客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

页码: 99/536 每页显示数量

ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Authors: Fei Teng, Roser Tachó-Piñot, Biin Sung, Donna L Farber, Stefan Worgall, Hamida Hammad, Bart N Lambrecht, Matthew R Hepworth, Gregory F Sonnenberg

Journal: Cell Rep

PubMed ID: 34818549

Doi: 10.1016/j.celrep.2021.110051

Products & Services: Catalog Peptides

Unveiling mRNP composition by fluorescence correlation and cross-correlation spectroscopy using cell lysates

Authors: Àngels Mateu-Regué, Jan Christiansen, Frederik Otzen Bagger, Christian Hellriegel, Finn Cilius Nielsen

Journal: Nucleic Acids Res

PubMed ID: 34478550

Doi: 10.1093/nar/gkab751

Products & Services: Mutagenesis Services

TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9

Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao

Journal: iScience

PubMed ID: 34877491

Doi: 10.1016/j.isci.2021.103425

Products & Services: PCR Cloning and Subcloning

A nanocompartment system contributes to defense against oxidative stress in

Authors: Katie A Lien, Kayla Dinshaw, Robert J Nichols, Caleb Cassidy-Amstutz, Matthew Knight, Rahul Singh, Lindsay D Eltis, David F Savage, Sarah A Stanley

Journal: Elife

PubMed ID: 34751132

Doi: 10.7554/eLife.74358

Products & Services: Polyclonal Antibody Services

Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases

Authors: Mariam Bakshi, Wenbin Tuo, Raffi V Aroian, Dante Zarlenga

Journal: Parasit Vectors

PubMed ID: 34798906

Doi: 10.1186/s13071-021-05010-y

Products & Services: Protein and Antibody Isolation

Gain of Spontaneous Mutations Boosting Motility Adaption to Environments in

Authors: Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Journal: Front Bioeng Biotechnol

PubMed ID: 34900963

Doi: 10.3389/fbioe.2021.772397

Products & Services: Catalog Antibodies

Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Authors: Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

Journal: Aging (Albany NY)

PubMed ID: 34739394

Doi: 10.18632/aging.203662

Products & Services: Custom DNA/RNA Oligos

Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression

Authors: Jianing Wang, Xiaoying Qin, Hao Sun, Meijun He, Qunyu Lv, Congcong Gao, Xinran He, Hong Liao

Journal: Aging Cell

PubMed ID: 34821024

Doi: 10.1111/acel.13515

Products & Services: Custom DNA/RNA Oligos

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Authors: Fabian Zech, Daniel Schniertshauer, Christoph Jung, Alexandra Herrmann, Arne Cordsmeier, Qinya Xie, Rayhane Nchioua, Caterina Prelli Bozzo, Meta Volcic, Lennart Koepke, Janis A Müller, Jana Krüger, Sandra Heller, Steffen Stenger, Markus Hoffmann, Stefan Pöhlmann, Alexander Kleger, Timo Jacob, Karl-Klaus Conzelmann, Armin Ensser, Konstantin M J Sparrer, Frank Kirchhoff

Journal: Nat Commun

PubMed ID: 34824253

Doi: 10.1038/s41467-021-27180-0

Products & Services: Catalog Antibodies

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Authors: Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck

Journal: Nat Commun

PubMed ID: 34815397

Doi: 10.1038/s41467-021-26882-9

Products & Services: Custom DNA/RNA Oligos

Plant LHC-like proteins show robust folding and static non-photochemical quenching

Authors: Petra Skotnicová, Hristina Staleva-Musto, Valentyna Kuznetsova, David Bína, Minna M Konert, Shan Lu, Tomáš Polívka, Roman Sobotka

Journal: Nat Commun

PubMed ID: 34824207

Doi: 10.1038/s41467-021-27155-1

Products & Services: Gene Synthesis

Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization

Authors: Adeline E Williams, Gaurav Shrivastava, Apostolos G Gittis, Sundar Ganesan, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Ken E Olson, Eric Calvo

Journal: Int J Mol Sci

PubMed ID: 34884537

Doi: 10.3390/ijms222312733

Products & Services: Protein and Antibody Isolation

SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II

Authors: Richard King, Zesen Lin, Ginette Balbin-Cuesta, Gregg Myers, Ann Friedman, Guojing Zhu, Beth McGee, Thomas L Saunders, Ryo Kurita, Yukio Nakamura, James Douglas Engel, Pavan Reddy, Rami Khoriaty

Journal: Sci Adv

PubMed ID: 34818036

Doi: 10.1126/sciadv.abj5293

Products & Services: Codon Optimization

Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells

Authors: Ana Stojiljković, Véronique Gaschen, Franck Forterre, Ulrich Rytz, Michael H Stoffel, Jasmin Bluteau

Journal: Geroscience

PubMed ID: 34806133

Doi: 10.1007/s11357-021-00488-x

Products & Services: ORF cDNA Clones/MolecularCloud

Comprehensive Comparative Analysis of the GATA Transcription Factors in Four Rosaceae Species and Phytohormonal Response in Chinese Pear () Fruit

Authors: Muhammad Aamir Manzoor, Irfan Ali Sabir, Iftikhar Hussain Shah, Han Wang, Zhao Yu, Faiz Rasool, Muhammad Zaid Mazhar, Shoaib Younas, Muhammad Abdullah, Yongping Cai

Journal: Int J Mol Sci

PubMed ID: 34830372

Doi: 10.3390/ijms222212492

Products & Services: Molecular Biology Tools

Hsa_circRNA_103124 Upregulation in Crohn's Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway

Authors: Juan Yin, Fuyi Tong, Yulan Ye, Tong Hu, Lijuan Xu, Liping Zhang, Jianyun Zhu, Zhi Pang

Journal: Front Genet

PubMed ID: 34804121

Doi: 10.3389/fgene.2021.753161

Products & Services: Gene Synthesis

An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function

Authors: Yuanyong Huang, Xiaoya Duan, Zhen Wang, Yimei Sun, Qingqing Guan, Li Kang, Qiao Zhang, Lan Fang, Jiwen Li, Jiemin Wong

Journal: J Biol Chem

PubMed ID: 34762910

Doi: 10.1016/j.jbc.2021.101389

Products & Services: Gene Synthesis

His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation

Authors: Gabrielle Parkinson, Peristera Roboti, Ling Zhang, Sandra Taylor, Philip Woodman

Journal: J Cell Sci

PubMed ID: 34657963

Doi: 10.1242/jcs.259192

Products & Services: Catalog Antibodies

Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration and angiogenesis of keratinocytes by modulating heparanase stability

Authors: Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang

Journal: Bioengineered

PubMed ID: 34753397

Doi: 10.1080/21655979.2021.2002495

Products & Services: ORF cDNA Clones/MolecularCloud

Serine palmitoyltransferase assembles at ER-mitochondria contact sites

Authors: Mari J Aaltonen, Irina Alecu, Tim König, Steffany Al Bennett, Eric A Shoubridge

Journal: Life Sci Alliance

PubMed ID: 34785538

Doi: 10.26508/lsa.202101278

Products & Services: Catalog Antibodies

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Authors: Pim J Huis In 't Veld, Sabine Wohlgemuth, Carolin Koerner, Franziska Müller, Petra Janning, Andrea Musacchio

Journal: Protein Sci

PubMed ID: 34791727

Doi: 10.1002/pro.4233

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets

Authors: Syam Prakash Somasekharan, Martin Gleave

Journal: FEBS Lett

PubMed ID: 34780058

Doi: 10.1002/1873-3468.14229

Products & Services: Catalog Antibodies

Antiseptic 9-Meric Peptide with Potency against Carbapenem-Resistant Infection

Authors: Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Young Kyung Yoon, Yangmee Kim

Journal: Int J Mol Sci

PubMed ID: 34830401

Doi: 10.3390/ijms222212520

Products & Services: Endotoxin Detection & Removal System

Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set

Authors: Peter Hayes, Natalia Fernandez, Christina Ochsenbauer, Jama Dalel, Jonathan Hare, Deborah King, Lucas Black, Claire Streatfield, Vanaja Kakarla, Gladys Macharia, Julia Makinde, Matt Price, Eric Hunter, Jill Gilmour

Journal: PLoS ONE

PubMed ID: 34788349

Doi: 10.1371/journal.pone.0260118

Products & Services: Catalog Peptides

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Authors: Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito

Journal: Commun Biol

PubMed ID: 34764413

Doi: 10.1038/s42003-021-02801-y

Products & Services: Gene Synthesis

Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression

Authors: Yuhua He, Shuifang Xu, Yi Qi, Jinfang Tian, Fengying Xu

Journal: J Ovarian Res

PubMed ID: 34789312

Doi: 10.1186/s13048-021-00906-w

Products & Services: Plasmid DNA Preparation

Comparison of Antibody Response Elicited by ChAdOx1 and BNT162b2 COVID-19 Vaccine

Authors: Yu Min Kang, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Dong Ho Jo, Kang-Won Choe, Moon Jung Kim, Jong Min Kim, Kwang Nam Kim

Journal: J Korean Med Sci

PubMed ID: 34845875

Doi: 10.3346/jkms.2021.36.e311

Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus

Authors: Suyeon Hong, Shaobo Ruan, Zachary Greenberg, Mei He, Jodi L McGill

Journal: Sci Rep

PubMed ID: 34725399

Doi: 10.1038/s41598-021-00765-x

Products & Services: Peptide Synthesis

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Authors: Lorna M Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F Burrows, Ian G Mills, Emma Evergren

Journal: Cell Death Dis

PubMed ID: 34725334

Doi: 10.1038/s41419-021-04335-x

Products & Services: Peptide Synthesis

Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea

Authors: Yu Kyung Kim, Dohsik Minn, Do Young Song, Chae Hoon Lee, Nam Hee Ryoo, Chang-Ho Jeon, Kyung Eun Song, Jang Soo Suh, Soon Hee Chang

Journal: J Korean Med Sci

PubMed ID: 34751011

Doi: 10.3346/jkms.2021.36.e294

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1

Authors: Ruing Zhao, Wei Yin, Qingqing Yu, Yanjiao Mao, Qinghua Deng, Ke Zhang, Shenglin Ma

Journal: Bioengineered

PubMed ID: 34738874

Doi: 10.1080/21655979.2021.2001238

Products & Services: Gene Synthesis

Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection

Authors: Heni Muflihah, Manuela Flórido, Leon C W Lin, Yingju Xia, James A Triccas, John Stambas, Warwick J Britton

Journal: PLoS ONE

PubMed ID: 34793507

Doi: 10.1371/journal.pone.0259829

Products & Services: Catalog Peptides

Improved Sensitivity of Allergen Detection by Immunoaffinity LC-MS/MS Using Ovalbumin as a Case Study

Authors: Martin Röder, Claudia Wiacek, Frauke Lankamp, Jonathan Kreyer, Wolfgang Weber, Elke Ueberham

Journal: Foods

PubMed ID: 34945483

Doi: 10.3390/foods10122932

Products & Services: Peptide Synthesis

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Authors: Cristina Gil-Cruz, Christian Perez-Shibayama, Angelina De Martin, Francesca Ronchi, Katrien van der Borght, Rebekka Niederer, Lucas Onder, Mechthild Lütge, Mario Novkovic, Veronika Nindl, Gustavo Ramos, Markus Arnoldini, Emma M C Slack, Valérie Boivin-Jahns, Roland Jahns, Madeleine Wyss, Catherine Mooser, Bart N Lambrecht, Micha T Maeder, Hans Rickli, Lukas Flatz, Urs Eriksson, Markus B Geuking, Kathy D McCoy, Burkhard Ludewig

Journal: Science

PubMed ID: 31727837

Doi: 10.1126/science.aav3487

Products & Services: Peptide Synthesis Peptide Library Services

Label-free analytical characterization of brazzein produced with the filamentous fungus Trichoderma reesei

Authors: Dominik Mojzita; Nina Aro; Juha Kontturi; Martin K gler; Emilia Nordlund; Waltteri Hosia; Marco G. Casteleijn

Journal: Frontiers in bioengineering and biotechnology

PubMed ID: 41459251

Doi: 10.3389/fbioe.2025.1688495

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Authors: Pan Pan; Miaomiao Shen; Zhenyang Yu; Weiwei Ge; Keli Chen; Mingfu Tian; Feng Xiao; Zhenwei Wang; Jun Wang; Yaling Jia; Wenbiao Wang; Pin Wan; Jing Zhang; Weijie Chen; Zhiwei Lei; Xin Chen; Zhen Luo; Qiwei Zhang; Meng Xu; Geng Li; Yongkui Li; Jianguo Wu

Journal: Nature Communications

PubMed ID: 34341353

Doi: 10.1038/s41467-021-25015-6

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling

Authors: Zheyue Wang; Qi Tang; Bende Liu; Wenqing Zhang; Yufeng Chen; Ningfei Ji; Yan Peng; Xiaohui Yang; Daixun Cui; Weiyu Kong; Xiaojun Tang; Tingting Yang; Mingshun Zhang; Xinxia Chang; Jin Zhu; Mao Huang; Zhenqing Feng

Journal: Journal of biomedical research

PubMed ID: 36992606

Doi: 10.7555/JBR.36.20220221

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling

Journal: Journal of biomedical research

PubMed ID: 36992606

Doi: 10.7555/JBR.36.20220221

Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A

Authors: Kristina Jonsson-Schmunk; Romi Ghose; Maria A. Croyle

Journal: Expert review of vaccines

PubMed ID: 33666138

Doi: 10.1080/14760584.2021.1899818

Products & Services: Peptide Synthesis

HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

Authors: Man Chen; Madhav C. Menon; Wenlin Wang; Jia Fu; Zhengzi Yi; Zeguo Sun; Jessica Liu; Zhengzhe Li; Lingyun Mou; Khadija Banu; Sui-Wan Lee; Ying Dai; Nanditha Anandakrishnan; Evren U. Azeloglu; Kyung Lee; Weijia Zhang; Bhaskar Das; John Cijiang He; Chengguo Wei

Journal: Nature Communications

PubMed ID: 37463911

Doi: 10.1038/s41467-023-40086-3

Products & Services: Catalog Antibodies

Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein

Authors: Hristo L Svilenov, Julia Sacherl, Alwin Reiter, Lisa S Wolff, Cho-Chin Cheng, Marcel Stern, Vincent Grass, Martin Feuerherd, Frank-Peter Wachs, Nicole Simonavicius, Susanne Pippig, Florian Wolschin, Oliver T Keppler, Johannes Buchner, Carsten Brockmeyer, Ulrike Protzer

Journal: Antiviral Res

PubMed ID: 34774603

Doi: 10.1016/j.antiviral.2021.105197

Products & Services: Protein and Antibody Reagents

Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

Authors: Haiyan Hong, Zilong Guo, Hao Sun , Ping Yu , Huanhuan Su , Xuening Ma & Hu Chen

Journal: Communications Chemistry

Doi: doi.org/10.1038/s42004-021-00592-1

Products & Services: Gene Synthesis

Kinetics of anti-SARS-CoV-2 neutralizing antibodies development after BNT162b2 vaccination in patients with amyloidosis and the impact of therapy

Authors: Efstathios Kastritis, Evangelos Terpos, Zoi Evangelakou, Foteini Theodorakakou, Despina Fotiou, Maria S Manola, Despoina D Gianniou, Tina Bagratuni, Nikolaos Kanellias, Magdalini Migkou, Maria Gavriatopoulou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Am J Hematol

PubMed ID: 34778995

Doi: 10.1002/ajh.26406

Products & Services: Catalog Antibodies

Performance Evaluation of the BZ COVID-19 Neutralizing Antibody Test for the Culture-Free and Rapid Detection of SARS-CoV-2 Neutralizing Antibodies

Authors: Bo Kyeung Jung, Jung Yoon, Joon-Yong Bae, Jeonghun Kim, Man-Seong Park, Suk Yong Lee, Chae Seung Lim

Journal: Diagnostics (Basel)

PubMed ID: 34943430

Doi: 10.3390/diagnostics11122193

Products & Services: Protein and Antibody Reagents

PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

Authors: Fengxiang Wang, Emily T Graham, Nathchar Naowarojna, Zhennan Shi, Yuqi Wang, Guanglei Xie, Lili Zhou, Wendy Salmon, Jie-Min Jia, Xi Wang, Yuwei Huang, Stuart L Schreiber, Yilong Zou

Journal: Cell Chem Biol

PubMed ID: 34813762

Doi: 10.1016/j.chembiol.2021.11.001

Products & Services: Protein Electrophoresis and Western

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

Authors: Xuankang Wang, Xin Li, Xiaoshuang Zuo, Zhuowen Liang, Tan Ding, Kun Li, Yangguang Ma, Penghui Li, Zhijie Zhu, Cheng Ju, Zhihao Zhang, Zhiwen Song, Huilin Quan, Jiawei Zhang, Xueyu Hu, Zhe Wang

Journal: J Neuroinflammation

PubMed ID: 34740378

Doi: 10.1186/s12974-021-02312-x

Products & Services: Protein Electrophoresis and Western

3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels

Authors: Niraimathi Govindasamy, Hongyan Long, Hyun-Woo Jeong, Ratish Raman, Burak Özcifci, Simone Probst, Sebastian J Arnold, Kristina Riehemann, Adrian Ranga, Ralf H Adams, Britta Trappmann, Ivan Bedzhov

Journal: Dev Cell

PubMed ID: 34741805

Doi: 10.1016/j.devcel.2021.10.014

Products & Services: Protein and Antibody Isolation

Capillary electrophoresis-based functional genomics screening to discover novel archaeal DNA modifying enzymes

Authors: Kelly M Zatopek, Samantha L Fossa, Katharina Bilotti, Paul J Caffrey, Léa Chuzel, Alexandra M Gehring, Gregory J S Lohman, Christopher H Taron, Andrew F Gardner

Journal: Appl Environ Microbiol

PubMed ID: 34788065

Doi: 10.1128/AEM.02137-21

Products & Services: Plasmid DNA Preparation

New highly antigenic linear B cell epitope peptides from PvAMA-1 as potential vaccine candidates

Authors: Raianna F Fantin, Vanessa G Fraga, Camila A Lopes, Isabella C de Azevedo, João L Reis-Cunha, Dhelio B Pereira, Francisco P Lobo, Marcela M de Oliveira, Anderson C Dos Santos, Daniela C Bartholomeu, Ricardo T Fujiwara, Lilian L Bueno

Journal: PLoS ONE

PubMed ID: 34727117

Doi: 10.1371/journal.pone.0258637

Products & Services: Plasmid DNA Preparation

The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

Authors: Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K Simanshu, Jairaj K Acharya, Douglas R Lowy

Journal: Mol Cancer

PubMed ID: 34727930

Doi: 10.1186/s12943-021-01439-y

Products & Services: PCR Cloning and Subcloning

The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses

Authors: David M Picton, Yvette A Luyten, Richard D Morgan, Andrew Nelson, Darren L Smith, David T F Dryden, Jay C D Hinton, Tim R Blower

Journal: Nucleic Acids Res

PubMed ID: 34657954

Doi: 10.1093/nar/gkab906

Products & Services: Mutant Libraries

Effector-mediated membrane disruption controls cell death in CBASS antiphage defense

Authors: Brianna Duncan-Lowey, Nora K McNamara-Bordewick, Nitzan Tal, Rotem Sorek, Philip J Kranzusch

Journal: Mol Cell

PubMed ID: 34784509

Doi: 10.1016/j.molcel.2021.10.020

Products & Services: Mutant Libraries

Stress Induced Transcription Factors Transactivate the Herpes Simplex Virus 1 Infected Cell Protein 27 (ICP27) Transcriptional Enhancer

Authors: Jeffery B Ostler, Clinton Jones

Journal: Viruses

PubMed ID: 34835102

Doi: 10.3390/v13112296

Products & Services: Mutant Libraries

A mosquito AgTRIO monoclonal antibody reduces early infection of mice

Authors: Yu-Min Chuang, Xu-Dong Tang, Erol Fikrig

Journal: Infect Immun

PubMed ID: 34724388

Doi: 10.1128/IAI.00359-21

Products & Services: Insect Expression Monoclonal Antibody Services Peptide Synthesis

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Authors: Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola

Journal: Nat Commun

PubMed ID: 34795280

Doi: 10.1038/s41467-021-27075-0

Products & Services: Gene Fragments

Structures of prokaryotic ubiquitin-like protein Pup in complex with depupylase Dop reveal the mechanism of catalytic phosphate formation

Authors: Hengjun Cui, Andreas U Müller, Marc Leibundgut, Jiawen Tian, Nenad Ban, Eilika Weber-Ban

Journal: Nat Commun

PubMed ID: 34789727

Doi: 10.1038/s41467-021-26848-x

Products & Services: Gene Fragments

Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan

Authors: Yang Ai, Ben Wang, Shuai Xiao, Sang Luo, Yefu Wang

Journal: Int J Mol Sci

PubMed ID: 34830310

Doi: 10.3390/ijms222212428

Products & Services: Endotoxin Detection & Removal System

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

Authors: Wooseob Kim, Julian Q Zhou, Alexandria J Sturtz, Stephen C Horvath, Aaron J Schmitz, Tingting Lei, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: biorxiv

PubMed ID: 34751268

Doi: 10.1101/2021.10.31.466651

Products & Services: Custom Vector Construction

MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1

Authors: Chun Liu, Yang Yang, Guiwen Liang, Aixian Zhang, Feng Xu

Journal: Transpl Immunol

PubMed ID: 34774740

Doi: 10.1016/j.trim.2021.101493

Products & Services: Custom Vector Construction

T cell receptor therapy targeting mutant capicua transcriptional repressor in experimental gliomas

Authors: Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin Löwer, Jana K Sonner, Christopher Krämer, Julia Zaman, Stefanie Jung, Michael O Breckwoldt, Gerald Willimksy, Stefan B Eichmüller, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten, Lukas Bunse

Journal: Clin Cancer Res

PubMed ID: 34782365

Doi: 10.1158/1078-0432.CCR-21-1881

Products & Services: Custom DNA/RNA Oligos

Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus

Authors: Ebru Destan, Busra Yuksel, Bradley B Tolar, Esra Ayan, Sam Deutsch, Yasuo Yoshikuni, Soichi Wakatsuki, Christopher A Francis, Hasan DeMirci

Journal: Sci Rep

PubMed ID: 34819551

Doi: 10.1038/s41598-021-02180-8

Products & Services: Codon Optimization

Proteolytic processing of plant proteins by potyvirus NIa proteases

Authors: Huogen Xiao, Etienne Lord, Hélène Sanfaçon

Journal: J Virol

PubMed ID: 34757836

Doi: 10.1128/JVI.01444-21

Products & Services: Codon Optimization

Structure of native HIV-1 cores and their interactions with IP6 and CypA

Authors: Tao Ni, Yanan Zhu, Zhengyi Yang, Chaoyi Xu, Yuriy Chaban, Tanya Nesterova, Jiying Ning, Till Böcking, Michael W Parker, Christina Monnie, Jinwoo Ahn, Juan R Perilla, Peijun Zhang

Journal: Sci Adv

PubMed ID: 34797722

Doi: 10.1126/sciadv.abj5715

Products & Services: Codon Optimization

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

Authors: Jonathan P Renn, Justin Y A Doritchamou, Bergeline C Nguemwo Tentokam, Robert D Morrison, Matthew V Cowles, Martin Burkhardt, Rui Ma, Niraj H Tolia, Michal Fried, Patrick E Duffy

Journal: Commun Biol

PubMed ID: 34799664

Doi: 10.1038/s42003-021-02787-7

Products & Services: Codon Optimization

Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Case

Authors: Enrico König, Assunta Gagliardi, Ilary Riedmiller, Chiara Andretta, Michele Tomasi, Carmela Irene, Luca Frattini, Ilaria Zanella, Francesco Berti, Alberto Grandi, Elena Caproni, Laura Fantappiè, Guido Grandi

Journal: Front Immunol

PubMed ID: 34819933

Doi: 10.3389/fimmu.2021.752168

Products & Services: Catalog Peptides

Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy

Authors: Jun Zheng, Xi Chen, Qiang Liu, Guisheng Zhong, Min Zhuang

Journal: J Cell Biol

PubMed ID: 34747980

Doi: 10.1083/jcb.202103156

Products & Services: Catalog Antibodies

Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice

Authors: Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou, Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J Bäumler, Cheng-Yuan Kao

Journal: Cell Rep

PubMed ID: 34818535

Doi: 10.1016/j.celrep.2021.110016

Products & Services: Recombinant Proteins

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains*

Authors: Karen T Elvers, Magdalena Lipka-Lloyd, Rebecca C Trueman, Benjamin D Bax, Youcef Mehellou

Journal: Chembiochem

PubMed ID: 34726826

Doi: 10.1002/cbic.202100441

Products & Services: Gene Synthesis

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Authors: Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang

Journal: Endocr Connect

PubMed ID: 34678757

Doi: 10.1530/EC-21-0179

Products & Services: Recombinant Proteins

Structure of Rift Valley fever virus RNA-dependent RNA polymerase

Authors: Xue Wang, Cuixia Hu, Wei Ye, Jia Wang, Xiaofei Dong, Jie Xu, Xiaorong Li, Manfeng Zhang, Hongyun Lu, Fanglin Zhang, Wei Wu, Shaodong Dai, Hong-Wei Wang, Zhongzhou Chen

Journal: J Virol

PubMed ID: 34787453

Doi: 10.1128/JVI.01713-21

Products & Services: Protein and Antibody Isolation

Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease

Authors: Sukanya Srinivasan, Jozsef Gal, Adam Bachstetter, Peter T Nelson

Journal: Neuropathol Appl Neurobiol

PubMed ID: 34820873

Doi: 10.1111/nan.12776

Products & Services: Catalog Antibodies

ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca in Spodoptera litura

Authors: Xue Yao, Chen Liu, Yunpeng Duan, Shiheng An, Jizhen Wei, Gemei Liang

Journal: Int J Biol Macromol

PubMed ID: 34861271

Doi: 10.1016/j.ijbiomac.2021.11.174

Products & Services: Recombinant Proteins

Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides

Authors: Maria Carmina Scala, Simone Di Micco, Delia Lanzillotta, Simona Musella, Veronica Di Sarno, Barbara Parrino, Stella Maria Casciofierro, Giuseppe Bifulco, Francesco Trapasso, Pietro Campiglia, Marina Sala

Journal: Front Mol Biosci

PubMed ID: 34901149

Doi: 10.3389/fmolb.2021.715263

Products & Services: Recombinant Proteins

Molecular characterization of substrate-induced ubiquitin transfer by UBR7-PHD finger, a newly identified histone H2BK120 ubiquitin ligase

Authors: Anirban Dasgupta, Payel Mondal, Sambit Dalui, Chandrima Das, Siddhartha Roy

Journal: FEBS J

PubMed ID: 34739193

Doi: 10.1111/febs.16262

Products & Services: Recombinant Proteins

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Authors: Eline van Diest, Patricia Hernández López, Angelo D Meringa, Anna Vyborova, Froso Karaiskaki, Sabine Heijhuurs, Jan Gumathi Bormin, Sanne van Dooremalen, Mara J T Nicolasen, Lucrezia C D E Gatti, Inez Johanna, Trudy Straetemans, Zsolt Sebestyén, Dennis X Beringer, Jürgen Kuball

Journal: J Immunother Cancer

PubMed ID: 34815357

Doi: 10.1136/jitc-2021-003850

Products & Services: Peptide Synthesis

The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid

Authors: Anton A Stepnov, Idd A Christensen, Zarah Forsberg, Finn L Aachmann, Gaston Courtade, Vincent G H Eijsink

Journal: FEBS Lett

PubMed ID: 34845720

Doi: 10.1002/1873-3468.14246

Products & Services: Gene Synthesis

Structural characterization of the porcine adeno-associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha

Authors: Mikayla Hoad, Justin A Roby, Jade K Forwood

Journal: FEBS Lett

PubMed ID: 34661283

Doi: 10.1002/1873-3468.14209

Products & Services: Bacterial Expression

A simple PCR-RFLP method for identification and detection of medicinal toad and its crude drug even with serious degradation of DNA

Authors: Jiao Liu, Xinyi Shao, Ziying Zhou, Miao Lei, Mingyu Xia, Dong Wang

Journal: J Pharm Biomed Anal

PubMed ID: 34864355

Doi: 10.1016/j.jpba.2021.114495

Products & Services: Custom DNA/RNA Oligos

1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells

Authors: Yanqi Li, Ping Deng, Chunhai Chen, Qinlong Ma, Huifeng Pi, Mindi He, Yonghui Lu, Peng Gao, Chao Zhou, Zhixin He, Yanwen Zhang, Zhengping Yu, Lei Zhang

Journal: Front Public Health

PubMed ID: 34881219

Doi: 10.3389/fpubh.2021.771508

Products & Services: Gene Synthesis

MLL1 is regulated by KSHV LANA and is important for virus latency

Authors: Min Tan, Shijun Li, Franceline Juillard, Rute Chitas, Tânia F Custódio, Han Xue, Agnieszka Szymula, Qiming Sun, Bing Liu, Ángel L Álvarez, She Chen, Jing Huang, J Pedro Simas, Colin E McVey, Kenneth M Kaye

Journal: Nucleic Acids Res

PubMed ID: 34850113

Doi: 10.1093/nar/gkab1094

Products & Services: Peptide Synthesis

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines

Authors: Shengli Song, Miriam Manook, Jean Kwun, Annette M Jackson, Stuart J Knechtle, Garnett Kelsoe

Journal: Commun Biol

PubMed ID: 34824350

Doi: 10.1038/s42003-021-02881-w

Products & Services: Gene Synthesis

Protoplast isolation and transcriptome analysis of developing xylem in Pinus massoniana (Pinaceae)

Authors: Tengfei Shen, Mengxuan Xu, Haoran Qi, Yuanheng Feng, Zhangqi Yang, Meng Xu

Journal: Mol Biol Rep

PubMed ID: 34826048

Doi: 10.1007/s11033-021-06995-6

Products & Services: Custom DNA/RNA Oligos

Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Authors: Hamid Reza Kouhpayeh, Farhad Tabasi, Mohammad Dehvari, Mohammad Naderi, Gholamreza Bahari, Tahereh Khalili, Courtney Clark, Saeid Ghavami, Mohsen Taheri

Journal: Transl Med Commun

PubMed ID: 34805533

Doi: 10.1186/s41231-021-00106-0

Products & Services: Gene Synthesis

Fecal microbiota changes in NZB/W F1 mice after induction of lupus disease

Authors: Yen-Fu Chen, Ao-Ho Hsieh, Lian-Chin Wang, Yun-Ju Huang, Wen-Yi Tseng, Yu-Lun Kuo, Shue-Fen Luo, Kuang-Hui Yu, Chang-Fu Kuo

Journal: Sci Rep

PubMed ID: 34824318

Doi: 10.1038/s41598-021-02422-9

Products & Services: Peptide Synthesis

Limited Impact of Delta Variant's Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: Viruses

PubMed ID: 34960674

Doi: 10.3390/v13122405

Products & Services: Catalog Antibodies

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Authors: Christian Kretzer, Paul M Jordan, Katharina P L Meyer, Daniel Hoff, Markus Werner, Robert Klaus Hofstetter, Andreas Koeberle, Antonio Cala Peralta, Guillaume Viault, Denis Seraphin, Pascal Richomme, Jean-Jacques Helesbeux, Hermann Stuppner, Veronika Temml, Daniela Schuster, Oliver Werz

Journal: Biochem Pharmacol

PubMed ID: 34762841

Doi: 10.1016/j.bcp.2021.114825

Products & Services: Catalog Peptides

Backbone H, N, and C resonance assignments of the non-structural protein NS2B of Zika virus

Authors: Beatriz Rosa Penna, Danielle Maria P de Oliveira, Cristiane Dinis Anobom, Ana Paula Valente

Journal: Biomol NMR Assign

PubMed ID: 34817802

Doi: 10.1007/s12104-021-10055-2

Products & Services: Codon Optimization

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Authors: Jill P Smith, Hong Cao, Elijah F Edmondson, Siva Sai Krishna Dasa, Stephan T Stern

Journal: Biomolecules

PubMed ID: 34944412

Doi: 10.3390/biom11121766

Products & Services: Catalog Peptides

The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

Products & Services: Catalog Antibodies

Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

Products & Services: DNA Sequencing

Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus

Authors: Mintu Chandra, Brett M Collins, Lauren P Jackson

Journal: Adv Biol Regul

PubMed ID: 34866035

Doi: 10.1016/j.jbior.2021.100842

Products & Services: Catalog Peptides

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

Products & Services: Custom Vector Construction

Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses

Authors: Vijaya L Simhadri, Joseph R McGill, Zuben E Sauna

Journal: Gene Ther

PubMed ID: 34744169

Doi: 10.1038/s41434-021-00301-6

Products & Services: Protein and Antibody Isolation

Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes

Authors: Novalia Pishesha, Thibault Harmand, Liyan Y Smeding, Weiyi Ma, Leif S Ludwig, Robine Janssen, Ashraful Islam, Yushu J Xie, Tao Fang, Nicholas McCaul, William Pinney, Harun R Sugito, Martin A Rossotti, Gualberto Gonzalez-Sapienza, Hidde L Ploegh

Journal: Nature biomedical engineering

PubMed ID: 34127819

Doi: doi.org/10.1038/s41551-021-00738-5

Products & Services: Peptide Synthesis

Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Authors: Marcel V Alavi

Journal: Biochim Biophys Acta Mol Cell Res.

PubMed ID: 34400172

Doi: 10.1016/j.bbamcr.2021.119116

Products & Services: Custom Vector Construction

Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Authors: Sai Shashank Chavali, Sachitanand M Mali, Rachel Bonn, Abhijith Saseendran Anitha, Ryan P Bennett, Harold C Smith, Rudi Fasan, Joseph E Wedekind

Journal: J Biol Chem.

PubMed ID: 34767799

Doi: 10.1016/j.jbc.2021.101390

Products & Services: Peptide Synthesis

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

Authors: Matthew McCallum, Alexandra C Walls, Kaitlin R Sprouse, John E Bowen, Laura E Rosen, Ha V Dang, Anna De Marco, Nicholas Franko, Sasha W Tilles, Jennifer Logue, Marcos C Miranda, Margaret Ahlrichs, Lauren Carter, Gyorgy Snell, Matteo Samuele Pizzuto, Helen Y Chu, Wesley C Van Voorhis, Davide Corti, David Veesler

Journal: Science

PubMed ID: 34751595

Doi: 10.1126/science.abl8506

Products & Services: Serology SARS-Cov-2 detection kits

Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka

Authors: Chandima Jeewandara, Dinuka Guruge, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Inoka Sepali Aberathna, Shyrar Tanussiya Ramu, Banuri Gunasekera, Ayesha Wijesinghe, Osanda Dissanayake, Heshan Kuruppu, Thushali Ranasinghe, Deshni Jayathilaka, Shashika Dayarathna, Dinithi Ekanayake, Jeewantha Jayamali, Nayanathara Gamalath, Anushika Mudunkotiwa, Gayasha Somathilake, Madhushika Dissanayake, Michael Harvie, Thashmi Nimasha, Deshan Madusanka, Tibutius Jayadas, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: J Immunol

PubMed ID: 34750205

Doi: 10.4049/jimmunol.2100762

Products & Services: Recombinant Antibody Expression

α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-β-catenin pathway

Authors: Zewu Zhu, Shuhao Ruan, Yingcheng Jiang, Fang Huang, Weiping Xia, Jinbo Chen, Yu Cui, Cheng He, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen

Journal: Cell Mol Life Sci

PubMed ID: 34724098

Doi: 10.1007/s00018-021-03972-x

Products & Services: Protein and Antibody Isolation

Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation

Authors: Thaiesha A Wright, Monica Sharfin Rahman, Camaryn Bennett, Madolynn R Johnson, Henry Fischesser, Natasha Ram, Amoni Tyler, Richard C Page, Dominik Konkolewicz

Journal: Bioconjug Chem

PubMed ID: 34730954

Doi: 10.1021/acs.bioconjchem.1c00487

Products & Services: Plasmid DNA Preparation