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Regulating the N-oxidation selectivity of P450BM3 monooxygenases for N-heterocycles through computer-assisted structure-guided design

Authors: Liu Yang, Zhongji Pu, Jianping Wu, Xiaofeng Liu, Zhe Wang, Haoran Yu, Liuwei Wang, Yan Meng, Gang Xu, Lirong Yang, Wenlong Zheng

Journal: Nature Communications

PubMed ID: 40659637

Doi: 10.1038/s41467-025-61773-3

Products & Services: Protein Electrophoresis and Western

Regulation of inflammatory responses by pH-dependent transcriptional condensates

Authors: Zhongyang Wu, Scott D Pope, Nasiha S Ahmed, Diana L Leung, Yu Hong, Stephanie Hajjar, Cathleen Krabak, Zhe Zhong, Krishnan Raghunathan, Qiuyu Yue, Diya M Anand, Elizabeth B Kopp, Daniel Okin, Weiyi Ma, Ivan Zanoni, Jonathan C Kagan, Jay R Thiagarajah, Diana C Hargreaves, Ruslan Medzhitov, Xu Zhou

Journal: Cell

PubMed ID: 40680734

Doi: 10.1016/j.cell.2025.06.033

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Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates

Authors: Nita Patel, Asma Rehman, Jessica F Trost, Rhonda Flores, Zach Longacre, Mimi Guebre-Xabier, Haixia Zhou, Bin Zhou, Kelsey Jacobson, Desheng Jiang, Xiaoyun Bai, Rafia Khatoon, Thomas Kort, James Norton, M Madhangi, Melinda Hersey, Ann M Greene, Filip Dubovsky, Gale Smith

Journal: Nature Communications

PubMed ID: 40681543

Doi: 10.1038/s41467-025-61964-y

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Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination

Authors: Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang

Journal: Advanced Science

PubMed ID: 40681479

Doi: 10.1002/advs.202413014

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Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles

Authors: Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin

Journal: Interdisciplinary Materials

Doi: doi.org/10.1002/idm2.70000

Products & Services: Protein Electrophoresis and Western

A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao

Journal: Advanced Science

PubMed ID: 40685690

Doi: 10.1002/advs.202509419

Products & Services: Protein and Antibody Isolation

ZEB2 is a master switch controlling the tumor-associated macrophage program

Authors: Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher-Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan, Kiara Freitag, Ido Yofe, Vladimir Yutkin, Pierre Boyeau, Can Ergen, Justin Hong, Kfir Mazuz, Yuxiao Liu, Kangming Chen, Rony Dahan, Marcin Kortylewski, Nir Yosef, Assaf Weiner, Ido Amit

Journal: Cancer Cell

PubMed ID: 40215981

Doi: 10.1016/j.ccell.2025.03.021

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Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma

Authors: Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue

Journal: ACS Nano

PubMed ID: 40698543

Doi: 10.1021/acsnano.5c08928

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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

Authors: Chen Guo, Zhilin Long, Peng Lin, Yinan Shen, Yiye Zhong, Jingjing Qian, Jichuan Yu, Weixi Zhao, Fuyi Liu, Yiling Ma, Jian Zheng, Jiayao Yang, Shuai Zhao, Xiaojuan Ran, Zhen Xia, Congying Wu, Yujia Cai, Chen Wang, Qi Xie

Journal: Cell Reports Medicine

PubMed ID: 40744020

Doi: 10.1016/j.xcrm.2025.102258

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Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice

Authors: Prem Kumar Govindappa, Govindaraj Ellur, John P Hegarty, Akash Gupta, Rahul V G, John C Elfar

Journal: Cell death & disease

PubMed ID: 40610400

Doi: 10.1038/s41419-025-07825-4

Products & Services: Protein Electrophoresis and Western

Engineering precision zebrafish alleles of human disease

Authors: Holly R. Thomas; Bradley K. Yoder; Matthew S. Alexander; John M. Parant

Journal: biorxiv

PubMed ID: 40475461

Doi: 10.1101/2025.05.18.654701

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CONSTANT PH MOLECULAR DYNAMICS OF PORCINE CIRCOVIRUS 2 CAPSID PROTEIN REVEALS A MECHANISM FOR CAPSID ASSEMBLY

Authors: Elvira Tarasova; Noriaki Okimoto; Shanshan Feng; Dmitry Nerukh; Reza Khayat; Makoto Taiji

Journal: Physical chemistry chemical physics : PCCP

PubMed ID: 34726674

Doi: 10.1039/d1cp02874j

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CONSTANT PH MOLECULAR DYNAMICS OF PORCINE CIRCOVIRUS 2 CAPSID PROTEIN REVEALS A MECHANISM FOR CAPSID ASSEMBLY

Authors: Elvira Tarasova; Noriaki Okimoto; Shanshan Feng; Dmitry Nerukh; Reza Khayat; Makoto Taiji

Journal: Physical chemistry chemical physics : PCCP

PubMed ID: 34726674

Doi: 10.1039/d1cp02874j

Products & Services: Plasmid DNA Preparation

CONSTANT PH MOLECULAR DYNAMICS OF PORCINE CIRCOVIRUS 2 CAPSID PROTEIN REVEALS A MECHANISM FOR CAPSID ASSEMBLY

Authors: Elvira Tarasova; Noriaki Okimoto; Shanshan Feng; Dmitry Nerukh; Reza Khayat; Makoto Taiji

Journal: Physical chemistry chemical physics : PCCP

PubMed ID: 34726674

Doi: 10.1039/d1cp02874j

Products & Services: Plasmid DNA Preparation

Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C -lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab )

Authors: Rachel A. Powers; Bradley J. Wallar; Hannah R. Jarvis; Zoe X. Ziegler; Cynthia M. June; Christopher R. Bethel; Andrea M. Hujer; Magdalena A. Taracila; Susan D. Rudin; Kristine M. Hujer; Fabio Prati; Emilia Caselli; Robert A. Bonomo

Journal: MBio

PubMed ID: 40377322

Doi: 10.1128/mbio.00287-25

Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Authors: Austin Tedman; Muskan Goel; Sohan Shah; Mathew K. Howard; Laura M. Chamness; Antonio Bonifasi; Ismalia Adams; Jacklyn M. Gallagher; Wesley D. Penn; Katarina Nemec; Eli F. McDonald; Brianna N. Corman; J. Paul Robinson; Carol Beth Post; Patricia L. Clark; M. Madan Babu; Aashish Manglik; Charles P. Kuntz; Willow Coyote-Maestas; Jonathan P. Schlebach

Journal: biorxiv

PubMed ID: 41000614

Doi: 10.1101/2025.09.19.677468

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

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Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy

Authors: Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu

Journal: Nature Communications

PubMed ID: 40593574

Doi: 10.1038/s41467-025-60819-w

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Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules

Authors: Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein

Journal: Nature Communications

PubMed ID: 40593800

Doi: 10.1038/s41467-025-61306-y

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A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma

Authors: Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J Katris, Yoshiki Yamaryo-Botté, Cyrille Y Botté

Journal: Nature Communications

PubMed ID: 40595705

Doi: 10.1038/s41467-025-61155-9

Rim4-seeded stress granules connect temperature sensing to meiotic regulation

Authors: Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang

Journal: Nature Communications

PubMed ID: 40593583

Doi: 10.1038/s41467-025-60645-0

Products & Services: Protein Electrophoresis and Western

Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia

Authors: Xiayi Liao, Chun-Yu Tung, Jocelyn F Krey, Ghazaleh Behnammanesh, Joseph A Cirilo Jr, Mert Colpan, Christopher M Yengo, Peter G Barr-Gillespie, Jonathan E Bird, Benjamin J Perrin

Journal: Nature Communications

PubMed ID: 40593742

Doi: 10.1038/s41467-025-60976-y

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Pol θ-mediated end-joining uses microhomologies containing mismatches

Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood

Journal: Nature Communications

PubMed ID: 40603872

Doi: 10.1038/s41467-025-61258-3

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Structural-functional characterization of the MIRO1-TRAK1 complex

Authors: Erika E Ravitch, Elana E Baltrusaitis, Tania A Perez, Kyle R Barrie, Adam R Fenton, Erika L F Holzbaur, Roberto Dominguez

Journal: Nature Communications

PubMed ID: 40615373

Doi: 10.1038/s41467-025-61174-6

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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Authors: Markéta Novotná, Michele Tinti, Joana R C Faria, David Horn

Journal: Nature Communications

PubMed ID: 40615444

Doi: 10.1038/s41467-025-61480-z

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FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka

Journal: SCIENCE ADVANCES

PubMed ID: 40601736

Doi: 10.1126/sciadv.adu9104

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Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner

Journal: Nature Communications

PubMed ID: 40617823

Doi: 10.1038/s41467-025-61498-3

Products & Services: Mammalian Expression

Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system

Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl

Journal: Nature Communications

PubMed ID: 40617857

Doi: 10.1038/s41467-025-61671-8

Products & Services: Gene Synthesis

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

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Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Protein and Antibody Isolation

The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens

Authors: Antonella Falconieri, Giulia Boarolo, Chiara Boschelle, Giovanni Spagnolli, Caterina Marchioretti, Emanuela Zuccaro, Isabella Palazzolo, Laura Tosatto, Adham Kamaleldeen Omara Hegazy, Jessica Rosati, Kenneth Fischbeck, Manuela Basso, Hans Christoph Liedtke, Ivan Gomez-Mestre, Luisa Dalla Valle, Emiliano Biasini, Pietro Faccioli, Alessandro Grapputo, Maria Pennuto

Journal: Nucleic acids research

PubMed ID: 40682815

Doi: 10.1093/nar/gkaf688

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Extracellular CIRP dysregulates microglial efferocytosis in ischemic stroke via the TLR4/miR-155/MafB axis

Authors: Dmitriy Lapin; Dilara Aylar; Archna Sharma; Ping Wang

Journal: research square

PubMed ID: 40766256

Doi: 10.21203/rs.3.rs-7223452/v1

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Engineering precision zebrafish alleles of human disease

Authors: Holly R. Thomas; Bradley K. Yoder; Matthew S. Alexander; John M. Parant

Journal: biorxiv

PubMed ID: 40475461

Doi: 10.1101/2025.05.18.654701

Products & Services: Molecular Biology Reagents

The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM

Authors: Emil Gustavsson; Kay Gr newald; Per Elias; B Martin H llberg

Journal: Nucleic Acids Research

PubMed ID: 41125242

Doi: 10.1093/nar/gkaf1029

Visualization of a multi-turnover Cas9 after product release

Authors: Kaitlyn A. Kiernan & David W. Taylor

Journal: Nature Communications

PubMed ID: 40593576

Doi: 10.1038/s41467-025-60668-7

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Molecular architecture and catalytic mechanism of human glycogen debranching enzyme

Authors: Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

Journal: Nature Communications

PubMed ID: 40593796

Doi: 10.1038/s41467-025-61077-6

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Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Authors: Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N Savvides, Xavier Saelens

Journal: Nature Communications

PubMed ID: 40593518

Doi: 10.1038/s41467-025-60232-3

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Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Authors: Amanda X Y Chen, Kah Min Yap, Joelle S Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A Dunbar, Volker Wiebking, Jesse D Armitage, Isabelle Munoz, Kirsten L Todd, Emily B Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X Hoang, Katherine M Audsley, Marit J van Elsas, Jim Middelburg, Joel N Lee, Maria N de Menezes, Thomas J Cole, Jasmine Li, Christina Scheffler, Andrew M Scott, Laura K Mackay, Jason Waithman, Jane Oliaro, Simon J Harrison, Ian A Parish, Junyun Lai, Matthew H Porteus, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature

PubMed ID: 40604285

Doi: 10.1038/s41586-025-09212-7

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A single main-chain hydrogen bond required to keep GABAA receptors closed

Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Journal: Nature Communications

PubMed ID: 40603861

Doi: 10.1038/s41467-025-61447-0

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NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis

Authors: Ann-Kristin Dicke, Ammar Ahmedani, Lin Ma, Leonie Herrmann, Godfried W van der Heijden, Sophie A Koser, Claudia Krallmann, Oguzhan Kalyon, Miguel J Xavier, Joris A Veltman, Sabine Kliesch, Nina Neuhaus, Noora Kotaja, Frank Tüttelmann, Birgit Stallmeyer

Journal: Nature Communications

PubMed ID: 40624043

Doi: 10.1038/s41467-025-61463-0

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Nucleosome spacing can fine-tune higher-order chromatin assembly

Authors: Lifeng Chen, M Julia Maristany, Stephen E Farr, Jinyue Luo, Bryan A Gibson, Lynda K Doolittle, Jorge R Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, Michael K Rosen

Journal: Nature Communications

PubMed ID: 40628730

Doi: 10.1038/s41467-025-61482-x

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Ion channel structure and function of the MERS coronavirus E protein

Authors: Iva Sučec, Bingqing Xia, Noah H Somberg, Yi Wang, Hyunil Jo, Shuangqu Li, Barbara Perrone, Zhaobing Gao, Mei Hong

Journal: SCIENCE ADVANCES

PubMed ID: 40632851

Doi: 10.1126/sciadv.adx1788

Products & Services: PCR Cloning and Subcloning

Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity

Authors: Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui

Journal: Advanced Science

PubMed ID: 40642785

Doi: 10.1002/advs.202501727

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Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury

Authors: Zhiqiang Zhao, Xinzhu Shan, Jing Ding, Bin Ma, Buyao Li, Wendi Huang, Qingqing Yang, Yian Fang, Junhe Chen, Chenglin Song, Chenlong Wei, Shuai Liu, Xingdi Cheng, Shengran Zhang, Yunxuan Liu, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu, Lei Miao

Journal: Nature Communications

PubMed ID: 40659631

Doi: 10.1038/s41467-025-61688-z

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Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout

Authors: Ludmila A Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V Verkhusha

Journal: Nature Communications

PubMed ID: 40659617

Doi: 10.1038/s41467-025-61532-4

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Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice

Authors: Zhiyuan Li, Zheng Tian, Xiaoliu Shi, Aijun Long, Yazhuo Wang, Yan Yang, Yaqi Wang, Jingjing Zhang, Yiguo Wang

Journal: Nature Communications

PubMed ID: 40670400

Doi: 10.1038/s41467-025-61963-z

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Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Authors: Hui Yuan 1, Pengcheng Xiao 2, Wei Huang 2, Wenguo Cui 1

Journal: Advanced Science

PubMed ID: 40667608

Doi: 10.1002/advs.202504319

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Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ

Authors: K S Beckwith, Ø Ødegård-Fougner, N R Morero, C Barton, F Schueder, W Tang, S Alexander, J-M Peters, R Jungmann, E Birney, J Ellenberg

Journal: Nature Communications

PubMed ID: 40683887

Doi: 10.1038/s41467-025-61689-y

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Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

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