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A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice

Authors: Xianmiao Ye, Xinglong Liu, Tao Shu, Weiqi Deng, Min Liao, Yali Zheng, Xuehua Zheng, Xiaoyan Zhang, Ting Li, Wenxia Fan, Linbing Qu, Ling Chen, Feng Li, Liqiang Feng

Journal: J Virol.

PubMed ID: 33910950

Doi: 10.1128/JVI.00383-21

Products & Services: Peptide Synthesis

Evaluation of Benzylpenicillin as an Internal Standard for Measurement of Piperacillin Bone Concentrations via Microdialysis

Authors: Martin Bruun Knudsen, Mats Bue, Louise L Pontoppidan, Magnus A Hvistendahl, Kjeld S?balle, Maiken Stilling, Pelle Hanberg

Journal: J Pharm Sci

PubMed ID: 34102200

Doi: 10.1016/j.xphs.2021.06.008

Products & Services: Mammalian Expression

Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9

Authors: Zhiquan Liu, Siyu Chen, Wanhua xie, Yuning Song, Jinze Li, Liangxue Lai, Zhanjun Li

Journal: Molecular Therapy

Doi: doi.org/10.1016/j.ymthe.2021.06.013

Products & Services: Gene Synthesis

Structural basis of substrate recognition and translocation by human ABCA4

Authors: Tian Xie， Zike Zhang, Qi Fang, Bowen Du& Xin Gong

Journal: Nature Communications

PubMed ID: 34158497

Doi: doi.org/10.1038/s41467-021-24194-6

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LncRSPH9-4 Facilitates Meningitic Escherichia coli-Caused Blood-Brain Barrier Disruption via miR-17-5p/MMP3 Axis

Authors: Bojie Xu , Ruicheng Yang, Jiyang Fu, Bo Yang, Jiaqi Chen , Chen Tan, Huanchun Chen and Xiangru Wang

Journal: International Journal of Molecular Sciences

PubMed ID: 34198485

Doi: 10.3390/ijms22126343

Products & Services: Gene Services

Peptides affecting outer membrane lipid asymmetry (MlaA-OmpC/F) system reduce avian pathogenic (APEC) colonization in chickens

Authors: Dipak Kathayat, Gary Closs, Yosra A Helmy, Dhanashree Lokesh, Sochina Ranjit, Gireesh Rajashekara

Journal: Appl Environ Microbiol

PubMed ID: 34132592

Doi: 10.1128/AEM.00567-21

Products & Services: Peptide Synthesis

Metformin-Inducible Small Heterodimer Partner Interacting Leucine Zipper Protein Ameliorates Intestinal Inflammation

Authors: SeungCheon Yang, Jin-Sil Park, Sun-Hee Hwang, Keun-Hyung Cho, Hyun Sik Na, JeongWon Choi, Jooyeon Jhun, Seung-Jun Kim, Bo-In Lee, Sung-Hwan Park, Mi-La Cho

Journal: Front Immunol

PubMed ID: 34211461

Doi: 10.3389/fimmu.2021.652709

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Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/β-catenin signaling pathway

Authors: Yan Hu, Hanshuo Mu, Ying Yang

Journal: Histol Histopathol

PubMed ID: 34100557

Doi: 10.14670/HH-18-349

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LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis

Authors: Lixia Yang, Liangyan Pei, Jilong Yi

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34188473

Doi: 10.2147/NDT.S309467

Products & Services: Gene Synthesis

Humoral and cellular immune responses against SARS-CoV-2 variants and human coronaviruses after single BNT162b2 vaccination

Authors: Metodi V Stankov, Anne Cossmann, Agnes Bonifacius, Alexandra Dopfer-Jablonka, Gema Morillas Ramos, Nina Gödecke, Anna Zychlinsky Scharff, Christine Happle, Anna-Lena Boeck, Anh Thu Tran, Isabell Pink, Marius M Hoeper, Rainer Blasczyk, Martin S Winkler, Inga Nehlmeier, Amy Kempf, Heike Hofmann-Winkler, Markus Hoffmann, Britta Eiz-Vesper, Stefan Pöhlmann, Georg M N Behrens

Journal: Clin Infect Dis

PubMed ID: 34134134

Doi: 10.1093/cid/ciab555

Products & Services: Proteins, Expression, Isolation and Analysis

Dissecting Out the Molecular Mechanism of Insecticidal Activity of Ostreolysin A6/Pleurotolysin B Complexes on Western Corn Rootworm

Authors: Matej Milijaš Jotić, Anastasija Panevska, Ioan Iacovache, Rok Kostanjšek, Martina Mravinec, Matej Skočaj, Benoît Zuber, Ana Pavšič, Jaka Razinger, Špela Modic, Francesco Trenti, Graziano Guella, Kristina Sepčić

Journal: Toxins (Basel)

PubMed ID: 34209983

Doi: 10.3390/toxins13070455

Products & Services: Plasmid DNA Preparation

The local anesthetic ropivacaine suppresses progression of breast cancer by regulating miR-27b-3p/YAP axis

Authors: Lu Zhao, Shuang Han, Junde Hou, Wenhui Shi, Yonglei Zhao, Yongxue Chen

Journal: Aging (Albany NY)

PubMed ID: 34126594

Doi: 10.18632/aging.203160

Products & Services: Plasmid DNA Preparation

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation

Authors: Sandra Torres, Estel Solsona-Vilarrasa, Susana Nuñez, Nuria Matías, Naroa Insausti-Urkia, Fernanda Castro, Mireia Casasempere, Gemma Fabriás, Josefina Casas, Carlos Enrich, José C Fernández-Checa, Carmen Garcia-Ruiz

Journal: Redox Biol

PubMed ID: 34175669

Doi: 10.1016/j.redox.2021.102052

Products & Services: Plasmid DNA Preparation

Allelic diversification after transposable element exaptation promoted as the master sex determining gene of sablefish

Authors: Amaury Herpin, Manfred Schartl, Alexandra Depincé, Yann Guiguen, Julien Bobe, Aurélie Hua-Van, Edward S Hayman, Anna Octavera, Goro Yoshizaki, Krista M Nichols, Giles W Goetz, J Adam Luckenbach

Journal: Genome Res

PubMed ID: 34183453

Doi: 10.1101/gr.274266.120

Products & Services: PCR Cloning and Subcloning

Self-assembled small messenger RNA nanospheres for efficient therapeutic apoptin expression and synergistic Gene-Chemotherapy of breast cancer

Authors: Yuxia Tang, Xiang Liao, Chunyan Wang, Ying Liu, Jing Pan, Ying Tian, Zhaogang Teng, Guangming Lu

Journal: J Colloid Interface Sci

PubMed ID: 34192626

Doi: 10.1016/j.jcis.2021.06.061

Products & Services: PCR Cloning and Subcloning

MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3

Authors: Wei Jin, Yilei Liang, Shuyou Li, Guoxiang Lin, Haiying Liang, Zhenni Zhang, Weiming Zhang, Rongjun Nie

Journal: Aging (Albany NY)

PubMed ID: 34120890

Doi: 10.18632/aging.203135

Products & Services: Molecular Biology Reagents

Mulberroside A repairs high fructose diet-induced damage of intestinal epithelial and blood-brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

Authors: Yu R,Wen S,Wang Q,Wang C,Zhang L,Wu X,Li J,Kong L

Journal: Journal of neurochemistry

PubMed ID: 33205422

Doi: 10.1111/jnc.15242

Products & Services: Endotoxin Detection & Removal System

Inherent backbone dynamics fine-tune the functional plasticity of Tudor domains

Authors: Ashish A Kawale, Björn M Burmann

Journal: Structure

PubMed ID: 34197736

Doi: 10.1016/j.str.2021.06.007

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Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

Authors: Chiara Brullo, Federica Rapetti, Sara Abbate, Tommaso Prosdocimi, Archimede Torretta, Marta Semrau, Matteo Massa, Silvana Alfei, Paola Storici, Emilio Parisini, Olga Bruno

Journal: Eur J Med Chem

PubMed ID: 34171658

Doi: 10.1016/j.ejmech.2021.113638

Products & Services: Codon Optimization

A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy

Authors: Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, Kenzo Ohara, Mizuho Ohara, Takumi Kumai, Kei Ishibashi, Yui Hirata-Nozaki, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Esteban Celis, Toshikatsu Okumura, Yoshinobu Ohsaki, Hiroya Kobayashi, Takayuki Ohkuri

Journal: Cancer Sci

PubMed ID: 34009705

Doi: 10.1111/cas.14973

Products & Services: Catalog Peptides

Pharmacokinetics, Immunogenicity and Safety Study for SHR-1309 Injection and Perjeta® in Healthy Chinese Male Volunteers

Authors: Yingzi Cui, Dongyang Cui, Xinran Ren, Xuesong Chen, Guangwen Liu, Zhengzhi Liu, Yanli Wang, Xinyao Qu, Yicheng Zhao, Haimiao Yang

Journal: Front Pharmacol

PubMed ID: 34149414

Doi: 10.3389/fphar.2021.660541

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Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing

Authors: Phuc Leo H Vo, Christopher Acree, Melissa L Smith, Samuel H Sternberg

Journal: Mob DNA

PubMed ID: 34103093

Doi: 10.1186/s13100-021-00242-2

Products & Services: Gene Synthesis

Cellulosome Localization Patterns Vary across Life Stages of Anaerobic Fungi

Authors: Stephen P Lillington, William Chrisler, Charles H Haitjema, Sean P Gilmore, Chuck R Smallwood, Vaithiyalingam Shutthanandan, James E Evans, Michelle A O'Malley

Journal: MBio

PubMed ID: 34061594

Doi: 10.1128/mBio.00832-21

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Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type

Authors: Donghui Shen, Fengna Chu, Yue Lang, Chao Zheng, Chunrong Li, Kangding Liu, Jie Zhu

Journal: Clin Exp Immunol

PubMed ID: 34118070

Doi: 10.1111/cei.13637

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Identification of testicular Foxq1 as a critical modulator of lactate metabolism in mouse Sertoli cells

Authors: Zetao Liu, Mingyou Yuan, Xiangxiang Meng, Haiwen Bie, Shaobo Yao

Journal: Histochem Cell Biol

PubMed ID: 34091745

Doi: 10.1007/s00418-021-01994-x

Products & Services: Gene Synthesis

Mummichog gill and operculum exhibit functionally consistent claudin-10 paralog profiles and Claudin-10c hypersaline response

Authors: Chun Chih Chen, William S Marshall, George N Robertson, Regina R F Cozzi, Scott P Kelly

Journal: Biol Open

PubMed ID: 34156063

Doi: 10.1242/bio.058868

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Multi-locus sequence typing analysis of Mycoplasma synoviae isolates reveals unique sequence types in China

Authors: Xiaorong Zhang, Yang Chen, Di Xie, Mengjiao Guo, Shuang Ma, Mengyao Chen, Dianfeng Chu, Yantao Wu

Journal: Vet Microbiol

PubMed ID: 34166888

Doi: 10.1016/j.vetmic.2021.109101

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The Rac-GAP alpha2-chimaerin signals via CRMP2 and stathmins in the development of the ocular motor system

Authors: Luis Carretero-Rodriguez, Ragnheiður Guðjónsdóttir, Ivana Poparic, Madeline Louise Reilly, Mary Chol, Isaac H Bianco, Marco Chiapello, Renata Feret, Michael J Deery, Sarah Guthrie

Journal: J Neurosci

PubMed ID: 34168008

Doi: 10.1523/JNEUROSCI.0983-19.2021

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Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

Authors: Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Niem-Redene, Szu-Yi Chou, Luc Buée, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf

Journal: Brain

PubMed ID: 34086871

Doi: 10.1093/brain/awab205

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MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT)

Authors: Baoyi Yang, Shitao Xia, Xiangmei Ye, Wei Jing, Beifeng Wu

Journal: Biochem Biophys Res Commun

PubMed ID: 34171541

Doi: 10.1016/j.bbrc.2021.05.099

Products & Services: Recombinant Proteins

Immune and experimental infection responses of dairy cows vaccinated with the combination of six Staphylococcus aureus proteins that are expressed during bovine intramammary infection and a triple adjuvant

Authors: Céline Ster, Marianne Allard, Julie Côté-Gravel, Simon Boulanger, Pierre Lacasse, François Malouin

Journal: Vet Immunol Immunopathol

PubMed ID: 34217108

Doi: 10.1016/j.vetimm.2021.110290

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Oral Delivery of Expressing Chicken NK-2 Peptide Protects Against Infection in Broiler Chickens

Authors: Samiru S Wickramasuriya, Inkyung Park, Youngsub Lee, Woo H Kim, Chris Przybyszewski, Cyril G Gay, Jolieke G van Oosterwijk, Hyun S Lillehoj

Journal: Front Vet Sci

PubMed ID: 34150899

Doi: 10.3389/fvets.2021.684818

Products & Services: Recombinant Proteins

Development and Validation of a Simoa Assay for Determination of Recombinant Batroxobin in Human Serum

Authors: Bian-Zhen Wang, Meng-Jia Wang, Min-Rui Wang, Lun Ou, Li-Hou Dong, Kelly Dong, Hai-Feng Song

Journal: Curr Med Sci

PubMed ID: 34169424

Doi: 10.1007/s11596-021-2382-6

Products & Services: Monoclonal Antibody Services

Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests

Authors: Carolina De Marco Verissimo, Carol O'Brien, Jesús López Corrales, Amber Dorey, Krystyna Cwiklinski, Richard Lalor, Jack M Doyle, Stephen Field, Claire Masterson, Eduardo Ribes Martinez, Gerry Hughes, Colm Bergin, Kieran Walshe, Bairbre McNicholas, John G Laffey, John P Dalton, Colm Kerr, Sean Doyle

Journal: Epidemiol Infect

PubMed ID: 34099081

Doi: 10.1017/S0950268821001308

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Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2

Authors: Joel Pinczewski, Rebecca C Obeng, Craig L Slingluff, Victor H Engelhard

Journal: Pathol Res Pract

PubMed ID: 34167064

Doi: 10.1016/j.prp.2021.153527

Products & Services: Peptide Synthesis

Synthetic conjugate peptide Fba-Met6 (MP12) induces complement-mediated resistance against disseminated Candida albicans

Authors: Abby L Adams, Karen Eberle, Jonothan Rosario Colón, Evan Courville, Hong Xin

Journal: Vaccine

PubMed ID: 34127293

Doi: 10.1016/j.vaccine.2021.06.001

Products & Services: Mammalian Expression

Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma

Authors: Sarah Müller, Stefanie Mayer, Peter Möller, Thomas F E Barth, Ralf Marienfeld

Journal: Neoplasia

PubMed ID: 34102454

Doi: 10.1016/j.neo.2021.05.005

Products & Services: Gene Synthesis

Identification and validation of T-cell receptors targeting RAS hot-spot mutations in human cancers for use in cell-based immunotherapy

Authors: Noam Levin, Biman C Paria, Nolan R Vale, Rami Yoseph, Frank J Lowery, Maria R Parkhurst, Zhiya Yu, Maria Florentin, Gal Cafri, Jared J Gartner, Mackenzie L Shindorf, Lien T Ngo, Satyajit Ray, Sanghyun P Kim, Amy R Copeland, Paul F Robbins, Steven A Rosenberg

Journal: Clin Cancer Res

PubMed ID: 34168045

Doi: 10.1158/1078-0432.CCR-21-0849

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Identification of a protein unique to the genus Plasmodium that contains a WD40 repeat domain and extensive low-complexity sequence

Authors: Gladys T Cortés, Martha Margarita Gonzalez Beltran, Claudio J Gómez-Alegría, Mark F Wiser

Journal: Parasitol Res

PubMed ID: 34142223

Doi: 10.1007/s00436-021-07190-z

Products & Services: DNA Sequencing

CyDisCo production of functional recombinant SARS-CoV-2 spike receptor binding domain

Authors: Janani Prahlad, Lucas R Struble, William E Lutz, Savanna A Wallin, Surender Khurana, Andy Schnaubelt, Mara J Broadhurst, Kenneth W Bayles, Gloria E O Borgstahl

Journal: Protein Sci

PubMed ID: 34191362

Doi: 10.1002/pro.4152

Products & Services: Nucleic Acid Purification & Analysis

mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer

Authors: Ling Tian, Congcong Chen, Yanguan Guo, Fan Zhang, Jinye Mi, Qi Feng, Shengbin Lin, Naite Xi, Jiaxin Tian, Li Yu, Yan Chen, Mingrong Cao, Caiyong Lai, Jun Fan, Yongchang Zhang, Guo Chen

Journal: Neoplasia

PubMed ID: 34126361

Doi: 10.1016/j.neo.2021.05.007

Products & Services: Plasmid DNA Preparation

An updated RT-qPCR assay for the simultaneous detection and quantification of chikungunya, dengue and zika viruses

Authors: Diego Alejandro Álvarez-Díaz, Emmanuel Valencia-Álvarez, Jorge Alonso Rivera, Aura Caterine Rengifo, José Aldemar Usme-Ciro, Dioselina Peláez-Carvajal, Yenny Yolanda Lozano-Jiménez, Orlando Torres-Fernández

Journal: Infect Genet Evol

PubMed ID: 34116240

Doi: 10.1016/j.meegid.2021.104967

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Novel neuroprotective peptides in the venom of the solitary scoliid wasp

Authors: Carlos Alberto-Silva, Fernanda Calheta Vieira Portaro, Roberto Tadashi Kodama, Halyne Queiroz Pantaleão, Marisa Rangel, Ken-Ichi Nihei, Katsuhiro Konno

Journal: J Venom Anim Toxins Incl Trop Dis

PubMed ID: 34194483

Doi: 10.1590/1678-9199-JVATITD-2020-0171

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Improvement in extracellular secretion of recombinant L-asparaginase II by Escherichia coli BL21 (DE3) using glycine and n-dodecane

Authors: Juan Carlos Flores-Santos, Ignacio S Moguel, Gisele Monteiro, Adalberto Pessoa, Michele Vitolo

Journal: Braz J Microbiol

PubMed ID: 34100260

Doi: 10.1007/s42770-021-00534-y

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H, C, N backbone and side-chain NMR assignments of the C-terminal domain of Mycobacterium Tuberculosis ribosome maturation factor RimM

Authors: Haoran Zhang, Chenyun Guo, Donghai Lin

Journal: Biomol NMR Assign

PubMed ID: 34101143

Doi: 10.1007/s12104-021-10032-9

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Structural and biochemical characterization of a novel ZntB (CmaX) transporter protein from Pseudomonas aeruginosa

Authors: Artem Stetsenko, Pavlo Stehantsev, Natalia O Dranenko, Mikhail S Gelfand, Albert Guskov

Journal: Int J Biol Macromol

PubMed ID: 34175341

Doi: 10.1016/j.ijbiomac.2021.06.130

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Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis

Authors: Zhongfang Zhao, Nong Liao

Journal: Onco Targets Ther

PubMed ID: 34168462

Doi: 10.2147/OTT.S275322

Products & Services: Gene Synthesis

SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods

Authors: Elitza S Theel, Patrick W Johnson, Katie L Kunze, Liang Wu, Amy P Gorsh, Dane Granger, Matthew M Roforth, Calvin R Jerde, Michael Lasho, Kylie J Andersen, Brenna M Murphy, Julie Harring, Douglas F Lake, Sergei A Svarovsky, Jonathon W Senefeld, Rickey E Carter, Michael J Joyner, Nikola A Baumann, John R Mills

Journal: J Clin Microbiol

PubMed ID: 34166066

Doi: 10.1128/JCM.01231-21

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Phage vB_PaeS-PAJD-1 Rescues Murine Mastitis Infected With Multidrug-Resistant

Authors: Zhaofei Wang, Yibing Xue, Ya Gao, Mengting Guo, Yuanping Liu, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan

Journal: Front Cell Infect Microbiol

PubMed ID: 34178726

Doi: 10.3389/fcimb.2021.689770

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Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer

Authors: Claudia Enriquez, Valeria Cancila, Renata Ferri, Roberta Sulsenti, Irene Fischetti, Matteo Milani, Paola Ostano, Ilaria Gregnanin, Maurizia Mello-Grand, Enrico Berrino, Marco Bregni, Giuseppe Renne, Claudio Tripodo, Mario P Colombo, Elena Jachetti

Journal: Cancer Res

PubMed ID: 34185677

Doi: 10.1158/0008-5472.CAN-21-0163

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Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Invasive Infection

Authors: Jonothan Rosario-Colon, Karen Eberle, Abby Adams, Evan Courville, Hong Xin

Journal: Int J Mol Sci

PubMed ID: 34200478

Doi: 10.3390/ijms22116162

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Distinct responses of human peripheral blood cells to different misfolded protein oligomers

Authors: Magdalena Leal-Lasarte, Benedetta Mannini, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson, Cintia Roodveldt, David Pozo

Journal: Immunology

PubMed ID: 34043816

Doi: 10.1111/imm.13377

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Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib

Authors: Eric J Niesor, Guy Boivin, Eric Rhéaume, Rong Shi, Véronique Lavoie, Nathalie Goyette, Marie-Eve Picard, Anne Perez, Fouzia Laghrissi-Thode, Jean-Claude Tardif

Journal: ACS Omega

PubMed ID: 34235330

Doi: 10.1021/acsomega.1c01797

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of an Atypical Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

Authors: Adélle Burger, Paula Macucule-Tinga, Stephen John Bentley, Michael Hans Ludewig, Ndumiso Nhlakanipho Mhlongo, Addmore Shonhai, Aileen Boshoff

Journal: Int J Mol Sci

PubMed ID: 34202520

Doi: 10.3390/ijms22136776

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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Authors: Taylor R Jamieson, Joanna Poutou, Ricardo Marius, Xiaohong He, Reza Rezaei, Taha Azad, Carolina S Ilkow

Journal: J Vis Exp

PubMed ID: 34152313

Doi: 10.3791/62486

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Mini-Replicon-Based Reverse-Genetics System for Rice Stripe Tenuivirus

Authors: Mingfeng Feng, Luyao Li, Ruixiang Cheng, Yulong Yuan, Yongxin Dong, Minglong Chen, Rong Guo, Min Yao, Yi Xu, Yijun Zhou, Jianxiang Wu, Xin Shun Ding, Xueping Zhou, Xiaorong Tao

Journal: J Virol

PubMed ID: 33952642

Doi: 10.1128/JVI.00589-21

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Identification of a dual orange/far-red and blue light photoreceptor from an oceanic green picoplankton

Authors: Yuko Makita, Shigekatsu Suzuki, Keiji Fushimi, Setsuko Shimada, Aya Suehisa, Manami Hirata, Tomoko Kuriyama, Yukio Kurihara, Hidefumi Hamasaki, Emiko Okubo-Kurihara, Kazutoshi Yoshitake, Tsuyoshi Watanabe, Masaaki Sakuta, Takashi Gojobori, Tomoko Sakami, Rei Narikawa, Haruyo Yamaguchi, Masanobu Kawachi, Minami Matsui

Journal: Nat Commun

PubMed ID: 34135337

Doi: 10.1038/s41467-021-23741-5

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miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3

Authors: Fengzhen Liu, Xia Zhang, You Peng, Liping Zhang, Yao Yu, Peng Hua, Peiying Zhu, Xinyu Yan, Yin Li, Liang Zhang

Journal: Cell Rep

PubMed ID: 34107258

Doi: 10.1016/j.celrep.2021.109225

Products & Services: ORF cDNA Clones/MolecularCloud

HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency

Authors: Helin Sertkaya, Mattia Ficarelli, Nathan P Sweeney, Hannah Parker, Conrad A Vink, Chad M Swanson

Journal: Sci Rep

PubMed ID: 34103612

Doi: 10.1038/s41598-021-91309-w

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Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

Authors: Sangsu Park, Minh Quan Nguyen, Huynh Kim Khanh Ta, Minh Tan Nguyen, Gunsup Lee, Chong Jai Kim, Yeon Jin Jang, Han Choe

Journal: Int J Mol Sci

PubMed ID: 34204265

Doi: 10.3390/ijms22126483

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Novel Bacterial Production of Two Different Bioactive Forms of Human Stem-Cell Factor

Authors: Eunyoung Lee, Michelle Novais de Paula, Sangki Baek, Huynh Kim Khanh Ta, Minh Tan Nguyen, Taeck-Hyun Jeong, Chong Jai Kim, Yeon Jin Jang, Han Choe

Journal: Int J Mol Sci

PubMed ID: 34198626

Doi: 10.3390/ijms22126361

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The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer

Authors: Katie A Thies, Matthew W Cole, Rachel E Schafer, Jonathan M Spehar, Dillon S Richardson, Sarah A Steck, Manjusri Das, Arthur W Lian, Alo Ray, Reena Shakya, Sue E Knoblaugh, Cynthia D Timmers, Michael C Ostrowski, Arnab Chakravarti, Gina M Sizemore, Steven T Sizemore

Journal: Breast Cancer Res

PubMed ID: 34118960

Doi: 10.1186/s13058-021-01438-3

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A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription

Authors: Juston C Weems, Brian D Slaughter, Jay R Unruh, Kyle J Weaver, Brandon D Miller, Kym M Delventhal, Joan W Conaway, Ronald C Conaway

Journal: J Biol Chem

PubMed ID: 34116057

Doi: 10.1016/j.jbc.2021.100862

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Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Authors: Maura Garofalo, Luca Piccoli, Margherita Romeo, Maria Monica Barzago, Sara Ravasio, Mathilde Foglierini, Milos Matkovic, Jacopo Sgrignani, Raoul De Gasparo, Marco Prunotto, Luca Varani, Luisa Diomede, Olivier Michielin, Antonio Lanzavecchia, Andrea Cavalli

Journal: Nat Commun

PubMed ID: 34112780

Doi: 10.1038/s41467-021-23880-9

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Prdx1 Interacts with ASK1 upon Exposure to HO and Independently of a Scaffolding Protein

Authors: Trung Nghia Vo, Julia Malo Pueyo, Khadija Wahni, Daria Ezeriņa, Jesalyn Bolduc, Joris Messens

Journal: Antioxidants (Basel)

PubMed ID: 34209102

Doi: 10.3390/antiox10071060

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Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1

Authors: Jin Chai, Yuanheng Cai, Changxu Pang, Liguo Wang, Sean McSweeney, John Shanklin, Qun Liu

Journal: Nat Commun

PubMed ID: 34103506

Doi: 10.1038/s41467-021-23533-x

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Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D

Authors: Youchao Deng, Sunbin Deng, Yi-Hsun Ho, Sarah M Gardner, Zhi Huang, Ronen Marmorstein, Rong Huang

Journal: J Med Chem

PubMed ID: 34110812

Doi: 10.1021/acs.jmedchem.1c00141

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The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status

Authors: Patricia Garcia-Garcia, Ricardo Reyes, José Antonio Rodriguez, Tomas Martín, Carmen Evora, Patricia Díaz-Rodríguez, Araceli Delgado

Journal: Pharmaceutics

PubMed ID: 34209593

Doi: 10.3390/pharmaceutics13070979

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CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression

Authors: Yi Liu, Simin Chen, Gang Peng, Yiwei Liao, Xuegong Fan, Zuping Zhang, Chenfu Shen

Journal: Cancer Cell Int

PubMed ID: 34112159

Doi: 10.1186/s12935-021-02001-y

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ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion

Authors: Qiangmin Zhang, Julia Gefter, W Bruce Sneddon, Tatyana Mamonova, Peter A Friedman

Journal: iScience

PubMed ID: 34189428

Doi: 10.1016/j.isci.2021.102770

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A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge

Authors: Zachary R Sia, Xuedan He, Ali Zhang, Jann C Ang, Shuai Shao, Amal Seffouh, Wei-Chiao Huang, Michael R D'Agostino, Amir Teimouri Dereshgi, Sambhara Suryaprakash, Joaquin Ortega, Hanne Andersen, Matthew S Miller, Bruce A Davidson, Jonathan F Lovell

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34050027

Doi: 10.1073/pnas.2025759118

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Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence

Authors: Kirsi Savijoki, Henna Myllymäki, Hanna Luukinen, Lauri Paulamäki, Leena-Maija Vanha-Aho, Aleksandra Svorjova, Ilkka Miettinen, Adyary Fallarero, Teemu O Ihalainen, Jari Yli-Kauhaluoma, Tuula A Nyman, Mataleena Parikka

Journal: mSystems

PubMed ID: 34156290

Doi: 10.1128/mSystems.00500-21

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LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p

Authors: Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma, Xin Gao

Journal: BMC Cancer

PubMed ID: 34078310

Doi: 10.1186/s12885-021-08227-3

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Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins

Authors: Eriko Ohgitani, Masaharu Shin-Ya, Masaki Ichitani, Makoto Kobayashi, Takanobu Takihara, Masaya Kawamoto, Hitoshi Kinugasa, Osam Mazda

Journal: Molecules

PubMed ID: 34208050

Doi: 10.3390/molecules26123572

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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

Authors: Ebony N Gary, Bryce M Warner, Elizabeth M Parzych, Bryan D Griffin, Xizhou Zhu, Nikesh Tailor, Nicholas J Tursi, Mable Chan, Mansi Purwar, Robert Vendramelli, Jihae Choi, Kathy L Frost, Sophia Reeder, Kevin Liaw, Edgar Tello, Ali R Ali, Kun Yun, Yanlong Pei, Sylvia P Thomas, Amira D Rghei, Matthew M Guilleman, Kar Muthumani, Trevor Smith, Sarah K Wootton, Ami Patel, David B Weiner, Darwyn Kobasa

Journal: iScience

PubMed ID: 34124612

Doi: 10.1016/j.isci.2021.102699

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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Authors: Yiwen Zhang, Yingshi Chen, Yuzhuang Li, Feng Huang, Baohong Luo, Yaochang Yuan, Baijin Xia, Xiancai Ma, Tao Yang, Fei Yu, Jun Liu, Bingfeng Liu, Zheng Song, Jingliang Chen, Shumei Yan, Liyang Wu, Ting Pan, Xu Zhang, Rong Li, Wenjing Huang, Xin He, Fei Xiao, Junsong Zhang, Hui Zhang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34021074

Doi: 10.1073/pnas.2024202118

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Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers

Authors: Daiki Kashima, Masahiro Kawahara

Journal: Sci Rep

PubMed ID: 34083659

Doi: 10.1038/s41598-021-91287-z

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Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells

Authors: Ruoxi W Wang, Sonia Viganò, Uri Ben-David, Angelika Amon, Stefano Santaguida

Journal: EMBO Rep

PubMed ID: 34105235

Doi: 10.15252/embr.202052032

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The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA

Authors: Olga A Postnikova, Sheetal Uppal, Weiliang Huang, Maureen A Kane, Rafael Villasmil, Igor B Rogozin, Eugenia Poliakov, T Michael Redmond

Journal: Int J Mol Sci

PubMed ID: 34204305

Doi: 10.3390/ijms22126490

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Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

Authors: Claudia Vivori, Panagiotis Papasaikas, Ralph Stadhouders, Bruno Di Stefano, Anna Ribó Rubio, Clara Berenguer Balaguer, Serena Generoso, Anna Mallol, José Luis Sardina, Bernhard Payer, Thomas Graf, Juan Valcárcel

Journal: Genome Biol

PubMed ID: 34082786

Doi: 10.1186/s13059-021-02372-5

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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Authors: Maritza Puray-Chavez, Kyle M LaPak, Travis P Schrank, Jennifer L Elliott, Dhaval P Bhatt, Megan J Agajanian, Ria Jasuja, Dana Q Lawson, Keanu Davis, Paul W Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E Eschbach, Christian Shema Mugisha, Emily M Cousins, Erica W Cloer, Hung R Vuong, Laura A VanBlargan, Adam L Bailey, Pavlo Gilchuk, James E Crowe, Michael S Diamond, D Neil Hayes, Sean P J Whelan, Amjad Horani, Steven L Brody, Dennis Goldfarb, M Ben Major, Sebla B Kutluay

Journal: Cell Rep

PubMed ID: 34214467

Doi: 10.1016/j.celrep.2021.109364

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Effective Killing of Acute Myeloid Leukemia by TIM-3 Targeted Chimeric Antigen Receptor T Cells

Authors: Wen-Hsin Sandy Lee, Zhiyong Ye, Alice M S Cheung, Y P Sharon Goh, Hsueh Ling Janice Oh, Ravisankar Rajarethinam, Siok Ping Yeo, Mun Kuen Soh, Esther Hian Li Chan, Lip Kun Tan, Soo-Yong Tan, Charles Chuah, Wee Joo Chng, John E Connolly, Cheng-I Wang

Journal: Mol Cancer Ther

PubMed ID: 34158344

Doi: 10.1158/1535-7163.MCT-20-0155

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Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol

Authors: Sarah Mazzotta, Judith Berastegui-Cabrera, Margarita Vega-Holm, María Del Rosario García-Lozano, Marta Carretero-Ledesma, Francesca Aiello, José Manuel Vega-Pérez, Jerónimo Pachón, Fernando Iglesias-Guerra, Javier Sánchez-Céspedes

Journal: Bioorg Chem

PubMed ID: 34175724

Doi: 10.1016/j.bioorg.2021.105095

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In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

Authors: Daniel Pokorny, Linda Truebestein, Kaelin D Fleming, John E Burke, Thomas A Leonard

Journal: J Biol Chem

PubMed ID: 34181950

Doi: 10.1016/j.jbc.2021.100919

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A phase transition enhances the catalytic activity of SARM1, an NAD glycohydrolase involved in neurodegeneration

Authors: Heather S Loring, Victoria L Czech, Janneke D Icso, Lauren O'Connor, Sangram S Parelkar, Alexandra B Byrne, Paul R Thompson

Journal: Elife

PubMed ID: 34184985

Doi: 10.7554/eLife.66694

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Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Authors: Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Parant

Journal: Cell Death Dis

PubMed ID: 34193827

Doi: 10.1038/s41419-021-03902-6

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Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

Authors: Matthieu P M H Benoit, Ana B Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H Kwok, Hernando Sosa

Journal: Nat Commun

PubMed ID: 34131133

Doi: 10.1038/s41467-021-23581-3

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Assembly principles and stoichiometry of a complete human kinetochore module

Authors: Kai Walstein, Arsen Petrovic, Dongqing Pan, Birte Hagemeier, Dorothee Vogt, Ingrid R Vetter, Andrea Musacchio

Journal: Sci Adv

PubMed ID: 34193424

Doi: 10.1126/sciadv.abg1037

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Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

Authors: Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F B Räder, William J Polacheck, Horst Kessler, Lydia Sorokin, Britta Trappmann

Journal: Nat Commun

PubMed ID: 34099677

Doi: 10.1038/s41467-021-23644-5

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Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota

Authors: Djalma S Lima-Junior, Siddharth R Krishnamurthy, Nicolas Bouladoux, Nicholas Collins, Seong-Ji Han, Erin Y Chen, Michael G Constantinides, Verena M Link, Ai Ing Lim, Michel Enamorado, Christophe Cataisson, Louis Gil, Indira Rao, Taylor K Farley, Galina Koroleva, Jan Attig, Stuart H Yuspa, Michael A Fischbach, George Kassiotis, Yasmine Belkaid

Journal: Cell

PubMed ID: 34166614

Doi: 10.1016/j.cell.2021.05.020

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Directed evolution of AAV accounting for long-term and enhanced transduction of cardiovascular endothelial cells

Authors: Y B Liu, B C Xu, Y T Chen, X Yuan, J Y Liu, T Liu, G Z Du, W Jiang, Y Yang, Y Zhu, L J Chen, B S Ding, Y Q Wei, L Yang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34485601

Doi: 10.1016/j.omtm.2021.05.015

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A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

Authors: Alexandra Tauzin, Manon Nayrac, Mehdi Benlarbi, Shang Yu Gong, Romain Gasser, Guillaume Beaudoin-Bussières, Nathalie Brassard, Annemarie Laumaea, Dani Vézina, Jérémie Prévost, Sai Priya Anand, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Guillaume Goyette, Julia Niessl, Olivier Tastet, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Leonidas Stamatatos, Andrew T McGuire, Catherine Larochelle, Pradeep Uchil, Maolin Lu, Walther Mothes, Gaston De Serres, Sandrine Moreira, Michel Roger, Jonathan Richard, Valérie Martel-Laferrière, Ralf Duerr, Cécile Tremblay, Daniel E Kaufmann, Andrés Finzi

Journal: Cell Host Microbe

PubMed ID: 34133950

Doi: 10.1016/j.chom.2021.06.001

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Absolute protein assay for the simultaneous quantification of two epoxide hydrolases in rats by mass spectrometry-based targeted proteomics

Authors: Ting Wu, Xiaoyun Xi, Ying Chen, Chao Jiang, Qian Zhang, Guoliang Dai, Yongtao Bai, Weidong Zhang, Ting Ni, Jiandong Zou, Wenzheng Ju, Meijuan Xu

Journal: J Sep Sci

PubMed ID: 34008891

Doi: 10.1002/jssc.202100066

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Sphingomonas sp. KT‑1 PahZ2 Structure Reveals a Role for Conformational Dynamics in Peptide Bond Hydrolysis

Authors: Chad A. BrambleyChad A. Brambley Department of Chemistry, Middle Tennessee State University, 1301 East Main Street, Murfreesboro, Tennessee 37132, United States More by Chad A. Brambley , Tarah J. Yared, Marriah Gonzalez, Amanda L. Jansch, Jamie R. Wallen, Mitch H. Weiland*, and Justin M. Miller*

Journal: The Journal of Physical Chemistry B

PubMed ID: 34060838

Doi: doi.org/10.1021/acs.jpcb.1c01216

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Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs

Authors: Stepan S. Denisov, Johannes H. Ippel, Elisabetta Castoldi, Ben J. Mans, Tilman M. Hackeng, and Ingrid Dijkgraaf

Journal: Journal of Biological Chemistry

PubMed ID: 34118237

Doi: 10.1016/j.jbc.2021.100865

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Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

Authors: Xuerui Zhang, Lulu Song, Lin Li, Banghui Zhu, Lina Huo, Zhaoqing Hu, Xinran Wang, Jie Wang, Mengyue Gao, Jing Zhang and Zichun Hua