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Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Authors: Emma Schuster, Nurmaa K Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F Almubarak, Valery Adorno-Cruz, David P Sullivan, Carolina Reduzzi, Allegra C Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P Siziopikou, Leonidas C Platanias, Ami Shah, William A Muller, William J Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu

Journal: Nature Communications

PubMed ID: 40818975

Doi: 10.1038/s41467-025-62862-z

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Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment

Authors: Mengyang Zhang, Shuyan Chen, Xiaoning Wu, Jialing Zhou, Bingqiong Wang, Tongtong Meng, Rongxuan Hua, Yameng Sun, Hong You, Wei Chen

Journal: Nature Communications

PubMed ID: 40830346

Doi: 10.1038/s41467-025-63006-z.

Products & Services: Protein Electrophoresis and Western

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Authors: Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine Price, Anand Mayasundari, Lei Yang, Anastasia H Bednarz, Sophie Machata, Tobias Graef, Denis Bartoschek, Vadim Demichev, Uli Ohmayer, Jun Yang, Henrik Daub, Zoran Rankovic

Journal: Nature Communications

PubMed ID: 40835825

Doi: 10.1038/s41467-025-62829-0.

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Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons

Authors: Liangzhen Dong, Jiayu Wang, Qing Xia

Journal: Nature Communications

PubMed ID: 40846860

Doi: 10.1038/s41467-025-62981-7.

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Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction

Authors: Xinming Wang, Yiming Zhong, Bei Qian, Shixing Huang, Qiang Long, Haonan Zhang, Qiang Zhao, Xiaofeng Ye

Journal: Materials today, Bio

PubMed ID: 40893381

Doi: 10.1016/j.mtbio.2025.102205

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Lung metastasis and recurrence is mitigated by CARmacrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Authors: Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang

Journal: Nature Communications

PubMed ID: 40759657

Doi: 10.1038/s41467-025-62506-2

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Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin.

Authors: Jing-Xiao Wang, Xiao-Yu Xu, Hong-Ke Dong, Yi-Ming Wang, Min Dai, Bing Zhou, Yue-Hua Li, Guo-Qing Zhu, Xiao-Qing Xiong

Journal: Journal of extracellular vesicles

PubMed ID: 40767027

Doi: 10.1002/jev2.70146.

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The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Journal: Journal of the American Chemical Society

PubMed ID: 40774922

Doi: doi.org/10.1021/jacs.5c08814

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Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens

Journal: Nature Cell Biology

PubMed ID: 40715440

Doi: 10.1038/s41556-025-01712-y

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Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou

Journal: Communications Biology

PubMed ID: 40783594

Doi: 10.1038/s42003-025-08607-6.

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Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants

Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji

Journal: Insect biochemistry and molecular biology

PubMed ID: 40543628

Doi: 10.1016/j.ibmb.2025.104351

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Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

Authors: Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen, Jie Cao, Zimin Zhang, Jun Ge, Huilin Yang, Liang Cheng

Journal: National Science Review

Doi: 10.1093/nsr/nwaf365

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A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo

Authors: Wei Zhang, Lizhen Yuan, Rui Liu, Yanbo Jing, Shijun Lin, Hao Fang, Yuxuan Li, Xiaohui Zhang, Jun Dai, Tao Liu, Fan Xia, Xiaoding Lou

Journal: J Am Chem Soc

PubMed ID: 40717291

Doi: 10.1021/jacs.5c07041

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Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain

Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini

Journal: The Journal of Biological Chemistry

PubMed ID: 40651610

Doi: 10.1016/j.jbc.2025.110470

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Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59

Authors: Yitong Xu, Huifeng Zhang, Ying Zhang, Jiutong Ma, Qiong Jia

Journal: Journal of chromatography. A

PubMed ID: 40382882

Doi: doi.org/10.1016/j.chroma.2025.466056

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A Novel Fluorescence Polarization Binding Assay for the Main Protease (M pro ) of SARS-CoV 2

Authors: Mackenzie K. Wyllie; Rayhan G. Biswas; Jyoti Vishwakarma; Morgan A. Esler; Joseph A. Rollie; Hideki Aihara; Reuben S. Harris; Daniel A. Harki

Journal: ACS pharmacology & translational science

PubMed ID: 41262570

Doi: 10.1021/acsptsci.5c00463

Identification of 14-3 3 Proteins as Binding Partners of TRP Channels

Authors: Nicol s Pe a-Vilches; Mariela Gonz lez-Avenda o; Nicole Soto-Garc a; Diego Maureira; Ian Silva; Javiera Avil s; El as Manr quez-Ben tez; Exequiel Medina; Oscar Cerda; Pablo Galaz-Davison; Ariela Vergara-Jaque

Journal: Journal of chemical information and modeling

PubMed ID: 41839059

Doi: 10.1021/acs.jcim.6c00092

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

Authors: Soumita Mukherjee; Somesh Roy; Shruti Mukherjee; Amaravadhi Harikishore; Anirban Bhunia; Atin K. Mandal

Journal: The Journal of Biological Chemistry

PubMed ID: 38325743

Doi: 10.1016/j.jbc.2024.105725

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin

Authors: Vikram Bhatia; Saeid Maghsoudi; Martha Hinton; Anjali Y. Bhagirath; Nisha Singh; Appalaraju Jaggupilli; Prashen Chelikani; Shyamala Dakshinamurti

Journal: Biology

PubMed ID: 37106773

Doi: 10.3390/biology12040572

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Engineering precision zebrafish alleles of human disease

Authors: Holly R. Thomas; Bradley K. Yoder; Matthew S. Alexander; John M. Parant

Journal: biorxiv

PubMed ID: 40475461

Doi: 10.1101/2025.05.18.654701

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Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Authors: Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana Saccon, Ramy Malty, Shahreen Amin, Sadhna Phanse, Thomson Patrick Joseph, Mara Zilocchi, Ali Hosseinnia, Zoe Istace, Maryam Hajikarimlou, Sakib Abrar, Jade Fisher, Raelynn Brassard, Ranawaka Perera, Anil Kumar, Hiroyuki Aoki, Matineh Rahmatbakhsh, Matthew Jessulat, Darwyn Kobasa, Frank Dehne, Bhanu Prasad, Alla Gagarinova, M Joanne Lemieux, Alan Cochrane, Walid A Houry, Khaled A Aly, Ashkan Golshani, Mohan Babu

Journal: Nature Communications

PubMed ID: 40593736

Doi: 10.1038/s41467-025-60949-1

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Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

Authors: Victoria Gonzalez, Briallen Lobb, Jacob Côté, Arkadeb Bhuinya, Adriana G Tubb, Stephen S Nuthalapati, Akarin Asavajaru, Yan Zhou, Vikram Misra, Darryl Falzarano, Trevor R Sweeney, Sophie M C Gobeil, Linfa Wang, Andrew C Doxey, Arinjay Banerjee

Journal: Nature Communications

PubMed ID: 40593754

Doi: 10.1038/s41467-025-61254-7

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CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage

Authors: Justin Van Riper, Arleth O Martinez-Claros, Lie Wang, Hannah E Schneiderman, Sweta Maheshwari, Monica C Pillon

Journal: Nature Communications

PubMed ID: 40592880

Doi: 10.1038/s41467-025-61091-8

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The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Authors: Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P Watts, Masato T Kanemaki, Antony W Oliver, Laurence H Pearl, Shin-Ichiro Hiraga, Anne D Donaldson

Journal: Nature Communications

PubMed ID: 40595496

Doi: 10.1038/s41467-025-60817-y

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New molecular components of high and low affinity iron import systems in Drosophila

Authors: Sattar Soltani, Minyi Yan, Qingxuan Yu, Areeg Abd Elhafiz, Erika Pfriem, Samuel M Webb, Thomas Kroll, Jahir Marceliano Bahena Lopez, Fanis Missirlis, Kirst King-Jones

Journal: Nature Communications

PubMed ID: 40592826

Doi: 10.1038/s41467-025-60758-6

Products & Services: PCR Cloning and Subcloning

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells

Authors: Ines Sturmlechner, Abhinav Jain, Bin Hu, Rohit R Jadhav, Wenqiang Cao, Hirohisa Okuyama, Lu Tian, Cornelia M Weyand, Jörg J Goronzy

Journal: Nature Communications

PubMed ID: 40640147

Doi: 10.1038/s41467-025-61627-y

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Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes

Authors: Anaxi Houbaert, Valérie Denervaud Tendon, Lukas Hoermayer, Nicholas Morffy, Lucia C Strader, Niko Geldner

Journal: Nature Communications

PubMed ID: 40670339

Doi: 10.1038/s41467-025-61742-w

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A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection

Authors: Christopher J Corcoran, Bonnie J Cuthbert, David G Glanville, Mailyn Terrado, Diana Valverde Mendez, Benjamin P Bratton, Daniel E Schemenauer, Valerie L Tokars, Thomas G Martin, Lawrence W Rasmussen, Matthew C Madison, Andrew F Maule, Joshua W Shaevitz, Boo Shan Tseng, Julian P Whitelegge, Catherine Putonti, Amit Gaggar, Jordan R Beach, Jonathan A Kirk, Alfonso Mondragón, Abby R Kroken, Jonathan P Allen, Celia W Goulding, Andrew T Ulijasz

Journal: Nature Communications

PubMed ID: 40681494

Doi: 10.1038/s41467-025-61469-8

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Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis

Authors: Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J Richards, Tingfei Chen, Jingjing Wu, Ronald C Bruntz, Marisa E Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo

Journal: Nature Communications

PubMed ID: 40691173

Doi: 10.1038/s41467-025-61973-x

Products & Services: PCR Cloning and Subcloning

CD19-ReTARGTPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies

Authors: Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers

PubMed ID: 40723184

Products & Services: Gene Synthesis

Deficiency of IFNAR1 Increases the Production of Influenza Vaccine Viruses in MDCK Cells

Authors: Qi Wang, Tuanjie Chen, Mengru Feng, Mei Zheng, Feixia Gao, Chenchen Qiu, Jian Luo, Xiuling Li

Journal: Viruses-Basel

Doi: 10.3390/v17081097

Products & Services: Nucleic Acid Purification

A Carbamoyl N-Methyltransferase Catalyzes N-Methylation of the Primary Amide in Ansacarbamitocin Biosynthesis

Authors: Zhongyue Li, Wanting Yang, Zhonglin Sun, Haoxin Wang, Chunhua Lu, Deyu Zhu, Yuemao Shen

Journal: Journal of the American Chemical Society

PubMed ID: 40601550

Doi: 10.1021/jacs.5c05398

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Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii

Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 40616507

Doi: doi.org/10.1021/acs.jafc.5c03402

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An integrated electrochemical nanodevice for single-cell MiRNA-155 detection and drug evaluation

Authors: Zhuo Li , Zhaohan Wang , Jun Chen , Yafeng Wu

Journal: BIOSENSORS & BIOELECTRONICS

PubMed ID: 40695112

Doi: 10.1016/j.bios.2025.117804

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Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Authors: Dapeng Li; Yuanfan Li; Jie Cang; Xianwen Yan; Feipeng Wu; Xuan Sun; Wenchao Zhang

Journal: Frontiers in pharmacology

PubMed ID: 40264674

Doi: 10.3389/fphar.2025.1584245

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Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Authors: Dapeng Li; Yuanfan Li; Jie Cang; Xianwen Yan; Feipeng Wu; Xuan Sun; Wenchao Zhang

Journal: Frontiers in pharmacology

PubMed ID: 40264674

Doi: 10.3389/fphar.2025.1584245

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Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Authors: Austin Tedman; Muskan Goel; Sohan Shah; Mathew K. Howard; Laura M. Chamness; Antonio Bonifasi; Ismalia Adams; Jacklyn M. Gallagher; Wesley D. Penn; Katarina Nemec; Eli F. McDonald; Brianna N. Corman; J. Paul Robinson; Carol Beth Post; Patricia L. Clark; M. Madan Babu; Aashish Manglik; Charles P. Kuntz; Willow Coyote-Maestas; Jonathan P. Schlebach

Journal: biorxiv

PubMed ID: 41000614

Doi: 10.1101/2025.09.19.677468

A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease

Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao

Journal: Advanced Science

PubMed ID: 40685690

Doi: 10.1002/advs.202509419

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ZEB2 is a master switch controlling the tumor-associated macrophage program

Authors: Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher-Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan, Kiara Freitag, Ido Yofe, Vladimir Yutkin, Pierre Boyeau, Can Ergen, Justin Hong, Kfir Mazuz, Yuxiao Liu, Kangming Chen, Rony Dahan, Marcin Kortylewski, Nir Yosef, Assaf Weiner, Ido Amit

Journal: Cancer Cell

PubMed ID: 40215981

Doi: 10.1016/j.ccell.2025.03.021

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Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma

Authors: Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue

Journal: ACS Nano

PubMed ID: 40698543

Doi: 10.1021/acsnano.5c08928

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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

Authors: Chen Guo, Zhilin Long, Peng Lin, Yinan Shen, Yiye Zhong, Jingjing Qian, Jichuan Yu, Weixi Zhao, Fuyi Liu, Yiling Ma, Jian Zheng, Jiayao Yang, Shuai Zhao, Xiaojuan Ran, Zhen Xia, Congying Wu, Yujia Cai, Chen Wang, Qi Xie

Journal: Cell Reports Medicine

PubMed ID: 40744020

Doi: 10.1016/j.xcrm.2025.102258

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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Authors: Benjamin Bourgeois, Emil Spreitzer, Daniel Platero-Rochart, Margret Paar, Qishun Zhou, Sinem Usluer, Peter L J de Keizer, Boudewijn M T Burgering, Pedro A Sánchez-Murcia, Tobias Madl

Journal: Nature Communications

PubMed ID: 40593617

Doi: 10.1038/s41467-025-60844-9

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Biohybrid-based pyroelectric bio-denitrification driven by temperature fluctuations

Authors: Jie Ye, Shuhui Wang, Chaohui Yang, Zhenhao Zuo, Wenzhi Gu, Baogang Zhang, Shungui Zhou

Journal: Nature Communications

PubMed ID: 40595581

Doi: 10.1038/s41467-025-60908-w

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Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA

Authors: Menglu Hu, Bingni Zhang, Yuanyue Shan, Feng Cao, Yihui Wang, Weiwei Qi, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, Tian Tian, Wei Xie, Mingfeng Zhang, Fang Liang, Duanqing Pei, Xiaoming Zhou

Journal: Nature Communications

PubMed ID: 40593724

Doi: 10.1038/s41467-025-61094-5

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Oropouche virus infects human trophoblasts and placenta explants

Authors: Christina J Megli, Rebecca K Zack, Jackson J McGaughey, Ryan M Hoehl, Taylor Snisky, Amy L Hartman, Cynthia M McMillen

Journal: Nature Communications

PubMed ID: 40593852

Doi: 10.1038/s41467-025-61138-w

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An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies

Authors: Bakar Hassan, Monika Chandravanshi, Martin Y Ng, Hitendra Negi, Brice A P Wilson, Kylie J Walters

Journal: Nature Communications

PubMed ID: 40595513

Doi: 10.1038/s41467-025-60843-w

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Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Authors: Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara

Journal: Nature Communications

PubMed ID: 40610448

Doi: 10.1038/s41467-025-61312-0

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Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors

Authors: Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A Dunbar, Shiyi Wu, Marit J van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N de Menezes, Emily B Derrick, Cheok Weng Chan, Kirsten L Todd, Jack D Chan, Jasmine Li, Junyun Lai, Emma V Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A Parish, Christina Mølck, Gregory D Stewart, Lev Kats, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature Communications

PubMed ID: 40610421

Doi: 10.1038/s41467-025-59021-9

Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)-vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial

Authors: Paul Spearman, Hong Jin, Peng Xiao, Kristeene Knopp, Henry Radziewicz, Marinka Tellier, Sasha E Larsen, Bryan J Berube, Xiao Song, Jamie Kidd, Karnail Singh, Zhuo Li, Maria Cristina Gingerich, Samuel Wu, Susan P John, Angela Branche, Ann R Falsey, Rhea Coler, Francois J Villinger, Biao He

Journal: SCIENCE ADVANCES

PubMed ID: 40614182

Doi: 10.1126/sciadv.adw0896

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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Xiuxia Gao, Yannan Wang, Wenping Shi, Roger D Kornberg, Heqiao Zhang

Journal: Cell

PubMed ID: 40628260

Doi: 10.1016/j.cell.2025.06.017

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