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Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

Metabolic Hijacking by Engineered Probiotics Reprograms Tumor Metabolism and Immune Microenvironment for Self-Reinforcing Photodynamic Immunotherapy

Authors: Shurong Qin, Qi Wang, Zhuangwei Zhang, Junhui Gu, Guanzhong He, Fei Zeng, Ruiyue Chen, Bangshun He, Yuzhen Wang, Meng Wang, Yujun Song

Journal: Journal of the American Chemical Society

PubMed ID: 41059938

Doi: 10.1021/jacs.5c10242

Products & Services: Recombinant Proteins

Protein M fusion proteins and uses

Authors: Jay Dela Cruz , Moreno Valley , CA

Journal: U.S. Patent

Doi: US11401309B2

Products & Services: Gene Synthesis Plasmid DNA Preparation Catalog Antibody Codon Optimization

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Authors: Man Wang, Ziyu Zhang, Xiaohan Wang, Liyan Zhang, Xiangyan Chen, Nianci Li, Qiuhan Sun, Yicheng Lu, Zuhong He, Hongbo Yang, Fangzhi Tan, Jieyu Qi, Renjie Chai

Journal: Nature Communications

PubMed ID: 40968144

Doi: 10.1038/s41467-025-63613-w.

Products & Services: Proteins, Expression, Isolation and Analysis

Multifunctional NAC transcription factor SlJA2L integrates the ethylene pathway to orchestrate thermotolerance and fruit ripening in tomato

Authors: Yunfei Liang, Fang Ma, Shudi Huang, Chao Ma, Hongyan Shi, Fanyi Meng, Yinglu Chen, Han Dong, Rugang Chen, Xiangqiang Zhan

Journal: New Phytologist

PubMed ID: 40963426

Doi: 10.1111/nph.70571

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Multilevel regulation of c-di-GMP biosynthesis by cAMPsignalingincreasesShigellasonneifitnessand pathogenicity in response to bile salts

Authors: Mingfang Wang, Jia Zeng, Binbin Cui, Guangliang Wu, Xiayu Chen, Yikai Fu, Bing Gu, Yinyue Deng

Journal: Cell Rep

PubMed ID: 40966079

Doi: 10.1016/j.celrep.2025.116306

Products & Services: Proteins, Expression, Isolation and Analysis

OsEHD1 and OsEHD2, two EH domain proteins targeted by E3 ubiquitin ligase OsBBI1, negatively modulate rice immunity against blast and bacterial blight diseases

Authors: Yan Bi, Yuqing Yan, Hui Wang, Leeza Tariq, Jiamu Wang, Dayong Li, Yayun Yang, Fengming Song

Journal: Crop Journal

Doi: doi.org/10.1016/j.cj.2025.09.003

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Machine learning-based analysis of the impact of 5′ untranslated region on protein expression

Authors: Linfeng Wang, Sujia Liu, Jia-Xin Huang, Haifeng Zhu, Shuyu Li, Yannan Li, Sen Chen, Jianying Han, Yin Zhu, Jiahao Wu, Wentao Liao, Hongmei Zhang, Haiyan Zeng, Shaoting Li, Shuping Zhao, Bingwei Wang, Jiaqi Lin, Ji Zeng

Journal: Nucleic Acids Research

PubMed ID: 40923765

Doi: 10.1093/nar/gkaf861

Products & Services: Gene Synthesis

Peptide codes for organ-selective mRNA delivery

Authors: Tie Chang, Yifan Zheng, Mingrui Jiang, Siqi Jia, Jianbo Bai, Zhi Zheng, Shixin Li, Jia Guo, Yue Wang, Yiting Wang, Haixia Liu, Jianlin Liu, Liangyu Ni, Xingdi Cheng, Shuai Liu, Huijuan Zhang, Wei Pi, Feng Lin, Shiyi Liu, Weijian Wang, Guannan Wang, Leyun Wang, Lei Miao, Xueguang Lu, Ziqing Deng, Bing Bai, Zhao Qin, Huajian Gao, Yue Shao

Journal: Nature materials

PubMed ID: 40890497

Doi: 10.1038/s41563-025-02331-6

Products & Services: GenCrispr Cas9 Genome Editing

Amplifying antigen-induced cellular responses with proximity labelling

Authors: Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao, Shuo Han

Journal: Nature

PubMed ID: 40931066

Doi: 10.1038/s41586-025-09518-6. Online ahead of print.

Products & Services: Peptide Synthesis

OsSTK-mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defense in Rice

Authors: Jitao Hu, Linying Li, Yao Zhao, Xueying Zhang, Hua Wang, Junmin Wang, Peng Sun, Li Jiang, Jingqi Wang, Lili Chen, Zhongjing Zhou, Jiaoyu Wang, Keke Yi, Yuqing He, Gaojie Hong

Journal: Plant Biotechnology Journal

PubMed ID: 40927945

Doi: 10.1111/pbi.70358

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Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles

Authors: An Lao, Weiqi Li, Yiting Sun, Yuting Cao, Yu Zhuang, Jianyong Wu, Dejian Li, Kaili Lin, Jing Mao, Jiaqiang Liu

Journal: Trends in biotechnology

PubMed ID: 40925799

Doi: 10.1016/j.tibtech.2025.07.025

Products & Services: Proteins, Expression, Isolation and Analysis

A reproducible hybrid membrane for in situ analysis of cell secretions with a wide size range

Authors: Zixuan Chen, Yafeng Wu, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.110917

Products & Services: Recombinant Proteins

De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Authors: Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Tao Qian, Bang-Ce Ye, Bin-Cheng Yin

Journal: Nat Commun

PubMed ID: 41006213

Doi: 10.1038/s41467-025-63166-y

Products & Services: Gene Synthesis

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects Against In Vivo Infection via the Induction of Broad-Spectrum PRRSV Neutralization

Authors: Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A Hiscox, James P Stewart, Yani Sun, Qin Zhao

Journal: Advanced Science

PubMed ID: 40919718

Doi: 10.1002/advs.202508875

Products & Services: Molecular Biology Reagents

Planthopper protein Nlsp5 is essential for salivary sheath formation and acts as a HAMP inducing plant resistance to insects

Authors: Liangxuan Qi, Jing Li, Han Wang, Shuai Li, Lei Yang, Jichao Fang, Rui Ji

Journal: Plant Biotechnology Journal

PubMed ID: 40546084

Doi: DOI10.1111/pbi.70223

Products & Services: Polyclonal Antibody Services

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

Authors: Bin Liu, Yansi Xian, Tao Shen, Yu Ben, Wenshu Wu, Yong Shi, Xueying An, Rui Peng, Wentian Gao, Wang Gong, Xiang Chen, Baosheng Guo, Qing Jiang

Journal: Journal of extracellular vesicles

PubMed ID: 40919882

Doi: 10.1002/jev2.70162

Products & Services: Proteins, Expression, Isolation and Analysis

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

Journal: Nature Communications

PubMed ID: 40813592

Doi: doi.org/10.1038/s41467-025-63101-1

Products & Services: Peptide Synthesis

Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases

Authors: Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Journal: Biomolecules

PubMed ID: 40867598

Doi: 10.3390/biom15081153

Products & Services: Gene Synthesis

Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma

Authors: Shi-Man Zhang, Xiao-Kang Jin, Hong Chen, Yu-Zhang Wang, Jun-Long Liang, Jun Feng, Wei-Hai Chen, Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 40757917

Doi: 10.1002/adma.202508457

Products & Services: Catalog Peptides

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress

Authors: Hui Guan, Liqi Huang, Yu Liu, Enyi Zhu, Lefeng Chen, Weijie Li, Haiqi Wu, Xiaoying Zhang, Rencai Qin, Jingpeng Zheng, Yingqian Mo, Ming Zhong, Bihua Xu, Xiaoyan Dai, Qi Wei, Yunwei Chen, Qingwen Wang, Zhihua Zheng, Kongyang Ma, Chun Tang

Journal: Journal of Inflammation Research

PubMed ID: 106070

Products & Services: Endotoxin Detection & Removal System

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

Authors: Zeguang Wu, Jinhong Shi, Qiezhong Lamao, Yuanyuan Qiu, Jinxin Yang, Yang Liu, Feifei Liang, Xue Sun, Wei Tang, Changya Chen, Qingming Yang, Chunmeng Wang, Zhifang Li, Haixia Zhang, Zhonghan Yang, Yunyi Zhang, Yuting Yi, Xufen Zheng, Yu Sun, Kuiying Ma, Lingling Yu, Huihui Yang, Zhaoxuan Wang, Wenjuan Zheng, Ling Yang, Zhixuan Zhang, Yongjian Zhang, Zhiqiang Wu, Yao Wang, Catherine C L Wong, Ming Jin, Pengfei Yuan, Weidong Han, Wensheng Wei

Journal: Cell

PubMed ID: 40845838

Doi: doi.org/10.1016/j.cell.2025.07.046

Products & Services: Synthetic sgRNA and crRNA Service

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection

Authors: Yannan Yin, Jinkai Zang, Huichun Shi, Zhuang Wang, Linlin Kuang, Shuxia Wang, Haikun Wang, Ning Li, Xiaozhen Liang, Zhong Huang

Journal: Vaccines

PubMed ID: 40872916

Products & Services: Gene Synthesis

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales

Authors: Chao Sun, Hongchao Li, Yijing Liu, Jinxing Liu, Ronghong Liang, Caixia Gao

Journal: CELL

PubMed ID: 40763736

Doi: 10.1016/j.cell.2025.07.011

Products & Services: Gene Synthesis

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-DietInduced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Authors: Shuai Wang, Shuting Liu, Ting He, Huanming Shen, Chunli Mo, Yu Zhu, Wenlo, Weihua Li, Jian Zhang

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 40810347

Doi: doi.org/10.1021/acs.jafc.5c02577

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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

Journal: Nature Communications

PubMed ID: 40790299

Doi: doi.org/10.1038/s41467-025-62870-z

Products & Services: Gene Synthesis

Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy

Authors: Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng

Journal: Advanced Science

PubMed ID: 40874418

Doi: 10.1002/advs.202511144

Products & Services: Proteins, Expression, Isolation and Analysis

Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration

Authors: An Lao, Yiting Sun, Weiqi Li, Yu Zhuang, Ziyang Liu, Chenci Xu, Xiangbing Wu, Linhu Ge, Kaili Lin, Jianyong Wu, Jing Mao, Jiaqiang Liu

Journal: Biomaterials

PubMed ID: 40916241

Doi: 10.1016/j.biomaterials.2025.123656

Products & Services: Proteins, Expression, Isolation and Analysis

Aligned Electrospun Fibers Inducing Cell and Nuclear Morphology Remodeling via Ras-Associated Protein 1/Yes-Associated Protein Signaling Enhances Bone Regeneration

Authors: Shengjie Jiang, Jialiang Zhou, Cancan Zhao, Liyun Wang, Zeyu Fu, Mazaher Gholipourmalekabadi, Xudong Wang, Changyong Yuan, Kaili Lin

Journal: Advanced Fiber Materials

Doi: 10.1007/s42765-025-00596-9

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In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Authors: Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruihan Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Journal: Nature Chemical Biology

PubMed ID: 40775047

Doi: 10.1038/s41589-025-01993-2

Products & Services: Proteins, Expression, Isolation and Analysis

FlaB-expressing bacterial uter membrane vesicles vaccine mediating anti-tumor immune response via promoting DCs activation and lymph nodes-homing

Authors: Kaiwei Wang, Chang Xu, Minming Chen, Yifan Yan, Nanhui Liu, Changhao Zhao, Bo Liu, Yanbin Liu, Jianjiang Chen, Xiaoliang Ding, Yicong Bian, Lin Song, Xuyu Bian, Yumin Wu, Liyan Miao, Zhuang Liu

Journal: Nano Research

PubMed ID: 40817136

Doi: 10.26599/NR.2025.94907612

Products & Services: Proteins, Expression, Isolation and Analysis

Lumpy skin disease virus LSDV001 protein positively regulates inflammatory response by promoting assembly of the TAK1- TAB2/3 complex

Authors: Yu-Lin Yang, Huai-Jie Jia, Meng-Yao Sun, Ai-Min Guo, Tian Xia, Hong-Bing Shu, Li-Bo Cao

Journal: MBio

PubMed ID: 40852992

Doi: 10.1128/mbio.01677-25

Products & Services: Polyclonal Antibody Services

Bioorthogonal Non-Canonical Amino Acid Tagging (BONCAT) to detect newly synthesized proteins in cells and their secretome

Authors: Elizabeth P. Anim, Justin Mezzanotte, Siwei Chu, Ursula Stochaj

Journal: PLoS One

PubMed ID: 40811457

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains

Authors: Zebin Tong, Xiangwei Wu, Hongyi Cai, Shidian Wu, Tianyi Zhang, Zhiheng Deng, Ziyu Xu, Rujing Yuan, Huasong Ai, Lei Liu, Man Pan

Journal: Nature Chemical Biology

PubMed ID: 40817136

Doi: 10.1038/s41589-025-01985-2

Products & Services: Gene Synthesis

Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice

Authors: Shunyi Lu, Jie Cao, Zhuorun Song, Fei Gong, Peng Yang, Jun Ge, Yunfei He, Zhihui Han, Guanghui Hou, Zimin Zhang, Yuqi Yang, Yun Teng, Zengli Zhang, Jun Zou, Liang Cheng, Huilin Yang

Journal: Nature Communications

PubMed ID: 40885754

Doi: doi.org/10.1038/s41467-025-63456-5

Products & Services: Proteins, Expression, Isolation and Analysis

AMPGen: an evolutionary information-reserved and diffusion-driven generative model for de novo design of antimicrobial peptides

Authors: Shuwen Jin, Zihan Zeng, Xiyan Xiong, Baicheng Huang, Li Tang, Hongsheng Wang, Xiao Ma, Xiaochun Tang, Guoqing Shao, Xingxu Huang, Feng Lin

Journal: Communications Biology

PubMed ID: 40447738

Doi: 10.1038/s42003-025-08282-7

Products & Services: Peptide Synthesis

A Molecular Mechanism for the Reduction of the Cu Site in Lytic Polysaccharide Monooxygenases by Phenol Reductants

Authors: Langxing Liao, Jian Kuang, Peng Wu, Xianhang Sang, Heng Yin, Changlin Ti, Kingwang Zhang, Wei Peng, Lu Yu, Binju Wang

Journal: JACS Au

Doi: 10.1021/jacsau.5c00562

Products & Services: Gene Synthesis

Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode

Authors: Xi Lin, Xiaohu Wei, Ning Pu, Ling Wang, Zhibin Zhang, Cuixia Li, Yang Yue, Junlin Liu, Qiwen Tan, Qianqian Sun, Fei Xu

Journal: Cell Research

PubMed ID: 40813798

Doi: 10.1038/s41422-025-01165-w

Products & Services: Proteins, Expression, Isolation and Analysis

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Journal: Journal of the American Chemical Society

PubMed ID: 40774922

Doi: doi.org/10.1021/jacs.5c08814

Products & Services: Gene Synthesis

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens

Journal: NATURE CELL BIOLOGY

PubMed ID: 40715440

Doi: 10.1038/s41556-025-01712-y

Products & Services: Gene Synthesis

Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants

Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji

Journal: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

PubMed ID: 40543628

Doi: 10.1016/j.ibmb.2025.104351

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Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou

Journal: Communications Biology

PubMed ID: 40783594

Doi: 10.1038/s42003-025-08607-6.

Products & Services: Proteins, Expression, Isolation and Analysis

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin.

Authors: Jing-Xiao Wang, Xiao-Yu Xu, Hong-Ke Dong, Yi-Ming Wang, Min Dai, Bing Zhou, Yue-Hua Li, Guo-Qing Zhu, Xiao-Qing Xiong

Journal: Journal of Extracellular Vesicles

PubMed ID: 40767027

Doi: 10.1002/jev2.70146.

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Lung metastasis and recurrence is mitigated by CARmacrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Authors: Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang