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Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010

Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu

Journal: Int J Mol Sci

PubMed ID: 38791440

Doi: 10.3390/ijms25105402

Products & Services: Gene Synthesis

Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman

Journal: Nat Commun

PubMed ID: 38816420

Doi: 10.1038/s41467-024-49000-x

Products & Services: Molecular Biology Reagents

Tardigrade secretory proteins protect biological structures from desiccation

Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver

Journal: Commun Biol

PubMed ID: 38796644

Doi: 10.1038/s42003-024-06336-w

Products & Services: Proteins, Expression, Isolation and Analysis

Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat

Authors: Yayu Chen, Gen Wei, Lieliang Zhang, Xiaojin Feng, Enjun Lei

Journal: Exp Neurol

PubMed ID: 38823674

Doi: 10.1016/j.expneurol.2024.114842

Products & Services: Gene Synthesis

Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses

Authors: Emily Bettini, Aleksey Chudnovskiy, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Diana Castaño, Joy Chiu, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Zoltan Lipinszki, Ivan Maillard, Ying K Tam, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: biorxiv

PubMed ID: 38798523

Doi: 10.1101/2024.05.17.594726

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Single dual-specific anti-PD-L1/TGF-β antibody synergizes with chemotherapy as neoadjuvant treatment for pancreatic ductal adenocarcinoma: a preclinical experimental study

Authors: Haoxiang Zhang, Jiaoshun Chen, Jianwei Bai, Jing Zhang, Shaoyi Huang, Liang Zeng, Pengfei Zhou, Qiang Shen, Tao Yin

Journal: Int J Surg

PubMed ID: 38489548

Doi: 10.1097/JS9.0000000000001226

Products & Services: Proteins, Expression, Isolation and Analysis

HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation

Authors: Jing Ye, Xiyu Huang, Manman Yuan, Jinglin Wang, Ru Jia, Tianyi Wang, Yang Tan, Shun Zhu, Qiang Xu, Xingxin Wu

Journal: J Mol Cell Biol

PubMed ID: 38692847

Doi: 10.1093/jmcb/mjae018

Products & Services: Molecular Biology Reagents

Establishment of an ELISA Based on a Recombinant Antigenic Protein Containing Multiple Prominent Epitopes for Detection of African Swine Fever Virus Antibodies

Authors: Dossêh Jean Apôtre Afayibo, Zhonghui Zhang, Hualin Sun, Jingsheng Fu, Yaru Zhao, Tharheer Oluwashola Amuda, Mengli Wu, Junzheng Du, Guiquan Guan, Qingli Niu, Jifei Yang, Hong Yin

Journal: Microorganisms

PubMed ID: 38792774

Doi: 10.3390/microorganisms12050943

Products & Services: Catalog Antibody

A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-Ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado

Journal: Mol Brain

PubMed ID: 38790036

Doi: 10.1186/s13041-024-01104-7

Products & Services: Molecular Biology Reagents

Ser/Leu-swapped cell-free translation system constructed with natural/in vitro transcribed-hybrid tRNA set

Authors: Tomoshige Fujino, Ryogo Sonoda, Taito Higashinagata, Emi Mishiro-Sato, Keiko Kano, Hiroshi Murakami

Journal: Nat Commun

PubMed ID: 38755134

Doi: 10.1038/s41467-024-48056-z

Products & Services: Peptide Synthesis

Oriented immobilization of antibodies through peptide ligands for ultrasensitive detection of gastrin 17 in human serum via lateral flow immunoassay

Authors: Xintong Li , Jiale Cui , Jin Li , Yulian Wang , Guoqing Shi

Journal: Microchemical Journal

Doi: j.microc.2024.110819

Products & Services: Peptide Synthesis

Semi-rational design for enhancing thermostability of Culex pipiens acetylcholinesterase and sensitivity analysis of acephate

Authors: Shuoqi Jiang, Zhuangwei Zhang, Qiuya Gu, Xiaobin Yu

Journal: Sci Total Environ

PubMed ID: 38759926

Doi: 10.1016/j.scitotenv.2024.173282

Products & Services: Proteins, Expression, Isolation and Analysis

Saccharomyces cerevisiae oral immunization in mice using multi-antigen of the African swine fever virus elicits a robust immune response

Authors: Shuo Gao, Wenfeng Zuo, Chao Kang, Zhong Zou, Kaiqi Zhang, Jun Qiu, Xiaomin Shang, Jingjing Li, Yuanfeng Zhang, Qi Zuo, Ya Zhao, Meilin Jin

Journal: Front Immunol

PubMed ID: 38742108

Doi: 10.3389/fimmu.2024.1373656

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One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

Authors: Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani

Journal: Nat Commun

PubMed ID: 38615009

Doi: 10.1038/s41467-024-47466-3

Products & Services: Molecular Biology Reagents

Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase

Authors: Tao Zhang, Feiyu Zhao, Jinze Li, Xiaodi Sun, Xiyun Zhang, Hejun Wang, Peng Fan, Liangxue Lai, Zhanjun Li, Tingting Sui

Journal: Nucleic Acids Res

PubMed ID: 38366553

Doi: 10.1093/nar/gkae110

Products & Services: Molecular Biology Reagents

The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype

Authors: Anja Schollmeier, Michael Basic, Mirco Glitscher, Eberhard Hildt

Journal: J Virol

PubMed ID: 38629837

Doi: 10.1128/jvi.00424-24

Products & Services: Molecular Biology Reagents

Efficacy of genotype-matched vaccine against re-emerging genotype V Japanese encephalitis virus

Authors: Jae-Deog Kim, Ah-Ra Lee, Dah-Hyun Moon, Young-Uk Chung, Su-Yeon Hong, Hyo Je Cho, Tae Hyun Kang, Yo Han Jang, Myung Hyun Sohn, Baik-Lin Seong, Sang-Uk Seo

Journal: Emerg Microbes Infect

PubMed ID: 38618740

Doi: 10.1080/22221751.2024.2343910

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient activity screening of new glucuronoyl esterases using a pNP-based assay

Authors: Michael S Madsen, Pedro A Martins, Jane W Agger

Journal: Enzyme Microb Technol

PubMed ID: 38581869

Doi: 10.1016/j.enzmictec.2024.110444

Products & Services: Molecular Biology Reagents

Food-Grade Expression of Two Laccases in and Study on Their Enzymatic Degradation Characteristics for Mycotoxins

Authors: Zhen Sun, Yingxin You, Huidong Xu, Yang You, Wenjing He, Zhouping Wang, Aitao Li, Yu Xia

Journal: J Agric Food Chem

PubMed ID: 38600054

Doi: 10.1021/acs.jafc.4c00521

Products & Services: Gene Synthesis

Remotely controlled drug release in deep brain regions of non-human primates

Authors: Matthew G Wilson, Taylor D Webb, Henrik Odéen, Jan Kubanek

Journal: J Control Release

PubMed ID: 38604386

Doi: 10.1016/j.jconrel.2024.04.013

Products & Services: Proteins, Expression, Isolation and Analysis

An Elastin-Derived Composite Matrix for Enhanced Vascularized and Innervated Bone Tissue Reconstruction: From Material Development to Preclinical Evaluation

Authors: Nadia Mahmoudi, Micaela Roque, Bruno Paiva Dos Santos, Hugo Oliveira, Robin Siadous, Sylvie Rey, Elisabeth Garanger, Sébastien Lecommandoux, Sylvain Catros, Bertrand Garbay, Joëlle Amédée Vilamitjana

Journal: Adv Healthc Mater

PubMed ID: 38651610

Doi: 10.1002/adhm.202303765

Products & Services: Catalog Peptides

Broad-spectrum Delta-BA2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex

Authors: Pei Du, Lei Huang, Yi Fang, Fanfan Zhao, Qianyun Li, Xuehui Ma, Ruiqi Li, Qian Chen, Haifa Shen, Qihui Wang, Hangwen Li, George Fu Gao

Journal: PLoS Pathog

PubMed ID: 38557908

Doi: 10.1371/journal.ppat.1012116

Products & Services: Molecular Biology Reagents

Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of

Authors: Mary Nantongo, David C Nguyen, Christopher R Bethel, Magdalena A Taracila, Qing Li, Khalid M Dousa, Eunjeong Shin, Sebastian G Kurz, Liem Nguyen, Barry N Kreiswirth, W Henry Boom, Mark S Plummer, Robert A Bonomo

Journal: ACS Infect Dis

PubMed ID: 38619138

Doi: 10.1021/acsinfecdis.4c00119

Products & Services: Molecular Biology Reagents

Mechanistic insights into the alternative ribosome recycling by HflXr

Authors: Savannah M Seely, Ritwika S Basu, Matthieu G Gagnon

Journal: Nucleic Acids Res

PubMed ID: 38407413

Doi: 10.1093/nar/gkae128

Products & Services: Gene Synthesis

Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins

Authors: Shashank Khare, Miryam I Villalba, Juan C Canul-Tec, Arantza Balsebre Cajiao, Anand Kumar, Marija Backovic, Felix A Rey, Els Pardon, Jan Steyaert, Camilo Perez, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 38671230

Doi: 10.1038/s41594-024-01295-6

Products & Services: Catalog Peptides

CDK5-mediated rearrangement of vimentin during Duck Tembusu virus infection inhibits viral replication

Authors: Guangbin Bao, Shinuo Fan, Chunyan Hu, Chen Li, Fei Ma, Guijun Wang, Hongjie Fan, Qing Wang

Journal: Vet Microbiol

PubMed ID: 38574695

Doi: 10.1016/j.vetmic.2024.110071

Products & Services: Proteins, Expression, Isolation and Analysis

The Trimeric Autotransporter Adhesin SadA from spp as a Novel Bacterial Surface Display System

Authors: Shuli Sang, Wenge Song, Lu Lu, Qikun Ou, Yiyan Guan, Haoxia Tao, Yanchun Wang, Chunjie Liu

Journal: Vaccines (Basel)

PubMed ID: 38675781

Doi: 10.3390/vaccines12040399

Products & Services: Proteins, Expression, Isolation and Analysis

Plasmodium RNA triphosphatase validation as antimalarial target

Authors: Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G Gomez-Lorenzo

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 38810336

Doi: 10.1016/j.ijpddr.2024.100537

Products & Services: Molecular Biology Reagents

Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction

Authors: Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Wararat Chiangjong, Artitaya Rongjumnong, Atthapan Morchang, Somchai Chutipongtanate, Sutatip Pongcharoen

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38663552

Doi: 10.1016/j.bbamcr.2024.119736

Products & Services: Custom Vector Construction

Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to infected mosquito bites

Authors: Sarah Lapidus, Morgan M Goheen, Mouhamad Sy, Awa B Deme, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Kelly A Hagadorn, Seynabou Diouf Sene, Mariama Nicole Pouye, Laty Gaye Thiam, Aboubacar Ba, Noemi Guerra, Alassane Mbengue, Hamidah Raduwan, Inés Vigan-Womas, Sunil Parikh, Albert I Ko, Daouda Ndiaye, Erol Fikrig, Yu-Min Chuang, Amy K Bei

Journal: medrxiv

PubMed ID: 38712295

Doi: 10.1101/2024.04.20.24305430

Products & Services: Proteins, Expression, Isolation and Analysis

Specificity of DNA ADP-Ribosylation Reversal by NADARs

Authors: Bara Cihlova, Yang Lu, Andreja Mikoč, Marion Schuller, Ivan Ahel

Journal: Toxins (Basel)

PubMed ID: 38787060

Doi: 10.3390/toxins16050208

Products & Services: Molecular Biology Reagents

Development of an isotope dilution mass spectrometry assay for the quantification of insulin based on signature peptide analysis

Authors: Shangying Ma, Rimei He, Tingting Jiang, Zhishang Hu, Zihong Ye, Wei Mi

Journal: Anal Bioanal Chem

PubMed ID: 38556594

Doi: 10.1007/s00216-024-05258-0

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Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro

Authors: Qianjie Yang, Yutong Xia, Kuangqi Chen, Yinhao Wang, Dongjie Song, Jiru Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 38663336

Doi: 10.1016/j.jphotobiol.2024.112908

Products & Services: Molecular Biology Reagents

iJAZ-based approach to engineer lepidopteran pest resistance in multiple crop species

Authors: Huijuan Mo, Huimin Chang, Ge Zhao, Guanjing Hu, Xiumei Luo, Xue Jia, Zhenlu Xu, Guangming Ren, Li Feng, Jonathan F Wendel, Xiaoya Chen, Maozhi Ren, Fuguang Li

Journal: Nat Plants

PubMed ID: 38684916

Doi: 10.1038/s41477-024-01682-3

Products & Services: Gene Synthesis

Specifically targeting antimicrobial peptides for inhibition of Candidatus Liberibacter asiaticus

Authors: Samavath Mallawarachchi, Haoqi Wang, Nirmitee Mulgaonkar, Sonia Irigoyen, Carmen Padilla, Kranthi Mandadi, James Borneman, Sandun Fernando

Journal: J Appl Microbiol

PubMed ID: 38509024

Doi: 10.1093/jambio/lxae061

Products & Services: Proteins, Expression, Isolation and Analysis

The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia

Authors: Jorge Baquero, Xiao-Han Tang, Annalisa Ferrotta, Tuo Zhang, Krysta M DiKun, Lorraine J Gudas

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38599260

Doi: 10.1016/j.bbadis.2024.167161

Products & Services: ORF cDNA Clones/MolecularCloud

LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation

Authors: Meng Li, Yali Hou, Yuzheng Zhou, Zhenni Yang, Hongyu Zhao, Tao Jian, Qianxi Yu, Fuxing Zeng, Xiaotian Liu, Zheng Zhang, Yan G Zhao

Journal: J Cell Biol

PubMed ID: 38587486

Doi: 10.1083/jcb.202309140

Products & Services: Molecular Biology Reagents

Combined sensory, volatilome and transcriptome analyses identify a limonene terpene synthase as a major contributor to the characteristic aroma of a Coffea arabica L specialty coffee

Authors: Lison Marie, Jean-Christophe Breitler, Pingdwende Kader Aziz Bamogo, Mélanie Bordeaux, Séverine Lacombe, Maëlle Rios, Marc Lebrun, Renaud Boulanger, Eveline Lefort, Sunao Nakamura, Yudai Motoyoshi, Delphine Mieulet, Claudine Campa, Laurent Legendre, Benoît Bertrand

Journal: BMC Plant Biol

PubMed ID: 38566027

Doi: 10.1186/s12870-024-04890-3

Products & Services: Molecular Biology Reagents

The gene "degrees of kevin bacon" (dokb) regulates a social network behaviour in Drosophila melanogaster

Authors: Rebecca Rooke, Joshua J Krupp, Amara Rasool, Mireille Golemiec, Megan Stewart, Jonathan Schneider, Joel D Levine

Journal: Nat Commun

PubMed ID: 38688961

Doi: 10.1038/s41467-024-47499-8

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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang

Journal: J Transl Med

PubMed ID: 38610029

Doi: 10.1186/s12967-024-05159-x

Products & Services: Proteins, Expression, Isolation and Analysis

Visualization of the Association of Dimeric Protein Complexes on Specific Enhancers in the Salivary Gland Nuclei of Larva

Authors: Solène Vanderperre, Samir Merabet

Journal: Cells

PubMed ID: 38607052

Doi: 10.3390/cells13070613

Products & Services: Gene Synthesis

Systemic Effects of a Phage Cocktail on Healthy Weaned Piglets

Authors: Yankun Liu, Yan Lin, Weiyun Zhu

Journal: Biology (Basel)

PubMed ID: 38666883

Doi: 10.3390/biology13040271

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Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy

Authors: Kangkang Liu, Jing Peng, Yunfei Guo, Yiming Li, Xiang Qi, Dengyi Duan, Taipeng Li, Jianmin Li, Yuanjie Niu, Gang Han, Yang Zhao

Journal: ACS Nano

PubMed ID: 38680054

Doi: 10.1021/acsnano.4c01691

Products & Services: Proteins, Expression, Isolation and Analysis

The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance

Authors: Vijay Elakkya Vijayakumar, Mookambeswaran A Vijayalakshmi, Sebastien Lacroix-Desmazes, Krishnan Venkataraman

Journal: Folia Microbiol (Praha)

PubMed ID: 38683262

Doi: 10.1007/s12223-024-01166-z

Products & Services: Molecular Biology Reagents

Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy

Authors: Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong

Journal: J Med Chem

PubMed ID: 38624086

Doi: 10.1021/acs.jmedchem.3c02240

Products & Services: Gene Synthesis

The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Authors: Michele A Kutzler, Gina Cusimano, David Joyner, Emily Konopka, Roshell Muir, Philip Barnette, Melanie Guderian, Iván Del Moral-Sánchez, Ronald Derking, Tom Bijl, Jonne Snitselaar, Photis Rotsides, Kyra Woloszczuk, Matthew Bell, Gabriela Canziani, Irwin Chaiken, Ann Hessell, Yannic Bartsch, Rogier Sanders, Elias Haddad

Journal: Res Sq

PubMed ID: 38746176

Doi: 10.21203/rs.3.rs-4139764/v1

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A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Authors: Dan-Dan Zhou, Xiao-Tian Zhai, Lan-Wen Zhang, Zi-Hui Xie, Ying Wang, Yong-Su Zhen, Rui-Juan Gao, Qing-Fang Miao

Journal: NPJ Precis Oncol

PubMed ID: 38654141

Doi: 10.1038/s41698-024-00584-z

Products & Services: Proteins, Expression, Isolation and Analysis

Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia

Authors: Amaliris Guerra, Nolan Hamilton, Ariel Rivera, Perry Demsko, Shuling Guo, Stefano Rivella