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Delayed KCNQ1/KCNE1 assembly on the cell surface helps I fulfil its function as a repolarization reserve in the heart

Authors: Zachary T Wilson, Min Jiang, Jing Geng, Sukhleen Kaur, Samuel W Workman, Jon Hao, Tytus Bernas, Gea-Ny Tseng

Journal: J Physiol

PubMed ID: 33963564

Doi: 10.1113/JP281773

Products & Services: Recombinant Proteins

Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density

Authors: Brittany N Araj, Bruce Swihart, Robert Morrison, Patricia Gonzales Hurtado, Andrew Teo, Almahamoudou Mahamar, Oumar Attaher, Bacary S Diarra, Santara Gaoussou, Djibrilla Issiaka, Alassane Dicko, Patrick E Duffy, Michal Fried

Journal: mSystems

PubMed ID: 34128693

Doi: 10.1128/mSystems.00347-21

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Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries

Authors: Sakkarapalayam M Mahalingam, Karson S Putt, Madduri Srinivasarao, Philip S Low

Journal: Molecules

PubMed ID: 34205289

Doi: 10.3390/molecules26123739

Products & Services: Proteins, Expression, Isolation and Analysis

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

Authors: Jiachen Huang, Pradeep Chopra, Lin Liu, Tamas Nagy, Jackelyn Murray, Ralph A Tripp, Geert-Jan Boons, Jarrod J Mousa

Journal: J Virol

PubMed ID: 34160259

Doi: 10.1128/JVI.00593-21

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SARS-CoV-2-specific CD8 T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Authors: Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi Ho Nguyen

Journal: Immunol Cell Biol

PubMed ID: 34086357

Doi: 10.1111/imcb.12482

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Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation

Authors: Naira Samarina, George Ssebyatika, Tanvi Tikla, Ja-Yun Waldmann, Bizunesh Abere, Vittoria Nanna, Michelangelo Marasco, Teresa Carlomagno, Thomas Krey, Thomas F Schulz

Journal: PLoS Pathog

PubMed ID: 34143834

Doi: 10.1371/journal.ppat.1009635

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Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaiti Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, Cameron Chow, Lauren Carter, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, David Baker

Journal: biorxiv

PubMed ID: 34189528

Doi: 10.1101/2021.06.22.449355

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Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

Authors: Hiroto Takeuchi, Satoru Konnai, Naoya Maekawa, Satoshi Takagi, Hiroshi Ohta, Noboru Sasaki, Sangho Kim, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Journal: Front Vet Sci

PubMed ID: 34195245

Doi: 10.3389/fvets.2021.656715

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The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Authors: Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin

Journal: Mol Cell Endocrinol

PubMed ID: 34126188

Doi: 10.1016/j.mce.2021.111366

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Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Authors: Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He

Journal: Mol Med Rep

PubMed ID: 34165172

Doi: 10.3892/mmr.2021.12231

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Serological survey of antibodies against SARS-CoV-2 in dogs and cats, Thailand

Authors: Kitikhun Udom, Waleemas Jairak, Ekkapat Chamsai, Kamonpan Charoenkul, Supanat Boonyapisitsopa, Napawan Bunpapong, Navapon Techakriengkrai, Alongkorn Amonsin

Journal: Transbound Emerg Dis

PubMed ID: 34180590

Doi: 10.1111/tbed.14208

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Design and in silico analysis of a whole-cell biosensor able to kill methicillin-resistant Staphylococcus aureus

Authors: Diego Francisco Benítez-Chao, Francisco de Jesús Balderas-Cisneros, Angel León-Buitimea, José Rubén Morones-Ramírez

Journal: Biotechnol Appl Biochem

PubMed ID: 34081352

Doi: 10.1002/bab.2210

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Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Authors: Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna

Journal: J Immunol

PubMed ID: 34162728

Doi: 10.4049/jimmunol.2001462

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients

Authors: Raquel Rubio-Acero, Noemi Castelletti, Volker Fingerle, Laura Olbrich, Abhishek Bakuli, Roman Wölfel, Philipp Girl, Katharina Müller, Simon Jochum, Matthias Strobl, Michael Hoelscher, Andreas Wieser

Journal: Infect Dis Ther

PubMed ID: 34155471

Doi: 10.1007/s40121-021-00475-x

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Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis

Authors: Jiajia Jiang, Rong Li, Junyi Wang, Jie Hou, Hui Qian, Wenrong Xu

Journal: Gastroenterol Res Pract

PubMed ID: 34221006

Doi: 10.1155/2021/5583029

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CRKL is a critical target of Hh-GLI2 pathway in lung adenocarcinoma

Authors: Xiaoming Liu, Yan Hu, Bentong Yu, Kai Peng, Xin Gan

Journal: J Cell Mol Med

PubMed ID: 34076957

Doi: 10.1111/jcmm.16592

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A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract

Authors: Qing Chen, Maaike de Vries, Kingsley Okechukwu Nwozor, Jacobien A Noordhoek, Corry-Anke Brandsma, H Marike Boezen, Irene H Heijink

Journal: Front Physiol

PubMed ID: 34163376

Doi: 10.3389/fphys.2021.690936

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A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis

Authors: Shiqiang Hou, Gengming Niu, Xin Liu, Pierre M Bourbon, Dongmei Zhang, Pengfei Cui, Kevin Zhao, Dezheng Zhao, Huiyan Zeng

Journal: Microvasc Res

PubMed ID: 34146582

Doi: 10.1016/j.mvr.2021.104209

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Secondary Structure of the Novel Myosin Binding Domain WYR and Implications within Myosin Structure

Authors: Lynda M Menard, Neil B Wood, Jim O Vigoreaux

Journal: Biology (Basel)

PubMed ID: 34209926

Doi: 10.3390/biology10070603

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Identification of ACE2 modifiers by CRISPR screening

Authors: Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer

Journal: biorxiv

PubMed ID: 34127970

Doi: 10.1101/2021.06.10.447768

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Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts

Authors: Yuanxin Li, Lixin Wang, Xueni Liu, Ying Huang, Xiaomei Li, Hong He, Xiaoyan Xu, Yujie Guo, Qi Li, Dan Zhu, Xingyu Wang, Haiyang Wang, Wenwen Li, Dan Li, Peng Xie

Journal: Neurochem Res

PubMed ID: 34165668

Doi: 10.1007/s11064-021-03385-z

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Large-Scale Oligonucleotide Synthesis for Whole-Genome Synthesis and Data Storage: Challenges and Opportunities

Authors: Li-Fu Song, Zheng-Hua Deng, Zi-Yi Gong, Lu-Lu Li, Bing-Zhi Li

Journal: Front Bioeng Biotechnol

PubMed ID: 34239862

Doi: 10.3389/fbioe.2021.689797

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Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases

Authors: Yiwen Zhang, Jiawei Yang, Siqi Yang, Jieze Zhang, Jun Chen, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang

Journal: CRISPR J

PubMed ID: 34152213

Doi: 10.1089/crispr.2021.0018

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Comparing Results of Five SARS-CoV-2 Antibody Assays Before and After the First Dose of ChAdOx1 nCoV-19 Vaccine among Health Care Workers

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34191577

Doi: 10.1128/JCM.01105-21

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Absence of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in stray cats

Authors: Angelica Stranieri, Stefania Lauzi, Alessia Giordano, Luigi Galimberti, Gabriele Ratti, Nicola Decaro, Federica Brioschi, Davide Lelli, Silvia Gabba, Ndiana Linda Amarachi, Eleonora Lorusso, Ana Moreno, Tiziana Trogu, Saverio Paltrinieri

Journal: Transbound Emerg Dis

PubMed ID: 34170624

Doi: 10.1111/tbed.14200

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Model infant biscuits release the opioid-acting peptides milk β-casomorphins and gluten exorphins after in vitro gastrointestinal digestion

Authors: Valentina Pica, Milda Stuknytė, Fabio Masotti, Ivano De Noni, Stefano Cattaneo

Journal: Food Chem

PubMed ID: 34118509

Doi: 10.1016/j.foodchem.2021.130262

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De novo biosynthesis of -arabinosylated flavones by utilization of rice -glycosyltransferases

Authors: Zhuo Chen, Yuwei Sun, Guangyi Wang, Ying Zhang, Qian Zhang, Yulian Zhang, Jianhua Li, Yong Wang

Journal: Bioresour Bioprocess

PubMed ID: 34150466

Doi: 10.1186/s40643-021-00404-3

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ptFVa ( Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C

Authors: Mark Schreuder, Xiaosong Liu, Ka Lei Cheung, Pieter H Reitsma, Gerry A F Nicolaes, Mettine H A Bos

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34162230

Doi: 10.1161/ATVBAHA.121.316038

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Evaluation of a Surrogate ELISA- Based Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) cPass Neutralization Antibody Detection Assay and Correlation with IgG Commercial Serology Assays

Authors: Vijayalakshmi Nandakumar, Tracie Profaizer, Bucky K Lozier, Marc G Elgort, Erin T Larragoite, Elizabeth S C P Williams, Antonio Solis-Leal, J Brandon Lopez, Bradford K Berges, Vicente Planelles, Jenna Rychert, Patricia R Slev, Julio C Delgado

Journal: Arch Pathol Lab Med

PubMed ID: 34181714

Doi: 10.5858/arpa.2021-0213-SA

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Evaluating a new mixed-mode resin Diamond MMC Mustang using Capto MMC ImpRes as a benchmark

Authors: Shengwei Zhang, Yan Wan, Jiwei Duan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 34147604

Doi: 10.1016/j.pep.2021.105930

Products & Services: Nucleic Acid Purification & Analysis

Focused peptide library screening as a route to a superior affinity ligand for antibody purification

Authors: Krištof Bozovičar, Barbara Jenko Bizjan, Anže Meden, Jernej Kovač, Tomaž Bratkovič

Journal: Sci Rep

PubMed ID: 34079028

Doi: 10.1038/s41598-021-91208-0

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Metaproteomic Discovery and Characterization of a Novel Lipolytic Enzyme From an Indian Hot Spring

Authors: Dennis Sander, Yanfei Yu, Premankur Sukul, Sina Schäkermann, Julia E Bandow, Trinetra Mukherjee, Subhra Kanti Mukhopadhyay, Lars I Leichert

Journal: Front Microbiol

PubMed ID: 34149658

Doi: 10.3389/fmicb.2021.672727

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The three-way junction structure of the HIV-1 PBS-segment binds host enzyme important for viral infectivity

Authors: Zhenwei Song, Thomas Gremminger, Gatikrushna Singh, Yi Cheng, Jun Li, Liming Qiu, Juan Ji, Margaret J Lange, Xiaobing Zuo, Shi-Jie Chen, Xiaoqin Zou, Kathleen Boris-Lawrie, Xiao Heng

Journal: Nucleic Acids Res

PubMed ID: 33978756

Doi: 10.1093/nar/gkab342

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The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Authors: Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P Casimiro, Cláudia G Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A Cardoso, André Macedo, Malwina Kotowicz, Facundo H Prado Spalm, Marcos J Dibo, Raquel D Monfardini, Tatiana T Torres, César S Mendes, Andres Garelli, Alisson M Gontijo

Journal: Nat Commun

PubMed ID: 34099654

Doi: 10.1038/s41467-021-23218-5

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Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin

Authors: Gabriela Garcia-Rodriguez, Yana Girardin, Alexander N Volkov, Ranjan Kumar Singh, Gopinath Muruganandam, Jeroen Van Dyck, Frank Sobott, Wim Versées, Daniel Charlier, Remy Loris

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 34196617

Doi: 10.1107/S2059798321004873

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Norovirus VPg Binds RNA through a Conserved N-Terminal K/R Basic Patch

Authors: Alice M McSweeney, Vivienne L Young, Vernon K Ward

Journal: Viruses

PubMed ID: 34209211

Doi: 10.3390/v13071282

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Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Authors: Victoria Cochran Xie, Jinyue Pu, Brian Ph Metzger, Joseph W Thornton, Bryan C Dickinson

Journal: Elife

PubMed ID: 34061027

Doi: 10.7554/eLife.67336

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Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models

Authors: Ayan Dey, T M Chozhavel Rajanathan, Harish Chandra, Hari P R Pericherla, Sanjeev Kumar, Huzaifa S Choonia, Mayank Bajpai, Arun K Singh, Anuradha Sinha, Gurwinder Saini, Parth Dalal, Sarosh Vandriwala, Mohammed A Raheem, Rupesh D Divate, Neelam L Navlani, Vibhuti Sharma, Aashini Parikh, Siva Prasath, M Sankar Rao, Kapil Maithal

Journal: Vaccine

PubMed ID: 34120764

Doi: 10.1016/j.vaccine.2021.05.098

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Upregulated Tie2 expression in plasma: a potential non-invasive biomarker for the diagnosis of breast cancer

Authors: Qingzhu Song, Fenglan Zhang, Tian Yuan, Yulong Wei

Journal: Eur Cytokine Netw

PubMed ID: 34240713

Doi: 10.1684/ecn.2021.0468

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Pro-resolving lipid mediator lipoxin A attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Authors: Claudio Derada Troletti, Gaby Enzmann, Valerio Chiurchiù, Alwin Kamermans, Silvia Martina Tietz, Paul C Norris, Neda Haghayegh Jahromi, Alessandro Leuti, Susanne M A van der Pol, Marijn Schouten, Charles N Serhan, Helga E de Vries, Britta Engelhardt, Gijs Kooij

Journal: Cell Rep

PubMed ID: 34077725

Doi: 10.1016/j.celrep.2021.109201

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The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide

Authors: Juan Pablo Robles, Magdalena Zamora, Lourdes Siqueiros-Marquez, Elva Adan-Castro, Gabriela Ramirez-Hernandez, Francisco Freinet Nuñez, Fernando Lopez-Casillas, Robert P Millar, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp

Journal: Angiogenesis

PubMed ID: 34097181

Doi: 10.1007/s10456-021-09800-x

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Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Authors: Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu, Zhi Yang, Zhaofei Liu

Journal: J Nanobiotechnology

PubMed ID: 34112200

Doi: 10.1186/s12951-021-00924-2

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The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides

Authors: Liran Komov, Dganit Melamed Kadosh, Eilon Barnea, Arie Admon

Journal: Mol Cell Proteomics

PubMed ID: 34087483

Doi: 10.1016/j.mcpro.2021.100105

Products & Services: Proteins, Expression, Isolation and Analysis

Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosis

Authors: Xue-Lin Lin, Zhao-Yun Zheng, Qing-Shan Zhang, Zhen Zhang, You-Zhi An

Journal: J Orthop Surg Res

PubMed ID: 34183039

Doi: 10.1186/s13018-021-02538-8

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LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage

Authors: Vinod Tiwari, Tomasz Kulikowicz, David M Wilson, Vilhelm A Bohr

Journal: Nucleic Acids Res

PubMed ID: 34096589

Doi: 10.1093/nar/gkab458

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Temporal induction of Lhx8 by optogenetic control system for efficient bone regeneration

Authors: Delan Huang, Runze Li, Jianhan Ren, Haotian Luo, Weicai Wang, Chen Zhou

Journal: Stem Cell Res Ther

PubMed ID: 34112263

Doi: 10.1186/s13287-021-02412-8

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Targeted Radionuclide Therapy Using Auger Electron Emitters: The Quest for the Right Vector and the Right Radionuclide

Authors: Malick Bio Idrissou, Alexandre Pichard, Bryan Tee, Tibor Kibedi, Sophie Poty, Jean-Pierre Pouget

Journal: Pharmaceutics

PubMed ID: 34209637

Doi: 10.3390/pharmaceutics13070980

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A Novel Plasmid DNA-Based Foot and Mouth Disease Virus Minigenome for Intracytoplasmic mRNA Production

Authors: Ploypailin Semkum, Challika Kaewborisuth, Nattarat Thangthamniyom, Sirin Theerawatanasirikul, Chalermpol Lekcharoensuk, Payuda Hansoongnern, Pongrama Ramasoota, Porntippa Lekcharoensuk

Journal: Viruses

PubMed ID: 34205958

Doi: 10.3390/v13061047

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Proteoform Differentiation using Tandem Trapped Ion Mobility, Electron Capture Dissociation, and ToF Mass Spectrometry

Authors: Kevin Jeanne Dit Fouque, Desmond Kaplan, Valery G Voinov, Frederik H V Holck, Ole N Jensen, Francisco Fernandez-Lima

Journal: Anal Chem

PubMed ID: 34170114

Doi: 10.1021/acs.analchem.1c01735

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Function is more reliable than quantity to follow up the humoral response to the Receptor Binding Domain of SARS- CoV-2 Spike protein after natural infection or COVID-19 vaccination

Authors: Carlos A Sariol, Petraleigh Pantoja, Crisanta Serrano-Collazo, Tiffany Rosa-Arocho, Albersy Armina, Lorna Cruz, E Taylor Stone, Teresa Arana, Consuelo Climent, Gerardo Latoni, Dianne Atehortua, Christina Pabon-Carrero, Amelia K Pinto, James D Brien, Ana M Espino

Journal: medrxiv

PubMed ID: 34100029

Doi: 10.1101/2021.06.02.21257975

Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans

Authors: Shai Abehsera, Shmuel Bentov, Xuguang Li, Simy Weil, Rivka Manor, Shahar Sagi, Shihao Li, Fuhua Li, Isam Khalaila, Eliahu D Aflalo, Amir Sagi

Journal: Sci Rep

PubMed ID: 34083647

Doi: 10.1038/s41598-021-91155-w

Products & Services: Proteins, Expression, Isolation and Analysis

The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ

Authors: Denis A Kiktev, Margaret Dominska, Tony Zhang, Joseph Dahl, Elena I Stepchenkova, Piotr Mieczkowski, Peter M Burgers, Scott Lujan, Adam Burkholder, Thomas A Kunkel, Thomas D Petes

Journal: Nucleic Acids Res

PubMed ID: 34019669

Doi: 10.1093/nar/gkab371

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Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in

Authors: Mariangela Dionysopoulou, George Diallinas

Journal: J Fungi (Basel)

PubMed ID: 34203131

Doi: 10.3390/jof7070514

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Impact of CRISPR-Cas9-Based Genome Engineering in Farm Animals

Authors: Parul Singh, Syed Azmal Ali

Journal: Vet Sci

PubMed ID: 34209174

Doi: 10.3390/vetsci8070122

"Resurrected" human-source urate oxidase with high uricolytic activity and stability

Authors: Nan Jiang, Chunqin Xu, Linhan Zhang, Jianhua Chen

Journal: Enzyme Microb Technol

PubMed ID: 34311889

Doi: 10.1016/j.enzmictec.2021.109852

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"Resurrected" human-source urate oxidase with high uricolytic activity and stability

Authors: Nan Jiang, Chunqin Xu, Linhan Zhang, Jianhua Chen

Journal: Enzyme Microb Technol

PubMed ID: 34311889

Doi: 10.1016/j.enzmictec.2021.109852

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Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

Authors: Daniel Ellis, Natalie Brunette, Katharine H D Crawford, Alexandra C Walls, Minh N Pham, Chengbo Chen, Karla-Luise Herpoldt, Brooke Fiala, Michael Murphy, Deleah Pettie, John C Kraft, Keara D Malone, Mary Jane Navarro, Cassandra Ogohara, Elizabeth Kepl, Rashmi Ravichandran, Claire Sydeman, Maggie Ahlrichs, Max Johnson, Alyssa Blackstone, Lauren Carter, Tyler N Starr, Allison J Greaney, Kelly K Lee, David Veesler, Jesse D Bloom, Neil P King

Journal: Front Immunol

PubMed ID: 34267764

Doi: 10.3389/fimmu.2021.710263

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SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Authors: Clemens Gutmann, Kaloyan Takov, Sean A Burnap, Bhawana Singh, Hashim Ali, Konstantinos Theofilatos, Ella Reed, Maria Hasman, Adam Nabeebaccus, Matthew Fish, Mark Jw McPhail, Kevin O'Gallagher, Lukas E Schmidt, Christian Cassel, Marieke Rienks, Xiaoke Yin, Georg Auzinger, Salvatore Napoli, Salma F Mujib, Francesca Trovato, Barnaby Sanderson, Blair Merrick, Umar Niazi, Mansoor Saqi, Konstantina Dimitrakopoulou, Rafael Fernández-Leiro, Silke Braun, Romy Kronstein-Wiedemann, Katie J Doores, Jonathan D Edgeworth, Ajay M Shah, Stefan R Bornstein, Torsten Tonn, Adrian C Hayday, Mauro Giacca, Manu Shankar-Hari, Manuel Mayr

Journal: Nat Commun

PubMed ID: 34099652

Doi: 10.1038/s41467-021-23494-1

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WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

Authors: Man Wu, Xueqing Xia, Jiemiao Hu, Natalie Wall Fowlkes, Shulin Li

Journal: Nat Commun

PubMed ID: 34108491

Doi: 10.1038/s41467-021-23864-9

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Mutation-induced dimerization of transforming growth factor-β-induced protein (TGFBIp) may drive protein aggregation in granular corneal dystrophy

Authors: Nadia Sukusu Nielsen, Trine A F Gadeberg, Ebbe Toftgaard Poulsen, Seandean Lykke Harwood, Christian E Weberskov, Jan Skov Pedersen, Gregers R Andersen, Jan J Enghild

Journal: J Biol Chem

PubMed ID: 34097874

Doi: 10.1016/j.jbc.2021.100858

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Synchrotron Radiation-Fourier Transformed Infrared microspectroscopy (μSR-FTIR) reveals multiple metabolism alterations in microalgae induced by cadmium and mercury

Authors: Ángel Barón-Sola, Margarita Toledo-Basantes, María Arana-Gandía, Flor Martínez, Cristina Ortega-Villasante, Tanja Dučić, Ibraheem Yousef, Luis E Hernández

Journal: J Hazard Mater

PubMed ID: 34214848

Doi: 10.1016/j.jhazmat.2021.126502

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of Heterologous Biosynthetic Pathways for Methanol-Based 5-Aminovalerate Production by Thermophilic

Authors: Luciana Fernandes Brito, Marta Irla, Ingemar Nærdal, Simone Balzer Le, Baudoin Delépine, Stéphanie Heux, Trygve Brautaset

Journal: Front Bioeng Biotechnol

PubMed ID: 34262896

Doi: 10.3389/fbioe.2021.686319

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SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

Authors: Jae Hyung Jung, Min-Seok Rha, Moa Sa, Hee Kyoung Choi, Ji Hoon Jeon, Hyeri Seok, Dae Won Park, Su-Hyung Park, Hye Won Jeong, Won Suk Choi, Eui-Cheol Shin

Journal: Nat Commun

PubMed ID: 34193870

Doi: 10.1038/s41467-021-24377-1

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Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring

Authors: Junfeng Chen, Huijuan Bi, Mats E Pettersson, Daiki X Sato, Angela P Fuentes-Pardo, Chunheng Mo, Shady Younis, Ola Wallerman, Patric Jern, Gregorio Molés, Ana Gómez, Gunnar Kleinau, Patrick Scheerer, Leif Andersson

Journal: Commun Biol

PubMed ID: 34172814

Doi: 10.1038/s42003-021-02307-7

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Comparative Molecular Characterization of Novel and Known Piscine Toti-Like Viruses

Authors: Liv Sandlund, Sunil K Mor, Vikash K Singh, Soumesh K Padhi, Nicholas B D Phelps, Stian Nylund, Aase B Mikalsen

Journal: Viruses

PubMed ID: 34205093

Doi: 10.3390/v13061063

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Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Authors: Euphemia Leung, Jinal Patel, Jennifer A Hollywood, Ayesha Zafar, Petr Tomek, David Barker, Lisa I Pilkington, Michelle van Rensburg, Ries J Langley, Nuala A Helsby, Christopher J Squire, Bruce C Baguley, William A Denny, Jóhannes Reynisson, Ivanhoe K H Leung

Journal: Oncol Ther

PubMed ID: 34159519

Doi: 10.1007/s40487-021-00158-0

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Tanshinones induce tumor cell apoptosis via directly targeting FHIT

Authors: Xianglian Zhou, Yuting Pan, Yue Wang, Bojun Wang, Yu Yan, Yi Qu, Xisong Ke

Journal: Sci Rep

PubMed ID: 34108553

Doi: 10.1038/s41598-021-91708-z

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Authors: Songtao Fan, Zhihong Zhang, Yadong Zhong, Chang Li, Xiaojun Huang, Fang Geng, Shaoping Nie

Journal: Food Funct

PubMed ID: 34180493

Doi: 10.1039/d1fo00410g

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Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Authors: Bingxiang Wang, Yishi Shen, Lei Zhai, Xiaodan Xia, Hong-Mei Gu, Maggie Wang, Yongfang Zhao, Xiaole Chang, Adekunle Alabi, Sijie Xing, Shijun Deng, Boyan Liu, Guiqing Wang, Shucun Qin, Da-Wei Zhang

Journal: J Lipid Res

PubMed ID: 34118252

Doi: 10.1016/j.jlr.2021.100091

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Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling

Authors: Pirooz Zareie, Christopher Szeto, Carine Farenc, Sachith D Gunasinghe, Elizabeth M Kolawole, Angela Nguyen, Chantelle Blyth, Xavier Y X Sng, Jasmine Li, Claerwen M Jones, Alex J Fulcher, Jesica R Jacobs, Qianru Wei, Lukasz Wojciech, Jan Petersen, Nicholas R J Gascoigne, Brian D Evavold, Katharina Gaus, Stephanie Gras, Jamie Rossjohn, Nicole L La Gruta

Journal: Science

PubMed ID: 34083463

Doi: 10.1126/science.abe9124

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Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions

Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki

Journal: PLoS ONE

PubMed ID: 34138966

Doi: 10.1371/journal.pone.0253489

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Double-faced role of Bcl-2-associated athanogene 7 in plant-Phytophthora interaction

Authors: Yang Zhou, Kun Yang, Ming Cheng, Yang Cheng, Yurong Li, Gan Ai, Tian Bai, Ruofei Xu, Weiwei Duan, Hao Peng, Xiaobo Li, Ai Xia, Yuanchao Wang, Maofeng Jing, Daolong Dou, Marty B Dickman

Journal: J Exp Bot

PubMed ID: 34195821

Doi: 10.1093/jxb/erab252

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Impact of copper treatment on phenylpropanoid biosynthesis in adventitious root culture of L

Authors: Yun Ji Park, Nam Su Kim, Ramaraj Sathasivam, Yong Suk Chung, Sang Un Park

Journal: Prep Biochem Biotechnol

PubMed ID: 34154516

Doi: 10.1080/10826068.2021.1934697

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A Covalently Crosslinked Ink for Multimaterials Drop-on-Demand 3D Bioprinting of 3D Cell Cultures

Authors: Robert H Utama, Vincent T G Tan, Kristel C Tjandra, Andrew Sexton, Duyen H T Nguyen, Aidan P O'Mahony, Eric Y Du, Peilin Tian, Julio C C Ribeiro, Maria Kavallaris, J Justin Gooding

Journal: Macromol Biosci

PubMed ID: 34173320

Doi: 10.1002/mabi.202100125

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Nanoparticle-based fluorescence probe for detection of NF-κB transcription factor in single cell via steric hindrance

Authors: Yuedi Ding, Zhenqiang Fan, Bo Yao, Dong Xu, Minhao Xie, Kai Zhang

Journal: Mikrochim Acta

PubMed ID: 34106343

Doi: 10.1007/s00604-021-04878-y

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MMP2 and TLRs modulate immune responses in the tumor microenvironment

Authors: Luciana R Muniz-Bongers, Christopher B McClain, Mansi Saxena, Gerold Bongers, Miriam Merad, Nina Bhardwaj

Journal: JCI Insight

PubMed ID: 34032639

Doi: 10.1172/jci.insight.144913

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Rational selection of hidden epitopes for a molecularly imprinted electrochemical sensor in the recognition of heat-denatured dengue NS1 protein

Authors: Matheus Siqueira Silva, Ana Patricia Moreira Tavares, Luiz Felipe Leomil Coelho, Lígia Ely Morganti Ferreira Dias, Rosa Maria Chura-Chambi, Flávio Guimarães da Fonseca, Maria Goreti Ferreira Sales, Eduardo Costa Figueiredo

Journal: Biosens Bioelectron

PubMed ID: 34144470

Doi: 10.1016/j.bios.2021.113419

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Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis

Authors: Huyen Thi La, Dao Bich Thi Tran, Hai Manh Tran, Linh Trong Nguyen

Journal: J Immunol Res

PubMed ID: 34189144

Doi: 10.1155/2021/5575260

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Biochemical characterization of a recombinant acid phosphatase from Acinetobacter baumannii

Authors: Elizabeth Smiley-Moreno, Douglas Smith, Jieh-Juen Yu, Phuong Cao, Bernard P Arulanandam, James P Chambers

Journal: PLoS ONE

PubMed ID: 34077475

Doi: 10.1371/journal.pone.0252377

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Anti-Spike Protein Assays to Determine SARS-CoV-2 Antibody Levels: a Head-to-Head Comparison of Five Quantitative Assays

Authors: Thomas Perkmann, Nicole Perkmann-Nagele, Thomas Koller, Patrick Mucher, Astrid Radakovics, Rodrig Marculescu, Michael Wolzt, Oswald F Wagner, Christoph J Binder, Helmuth Haslacher

Journal: Microbiol Spectr

PubMed ID: 34190591

Doi: 10.1128/Spectrum.00247-21

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miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells

Authors: Kai Zhang, Yijian Zhang, Cheng Chen, Yuexing Yuan, Xiaotian Jiang, Xiangjiang Yuan, Yao Wang

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 34142698

Doi: 10.1093/abbs/gmab082

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Low-dose rAAV-mediated inhibition of VEGF can treat neovascular pathologies without inducing retinal vasculitis

Authors: Shun-Yun Cheng, Yongwen Luo, Anneliese Malachi, Jihye Ko, Qin Su, Jun Xie, Bo Tian, Haijiang Lin, Xiao Ke, Qiang Zheng, Phillip W L Tai, Guangping Gao, Claudio Punzo

Journal: Hum Gene Ther

PubMed ID: 34182803

Doi: 10.1089/hum.2021.132

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Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin

Authors: Ian A Durie, John V Dzimianski, Courtney M Daczkowski, Jack McGuire, Kay Faaberg, Scott D Pegan

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 34196620

Doi: 10.1107/S205979832100509X

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Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells

Authors: Yu Bai, Qiang Du, Le Zhang, Ling Li, Nana Wang, Bo Wu, Ping Li, Ling Li

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34163433

Doi: 10.3389/fendo.2021.635321

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An optimized and robust SARS-CoV-2 pseudovirus system for viral entry research

Authors: Peng Yang, Yang Yang, Yuming Wu, Cong Huang, Yanlei Ding, Xuejun Wang, Shengqi Wang

Journal: J Virol Methods

PubMed ID: 34182038

Doi: 10.1016/j.jviromet.2021.114221

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The lncRNA PVT1 regulates autophagy in regulatory T cells to suppress heart transplant rejection in mice by targeting miR-146a

Authors: Jian Lu, Xiaodong Wang, Baotong Zhang, Peiyuan Li, Xuezhi Du, Feng Qi

Journal: Cell Immunol

PubMed ID: 34214903

Doi: 10.1016/j.cellimm.2021.104400

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Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA

Authors: Hiroaki Suzuki, Masaaki Matsuoka

Journal: J Neurochem

PubMed ID: 34081786

Doi: 10.1111/jnc.15445

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PU1 Mimic Synthetic Peptides Selectively Bind with GATA-1 and Allow c-Jun PU1 Binding to Enhance Myelopoiesis

Authors: Pawan Kumar Raghav, Gurudutta Gangenahalli

Journal: Int J Nanomedicine

PubMed ID: 34113102

Doi: 10.2147/IJN.S303235

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Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems

Authors: Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella

Journal: Biomolecules

PubMed ID: 34205698

Doi: 10.3390/biom11060917

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Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma

Authors: Jiansheng Li, Dongzhi Li, Xianhua Zhang, Cuijuan Li, Fengjuan Zhu

Journal: Oncol Rep

PubMed ID: 34165171

Doi: 10.3892/or.2021.8116

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Production of Protocatechuic Acid from -Hydroxyphenyl (H) Units and Related Aromatic Compounds Using an Aspergillus niger Cell Factory

Authors: Ronnie J M Lubbers, Ronald P de Vries

Journal: MBio

PubMed ID: 34154420

Doi: 10.1128/mBio.00391-21

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Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity

Authors: Alexandra Vaisman, Krystian Łazowski, Martin A M Reijns, Erin Walsh, John P McDonald, Kristiniana C Moreno, Dominic R Quiros, Marlen Schmidt, Harald Kranz, Wei Yang, Karolina Makiela-Dzbenska, Roger Woodgate

Journal: Mol Microbiol

PubMed ID: 34181784

Doi: 10.1111/mmi.14779

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A methyl esterase 1 (PvMES1) promotes the salicylic acid pathway and enhances Fusarium wilt resistance in common beans

Authors: Renfeng Xue, Ming Feng, Jian Chen, Weide Ge, Matthew W Blair

Journal: Theor Appl Genet

PubMed ID: 34128089

Doi: 10.1007/s00122-021-03830-1

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Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection

Authors: Fouad S El-Mayet, Kelly S Harrison, Clinton Jones

Journal: Viruses

PubMed ID: 34203849

Doi: 10.3390/v13061148

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Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides

Authors: Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch

Journal: MBio

PubMed ID: 34154407

Doi: 10.1128/mBio.01423-21

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Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds

Authors: Harrie van Erp, Fiona M Bryant, Jose Martin-Moreno, Louise V Michaelson, Peter J Eastmond

Journal: Metab Eng

PubMed ID: 34091040

Doi: 10.1016/j.ymben.2021.05.009

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Oral Administration of Producing Interferon Type II, Enhances the Immune Response Against Bacterial Pathogens in Rainbow Trout

Authors: Alvaro Santibañez, Diego Paine, Mick Parra, Carlos Muñoz, Natalia Valdes, Claudia Zapata, Rodrigo Vargas, Alex Gonzalez, Mario Tello

Journal: Front Immunol

PubMed ID: 34248997

Doi: 10.3389/fimmu.2021.696803

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Order and disorder-An integrative structure of the full-length human growth hormone receptor

Authors: Noah Kassem, Raul Araya-Secchi, Katrine Bugge, Abigail Barclay, Helena Steinocher, Adree Khondker, Yong Wang, Aneta J Lenard, Jochen Bürck, Cagla Sahin, Anne S Ulrich, Michael Landreh, Martin Cramer Pedersen, Maikel C Rheinstädter, Per Amstrup Pedersen, Kresten Lindorff-Larsen, Lise Arleth, Birthe B Kragelund

Journal: Sci Adv

PubMed ID: 34193419

Doi: 10.1126/sciadv.abh3805

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Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

Authors: James Brett Case, Rita E Chen, Longxing Cao, Baoling Ying, Emma S Winkler, Max Johnson, Inna Goreshnik, Minh N Pham, Swathi Shrihari, Natasha M Kafai, Adam L Bailey, Xuping Xie, Pei-Yong Shi, Rashmi Ravichandran, Lauren Carter, Lance Stewart, David Baker, Michael S Diamond

Journal: Cell Host Microbe

PubMed ID: 34192518

Doi: 10.1016/j.chom.2021.06.008

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Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

Authors: Han C,Jang M,Kim MJ,Han MH,Lee KR,Hahn JS,Ahn J

Journal: Journal of applied microbiology

PubMed ID: 33190388

Doi: 10.1111/jam.14931

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