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Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

Authors: Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Niem-Redene, Szu-Yi Chou, Luc Buée, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf

Journal: Brain

PubMed ID: 34086871

Doi: 10.1093/brain/awab205

Products & Services: Polyclonal Antibody Services

MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT)

Authors: Baoyi Yang, Shitao Xia, Xiangmei Ye, Wei Jing, Beifeng Wu

Journal: Biochem Biophys Res Commun

PubMed ID: 34171541

Doi: 10.1016/j.bbrc.2021.05.099

Products & Services: Recombinant Proteins

Immune and experimental infection responses of dairy cows vaccinated with the combination of six Staphylococcus aureus proteins that are expressed during bovine intramammary infection and a triple adjuvant

Authors: Céline Ster, Marianne Allard, Julie Côté-Gravel, Simon Boulanger, Pierre Lacasse, François Malouin

Journal: Vet Immunol Immunopathol

PubMed ID: 34217108

Doi: 10.1016/j.vetimm.2021.110290

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Oral Delivery of Expressing Chicken NK-2 Peptide Protects Against Infection in Broiler Chickens

Authors: Samiru S Wickramasuriya, Inkyung Park, Youngsub Lee, Woo H Kim, Chris Przybyszewski, Cyril G Gay, Jolieke G van Oosterwijk, Hyun S Lillehoj

Journal: Front Vet Sci

PubMed ID: 34150899

Doi: 10.3389/fvets.2021.684818

Products & Services: Recombinant Proteins

Development and Validation of a Simoa Assay for Determination of Recombinant Batroxobin in Human Serum

Authors: Bian-Zhen Wang, Meng-Jia Wang, Min-Rui Wang, Lun Ou, Li-Hou Dong, Kelly Dong, Hai-Feng Song

Journal: Curr Med Sci

PubMed ID: 34169424

Doi: 10.1007/s11596-021-2382-6

Products & Services: Monoclonal Antibody Services

Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests

Authors: Carolina De Marco Verissimo, Carol O'Brien, Jesús López Corrales, Amber Dorey, Krystyna Cwiklinski, Richard Lalor, Jack M Doyle, Stephen Field, Claire Masterson, Eduardo Ribes Martinez, Gerry Hughes, Colm Bergin, Kieran Walshe, Bairbre McNicholas, John G Laffey, John P Dalton, Colm Kerr, Sean Doyle

Journal: Epidemiol Infect

PubMed ID: 34099081

Doi: 10.1017/S0950268821001308

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Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2

Authors: Joel Pinczewski, Rebecca C Obeng, Craig L Slingluff, Victor H Engelhard

Journal: Pathol Res Pract

PubMed ID: 34167064

Doi: 10.1016/j.prp.2021.153527

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Synthetic conjugate peptide Fba-Met6 (MP12) induces complement-mediated resistance against disseminated Candida albicans

Authors: Abby L Adams, Karen Eberle, Jonothan Rosario Colón, Evan Courville, Hong Xin

Journal: Vaccine

PubMed ID: 34127293

Doi: 10.1016/j.vaccine.2021.06.001

Products & Services: Mammalian Expression

Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma

Authors: Sarah Müller, Stefanie Mayer, Peter Möller, Thomas F E Barth, Ralf Marienfeld

Journal: Neoplasia

PubMed ID: 34102454

Doi: 10.1016/j.neo.2021.05.005

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Identification and validation of T-cell receptors targeting RAS hot-spot mutations in human cancers for use in cell-based immunotherapy

Authors: Noam Levin, Biman C Paria, Nolan R Vale, Rami Yoseph, Frank J Lowery, Maria R Parkhurst, Zhiya Yu, Maria Florentin, Gal Cafri, Jared J Gartner, Mackenzie L Shindorf, Lien T Ngo, Satyajit Ray, Sanghyun P Kim, Amy R Copeland, Paul F Robbins, Steven A Rosenberg

Journal: Clin Cancer Res

PubMed ID: 34168045

Doi: 10.1158/1078-0432.CCR-21-0849

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Identification of a protein unique to the genus Plasmodium that contains a WD40 repeat domain and extensive low-complexity sequence

Authors: Gladys T Cortés, Martha Margarita Gonzalez Beltran, Claudio J Gómez-Alegría, Mark F Wiser

Journal: Parasitol Res

PubMed ID: 34142223

Doi: 10.1007/s00436-021-07190-z

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CyDisCo production of functional recombinant SARS-CoV-2 spike receptor binding domain

Authors: Janani Prahlad, Lucas R Struble, William E Lutz, Savanna A Wallin, Surender Khurana, Andy Schnaubelt, Mara J Broadhurst, Kenneth W Bayles, Gloria E O Borgstahl

Journal: Protein Sci

PubMed ID: 34191362

Doi: 10.1002/pro.4152

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mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer

Authors: Ling Tian, Congcong Chen, Yanguan Guo, Fan Zhang, Jinye Mi, Qi Feng, Shengbin Lin, Naite Xi, Jiaxin Tian, Li Yu, Yan Chen, Mingrong Cao, Caiyong Lai, Jun Fan, Yongchang Zhang, Guo Chen

Journal: Neoplasia

PubMed ID: 34126361

Doi: 10.1016/j.neo.2021.05.007

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An updated RT-qPCR assay for the simultaneous detection and quantification of chikungunya, dengue and zika viruses

Authors: Diego Alejandro Álvarez-Díaz, Emmanuel Valencia-Álvarez, Jorge Alonso Rivera, Aura Caterine Rengifo, José Aldemar Usme-Ciro, Dioselina Peláez-Carvajal, Yenny Yolanda Lozano-Jiménez, Orlando Torres-Fernández

Journal: Infect Genet Evol

PubMed ID: 34116240

Doi: 10.1016/j.meegid.2021.104967

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Novel neuroprotective peptides in the venom of the solitary scoliid wasp

Authors: Carlos Alberto-Silva, Fernanda Calheta Vieira Portaro, Roberto Tadashi Kodama, Halyne Queiroz Pantaleão, Marisa Rangel, Ken-Ichi Nihei, Katsuhiro Konno

Journal: J Venom Anim Toxins Incl Trop Dis

PubMed ID: 34194483

Doi: 10.1590/1678-9199-JVATITD-2020-0171

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Improvement in extracellular secretion of recombinant L-asparaginase II by Escherichia coli BL21 (DE3) using glycine and n-dodecane

Authors: Juan Carlos Flores-Santos, Ignacio S Moguel, Gisele Monteiro, Adalberto Pessoa, Michele Vitolo

Journal: Braz J Microbiol

PubMed ID: 34100260

Doi: 10.1007/s42770-021-00534-y

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H, C, N backbone and side-chain NMR assignments of the C-terminal domain of Mycobacterium Tuberculosis ribosome maturation factor RimM

Authors: Haoran Zhang, Chenyun Guo, Donghai Lin

Journal: Biomol NMR Assign

PubMed ID: 34101143

Doi: 10.1007/s12104-021-10032-9

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Structural and biochemical characterization of a novel ZntB (CmaX) transporter protein from Pseudomonas aeruginosa

Authors: Artem Stetsenko, Pavlo Stehantsev, Natalia O Dranenko, Mikhail S Gelfand, Albert Guskov

Journal: Int J Biol Macromol

PubMed ID: 34175341

Doi: 10.1016/j.ijbiomac.2021.06.130

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Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis

Authors: Zhongfang Zhao, Nong Liao

Journal: Onco Targets Ther

PubMed ID: 34168462

Doi: 10.2147/OTT.S275322

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SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods

Authors: Elitza S Theel, Patrick W Johnson, Katie L Kunze, Liang Wu, Amy P Gorsh, Dane Granger, Matthew M Roforth, Calvin R Jerde, Michael Lasho, Kylie J Andersen, Brenna M Murphy, Julie Harring, Douglas F Lake, Sergei A Svarovsky, Jonathon W Senefeld, Rickey E Carter, Michael J Joyner, Nikola A Baumann, John R Mills

Journal: J Clin Microbiol

PubMed ID: 34166066

Doi: 10.1128/JCM.01231-21

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Phage vB_PaeS-PAJD-1 Rescues Murine Mastitis Infected With Multidrug-Resistant

Authors: Zhaofei Wang, Yibing Xue, Ya Gao, Mengting Guo, Yuanping Liu, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan

Journal: Front Cell Infect Microbiol

PubMed ID: 34178726

Doi: 10.3389/fcimb.2021.689770

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Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer

Authors: Claudia Enriquez, Valeria Cancila, Renata Ferri, Roberta Sulsenti, Irene Fischetti, Matteo Milani, Paola Ostano, Ilaria Gregnanin, Maurizia Mello-Grand, Enrico Berrino, Marco Bregni, Giuseppe Renne, Claudio Tripodo, Mario P Colombo, Elena Jachetti

Journal: Cancer Res

PubMed ID: 34185677

Doi: 10.1158/0008-5472.CAN-21-0163

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Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Invasive Infection

Authors: Jonothan Rosario-Colon, Karen Eberle, Abby Adams, Evan Courville, Hong Xin

Journal: Int J Mol Sci

PubMed ID: 34200478

Doi: 10.3390/ijms22116162

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Distinct responses of human peripheral blood cells to different misfolded protein oligomers

Authors: Magdalena Leal-Lasarte, Benedetta Mannini, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson, Cintia Roodveldt, David Pozo

Journal: Immunology

PubMed ID: 34043816

Doi: 10.1111/imm.13377

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Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib

Authors: Eric J Niesor, Guy Boivin, Eric Rhéaume, Rong Shi, Véronique Lavoie, Nathalie Goyette, Marie-Eve Picard, Anne Perez, Fouzia Laghrissi-Thode, Jean-Claude Tardif

Journal: ACS Omega

PubMed ID: 34235330

Doi: 10.1021/acsomega.1c01797

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of an Atypical Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

Authors: Adélle Burger, Paula Macucule-Tinga, Stephen John Bentley, Michael Hans Ludewig, Ndumiso Nhlakanipho Mhlongo, Addmore Shonhai, Aileen Boshoff

Journal: Int J Mol Sci

PubMed ID: 34202520

Doi: 10.3390/ijms22136776

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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Authors: Taylor R Jamieson, Joanna Poutou, Ricardo Marius, Xiaohong He, Reza Rezaei, Taha Azad, Carolina S Ilkow

Journal: J Vis Exp

PubMed ID: 34152313

Doi: 10.3791/62486

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Mini-Replicon-Based Reverse-Genetics System for Rice Stripe Tenuivirus

Authors: Mingfeng Feng, Luyao Li, Ruixiang Cheng, Yulong Yuan, Yongxin Dong, Minglong Chen, Rong Guo, Min Yao, Yi Xu, Yijun Zhou, Jianxiang Wu, Xin Shun Ding, Xueping Zhou, Xiaorong Tao

Journal: J Virol

PubMed ID: 33952642

Doi: 10.1128/JVI.00589-21

Products & Services: Codon Optimization

Identification of a dual orange/far-red and blue light photoreceptor from an oceanic green picoplankton

Authors: Yuko Makita, Shigekatsu Suzuki, Keiji Fushimi, Setsuko Shimada, Aya Suehisa, Manami Hirata, Tomoko Kuriyama, Yukio Kurihara, Hidefumi Hamasaki, Emiko Okubo-Kurihara, Kazutoshi Yoshitake, Tsuyoshi Watanabe, Masaaki Sakuta, Takashi Gojobori, Tomoko Sakami, Rei Narikawa, Haruyo Yamaguchi, Masanobu Kawachi, Minami Matsui

Journal: Nat Commun

PubMed ID: 34135337

Doi: 10.1038/s41467-021-23741-5

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miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3

Authors: Fengzhen Liu, Xia Zhang, You Peng, Liping Zhang, Yao Yu, Peng Hua, Peiying Zhu, Xinyu Yan, Yin Li, Liang Zhang

Journal: Cell Rep

PubMed ID: 34107258

Doi: 10.1016/j.celrep.2021.109225

Products & Services: ORF cDNA Clones/MolecularCloud

HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency

Authors: Helin Sertkaya, Mattia Ficarelli, Nathan P Sweeney, Hannah Parker, Conrad A Vink, Chad M Swanson

Journal: Sci Rep

PubMed ID: 34103612

Doi: 10.1038/s41598-021-91309-w

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Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

Authors: Sangsu Park, Minh Quan Nguyen, Huynh Kim Khanh Ta, Minh Tan Nguyen, Gunsup Lee, Chong Jai Kim, Yeon Jin Jang, Han Choe

Journal: Int J Mol Sci

PubMed ID: 34204265

Doi: 10.3390/ijms22126483

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Novel Bacterial Production of Two Different Bioactive Forms of Human Stem-Cell Factor

Authors: Eunyoung Lee, Michelle Novais de Paula, Sangki Baek, Huynh Kim Khanh Ta, Minh Tan Nguyen, Taeck-Hyun Jeong, Chong Jai Kim, Yeon Jin Jang, Han Choe

Journal: Int J Mol Sci

PubMed ID: 34198626

Doi: 10.3390/ijms22126361

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The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer

Authors: Katie A Thies, Matthew W Cole, Rachel E Schafer, Jonathan M Spehar, Dillon S Richardson, Sarah A Steck, Manjusri Das, Arthur W Lian, Alo Ray, Reena Shakya, Sue E Knoblaugh, Cynthia D Timmers, Michael C Ostrowski, Arnab Chakravarti, Gina M Sizemore, Steven T Sizemore

Journal: Breast Cancer Res

PubMed ID: 34118960

Doi: 10.1186/s13058-021-01438-3

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A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription

Authors: Juston C Weems, Brian D Slaughter, Jay R Unruh, Kyle J Weaver, Brandon D Miller, Kym M Delventhal, Joan W Conaway, Ronald C Conaway

Journal: J Biol Chem

PubMed ID: 34116057

Doi: 10.1016/j.jbc.2021.100862

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Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Authors: Maura Garofalo, Luca Piccoli, Margherita Romeo, Maria Monica Barzago, Sara Ravasio, Mathilde Foglierini, Milos Matkovic, Jacopo Sgrignani, Raoul De Gasparo, Marco Prunotto, Luca Varani, Luisa Diomede, Olivier Michielin, Antonio Lanzavecchia, Andrea Cavalli

Journal: Nat Commun

PubMed ID: 34112780

Doi: 10.1038/s41467-021-23880-9

Products & Services: Mammalian Expression

Prdx1 Interacts with ASK1 upon Exposure to HO and Independently of a Scaffolding Protein

Authors: Trung Nghia Vo, Julia Malo Pueyo, Khadija Wahni, Daria Ezeriņa, Jesalyn Bolduc, Joris Messens

Journal: Antioxidants (Basel)

PubMed ID: 34209102

Doi: 10.3390/antiox10071060

Products & Services: Mammalian Expression

Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1

Authors: Jin Chai, Yuanheng Cai, Changxu Pang, Liguo Wang, Sean McSweeney, John Shanklin, Qun Liu

Journal: Nat Commun

PubMed ID: 34103506

Doi: 10.1038/s41467-021-23533-x

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Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D

Authors: Youchao Deng, Sunbin Deng, Yi-Hsun Ho, Sarah M Gardner, Zhi Huang, Ronen Marmorstein, Rong Huang

Journal: J Med Chem

PubMed ID: 34110812

Doi: 10.1021/acs.jmedchem.1c00141

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The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status

Authors: Patricia Garcia-Garcia, Ricardo Reyes, José Antonio Rodriguez, Tomas Martín, Carmen Evora, Patricia Díaz-Rodríguez, Araceli Delgado

Journal: Pharmaceutics

PubMed ID: 34209593

Doi: 10.3390/pharmaceutics13070979

Products & Services: Recombinant Proteins

CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression

Authors: Yi Liu, Simin Chen, Gang Peng, Yiwei Liao, Xuegong Fan, Zuping Zhang, Chenfu Shen

Journal: Cancer Cell Int

PubMed ID: 34112159

Doi: 10.1186/s12935-021-02001-y

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ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion

Authors: Qiangmin Zhang, Julia Gefter, W Bruce Sneddon, Tatyana Mamonova, Peter A Friedman

Journal: iScience

PubMed ID: 34189428

Doi: 10.1016/j.isci.2021.102770

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A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge

Authors: Zachary R Sia, Xuedan He, Ali Zhang, Jann C Ang, Shuai Shao, Amal Seffouh, Wei-Chiao Huang, Michael R D'Agostino, Amir Teimouri Dereshgi, Sambhara Suryaprakash, Joaquin Ortega, Hanne Andersen, Matthew S Miller, Bruce A Davidson, Jonathan F Lovell

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34050027

Doi: 10.1073/pnas.2025759118

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Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence

Authors: Kirsi Savijoki, Henna Myllymäki, Hanna Luukinen, Lauri Paulamäki, Leena-Maija Vanha-Aho, Aleksandra Svorjova, Ilkka Miettinen, Adyary Fallarero, Teemu O Ihalainen, Jari Yli-Kauhaluoma, Tuula A Nyman, Mataleena Parikka

Journal: mSystems

PubMed ID: 34156290

Doi: 10.1128/mSystems.00500-21

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LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p

Authors: Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma, Xin Gao

Journal: BMC Cancer

PubMed ID: 34078310

Doi: 10.1186/s12885-021-08227-3

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Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins

Authors: Eriko Ohgitani, Masaharu Shin-Ya, Masaki Ichitani, Makoto Kobayashi, Takanobu Takihara, Masaya Kawamoto, Hitoshi Kinugasa, Osam Mazda

Journal: Molecules

PubMed ID: 34208050

Doi: 10.3390/molecules26123572

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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

Authors: Ebony N Gary, Bryce M Warner, Elizabeth M Parzych, Bryan D Griffin, Xizhou Zhu, Nikesh Tailor, Nicholas J Tursi, Mable Chan, Mansi Purwar, Robert Vendramelli, Jihae Choi, Kathy L Frost, Sophia Reeder, Kevin Liaw, Edgar Tello, Ali R Ali, Kun Yun, Yanlong Pei, Sylvia P Thomas, Amira D Rghei, Matthew M Guilleman, Kar Muthumani, Trevor Smith, Sarah K Wootton, Ami Patel, David B Weiner, Darwyn Kobasa

Journal: iScience

PubMed ID: 34124612

Doi: 10.1016/j.isci.2021.102699

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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Authors: Yiwen Zhang, Yingshi Chen, Yuzhuang Li, Feng Huang, Baohong Luo, Yaochang Yuan, Baijin Xia, Xiancai Ma, Tao Yang, Fei Yu, Jun Liu, Bingfeng Liu, Zheng Song, Jingliang Chen, Shumei Yan, Liyang Wu, Ting Pan, Xu Zhang, Rong Li, Wenjing Huang, Xin He, Fei Xiao, Junsong Zhang, Hui Zhang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34021074

Doi: 10.1073/pnas.2024202118

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Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers

Authors: Daiki Kashima, Masahiro Kawahara

Journal: Sci Rep

PubMed ID: 34083659

Doi: 10.1038/s41598-021-91287-z

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Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells

Authors: Ruoxi W Wang, Sonia Viganò, Uri Ben-David, Angelika Amon, Stefano Santaguida

Journal: EMBO Rep

PubMed ID: 34105235

Doi: 10.15252/embr.202052032

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The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA

Authors: Olga A Postnikova, Sheetal Uppal, Weiliang Huang, Maureen A Kane, Rafael Villasmil, Igor B Rogozin, Eugenia Poliakov, T Michael Redmond

Journal: Int J Mol Sci

PubMed ID: 34204305

Doi: 10.3390/ijms22126490

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Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

Authors: Claudia Vivori, Panagiotis Papasaikas, Ralph Stadhouders, Bruno Di Stefano, Anna Ribó Rubio, Clara Berenguer Balaguer, Serena Generoso, Anna Mallol, José Luis Sardina, Bernhard Payer, Thomas Graf, Juan Valcárcel

Journal: Genome Biol

PubMed ID: 34082786

Doi: 10.1186/s13059-021-02372-5

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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Authors: Maritza Puray-Chavez, Kyle M LaPak, Travis P Schrank, Jennifer L Elliott, Dhaval P Bhatt, Megan J Agajanian, Ria Jasuja, Dana Q Lawson, Keanu Davis, Paul W Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E Eschbach, Christian Shema Mugisha, Emily M Cousins, Erica W Cloer, Hung R Vuong, Laura A VanBlargan, Adam L Bailey, Pavlo Gilchuk, James E Crowe, Michael S Diamond, D Neil Hayes, Sean P J Whelan, Amjad Horani, Steven L Brody, Dennis Goldfarb, M Ben Major, Sebla B Kutluay

Journal: Cell Rep

PubMed ID: 34214467

Doi: 10.1016/j.celrep.2021.109364

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Effective Killing of Acute Myeloid Leukemia by TIM-3 Targeted Chimeric Antigen Receptor T Cells

Authors: Wen-Hsin Sandy Lee, Zhiyong Ye, Alice M S Cheung, Y P Sharon Goh, Hsueh Ling Janice Oh, Ravisankar Rajarethinam, Siok Ping Yeo, Mun Kuen Soh, Esther Hian Li Chan, Lip Kun Tan, Soo-Yong Tan, Charles Chuah, Wee Joo Chng, John E Connolly, Cheng-I Wang

Journal: Mol Cancer Ther

PubMed ID: 34158344

Doi: 10.1158/1535-7163.MCT-20-0155

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Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol

Authors: Sarah Mazzotta, Judith Berastegui-Cabrera, Margarita Vega-Holm, María Del Rosario García-Lozano, Marta Carretero-Ledesma, Francesca Aiello, José Manuel Vega-Pérez, Jerónimo Pachón, Fernando Iglesias-Guerra, Javier Sánchez-Céspedes

Journal: Bioorg Chem

PubMed ID: 34175724

Doi: 10.1016/j.bioorg.2021.105095

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In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

Authors: Daniel Pokorny, Linda Truebestein, Kaelin D Fleming, John E Burke, Thomas A Leonard

Journal: J Biol Chem

PubMed ID: 34181950

Doi: 10.1016/j.jbc.2021.100919

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A phase transition enhances the catalytic activity of SARM1, an NAD glycohydrolase involved in neurodegeneration

Authors: Heather S Loring, Victoria L Czech, Janneke D Icso, Lauren O'Connor, Sangram S Parelkar, Alexandra B Byrne, Paul R Thompson

Journal: Elife

PubMed ID: 34184985

Doi: 10.7554/eLife.66694

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Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Authors: Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Parant

Journal: Cell Death Dis

PubMed ID: 34193827

Doi: 10.1038/s41419-021-03902-6

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Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

Authors: Matthieu P M H Benoit, Ana B Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H Kwok, Hernando Sosa

Journal: Nat Commun

PubMed ID: 34131133

Doi: 10.1038/s41467-021-23581-3

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly principles and stoichiometry of a complete human kinetochore module

Authors: Kai Walstein, Arsen Petrovic, Dongqing Pan, Birte Hagemeier, Dorothee Vogt, Ingrid R Vetter, Andrea Musacchio

Journal: Sci Adv

PubMed ID: 34193424

Doi: 10.1126/sciadv.abg1037

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Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

Authors: Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F B Räder, William J Polacheck, Horst Kessler, Lydia Sorokin, Britta Trappmann

Journal: Nat Commun

PubMed ID: 34099677

Doi: 10.1038/s41467-021-23644-5

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Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota

Authors: Djalma S Lima-Junior, Siddharth R Krishnamurthy, Nicolas Bouladoux, Nicholas Collins, Seong-Ji Han, Erin Y Chen, Michael G Constantinides, Verena M Link, Ai Ing Lim, Michel Enamorado, Christophe Cataisson, Louis Gil, Indira Rao, Taylor K Farley, Galina Koroleva, Jan Attig, Stuart H Yuspa, Michael A Fischbach, George Kassiotis, Yasmine Belkaid

Journal: Cell

PubMed ID: 34166614

Doi: 10.1016/j.cell.2021.05.020

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Directed evolution of AAV accounting for long-term and enhanced transduction of cardiovascular endothelial cells

Authors: Y B Liu, B C Xu, Y T Chen, X Yuan, J Y Liu, T Liu, G Z Du, W Jiang, Y Yang, Y Zhu, L J Chen, B S Ding, Y Q Wei, L Yang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34485601

Doi: 10.1016/j.omtm.2021.05.015

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A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

Authors: Alexandra Tauzin, Manon Nayrac, Mehdi Benlarbi, Shang Yu Gong, Romain Gasser, Guillaume Beaudoin-Bussières, Nathalie Brassard, Annemarie Laumaea, Dani Vézina, Jérémie Prévost, Sai Priya Anand, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Guillaume Goyette, Julia Niessl, Olivier Tastet, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Leonidas Stamatatos, Andrew T McGuire, Catherine Larochelle, Pradeep Uchil, Maolin Lu, Walther Mothes, Gaston De Serres, Sandrine Moreira, Michel Roger, Jonathan Richard, Valérie Martel-Laferrière, Ralf Duerr, Cécile Tremblay, Daniel E Kaufmann, Andrés Finzi

Journal: Cell Host Microbe

PubMed ID: 34133950

Doi: 10.1016/j.chom.2021.06.001

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Absolute protein assay for the simultaneous quantification of two epoxide hydrolases in rats by mass spectrometry-based targeted proteomics

Authors: Ting Wu, Xiaoyun Xi, Ying Chen, Chao Jiang, Qian Zhang, Guoliang Dai, Yongtao Bai, Weidong Zhang, Ting Ni, Jiandong Zou, Wenzheng Ju, Meijuan Xu

Journal: J Sep Sci

PubMed ID: 34008891

Doi: 10.1002/jssc.202100066

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Sphingomonas sp. KT‑1 PahZ2 Structure Reveals a Role for Conformational Dynamics in Peptide Bond Hydrolysis

Authors: Chad A. BrambleyChad A. Brambley Department of Chemistry, Middle Tennessee State University, 1301 East Main Street, Murfreesboro, Tennessee 37132, United States More by Chad A. Brambley , Tarah J. Yared, Marriah Gonzalez, Amanda L. Jansch, Jamie R. Wallen, Mitch H. Weiland*, and Justin M. Miller*

Journal: The Journal of Physical Chemistry B

PubMed ID: 34060838

Doi: doi.org/10.1021/acs.jpcb.1c01216

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Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs

Authors: Stepan S. Denisov, Johannes H. Ippel, Elisabetta Castoldi, Ben J. Mans, Tilman M. Hackeng, and Ingrid Dijkgraaf

Journal: Journal of Biological Chemistry

PubMed ID: 34118237

Doi: 10.1016/j.jbc.2021.100865

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Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

Authors: Xuerui Zhang, Lulu Song, Lin Li, Banghui Zhu, Lina Huo, Zhaoqing Hu, Xinran Wang, Jie Wang, Mengyue Gao, Jing Zhang and Zichun Hua

Journal: Signal transduction and targeted therapy

PubMed ID: 34131110

Doi: 10.1038/s41392-021-00626-z

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Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L - Acan mouse model

Authors: Schmidt S,Stapf C,Schmutzler S,Lachmann I,Arendt T,Holzer M,Sonntag M,Morawski M

Journal: The European journal of neuroscience

PubMed ID: 32737917

Doi: 10.1111/ejn.14923

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A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Authors: Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Takafumi Hiramoto, Hiroaki Mizukami, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34485602

Doi: 10.1016/j.omtm.2021.06.004

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Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis

Authors: Hai-Ping Xu, Xiao-Ying Ma, Chen Yang

Journal: Front Mol Biosci

PubMed ID: 34250012

Doi: 10.3389/fmolb.2021.660269

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High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP

Authors: Hyun Tae Lee, Ui Beom Park, Tae Jun Jeong, Nahyeon Gu, Sang Hyung Lee, Yujin Kim, Yong-Seok Heo

Journal: Biochem Biophys Res Commun

PubMed ID: 34144500

Doi: 10.1016/j.bbrc.2021.06.030

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Delayed KCNQ1/KCNE1 assembly on the cell surface helps I fulfil its function as a repolarization reserve in the heart

Authors: Zachary T Wilson, Min Jiang, Jing Geng, Sukhleen Kaur, Samuel W Workman, Jon Hao, Tytus Bernas, Gea-Ny Tseng

Journal: J Physiol

PubMed ID: 33963564

Doi: 10.1113/JP281773

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Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density

Authors: Brittany N Araj, Bruce Swihart, Robert Morrison, Patricia Gonzales Hurtado, Andrew Teo, Almahamoudou Mahamar, Oumar Attaher, Bacary S Diarra, Santara Gaoussou, Djibrilla Issiaka, Alassane Dicko, Patrick E Duffy, Michal Fried

Journal: mSystems

PubMed ID: 34128693

Doi: 10.1128/mSystems.00347-21

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Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries

Authors: Sakkarapalayam M Mahalingam, Karson S Putt, Madduri Srinivasarao, Philip S Low

Journal: Molecules

PubMed ID: 34205289

Doi: 10.3390/molecules26123739

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Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

Authors: Jiachen Huang, Pradeep Chopra, Lin Liu, Tamas Nagy, Jackelyn Murray, Ralph A Tripp, Geert-Jan Boons, Jarrod J Mousa

Journal: J Virol

PubMed ID: 34160259

Doi: 10.1128/JVI.00593-21

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SARS-CoV-2-specific CD8 T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Authors: Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi Ho Nguyen

Journal: Immunol Cell Biol

PubMed ID: 34086357

Doi: 10.1111/imcb.12482

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Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation

Authors: Naira Samarina, George Ssebyatika, Tanvi Tikla, Ja-Yun Waldmann, Bizunesh Abere, Vittoria Nanna, Michelangelo Marasco, Teresa Carlomagno, Thomas Krey, Thomas F Schulz

Journal: PLoS Pathog

PubMed ID: 34143834

Doi: 10.1371/journal.ppat.1009635

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Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaiti Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, Cameron Chow, Lauren Carter, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, David Baker

Journal: biorxiv

PubMed ID: 34189528

Doi: 10.1101/2021.06.22.449355

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Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

Authors: Hiroto Takeuchi, Satoru Konnai, Naoya Maekawa, Satoshi Takagi, Hiroshi Ohta, Noboru Sasaki, Sangho Kim, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Journal: Front Vet Sci

PubMed ID: 34195245

Doi: 10.3389/fvets.2021.656715

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The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Authors: Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin

Journal: Mol Cell Endocrinol

PubMed ID: 34126188

Doi: 10.1016/j.mce.2021.111366

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Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Authors: Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He

Journal: Mol Med Rep

PubMed ID: 34165172

Doi: 10.3892/mmr.2021.12231

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Serological survey of antibodies against SARS-CoV-2 in dogs and cats, Thailand

Authors: Kitikhun Udom, Waleemas Jairak, Ekkapat Chamsai, Kamonpan Charoenkul, Supanat Boonyapisitsopa, Napawan Bunpapong, Navapon Techakriengkrai, Alongkorn Amonsin

Journal: Transbound Emerg Dis

PubMed ID: 34180590

Doi: 10.1111/tbed.14208

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Design and in silico analysis of a whole-cell biosensor able to kill methicillin-resistant Staphylococcus aureus

Authors: Diego Francisco Benítez-Chao, Francisco de Jesús Balderas-Cisneros, Angel León-Buitimea, José Rubén Morones-Ramírez

Journal: Biotechnol Appl Biochem

PubMed ID: 34081352

Doi: 10.1002/bab.2210

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Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Authors: Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna

Journal: J Immunol

PubMed ID: 34162728

Doi: 10.4049/jimmunol.2001462

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients

Authors: Raquel Rubio-Acero, Noemi Castelletti, Volker Fingerle, Laura Olbrich, Abhishek Bakuli, Roman Wölfel, Philipp Girl, Katharina Müller, Simon Jochum, Matthias Strobl, Michael Hoelscher, Andreas Wieser

Journal: Infect Dis Ther

PubMed ID: 34155471

Doi: 10.1007/s40121-021-00475-x

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Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis

Authors: Jiajia Jiang, Rong Li, Junyi Wang, Jie Hou, Hui Qian, Wenrong Xu

Journal: Gastroenterol Res Pract

PubMed ID: 34221006

Doi: 10.1155/2021/5583029

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CRKL is a critical target of Hh-GLI2 pathway in lung adenocarcinoma

Authors: Xiaoming Liu, Yan Hu, Bentong Yu, Kai Peng, Xin Gan

Journal: J Cell Mol Med

PubMed ID: 34076957

Doi: 10.1111/jcmm.16592

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A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract

Authors: Qing Chen, Maaike de Vries, Kingsley Okechukwu Nwozor, Jacobien A Noordhoek, Corry-Anke Brandsma, H Marike Boezen, Irene H Heijink

Journal: Front Physiol

PubMed ID: 34163376

Doi: 10.3389/fphys.2021.690936

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A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis

Authors: Shiqiang Hou, Gengming Niu, Xin Liu, Pierre M Bourbon, Dongmei Zhang, Pengfei Cui, Kevin Zhao, Dezheng Zhao, Huiyan Zeng

Journal: Microvasc Res

PubMed ID: 34146582

Doi: 10.1016/j.mvr.2021.104209

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Secondary Structure of the Novel Myosin Binding Domain WYR and Implications within Myosin Structure

Authors: Lynda M Menard, Neil B Wood, Jim O Vigoreaux

Journal: Biology (Basel)

PubMed ID: 34209926

Doi: 10.3390/biology10070603

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Identification of ACE2 modifiers by CRISPR screening

Authors: Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer

Journal: biorxiv

PubMed ID: 34127970

Doi: 10.1101/2021.06.10.447768

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Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts

Authors: Yuanxin Li, Lixin Wang, Xueni Liu, Ying Huang, Xiaomei Li, Hong He, Xiaoyan Xu, Yujie Guo, Qi Li, Dan Zhu, Xingyu Wang, Haiyang Wang, Wenwen Li, Dan Li, Peng Xie

Journal: Neurochem Res

PubMed ID: 34165668

Doi: 10.1007/s11064-021-03385-z

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Large-Scale Oligonucleotide Synthesis for Whole-Genome Synthesis and Data Storage: Challenges and Opportunities

Authors: Li-Fu Song, Zheng-Hua Deng, Zi-Yi Gong, Lu-Lu Li, Bing-Zhi Li

Journal: Front Bioeng Biotechnol

PubMed ID: 34239862

Doi: 10.3389/fbioe.2021.689797

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Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases

Authors: Yiwen Zhang, Jiawei Yang, Siqi Yang, Jieze Zhang, Jun Chen, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang

Journal: CRISPR J

PubMed ID: 34152213

Doi: 10.1089/crispr.2021.0018

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Comparing Results of Five SARS-CoV-2 Antibody Assays Before and After the First Dose of ChAdOx1 nCoV-19 Vaccine among Health Care Workers

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34191577

Doi: 10.1128/JCM.01105-21

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Absence of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in stray cats

Authors: Angelica Stranieri, Stefania Lauzi, Alessia Giordano, Luigi Galimberti, Gabriele Ratti, Nicola Decaro, Federica Brioschi, Davide Lelli, Silvia Gabba, Ndiana Linda Amarachi, Eleonora Lorusso, Ana Moreno, Tiziana Trogu, Saverio Paltrinieri

Journal: Transbound Emerg Dis

PubMed ID: 34170624

Doi: 10.1111/tbed.14200

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Model infant biscuits release the opioid-acting peptides milk β-casomorphins and gluten exorphins after in vitro gastrointestinal digestion

Authors: Valentina Pica, Milda Stuknytė, Fabio Masotti, Ivano De Noni, Stefano Cattaneo

Journal: Food Chem

PubMed ID: 34118509

Doi: 10.1016/j.foodchem.2021.130262

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De novo biosynthesis of -arabinosylated flavones by utilization of rice -glycosyltransferases

Authors: Zhuo Chen, Yuwei Sun, Guangyi Wang, Ying Zhang, Qian Zhang, Yulian Zhang, Jianhua Li, Yong Wang

Journal: Bioresour Bioprocess

PubMed ID: 34150466

Doi: 10.1186/s40643-021-00404-3

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ptFVa ( Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C

Authors: Mark Schreuder, Xiaosong Liu, Ka Lei Cheung, Pieter H Reitsma, Gerry A F Nicolaes, Mettine H A Bos

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34162230

Doi: 10.1161/ATVBAHA.121.316038

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