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Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1
Authors: Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I Goldhaber, Riccardo Olcese, Michela Ottolia
Journal: Nat Commun
PubMed ID: 38714663
Doi: 10.1038/s41467-024-47850-z
Evolution of a novel adrenal cell type that promotes parental care
Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky
Journal: Nature
PubMed ID: 38750354
Doi: 10.1038/s41586-024-07423-y
Products & Services: Molecular Biology Reagents   
Context dependent activity of p63-bound gene regulatory elements
Authors: Abby A McCann, Gabriele Baniulyte, Dana L Woodstock, Morgan A Sammons
Journal: biorxiv
PubMed ID: 38766006
Doi: 10.1101/2024.05.09.593326
Products & Services: Gene Synthesis   
Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice
Authors: Xiaoshuang Liu, Dongfang Gu, Yiru Zhang, Yingli Jiang, Zhi Xiao, Rongfang Xu, Ruiying Qin, Juan Li, Pengcheng Wei
Journal: Genome Biol
PubMed ID: 38773623
Doi: 10.1186/s13059-024-03282-y
Products & Services: Gene Synthesis   
Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
Authors: Jiaqi Fu, Siying Li, Hongxin Guan, Chuang Li, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu, Lei Song, Songying Ouyang, Zhao-Qing Luo
Journal: Res Sq
PubMed ID: 38826349
Doi: 10.21203/rs.3.rs-4431542/v1
Products & Services: Codon Optimization   
Characterization of Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate
Authors: Sizhong Feng, Mengke Xue, Fang Xie, Hongyang Zhao, Yemin Xue
Journal: J Agric Food Chem
PubMed ID: 38753963
Doi: 10.1021/acs.jafc.4c01973
Products & Services: Gene Synthesis   
Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility
Authors: Zhenyu Liu, Huayi Liu, Chaoqun Huang, Qun Zhou, Yunzi Luo
Journal: ACS Synth Biol
PubMed ID: 38819403
Doi: 10.1021/acssynbio.4c00103
Bazi Bushen alleviates reproductive aging in aged male mice
Authors: Kun Ma, Mengnan Li, Yahui Song, Xinjing Mao, Shaolan Zhang, Yaping Zhang, Yuning Jiang, Chuanyuan Ji, Kunxu Niu, Hongrong Li, Yunlong Hou, Cong Wei
Journal: Chin J Nat Med
PubMed ID: 38796215
Doi: 10.1016/S1875-5364(24)60639-4
Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae)
Authors: Kui Hu, Rong Jin, Jianqi Liu, Jun Zhu, Wei Dai, Ying Wang, Yao Li, Fang Liu
Journal: J Econ Entomol
PubMed ID: 38783398
Doi: 10.1093/jee/toae113
Products & Services: Catalog Antibody   
Virus-like particle-based multipathogen vaccine of FMD and SVA elicits balanced and broad protective efficacy in mice and pigs
Authors: Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo
Journal: Vaccine
PubMed ID: 38714448
Doi: 10.1016/j.vaccine.2024.04.092
Products & Services: Molecular Biology Reagents   
POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway
Authors: Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng
Journal: Am J Cancer Res
PubMed ID: 38859843
Doi: 10.62347/JEWM7691
Products & Services: Molecular Biology Reagents   
Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests
Authors: Janessa D Lewis , Stephen J Salipante
Journal: J Clin Microbiol
PubMed ID: 38629844
Doi: 10.1128/jcm.00243-24
Products & Services: Gene Synthesis   
CRISPR/Cas13a-based supersensitive circulating tumor DNA assay for detecting EGFR mutations in plasma
Authors: Li Wang , Xiaosha Wen , Yang Yang , Zheng Hu , Jing Jiang , Lili Duan , Xiaofen Liao , Yan He , Yaru Liu , Jing Wang , Zhikun Liang , Xiaoya Zhu , Quan Liu , Tiancai Liu , Dixian Luo
Journal: Commun Biol
PubMed ID: 38806596
Doi: 10.1038/s42003-024-06368-2
Products & Services: Plasmid DNA Preparation   
Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity
Authors: Min Wu, Guangping Song, Jianing Li, Zengqing Song, Bing Zhao, Liyun Liang, Wenlong Li, Huaibin Hu, Haiqing Tu, Sen Li, Peiyao Li, Biyu Zhang , Wen Wang, Yu Zhang , Wanpeng Zhang, Weifan Zheng, Jiarong Wang, Yuqi Wen, Kai Wang, Ailing Li, Tao Zhou, Yucheng Zhang, Huiyan Li
Journal: Cell
Doi: 10.1016/j.cell.2024.04.027
Products & Services: Catalog Peptides   
The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation
Authors: Joanne Saldanha , Julie Rageul , Jinal A Patel , Amy L Phi , Natalie Lo , Jennifer J Park , Hyungjin Kim
Journal: Nucleic Acids Res
PubMed ID: 38801073
Doi: 10.1093/nar/gkae445.
Products & Services: PCR Cloning and Subcloning   
Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes
Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12
Journal: J Hepatol
PubMed ID: 38782119
Doi: doi: 10.1016/j.jhep.2024.05.016.
Products & Services: Mutagenesis Services   
Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis
Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao
Journal: Int J Biol Macromol
PubMed ID: 38801850
Doi: 10.1016/j.ijbiomac.2024.132667
Products & Services: Molecular Biology Reagents   
but not is the avirulence determinant in melon carrying the resistance against watermelon mosaic virus, although they contain a common genetic determinant
Authors: Zhen Sun, Yu-Xuan Wu, Ling-Zhi Liu, Yan-Ping Tian, Xiang-Dong Li, Chao Geng
Journal: J Virol
PubMed ID: 38775482
Doi: 10.1128/jvi.00507-24
Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir
Authors: Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang, Yaxue Yang, Danyang Li, Biao Yang, Kaiting Gao, Zhengyu Zhang, Changjiang Dong
Journal: Int J Biol Macromol
PubMed ID: 38735603
Doi: 10.1016/j.ijbiomac.2024.132231
Earliest records of the Asian longhorned tick (Acari: Ixodidae) in Staten Island, New York, and subsequent population establishment, with a review of its potential medical and veterinary importance in the United States
Authors: Waheed Bajwa, Ashley Kennedy, Zachary Vincent, Garrett Heck, Shamim Riaj, Zahir Shah, Leonid Tsynman, Cory Casal, Scott Haynes, Hannah Cornman, Andrea Egizi, Ellen Stromdahl, Robyn Nadolny
Journal: J Med Entomol
PubMed ID: 38412407
Doi: 10.1093/jme/tjae019
Nonclinical Evaluation of Single-Mutant Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses
Authors: Grace Ruiz-Lara, Tales A Costa-Silva, Jorge Javier Muso-Cachumba, Johanna Cevallos Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, Carlota de Oliveira Rangel-Yagui, Gisele Monteiro
Journal: Int J Mol Sci
PubMed ID: 38892196
Doi: 10.3390/ijms25116008
Products & Services: Codon Optimization   
Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies
Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M Falkowski, Thomas G Biel, Tongzhong Ju, Wen Jin Wu
Journal: Front Immunol
PubMed ID: 38863707
Doi: 10.3389/fimmu.2024.1376096
A "One-Step" Strategy for the Global Characterization of Core-Fucosylated Glycoproteome
Authors: Yuqiu Wang, Rui Yuan, Bo Liang, Jing Zhang, Qin Wen, Hongxu Chen, Yinping Tian, Liuqing Wen, Hu Zhou
Journal: JACS Au
PubMed ID: 38818065
Doi: 10.1021/jacsau.4c00214
Products & Services: Molecular Biology Reagents   
Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease
Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn
Journal: Heliyon
PubMed ID: 38867992
Doi: 10.1016/j.heliyon.2024.e31987
Products & Services: Serology SARS-Cov-2 detection kits   
Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo
Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin
Journal: Eur J Pharmacol
PubMed ID: 38754534
Doi: 10.1016/j.ejphar.2024.176647
Products & Services: Molecular Biology Reagents   
Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury
Authors: Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu
Journal: CNS Neurosci Ther
PubMed ID: 38715283
Doi: 10.1111/cns.14742
YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway
Authors: Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan
Journal: Sci Rep
PubMed ID: 38714727
Doi: 10.1038/s41598-024-61157-5
Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010
Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu
Journal: Int J Mol Sci
PubMed ID: 38791440
Doi: 10.3390/ijms25105402
Products & Services: Gene Synthesis   
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies
Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman
Journal: Nat Commun
PubMed ID: 38816420
Doi: 10.1038/s41467-024-49000-x
Products & Services: Molecular Biology Reagents   
Functional Characterization of F3H Gene and Optimization of Dihydrokaempferol Biosynthesis in
Authors: Qinyi Chen, Dandan Song, Xiaoyan Sun, Yulong Tian, Zecheng Yan, Ting Min, Hongxun Wang, Limei Wang
Journal: Molecules
PubMed ID: 38792058
Doi: 10.3390/molecules29102196
Products & Services: Codon Optimization   
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses
Authors: Ze-Zheng Jiang, Min Chu, Li-Na Yan, Wen-Kang Zhang, Bang Li, Jiao Xu, Zhong-Xin Zhao, Hui-Ju Han, Chuan-Min Zhou, Xue-Jie Yu
Journal: Microbiol Spectr
PubMed ID: 38712963
Doi: 10.1128/spectrum.03796-23
Products & Services: Molecular Biology Reagents   
Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat
Authors: Yayu Chen, Gen Wei, Lieliang Zhang, Xiaojin Feng, Enjun Lei
Journal: Exp Neurol
PubMed ID: 38823674
Doi: 10.1016/j.expneurol.2024.114842
Products & Services: Gene Synthesis   
Preparation and epitope analysis of monoclonal antibodies against African swine fever virus DP96R protein
Authors: Chao Li, Xuan-Ying Si, Xiao-Ge Wang, Zhi-Wei Yan, Hao-Yu Hou, Long-Qi You, Yin-Long Chen, Ang-Ke Zhang, Na Wang, Ai-Jun Sun, Yong-Kun Du, Gai-Ping Zhang
Journal: BMC Vet Res
PubMed ID: 38734611
Doi: 10.1186/s12917-024-04043-6
Products & Services: Gene Synthesis   
Computational design of non-porous pH-responsive antibody nanoparticles
Authors: Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z. Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King & David Baker
Journal: Nat Struct Mol Biol
PubMed ID: 38724718
Doi: 10.1038/s41594-024-01288-5
Products & Services: Gene Synthesis   
A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila
Authors: Alka Singh, Kandahalli Venkataranganayaka Abhilasha, Kathya R. Acharya, Haibo Liu, Niraj K. Nirala, Velayoudame Parthibane, Govind Kunduri, Thiruvaimozhi Abimannan, Jacob Tantalla, Lihua Julie Zhu, Jairaj K. Acharya & Usha R. Acharya
Journal: Nat Commun
PubMed ID: 38782979
Doi: 10.1038/s41467-024-48851-8
Products & Services: PCR Cloning and Subcloning   
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis
Authors: Julia Zibold, Lola E R Lessard, Flavien Picard, Lara Gruijs da Silva, Yelyzaveta Zadorozhna, Nathalie Streichenberger, Edwige Belotti, Alexis Osseni, Andréa Emerit, Elisabeth Errazuriz-Cerda, Laurence Michel-Calemard, Rita Menassa, Laurent Coudert, Manuela Wiessner, Rolf Stucka, Thomas Klopstock, Francesca Simonetti, Saskia Hutten, Takashi Nonaka, Masato Hasegawa, Tim M Strom, Emilien Bernard, Elisabeth Ollagnon, Andoni Urtizberea, Dorothee Dormann, Philippe Petiot, Laurent Schaeffer, Jan Senderek, Pascal Leblanc
Journal: Brain
PubMed ID: 38079474
Doi: 10.1093/brain/awad410
Products & Services: Mutagenesis Services   
The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction
Authors: Xiaopan Gao, Bei Wang, Kaixiang Zhu, Linyue Wang, Bo Qin, Kun Shang, Wei Ding, Jianwei Wang & Sheng Cui
Journal: Nat Commun
PubMed ID: 38755176
Doi: 10.1038/s41467-024-48504-w
Products & Services: Gene Synthesis   
The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress
Authors: Sivamathini Rajappa, Pannaga Krishnamurthy, Hua Huang, Dejie Yu, Jiří Friml, Jian Xu & Prakash P. Kumar
Journal: Nat Commun
PubMed ID: 38729926
Doi: 10.1038/s41467-024-48234-z
Products & Services: Mutagenesis Services   
Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding
Authors: Wojciech Jankowski, Stepan S. Surov, Nancy E. Hernandez, Atul Rawal, Marcos Battistel, Daron Freedberg, Mikhail V. Ovanesov & Zuben E. Sauna
Journal: Nat Commun
PubMed ID: 38724509
Doi: 10.1038/s41467-024-48278-1
Products & Services: Gene Synthesis   
Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity
Authors: Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao & Yang Mao
Journal: Nat Commun
PubMed ID: 38755139
Doi: 10.1038/s41467-024-48503-x
Products & Services: Catalog Antibody   
Tracking single-cell evolution using clock-like chromatin accessibility loci
Authors: Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang & Yi Zhang
Journal: Nature Biotechnol
PubMed ID: 38724668
Doi: 10.1038/s41587-024-02241-z
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Oriented immobilization of antibodies through peptide ligands for ultrasensitive detection of gastrin 17 in human serum via lateral flow immunoassay
Authors: Xintong Li , Jiale Cui , Jin Li , Yulian Wang , Guoqing Shi
Journal: Microchemical Journal
Doi: j.microc.2024.110819
Products & Services: Peptide Synthesis   
Semi-rational design for enhancing thermostability of Culex pipiens acetylcholinesterase and sensitivity analysis of acephate
Authors: Shuoqi Jiang, Zhuangwei Zhang, Qiuya Gu, Xiaobin Yu
Journal: Sci Total Environ
PubMed ID: 38759926
Doi: 10.1016/j.scitotenv.2024.173282
MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells
Authors: Yanmiao Dai, Yudong Xu, Jie Shen, Caihong Hu, Xiaoli Li, Yongyu Chen, Yao Liu, Duanmin Hu
Journal: Exp Cell Res
PubMed ID: 38802035
Doi: 10.1016/j.yexcr.2024.114099
Products & Services: Custom DNA/RNA Oligos   
Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy
Authors: Chuan Chen, Zehua Sun, Zening Wang, Seungmin Shin, Abigail Berrios, John W Mellors, Dimiter S Dimitrov, Wei Li
Journal: Antibodies (Basel)
PubMed ID: 38804307
Doi: 10.3390/antib13020039
Tardigrade secretory proteins protect biological structures from desiccation
Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver
Journal: Commun Biol
PubMed ID: 38796644
Doi: 10.1038/s42003-024-06336-w
Kinetic Characterization and Identification of Key Active Site Residues of the L-Aspartate N-Hydroxylase, CreE
Authors: Sydney B Johnson, Hannah Valentino, Pablo Sobrado
Journal: Chembiochem
PubMed ID: 38775737
Doi: 10.1002/cbic.202400350
Products & Services: Molecular Biology Reagents   
Structural Determinants of FeoB Nucleotide Promiscuity
Authors: Mark Lee, Kate Magante, Camilo Gómez-Garzón, Shelley M Payne, Aaron T Smith
Journal: biorxiv
PubMed ID: 38826458
Doi: 10.1101/2024.05.22.595361
Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses
Authors: Emily Bettini, Aleksey Chudnovskiy, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Diana Castaño, Joy Chiu, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Zoltan Lipinszki, Ivan Maillard, Ying K Tam, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci
Journal: biorxiv
PubMed ID: 38798523
Doi: 10.1101/2024.05.17.594726
Products & Services: Gene Synthesis   
SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress
Authors: Shuaiyang Jing, Jingkai Gao, Neeraj Tiwari, Yulei Du, Lianhui Zhu, Bopil Gim, Yi Qian, Xihua Yue, Intaek Lee
Journal: Commun Biol
PubMed ID: 38710927
Doi: 10.1038/s42003-024-06232-3

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