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Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae

Authors: Ana Falcón, Susana Martínez-Pulgarín, Sergi López-Serrano, Edel Reytor, Miguel Cid, Maria Del Carmen Nuñez, Lorena Córdoba, Ayub Darji, José M Escribano

Journal: Viruses

PubMed ID: 38932122

Doi: 10.3390/v16060829

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AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration

Authors: Liyan Zhang, Xin Chen, Xinlin Wang, Yinyi Zhou, Yuan Fang, Xingliang Gu, Ziyu Zhang, Qiuhan Sun, Nianci Li, Lei Xu, Fangzhi Tan, Renjie Chai, Jieyu Qi

Journal: Adv Sci (Weinh)

PubMed ID: 38810137

Doi: 10.1002/advs.202304551

Products & Services: Proteins, Expression, Isolation and Analysis

Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Authors: Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Journal: Biochemistry

PubMed ID: 38690768

Doi: 10.1021/acs.biochem.4c00109

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Manganese-dependent transcription regulation by MntR and PerR in Thermus thermophilus HB8

Authors: John K Barrows, Kamya A Stubbs, Irina F Padilla-Montoya, Thomas C Leeper, Michael W Van Dyke

Journal: Mol Microbiol

PubMed ID: 38735869

Products & Services: Nucleic Acid Purification & Analysis

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

Authors: Lisa Schmidt, Christian Tüting, Fotis L Kyrilis, Farzad Hamdi, Dmitry A Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T Stubbs, Andrea Sinz, Panagiotis L Kastritis

Journal: Commun Biol

PubMed ID: 38730276

Doi: 10.1038/s42003-024-06204-7

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Combinatorial Metabolic Engineering for Improving Betulinic Acid Biosynthesis in

Authors: Mei Tang, Xianhao Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu

Journal: ACS Synth Biol

PubMed ID: 38748665

Doi: 10.1021/acssynbio.4c00104

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and gene-edited human induced pluripotent stem cells for dissecting the functional roles of -GlcNAcylation in hematopoiesis

Authors: Sudjit Luanpitpong, Kantpitchar Tangkiettrakul, Xing Kang, Pimonwan Srisook, Jirarat Poohadsuan, Parinya Samart, Phatchanat Klaihmon, Montira Janan, Chanchao Lorthongpanich, Chuti Laowtammathron, Surapol Issaragrisil

Journal: Front Cell Dev Biol

PubMed ID: 38752196

Doi: 10.3389/fcell.2024.1361943

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Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution

Authors: Shannon Ward, Alex Childs, Ceri Staley, Christopher Waugh, Julie A Watts, Anna M Kotowska, Rahul Bhosale, Aditi N Borkar

Journal: Nat Commun

PubMed ID: 38777820

Doi: 10.1038/s41467-024-48694-3

Products & Services: Molecular Biology Reagents

Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

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Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

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Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

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A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Production of VP3-only virus-like particles of Adeno-associated virus 2 in E coli cells

Authors: Chengyu Fu, Shruthi Gobbooru, Ashley T Martino, Woon-Kai Low

Journal: Protein Expr Purif

PubMed ID: 38754753

Doi: 10.1016/j.pep.2024.106502

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Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

Products & Services: Codon Optimization

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection

Authors: Li An , Qianwen Zhai , Keyu Tao , Yingcai Xiong , Weiying Ou , Ziwei Yu , Xingyu Yang , Jianjian Ji , Mengjiang Lu

Journal: Phytomedicine

PubMed ID: 38797031

Doi: 10.1016/j.phymed.2024.155761

Products & Services: Proteins, Expression, Isolation and Analysis

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA

Authors: Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu & Yi Yang

Journal: nature chemical biology

PubMed ID: 38783134

Doi: 10.1038/s41589-024-01629-x

Products & Services: Single-Stranded DNA Synthesis

F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Authors: Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H Wysocki, Mark P Foster

Journal: biorxiv

PubMed ID: 38746386

Doi: 10.1101/2024.05.02.592192

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system in

Authors: Shihua Yu, Huoqing Zheng, Xiaogang Ye, Xiangping Dai, Xinqiu Wang, Shuo Zhao, Xiaoyan Dai, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38832132

Doi: 10.3389/fbioe.2024.1399629

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LINE-1 retrotransposons contribute to mouse PV interneuron development

Authors: Gabriela O Bodea, Juan M Botto, Maria E Ferreiro, Francisco J Sanchez-Luque, Jose de Los Rios Barreda, Jay Rasmussen, Muhammed A Rahman, Laura R Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J Da Costa Guevara, Linda Cumner, Charles C Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H C Kempen, Chloe J Love, Karabi Saha, Lucy M Palmer, Adam D Ewing, Dhanisha J Jhaveri, Sandra R Richardson, Anthony J Hannan, Geoffrey J Faulkner

Journal: Nat Neurosci

PubMed ID: 38773348

Doi: 10.1038/s41593-024-01650-2

Products & Services: Molecular Biology Reagents

Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Authors: Jean-Pierre Bellier, Andrea Roman, Caitlyn Christiano, Juliana Au Anzai, Stephanie Moreno, Emily C Campbell, Lucas Godwin, Amy Li, Alan Chen, Sarah M Alan, Adriana Saba, Han Bin Yoo, Hyun-Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: biorxiv

PubMed ID: 38746192

Doi: 10.1101/2024.05.01.591892

Products & Services: Proteins, Expression, Isolation and Analysis

Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren's syndrome in mice by promoting TEC kinase degradation

Authors: Ya-Qi Yang, Yi-Jun Liu, Wen-Xuan Qiao, Wei Jin, Shun-Wei Zhu, Yu-Xi Yan, Qiong Luo, Qiang Xu

Journal: Acta Pharmacol Sin

PubMed ID: 38744938

Doi: 10.1038/s41401-024-01288-7

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A ferritin nanoparticle vaccine based on the hemagglutinin extracellular domain of swine influenza A (H1N1) virus elicits protective immune responses in mice and pigs

Authors: Pan Tang, Enhui Cui, Jinghua Cheng, Benqiang Li, Jie Tao, Ying Shi, Jiajie Jiao, Enqi Du, Jingyu Wang, Huili Liu

Journal: Front Immunol

PubMed ID: 38835763

Doi: 10.3389/fimmu.2024.1361323

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Authors: Garrett L Schey, Emily R Hildebrandt, You Wang, Safwan Diwan, Holly A Passetti, Gavin W Potts, Andrea M Sprague-Getsy, Ethan R Leoni, Taylor S Kuebler, Yuk Y Sham, James L Hougland, Lorena S Beese, Walter K Schmidt, Mark D Distefano

Journal: Int J Mol Sci

PubMed ID: 38791363

Doi: 10.3390/ijms25105324

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Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells

Authors: Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E Louch, Cathrine Rein Carlson

Journal: Cells

PubMed ID: 38891079

Doi: 10.3390/cells13110947

Products & Services: Recombinant Proteins

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

Authors: Muneera Vakayil, Aisha Y Madani, Maha V Agha, Yasser Majeed, Shahina Hayat, Shameem Yonuskunju, Yasmin Ali Mohamoud, Joel Malek, Karsten Suhre, Nayef A Mazloum

Journal: Sci Rep

PubMed ID: 38789534

Doi: 10.1038/s41598-024-62508-y

Products & Services: Molecular Biology Reagents

Development of a nucleoside-modified mRNA vaccine against clade 2344b H5 highly pathogenic avian influenza virus

Authors: Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H Y Fan, Anthony T Phan, Christopher A Hunter, Richard J Webby, Drew Weissman, Scott E Hensley

Journal: Nat Commun

PubMed ID: 38782954

Doi: 10.1038/s41467-024-48555-z

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Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in

Authors: Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

Journal: Synth Syst Biotechnol

PubMed ID: 38817827

Doi: 10.1016/j.synbio.2024.05.010

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Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I Loch, Marcin Surmiak

Journal: Molecules

PubMed ID: 38792133

Doi: 10.3390/molecules29102272

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Biophysical insights into the dimer formation of human Sirtuin 2

Authors: Noa Suzuki, Tsuyoshi Konuma, Takahisa Ikegami, Satoko Akashi

Journal: Protein Sci

PubMed ID: 38647411

Doi: 10.1002/pro.4994

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Construction and in vitro characterisation of virus-vectored immunocontraceptive candidates derived from felid alphaherpesvirus 1

Authors: Ellen Cottingham, Thurid Johnstone, Paola K Vaz, Carol A Hartley, Joanne M Devlin

Journal: Vaccine

PubMed ID: 38824082

Doi: 10.1016/j.vaccine.2024.05.047

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Combined effect of SAR-endolysin LysKpV475 with polymyxin B and bacteriophage phSE-5

Authors: Marco Gontijo, Mateus Pereira Teles, Hugo Martins Correia, Genesy Pérez Jorge, Isabella Carolina Rodrigues Santos Goes, Anthony Jhoao Fasabi Flores, Márcia Braz, Lucas de Moraes Ceseti, Priscila Zonzini Ramos, Ivan Rosa E Silva, Pedro Marcus Pereira Vidigal, Jörg Kobarg, Rafael Miguez Couñago, Cristina Elisa Alvarez-Martinez, Carla Pereira, Carmen S R Freire, Adelaide Almeida, Marcelo Brocchi

Journal: Microbiology (Reading)

PubMed ID: 38739436

Doi: 10.1099/mic.0.001462

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A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Authors: Yashavantha L Vishweshwaraiah, Brianna Hnath, Jian Wang, Morgan Chandler, Arnab Mukherjee, Neela H Yennawar, Squire J Booker, Kirill A Afonin, Nikolay V Dokholyan

Journal: ACS Appl Bio Mater

PubMed ID: 38700999

Doi: 10.1021/acsabm.4c00222

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Authors: Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi

Journal: Vaccines (Basel)

PubMed ID: 38793740

Doi: 10.3390/vaccines12050490

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Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

Authors: Facundo E Marmisolle, María B Borniego, Damián A Cambiagno, Lucia Gonzalo, María L García, Pablo A Manavella, Carmen Hernández, Carina A Reyes

Journal: Microbiol Spectr

PubMed ID: 38785434

Doi: 10.1128/spectrum.03513-23

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A fluorescence anisotropy-based competition assay to identify inhibitors against ricin and Shiga toxin ribosome interactions

Authors: Arkajyoti Dutta, Zoltan Szekely, Hakan Guven, Xiao-Ping Li, John E McLaughlin, Nilgun E Tumer

Journal: Anal Biochem

PubMed ID: 38825159

Doi: 10.1016/j.ab.2024.115580

Products & Services: Proteins, Expression, Isolation and Analysis

Multifunctional bispecific nanovesicles targeting SLAMF7 trigger potent antitumor immunity

Authors: Manman Zhu, Yongjian Wu, Tianchuan Zhu, Jian Chen, Zhenxing Chen, Hanxi Ding, Siyi Tan, Jianzhong He, Qi Zeng, Xi Huang

Journal: Cancer Immunol Res

PubMed ID: 38819238

Doi: 10.1158/2326-6066.CIR-23-1102

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Anti-HIV Humoral Response Induced by Different Anti-Idiotype Antibody Formats: An In Silico and In Vivo Approach

Authors: Valeria Caputo, Ilaria Negri, Louiza Moudoud, Martina Libera, Luigi Bonizzi, Massimo Clementi, Roberta Antonia Diotti

Journal: Int J Mol Sci

PubMed ID: 38891926

Doi: 10.3390/ijms25115737

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Cross-reactivity of hantavirus antibodies after immunization with PUUV antigens

Authors: Layaly Shkair, Diksha Sharma, Shaimaa Hamza, Ekaterina Garanina, Venara Shakirova, Ilsiyar Khaertynova, Maria Markelova, Vera Pavelkina, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal, Ekaterina Martynova

Journal: Biotechnol Appl Biochem

PubMed ID: 38779849

Doi: 10.1002/bab.2604

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Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B from : Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis

Authors: Corine O Smith, Graham R Moran

Journal: Biochemistry

PubMed ID: 38691339

Doi: 10.1021/acs.biochem.4c00025

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Radiation-primed TGF-β trapping by engineered extracellular vesicles for targeted glioblastoma therapy

Authors: Ruyu Liang, Hongyu Lu, Haifeng Zhu, Gaofeng Liang, Junxia Zhang, Jun Gao, Tian Tian

Journal: J Control Release

PubMed ID: 38740092

Doi: 10.1016/j.jconrel.2024.05.022

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