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A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro

Authors: Jing Sun, Deheng Sun, Qi Yang, Dong Wang, Jingjing Peng, Hu Guo, Xiaoyu Ding, Zhao Chen, Bin Yuan, Yan A Ivanenkov, Jinwei Yuan, Bogdan A Zagribelnyy, Yiyun He, Jingyi Su, Ling Wang, Jielin Tang, Zhun Li, Rong Li, Taotao Li, Xiaoyu Hu, Xing Liang, Airu Zhu, Peilan Wei, Yaya Fan, Sang Liu, Jie Zheng, Xin Guan, Alex Aliper, Minglei Yang, Dmitry S Bezrukov, Zhanhong Xie, Victor A Terentiev, Guilin Peng, Daniil A Polykovskiy, Alexander S Malyshev, Maxim N Malkov, Qingsong Zhu, Alán Aspuru-Guzik, Xiao Ding, Xin Cai, Man Zhang, Jingxian Zhao, Nanshan Zhong, Feng Ren, Xinwen Chen, Alex Zhavoronkov, Jincun Zhao

Journal: Nature Communications

PubMed ID: 40374668

Doi: 10.1038/s41467-025-59870-4

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Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor

Authors: Yang Wang, Ming Liu, Shan Wang, Xinyi Mai, Xi Wang, Fei Teng, Tianrui Lyu, Ming-Yuan Su, Goran Stjepanovic

Journal: SCIENCE ADVANCES

PubMed ID: 40408472

Doi: 10.1126/sciadv.adu8708

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Expanding the σ54-dependent transcription process with orthogonal designs

Authors: Yiheng Liu, Shuyi Cai, Ziyi Zhang, Zhuoting Xie, Chenyue Guo, Yi-Ping Wang, Jianguo Yang

Journal: Nucleic Acids Research

PubMed ID: 40401558

Doi: 10.1093/nar/gkaf442

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Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Authors: Sabrina J Fletcher, Eugenia S Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh

Journal: SCIENCE ADVANCES

PubMed ID: 40378201

Doi: 10.1126/sciadv.adv1286

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Authors: Sifeng Gu , Zsolt Bodai , Rachel A Anderson , Hei Yu Annika So , Quinn T Cowan , Alexis C Komor

Journal: Nature Communications

PubMed ID: 40394064

Doi: 10.1038/s41467-025-59948-z

Accurate Mapping of 5-Glyceryl-methylcytosine Using Nanopore Sequencing

Authors: Linting Wang, Baodan He, Zixin Wang, Liting Kang, Jianhuang Xue, Shuanghong Yan

Journal: Anal Chem

PubMed ID: 40314134

Doi: 10.1021/acs.analchem.5c00845

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Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis

Authors: Zhike Chen, Jian Yang, Qiang Zhang, Weibiao Zeng, Yi Liu, Wenxuan Hu, Linfu Chen, Jingjing Shen, Yu Miao, Zhisheng Xiao, Zhiqiang Wu, He Wang, Hui Shen, Cheng Ding, Qian Chen, Jun Zhao, Yang Yang

Journal: SCIENCE ADVANCES

PubMed ID: 40305619

Doi: 10.1126/sciadv.adv9571

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Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase-Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Authors: Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu

Journal: Adv Sci (Weinh)

PubMed ID: 40365750

Doi: 10.1002/advs.202505310

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De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses

Authors: Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chen

Journal: Cell

PubMed ID: 40436014

Doi: 10.1016/j.cell.2025.05.003

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Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence

Authors: Heng Zhang, Nana Cui, Xiong Ma, H Eric Xu

Journal: Cell Research

PubMed ID: 40108449

Doi: 10.1038/s41422-025-01090-y

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N 6-methyladenosine modifications stabilize phosphate starvation response–related mRNAs in plant adaptation to nutrient-deficient stress

Authors: Kai Liu, Xiaojia Wang, Jingyi Wang, Shuman Wang, Haiyan Bai, Weiguo Dong, Lulu Qiao, Qiongli Jin, Zhonghui Zhang, Guan-Zheng Luo, Zhiye Wang

Journal: Nature Communications

PubMed ID: 40312414

Doi: 10.1038/s41467-025-59331-y

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Authors: Jitong Zhou, Meng Gao, Shikun Zhang, Wing-Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma

Journal: Advanced Science

PubMed ID: 40344394

Doi: 10.1002/advs.202501730

Products & Services: Protein Electrophoresis and Western

FLT201, a novel liver-directed AAV gene therapy candidate for Gaucher disease type 1

Authors: Fabrizio Comper, Carlos J Miranda, Benjamin Liou, Tihomir Dodev, Jey M Jeyakumar, Miriam Canavese, Clement Cocita, Khashayar Khoshrou, Gustavo Tiscornia, Elisa Chisari, Emmaline Stotter, Erald Shehu, Sudharsan Sridharan, I-Mei Yu, Jalpa Pandya, Jaminder Khinder, Natalie Northcott, Petya Kalcheva, Samantha Correia, Ying Sun, Allison P Dane, Rose Sheridan, Amit C Nathwani, Romuald Corbau

Journal: Molecular Therapy

PubMed ID: 40340248

Doi: 10.1016/j.ymthe.2025.05.003

Products & Services: Gene Synthesis

Mac-1 regulates disease stage-specific immunosuppression via the nitric oxide pathway in autoimmune disease

Authors: Wei Wang , Chunzhang Cao , Vishnuprabu Durairaj Pandian , Haofeng Ye , Hongxia Chen , Li Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 40344054

Doi: 10.1126/sciadv.ads3728

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Heterologous synthesis of a simplified nitrogenase analog in Escherichia coli

Authors: Yiling A Liu, Chi Chung Lee, Kamil Górecki, Martin T Stiebritz, Calder Duffin, Joseph B Solomon, Markus W Ribbe, Yilin Hu

Journal: SCIENCE ADVANCES

PubMed ID: 40315313

Doi: 10.1126/sciadv.adw6785

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Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapy

Authors: Yuwei Li, Maoxin Fang, Haotian Yu, Xianglei Wang, Shiyao Xue, Zeze Jiang, Zixuan Huang, Shaoqin Rong, Xiaoli Wei, Zhigang Lu, Min Luo

Journal: Nature Communications

PubMed ID: 40404668

Doi: 10.1038/s41467-025-59977-8

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T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Authors: Ji-Li Chen, Beibei Wang, Yongxu Lu, Elie Antoun, Olivia Bird, Philip G Drennan, Zixi Yin, Guihai Liu, Xuan Yao, Maya Pidoux, Adam Bates, Deshni Jayathilaka, Junyuan Wang, Brian Angus, Sally Beer, Alexis Espinosa, J Kenneth Baillie, Malcolm G Semple, ISARIC4C Investigators, Timothy Rostron, Craig Waugh, Paul Sopp, Julian C Knight, James N Fullerton, Mark Coles, Geoffrey L Smith, Alexander J Mentzer, Yanchun Peng, Tao Dong

Journal: Nature Communications

PubMed ID: 40348752

Doi: 10.1038/s41467-025-59370-5

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GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization

Authors: Luca Franchini , Joseph J Porter , John D Lueck , Cesare Orlandi

Journal: Nature Communications

PubMed ID: 40374633

Doi: 10.1038/s41467-025-59850-8

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Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells

Authors: James R W Conway, Omkar Joshi, Jasmin Kaivola, Gautier Follain, Michalis Gounis, David Kühl, Johanna Ivaska

Journal: Nature Cell Biology

PubMed ID: 40419795

Doi: 10.1038/s41556-025-01663-4

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PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Journal: Signal Transduct Target Ther

PubMed ID: 40393983

Doi: 10.1038/s41392-025-02250-7

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Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

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Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing

Authors: Zhen Liu, Jiacai Wu, Ning Wang, Yongqi Lin, Ruiteng Song, Min Zhang, Bin Li

Journal: Nature Communications

PubMed ID: 40335474

Doi: 10.1038/s41467-025-59501-y

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Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2-dependent statine pathway

Authors: Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting, Rolf Müller, Chengzhang Fu

Journal: Nature Communications

PubMed ID: 40374670

Doi: 10.1038/s41467-025-59785-0

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Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease

Authors: Haozhou Tan, Qianru Zhang, Kyriakos Georgiou, Siyu Zhang, Kan Li, George Lambrinidis, Antonios Kolocouris, Xufang Deng, Jun Wang

Journal: Nature Communications

PubMed ID: 40379662

Doi: 10.1038/s41467-025-59922-9

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RabE1a- and SEC10b-mediated exocytosis and AP2β-mediated endocytosis are involved in the intracellular transport of tobamoviruses

Authors: Hua-Yu Ma, Yu Kong, Chao Geng, Yan-Ping Tian, Jun Jiang, Zhi-Yong Yan, Xiang-Dong Li

Journal: Plant Biotechnology Journal.

PubMed ID: 40408557

Doi: 10.1111/pbi.70138

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Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery

Authors: Xingdi Cheng, Xia Zheng, Kun Tao, Haonan Huo, Zhang Liu, Xueguang Lu, Jianjun Wang

Journal: Nature Communications

PubMed ID: 40394015

Doi: 10.1038/s41467-025-60040-9

Products & Services: Gene Synthesis

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Authors: Alexandra Teslenko , Beat Fierz

Journal: SCIENCE ADVANCES

PubMed ID: 40397729

Doi: 10.1126/sciadv.adt7013

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Stomata-targeted nanocarriers enhance plant defense against pathogen colonization

Authors: Suppanat Puangpathumanond, Heng Li Chee, Cansu Sevencan, Xin Yang, On Sun Lau, Tedrick Thomas Salim Lew

Journal: Nature Communications

PubMed ID: 40410152

Doi: 10.1038/s41467-025-60112-w

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An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Authors: Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin-Yu Chen, Chunhua Li, Lixin Ma

Journal: Advanced Science

PubMed ID: 40364725

Doi: 10.1002/advs.202416631

Structure and mechanism of human vesicular polyamine transporter

Authors: Yi Guo, Ge Yang, Haijiao Liu, Jin Chai, Jie Chen, John Shanklin, Qun Liu, Bin Liu, Min Lu

Journal: Nature Communications

PubMed ID: 40319071

Doi: 10.1038/s41467-025-59549-w

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A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress

Authors: Suman Pokhrel, Gwangbeom Heo, Irimpan Mathews, Shun Yokoi, Tsutomu Matsui, Ayori Mitsutake, Soichi Wakatsuki, Daria Mochly-Rosen

Journal: Nature Communications

PubMed ID: 40328741

Doi: 10.1038/s41467-025-59434-6

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Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Authors: Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Jian He, Hangchen Hu, Wenfeng Zhao, Qiang Shao, Minjun Li, Qiang Zhao, Yechun Xu

Journal: Nature Communications

PubMed ID: 40341069

Doi: 10.1038/s41467-025-59432-8

Products & Services: Protein Electrophoresis and Western

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

Authors: Chendi Li, Mohammed Usman Syed, Anahita Nimbalkar, Yi Shen, Melissa D Vieira, Cameron Fraser, Zintis Inde, Xingping Qin, Jian Ouyang, Johannes Kreuzer, Sarah E Clark, Grace Kelley, Emily M Hensley, Robert Morris, Raul Lazaro, Brian Belmonte, Audris Oh, Makeba Walcott, Christopher S Nabel, Sean Caenepeel, Anne Y Saiki, Karen Rex, J Russell Lipford, Rebecca S Heist, Jessica J Lin, Wilhelm Haas, Kristopher Sarosiek, Paul E Hughes, Aaron N Hata

Journal: Nature Communications

PubMed ID: 40316540

Doi: 10.1038/s41467-025-58753-y

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Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants

Authors: Mande Xue, Lijun Ma, Xiaoyi Li, Huairen Zhang, Fengyue Zhao, Qian Liu, Danhua Jiang

Journal: Nature Communications

PubMed ID: 40355503

Doi: 10.1038/s41467-025-59711-4

Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence

Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang

Journal: ACS catalysis

Doi: doi.org/10.1021/acscatal.5c01673

Products & Services: Gene Synthesis Codon Optimization

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics

Authors: Daniel A Ciulla, Patricia K Dranchak, Mahesh Aitha, Renier H P van Neer, Divia Shah, Ravi Tharakan, Kelli M Wilson, Yuhong Wang, John C Braisted, James Inglese

Journal: nature COMMUNICATION

PubMed ID: 40346061

Doi: 10.1038/s41467-025-59658-6

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Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Authors: Thomas H Ambrosi, Sahar Taheri, Kun Chen, Rahul Sinha, Yuting Wang, Ethan J Hunt, L Henry Goodnough, Matthew P Murphy, Holly M Steininger, Malachia Y Hoover, Franco Felix, Kelly C Weldon, Lauren S Koepke, Jan Sokol, Daniel Dan Liu, Liming Zhao, Stephanie D Conley, Wan-Jin Lu, Maurizio Morri, Norma F Neff, Noelle L Van Rysselberghe, Erika E Wheeler, Yongheng Wang, J Kent Leach, Augustine Saiz, Aijun Wang, George P Yang, Stuart Goodman, Julius A Bishop, Michael J Gardner, Derrick C Wan, Irving L Weissman, Michael T Longaker, Debashis Sahoo, Charles K F Chan

Journal: Cell Stem Cell

PubMed ID: 40118065

Doi: 10.1016/j.stem.2025.02.013

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Ferritin From Striped Stem Borer (Chilo suppressalis) Oral Secretion Acts as an Effector Helping to Maintain Iron Homoeostasis and Impair Defenses in Rice

Authors: Shan Yu, Shuai Li, Jing Li, Chen-Yang Wang, Lei Yang, Jing Li, Yue Meng, Xin-Yang Tan, Mao-Feng Jing, Guang-Hua Luo, Ji-Chao Fang, Rui Ji

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39812459

Doi: 10.1111/pce.15386

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C-mannosyltransferase DPY19L1L-mediated Reissner Fiber formation is critical for zebrafish (Danio rerio) body axis straightening

Authors: Guiyou Tian, Lirong Huang, Zhaopeng Xu, Chen Lu, Wei Yuan, Yulin Wu, Zhipeng Liao, Jia Gao, Qiang Luo, Bo Cheng, Xinjun Liao, Huiqiang Lu

Journal: SCIENCE ADVANCES

PubMed ID: 40344050

Doi: 10.1126/sciadv.adv2032

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Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

Authors: Justin M Waldern, Colin Taylor, Catherine A Giannetti, Patrick S Irving, Scott R Allen, Mingyi Zhu, Rolf Backofen, Dave Mathews, Kevin M Weeks, Alain Laederach

Journal: Nucleic Acids Research

PubMed ID: 39713457

Doi: 10.1101/2024.12.13.628372

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FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Authors: Michal Beffinger, Linda Schellhammer, Betül Taskoparan, Sereina Deplazes, Ulisse Salazar, Nazanin Tatari, Frauke Seehusen, Leopold von Balthazar, Carl Philipp Zinner, Sabine Spath, Tala Shekarian, Marie-Françoise Ritz, Marta McDaid, Pascal Egloff, Iwan Zimmermann, Hideho Okada, E Sally Ward, Jack Rohrer, Markus A Seeger, Thorsten Buch, Gregor Hutter, Johannes Vom Berg

Journal: Nature Communications

PubMed ID: 40404625

Doi: 10.1038/s41467-025-59971-0

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Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense

Authors: Wen-Hao Han, Feng-Bin Zhang, Shun-Xia Ji, Kai-Lu Liang, Jun-Xia Wang, Xiao-Ping Fan, Shu-Sheng Liu, Xiao-Wei Wang

Journal: SCIENCE ADVANCES

PubMed ID: 40344064

Doi: 10.1126/sciadv.adu5141

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DDX3 Regulates the Cap-Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Authors: Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming-An Sun, Yanhua Li

Journal: Advanced Science

PubMed ID: 40344524

Doi: 10.1002/advs.202502493

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

Authors: F Li, A S Phadte, M Bhatia, S Barndt, A R Monte Carlo Iii, C-F D Hou, R Yang, S Strock, A Pluciennik

Journal: Nature Communications

PubMed ID: 40368897

Doi: 10.1038/s41467-025-59323-y

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The ALX4 dimer structure provides insight into how disease alleles impact function

Authors: Brittany Cain , Zhenyu Yuan , Evelyn Thoman, Rhett A Kovall , Brian Gebelein

Journal: Nature Communications

PubMed ID: 40410151

Doi: 10.1038/s41467-025-59728-9

LRM3 positively regulates stem lodging resistance by degradating MYB6 transcriptional repressor in soybean

Authors: Yongheng Ye, Zhiyuan Cheng, Xinjing Yang, Suxin Yang, Kuanqiang Tang, Hui Yu, Jinshan Gao, Yaohua Zhang, Jiantian Leng, Wei Zhang, Ye Zhang, Moran Bu, Zhengwei Liang, Zhicheng Dong, Zhonghui Zhang, Xianzhong Feng

Journal: Plant Biotechnology Journal.

PubMed ID: 40333576

Doi: 10.1111/pbi.70124

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An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Authors: Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E Low, Michael V Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Journal: Nature Communications

PubMed ID: 40312392

Doi: 10.1038/s41467-025-59353-6

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Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

Authors: Louis C Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Pei-Pei Hsieh, Salman Mustfa, George Thom, Sandra Wimberger, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

Journal: Nature Communications

PubMed ID: 40341582

Doi: 10.1038/s41467-025-59708-z

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Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

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TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis

Authors: Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li

Journal: International journal of biological sciences

PubMed ID: 40520017

Doi: 10.7150/ijbs.108832

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