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Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Authors: Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruihan Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Journal: Nature Chemical Biology

PubMed ID: 40775047

Doi: 10.1038/s41589-025-01993-2

Products & Services: Proteins, Expression, Isolation and Analysis

Lung metastasis and recurrence is mitigated by CARmacrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Authors: Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang

Journal: Nature Communications

PubMed ID: 40759657

Doi: 10.1038/s41467-025-62506-2

Products & Services: Custom DNA/RNA Oligos

Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii

Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang

Journal: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PubMed ID: 40616507

Doi: doi.org/10.1021/acs.jafc.5c03402

Products & Services: Gene Synthesis

An integrated electrochemical nanodevice for single-cell MiRNA-155 detection and drug evaluation

Authors: Zhuo Li , Zhaohan Wang , Jun Chen , Yafeng Wu

Journal: BIOSENSORS & BIOELECTRONICS

PubMed ID: 40695112

Doi: 10.1016/j.bios.2025.117804

Products & Services: PCR Cloning and Subcloning

Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles

Authors: Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin

Journal: Interdisciplinary Materials

Doi: doi.org/10.1002/idm2.70000

Products & Services: Proteins, Expression, Isolation and Analysis

A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao

Journal: Advanced Science

PubMed ID: 40685690

Doi: 10.1002/advs.202509419

Products & Services: Proteins, Expression, Isolation and Analysis

ZEB2 is a master switch controlling the tumor-associated macrophage program

Authors: Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher-Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan, Kiara Freitag, Ido Yofe, Vladimir Yutkin, Pierre Boyeau, Can Ergen, Justin Hong, Kfir Mazuz, Yuxiao Liu, Kangming Chen, Rony Dahan, Marcin Kortylewski, Nir Yosef, Assaf Weiner, Ido Amit

Journal: Cancer Cell

PubMed ID: 40215981

Doi: 10.1016/j.ccell.2025.03.021

Products & Services: Synthetic sgRNA and crRNA Service

Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma

Authors: Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue

Journal: ACS Nano

PubMed ID: 40698543

Doi: 10.1021/acsnano.5c08928

Products & Services: Catalog Antibody

BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

Authors: Chen Guo, Zhilin Long, Peng Lin, Yinan Shen, Yiye Zhong, Jingjing Qian, Jichuan Yu, Weixi Zhao, Fuyi Liu, Yiling Ma, Jian Zheng, Jiayao Yang, Shuai Zhao, Xiaojuan Ran, Zhen Xia, Congying Wu, Yujia Cai, Chen Wang, Qi Xie

Journal: Cell Reports Medicine

PubMed ID: 40744020

Doi: 10.1016/j.xcrm.2025.102258

Products & Services: GenCrispr Cas9 Genome Editing

Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Proteins, Expression, Isolation and Analysis

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: MICROCHEMICAL JOURNAL

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization

Authors: Di Wang, Linzhu Zhang, Jihu Nie, Nailin Yang, Shumin Sun, Chunjie Wang, Zifan Pei, Fei Gong, Xingwei Sun, Yong Jin, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 40644662

Doi: 10.1021/jacs.5c06039

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

Journal: nature COMMUNICATION

PubMed ID: 40681508

Doi: 10.1038/s41467-025-62023-2

Products & Services: Protein A Resin

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis

Authors: Weixia Liu , Guodi Wu , Jing Wang , Shanshan Wu , Zhi Chen

Journal: Molecular Medicine Reports

PubMed ID: 40376993

Doi: 10.3892/mmr.2025.13567

Products & Services: Proteins, Expression, Isolation and Analysis

An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment

Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen

Journal: Acta Biomaterialia

PubMed ID: 40409996

Doi: 10.1016/j.actbio.2025.05.040

Products & Services: Recombinant Proteins

AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

Authors: Keyu Kong, Li Liu, Renfang Zhang, Yongyun Chang, Yueming Shao, Chen Zhao, Hua Qiao, Minghao Jin, Xuzhuo Chen, Wentao Shi, Xinru Wu, Wenxuan Fan, Yuehao Hu, Kewei Rong, Pu Zhang, Baixing Li, Jingwei Zhang, Peixiang Ma, Xiaoling Zhang, Huiwu Li, Zanjing Zhai

Journal: Bone Research

PubMed ID: 40461512

Doi: 10.1038/s41413-025-00431-2

Products & Services: Recombinant Proteins

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling

PubMed ID: 40514668

Doi: 10.1186/s12964-025-02289-7

Products & Services: Proteins, Expression, Isolation and Analysis

Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong

Journal: Cellular & Molecular Immunology

PubMed ID: 40500403

Doi: 10.1038/s41423-025-01305-7

Products & Services: Proteins, Expression, Isolation and Analysis

Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus

Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song

Journal: International Journal of Biological Macromolecules

PubMed ID: 40543771

Doi: doi.org/10.1016/j.ijbiomac.2025.145363

Products & Services: Catalog Peptides

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

Products & Services: Peptide Modifications

Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

Authors: Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos-Rodriguez, Katherine H. Griffin, Gabriella C. Bond, J. Kent Leach

Journal: ADVANCED FUNCTIONAL MATERIALS

Doi: 10.1002/adfm.202311017

Products & Services: Peptide Synthesis

Antimicrobial and Potent Anti- Biofilm Properties of Rationally Designed α- Helix Antimicrobial Peptides

Authors: Motasim Ismael, Khayeli Juliah, Madivoli Edwin

Journal: Journal of Peptide Science

PubMed ID: 40326595

Doi: 10.1002/psc.70027

Products & Services: Peptide Synthesis

Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

Authors: Ding Qiu, Shuishen Zhang, Chanyan Huang, Xinying Wang, Jianping Deng, Haiyang Sun, Bingbing Feng, Ying Tan, Kaile Ji, Shaoting Xu, Xiaoqi Ye, Chao Cheng, Shigeru Kakuta, Yoshiyuki Adachi, Yoichiro Iwakura, Shuai Wang, Shaowei Dong, Ce Tang

Journal: Immunity

PubMed ID: 40494347

Doi: 10.1016/j.immuni.2025.05.007

Products & Services: Catalog Antibody

Collective Biosynthesis of Plant Spirooxindole Alkaloids through Enzyme Discovery and Engineering

Authors: Danni Chu, Hongkui Wang, Zhiwen Nie, Kang-Li Li, Jiaqing Cao, Meijing Yang, Qin Yin, Yang Gu, Yindi Jiang

Journal: Journal of the American Chemical Society

PubMed ID: 40504680

Doi: 10.1021/jacs.5c02990

Products & Services: Gene Synthesis

Control of seed-to-seedling transition by an upstream open reading frame in ABSCISIC ACID DEFICIENT2

Authors: Zhen Wang , Xiaofan Zhang ， Can Zhou , Xiaofeng Cao

Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PubMed ID: 40478869

Doi: 10.1073/pnas.2502155122

Products & Services: Gene Synthesis

Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15

Authors: Manashi Sonowal, Gihan Ketawala, Nirupa Nagaratnam, Dhenugen Logeswaran, Shibom Basu, Daniele de Sanctis, Julien Orlans, Samuel L Rose, Rebecca J Jernigan, Hao Hu, Jose Domingo Meza Aguilar, Madurangi E Ranaweera, Michele A Zacks, Julian J-L Chen, Debra T Hansen, Lynn G Schrag, Raimund Fromme, Sabine Botha, Petra Fromme

Journal: PROTEIN SCIENCE

PubMed ID: 40411374

Doi: 10.1002/pro.70115

Products & Services: Plasmids for SARS-CoV-2 Detection and Research Custom DNA/RNA Oligos

Sodium butyrate attenuates lipid metabolism disorder via improving mitochondrial function and activating autophagy in LMH cells

Authors: Sasa Miao, Mengru Xu, Fang Liu, Xinyang Dong, Xiaoting Zou, Tao Zeng, Lizhi Lu

Journal: POULTRY SCIENCE

Doi: doi.org/10.1016/j.psj.2025.105476

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePt Dual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis

Authors: Qianglan Lu, Chengwei Ye, Wei Mao, Fei Zeng, Zhiyong Liu, Ruiyue Chen, Xiao Cheng, Yanfeng Gao, Meng Wang, Mei Liu, Shaochun Tang, Yujun Song

Journal: ACS Nano .

PubMed ID: 40532220

Doi: 10.1021/acsnano.5c04686

Products & Services: CRISPR Libraries

NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence

Authors: Zheng Dai, Feng Liu, Miaodeng Liu, Yuqi Song, Hongyan Zhang, Cheng Zhou, Wenyu Liu, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang

Journal: Bioactive Materials

Doi: https://doi.org/10.1016/j.bioactmat.2025.06.037

Products & Services: Catalog Peptides

Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

Products & Services: Gene Synthesis Codon Optimization

Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Authors: Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu & Haipeng Gong

Journal: Nature Machine Intelligence

Doi: doi.org/10.1038/s42256-025-01059-x

Products & Services: Gene Synthesis

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

Authors: Shruthi Krishnaswamy, Shirin Akbar, Daniel S D Larsson, Yang Chen, Maria Selmer

Journal: Nature Communications

PubMed ID: 40571681

Doi: 10.1101/2024.12.14.628468

Products & Services: Custom DNA/RNA Oligos

Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

Products & Services: Proteins, Expression, Isolation and Analysis

RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

Products & Services: Catalog Antibody

Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

Products & Services: T7 RNA Polymerase

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

Products & Services: Proteins, Expression, Isolation and Analysis Anti-DYKDDDDK G1 Affinity Resin

Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

Products & Services: Proteins, Expression, Isolation and Analysis

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N Gurzov, Olov Andersson, Sumeet Pal Singh

Journal: Nature Communication

PubMed ID: 40480975

Doi: 10.1038/s41467-025-60334-y

Products & Services: Gene Synthesis

Histidine-Specific Modification of Chitin-Binding protein21 via Visible Light-Mediated C–H Functionalization and Protein Ligation

Authors: Xinliang Liu, Ping Wang and Farong Ye

Journal: CCS Chemistry

Doi: 10.31635/ccschem.024.202404864

Products & Services: Gene Synthesis Plasmid DNA Preparation

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Authors: Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel, Christopher P Earl, Samantha Fisher, Rhian S Holvey, Scott M Jackson, Emyr Lloyd-Evans, Carmine M Morgillo, Paul N Mortenson, Marc O'Reilly, Caroline J Richardson, Patrick Schöpf, Daniel M Tams, Helen Waller-Evans, Simon E Ward, Stuart Whibley, Pamela A Williams, Christopher N Johnson

Journal: Structure

PubMed ID: 40532704

Doi: 10.1016/j.str.2025.05.014

Products & Services: Codon Optimization

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

Authors: Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun & Yun-Jia Ning

Journal: Nature Communication

Doi: 10.1038/s41467-025-61431-8

Products & Services: Peptide Synthesis

Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Yixi Dong, Runyu Zhao, Jia Man, Jianwei Jiao, Zhaoyin Wang, Jin Jiao

Journal: Theranostics

Doi: 10.7150/thno.111583

Products & Services: Proteins, Expression, Isolation and Analysis

Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation

Authors: Zixuan Mei, Kamuran Yilamu, Weiyu Ni, Panyang Shen, Nan Pan, Huasen Chen, Yingfeng Su, Lei Guo, Qunan Sun, Zhaomei Li, Dongdong Huang, Xiangqian Fang, Shunwu Fan, Haitao Zhang, Shuying Shen

Journal: nature COMMUNICATION

PubMed ID: 40425566

Doi: 10.1038/s41467-025-60037-4

Products & Services: Catalog Antibody Proteins, Expression, Isolation and Analysis

MechanismsofaureobasidinA inhibition and drug resistance in a fungal IPC synthase complex

Authors: Xinyue Wu , Xin Gong , Tian Xie

Journal: nature COMMUNICATION

PubMed ID: 40442105

Doi: doi.org/10.1038/s41467-025-60423-y

Products & Services: Proteins, Expression, Isolation and Analysis

DNA-Engineered Modular Nanovaccines Featuring Precise Topology for Enhanced Immunogenicity

Authors: Yanfei Qu, Dawei Wang, Yunlong Zhang, Fengyun Shen, Binghui Xia, Qin Xu, Qisheng Wang, Huating Kong, Ying Zhu, Lihua Wang, Itamar Willner, Xiurong Yang, Chunhai Fan, Lele Sun

Journal: ADVANCED MATERIALS

PubMed ID: 40371439

Doi: 10.1002/adma.202500577

Products & Services: Protein Reagents and Products

Deep Proteomic Profiling of the Intra-Golgi Trafficking Intermediates

Authors: Farhana Taher Sumya , Walter S Aragon-Ramirez , Vladimir V Lupashin

Journal: MOLECULAR BIOLOGY OF THE CELL

PubMed ID: 40397568

Doi: 10.1091/mbc.E24-12-0556

Products & Services: Gene Synthesis

Cnidaria XIAP activates caspase-mediated cell death

Authors: Yuan Chen, Meng Wu, Zihao Yuan, Qingyue Wang, Hang Xu, Li Sun