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High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population

Authors: Arshad A Pandith, Usma Manzoor, Ina Amin, Abida Ahmad, Masarat Rashid, Mahrukh H Zargar, Shayesta Rah, Fayaz A Dar, Iqbal Qasim, Dheera Sanadhya

Journal: Arch Gynecol Obstet

PubMed ID: 34542677

Doi: 10.1007/s00404-021-06235-z

Products & Services: Gene Synthesis

Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes

Authors: Thomas Steele, Anhao Sam, Shawna Evans, Elizabeth Browning, Sheryl Krig, Katelyn Macias, Adarsh Konda, Salma Siddiqui, Blythe Durbin-Johnson, Paramita Ghosh, Ruth Vinall

Journal: Cancers (Basel)

PubMed ID: 34503235

Doi: 10.3390/cancers13174425

Products & Services: Protein and Antibody Isolation

Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

Products & Services: Protein and Antibody Isolation

Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2

Authors: Jorge Hernández-Bello, José Javier Morales-Núñez, Andrea Carolina Machado-Sulbarán, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Paulina Balcázar-Félix, Jesús Alberto Gutiérrez-Brito, José Alvaro Lomelí-Nieto, José Francisco Muñoz-Valle

Journal: Vaccines (Basel)

PubMed ID: 34579284

Doi: 10.3390/vaccines9091047

A human antibody against human endothelin receptor type A that exhibits antitumor potency

Authors: Man-Seok Ju, Hye-Mi Ahn, Seong-Gu Han, Sanghwan Ko, Jung-Hyun Na, Migyeong Jo, Chung Su Lim, Byoung Joon Ko, Yeon Gyu Yu, Won-Kyu Lee, Youn-Jae Kim, Sang Taek Jung

Journal: Exp Mol Med

PubMed ID: 34588605

Doi: 10.1038/s12276-021-00678-9

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Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells

Authors: Guojie Chen, Kai Wang, Guoshu Li, Leidong Wang, Yangyang Xiao, Bo Chen

Journal: Oncol Res

PubMed ID: 34588094

Doi: 10.3727/096504021X16328213967104

Products & Services: Gene Synthesis

Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34582499

Doi: 10.1371/journal.pone.0258005

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Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice

Authors: Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Journal: Plant Biotechnol J

PubMed ID: 34582079

Doi: 10.1111/pbi.13716

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An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates

Authors: Stephen Geoffrey Holt, Sally Mahmoud, Wasim Ahmed, Juan Manuel Acuna, Ayman Kamal Al Madani, Islam Eltantawy, Walid Abbas Zaher, Gareth John Goodier, Nawal Ahmed Al Kaabi, Ali Abdulkareem Al Obaidli

Journal: Nephrology (Carlton)

PubMed ID: 34569677

Doi: 10.1111/nep.13980

Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios-Athanasios Dimopoulos

Journal: Br J Haematol

PubMed ID: 34528249

Doi: 10.1111/bjh.17841

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miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Authors: Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao

Journal: Mol Med Rep

PubMed ID: 34468015

Doi: 10.3892/mmr.2021.12392

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Design and Selection of Engineered Lytic Proteins With Decolonizing Activity

Authors: Diana Gutiérrez, Lorena Rodríguez-Rubio, Patricia Ruas-Madiedo, Lucía Fernández, Ana Belén Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar García, Ana Rodríguez

Journal: Front Microbiol

PubMed ID: 34594314

Doi: 10.3389/fmicb.2021.723834

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A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing

Authors: Bokyung Son, Jennifer Patterson-West, Melissa Arroyo-Mendoza, Revathy Ramachandran, James R Iben, Jingen Zhu, Venigalla Rao, Emilios K Dimitriadis, Deborah M Hinton

Journal: Nucleic Acids Res

PubMed ID: 34365505

Doi: 10.1093/nar/gkab678

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High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells

Authors: Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F Sikorski, Aleksander Czogalla

Journal: Membranes (Basel)

PubMed ID: 34564532

Doi: 10.3390/membranes11090715

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Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals

Authors: Anthony T Tan, Joey Me Lim, Nina Le Bert, Kamini Kunasegaran, Adeline Chia, Martin Dc Qui, Nicole Tan, Wan Ni Chia, Ruklanthi de Alwis, Ding Ying, Jean Xy Sim, Eng Eong Ooi, Lin-Fa Wang, Mark I-Cheng Chen, Barnaby E Young, Li Yang Hsu, Jenny Gh Low, David C Lye, Antonio Bertoletti

Journal: J Clin Invest

PubMed ID: 34623327

Doi: 10.1172/JCI152379

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Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

Authors: Dieter Waschbüsch, Kerryn Berndsen, Pawel Lis, Axel Knebel, Yuko Py Lam, Dario R Alessi, Amir R Khan

Journal: EMBO Rep

PubMed ID: 34580980

Doi: 10.15252/embr.202152675

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Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection

Authors: Chao Ye, Weiran Li, Ying Yang, Qingwen Liu, Sijing Li, Peng Zheng, Xiao Zheng, Ye Zhang, Jinrong He, Yongjun Chen, Liangqun Hua, Zhongqian Yang, Duo Li, Zhaoling Ren, Ying Yang, Jialong Qi, Weiwei Huang, Yanbing Ma

Journal: Cell Rep

PubMed ID: 34551309

Doi: 10.1016/j.celrep.2021.109750

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Production and Purification of Two Bioactive Antimicrobial Peptides Using a Two-Step Approach Involving an Elastin-Like Fusion Tag

Authors: Ana Margarida Pereira, André da Costa, Simoni Campos Dias, Margarida Casal, Raul Machado

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681180

Doi: 10.3390/ph14100956

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Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach

Authors: Jonathan Dauvé, Nicolas Belloy, Romain Rivet, Nicolas Etique, Pierre Nizet, Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Manuel Dauchez, Laurent Ramont, Stéphane Brézillon, Stéphanie Baud

Journal: Cancers (Basel)

PubMed ID: 34638415

Doi: 10.3390/cancers13194930

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Titanium Wear Particles Exacerbate -Induced Implant-Related Osteolysis and Decrease Efficacy of Antibiotic Therapy

Authors: Claudia Siverino, Linda Freitag, Daniel Arens, Ursula Styger, R Geoff Richards, T Fintan Moriarty, Vincent A Stadelmann, Keith Thompson

Journal: Microorganisms

PubMed ID: 34576840

Doi: 10.3390/microorganisms9091945

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Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Authors: Chelsie A Kadgien, Anusha Kamesh, Austen J Milnerwood

Journal: Mol Brain

PubMed ID: 34530877

Doi: 10.1186/s13041-021-00848-w

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Multiplex genome editing in using Mb3Cas12a

Authors: William T Jordan, Seth Currie, Robert J Schmitz

Journal: Plant Direct

PubMed ID: 34514290

Doi: 10.1002/pld3.344

Products & Services: ORF cDNA Clones/MolecularCloud

A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms

Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar

Journal: Int J Mol Sci

PubMed ID: 34638715

Doi: 10.3390/ijms221910374

Products & Services: Mutagenesis Services

SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Authors: Yiliang Wei, Yu-Han Huang, Damianos S Skopelitis, Shruti V Iyer, Ana S H Costa, Zhaolin Yang, Melissa Kramer, Emmalee R Adelman, Olaf Klingbeil, Osama E Demerdash, Sofya A Polyanskaya, Kenneth Chang, Sara Goodwin, Emily Hodges, W Richard McCombie, Maria E Figueroa, Christopher R Vakoc

Journal: Cancer Discov

PubMed ID: 34531253

Doi: 10.1158/2159-8290.CD-20-1849

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Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

Authors: Silvia Leon, Rajae Talbi, Elizabeth A McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S Carroll, Ursula B Kaiser, Carlos F Aylwin, Alejandro Lomniczi, Víctor M Navarro

Journal: Elife

PubMed ID: 34494548

Doi: 10.7554/eLife.69765

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Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

Authors: Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A N Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny

Journal: Nat Commun

PubMed ID: 34521831

Doi: 10.1038/s41467-021-25736-8

Products & Services: Gene Fragments

CriTER-A: A Novel Temperature-Dependent Noncoding RNA Switch in the Telomeric Transcriptome of

Authors: Cristina Romero-López, Alfredo Berzal-Herranz, José Luis Martínez-Guitarte, Mercedes de la Fuente

Journal: Int J Mol Sci

PubMed ID: 34638651

Doi: 10.3390/ijms221910310

Products & Services: Plasmid DNA Preparation

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

Authors: Mohammad Golam Sabbir, Carla G Taylor, Peter Zahradka

Journal: Cell Commun Signal

PubMed ID: 34563205

Doi: 10.1186/s12964-021-00778-z

Products & Services: ORF cDNA Clones/MolecularCloud

Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

Authors: Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal: J Immunother Cancer

PubMed ID: 34593618

Doi: 10.1136/jitc-2021-002569

Products & Services: Recombinant Antibody Expression

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Authors: Jaime L Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V Ozerov, Matthew T Walker, Kathleen Higgins, Mark W Lingen, Evgeny Izumchenko, Peter A Savage

Journal: Cell Rep Med

PubMed ID: 34622236

Doi: 10.1016/j.xcrm.2021.100399

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A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis

Authors: Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong

Journal: Cell Death Dis

PubMed ID: 34561424

Doi: 10.1038/s41419-021-04159-9

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Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses

Authors: Dylan R Zeiss, Paul A Steenkamp, Lizelle A Piater, Ian A Dubery

Journal: BMC Plant Biol

PubMed ID: 34548030

Doi: 10.1186/s12870-021-03200-5

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Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice

Authors: Qing Zeng, Qin Fang, Xincai Zhou, Hongfa Yang, Yang Dou, Wenhao Zhang, Pu Gong, Xianfang Rong

Journal: Front Mol Neurosci

PubMed ID: 34658785

Doi: 10.3389/fnmol.2021.728184

Products & Services: Recombinant Proteins

Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea

Authors: Qi Wu, Jizong Li, Wei Wang, Jinzhu Zhou, Dandan Wang, Baochao Fan, Xuehan Zhang, Dongbo Sun, Ga Gong, Sizhu Suolang, Bin Li

Journal: Viruses

PubMed ID: 34696337

Doi: 10.3390/v13101907

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Identification of Optimal Expression Parameters and Purification of a Codon-Optimized Human GLIS1 Transcription Factor from Escherichia coli

Authors: Chandrima Dey, Vishalini Venkatesan, Rajkumar P Thummer

Journal: Mol Biotechnol

PubMed ID: 34528219

Doi: 10.1007/s12033-021-00390-z

Products & Services: Codon Optimization

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu, Zheng Wang

Journal: Cancer Cell Int

PubMed ID: 34488769

Doi: 10.1186/s12935-021-02131-3

Products & Services: Protein and Antibody Isolation

Kinetic Characterization of a Putatively Chitin-Active LPMO Reveals a Preference for Soluble Substrates and Absence of Monooxygenase Activity

Authors: Lukas Rieder, Dejan Petrović, Priit Väljamäe, Vincent G H Eijsink, Morten Sørlie

Journal: ACS Catal

PubMed ID: 34567832

Doi: 10.1021/acscatal.1c03344

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Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation

Authors: Huan-Li Yang, Xiao-Wu Shi

Journal: Front Neurol

PubMed ID: 34557140

Doi: 10.3389/fneur.2021.659678

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Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based Antigen

Authors: Min Jiang, Gaiping Zhang, Hongliang Liu, Peiyang Ding, Yunchao Liu, Yuanyuan Tian, Yanwei Wang, Aiping Wang

Journal: Front Immunol

PubMed ID: 34621266

Doi: 10.3389/fimmu.2021.707977

Products & Services: Recombinant Proteins

Perturbation-specific responses by two neural circuits generating similar activity patterns

Authors: Daniel J Powell, Eve Marder, Michael P Nusbaum

Journal: Curr Biol

PubMed ID: 34506730

Doi: 10.1016/j.cub.2021.08.042

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A Molecular Survey of Bacterial Species in the Guts of Black Soldier Fly Larvae () Reared on Two Urban Organic Waste Streams in Kenya

Authors: Marwa Shumo, Fathiya M Khamis, Fidelis Levi Ombura, Chrysantus M Tanga, Komi K M Fiaboe, Sevgan Subramanian, Sunday Ekesi, Oliver K Schlüter, Arnold van Huis, Christian Borgemeister

Journal: Front Microbiol

PubMed ID: 34630342

Doi: 10.3389/fmicb.2021.687103

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SARS-CoV-2 Antibody Response to the BNT162b2 mRNA Vaccine in Persons with Past Natural Infection

Authors: Yu Min Kang, Kang-Won Choe, Ki-Deok Lee, Kwang Nam Kim, Moon Jung Kim, Jaegyun Lim

Journal: J Korean Med Sci

PubMed ID: 34490757

Doi: 10.3346/jkms.2021.36.e250

Angiogenesis and nerve regeneration induced by local administration of plasmid into the intact rat sciatic nerve

Authors: Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov

Journal: Neural Regen Res

PubMed ID: 33510097

Doi: 10.4103/1673-5374.306090

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Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Authors: Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Journal: Immunity

PubMed ID: 34525338

Doi: 10.1016/j.immuni.2021.08.022

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Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2

Authors: Yi-Sheng Sun, Jing-Jing Zhou, Han-Ping Zhu, Fang Xu, Wen-Bin Zhao, Hang-Jing Lu, Zhen Wang, Shu-Qing Chen, Ping-Ping Yao, Jian-Min Jiang, Zhan Zhou

Journal: Viruses

PubMed ID: 34696367

Doi: 10.3390/v13101936

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Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice

Authors: Donghui Zhang, Hong Zhu, Enbo Zhan, Fan Wang, Yue Liu, Wei Xu, Xian Liu, Jingjin Liu, Shufeng Li, Yong Pan, Yongshun Wang, Wei Cao

Journal: Front Cell Dev Biol

PubMed ID: 34631690

Doi: 10.3389/fcell.2021.647131

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Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

Authors: Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A Semenova, Avinash Chekuru, Paul Wirsching, Volker Kroehne, Saygın Bilican, Shady Sayed, Sylke Winkler, Sandra Spieß, Anja Machate, Jan Kaslin, Pertti Panula, Michael Brand

Journal: PLoS Genet

PubMed ID: 34516550

Doi: 10.1371/journal.pgen.1009794

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The evidence for and consequences of metabotropic glutamate receptor heterodimerization

Authors: Tyler W McCullock, Paul J Kammermeier

Journal: Neuropharmacology

PubMed ID: 34547332

Doi: 10.1016/j.neuropharm.2021.108801

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Tagging and Capturing of Lentiviral Vectors Using Short RNAs

Authors: Martin Panigaj, Michael P Marino, Jakob Reiser

Journal: Int J Mol Sci

PubMed ID: 34638603

Doi: 10.3390/ijms221910263

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RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

Authors: Xiaoyan Pan, Jian Shi, Xue Hu, Yan Wu, Liang Zeng, Yanfeng Yao, Weijuan Shang, Kunpeng Liu, Ge Gao, Weiwei Guo, Yun Peng, Shaohong Chen, Xiaoxiao Gao, Cheng Peng, Juhong Rao, Jiaxuan Zhao, Cheng Gong, Hui Zhou, Yudong Lu, Zili Wang, Xiliang Hu, WenJuan Cong, Lijuan Fang, Yongxiang Yan, Jing Zhang, Hui Xiong, Jizu Yi, Zhiming Yuan, Pengfei Zhou, Chao Shan, Gengfu Xiao

Journal: Cell Discov

PubMed ID: 34493710

Doi: 10.1038/s41421-021-00320-y

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Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Authors: Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Pahan

Journal: Nat Commun

PubMed ID: 34508096

Doi: 10.1038/s41467-021-25767-1

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Mass balance method for SI-traceable purity assignment of synthetic oxytocin

Authors: Sheng Wang, Peize Wu, Ming Li, Ting Huang, Naijie Shi, Liuxing Feng, Hongmei Li

Journal: J Pharm Biomed Anal

PubMed ID: 34656934

Doi: 10.1016/j.jpba.2021.114401

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Surface-enhanced Raman scattering-based detection of plasmin activity by specific peptide substrate

Authors: Nazife Nur Yazgan, Tugba Bulat, Ali Topcu, Fahriye Ceyda Dudak, Ismail Hakki Boyaci, Uğur Tamer

Journal: Food Chem

PubMed ID: 34624781

Doi: 10.1016/j.foodchem.2021.131235

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Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis

Authors: Dominique J Barbeau, Haley N Cartwright, Jessica R Harmon, Jessica R Spengler, Christina F Spiropoulou, John Sidney, Alessandro Sette, Anita K McElroy

Journal: J Virol

PubMed ID: 34495703

Doi: 10.1128/JVI.01506-21

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Optimised Heterologous Expression and Functional Analysis of the F1-Capsular Antigen Regulator Caf1R

Authors: Dharmender K Gahlot, Gyles Ifill, Sheila MacIntyre

Journal: Int J Mol Sci

PubMed ID: 34575967

Doi: 10.3390/ijms22189805

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Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter

Authors: Guifang Deng, Qiucheng Lei, Xuejin Gao, Yupeng Zhang, Huazhen Zheng, Jingcheng Bi, Xinying Wang

Journal: Front Nutr

PubMed ID: 34540875

Doi: 10.3389/fnut.2021.688715

Products & Services: Nucleic Acid Purification

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese

Journal: ACS Omega

PubMed ID: 34660952

Doi: 10.1021/acsomega.1c02083

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The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA

Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia

Journal: Molecules

PubMed ID: 34641320

Doi: 10.3390/molecules26195776

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Author Correction: Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins

Authors: Jongjin Park, Jiyoung Yoon, Daekee Kwon, Mi-Jung Han, Sunmee Choi, Slki Park, Junghyuk Lee, Kiwook Lee, Jaehwan Lee, Seunghee Lee, Kyung-Sun Kang, Sunghwa Choe

Journal: Sci Rep

PubMed ID: 34508163

Doi: 10.1038/s41598-021-98186-3

Products & Services: Mammalian Expression

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Authors: Viktor Mojr, Mohammad Roghanian, Hedvig Tamman, Duy Dinh Do Pham, Magdalena Petrová, Radek Pohl, Hiraku Takada, Katleen Van Nerom, Hanna Ainelo, Julien Caballero-Montes, Steffi Jimmy, Abel Garcia-Pino, Vasili Hauryliuk, Dominik Rejman

Journal: ACS Chem Biol

PubMed ID: 34477366

Doi: 10.1021/acschembio.1c00398

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Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Authors: Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens

Journal: Nat Commun

PubMed ID: 34471133

Doi: 10.1038/s41467-021-25572-w

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Multiple strategies for metabolic engineering of Escherichia coli for efficient production of glycolate

Authors: Tong Zhu, Die Yao, Di Li, Hongtao Xu, Shiru Jia, Changhao Bi, Jun Cai, Xinna Zhu, Xueli Zhang

Journal: Biotechnol Bioeng

PubMed ID: 34491579

Doi: 10.1002/bit.27934

Products & Services: Gene Fragments

Spectroscopic and functional characterization of the [2Fe-2S] scaffold protein Nfu from Synechocystis PCC6803

Authors: Zechariah Thompson, Insiya Fidai, Christine Wachnowsky, Amber L Hendricks, J A Cowan

Journal: Biochimie

PubMed ID: 34582998

Doi: 10.1016/j.biochi.2021.09.013

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Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identification of SARS-CoV-2 from clinical samples

Authors: Jiajie Liang, Peijun Teng, Wei Xiao, Guanbo He, Qifang Song, Ying Zhang, Bin Peng, Gan Li, Liangshan Hu, Donglin Cao, Yong Tang

Journal: J Nanobiotechnology

PubMed ID: 34496881

Doi: 10.1186/s12951-021-01021-0

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Authors: Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K Olsen, Tony T Huang

Journal: Cell Rep

PubMed ID: 34547223

Doi: 10.1016/j.celrep.2021.109754

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Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch

Authors: Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 34550864

Doi: 10.1080/10826068.2021.1977949

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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

Authors: Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami

Journal: Nat Commun

PubMed ID: 34518546

Doi: 10.1038/s41467-021-25679-0

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Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Authors: Jiawei Chen, Xinhai Cui, Aiwu Li, Guowei Li, Fengyin Sun

Journal: Urol Int

PubMed ID: 34569527

Doi: 10.1159/000518644

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NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

Authors: Bing Wang, Dmitri Svetlov, Irina Artsimovitch

Journal: Nucleic Acids Res

PubMed ID: 34352100

Doi: 10.1093/nar/gkab677

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A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress

Authors: Kaitlin Casanova-Hampton, Alexis Carey, Sarah Kassam, Alyssa Garner, George L Donati, Shankar Thangamani, Sargurunathan Subashchandrabose

Journal: Metallomics

PubMed ID: 34415046

Doi: 10.1093/mtomcs/mfab052

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De novo design of tyrosine and serine kinase-driven protein switches

Authors: Nicholas B Woodall, Zara Weinberg, Jesslyn Park, Florian Busch, Richard S Johnson, Mikayla J Feldbauer, Michael Murphy, Maggie Ahlrichs, Issa Yousif, Michael J MacCoss, Vicki H Wysocki, Hana El-Samad, David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 34518698

Doi: 10.1038/s41594-021-00649-8

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The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

Authors: Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizbé Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Strauss

Journal: ACS Chem Biol

PubMed ID: 34582681

Doi: 10.1021/acschembio.1c00535

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Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

Authors: Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson

Journal: BMC Vet Res

PubMed ID: 34579716

Doi: 10.1186/s12917-021-03030-5

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Molecular basis of human ATM kinase inhibition

Authors: K Stakyte, M Rotheneder, K Lammens, J D Bartho, U Grädler, T Fuchß, U Pehl, A Alt, E van de Logt, K P Hopfner

Journal: Nat Struct Mol Biol

PubMed ID: 34556870

Doi: 10.1038/s41594-021-00654-x

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Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple

Authors: Pengxiang Chen, Fang Zhi, Xuewei Li, Wenyun Shen, Mingjia Yan, Jieqiang He, Chana Bao, Tianle Fan, Shuangxi Zhou, Fengwang Ma, Qingmei Guan

Journal: Plant Physiol

PubMed ID: 34618120

Doi: 10.1093/plphys/kiab420

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Spectroscopic evidence of tetanus toxin translocation domain bilayer-induced refolding and insertion

Authors: Pierce T O'Neil, Victor Vasquez-Montes, Liskin Swint-Kruse, Michael R Baldwin, Alexey S Ladokhin

Journal: Biophys J

PubMed ID: 34555358

Doi: 10.1016/j.bpj.2021.09.030

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Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice

Authors: Xiaoling Cao, Yan Tian, Vi Nguyen, Yuping Zhang, Chao Gao, Rong Yin, Wayne Carver, Daping Fan, Helmut Albrecht, Taixing Cui, Wenbin Tan

Journal: FASEB J

PubMed ID: 34365657

Doi: 10.1096/fj.202002742RR

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Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing

Authors: Sarah A Schoonraad, Kristine M Fischenich, Kevin N Eckstein, Victor Crespo-Cuevas, Lea M Savard, Archish Muralidharan, Andrew A Tomaschke, Asais Camila Uzcategui, Mark A Randolph, Robert R McLeod, Virginia L Ferguson, Stephanie J Bryant

Journal: Biofabrication

PubMed ID: 34479218

Doi: 10.1088/1758-5090/ac23ab

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Serological Assays for Assessing Postvaccination SARS-CoV-2 Antibody Response

Authors: Sally A Mahmoud, Subhashini Ganesan, Shivaraj Naik, Safaa Bissar, Isra Al Zamel, K N Warren, Walid A Zaher, Gulfaraz Khan

Journal: Microbiol Spectr

PubMed ID: 34585943

Doi: 10.1128/Spectrum.00733-21

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Isotype-Specific Fc Effector Functions Enhance Antibody-Mediated Rift Valley Fever Virus Protection

Authors: Haley N Cartwright, Dominique J Barbeau, Anita K McElroy

Journal: mSphere

PubMed ID: 34494884

Doi: 10.1128/mSphere.00556-21

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Lysine Residues in the MK-Rich Region Are Not Required for Binding of the PbsP Protein From Group B Streptococci to Plasminogen

Authors: Francesco Coppolino, Letizia Romeo, Giampiero Pietrocola, Germana Lentini, Giuseppe Valerio De Gaetano, Giuseppe Teti, Roberta Galbo, Concetta Beninati

Journal: Front Cell Infect Microbiol

PubMed ID: 34568085

Doi: 10.3389/fcimb.2021.679792

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Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

Authors: Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C L Wong, Jianxun Qi, Wenjie Tan, George Fu Gao

Journal: MBio

PubMed ID: 34579576

Doi: 10.1128/mBio.02220-21

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Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation

Authors: Hongyi Zhou, Huabo Su, Weiqin Chen

Journal: Int J Mol Sci

PubMed ID: 34502418

Doi: 10.3390/ijms22179509

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A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Authors: Fei Wang, Zhimin Wan, Jinsen Wu, Yajuan Wang, Hui Fu, Hongxia Shao, Kun Qian, Wei Gao, Jianqiang, Aijian Qin

Journal: Frontiers in Microbiology

Doi: 10.3389/fmicb.2021.730449

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ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier

Authors: Xihua Yue , Yi Qian , Lianhui Zhu , Bopil Gim, Mengjing Bao , Jie Jia , Shuaiyang Jing , Yijing Wang , Chuanting Tan , Francesca Bottanelli , Pascal Ziltener , Sunkyu Choi , Piliang Hao , Intaek Lee

Journal: BMC Biol

PubMed ID: 34493279

Doi: 10.1186/s12915-021-01137-7

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PepVAE: Variational Autoencoder Framework for Antimicrobial Peptide Generation and Activity Prediction

Authors: Scott N Dean, Jerome Anthony E Alvarez, Dan Zabetakis, Scott A Walper, Anthony P Malanoski

Journal: Front Microbiol

PubMed ID: 34659152

Doi: 10.3389/fmicb.2021.725727

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The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Authors: Izzy Owen, Debra Yee, Hala Wyne, Theodora Myrto Perdikari, Victoria Johnson, Jeremy Smyth, Robert Kortum, Nicolas L Fawzi, Frank Shewmaker

Journal: J Cell Sci

PubMed ID: 34357401

Doi: 10.1242/jcs.258578

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Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

Authors: Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, G A Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson

Journal: Mol Cell

PubMed ID: 34437837

Doi: 10.1016/j.molcel.2021.07.041

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Genome-wide identification of the MADS-box transcription factor family in autotetraploid cultivated alfalfa (Medicago sativa L) and expression analysis under abiotic stress

Authors: Xueming Dong, Hao Deng, Wenxue Ma, Qiang Zhou, Zhipeng Liu

Journal: BMC Genomics

PubMed ID: 34362293

Doi: 10.1186/s12864-021-07911-9

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JA signal-mediated immunity of Dendrobium catenatum to necrotrophic Southern Blight pathogen

Authors: Cong Li, Qiuyi Shen, Xiang Cai, Danni Lai, Lingshang Wu, Zhigang Han, Tianlun Zhao, Donghong Chen, Jinping Si

Journal: BMC Plant Biol

PubMed ID: 34362300

Doi: 10.1186/s12870-021-03134-y

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The neutralizing antibody response post COVID-19 vaccination in patients with myeloma is highly dependent on the type of anti-myeloma treatment

Authors: Evangelos Terpos, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Panagiotis Malandrakis, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Maria Roussou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios A Dimopoulos

Journal: Blood Cancer J

PubMed ID: 34341335

Doi: 10.1038/s41408-021-00530-3

Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC

Authors: Sean P Fagan, Purba Mukherjee, William J Jaremko, Rachel Nelson-Rigg, Ryan C Wilson, Tyler L Dangerfield, Kenneth A Johnson, Indrajit Lahiri, Janice D Pata

Journal: Nucleic Acids Res

PubMed ID: 34302475

Doi: 10.1093/nar/gkab613

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A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization

Authors: Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Xuyu Zhou, Jie Ma

Journal: J Biol Chem

PubMed ID: 34450162

Doi: 10.1016/j.jbc.2021.101119

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Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand

Authors: Sarunporn Tandhavanant, Sirikamon Koosakunirand, Taniya Kaewarpai, Watcharapong Piyaphanee, Pornsawan Leaungwutiwong, Viravarn Luvira, Narisara Chantratita

Journal: PLoS ONE

PubMed ID: 34375345

Doi: 10.1371/journal.pone.0255796

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Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis

Authors: Qian-Nan Ren, Hong Zhang, Chao-Yue Sun, Yu-Feng Zhou, Xue-Feng Yang, Jian-Wu Long, Xiao-Xing Li, Shi-Juan Mai, Mei-Yin Zhang, Hui-Zhong Zhang, Hai-Qiang Mai, Min-Shan Chen, X F Steven Zheng, Hui-Yun Wang

Journal: Hepatology

PubMed ID: 34435708

Doi: 10.1002/hep.32120

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Expression of heat-resistant β-glucosidase in and its application in the production of gardenia blue

Authors: Wenxi Li, Jielin Li, Ying Xu, Yan Huang, Shuqi Xu, Zirui Ou, Xiaoli Long, Xinyu Li, Xinyu Liu, Zening Xiao, Jiaqi Huang, Weizhao Chen

Journal: Synth Syst Biotechnol

PubMed ID: 34504963

Doi: 10.1016/j.synbio.2021.08.002

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Profiling CD8 T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

Authors: Hang Zhang, Shasha Deng, Liting Ren, Peiyi Zheng, Xiaowen Hu, Tengchuan Jin, Xu Tan

Journal: Cell Rep

PubMed ID: 34506741

Doi: 10.1016/j.celrep.2021.109708

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SARS-CoV-2 neutralizing antibodies after first vaccination dose in breast cancer patients receiving CDK4/6 inhibitors

Authors: Flora Zagouri, Evangelos Terpos, Oraianthi Fiste, Michalis Liontos, Alexandros Briasoulis, Ioanna Katsiana, Efi Skafida, Christos Markellos, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Breast

PubMed ID: 34481366

Doi: 10.1016/j.breast.2021.08.017

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miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway

Authors: Qingping Song, Hui Liu, Chengyan Li, Haifeng Liang

Journal: Aging (Albany NY)

PubMed ID: 34426559

Doi: 10.18632/aging.203430

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