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Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

Antimicrobial and Potent Anti- Biofilm Properties of Rationally Designed α- Helix Antimicrobial Peptides

Authors: Motasim Ismael, Khayeli Juliah, Madivoli Edwin

Journal: Journal of Peptide Science

PubMed ID: 40326595

Doi: 10.1002/psc.70027

Products & Services: Peptide Synthesis

Control of seed-to-seedling transition by an upstream open reading frame in ABSCISIC ACID DEFICIENT2

Authors: Zhen Wang , Xiaofan Zhang ， Can Zhou , Xiaofeng Cao

Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PubMed ID: 40478869

Doi: 10.1073/pnas.2502155122

Products & Services: Gene Synthesis

Collective Biosynthesis of Plant Spirooxindole Alkaloids through Enzyme Discovery and Engineering

Authors: Danni Chu, Hongkui Wang, Zhiwen Nie, Kang-Li Li, Jiaqing Cao, Meijing Yang, Qin Yin, Yang Gu, Yindi Jiang

Journal: Journal of the American Chemical Society

PubMed ID: 40504680

Doi: 10.1021/jacs.5c02990

Products & Services: Gene Synthesis

Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

Authors: Ding Qiu, Shuishen Zhang, Chanyan Huang, Xinying Wang, Jianping Deng, Haiyang Sun, Bingbing Feng, Ying Tan, Kaile Ji, Shaoting Xu, Xiaoqi Ye, Chao Cheng, Shigeru Kakuta, Yoshiyuki Adachi, Yoichiro Iwakura, Shuai Wang, Shaowei Dong, Ce Tang

Journal: Immunity

PubMed ID: 40494347

Doi: 10.1016/j.immuni.2025.05.007

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Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

Products & Services: Proteins, Expression, Isolation and Analysis

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N Gurzov, Olov Andersson, Sumeet Pal Singh

Journal: Nature Communication

PubMed ID: 40480975

Doi: 10.1038/s41467-025-60334-y

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Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Yixi Dong, Runyu Zhao, Jia Man, Jianwei Jiao, Zhaoyin Wang, Jin Jiao

Journal: Theranostics

Doi: 10.7150/thno.111583

Products & Services: Proteins, Expression, Isolation and Analysis

Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation

Authors: Zixuan Mei, Kamuran Yilamu, Weiyu Ni, Panyang Shen, Nan Pan, Huasen Chen, Yingfeng Su, Lei Guo, Qunan Sun, Zhaomei Li, Dongdong Huang, Xiangqian Fang, Shunwu Fan, Haitao Zhang, Shuying Shen

Journal: nature COMMUNICATION

PubMed ID: 40425566

Doi: 10.1038/s41467-025-60037-4

Products & Services: Catalog Antibody Proteins, Expression, Isolation and Analysis

MechanismsofaureobasidinA inhibition and drug resistance in a fungal IPC synthase complex

Authors: Xinyue Wu , Xin Gong , Tian Xie

Journal: nature COMMUNICATION

PubMed ID: 40442105

Doi: doi.org/10.1038/s41467-025-60423-y

Products & Services: Proteins, Expression, Isolation and Analysis

DNA-Engineered Modular Nanovaccines Featuring Precise Topology for Enhanced Immunogenicity

Authors: Yanfei Qu, Dawei Wang, Yunlong Zhang, Fengyun Shen, Binghui Xia, Qin Xu, Qisheng Wang, Huating Kong, Ying Zhu, Lihua Wang, Itamar Willner, Xiurong Yang, Chunhai Fan, Lele Sun

Journal: ADVANCED MATERIALS

PubMed ID: 40371439

Doi: 10.1002/adma.202500577

Products & Services: Protein Reagents and Products

Deep Proteomic Profiling of the Intra-Golgi Trafficking Intermediates

Authors: Farhana Taher Sumya , Walter S Aragon-Ramirez , Vladimir V Lupashin

Journal: MOLECULAR BIOLOGY OF THE CELL

PubMed ID: 40397568

Doi: 10.1091/mbc.E24-12-0556

Products & Services: Gene Synthesis

LPS-enriched interaction drives spectrum conversion in antimicrobial peptides: Design and optimization of AA16 derivatives for targeting gram-negative bacteria

Authors: Wanyang Xiao, Ruize Sun, Jietao Lou, Yanyan Xu, Xiaokun Li, Kaiyun Xin, Weijie Lu, Chenhui Sun, Tianbao Chen, Yitian Gao, Di Wu

Journal: Eur J Med Chem

PubMed ID: 40048797

Doi: 10.1016/j.ejmech.2025.117462

Products & Services: Peptide Synthesis

Engineering galactose oxidase for biocatalytic synthesis of 2-(furan-2-yl)-2-oxoacetic acid, a critical precursor of cefuroxime

Authors: Tong Zhang, Hao Wei, Yunju Zhang, Tengteng Qi, Kehao Yuan, Bin Wang, Ziyan Zhang, Liangqing Chen, Qinyuan Ma, Xiuzhen Gao

Journal: Journal Pre-proof

Doi: 10.1016/j.gresc.2025.05.010

Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis

Authors: Zhike Chen, Jian Yang, Qiang Zhang, Weibiao Zeng, Yi Liu, Wenxuan Hu, Linfu Chen, Jingjing Shen, Yu Miao, Zhisheng Xiao, Zhiqiang Wu, He Wang, Hui Shen, Cheng Ding, Qian Chen, Jun Zhao, Yang Yang

Journal: Science Advances

PubMed ID: 40305619

Doi: 10.1126/sciadv.adv9571

Products & Services: Proteins, Expression, Isolation and Analysis

Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase-Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Authors: Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu

Journal: Adv Sci (Weinh)

PubMed ID: 40365750

Doi: 10.1002/advs.202505310

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Accurate Mapping of 5-Glyceryl-methylcytosine Using Nanopore Sequencing

Authors: Linting Wang, Baodan He, Zixin Wang, Liting Kang, Jianhuang Xue, Shuanghong Yan

Journal: Anal Chem

PubMed ID: 40314134

Doi: 10.1021/acs.analchem.5c00845

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De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses

Authors: Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chen

Journal: Cell

PubMed ID: 40436014

Doi: 10.1016/j.cell.2025.05.003

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Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning Mutagenesis Services

PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Journal: Signal Transduct Target Ther

PubMed ID: 40393983

Doi: 10.1038/s41392-025-02250-7

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Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence

Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang

Journal: ACS Catalysis

Doi: doi.org/10.1021/acscatal.5c01673

Products & Services: Gene Synthesis Codon Optimization

Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

Products & Services: Molecular Biology Tools

The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

Authors: Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Journal: Genes Dev

PubMed ID: 40169231

Doi: 10.1101/gad.352389.124

Products & Services: Mutagenesis Services Custom Vector Construction Proteins, Expression, Isolation and Analysis Custom Vector Construction Mutagenesis Services Protein Reagents and Products

BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner

Authors: Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou

Journal: Theranostics

Doi: 10.7150/thno.110122

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Teleost GSDMEc regulates GSDMEa-mediated pyroptos

Authors: Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li Sun

Journal: J Adv Res

PubMed ID: 40210150

Doi: doi.org/10.1016/j.jare.2025.04.007

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection

Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li

Journal: Sensors and Actuators: B. Chemical

Doi: doi.org/10.1016/j.snb.2025.137828

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Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition

Authors: Meihui Tao, Li Wang, Chaoyue Chen, Mengfan Tang, Yanping Wang, Jingyue Zhang, Xi Zhao, Qinyu Feng, Junfa Chen, Wei Yan, Rong Lin, Yu Fu

Journal: Journal of Advanced Research

PubMed ID: 40288675

Doi: 10.1016/j.jare.2025.04.030

Products & Services: Mammalian Expression Recombinant Proteins

An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element

Authors: Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong

Journal: Sci Adv

PubMed ID: 40249801

Doi: 10.1126/sciadv.adv9640

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Fused exosomal targeted therapy in periprosthetic osteolysis through regulation of bone metabolic homeostasis

Authors: Tianliang Ma, Qimeng Liu, Zheyu Zhang, Jiangyu Nan, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie

Journal: Bioactive Materials

PubMed ID: 40248188

Doi: doi.org/10.1016/j.bioactmat.2025.04.006

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphorylation dependent charge block regulate the relaxation of nuclear speckle networks

Authors: Mengjun Zhang, Zhuang Gu, Yingtian Sun, Yichen Dong, Junlin Chen, Li Shu, Suibin Ma, Jierui Guo, Yuhang Liang, Qingming Qu, Ning Fang, Chuan-Qi Zhong, Yifan Ge, Zhongwen Chen, Shaohui Huang, Xin Zhang, Bo Wang

Journal: Mol Cell

PubMed ID: 40233760

Doi: 10.1016/j.molcel.2025.03.016

Products & Services: Proteins, Expression, Isolation and Analysis

N-Terminal random curl-tandam α-helical peptide 7W: A potent antibacterial and anti-inflammatory dual-effect agent through tryptophan substitution

Authors: Jietao Lou, Xinyi Wu, Wenwen Ji, Jiaye Yu, Yanyan Xu, Wanyang Xiao, Weijie Lu, Kaiyun Xin, Tianbao Chen, Qidong Tang, Guang Liang, Yitian Gao, Di Wu

Journal: Eur J Med Chem

PubMed ID: 40319576

Doi: 10.1016/j.ejmech.2025.117686

Products & Services: Peptide Synthesis

Fullerol Initiates Stem Cell–Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling

Authors: Haoyang Liu, Yue Zhu, Weixu Chen, Renwang Sheng, Chuanquan Liu, Yuzhi Sun, Jia Liu, Mingyue Wang, Jun Lu, Jialin Chen, Wei Zhang

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.5c01731

Products & Services: Recombinant Proteins

Targeted Delivery of mRNA with Polymer−Lipid Nanoparticles for In Vivo Base Editing

Authors: Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li

Journal: ACS Nano

PubMed ID: 39962883

Doi: 10.1021/acsnano.4c14041

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Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian

Journal: Cell Rep

PubMed ID: 40272981

Doi: 10.1016/j.celrep.2025.115611

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Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy

Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang

Journal: Advanced Functional Materials

Doi: doi.org/10.1002/adfm.202501954

Products & Services: Recombinant Proteins

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu

Journal: Cell Discov

PubMed ID: 11962085

Doi: 10.1038/s41421-025-00779-z

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Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry

Authors: Yafeng Wu，Zixuan Chen，Fengxiang Chen，Juan Su，Jianyu Han，Songqin Liu

Journal: Anal Chem

PubMed ID: 40183921

Doi: 10.1021/acs.analchem.5c00365

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Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus

Authors: Haining Li , Luyuan Shao , Zhe Liu , Qi Liu , Ye Xiang

Journal: Nat Commun

PubMed ID: 40301360

Doi: 10.1038/s41467-025-59301-4

Products & Services: Proteins, Expression, Isolation and Analysis

Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy

Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang

Journal: ACS Nano

PubMed ID: 40190094

Doi: 10.1021/acsnano.4c17090.

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

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Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis

Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu

Journal: Cell Death Discov

PubMed ID: 40188090

Doi: 10.1038/s41420-025-02443-7.

Products & Services: Proteins, Expression, Isolation and Analysis

2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells

Authors: Hao Wang, Min Zhou, Yifeng Ruan, Yifei Shen, Ziqi Qin, Xingbo Wu, Huiling Ling, Wushuang Ye, Yongfu Wang, Xueqi Gan

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.163130

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The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization

Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel

Journal: Plant Direct

PubMed ID: 40212536

Doi: doi.org/10.1002/pld3.70054

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Astragalus Polysaccharides Ameliorate Diabetic Bladder Dysfunction via Normalization of Neuromuscular Conduction

Authors: Shaochan Liang, Siyuan Xu, Shenglian Ye, Lang Liang, Hongliang Li, Jiaye Liu, Yao Zhang, Feng Zou, Xiaodan Liang, Bo Tan, Hongying Cao

Journal: J Agric Food Chem

PubMed ID: 40032633

Doi: 10.1021/acs.jafc.4c11577

Products & Services: Proteins, Expression, Isolation and Analysis

The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during Pseudomonas syringae pv. tomato DC3000 infection

Authors: Yujie Dai, Xiaodan Li, Yeling He, Liya Zhu, Yan Bi, Fengming Song, Dayong Li

Journal: Horticulture research

PubMed ID: 40303438

Doi: 10.1093/hr/uhaf078

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Expediting Genome Synthesis of Corynebacterium glutamicum with An Artificial Chromosome Vector

Authors: Zhanhua Zhang, Peixiong Hong, Zebin Li, Baitao Li, Tai Chen, Yue Shen, Xiaofeng Yang, Yanrui Ye, Yun Wang, Zhanglin Lin

Journal: Trends Biotechnol

PubMed ID: 40155267

Doi: 10.1016/j.tibtech.2025.02.019

Products & Services: Proteins, Expression, Isolation and Analysis

The structure and function of the ghrelin receptor coding for drug actions

Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho

Journal: Nat Struct Mol Biol

PubMed ID: 39833471

Doi: 39833471

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Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator

Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian

Journal: Cell Res

PubMed ID: 40118988

Doi: doi.org/10.1038/s41422-025-01095-7

Products & Services: Antibody Modification and Purification Services Proteins, Expression, Isolation and Analysis

Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα

Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich

Journal: Int J Mol Sci

PubMed ID: 40243928

Doi: ijms26073178

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A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration

Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li

Journal: ADVANCED FUNCTIONAL MATERIALS

Doi: 10.1002/adfm.202500603

Products & Services: Proteins, Expression, Isolation and Analysis

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