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Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Authors: Qian-Qian Zhu, Xi-Bin Pu, Tian-Chi Chen, Chen-Yang Qiu, Zi-Heng Wu, Lu Tian, Yang-Yan He, Xiao-Hui Wang, Tao Shang, Xun Wang, Yi-Lang Xiang, Dong-Lin Li, Hong-Kun Zhang

Journal: Cell Cycle

PubMed ID: 34223793

Doi: 10.1080/15384101.2021.1918877

Products & Services: Custom DNA/RNA Oligos

The reductive carboxylation activity of heterotetrameric pyruvate synthases from hyperthermophilic archaea

Authors: Lu Xiao, Guoxia Liu, Fuyu Gong, Zhen Cai, Yin Li

Journal: Biochem Biophys Res Commun

PubMed ID: 34364295

Doi: 10.1016/j.bbrc.2021.07.091

Products & Services: Codon Optimization

Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated

Authors: Esther Broset, Juan Calvet Seral, Carmen Arnal, Santiago Uranga, Alex I Kanno, Luciana C C Leite, Carlos Martín, Jesús Gonzalo-Asensio

Journal: Comput Struct Biotechnol J

PubMed ID: 34429847

Doi: 10.1016/j.csbj.2021.07.035

Products & Services: Codon Optimization

Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution

Authors: Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K-S Wong, John L Spudich

Journal: MBio

PubMed ID: 34281394

Doi: 10.1128/mBio.01656-21

Products & Services: Codon Optimization

CD8 T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

Authors: Vamsee Mallajosyula, Conner Ganjavi, Saborni Chakraborty, Alana M McSween, Ana Jimena Pavlovitch-Bedzyk, Julie Wilhelmy, Allison Nau, Monali Manohar, Kari C Nadeau, Mark M Davis

Journal: Sci Immunol

PubMed ID: 34210785

Doi: 10.1126/sciimmunol.abg5669

Products & Services: Peptide Synthesis

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Authors: Tyler N Starr, Nadine Czudnochowski, Zhuoming Liu, Fabrizia Zatta, Young-Jun Park, Amin Addetia, Dora Pinto, Martina Beltramello, Patrick Hernandez, Allison J Greaney, Roberta Marzi, William G Glass, Ivy Zhang, Adam S Dingens, John E Bowen, M Alejandra Tortorici, Alexandra C Walls, Jason A Wojcechowskyj, Anna De Marco, Laura E Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, Josh R Dillen, Heather Tucker, Jessica Bassi, Chiara Silacci-Fregni, Michael P Housley, Julia di Iulio, Gloria Lombardo, Maria Agostini, Nicole Sprugasci, Katja Culap, Stefano Jaconi, Marcel Meury, Exequiel Dellota, Rana Abdelnabi, Shi-Yan Caroline Foo, Elisabetta Cameroni, Spencer Stumpf, Tristan I Croll, Jay C Nix, Colin Havenar-Daughton, Luca Piccoli, Fabio Benigni, Johan Neyts, Amalio Telenti, Florian A Lempp, Matteo S Pizzuto, John D Chodera, Christy M Hebner, Herbert W Virgin, Sean P J Whelan, David Veesler, Davide Corti, Jesse D Bloom, Gyorgy Snell

Journal: Nature

PubMed ID: 34261126

Doi: 10.1038/s41586-021-03807-6

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Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application

Authors: Filip Koper, Tomasz Swiergosz, Anna Żaba, Agata Flis, Martina Trávníčková, Lucie Bačáková, Elżbieta Pamuła, Dariusz Bogdał, Wiktor P Kasprzyk

Journal: J Mater Chem B

PubMed ID: 34323912

Doi: 10.1039/d1tb01078f

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Quantitative probing of glycosylated queuosine modifications in tRNA

Authors: Wen Zhang, Tao Pan

Journal: Methods Enzymol

PubMed ID: 34517960

Doi: 10.1016/bs.mie.2021.06.003

Products & Services: Recombinant Proteins

Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1

Authors: Nikole L Warner, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 34358143

Doi: 10.3390/vaccines9070726

Products & Services: Peptide Synthesis

CEACAM1 Activation by CbpF-Expressing

Authors: Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J Slade, Ofer Mandelboim, Gilad Bachrach

Journal: Front Cell Infect Microbiol

PubMed ID: 34395310

Doi: 10.3389/fcimb.2021.699015

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Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types

Authors: Jamil N Kanji, Ashley Bailey, Jayne Fenton, L Robbin Lindsay, Antonia Dibernardo, Nikki Pl Toledo, Brooks Waitt, Nadine Lecocq, Carla Osiowy, Elizabeth Giles, Jacqueline Day, William Stokes, Clayton MacDonald, LeeAnn Turnbull, Carmen Charlton

Journal: J Clin Virol

PubMed ID: 34364133

Doi: 10.1016/j.jcv.2021.104933

Products & Services: Proteins, Expression, Isolation and Analysis

Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species

Authors: Anberitha T Matthews, Hitesh Soni, Katherine E Robinson-Freeman, Theresa A John, Randal K Buddington, Adebowale Adebiyi

Journal: Int J Mol Sci

PubMed ID: 34299212

Doi: 10.3390/ijms22147589

Products & Services: Proteins, Expression, Isolation and Analysis

Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus

Authors: Yong Feng, Ping Wu, Chao Liu, Liwei Peng, Tao Wang, Chao Wang, Qian Tan, Bixuan Li, Yajuan Ou, Hui Zhu, Songli Yuan, Renliang Huang, Gary Stacey, Zhongming Zhang, Yangrong Cao

Journal: Mol Plant

PubMed ID: 34314895

Doi: 10.1016/j.molp.2021.07.016

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

Authors: Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 34266885

Doi: 10.1136/jitc-2021-002882

Products & Services: Proteins, Expression, Isolation and Analysis

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

Authors: Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V Catapano, Giuseppina M Carbone

Journal: Nat Commun

PubMed ID: 34230470

Doi: 10.1038/s41467-021-24380-6

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Authors: Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia

Journal: Sci Transl Med

PubMed ID: 34285130

Doi: 10.1126/scitranslmed.abg1143

Products & Services: Proteins, Expression, Isolation and Analysis

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

Authors: Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang

Journal: J Immunother Cancer

PubMed ID: 34230110

Doi: 10.1136/jitc-2021-002454

Products & Services: Proteins, Expression, Isolation and Analysis

Alfalfa (Medicago sativa L) MsCML46 gene encoding calmodulin-like protein confers tolerance to abiotic stress in tobacco

Authors: Binghao Du, Naiyu Chen, Lili Song, Dan Wang, Hongsheng Cai, Lin Yao, Xiuting Li, Changhong Guo

Journal: Plant Cell Rep

PubMed ID: 34322731

Doi: 10.1007/s00299-021-02757-7

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A Titratable Cell Lysis-on-Demand System for Droplet-Compartmentalized Ultrahigh-Throughput Screening in Functional Metagenomics and Directed Evolution

Authors: Che Fai Alex Wong, Liisa van Vliet, Swapnil Vilas Bhujbal, Chengzhi Guo, Marit Sletmoen, Bjørn Torger Stokke, Florian Hollfelder, Rahmi Lale

Journal: ACS Synth Biol

PubMed ID: 34260196

Doi: 10.1021/acssynbio.1c00084

Products & Services: Plasmid DNA Preparation

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Authors: Robert L Summers, Charisse Flerida A Pasaje, Joao P Pisco, Josefine Striepen, Madeline R Luth, Krittikorn Kumpornsin, Emma F Carpenter, Justin T Munro, De Lin, Andrew Plater, Avinash S Punekar, Andrew M Shepherd, Sharon M Shepherd, Manu Vanaerschot, James M Murithi, Kelly Rubiano, Aslı Akidil, Sabine Ottilie, Nimisha Mittal, A Hazel Dilmore, Madalyn Won, Rebecca E K Mandt, Kerry McGowen, Edward Owen, Chris Walpole, Manuel Llinás, Marcus C S Lee, Elizabeth A Winzeler, David A Fidock, Ian H Gilbert, Dyann F Wirth, Jacquin C Niles, Beatriz Baragaña, Amanda K Lukens

Journal: Cell Chem Biol

PubMed ID: 34348113

Doi: 10.1016/j.chembiol.2021.07.010

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Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism

Authors: Karen V Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 34354688

Doi: 10.3389/fmicb.2021.691731

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Mitofusion is required for MOTS-c induced GLUT4 translocation

Authors: Khushwant S Bhullar, Nan Shang, Evan Kerek, Kaiyu Wu, Jianping Wu

Journal: Sci Rep

PubMed ID: 34253808

Doi: 10.1038/s41598-021-93735-2

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Overexpression of the Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4 T Cell Activation

Authors: Daniel J Perry, Leeana D Peters, Priya Saikumar Lakshmi, Lin Zhang, Zhao Han, Clive H Wasserfall, Clayton E Mathews, Mark A Atkinson, Todd M Brusko

Journal: J Immunol

PubMed ID: 34301848

Doi: 10.4049/jimmunol.2000708

Products & Services: PCR Cloning and Subcloning

Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

Authors: Jannick Prentoe, Christoph M Janitzek, Rodrigo Velázquez-Moctezuma, Louise Goksøyr, Rebecca W Olsen, Margherita Fanalista, Elias H Augestad, Susan Thrane, Anne F Pihl, Judith M Gottwein, Adam F Sander, Jens Bukh

Journal: PLoS ONE

PubMed ID: 34329365

Doi: 10.1371/journal.pone.0255336

Products & Services: PCR Cloning and Subcloning

Recapture Lysosomal Enzyme Deficiency via Targeted Gene Disruption in the Human Near-Haploid Cell Line HAP1

Authors: Annie Brown, Jiayi Zhang, Brendan Lawler, Biao Lu

Journal: Genes (Basel)

PubMed ID: 34356092

Doi: 10.3390/genes12071076

Products & Services: PCR and Cloning

Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

Authors: Jing Cao, Lingjie Yang, Le Wang, Qian Zhao, Dian Wu, Mingxia Li, Yuming Mu

Journal: Mol Med Rep

PubMed ID: 34328190

Doi: 10.3892/mmr.2021.12327

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Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models

Authors: Dinesh Kumar Verma, Bo Am Seo, Anurupa Ghosh, Shi-Xun Ma, Karina Hernandez-Quijada, Julie K Andersen, Han Seok Ko, Yong-Hwan Kim

Journal: Cells

PubMed ID: 34359864

Doi: 10.3390/cells10071694

Products & Services: Nucleic Acid Purification & Analysis

LINC00667 Promotes Progression of Esophageal Cancer Cells by Regulating miR-200b-3p/SLC2A3 Axis

Authors: Jindun Pan, Yunhong Zang

Journal: Dig Dis Sci

PubMed ID: 34313922

Doi: 10.1007/s10620-021-07145-5

Products & Services: Mutant Libraries

Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation

Authors: Lanzhen Li, Zhongcheng Gao, Lei Zhao, Peiyou Ren, Hongyan Shen

Journal: J Cell Mol Med

PubMed ID: 34232553

Doi: 10.1111/jcmm.16265

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Immunological studies on chicken interferon-kappa using an antigen-capture ELISA developed using new mouse monoclonal antibodies

Authors: Youngsub Lee, Mingmin Lu, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 34271063

Doi: 10.1016/j.dci.2021.104204

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Characterization of CRISPR array in Salmonella enterica from asymptomatic people and patients

Authors: Kai Zhang, Yue Zhang, Zhenyu Wang, Yang Li, Haiyan Xu, Xinan Jiao, Qiuchun Li

Journal: Int J Food Microbiol

PubMed ID: 34333443

Doi: 10.1016/j.ijfoodmicro.2021.109338

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Effect of Hydrophobicity and Charge Separation on the Antifouling Properties of Surface-Tethered Zwitterionic Peptides

Authors: Chuanxi Li, Minglun Li, Wei Qi, Rongxin Su, Jing Yu

Journal: Langmuir

PubMed ID: 34228454

Doi: 10.1021/acs.langmuir.1c00803

Products & Services: DNA Sequencing

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

Authors: Qifei Li , Michal Dibus , Alicia Casey , Christina S K Yee , Sara O Vargas , Shiyu Luo , Samantha M Rosen, Jill A Madden , Casie A Genetti , Jan Brabek , Catherine A Brownstein , Shideh Kazerounian, Benjamin A Raby , Klaus Schmitz-Abe , John C Kennedy, Martha P Fishman, Mary P Mullen, Joan M Taylor, Daniel Rosel, Pankaj B Agrawal

Journal: PLoS Genet

PubMed ID: 34232960

Doi: 10.1371/journal.pgen.1009639

Products & Services: Mammalian Expression

Eugenol interacts with cardiac sodium channel and reduces heart excitability and arrhythmias

Authors: Jorge Lucas Teixeira-Fonseca, Artur Santos-Miranda, Joab Barbosa da Silva, Leisiane Pereira Marques, Julliane Vasconcelos Joviano-Santos, Paula Idma Chaves Nunes, Danilo Roman-Campos, Antonio Nei Santana Gondim

Journal: Life Sci

PubMed ID: 34217764

Doi: 10.1016/j.lfs.2021.119761

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Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest

Authors: Ai-Hua Wu, Xu-Long Chen, Long-Yi Guo, Dong-Fang Lu, Shan Lu, Ai-Ai Wang, Xue-Fang Liang

Journal: Reprod Biomed Online

PubMed ID: 34474977

Doi: 10.1016/j.rbmo.2021.06.023

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Engineering Concanavalin B to Release Bioactive Peptides against Metabolic Syndrome

Authors: Diego Armando Maldonado-Torres, G Janet Jara-Romero, Flor de Fátima Rosas-Cárdenas, D Alejandro Fernández-Velasco, Silvia Luna-Suárez

Journal: Foods

PubMed ID: 34359424

Doi: 10.3390/foods10071554

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Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses

Authors: Dessislava Malinova, Laabiah Wasim, Rebecca Newman, Ana Martínez-Riaño, Niklas Engels, Pavel Tolar

Journal: EMBO Rep

PubMed ID: 34323351

Doi: 10.15252/embr.202051328

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

Authors: Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G Tikhonova, Eoin M Scanlan, Vincent Olieric, Martin Caffrey

Journal: Nat Commun

PubMed ID: 34253723

Doi: 10.1038/s41467-021-24475-0

Products & Services: Bacterial Expression

A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary

Authors: K Yeon Choi, Alistair McGregor

Journal: Viruses

PubMed ID: 34452332

Doi: 10.3390/v13081467

Products & Services: Mutant Libraries

Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from

Authors: Hannah Valentino, David A Korasick, Tabbetha J Bohac, Justin A Shapiro, Timothy A Wencewicz, John J Tanner, Pablo Sobrado

Journal: ACS Omega

PubMed ID: 34308084

Doi: 10.1021/acsomega.1c03047

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Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection

Authors: Joanne Marie M Del Rosario, Kelly A S da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A Wells, Gurdip Singh Mann, Veronica O Ameh, Claude T Sabeta, Ashley C Banyard, Rebecca Kinsley, Simon D Scott, Ralf Wagner, Jonathan L Heeney, George W Carnell, Nigel J Temperton

Journal: Vaccines (Basel)

PubMed ID: 34358157

Doi: 10.3390/vaccines9070741

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VC1 catalyses a key step in the biosynthesis of vicine in faba bean

Authors: Emilie Björnsdotter, Marcin Nadzieja, Wei Chang, Leandro Escobar-Herrera, Davide Mancinotti, Deepti Angra, Xinxing Xia, Rebecca Tacke, Hamid Khazaei, Christoph Crocoll, Albert Vandenberg, Wolfgang Link, Frederick L Stoddard, Donal M O'Sullivan, Jens Stougaard, Alan H Schulman, Stig U Andersen, Fernando Geu-Flores

Journal: Nat Plants

PubMed ID: 34226693

Doi: 10.1038/s41477-021-00950-w

Products & Services: Bacterial Expression

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission

Authors: Zhenke Yang, Yang Shi, Huiting Cui, Shuzhen Yang, Han Gao, Jing Yuan

Journal: Sci Adv

PubMed ID: 34301597

Doi: 10.1126/sciadv.abf6015

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

Authors: Juan Zhao, Ling Wang, Madison Schank, Xindi Dang, Zeyuan Lu, Dechao Cao, Sushant Khanal, Lam N Nguyen, Lam N T Nguyen, Jinyu Zhang, Yi Zhang, James L Adkins, Evan M Baird, Xiao Y Wu, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao

Journal: Virus Res

PubMed ID: 34329696

Doi: 10.1016/j.virusres.2021.198508

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Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

Authors: Nguyen Van Vinh Chau, Le Nguyen Thanh Nhan, Lam Anh Nguyet, Nguyen Thi Kha Tu, Nguyen Thi Thu Hong, Dinh Nguyen Huy Man, Dinh Thi Bich Ty, Le Nguyen Truc Nhu, Lam Minh Yen, Truong Huu Khanh, Du Tuan Quy, Ngo Ngoc Quang Minh, Nguyen Thi Han Ny, Danielle Anderson, Lin-Fa Wang, H Rogier van Doorn, Nguyen Thanh Hung, Tran Tan Thanh, Guy Thwaites, Le Van Tan

Journal: Int J Infect Dis

PubMed ID: 34339862

Doi: 10.1016/j.ijid.2021.07.072

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WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

Authors: Chunwan Lu, Zhuoqi Liu, John D Klement, Dafeng Yang, Alyssa D Merting, Dakota Poschel, Thomas Albers, Jennifer L Waller, Huidong Shi, Kebin Liu

Journal: J Immunother Cancer

PubMed ID: 34326167

Doi: 10.1136/jitc-2021-002624

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Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury

Authors: Evgeny A Zemskov, Xiaomin Wu, Saurabh Aggarwal, Mannivannan Yegambaram, Christine Gross, Qing Lu, Hui Wang, Haiyang Tang, Ting Wang, Stephen M Black

Journal: J Biol Chem

PubMed ID: 34252457

Doi: 10.1016/j.jbc.2021.100946

Products & Services: Mammalian Expression

Molecular characterization and functional analysis of Trx and Trp14 in roughskin sculpin (Trachidermus fasciatus)

Authors: Yingying Liu, Jinmiao Zhong, Lihua Zhao, Shanshan Yu, Haidong Zha, Yingmei Chai, Qian Zhu

Journal: Fish Physiol Biochem

PubMed ID: 34279744

Doi: 10.1007/s10695-021-00978-x

Products & Services: Proteins, Expression, Isolation and Analysis

Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization

Authors: Ariana D Sanchez, Tess C Branon, Lauren E Cote, Alexandros Papagiannakis, Xing Liang, Melissa A Pickett, Kang Shen, Christine Jacobs-Wagner, Alice Y Ting, Jessica L Feldman

Journal: Curr Biol

PubMed ID: 34242576

Doi: 10.1016/j.cub.2021.06.021

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Annexin A1 Tripeptide Mimetic Increases Sirtuin-3 and Augments Mitochondrial Function to Limit Ischemic Kidney Injury

Authors: Hagir Suliman, Qing Ma, Zhiquan Zhang, Jiafa Ren, Benjamin T Morris, Steven D Crowley, Luis Ulloa, Jamie R Privratsky

Journal: Front Physiol

PubMed ID: 34276404

Doi: 10.3389/fphys.2021.683098

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Comparison of promoter, DNA vector, and cationic carrier for efficient transfection of hMSCs from multiple donors and tissue sources

Authors: Tyler Kozisek, Andrew Hamann, Luke Samuelson, Miguel Fudolig, Angela K Pannier

Journal: Mol Ther Nucleic Acids

PubMed ID: 34513295

Doi: 10.1016/j.omtn.2021.06.018

Products & Services: Recombinant Proteins

Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors

Authors: Maira Zorzan, Claudia Del Vecchio, Stefania Vogiatzis, Elisa Saccon, Cristina Parolin, Giorgio Palù, Arianna Calistri, Carla Mucignat-Caretta

Journal: Viruses

PubMed ID: 34372567

Doi: 10.3390/v13071361

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Kinetics of Anti-SARS-CoV-2 Antibody Responses 3 Months Post Complete Vaccination with BNT162b2; A Prospective Study in 283 Health Workers

Authors: Evangelos Terpos, Ioannis P Trougakos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Sentiljana Gumeni, Filia Apostolakou, Aimilia D Sklirou, Maria Gavriatopoulou, Stamatia Skourti, Efstathios Kastritis, Eleni Korompoki, Ioannis Papassotiriou, Meletios A Dimopoulos

Journal: Cells

PubMed ID: 34440710

Doi: 10.3390/cells10081942

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation

Authors: Zhenzi Su Aidi Gao, Xiaoqing Li, Shitao Zou, Chao He, Jinchang Wu, Wei-Qun Ding, Jundong Zhou

Journal: Front Oncol.

PubMed ID: 34354953

Doi: 10.3389/fonc.2021.706337

Products & Services: Proteins, Expression, Isolation and Analysis

Genetic engineering of Treponema pallidum subsp pallidum, the Syphilis Spirochete

Authors: Emily Romeis, Lauren Tantalo, Nicole Lieberman, Quynh Phung, Alex Greninger, Lorenzo Giacani

Journal: PLoS Pathog

PubMed ID: 34228757

Doi: 10.1371/journal.ppat.1009612

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The RNA editing enzyme ADAR2 restricts L1 mobility

Authors: Loredana Frassinelli, Elisa Orecchini, Sofian Al-Wardat, Marco Tripodi, Carmine Mancone, Margherita Doria, Silvia Galardi, Silvia Anna Ciafrè, Alessandro Michienzi

Journal: RNA Biol

PubMed ID: 34224323

Doi: 10.1080/15476286.2021.1940020

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Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

Authors: Robert Reiberger, Kateřina Radilová, Michal Kráľ, Václav Zima, Pavel Majer, Jiří Brynda, Martin Dračínský, Jan Konvalinka, Milan Kožíšek, Aleš Machara

Journal: Int J Mol Sci

PubMed ID: 34299354

Doi: 10.3390/ijms22147735

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LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

Authors: Zhen Sun, Hua Yu, Jing Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Bo Gao, Longfei Wang, Cristina Correia, Ming Chen, Qiming Sun, Yu Feng, Li Shen, Hao Wu, Jianlong Wang, Xiaohua Shen, George Q Daley, Hu Li, Jin Zhang

Journal: Protein Cell

PubMed ID: 34331666

Doi: 10.1007/s13238-021-00864-5

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An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions

Authors: Alex J Clark, Umaiyal Kugathasan, Georgios Baskozos, David A Priestman, Nadine Fugger, Museer A Lone, Alaa Othman, Ka Hing Chu, Iulia Blesneac, Emma R Wilson, Matilde Laurà, Bernadett Kalmar, Linda Greensmith, Thorsten Hornemann, Frances M Platt, Mary M Reilly, David L Bennett

Journal: Cell Rep Med

PubMed ID: 34337561

Doi: 10.1016/j.xcrm.2021.100345

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Assessing the antigenicity of different VP3 regions of infectious bursal disease virus in chickens from South Brazil

Authors: Ana Paula Gori Palka, Tatiana Reichert Assunção de Matos, Claudemir de Souza, Danilo Santos Eugênio, Marco Aurélio Krieger, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: BMC Vet Res

PubMed ID: 34330285

Doi: 10.1186/s12917-021-02956-0

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Analysis of Evolution, Expression and Genetic Transformation of TCP Transcription Factors in Blueberry Reveal That Negatively Regulates the Release of Flower Bud Dormancy

Authors: Yongqiang Li, Shuang An, Qiangqiang Cheng, Yu Zong, Wenrong Chen, Weidong Guo, Lu Zhang

Journal: Front Plant Sci

PubMed ID: 34305986

Doi: 10.3389/fpls.2021.697609

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Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Authors: Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic, Verena Siewers

Journal: Microb Cell Fact

PubMed ID: 34261490

Doi: 10.1186/s12934-021-01624-0

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Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori

Authors: Leah F Rosin, Jose Gil, Ines A Drinnenberg, Elissa P Lei

Journal: PLoS Genet

PubMed ID: 34319984

Doi: 10.1371/journal.pgen.1009700

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The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function

Authors: Sarah F Ruidiaz, Jesper E Dreier, Rasmus Hartmann-Petersen, Birthe B Kragelund

Journal: Protein Sci

PubMed ID: 34272906

Doi: 10.1002/pro.4159

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Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides

Authors: Lawrence M Schopfer, Seda Onder, Oksana Lockridge

Journal: PLoS ONE

PubMed ID: 34242352

Doi: 10.1371/journal.pone.0254450

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Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells

Authors: Sara Artigas-Jerónimo, Margarita Villar, Agustín Estrada-Peña, Adrián Velázquez-Campoy, Pilar Alberdi, José de la Fuente

Journal: Biosci Rep

PubMed ID: 34291801

Doi: 10.1042/BSR20211120

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SARS-CoV-2 Neutralizing Antibody Responses towards Full-Length Spike Protein and the Receptor-Binding Domain

Authors: Rafael Bayarri-Olmos, Manja Idorn, Anne Rosbjerg, Laura Pérez-Alós, Cecilie Bo Hansen, Laust Bruun Johnsen, Charlotte Helgstrand, Franziska Zosel, Jais Rose Bjelke, Fredrik Kryh Öberg, Max Søgaard, Søren R Paludan, Theresa Bak-Thomsen, Joseph G Jardine, Mikkel-Ole Skjoedt, Peter Garred

Journal: J Immunol

PubMed ID: 34301847

Doi: 10.4049/jimmunol.2100272

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

Authors: Tess R Malcolm, Karolina W Swiderska, Brooke K Hayes, Chaille T Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan

Journal: Biochem J

PubMed ID: 34133730

Doi: 10.1042/BCJ20210172

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Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

Authors: Tess R Malcolm, Karolina W Swiderska, Brooke K Hayes, Chaille T Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan

Journal: Biochem J

PubMed ID: 34133730

Doi: 10.1042/BCJ20210172

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nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Authors: Laura Sandra Lello, Koen Bartholomeeusen, Sainan Wang, Sandra Coppens, Rennos Fragkoudis, Luke Alphey, Kevin K Ariën, Andres Merits, Age Utt

Journal: J Virol

PubMed ID: 34319783

Doi: 10.1128/JVI.00355-21

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Generation and characterization of self-assembled protein nanocages based on β-carboxysomes in Escherichia coli

Authors: Ruimin Gao, Xian-En Zhang, Feng Li

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 34009253

Doi: 10.1093/abbs/gmab064

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Inhibition of suppressor of cytokine signaling-3 affects mesangial cell proliferation and cell cycle in mesangioproliferative glomerulonephritis

Authors: Min Liu, Ya-Chao Wang, Jun Zhou

Journal: Kaohsiung J Med Sci

PubMed ID: 34213074

Doi: 10.1002/kjm2.12415

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A Collaborative Partnership between the Multicenter Handoff Collaborative and an Electronic Health Record Vendor

Authors: Bommy Hong Mershon, Andrea Vannucci, Trent Bryson, Felix Lin, Philip E Greilich, Guy Dear, Patrick Guffey, Aalok Agarwala

Journal: Appl Clin Inform

PubMed ID: 34320682

Doi: 10.1055/s-0041-1731714

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Chemical-genetic CRISPR-Cas9 screens in human cells using a pathway-specific library

Authors: Frances V Hundley, David P Toczyski

Journal: STAR Protoc

PubMed ID: 34382013

Doi: 10.1016/j.xpro.2021.100685

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Douglas-fir () is an active transcription factor during zygotic and somatic embryogenesis

Authors: Mariana A Vetrici, Dmytro P Yevtushenko, Santosh Misra

Journal: Plant Direct

PubMed ID: 34355111

Doi: 10.1002/pld3.333

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STING Agonist Combined to a Protein-Based Cancer Vaccine Potentiates Peripheral and Intra-Tumoral T Cell Immunity

Authors: Matteo Rossi, Susanna Carboni, Wilma Di Berardino-Besson, Erika Riva, Marie-Laure Santiago-Raber, Elodie Belnoue, Madiha Derouazi

Journal: Front Immunol

PubMed ID: 34276686

Doi: 10.3389/fimmu.2021.695056

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Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity

Authors: Kirsten M Baecher, Mandy L Ford

Journal: Cancer Immunol Immunother

PubMed ID: 34241677

Doi: 10.1007/s00262-021-03004-4

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Therapeutic siRNAs targeting JAK/STAT signalling pathway in inflammatory bowel diseases

Authors: Flora Clément, Adrien Nougarède, Stéphanie Combe, Frédérique Kermarrec, Arindam K Dey, Patricia Obeid, Fabrice P Navarro, Patrice N Marche, Eric Sulpice, Xavier Gidrol

Journal: J Crohns Colitis

PubMed ID: 34286840

Doi: 10.1093/ecco-jcc/jjab129

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Investigating the Efficiency of Recombinant FliC-Loaded Spores in Mice Immunization against Serovar Typhi

Authors: Nafiseh Ghorbani, Mehdi Assmar, Nour Amirmozafari, Khosrow Issazadeh

Journal: Iran J Public Health

PubMed ID: 34568187

Doi: 10.18502/ijph.v50i7.6638

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sRAGE downregulates the VEGF expression in OHSS ovarian granulosa cells

Authors: Bijun Wang, Jingyan Wang, Yi Liu, Liang Wang, Mingze Du, Zhan Zhang, Yichun Guan

Journal: Gynecol Endocrinol

PubMed ID: 34223781

Doi: 10.1080/09513590.2021.1942453

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Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

Authors: Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, Matthew Angel, Jenifer Bear, Dimitris Stellas, Sevasti Karaliota, Filia Apostolakou, Tina Bagratuni, Dimitris Patseas, Sentiljana Gumeni, Ioannis P Trougakos, Meletios A Dimopoulos, Barbara K Felber, George N Pavlakis

Journal: Cell Rep

PubMed ID: 34352226

Doi: 10.1016/j.celrep.2021.109504

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Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

Authors: Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, C Anders Olson, Shivani Mody, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong

Journal: Sci Rep

PubMed ID: 34290317

Doi: 10.1038/s41598-021-94364-5

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Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy

Authors: Qingyun Yuan, Qiaoyan Liang, Zujun Sun, Xingxing Yuan, Weihua Hou, Yuxiong Wang, Huijie Wang, Min Yu

Journal: Oncoimmunology

PubMed ID: 34350059

Doi: 10.1080/2162402X.2021.1914954

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Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers

Authors: Chandima Jeewandara, Achala Kamaladasa, Pradeep Darshana Pushpakumara, Deshni Jayathilaka, Inoka Sepali Aberathna, Danasekara Rallage Saubhagya Rasikangani Danasekara, Dinuka Guruge, Thushali Ranasinghe, Shashika Dayarathna, Thilagaraj Pathmanathan, Gayasha Somathilake, Panambara Arachchige Deshan Madhusanka, Shyrar Tanussiya Ramu, Tibutius Thanesh Pramanayagam Jayadas, Heshan Kuruppu, Ayesha Wijesinghe, Herath Mudiyanselage Thashmi Nimasha, Dushantha Milroy, Achini Anuja Nandasena, Poththawela Kankanam Gamage Nilanka Sanjeewani, Ruwan Wijayamuni, Sudath Samaraweera, Lisa Schimanski, T K Tan, Tao Dong, Graham S Ogg, Alain Townsend, Gathsaurie Neelika Malavige

Journal: Nat Commun

PubMed ID: 34326317

Doi: 10.1038/s41467-021-24579-7

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Molecular characterization and functional analysis of IL-18 in snakehead (Channa argus) during Aeromonas schubertii and Nocardia seriolae infections

Authors: Zheng-Wei Cui, Dong-Qi Li, Fei Zhao, Ai-Ping Tan, Yu-Ting Deng, Ying-Tiao Lai, Zhi-Bin Huang, Lan Jiang

Journal: Mol Immunol

PubMed ID: 34280771

Doi: 10.1016/j.molimm.2021.07.013

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FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Authors: Antonio Porro, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, Giulio Collotta, Keri M Fishwick, Nour L Mozaffari, Raphaël Guérois, Josef Jiricny, Matthias Altmeyer, Jean-Baptiste Charbonnier, Christopher E Pearson, Alessandro A Sartori

Journal: Sci Adv

PubMed ID: 34330701

Doi: 10.1126/sciadv.abf7906

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Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain

Authors: XiaoLuan Xu, AnQi Ma, TieSong Li, WenXue Cui, XueFeng Wang, Jun Li, Qingwei Li, Yue Pang

Journal: Front Cell Dev Biol

PubMed ID: 34277616

Doi: 10.3389/fcell.2021.674939

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Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates

Authors: Alireza Hassani Najafabadi, Zeynab Izadi Najaf Abadi, Marisa E Aikins, Kathryn E Foulds, Mitzi M Donaldson, Wenmin Yuan, Emeka B Okeke, Jutaek Nam, Yao Xu, Priyan Weerappuli, Taryn Hetrick, David Adams, Patrick A Lester, Andres M Salazar, Dan H Barouch, Anna Schwendeman, Robert A Seder, James J Moon

Journal: J Control Release

PubMed ID: 34280415

Doi: 10.1016/j.jconrel.2021.07.026

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Silver carp scale gelatins for the stabilization of fish oil-loaded emulsions

Authors: Jiamin Xu, Ting Zhang, Yangyi Zhang, Lili Yang, Yinghua Nie, Ningping Tao, Xichang Wang, Jian Zhong

Journal: Int J Biol Macromol

PubMed ID: 34246667

Doi: 10.1016/j.ijbiomac.2021.07.043

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Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice

Authors: Meiqin Zhang, Sichen Du, Huayuan Ou, Renjie Cui, Nan Jiang, Yifeng Lin, Runsheng Ge, Duan Ma, Jin Zhang

Journal: J Mol Cell Biol

PubMed ID: 33475140

Doi: 10.1093/jmcb/mjaa081

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Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Authors: Nicholas A Vitanza, Adam J Johnson, Ashley L Wilson, Christopher Brown, Jason K Yokoyama, Annette Künkele, Cindy A Chang, Stephanie Rawlings-Rhea, Wenjun Huang, Kristy Seidel, Catherine M Albert, Navin Pinto, Juliane Gust, Laura S Finn, Jeffrey G Ojemann, Jason Wright, Rimas J Orentas, Michael Baldwin, Rebecca A Gardner, Michael C Jensen, Julie R Park

Journal: Nat Med

PubMed ID: 34253928

Doi: 10.1038/s41591-021-01404-8

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Nitric Oxide Functions as a Downstream Signal for Melatonin-Induced Cold Tolerance in Cucumber Seedlings

Authors: Yiqing Feng, Xin Fu, Lujie Han, Chenxiao Xu, Chaoyue Liu, Huangai Bi, Xizhen Ai

Journal: Front Plant Sci

PubMed ID: 34367212

Doi: 10.3389/fpls.2021.686545

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From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape

Authors: Chiranjib Chakraborty, Ashish Ranjan Sharma, Manojit Bhattacharya, Sang-Soo Lee

Journal: Front Immunol

PubMed ID: 34305909

Doi: 10.3389/fimmu.2021.679344

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Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

Authors: Qian Chen, Yuyan Liu, Jiping Ren, Panpan Zhong, Manni Chen, Dongsheng Jia, Hongyan Chen, Taiyun Wei

Journal: Elife

PubMed ID: 34214032

Doi: 10.7554/eLife.64603

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LYSMD3: A mammalian pattern recognition receptor for chitin

Authors: Xin He, Brad A Howard, Yang Liu, Aaron K Neumann, Liwu Li, Nidhi Menon, Tiffany Roach, Shiv D Kale, David C Samuels, Hongyan Li, Trenton Kite, Hirohito Kita, Tony Y Hu, Mengyao Luo, Caroline N Jones, Uju Joy Okaa, Diane L Squillace, Bruce S Klein, Christopher B Lawrence

Journal: Cell Rep

PubMed ID: 34289364

Doi: 10.1016/j.celrep.2021.109392

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Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis

Authors: Kexin Zhu, Dong Yu, Jiahui An, Yufeng Li

Journal: Vet Res

PubMed ID: 34225787

Doi: 10.1186/s13567-021-00967-1

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Preerythrocytic Vaccine Antigens Enhance Sterile Protection in Mice Induced by Circumsporozoite Protein

Authors: Shaji Daniel, Alexander Pichugin, Holly Torano, Jonathan P Renn, Jennifer Kwan, Matthew V Cowles, Solomon Conteh, Lynn E Lambert, Nada Alani, Nicholas J MacDonald, Weili Dai, Kendrick Highsmith, Charles Anderson, J Patrick Gorres, Javonn Musgrove, Brandi Butler, Nouf Althubaiti, Saurabh Dixit, Stasya Zarling-Bejma, Urszula Krzych, Patrick E Duffy

Journal: Infect Immun

PubMed ID: 34310889

Doi: 10.1128/IAI.00165-21

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Host-emitted amino acid cues regulate bacterial chemokinesis to enhance colonization

Authors: Catherine D Robinson, Emily G Sweeney, Julia Ngo, Emily Ma, Arden Perkins, T Jarrod Smith, Nicolas L Fernandez, Christopher M Waters, S James Remington, Brendan J M Bohannan, Karen Guillemin

Journal: Cell Host Microbe

PubMed ID: 34233153

Doi: 10.1016/j.chom.2021.06.003

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Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

Authors: Seth H Pincus, Ryan B Craig, Lauren Weachter, Celia C LaBranche, Rafiq Nabi, Connie Watt, Mark Raymond, Tami Peters, Kejing Song, Grace A Maresh, David C Montefiori, Pamela A Kozlowski

Journal: Vaccines (Basel)

PubMed ID: 34358190

Doi: 10.3390/vaccines9070774

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Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals

Authors: Tomohiro Suzuki, Mayuko Hayashi, Tetsuro Komatsu, Akiko Tanioka, Masahiro Nagasawa, Kyoko Tanimura-Inagaki, Mohammad Sharifur Rahman, Shinnosuke Masuda, Kosuke Yusa, Juro Sakai, Hiroshi Shibata, Takeshi Inagaki

Journal: Endocr J

PubMed ID: 34261826

Doi: 10.1507/endocrj.EJ21-0255

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