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至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

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Exendin-4 Pretreatment Attenuates Kainic Acid-Induced Hippocampal Neuronal Death

Authors: Yu-Jeong Ahn, Hyun-Joo Shin, Eun-Ae Jeong, Hyeong-Seok An, Jong-Youl Lee, Hye-Min Jang, Kyung-Eun Kim, Jaewoong Lee, Meong-Cheol Shin, Gu-Seob Roh

Journal: Cells

PubMed ID: 34685508

Doi: 10.3390/cells10102527

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Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations

Authors: Catarina Pimpão, Darren Wragg, Riccardo Bonsignore, Brech Aikman, Per Amstrup Pedersen, Stefano Leoni, Graça Soveral, Angela Casini

Journal: Metallomics

PubMed ID: 34468767

Doi: 10.1093/mtomcs/mfab053

Products & Services: Codon Optimization

Structure of the human marker of self 5-transmembrane receptor CD47

Authors: Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y-C Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P Chamberlain, Ho Cho, Kandasamy Hariharan

Journal: Nat Commun

PubMed ID: 34471125

Doi: 10.1038/s41467-021-25475-w

Products & Services: Codon Optimization

Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity

Authors: Victor A Prieto, Kevin E W Namitz, Scott A Showalter

Journal: J Phys Chem B

PubMed ID: 34550709

Doi: 10.1021/acs.jpcb.1c05131

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Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice

Authors: Thuntawat Aunguldee, Orapin Gerdprasert, Piyatida Tangteerawatana, Amporn Jariyapongskul, Saovanee Leelayoova, Benjamas Thanomsub Wongsatayanon

Journal: J Infect Dev Ctries

PubMed ID: 34669604

Doi: 10.3855/jidc.14472

Products & Services: Gene Synthesis

Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance

Authors: Chitavi D Maulloo, Shijie Cao, Elyse A Watkins, Michal M Raczy, Ani S Solanki, Mindy Nguyen, Joseph W Reda, Ha-Na Shim, D Scott Wilson, Melody A Swartz, Jeffrey A Hubbell

Journal: Front Immunol

PubMed ID: 34630389

Doi: 10.3389/fimmu.2021.714842

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Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

Authors: Zhen Wei, Yongxue Xu, Qing Xu, Wei Cao, He Huang, Hao Liu

Journal: Front Bioeng Biotechnol

PubMed ID: 34660563

Doi: 10.3389/fbioe.2021.765685

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The Isolated in Utero Environment Is Conducive to the Emergence of RNA and DNA Virus Variants

Authors: Daniel Udenze, Ivan Trus, Henry Munyanduki, Nathalie Berube, Uladzimir Karniychuk

Journal: Viruses

PubMed ID: 34578408

Doi: 10.3390/v13091827

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Antibody signatures of asymptomatic Plasmodium falciparum malaria infections measured from dried blood spots

Authors: Christine F Markwalter, Myat Htut Nyunt, Zay Yar Han, Ricardo Henao, Aarti Jain, Omid Taghavian, Philip L Felgner, Kay Thwe Han, Myaing M Nyunt, Christopher V Plowe

Journal: Malar J

PubMed ID: 34556121

Doi: 10.1186/s12936-021-03915-8

Products & Services: Bacterial Expression

SARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function

Authors: Fabian Brunk, Andreas Moritz, Annika Nelde, Tatjana Bilich, Nicolas Casadei, Sabine A K Fraschka, Jonas S Heitmann, Sebastian Hörber, Andreas Peter, Hans-Georg Rammensee, Harpreet Singh, Juliane Walz, Dominik Maurer, Claudia Wagner

Journal: Eur J Immunol

PubMed ID: 34424997

Doi: 10.1002/eji.202149290

Products & Services: Gene Synthesis

APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

Authors: Daniel Constantin, Gilles Dubuis, María Del Carmen Conde-Rubio, Christian Widmann

Journal: FEBS J

PubMed ID: 34528388

Doi: 10.1111/febs.16202

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Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

Authors: Mona Teppor, Eva Žusinaite, Liis Karo-Astover, Ailar Omler, Kai Rausalu, Valeria Lulla, Aleksei Lulla, Andres Merits

Journal: J Virol

PubMed ID: 34319778

Doi: 10.1128/JVI.00973-21

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DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Authors: Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34568799

Doi: 10.1016/j.isci.2021.103086

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Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Authors: Pei Dai, Zhongxiang Tang, Pinglang Ruan, Ousman Bajinka, Dan Liu, Yurong Tan

Journal: Front Oncol

PubMed ID: 34604035

Doi: 10.3389/fonc.2021.699847

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Antibody Screening Results for Anti-Nucleocapsid Antibodies Toward the Development of a Lateral Flow Assay to Detect SARS-CoV-2 Nucleocapsid Protein

Authors: David M Cate, Joshua D Bishop, Helen V Hsieh, Veronika A Glukhova, Luis F Alonzo, H Gleda Hermansky, Brianda Barrios-Lopez, Benjamin D Grant, Caitlin E Anderson, Ethan Spencer, Samantha Kuhn, Ryan Gallagher, Rafael Rivera, Crissa Bennett, Samantha A Byrnes, John T Connelly, Puneet K Dewan, David S Boyle, Bernhard H Weigl, Kevin P Nichols

Journal: ACS Omega

PubMed ID: 34608447

Doi: 10.1021/acsomega.1c01253

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Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Authors: Byron Shue, Abhilash I Chiramel, Berati Cerikan, Thu-Hien To, Sonja Frölich, Stephen M Pederson, Emily N Kirby, Nicholas S Eyre, Ralf F W Bartenschlager, Sonja M Best, Michael R Beard

Journal: J Virol

PubMed ID: 34586867

Doi: 10.1128/JVI.00596-21

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Ackr3-Venus knock-in mouse lights up brain vasculature

Authors: Aliza T Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L Kieffer

Journal: Mol Brain

PubMed ID: 34583741

Doi: 10.1186/s13041-021-00862-y

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Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

Journal: J Clin Invest

PubMed ID: 34623328

Doi: 10.1172/JCI145472

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Identification of BvgA-Dependent and BvgA-Independent Small RNAs (sRNAs) in Bordetella pertussis Using the Prokaryotic sRNA Prediction Toolkit ANNOgesic

Authors: Kyung Moon, Minji Sim, Chin-Hsien Tai, Kyungyoon Yoo, Charlotte Merzbacher, Sung-Huan Yu, David D Kim, Jaehyun Lee, Konrad U Förstner, Qing Chen, Scott Stibitz, Leslie G Knipling, Deborah M Hinton

Journal: Microbiol Spectr

PubMed ID: 34550019

Doi: 10.1128/Spectrum.00044-21

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Baculovirus infection affects caterpillar chemoperception

Authors: Angel Llopis-Giménez, Gabriela Caballero-Vidal, Emmanuelle Jacquin-Joly, Cristina Maria Crava, Salvador Herrero

Journal: Insect Biochem Mol Biol

PubMed ID: 34536505

Doi: 10.1016/j.ibmb.2021.103648

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Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection

Authors: Hai Li, Hu Ren, Yan Zhang, Lei Cao, Wenbo Xu

Journal: Sci Rep

PubMed ID: 34545126

Doi: 10.1038/s41598-021-97535-6

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Authors: Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl

Journal: Elife

PubMed ID: 34486521

Doi: 10.7554/eLife.71420

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Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43

Authors: Takashi Shiroyama, Kouji Fukuyama, Motohiro Okada

Journal: Int J Mol Sci

PubMed ID: 34576176

Doi: 10.3390/ijms221810013

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The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients

Authors: Chanmi Kim, Iqra Latif, Durga P Neupane, Gi Young Lee, Ryan S Kwon, Alia Batool, Qasim Ahmed, Muhammad Usman Qamar, Jeongmin Song

Journal: PLoS ONE

PubMed ID: 34582469

Doi: 10.1371/journal.pone.0257744

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Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding

Authors: Abigail E Burgess, Torsten Kleffmann, Peter D Mace

Journal: J Mol Biol

PubMed ID: 34536441

Doi: 10.1016/j.jmb.2021.167242

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Impact of glgA1, glgA2 or glgC overexpression on growth and glycogen production in Synechocystis sp PCC 6803

Authors: Sandra Mittermair, Gergely Lakatos, Cecilia Nicoletti, Karolína Ranglová, João Câmara Manoel, Tomáš Grivalský, Daniyar Malikuly Kozhan, Jiří Masojídek, Juliane Richter

Journal: J Biotechnol

PubMed ID: 34481001

Doi: 10.1016/j.jbiotec.2021.08.012

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Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons

Authors: Hung-En Hsia, Johanna Tüshaus, Xiao Feng, Laura I Hofmann, Benedikt Wefers, Denise K Marciano, Wolfgang Wurst, Stefan F Lichtenthaler

Journal: FASEB J

PubMed ID: 34390512

Doi: 10.1096/fj.202100475R

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Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection

Authors: Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li, Xueping Zhou

Journal: PLoS Pathog

PubMed ID: 34570833

Doi: 10.1371/journal.ppat.1009956

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Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Authors: Raymond Rowland, Alberto Brandariz-Nuñez

Journal: Microbiol Spectr

PubMed ID: 34494876

Doi: 10.1128/Spectrum.01199-21

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The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Authors: Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie

Journal: Sci Adv

PubMed ID: 34516906

Doi: 10.1126/sciadv.abg9241

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Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

Authors: Andrew J Monteith, Jeanette M Miller, C Noel Maxwell, Walter J Chazin, Eric P Skaar

Journal: Sci Adv

PubMed ID: 34516771

Doi: 10.1126/sciadv.abj2101

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Switchable immune modulator for tumor-specific activation of anticancer immunity

Authors: Yu Zhao, Yu-Qing Xie, Simon Van Herck, Sina Nassiri, Min Gao, Yugang Guo, Li Tang

Journal: Sci Adv

PubMed ID: 34516776

Doi: 10.1126/sciadv.abg7291

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A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Authors: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J Marrink, Cornelius Gati, Albert Guskov

Journal: Comput Struct Biotechnol J

PubMed ID: 34630942

Doi: 10.1016/j.csbj.2021.09.015

Products & Services: Mammalian Expression

A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan

Authors: Marcus Bäumgen, Theresa Dutschei, Daniel Bartosik, Christoph Suster, Lukas Reisky, Nadine Gerlach, Christian Stanetty, Marko D Mihovilovic, Thomas Schweder, Jan-Hendrik Hehemann, Uwe T Bornscheuer

Journal: J Biol Chem

PubMed ID: 34547290

Doi: 10.1016/j.jbc.2021.101210

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Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Authors: Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li

Journal: Int J Biol Macromol

PubMed ID: 34499954

Doi: 10.1016/j.ijbiomac.2021.08.232

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A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

Authors: Juliano Alves, Laurie Engel, Renata de Vasconcelos Cabral, Eduardo L Rodrigues, Liane de Jesus Ribeiro, Luiza M Higa, Orlando da Costa Ferreira Júnior, Terezinha Marta P P Castiñeiras, Isabela de Carvalho Leitão, Amilcar Tanuri, Said A Goueli, Hicham Zegzouti

Journal: Sci Rep

PubMed ID: 34531417

Doi: 10.1038/s41598-021-97330-3

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Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Authors: John Pang, Nam Nguyen, Jens Luebeck, Laurel Ball, Andrey Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, Sayed Sadat, Paul S Mischel, Guorong Xu, Kathleen Fisch, Theresa Guo, Gabrielle Cahill, Bharat Panuganti, Vineet Bafna, Joseph Califano

Journal: Clin Cancer Res

PubMed ID: 34548317

Doi: 10.1158/1078-0432.CCR-21-2484

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Genome-scale identification of () family genes and molecular characterization of their responses to diverse nutrient stresses in allotetraploid rapeseed

Authors: Ying Liu, Ying-Peng Hua, Huan Chen, Ting Zhou, Cai-Peng Yue, Jin-Yong Huang

Journal: PeerJ

PubMed ID: 34603847

Doi: 10.7717/peerj.12007

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Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation

Authors: Jacquelyn R Dayton, Yinyu Yuan, Lisa P Pacumio, Bryce G Dorflinger, Samantha C Yoo, Mariah J Olson, Sara I Hernández-Suárez, Moira M McMahon, Lillian Cruz-Orengo

Journal: Front Cell Neurosci

PubMed ID: 34557075

Doi: 10.3389/fncel.2021.683687

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Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart

Authors: Yanbo Tang, Kevin T Kline, Xiaoying S Zhong, Ying Xiao, Haifeng Lian, Jun Peng, Xiaowei Liu, Don W Powell, Guodu Tang, Qingjie Li

Journal: PLoS ONE

PubMed ID: 34543287

Doi: 10.1371/journal.pone.0257280

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Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

Authors: Shang Yu Gong, Debashree Chatterjee, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Romain Gasser, Yuxia Bo, Dani Vézina, Guillaume Goyette, Gabrielle Gendron-Lepage, Halima Medjahed, Michel Roger, Marceline Côté, Andrés Finzi

Journal: Virology

PubMed ID: 34536797

Doi: 10.1016/j.virol.2021.09.001

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The impact of chromophore choice on the assembly kinetics and primary photochemistry of a red/green cyanobacteriochrome

Authors:

Journal: Phys Chem Chem Phys

PubMed ID: 34374395

Doi: 10.1039/d1cp02696h

Products & Services: Bacterial Expression

High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population

Authors: Arshad A Pandith, Usma Manzoor, Ina Amin, Abida Ahmad, Masarat Rashid, Mahrukh H Zargar, Shayesta Rah, Fayaz A Dar, Iqbal Qasim, Dheera Sanadhya

Journal: Arch Gynecol Obstet

PubMed ID: 34542677

Doi: 10.1007/s00404-021-06235-z

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Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes

Authors: Thomas Steele, Anhao Sam, Shawna Evans, Elizabeth Browning, Sheryl Krig, Katelyn Macias, Adarsh Konda, Salma Siddiqui, Blythe Durbin-Johnson, Paramita Ghosh, Ruth Vinall

Journal: Cancers (Basel)

PubMed ID: 34503235

Doi: 10.3390/cancers13174425

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Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

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Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2

Authors: Jorge Hernández-Bello, José Javier Morales-Núñez, Andrea Carolina Machado-Sulbarán, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Paulina Balcázar-Félix, Jesús Alberto Gutiérrez-Brito, José Alvaro Lomelí-Nieto, José Francisco Muñoz-Valle

Journal: Vaccines (Basel)

PubMed ID: 34579284

Doi: 10.3390/vaccines9091047

A human antibody against human endothelin receptor type A that exhibits antitumor potency

Authors: Man-Seok Ju, Hye-Mi Ahn, Seong-Gu Han, Sanghwan Ko, Jung-Hyun Na, Migyeong Jo, Chung Su Lim, Byoung Joon Ko, Yeon Gyu Yu, Won-Kyu Lee, Youn-Jae Kim, Sang Taek Jung

Journal: Exp Mol Med

PubMed ID: 34588605

Doi: 10.1038/s12276-021-00678-9

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Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells

Authors: Guojie Chen, Kai Wang, Guoshu Li, Leidong Wang, Yangyang Xiao, Bo Chen

Journal: Oncol Res

PubMed ID: 34588094

Doi: 10.3727/096504021X16328213967104

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Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34582499

Doi: 10.1371/journal.pone.0258005

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Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice

Authors: Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Journal: Plant Biotechnol J

PubMed ID: 34582079

Doi: 10.1111/pbi.13716

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An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates

Authors: Stephen Geoffrey Holt, Sally Mahmoud, Wasim Ahmed, Juan Manuel Acuna, Ayman Kamal Al Madani, Islam Eltantawy, Walid Abbas Zaher, Gareth John Goodier, Nawal Ahmed Al Kaabi, Ali Abdulkareem Al Obaidli

Journal: Nephrology (Carlton)

PubMed ID: 34569677

Doi: 10.1111/nep.13980

Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios-Athanasios Dimopoulos

Journal: Br J Haematol

PubMed ID: 34528249

Doi: 10.1111/bjh.17841

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miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Authors: Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao

Journal: Mol Med Rep

PubMed ID: 34468015

Doi: 10.3892/mmr.2021.12392

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Design and Selection of Engineered Lytic Proteins With Decolonizing Activity

Authors: Diana Gutiérrez, Lorena Rodríguez-Rubio, Patricia Ruas-Madiedo, Lucía Fernández, Ana Belén Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar García, Ana Rodríguez

Journal: Front Microbiol

PubMed ID: 34594314

Doi: 10.3389/fmicb.2021.723834

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A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing

Authors: Bokyung Son, Jennifer Patterson-West, Melissa Arroyo-Mendoza, Revathy Ramachandran, James R Iben, Jingen Zhu, Venigalla Rao, Emilios K Dimitriadis, Deborah M Hinton

Journal: Nucleic Acids Res

PubMed ID: 34365505

Doi: 10.1093/nar/gkab678

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High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells

Authors: Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F Sikorski, Aleksander Czogalla

Journal: Membranes (Basel)

PubMed ID: 34564532

Doi: 10.3390/membranes11090715

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A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie

Journal: Talanta

PubMed ID: 34635250

Doi: 10.1016/j.talanta.2021.122868

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The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial

Authors: Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J Harrison, Gareth Bond, Sarah P Blagden

Journal: Clin Cancer Res

PubMed ID: 34497073

Doi: 10.1158/1078-0432.CCR-21-1652

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Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis

Authors: Benjamin H Jenkins, Finlay Maguire, Guy Leonard, Joshua D Eaton, Steven West, Benjamin E Housden, David S Milner, Thomas A Richards

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34521754

Doi: 10.1073/pnas.2108874118

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Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration

Authors: Shumei Chia, Thomas Leung, Ivan Tan

Journal: Cell Rep

PubMed ID: 34525355

Doi: 10.1016/j.celrep.2021.109687

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PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Authors: Xingang Wang, Yan Zheng, Yu Wang

Journal: Clin Exp Med

PubMed ID: 34554318

Doi: 10.1007/s10238-021-00761-5

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Two novel SARS-CoV-2 surrogate virus neutralization assays are suitable for assessing successful immunization with mRNA-1273

Authors: Alexander Krüttgen, Maike Lauen, Hanna Klingel, Matthias Imöhl, Michael Kleines

Journal: J Virol Methods

PubMed ID: 34563583

Doi: 10.1016/j.jviromet.2021.114297

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Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics

Authors: Yuan Zhou, Li Zhang, You-Hua Xie, Jian Wu

Journal: Lab Invest

PubMed ID: 34497366

Doi: 10.1038/s41374-021-00663-w

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Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia

Authors: Lina Abou Saleh, Abigail Boyd, Ileana V Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A Barrington, Wito Richter

Journal: FASEB J

PubMed ID: 34383981

Doi: 10.1096/fj.202100495R

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Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Authors: Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez, Simon Trowitzsch

Journal: Nat Commun

PubMed ID: 34584079

Doi: 10.1038/s41467-021-25870-3

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Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro

Authors: Gang Wang, Jun Guan, Guojun Li, Fengtian Wu, Qin Yang, Chunhong Huang, Junwei Shao, Lichen Xu, Zixuan Guo, Qihui Zhou, Haihong Zhu, Zhi Chen

Journal: Dis Markers

PubMed ID: 34603560

Doi: 10.1155/2021/6803510

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Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression

Authors: Sheng Xu, Huanhuan Tan, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Ping Zhao, Qingyou Xia, Feng Wang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34525798

Doi: 10.1021/acsami.1c08409

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Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation

Authors: Lennart Pusch, Regine Brox, Karl Scheuer, Tadahiro Yokosawa, Mingjian Wu, Benjamin Apeleo Zubiri, Erdmann Spiecker, Klaus D Jandt, Dagmar Fischer, Holger Hackstein

Journal: Nanomedicine (Lond)

PubMed ID: 34523349

Doi: 10.2217/nnm-2021-0022

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Discovery of an Heparin-Binding Epidermal Growth Factor Domain Antibody from a Phage Library and Analysis of Its Inhibitory Effects in SKOV3 Cells

Authors: Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen

Journal: Cancer Biother Radiopharm

PubMed ID: 34529926

Doi: 10.1089/cbr.2021.0123

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METTL3-mediated mA RNA methylation promotes the anti-tumour immunity of natural killer cells

Authors: Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian

Journal: Nat Commun

PubMed ID: 34535671

Doi: 10.1038/s41467-021-25803-0

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Large chromosomal segment deletions by CRISPR/LbCpf1-mediated multiplex gene editing in soybean

Authors: Kaixuan Duan, Yuanyuan Cheng, Jing Ji, Chenchen Wang, Yongshu Wei, Yuanchao Wang

Journal: J Integr Plant Biol

PubMed ID: 34331750

Doi: 10.1111/jipb.13158

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Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes

Authors: Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski

Journal: PLoS ONE

PubMed ID: 34570823

Doi: 10.1371/journal.pone.0257977

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Expression, biochemical and structural characterization of high-specific-activity β-amylase from Bacillus aryabhattai GEL-09 for application in starch hydrolysis

Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen, Yue Huang

Journal: Microb Cell Fact

PubMed ID: 34537082

Doi: 10.1186/s12934-021-01649-5

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Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species

Authors: Samuel M Goodfellow, Robert A Nofchissey, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Yan Guo, Chunyan Ye, Gregory J Mertz, Kartik Chandran, Michelle Harkins, Daryl B Domman, Darrell L Dinwiddie, Steven B Bradfute

Journal: J Virol

PubMed ID: 34549977

Doi: 10.1128/JVI.01534-21

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The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Authors: Martin A Mecchia, Mariano García-Hourquet, Fidel Lozano-Elena, Ainoa Planas-Riverola, David Blasco-Escamez, Mar Marquès-Bueno, Santiago Mora-García, Ana I Caño-Delgado

Journal: Curr Biol

PubMed ID: 34529936

Doi: 10.1016/j.cub.2021.08.050

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Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors

Authors: Sangmin Lee

Journal: Biomolecules

PubMed ID: 34572577

Doi: 10.3390/biom11091364

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Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

Authors: Ryuta Baba, Kenji Oki, Celso E Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Journal: Mol Cell Endocrinol

PubMed ID: 34520814

Doi: 10.1016/j.mce.2021.111456

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Phycobilin heterologous production from the Rhodophyta Porphyridium cruentum

Authors: Erika Juliana Obando Montoya, Sonia Dorion, Lucía Atehortua-Garcés, Jean Rivoal

Journal: J Biotechnol

PubMed ID: 34500003

Doi: 10.1016/j.jbiotec.2021.09.001

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Genetic Diversity and Population Structure of Affecting Chickpea in Ethiopia

Authors: Gezahegne Getaneh, Tadele Tefera, Fikre Lemessa, Seid Ahmed, Tarekegn Fite, Jandouwe Villinger

Journal: J Fungi (Basel)

PubMed ID: 34682241

Doi: 10.3390/jof7100820

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Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

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Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Authors: Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Journal: Virol Sin

PubMed ID: 34581960

Doi: 10.1007/s12250-021-00444-1

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Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant Recipients

Authors: Martina Chiarucci, Sara Paolasini, Alessandro Isidori, Barbara Guiducci, Federica Loscocco, Maria Capalbo, Giuseppe Visani

Journal: Front Oncol

PubMed ID: 34552880

Doi: 10.3389/fonc.2021.737300

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Correction to: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934

Authors: Seshi R Sompuram, Emina E Torlakovic, Nils A 't Hart, Kodela Vani, Steven A Bogen

Journal: Mod Pathol

PubMed ID: 34493826

Doi: 10.1038/s41379-021-00898-4

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Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Authors: Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura

Journal: J Cell Biol

PubMed ID: 34499080

Doi: 10.1083/jcb.202103160

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Seroepidemiology of Infection in the General Population of Northern China: The Jidong Community Cohort Study

Authors: Jingwei Shui, Dongjie Xie, Jianhui Zhao, Cailing Ao, Hongqing Lin, Yuanhao Liang, Haiying Wang, Yingchun Dai, Shixing Tang

Journal: Front Microbiol

PubMed ID: 34650533

Doi: 10.3389/fmicb.2021.729016

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A bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions

Authors: Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk

Journal: Sci Rep

PubMed ID: 34584201

Doi: 10.1038/s41598-021-98810-2

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A versatile genetic engineering toolkit for E coli based on CRISPR-prime editing

Authors: Yaojun Tong, Tue S Jørgensen, Christopher M Whitford, Tilmann Weber, Sang Yup Lee

Journal: Nat Commun

PubMed ID: 34471126

Doi: 10.1038/s41467-021-25541-3

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Valorization of lignin components into gallate by integrated biological hydroxylation, O-demethylation, and aryl side-chain oxidation

Authors: Chenggu Cai, Zhaoxian Xu, Huarong Zhou, Sitong Chen, Mingjie Jin

Journal: Sci Adv

PubMed ID: 34516898

Doi: 10.1126/sciadv.abg4585

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Oriented in situ immobilization of a functional tyrosinase on microcrystalline cellulose effectively incorporates DOPA residues in bioengineered mussel adhesive protein

Authors: Suhyeok Kim, Gaeun Bae, Mincheol Shin, Eungsu Kang, Tae Yoon Park, Yoo Seong Choi, Hyung Joon Cha

Journal: Biotechnol J

PubMed ID: 34536060

Doi: 10.1002/biot.202100216

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Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

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Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

Authors: Taylor P Light, Delphine Brun, Pablo Guardado-Calvo, Riccardo Pederzoli, Ahmed Haouz, Frank Neipel, Félix A Rey, Kalina Hristova, Marija Backovic

Journal: PLoS Biol

PubMed ID: 34499637

Doi: 10.1371/journal.pbio.3001392

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A pH-engineering regenerative DNA tetrahedron ECL biosensor for the assay of SARS-CoV-2 RdRp gene based on CRISPR/Cas12a -activity

Authors: Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie

Journal: Chem Eng J

PubMed ID: 34539224

Doi: 10.1016/j.cej.2021.132472

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Visualized Multigene Editing System for

Authors: Cen Li, Jingwen Zhou, Shengqi Rao, Guocheng Du, Song Liu

Journal: ACS Synth Biol

PubMed ID: 34555894

Doi: 10.1021/acssynbio.1c00231

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in

Authors: Jianhua Li, Fanglin Xu, Dongni Ji, Chenfei Tian, Yuwei Sun, Ishmael Mutanda, Yuhong Ren, Yong Wang

Journal: Metab Eng Commun

PubMed ID: 34631421

Doi: 10.1016/j.mec.2021.e00185

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Oral Delivery of Novel Recombinant Elicit High Protection against Pulmonary and Skin Infections

Authors: Na Pan, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 34579221

Doi: 10.3390/vaccines9090984

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Metabolic engineering of Deinococcus radiodurans for pinene production from glycerol

Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar, Ivan Mijakovic

Journal: Microb Cell Fact

PubMed ID: 34565367

Doi: 10.1186/s12934-021-01674-4

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COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Authors: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arriga, Abraham Nyska, Pietro Di Lucia, Davide Marotta, Elisa Bono, Leonardo Giustini, Eleonora Sala, Chiara Perucchini, Jemma Paterson, Kathryn Ann Ryan, Amy-Rose Challis, Giulia Matusali, Francesca Colavita, Gianfranco Caselli, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Lorena Donnici, Matteo Conti, Raffaele De Francesco, Mirela Kuka, Gennaro Ciliberto, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Luca G Guidotti, Lucio Rovati, Matteo Iannacone, Luigi Aurisicchio

Journal: Mol Ther

PubMed ID: 34547465

Doi: 10.1016/j.ymthe.2021.09.011

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Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications

Authors: Ah-Young Song, Hyori Kim, Jung Min Kim, Sang-Hyun Hwang, Dae-Hyun Ko, Hun Sik Kim

Journal: ACS Appl Mater Interfaces

PubMed ID: 34486371

Doi: 10.1021/acsami.1c08986

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

Authors: Maria Y Sachkova, Eva-Lena Nordmann, Joan J Soto-Àngel, Yasmin Meeda, Bartłomiej Górski, Benjamin Naumann, Daniel Dondorp, Marios Chatzigeorgiou, Maike Kittelmann, Pawel Burkhardt

Journal: Curr Biol

PubMed ID: 34587474

Doi: 10.1016/j.cub.2021.09.005

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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T Lee, Sizun Jiang, Matthias S Matter, Carol H Yan, Jonathan B Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M Schürch, Pauline Chu, Han Chen, Anna K Stalder, David R McIlwain, Nicole A Borchard, Phillip A Gall, Sachi S Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M Duran, Kirsten D Mertz, Peter H Hwang, Jasmin D Haslbauer, Peter K Jackson, Thomas Menter, Raul Andino, Peter D Canoll, Adam S DeConde, Zara M Patel, Alexandar Tzankov, Garry P Nolan, Jayakar V Nayak

Journal: Cell Rep Med

PubMed ID: 34604819

Doi: 10.1016/j.xcrm.2021.100421

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