• 描述
  Claudins are a family of proteins, which play a role in maintaining tight cell junctions. Differentclaudin subtypes are expressed on different tissues.Claudin 18 isoform 2 (CLDN18.2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However, CLDN 18.2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101). It has also been shown to be expressed in a number of other cancers,including pancreatic (50%), esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, asevidenced by efforts to target CLDN18.2 via naked antibody and CAR-T modalities.
• 图片:
  

  [4 Images]

• 抗原物种:
  Human
• 表达系统:
  293 Cells
• 蛋白结构:

  CLDN18.2 (Met1-Val261 Full length) Accession # P56856-2	hFc
  N-term	C-term

• 同义词:
  Claudin-18.2; Claudin 18.2; CLDN18; Claudin-18
• 图片:
  

  [2 Images]

1 Citations

• 抗原物种:
  Human
• 表达系统:
  Insect Cells
• 蛋白结构:

  Poly-His	CLDN18.2 (Met1-Lys207) Accession # P56856-2
  N-term	C-term

• 同义词:
  Claudin-18; CLDN18; SFTA5; SFTPJ; claudin 18
• 图片:
  

  [2 Images]

• 描述
  Claudins are a family of proteins, which play a role in maintaining tight cell junctions. Differentclaudin subtypes are expressed on different tissues.Claudin18 isoform 2 (CLDN18.2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However, CLDN 18.2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101). It has also beenshown to be expressed in a number of other cancers,including pancreatic (50%), esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, asevidenced by effortsto target CLDN18.2 via naked antibody and CAR-T modalities.
• 图片:
  

  [2 Images]