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Tumor Microenvironment Responsive Pepper Mild Mottle Virus-Based Nanotubes for Targeted Delivery and Controlled Release of Paclitaxel

Authors: Jiejun Peng, Yueyan Yin, Hongze Liang, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Jianping Chen, Fei Yan, Jingbo Hu

Journal: Front Bioeng Biotechnol

PubMed ID: 34660562

Doi: 10.3389/fbioe.2021.763661

Products & Services: Protein and Antibody Isolation

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma

Authors: Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin, Angela L Meunier, Yifan Dang, Beth Ostaszewski, Alison C Pietras, Andrew M Stern, Dennis J Selkoe

Journal: Alzheimers Dement

PubMed ID: 34550630

Doi: 10.1002/alz.12457

Products & Services: Mutagenesis Services

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Authors: Lisa M Strong, Chunmei Chang, Julia F Riley, C Alexander Boecker, Thomas G Flower, Cosmo Z Buffalo, Xuefeng Ren, Andrea Kh Stavoe, Erika Lf Holzbaur, James H Hurley

Journal: Elife

PubMed ID: 34505572

Doi: 10.7554/eLife.70372

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Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

Authors: Naglaa Salem El-Sayed, Alexander S Jureka, Megan R Edwards, Sandeep Lohan, Caroline G Williams, Patrick T Keiser, Robert A Davey, Jennifer Totonchy, Rakesh K Tiwari, Christopher F Basler, Keykavous Parang

Journal: Eur J Med Chem

PubMed ID: 34583312

Doi: 10.1016/j.ejmech.2021.113862

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Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Authors: Hannah A D King, M Gordon Joyce, Ines Lakhal-Naouar, Aslaa Ahmed, Camila Macedo Cincotta, Caroline Subra, Kristina K Peachman, Holly R Hack, Rita E Chen, Paul V Thomas, Wei-Hung Chen, Rajeshwer S Sankhala, Agnes Hajduczki, Elizabeth J Martinez, Caroline E Peterson, William C Chang, Misook Choe, Clayton Smith, Jarrett A Headley, Hanne A Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James B Case, Jeffrey R Currier, Kerri G Lal, Mihret F Amare, Vincent Dussupt, Sebastian Molnar, Sharon P Daye, Xiankun Zeng, Erica K Barkei, Kendra Alfson, Hilary M Staples, Ricardo Carrion, Shelly J Krebs, Dominic Paquin-Proulx, Nicos Karasavvas, Victoria R Polonis, Linda L Jagodzinski, Sandhya Vasan, Paul T Scott, Yaoxing Huang, Manoj S Nair, David D Ho, Natalia de Val, Michael S Diamond, Mark G Lewis, Mangala Rao, Gary R Matyas, Gregory D Gromowski, Sheila A Peel, Nelson L Michael, Kayvon Modjarrad, Diane L Bolton

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34470866

Doi: 10.1073/pnas.2106433118

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Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B

Authors: Chan Yul Yoo, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G Chong, Joseph Hahm, Nicholas Morffy, Pei Zhou, Lucia C Strader, Akira Nagatani, Beixin Mo, Xuemei Chen, Meng Chen

Journal: Nat Commun

PubMed ID: 34556672

Doi: 10.1038/s41467-021-25909-5

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A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

Authors: Jessica P Kuppan, Margaret D Mitrovich, Michael D Vahey

Journal: Elife

PubMed ID: 34586067

Doi: 10.7554/eLife.70575

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Intracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum

Authors: Claudie Bian, Anna Marchetti, Philippe Hammel, Pierre Cosson

Journal: BMC Mol Cell Biol

PubMed ID: 34587896

Doi: 10.1186/s12860-021-00387-1

Products & Services: Protein Electrophoresis and Western

The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor

Authors: Rashad Haidar, Frank Henkler, Josephine Kugler, Aline Rosin, Doris Genkinger, Peter Laux, Andreas Luch

Journal: Sci Rep

PubMed ID: 34521881

Doi: 10.1038/s41598-021-97507-w

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Intradermal ChAdOx1 Vaccine Following Two CoronaVac Shots: A Case Report

Authors: Ekachai Singhatiraj, Krit Pongpirul, Anan Jongkaewwattana, Nattiya Hirankarn

Journal: Vaccines (Basel)

PubMed ID: 34579227

Doi: 10.3390/vaccines9090990

A combination of mRNA features influence the efficiency of leaderless mRNA translation initiation

Authors: Mohammed-Husain M Bharmal, Alisa Gega, Jared M Schrader

Journal: NAR Genom Bioinform

PubMed ID: 34568822

Doi: 10.1093/nargab/lqab081

Products & Services: Mutant Libraries

HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate

Authors: Wenguang He, Sarah Batty-Stuart, Jeffrey E Lee, Michael Ohh

Journal: J Mol Biol

PubMed ID: 34537235

Doi: 10.1016/j.jmb.2021.167244

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Brain adiponectin signaling controls peripheral insulin response in Drosophila

Authors: Nathalie Arquier, Marianne Bjordal, Philippe Hammann, Lauriane Kuhn, Pierre Léopold

Journal: Nat Commun

PubMed ID: 34561451

Doi: 10.1038/s41467-021-25940-6

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Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

Authors: Veronica Di Sarno, Gianluigi Lauro, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Marina Sala, Maria Carmina Scala, Gerardina Smaldone, Francesca Di Matteo, Sara Novi, Mario Felice Tecce, Ornella Moltedo, Giuseppe Bifulco, Pietro Campiglia, Isabel M Gomez-Monterrey, Robert Snoeck, Graciela Andrei, Carmine Ostacolo, Alessia Bertamino

Journal: Eur J Med Chem

PubMed ID: 34571172

Doi: 10.1016/j.ejmech.2021.113863

Products & Services: Protein and Antibody Isolation

Clean and folded: Production of active, high quality recombinant human interferon-λ1

Authors: Aram Shaldzhyan, Yana Zabrodskaya, Nikita Yolshin, Tatiana Kudling, Alexey Lozhkov, Marina Plotnikova, Edward Ramsay, Aleksandr Taraskin, Peter Nekrasov, Mikhail Grudinin, Andrey Vasin

Journal: Process Biochem

PubMed ID: 34493923

Doi: 10.1016/j.procbio.2021.08.029

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Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Authors: Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu, Qiang Liu

Journal: Mol Neurodegener

PubMed ID: 34551807

Doi: 10.1186/s13024-021-00485-w

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Evaluation of bacterial hosts for conversion of lignin-derived p-coumaric acid to 4-vinylphenol

Authors: Alberto Rodriguez, Jamie A Meadows, Ning Sun, Blake A Simmons, John M Gladden

Journal: Microb Cell Fact

PubMed ID: 34526022

Doi: 10.1186/s12934-021-01670-8

Products & Services: Bacterial Expression

Efficient acquisition of tens of thousands of short tandem repeats in single-cell whole-genome-amplified DNA

Authors: Liming Tao, Zipora Marx, Ofir Raz, Ehud Shapiro

Journal: STAR Protoc

PubMed ID: 34585162

Doi: 10.1016/j.xpro.2021.100828

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Poor Neutralizing Antibody Responses in 132 Patients with CLL, NHL and HL after Vaccination against SARS-CoV-2: A Prospective Study

Authors: Evangelos Terpos, Maria Gavriatopoulou, Despina Fotiou, Chara Giatra, Ioannis Asimakopoulos, Maria Dimou, Aimilia D Sklirou, Ioannis Ntanasis-Stathopoulos, Ismini Darmani, Alexandros Briasoulis, Efstathios Kastritis, Maria Angelopoulou, Ioannis Baltadakis, Panayiotis Panayiotidis, Ioannis P Trougakos, Theodoros P Vassilakopoulos, Maria Pagoni, Meletios A Dimopoulos

Journal: Cancers (Basel)

PubMed ID: 34503290

Doi: 10.3390/cancers13174480

l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters

Authors: Khuong T L Nguyen, Jhih-Yi Chiou, You-Chi Liu, Fang-Ju Cheng, Yi-Cheng Shen, Chao-Jung Chen, Chih-Hsin Tang, Wei-Chien Huang, Chia-Hung Chen, Chih-Yen Tu

Journal: J Cell Physiol

PubMed ID: 34472101

Doi: 10.1002/jcp.30570

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Intrauterine immunizations trigger antigen-specific mucosal and systemic immunity in pigs and passive protection in suckling piglets

Authors: P Choudhary, K R Fourie, S Ng, G Hamonic, N Bérubé, Y Popowych, H L Wilson

Journal: Vaccine

PubMed ID: 34535320

Doi: 10.1016/j.vaccine.2021.08.080

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Diversity and Evolution of and Transposons in the Apoidea Genomes

Authors: Yibing Liu, Wencheng Zong, Mohamed Diaby, Zheguang Lin, Saisai Wang, Bo Gao, Ting Ji, Chengyi Song

Journal: Biology (Basel)

PubMed ID: 34571816

Doi: 10.3390/biology10090940

Products & Services: Protein Tools

Development and Clinical Evaluation of a CRISPR-Based Diagnostic for Rapid Group B Streptococcus Screening

Authors: Lingxiao Jiang, Weiqi Zeng, Wanting Wu, Yingying Deng, Fusheng He, Wenli Liang, Mingyao Huang, Hong Huang, Yongjun Li, Xiaorui Wang, Hang Su, Shilei Pan, Teng Xu

Journal: Emerg Infect Dis

PubMed ID: 34424183

Doi: 10.3201/eid2709.200091

Products & Services: Codon Optimization

Wilson WRKY2 Regulates Chitinase Gene Expression During the Response to the Root Rot Pathogen

Authors: Shan Li, Jun Hai, Zie Wang, Jie Deng, Tingting Liang, Linlin Su, Diqiu Liu

Journal: Front Plant Sci

PubMed ID: 34646290

Doi: 10.3389/fpls.2021.741463

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LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis

Authors: Jingfeng Gu, Liang Dong, Yun Wang, Wenjia Nie, Wencong Liu, Ji-An Zhao

Journal: World J Surg Oncol

PubMed ID: 34535152

Doi: 10.1186/s12957-021-02389-x

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Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Authors: Maria Vono, Angela Huttner, Sylvain Lemeille, Paola Martinez-Murillo, Benjamin Meyer, Stephanie Baggio, Shilpee Sharma, Anais Thiriard, Arnaud Marchant, Gert-Jan Godeke, Chantal Reusken, Catia Alvarez, Francisco Perez-Rodriguez, Isabella Eckerle, Laurent Kaiser, Natasha Loevy, Christiane S Eberhardt, Geraldine Blanchard-Rohner, Claire-Anne Siegrist, Arnaud M Didierlaurent

Journal: Cell Rep

PubMed ID: 34587479

Doi: 10.1016/j.celrep.2021.109773

Influence of Switchgrass Genes on Vascular Development

Authors: Dongdong Tian, Jingwen Tang, Liwen Luo, Zhe Zhang, Kebing Du, Robert M Larkin, Xueping Shi, Bo Zheng

Journal: Front Plant Sci

PubMed ID: 34630487

Doi: 10.3389/fpls.2021.737219

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The Open Cell Form of 3D-Printed Titanium Improves Osteconductive Properties and Adhesion Behavior of Dental Pulp Stem Cells

Authors: Marialucia Gallorini, Susi Zara, Alessia Ricci, Francesco Guido Mangano, Amelia Cataldi, Carlo Mangano

Journal: Materials (Basel)

PubMed ID: 34576532

Doi: 10.3390/ma14185308

Products & Services: Protein and Antibody Isolation

The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation

Authors: Miriam Recalde, María Gárate-Rascón, María Elizalde, María Azkona, M Ujue Latasa, Marina Bárcena-Varela, Bruno Sangro, Maite G Fernández-Barrena, Matías A Ávila, María Arechederra, Carmen Berasain

Journal: Nucleic Acids Res

PubMed ID: 34331453

Doi: 10.1093/nar/gkab649

Products & Services: Plasmid DNA Preparation

Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase

Authors: Natalya Pashkova, Liping Yu, Nicholas J Schnicker, Chun-Che Tseng, Lokesh Gakhar, David J Katzmann, Robert C Piper

Journal: Mol Biol Cell

PubMed ID: 34586919

Doi: 10.1091/mbc.E21-04-0219

Products & Services: Gene Synthesis

Seroprevalence and detection of Trypanosoma cruzi in dogs living in a non-endemic area for Chagas disease in the legal Amazon region, Brazil

Authors: Thaliane França Costa, Ana Vitória Verde Oliveira Rocha, Leandro Macedo Miranda, Larissa Fernanda Soares Lima, Fred Luciano Neves Santos, Ângelo Antônio Oliveira Silva, Fernando Almeida-Souza, Anaiá da Paixão Sevá, Aline Diniz Cabral, Márcia Aparecida Sperança, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Andréa Pereira da Costa

Journal: Vet Parasitol Reg Stud Reports

PubMed ID: 34879958

Doi: 10.1016/j.vprsr.2021.100648

Products & Services: Protein and Antibody Isolation

Knockdown of lncRNA TUG1 protects lens epithelial cells from oxidative stress-induced injury by regulating miR-196a-5p expression in age-related cataracts

Authors: Qimin Shen, Tian Zhou

Journal: Exp Ther Med

PubMed ID: 34630641

Doi: 10.3892/etm.2021.10721

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Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E coli

Authors: Gloria Narayan, Akriti Agrawal, Neha Joshi, Ranadeep Gogoi, Shirisha Nagotu, Rajkumar P Thummer

Journal: Protein J

PubMed ID: 34550497

Doi: 10.1007/s10930-021-10020-x

Products & Services: Mammalian Expression

Function Is More Reliable than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination

Authors: Carlos A A Sariol, Petraleigh Pantoja, Crisanta Serrano-Collazo, Tiffany Rosa-Arocho, Albersy Armina-Rodríguez, Lorna Cruz, E Taylor Taylor Stone, Teresa Arana, Consuelo Climent, Gerardo Latoni, Dianne Atehortua, Christina Pabon-Carrero, Amelia K K Pinto, James D D Brien, Ana M M Espino

Journal: Viruses

PubMed ID: 34696403

Doi: 10.3390/v13101972

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Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion

Authors: Tianhui Sun, Yuzhao Song, Dequn Teng, Yanan Chen, Jianli Dai, Mengqi Ma, Wei Zhang, José C Pastor-Pareja

Journal: Cell Rep

PubMed ID: 34496252

Doi: 10.1016/j.celrep.2021.109667

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in Swiss and Dutch Guinea Pigs-Occurrence and Genetic Diversity

Authors: Silvia Ciuria, Michael S M Brouwer, Marende M de Gier, Yvonne van Zeeland, Alex Bossers, Barbara Prähauser, Julia Schädler, Jean-Michel Hatt, Marloes Heijne, Nicole Borel

Journal: Pathogens

PubMed ID: 34684177

Doi: 10.3390/pathogens10101230

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Understanding the Adsorption of Peptides and Proteins onto PEGylated Gold Nanoparticles

Authors: Yasiru Randika Perera, Joanna Xiuzhu Xu, Dhanush L Amarasekara, Alex C Hughes, Ibraheem Abbood, Nicholas C Fitzkee

Journal: Molecules

PubMed ID: 34641335

Doi: 10.3390/molecules26195788

Products & Services: Recombinant Proteins

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Authors: Apurva T Prabhakar, Claire D James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T Fontan, Xu Wang, Sarah H Glass, Andreas Wieland, Mary M Donaldson, Molly L Bristol, Renfeng Li, Anthony W Oliver, Laurence H Pearl, Brian O Smith, Iain M Morgan

Journal: MBio

PubMed ID: 34544280

Doi: 10.1128/mBio.01163-21

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A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress

Authors: Verena Hurst, Kiran Challa, Felix Jonas, Romain Forey, Ragna Sack, Jan Seebacher, Christoph D Schmid, Naama Barkai, Kenji Shimada, Susan M Gasser, Jérôme Poli

Journal: EMBO J

PubMed ID: 34569643

Doi: 10.15252/embj.2021108439

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Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses

Authors: Florian Geiger, Julia Acker, Guido Papa, Xinyu Wang, William E Arter, Kadi L Saar, Nadia A Erkamp, Runzhang Qi, Jack Pk Bravo, Sebastian Strauss, Georg Krainer, Oscar R Burrone, Ralf Jungmann, Tuomas Pj Knowles, Hanna Engelke, Alexander Borodavka

Journal: EMBO J

PubMed ID: 34524703

Doi: 10.15252/embj.2021107711

Products & Services: Gene Fragments

Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis

Authors: Marketa Koberska, Ludmila Vesela, Vladimir Vimberg, Jakub Lenart, Jana Vesela, Zdenek Kamenik, Jiri Janata, Gabriela Balikova Novotna

Journal: MBio

PubMed ID: 34488446

Doi: 10.1128/mBio.01731-21

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Control of Gene Expression With Quercetin-Responsive Modular Circuits

Authors: Fernanda Miyuki Kashiwagi, Brenno Wendler Miranda, Fabio de Oliveira Pedrosa, Emanuel Maltempi de Souza, Marcelo Müller-Santos

Journal: Front Bioeng Biotechnol

PubMed ID: 34604189

Doi: 10.3389/fbioe.2021.730967

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A Neuroprotective Bovine Colostrum Attenuates Apoptosis in Dexamethasone-Treated MC3T3-E1 Osteoblastic Cells

Authors: Sagrario Martin-Aragon, Paloma Bermejo-Bescós, Juana Benedí, Carlos Raposo, Franklim Marques, Eirini K Kydonaki, Paraskevi Gkiata, Yiannis Koutedakis, Georgia Ntina, Andres E Carrillo, Tânia Amorim

Journal: Int J Mol Sci

PubMed ID: 34638536

Doi: 10.3390/ijms221910195

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Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Authors: Qibin Geng, Wanbo Tai, Victoria K Baxter, Juan Shi, Yushun Wan, Xiujuan Zhang, Stephanie A Montgomery, Sharon A Taft-Benz, Elizabeth J Anderson, Audrey C Knight, Kenneth H Dinnon, Sarah R Leist, Ralph S Baric, Jian Shang, Sung-Wook Hong, Aleksandra Drelich, Chien-Te K Tseng, Marc Jenkins, Mark Heise, Lanying Du, Fang Li

Journal: PLoS Pathog

PubMed ID: 34492082

Doi: 10.1371/journal.ppat.1009897

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Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

Authors: Shanshan Li, Kan-Yen Hsieh, Shih-Chieh Su, Grigore D Pintilie, Kaiming Zhang, Chung-I Chang

Journal: J Biol Chem

PubMed ID: 34563541

Doi: 10.1016/j.jbc.2021.101239

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Structural insights into the activation of human calcium-sensing receptor

Authors: Xiaochen Chen, Lu Wang, Qianqian Cui, Zhanyu Ding, Li Han, Yongjun Kou, Wenqing Zhang, Haonan Wang, Xiaomin Jia, Mei Dai, Zhenzhong Shi, Yuying Li, Xiyang Li, Yong Geng

Journal: Elife

PubMed ID: 34467854

Doi: 10.7554/eLife.68578

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Neuromedin B receptor stimulation of Cav32 T-type Ca channels in primary sensory neurons mediates peripheral pain hypersensitivity

Authors: Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao

Journal: Theranostics

PubMed ID: 34646374

Doi: 10.7150/thno.62255

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Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Authors: Fredarla S Miller, Kathryn K Crone, Matthew R Jensen, Sudipta Shaw, William R Harcombe, Mikael H Elias, Michael F Freeman

Journal: Nat Commun

PubMed ID: 34504067

Doi: 10.1038/s41467-021-25575-7

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Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation

Authors: Sarah M Glass, F Peter Guengerich

Journal: J Biol Chem

PubMed ID: 34480899

Doi: 10.1016/j.jbc.2021.101142

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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Authors: Kevin J Roberts, Marion F Cubitt, Timothy M Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T MacDonald, Keith P Ray, Anna Vossenkämper, Michael R West, J Scott Crowe

Journal: Sci Rep

PubMed ID: 34593832

Doi: 10.1038/s41598-021-97236-0

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Newt regeneration genes regulate Wingless signaling to restore patterning in eye

Authors: Abijeet Singh Mehta, Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Panagiotis A Tsonis, Amit Singh

Journal: iScience

PubMed ID: 34746690

Doi: 10.1016/j.isci.2021.103166

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Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Authors: Brandi T Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A Granek, Cliburn Chan, Soman N Abraham, Herman F Staats

Journal: Front Immunol

PubMed ID: 34566991

Doi: 10.3389/fimmu.2021.730346

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Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Salinthip Jarusintanakorn, Chutima Phechkrajang, Putthiporn Khongkaew, Enrico Mastrobattista, Montarop Yamabhai

Journal: Anal Bioanal Chem

PubMed ID: 34476523

Doi: 10.1007/s00216-021-03549-4

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Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells

Authors: Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana

Journal: Nutrients

PubMed ID: 34579029

Doi: 10.3390/nu13093152

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Manipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria

Authors: Nhan D T Tram, Vanitha Selvarajan, Alister Boags, Devika Mukherjee, Jan K Marzinek, Bernadette Cheng, Zi-Chen Jiang, Pascal Goh, Jun-Jie Koh, Jeanette W P Teo, Peter J Bond, Pui Lai Rachel Ee

Journal: Acta Biomater

PubMed ID: 34506975

Doi: 10.1016/j.actbio.2021.09.004

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A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

Authors: Houyu Ju, Zhenrong Hu, Dongliang Wei, Jinyun Huang, Xinyi Zhang, Mengyu Rui, Zhi Li, Xiaomeng Zhang, Jingzhou Hu, Wei Guo, Guoxin Ren

Journal: Cancer Commun (Lond)

PubMed ID: 34498800

Doi: 10.1002/cac2.12213

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Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE

Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda

Journal: Immun Inflamm Dis

PubMed ID: 34533288

Doi: 10.1002/iid3.531

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Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Kozeta Libohova, Jessica R Blount, Alyson L Sujkowski, Matthew V Prifti, Wei-Ling Tsou, Sokol V Todi

Journal: Neurobiol Dis

PubMed ID: 34563642

Doi: 10.1016/j.nbd.2021.105516

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Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Authors: Jaya Joshi, Qiang Li, Jorge D García-García, Bryan J Leong, You Hu, Steven D Bruner, Andrew D Hanson

Journal: Biochem J

PubMed ID: 34409984

Doi: 10.1042/BCJ20210565

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Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Authors: Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan

Journal: Mol Med Rep

PubMed ID: 34558634

Doi: 10.3892/mmr.2021.12458

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Transcriptome Reprogramming of Tomato Orchestrate the Hormone Signaling Network of Systemic Resistance Induced by

Authors: Jagmohan Singh, Rashmi Aggarwal, Bishnu Maya Bashyal, K Darshan, Pooja Parmar, M S Saharan, Zakir Hussain, Amolkumar U Solanke

Journal: Front Plant Sci

PubMed ID: 34630468

Doi: 10.3389/fpls.2021.721193

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Precise Characterization of Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies

Authors: Wei Lu, Xinhui Lan, Tong Zhang, Hao Sun, Sanyuan Ma, Qingyou Xia

Journal: Insects

PubMed ID: 34564273

Doi: 10.3390/insects12090832

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A Plant-Produced Virus-Like Particle Displaying Envelope Protein Domain III Elicits an Immune Response Against West Nile Virus in Mice

Authors: Jennifer Stander, Aleyo Chabeda, Edward P Rybicki, Ann E Meyers

Journal: Front Plant Sci

PubMed ID: 34589108

Doi: 10.3389/fpls.2021.738619

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Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Authors: Moisés Martínez Velázquez, Carla Patricia Barragán Álvarez, José Miguel Flores Fernández, Rodolfo Esteban Lagunes Quintanilla, Edgar Castro Saines, Patricia Berenice Ramírez Rodríguez, Sara Elisa Herrera Rodríguez, Rodolfo Hernández Gutiérrez, Abel Gutiérrez Ortega, Ángel H Álvarez

Journal: Parasite

PubMed ID: 34533454

Doi: 10.1051/parasite/2021064

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Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers

Authors: Theodore W Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger

Journal: Int J Infect Dis

PubMed ID: 34601142

Doi: 10.1016/j.ijid.2021.09.065

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Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8 T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma

Authors: Hailin Zhang, Yonghui Zhang, Jie Dong, Shuguang Zuo, Gang Meng, Junhua Wu, Jiwu Wei

Journal: Cell Oncol (Dordr)

PubMed ID: 34491549

Doi: 10.1007/s13402-021-00633-w

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Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)

Authors: Nazli Sotoudeh, Zahra Noormohammadi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht, Mahdi Behdani

Journal: Iran J Basic Med Sci

PubMed ID: 35083014

Doi: 10.22038/IJBMS.2021.57774.12851

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Novel Homologs of Isopentenyl Phosphate Kinase Reveal Class-Wide Substrate Flexibility

Authors: Vikas Kumar , Bryce P Johnson , Dustin A Dimas , Shanteri Singh

Journal: ChemCatChem

PubMed ID: 34630731

Doi: 10.1002/cctc.202100595

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Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to confer full host defense against tospovirus infection

Authors: Hongyu Chen , Xin Qian , Xiaojiao Chen , Tongqing Yang , Mingfeng Feng , Jing Chen , Ruixiang Cheng , Hao Hong , Ying Zheng , Yuzhen Mei , Danyu Shen , Yi Xu , Min Zhu , Xin Shun Ding , Xiaorong Tao

Journal: New Phytol

PubMed ID: 34096619

Doi: 10.1111/nph.17535

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Assessment of IsPETase-Assisted Depolymerization of Terephthalate Aromatic Polyesters and the Effect of the Thioredoxin Fusion Domain

Authors: Paula Wagner-Egea ,Virginia Tosi ,Ping Wang ,Carl Grey,Baozhong Zhang and Javier A. Linares-Pastén

Journal: applied sciences

Doi: 10.3390/app11188315

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Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv

Authors: Gino L Turra, Linda Liedgens, Frederik Sommer, Luzia Schneider, David Zimmer, Jordi Vilurbina Perez, Sasa Koncarevic, Michael Schroda, Timo Mühlhaus, Marcel Deponte

Journal: Microbiol Spectr

PubMed ID: 34585988

Doi: 10.1128/Spectrum.00809-21

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One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases-Utah and Wisconsin, 2020

Authors: Grace W Goryoka, Caitlin M Cossaboom, Radhika Gharpure, Patrick Dawson, Cassandra Tansey, John Rossow, Victoria Mrotz, Jane Rooney, Mia Torchetti, Christina M Loiacono, Mary L Killian, Melinda Jenkins-Moore, Ailam Lim, Keith Poulsen, Dan Christensen, Emma Sweet, Dallin Peterson, Anna L Sangster, Erin L Young, Kelly F Oakeson, Dean Taylor, Amanda Price, Tair Kiphibane, Rachel Klos, Darlene Konkle, Sanjib Bhattacharyya, Trivikram Dasu, Victoria T Chu, Nathaniel M Lewis, Krista Queen, Jing Zhang, Anna Uehara, Elizabeth A Dietrich, Suxiang Tong, Hannah L Kirking, Jeffrey B Doty, Laura S Murrell, Jessica R Spengler, Anne Straily, Ryan Wallace, Casey Barton Behravesh

Journal: Viruses

PubMed ID: 34578394

Doi: 10.3390/v13091813

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Profiles of spp Isolated from the Rhizosphere of Suaeda glauca and Their Potential to Promote Plant Growth and Suppress Fungal Phytopathogens

Authors: Ping Lu, Ke Jiang, Ya-Qiao Hao, Wan-Ying Chu, Yu-Dong Xu, Jia-Yao Yang, Jia-Le Chen, Guo-Hong Zeng, Zhou-Hang Gu, Hong-Xin Zhao

Journal: J Microbiol Biotechnol

PubMed ID: 34261851

Doi: 10.4014/jmb.2105.05010

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Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA

Authors: Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgio, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina, Rita Carsetti

Journal: Cells

PubMed ID: 34685521

Doi: 10.3390/cells10102541

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Structures of foot-and-mouth disease virus with bovine neutralizing antibodies reveal the determinant of intra-serotype cross-neutralization

Authors: Yong He, Kun Li, Li Wang, Zixian Sun, Yimei Cao, Pinghua Li, Pu Sun, Huifang Bao, Shasha Zhou, Sheng Wang, Xingwen Bai, Xuerong Liu, Lixia Zhao, Xiuli Fan, Zaixin Liu, Zengjun Lu, Cheng Yang, Zhiyong Lou

Journal: J Virol

PubMed ID: 34586859

Doi: 10.1128/JVI.01308-21

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Biocatalytic synthesis of 2-O-α-D-glucopyranosyl-L-ascorbic acid using an extracellular expressed α-glucosidase from Oryza sativa

Authors: Xuelian Qi, Junlan Shao, Yinchu Cheng, Xiaoying He, Yan Li, Honghua Jia, Ming Yan

Journal: Biotechnol J

PubMed ID: 34392609

Doi: 10.1002/biot.202100199

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Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module

Authors: Kayleigh M Voos, Wenpeng Cao, Nicholas A Arce, Emily R Legan, Yingchun Wang, Asif Shajahan, Parastoo Azadi, Pete Lollar, Xiaohui Frank Zhang, Renhao Li

Journal: J Thromb Haemost

PubMed ID: 34529349

Doi: 10.1111/jth.15528

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Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells

Authors: Hongzhi Sun, Hongmei Ma, Hao Zhang, Minjun Ji

Journal: Int J Biol Sci

PubMed ID: 34671205

Doi: 10.7150/ijbs.62517

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Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II

Authors: Madison M Smith, Brett A Beaupre, Dariush C Fourozesh, Kathleen M Meneely, Audrey L Lamb, Graham R Moran

Journal: Biochemistry

PubMed ID: 34569786

Doi: 10.1021/acs.biochem.1c00511

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Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction

Authors: Daniel Birtles, Jinwoo Lee

Journal: Biochemistry

PubMed ID: 34570469

Doi: 10.1021/acs.biochem.1c00543

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LvCPG2 facilitated WSSV infection by interaction with VP26 and VP28

Authors: Xing-Chao Ren, Qing-Hui Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34562580

Doi: 10.1016/j.fsi.2021.09.019

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Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in

Authors: Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M Blom

Journal: Front Immunol

PubMed ID: 34539665

Doi: 10.3389/fimmu.2021.726801

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Evolutionary study of maize dwarf mosaic virus using nearly complete genome sequences acquired by next-generation sequencing

Authors: Dulanjani Wijayasekara, Akhtar Ali

Journal: Sci Rep

PubMed ID: 34552152

Doi: 10.1038/s41598-021-98299-9

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Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees

Authors: Gabriela de Brito Sanchez, Anna Expósito Muñoz, Li Chen, Weifone Huang, Songkun Su, Martin Giurfa

Journal: Sci Rep

PubMed ID: 34526585

Doi: 10.1038/s41598-021-97851-x

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Effect of γ-aminobutyric Acid on Phenolics Metabolism in Barley Seedlings under Low NaCl Treatment

Authors: Mian Wang, Yahui Zhu, Pei Wang, Zhenxin Gu, Runqiang Yang

Journal: Antioxidants (Basel)

PubMed ID: 34573053

Doi: 10.3390/antiox10091421

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Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Authors: Emery T Usher, Kevin E W Namitz, Michael S Cosgrove, Scott A Showalter

Journal: Biophys J

PubMed ID: 34592262

Doi: 10.1016/j.bpj.2021.09.034

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Single-molecule optical tweezers reveals folding steps of the domain swapping mechanism of a protein

Authors: Andres Bustamante, Rodrigo Rivera, Martin Floor, Jorge Babul, Mauricio Baez

Journal: Biophys J

PubMed ID: 34555362

Doi: 10.1016/j.bpj.2021.09.026

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Authors: Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L Pennington, Tsz-Ming Tsang, Madison Frey, Erik J Soderblom, Huimin Geng, Markus Müschen, Tetyana V Forostyan, Savannah Free, Gaelle Mercenne, Courtney J Banks, Jonard Valdoz, Clifford J Whatcott, Jason M Foulks, David J Bearss, Thomas O'Hare, David C S Huang, Kenneth A Christensen, James Moody, Steven L Warner, Jeffrey W Tyner, Joshua L Andersen

Journal: Nat Commun

PubMed ID: 34504101

Doi: 10.1038/s41467-021-25622-3

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Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Authors: Reina Bassil, Kenneth Shields, Kevin Granger, Ivan Zein, Shirley Ng, Ben Chih

Journal: Nat Commun

PubMed ID: 34471104

Doi: 10.1038/s41467-021-25344-6

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Generation of stable cell lines using readthrough expression from lentiviral integration

Authors: Anish Jadav, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 34533680

Doi: 10.1007/s10529-021-03186-y

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Expression of the ISPpu9 transposase of Pseudomonas putida KT2440 is regulated by two small RNAs and the secondary structure of the mRNA 5'-untranslated region

Authors: Guillermo Gómez-García, Angel Ruiz-Enamorado, Luis Yuste, Fernando Rojo, Renata Moreno

Journal: Nucleic Acids Res

PubMed ID: 34379788

Doi: 10.1093/nar/gkab672

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Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis

Authors: Bin Wei, Ya-Kun Wang, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu, Hong Wang

Journal: J Microbiol

PubMed ID: 34554454

Doi: 10.1007/s12275-021-1292-4

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Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens

Authors: Eeva M Marttinen, Mikko T Lehtonen, Nico van Gessel, Ralf Reski, Jari P T Valkonen

Journal: Plant Cell Environ

PubMed ID: 34564869

Doi: 10.1111/pce.14194

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DcCCD4 catalyzes the degradation of α-carotene and β-carotene to affect carotenoid accumulation and taproot color in carrot

Authors: Tong Li, Yuan-Jie Deng, Jie-Xia Liu, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: Plant J

PubMed ID: 34547154

Doi: 10.1111/tpj.15498

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Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

Authors: Sawsan S Alamri, Khalid A Alluhaybi, Rowa Y Alhabbab, Mohammad Basabrain, Abdullah Algaissi, Sarah Almahboub, Mohamed A Alfaleh, Turki S Abujamel, Wesam H Abdulaal, M-Zaki ElAssouli, Rahaf H Alharbi, Mazen Hassanain, Anwar M Hashem

Journal: Front Microbiol

PubMed ID: 34557174

Doi: 10.3389/fmicb.2021.727455

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Molecular mechanism of interactions between ACAD9 and binding partners in mitochondrial respiratory complex I assembly

Authors: Chuanwu Xia, Baoying Lou, Zhuji Fu, Al-Walid Mohsen, Anna L Shen, Jerry Vockley, Jung-Ja P Kim

Journal: iScience

PubMed ID: 34646991

Doi: 10.1016/j.isci.2021.103153

Products & Services: DNA Sequencing

Infection Kinetics and Transmissibility of a Reanimated Dengue Virus Serotype 4 Identified Originally in Wild From Florida

Authors: Jasmine B Ayers, Xuping Xie, Heather Coatsworth, Caroline J Stephenson, Christy M Waits, Pei-Yong Shi, Rhoel R Dinglasan

Journal: Front Microbiol

PubMed ID: 34630357

Doi: 10.3389/fmicb.2021.734903

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A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Authors: Maria Dalgaard Mikkelsen, Hang Thi Thuy Cao, Thomas Roret, Nanna Rhein-Knudsen, Jesper Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Mateusz Jakub Lezyk, Jan Muschiol, Thinh Duc Pham, Mirjam Czjzek, Anne S Meyer

Journal: Sci Rep

PubMed ID: 34593864

Doi: 10.1038/s41598-021-98588-3

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Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties

Authors: Guoqiang Lin, Yingying Fei, Yanming Zhang

Journal: Immunopharmacol Immunotoxicol

PubMed ID: 34477035

Doi: 10.1080/08923973.2021.1963272

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Propofol induces the ferroptosis of colorectal cancer cells by downregulating STAT3 expression

Authors: Xining Zhao, Fei Chen

Journal: Oncol Lett

PubMed ID: 34589146

Doi: 10.3892/ol.2021.13028

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