s12026-022-09326-4

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Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

Authors: Sanjib K Mukherjee, Jim-Marcel Knop, Roland Winter

Journal: Chemistry

PubMed ID: 34882862

Doi: 10.1002/chem.202104182

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A model for DHX15 mediated disassembly of A-complex spliceosomes

Authors: Hannah M Maul-Newby, Angela N Amorello, Turvi Sharma, John H Kim, Matthew S Modena, Beth E Prichard, Melissa S Jurica

Journal: RNA

PubMed ID: 35046126

Doi: 10.1261/rna.078977.121

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Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Authors: Rhia Kundu, Janakan Sam Narean, Lulu Wang, Joseph Fenn, Timesh Pillay, Nieves Derqui Fernandez, Emily Conibear, Aleksandra Koycheva, Megan Davies, Mica Tolosa-Wright, Seran Hakki, Robert Varro, Eimear McDermott, Sarah Hammett, Jessica Cutajar, Ryan S Thwaites, Eleanor Parker, Carolina Rosadas, Myra McClure, Richard Tedder, Graham P Taylor, Jake Dunning, Ajit Lalvani

Journal: Nat Commun

PubMed ID: 35013199

Doi: 10.1038/s41467-021-27674-x

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Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria

Authors: Karol M Córdoba, Irantzu Serrano-Mendioroz, Daniel Jericó, María Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, María J Garrido, Paolo G V Martini, José Luis Lanciego, Jesús Prieto, Pedro Berraondo, Antonio Fontanellas

Journal: Sci Transl Med

PubMed ID: 35020410

Doi: 10.1126/scitranslmed.abc0700

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Physicochemical Characterization and In Vitro Digestibility Study of an In Silico Designed Recombinant Protein Enriched with Large Neutral Amino Acids and Lacking Phenylalanine for Phenylketonuria

Authors: Prakruthi Appaiah, L Sunil, Asha Martin, Prasanna Vasu

Journal: Protein J

PubMed ID: 35064867

Doi: 10.1007/s10930-021-10039-0

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Enzymatic synthesis of cellulose in space: gravity is a crucial factor for building cellulose II gel structure

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: Cellulose (Lond)

PubMed ID: 35125685

Doi: 10.1007/s10570-021-04399-0

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Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor

Authors: Longying Jiang, Xueke Liu, Hudie Wei, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Yongheng Chen

Journal: Biochem Biophys Res Commun

PubMed ID: 35091108

Doi: 10.1016/j.bbrc.2022.01.069

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Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Authors: Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B Weiner, Kate Broderick, Bin Wang

Journal: Hum Vaccin Immunother

PubMed ID: 35061975

Doi: 10.1080/21645515.2021.2016201

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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Authors: Enquan Xu, Ravindra Boddu, Hisham A Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M Carlisle, Elliot J Lefkowitz, Ashley S Harms, Etty N Benveniste, Talene A Yacoubian, Laura A Volpicelli-Daley, David G Standaert, Andrew B West

Journal: Mol Neurodegener

PubMed ID: 35012605

Doi: 10.1186/s13024-021-00509-5

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Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

Authors: Kylie M Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Himanshi Chawla, Jianqiu Du, Nicholas J Tursi, Alan Moore, Jared Adolf-Bryfogle, Mansi Purwar, Emma L Reuschel, Drew Frase, Matthew Sullivan, Benjamin Fry, Igor Maricic, Viviane M Andrade, Christel Iffland, Max Crispin, Kate E Broderick, Laurent M P F Humeau, Ami Patel, Trevor R F Smith, Jesper Pallesen, David B Weiner, Daniel W Kulp

Journal: Cell Rep

PubMed ID: 35090597

Doi: 10.1016/j.celrep.2022.110318

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Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection

Authors: Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D Tapia, J Kristie Johnson, Samba O Sow, Joshua T Thaden, Vance G Fowler, Karen A Krogfelt, Annelie Brauner, Efthymia Protonotariou, Eirini Christaki, Yuichiro Shindo, Andrea L Kwa, Sadia Shakoor, Ashika Singh-Moodley, Olga Perovic, Jan Jacobs, Octavie Lunguya, Raphael Simon, Alan S Cross, Sharon M Tennant

Journal: BMC Microbiol

PubMed ID: 34991476

Doi: 10.1186/s12866-021-02427-4

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Identification of a plant endophytic growth-promoting bacteria capable of inhibiting cadmium uptake in rice

Authors: Wei Tian, Le Li, Xiao Xiao, Huili Wu, Yulong Wang, Zhaoyang Hu, Nahmina Begum, Yiping Zou, Laiqing Lou, Ming Chang, Qingsheng Cai

Journal: J Appl Microbiol

PubMed ID: 34216530

Doi: 10.1111/jam.15201

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Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

Authors: Grega Popovic, Nicholas C Kirby, Taylor C Dement, Kristine M Peterson, Caroline E Daub, Heather A Belcher, Martin Guthold, Adam R Offenbacher, Nathan E Hudson

Journal: Int J Mol Sci

PubMed ID: 35162976

Doi: 10.3390/ijms23031054

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FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape

Authors: Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li

Journal: Theranostics

PubMed ID: 34976216

Doi: 10.7150/thno.66575

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CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors

Authors: Daniela Nasif, Sebastian Real, María Roqué, María T Branham

Journal: Breast Cancer

PubMed ID: 35094293

Doi: 10.1007/s12282-022-01334-4

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MPP1 Determines the Mobility of Flotillins and Controls the Confinement of Raft-Associated Molecules

Authors: Agnieszka Biernatowska, Karolina Wójtowicz, Tomasz Trombik, Aleksander F Sikorski, Aleksander Czogalla

Journal: Cells

PubMed ID: 35159121

Doi: 10.3390/cells11030311

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Nanobody-based anti-CD22-chimeric antigen receptor T cell immunotherapy exhibits improved remission against B-cell acute lymphoblastic leukemia

Authors: Tingting Zhang, Tian Wang, Fengtao You, Zixuan Li, Dan Chen, Kailu Zhang, Shuaiyu Tian, Binjie Sheng, Hai Wu, Licui Jiang, Renyuxue Ma, Gangli An, Huimin Meng, Lin Yang

Journal: Transpl Immunol

PubMed ID: 35051588

Doi: 10.1016/j.trim.2022.101538

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Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workers

Authors: Maria Nikolova, Yana Todorova, Radoslava Emilova, Iva Trifonova, Teodora Gladnishka, Nina Petrova-Yancheva, Tatyana Chervenyakova, Elena Dragusheva, Georgi Popov, Iva Christova

Journal: J Med Virol

PubMed ID: 34997611

Doi: 10.1002/jmv.27572

A Novel Potent Carrier for Unconventional Protein Export in

Authors: Magnus Philipp, Kai P Hussnaetter, Michèle Reindl, Kira Müntjes, Michael Feldbrügge, Kerstin Schipper

Journal: Front Cell Dev Biol

PubMed ID: 35083222

Doi: 10.3389/fcell.2021.816335

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Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Authors: Anusyah Rathakrishnan, Samuel Connell, Vlad Petrovan, Katy Moffat, Lynnette C Goatley, Tamara Jabbar, Pedro J Sánchez-Cordón, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 35044212

Doi: 10.1128/jvi.01899-21

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Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding

Authors: Natalie Jay, Sean R Duffy, D Fernando Estrada

Journal: Biochemistry

PubMed ID: 34979083

Doi: 10.1021/acs.biochem.1c00770

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The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release

Authors: Mila M Paul, Sven Dannhäuser, Lydia Morris, Achmed Mrestani, Martha Hübsch, Jennifer Gehring, Georgios N Hatzopoulos, Martin Pauli, Genevieve M Auger, Grit Bornschein, Nicole Scholz, Dmitrij Ljaschenko, Martin Müller, Markus Sauer, Hartmut Schmidt, Robert J Kittel, Aaron DiAntonio, Ioannis Vakonakis, Manfred Heckmann, Tobias Langenhan

Journal: Brain

PubMed ID: 35022694

Doi: 10.1093/brain/awac011

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Highly efficient A-to-G base editing by ABE8.17 in rabbits

Authors: Ding Zhao , Yuqiang Qian , Jinze Li , Zhanjun Li , Liangxue Lai

Journal: Mol Ther Nucleic Acids .

PubMed ID: 35282412

Doi: 10.1016/j.omtn.2022.01.019

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Expression, purification and characterization of the suppressor of copper sensitivity (Scs) B membrane protein from Proteus mirabilis

Authors: Russell J Jarrott, Emily J Furlong, Guillaume A Petit, David Drew, Jennifer L Martin, Maria A Halili

Journal: Protein Expr Purif

PubMed ID: 35026386

Doi: 10.1016/j.pep.2022.106047

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Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to regulate TORC1 signaling

Authors: Shreya Goyal, Verónica A Segarra, Aaron M Stetcher, Andrew W Truman, Adam M Reitzel, Richard J Chi

Journal: Traffic

PubMed ID: 35098628

Doi: 10.1111/tra.12833

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Sterility of Sustained-release Buprenorphine

Authors: Shraddha I Cantara, Crystal Gergye, Vanessa K Lee, Michael Huerkamp

Journal: J Am Assoc Lab Anim Sci

PubMed ID: 35082006

Doi: 10.30802/AALAS-JAALAS-21-000105

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Blue-light receptor phototropin 1 suppresses immunity to promote Phytophthora infestans infection

Authors: Shaista Naqvi, Qin He, Franziska Trusch, Huishan Qiu, Jasmine Pham, Qingguo Sun, John M Christie, Eleanor M Gilroy, Paul R J Birch

Journal: New Phytol

PubMed ID: 34923631

Doi: 10.1111/nph.17929

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Investigation of putative antimicrobial peptides in Carassius gibel, revealing a practical approach to screening antimicrobials

Authors: Yujun Zhang, Ping Deng, Caijiao Dai, Mengke Wu, Xueqin Liu, Lijuan Li, Xiaoyi Pan, Junfa Yuan

Journal: Fish Shellfish Immunol

PubMed ID: 34990806

Doi: 10.1016/j.fsi.2021.12.050

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Core-shell "loading-type" nanomaterials towards: Simultaneous imaging analysis of glutathione and microRNA

Authors: Lin-Lin Lu, Qin Zhang, Yu Gu, Xiang-Ling Li, Jing Jing Xie

Journal: Anal Chim Acta

PubMed ID: 35151402

Doi: 10.1016/j.aca.2022.339551

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Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses

Authors: Bo Wang, Shuang Li, Yongbo Qiao, Yu Fu, Jiaojiao Nie, Shun Jiang, Xin Yao, Yi Pan, Linye Zhao, Congmei Wu, Yuhua Shi, Yuhe Yin, Yaming Shan

Journal: J Nanobiotechnology

PubMed ID: 35012571

Doi: 10.1186/s12951-021-01229-0

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Nitroreduction of flutamide by NADPH: Cytochrome P450 reductase

Authors: Mohd Faheem Khan, Cormac D Murphy

Journal: Biochem Biophys Rep

PubMed ID: 35097225

Doi: 10.1016/j.bbrep.2022.101209

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Nitroreduction of flutamide by NADPH: Cytochrome P450 reductase

Authors: Mohd Faheem Khan, Cormac D Murphy

Journal: Biochem Biophys Rep

PubMed ID: 35097225

Doi: 10.1016/j.bbrep.2022.101209

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Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates

Authors: Xi Liu, Shuliu Dai, Yu Zhou, Jinyue Liu, Dong Li, Jun Zhang, Yushan Zhu, Qiao Zhao, Yue Feng, Yi Zhang

Journal: Biochem Biophys Res Commun

PubMed ID: 35066379

Doi: 10.1016/j.bbrc.2022.01.037

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Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates

Authors: Xi Liu, Shuliu Dai, Yu Zhou, Jinyue Liu, Dong Li, Jun Zhang, Yushan Zhu, Qiao Zhao, Yue Feng, Yi Zhang

Journal: Biochem Biophys Res Commun

PubMed ID: 35066379

Doi: 10.1016/j.bbrc.2022.01.037

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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Authors: Zhengqi Zha, Yaoyao Liu, Yinghua Miao, Shiying Liao, Su-Yan Wang, Huiling Tang, Hongping Yin

Journal: Int J Biol Macromol

PubMed ID: 34998873

Doi: 10.1016/j.ijbiomac.2021.12.098

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Degradation of dimethachlon by a newly isolated bacterium Paenarthrobacter sp strain JH-1 relieves its toxicity against Chlorella ellipsoidea

Authors: Mingliang Zhang, Wankui Jiang, Siyuan Gao, Qian Zhu, Zhijian Ke, Mingli Jiang, Jiguo Qiu, Qing Hong

Journal: Environ Res

PubMed ID: 35031339

Doi: 10.1016/j.envres.2022.112706

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Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis

Authors: Qian Guo, Tingting Guo, Yuanyuan Sun, Tianrong Chen

Journal: Neuroreport

PubMed ID: 34874325

Doi: 10.1097/WNR.0000000000001743

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Bio-nanocapsules for oriented immobilization of DNA aptamers on aptasensors

Authors: Masumi Iijima, Yuki Yamada, Hideo Nakano, Tsutomu Nakayama, Shun'ichi Kuroda

Journal: Analyst

PubMed ID: 35023508

Doi: 10.1039/d1an02278d

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Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test

Authors: Qiao Wang, Lili Feng, Haohai Zhang, Juehua Gao, Changchuin Mao, Esther Landesman-Bollag, Gustavo Mostoslavsky, Justin M Lunderberg, Weina Zheng, Shushun Hao, Wenda Gao

Journal: Antib Ther

PubMed ID: 35146332

Doi: 10.1093/abt/tbac004

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Involvement of β-cyanoalanine synthase (β-CAS) and sulfurtransferase (ST) in cyanide (CN) assimilation in rice seedlings

Authors: Yu-Xi Feng, Cheng-Zhi Li, Yu-Juan Lin, Xiao-Zhang Yu

Journal: Chemosphere

PubMed ID: 35101430

Doi: 10.1016/j.chemosphere.2022.133789

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Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence

Authors: Stefano Perni, Kurt Beam