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A Collaborative Partnership between the Multicenter Handoff Collaborative and an Electronic Health Record Vendor

Authors: Bommy Hong Mershon, Andrea Vannucci, Trent Bryson, Felix Lin, Philip E Greilich, Guy Dear, Patrick Guffey, Aalok Agarwala

Journal: Appl Clin Inform

PubMed ID: 34320682

Doi: 10.1055/s-0041-1731714

Products & Services: Oligo pool

Chemical-genetic CRISPR-Cas9 screens in human cells using a pathway-specific library

Authors: Frances V Hundley, David P Toczyski

Journal: STAR Protoc

PubMed ID: 34382013

Doi: 10.1016/j.xpro.2021.100685

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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Authors: Lingshu Wang, Tongqing Zhou, Yi Zhang, Eun Sung Yang, Chaim A Schramm, Wei Shi, Amarendra Pegu, Olamide K Oloninyi, Amy Ransier, Samuel Darko, Sandeep R Narpala, Christian Hatcher, David R Martinez, Yaroslav Tsybovsky, Emily Phung, Olubukola M Abiona, Evan M Cale, Lauren A Chang, Kizzmekia S Corbett, Anthony T DiPiazza, Ingelise J Gordon, Kwanyee Leung, Tracy Liu, Rosemarie D Mason, Alexandra Nazzari, Laura Novik, Adam S Olia, Tyler Stephens, Christopher D Stringham, Chloe Adrienna Talana, I-Ting Teng, Danielle Wagner, Alicia T Widge, Baoshan Zhang, Mario Roederer, Julie E Ledgerwood, Tracy J Ruckwardt, Martin R Gaudinski, Ralph S Baric, Barney S Graham, Adrian B McDermott, Daniel C Douek, Peter D Kwong, John R Mascola, Nancy J Sullivan, John Misasi

Journal: Science

PubMed ID: 33655252

Doi: 10.1126/science.abh1766

Products & Services: Codon Optimization

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

Authors: Kanchan Devkota, Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Pegah Ghiabi, Taraneh Hajian, Peter Loppnau, Albina Bolotokova, Karla J F Satchell, Ke Wang, Deyao Li, Jing Liu, David Smil, Minkui Luo, Jian Jin, Paul V Fish, Peter J Brown, Masoud Vedadi

Journal: SLAS Discov

PubMed ID: 34192965

Doi: 10.1177/24725552211026261

Products & Services: Peptide Synthesis

Douglas-fir () is an active transcription factor during zygotic and somatic embryogenesis

Authors: Mariana A Vetrici, Dmytro P Yevtushenko, Santosh Misra

Journal: Plant Direct

PubMed ID: 34355111

Doi: 10.1002/pld3.333

Products & Services: Peptide Synthesis

STING Agonist Combined to a Protein-Based Cancer Vaccine Potentiates Peripheral and Intra-Tumoral T Cell Immunity

Authors: Matteo Rossi, Susanna Carboni, Wilma Di Berardino-Besson, Erika Riva, Marie-Laure Santiago-Raber, Elodie Belnoue, Madiha Derouazi

Journal: Front Immunol

PubMed ID: 34276686

Doi: 10.3389/fimmu.2021.695056

Products & Services: Bacterial Expression

Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity

Authors: Kirsten M Baecher, Mandy L Ford

Journal: Cancer Immunol Immunother

PubMed ID: 34241677

Doi: 10.1007/s00262-021-03004-4

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Therapeutic siRNAs targeting JAK/STAT signalling pathway in inflammatory bowel diseases

Authors: Flora Clément, Adrien Nougarède, Stéphanie Combe, Frédérique Kermarrec, Arindam K Dey, Patricia Obeid, Fabrice P Navarro, Patrice N Marche, Eric Sulpice, Xavier Gidrol

Journal: J Crohns Colitis

PubMed ID: 34286840

Doi: 10.1093/ecco-jcc/jjab129

Products & Services: Gene Synthesis

Investigating the Efficiency of Recombinant FliC-Loaded Spores in Mice Immunization against Serovar Typhi

Authors: Nafiseh Ghorbani, Mehdi Assmar, Nour Amirmozafari, Khosrow Issazadeh

Journal: Iran J Public Health

PubMed ID: 34568187

Doi: 10.18502/ijph.v50i7.6638

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sRAGE downregulates the VEGF expression in OHSS ovarian granulosa cells

Authors: Bijun Wang, Jingyan Wang, Yi Liu, Liang Wang, Mingze Du, Zhan Zhang, Yichun Guan

Journal: Gynecol Endocrinol

PubMed ID: 34223781

Doi: 10.1080/09513590.2021.1942453

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Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

Authors: Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, Matthew Angel, Jenifer Bear, Dimitris Stellas, Sevasti Karaliota, Filia Apostolakou, Tina Bagratuni, Dimitris Patseas, Sentiljana Gumeni, Ioannis P Trougakos, Meletios A Dimopoulos, Barbara K Felber, George N Pavlakis

Journal: Cell Rep

PubMed ID: 34352226

Doi: 10.1016/j.celrep.2021.109504

Products & Services: Serology SARS-Cov-2 detection kits

Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

Authors: Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, C Anders Olson, Shivani Mody, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong

Journal: Sci Rep

PubMed ID: 34290317

Doi: 10.1038/s41598-021-94364-5

Products & Services: Serology SARS-Cov-2 detection kits

Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy

Authors: Qingyun Yuan, Qiaoyan Liang, Zujun Sun, Xingxing Yuan, Weihua Hou, Yuxiong Wang, Huijie Wang, Min Yu

Journal: Oncoimmunology

PubMed ID: 34350059

Doi: 10.1080/2162402X.2021.1914954

Products & Services: Recombinant Proteins

Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers

Authors: Chandima Jeewandara, Achala Kamaladasa, Pradeep Darshana Pushpakumara, Deshni Jayathilaka, Inoka Sepali Aberathna, Danasekara Rallage Saubhagya Rasikangani Danasekara, Dinuka Guruge, Thushali Ranasinghe, Shashika Dayarathna, Thilagaraj Pathmanathan, Gayasha Somathilake, Panambara Arachchige Deshan Madhusanka, Shyrar Tanussiya Ramu, Tibutius Thanesh Pramanayagam Jayadas, Heshan Kuruppu, Ayesha Wijesinghe, Herath Mudiyanselage Thashmi Nimasha, Dushantha Milroy, Achini Anuja Nandasena, Poththawela Kankanam Gamage Nilanka Sanjeewani, Ruwan Wijayamuni, Sudath Samaraweera, Lisa Schimanski, T K Tan, Tao Dong, Graham S Ogg, Alain Townsend, Gathsaurie Neelika Malavige

Journal: Nat Commun

PubMed ID: 34326317

Doi: 10.1038/s41467-021-24579-7

Products & Services: Recombinant Antibody Expression

Molecular characterization and functional analysis of IL-18 in snakehead (Channa argus) during Aeromonas schubertii and Nocardia seriolae infections

Authors: Zheng-Wei Cui, Dong-Qi Li, Fei Zhao, Ai-Ping Tan, Yu-Ting Deng, Ying-Tiao Lai, Zhi-Bin Huang, Lan Jiang

Journal: Mol Immunol

PubMed ID: 34280771

Doi: 10.1016/j.molimm.2021.07.013

Products & Services: Recombinant Antibody Expression

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Authors: Antonio Porro, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, Giulio Collotta, Keri M Fishwick, Nour L Mozaffari, Raphaël Guérois, Josef Jiricny, Matthias Altmeyer, Jean-Baptiste Charbonnier, Christopher E Pearson, Alessandro A Sartori

Journal: Sci Adv

PubMed ID: 34330701

Doi: 10.1126/sciadv.abf7906

Products & Services: Recombinant Antibody Expression

Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain

Authors: XiaoLuan Xu, AnQi Ma, TieSong Li, WenXue Cui, XueFeng Wang, Jun Li, Qingwei Li, Yue Pang

Journal: Front Cell Dev Biol

PubMed ID: 34277616

Doi: 10.3389/fcell.2021.674939

Products & Services: Recombinant Antibody Expression

Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates

Authors: Alireza Hassani Najafabadi, Zeynab Izadi Najaf Abadi, Marisa E Aikins, Kathryn E Foulds, Mitzi M Donaldson, Wenmin Yuan, Emeka B Okeke, Jutaek Nam, Yao Xu, Priyan Weerappuli, Taryn Hetrick, David Adams, Patrick A Lester, Andres M Salazar, Dan H Barouch, Anna Schwendeman, Robert A Seder, James J Moon

Journal: J Control Release

PubMed ID: 34280415

Doi: 10.1016/j.jconrel.2021.07.026

Products & Services: Proteins, Expression, Isolation and Analysis

Silver carp scale gelatins for the stabilization of fish oil-loaded emulsions

Authors: Jiamin Xu, Ting Zhang, Yangyi Zhang, Lili Yang, Yinghua Nie, Ningping Tao, Xichang Wang, Jian Zhong

Journal: Int J Biol Macromol

PubMed ID: 34246667

Doi: 10.1016/j.ijbiomac.2021.07.043

Products & Services: Proteins, Expression, Isolation and Analysis

Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice

Authors: Meiqin Zhang, Sichen Du, Huayuan Ou, Renjie Cui, Nan Jiang, Yifeng Lin, Runsheng Ge, Duan Ma, Jin Zhang

Journal: J Mol Cell Biol

PubMed ID: 33475140

Doi: 10.1093/jmcb/mjaa081

Products & Services: Proteins, Expression, Isolation and Analysis

Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Authors: Nicholas A Vitanza, Adam J Johnson, Ashley L Wilson, Christopher Brown, Jason K Yokoyama, Annette Künkele, Cindy A Chang, Stephanie Rawlings-Rhea, Wenjun Huang, Kristy Seidel, Catherine M Albert, Navin Pinto, Juliane Gust, Laura S Finn, Jeffrey G Ojemann, Jason Wright, Rimas J Orentas, Michael Baldwin, Rebecca A Gardner, Michael C Jensen, Julie R Park

Journal: Nat Med

PubMed ID: 34253928

Doi: 10.1038/s41591-021-01404-8

Products & Services: Proteins, Expression, Isolation and Analysis

Nitric Oxide Functions as a Downstream Signal for Melatonin-Induced Cold Tolerance in Cucumber Seedlings

Authors: Yiqing Feng, Xin Fu, Lujie Han, Chenxiao Xu, Chaoyue Liu, Huangai Bi, Xizhen Ai

Journal: Front Plant Sci

PubMed ID: 34367212

Doi: 10.3389/fpls.2021.686545

Products & Services: Proteins, Expression, Isolation and Analysis

From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape

Authors: Chiranjib Chakraborty, Ashish Ranjan Sharma, Manojit Bhattacharya, Sang-Soo Lee

Journal: Front Immunol

PubMed ID: 34305909

Doi: 10.3389/fimmu.2021.679344

Products & Services: Proteins, Expression, Isolation and Analysis

Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

Authors: Qian Chen, Yuyan Liu, Jiping Ren, Panpan Zhong, Manni Chen, Dongsheng Jia, Hongyan Chen, Taiyun Wei

Journal: Elife

PubMed ID: 34214032

Doi: 10.7554/eLife.64603

Products & Services: Polyclonal Antibody Services

LYSMD3: A mammalian pattern recognition receptor for chitin

Authors: Xin He, Brad A Howard, Yang Liu, Aaron K Neumann, Liwu Li, Nidhi Menon, Tiffany Roach, Shiv D Kale, David C Samuels, Hongyan Li, Trenton Kite, Hirohito Kita, Tony Y Hu, Mengyao Luo, Caroline N Jones, Uju Joy Okaa, Diane L Squillace, Bruce S Klein, Christopher B Lawrence

Journal: Cell Rep

PubMed ID: 34289364

Doi: 10.1016/j.celrep.2021.109392

Products & Services: Plasmid DNA Preparation

Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis

Authors: Kexin Zhu, Dong Yu, Jiahui An, Yufeng Li

Journal: Vet Res

PubMed ID: 34225787

Doi: 10.1186/s13567-021-00967-1

Products & Services: Plasmid DNA Preparation

Preerythrocytic Vaccine Antigens Enhance Sterile Protection in Mice Induced by Circumsporozoite Protein

Authors: Shaji Daniel, Alexander Pichugin, Holly Torano, Jonathan P Renn, Jennifer Kwan, Matthew V Cowles, Solomon Conteh, Lynn E Lambert, Nada Alani, Nicholas J MacDonald, Weili Dai, Kendrick Highsmith, Charles Anderson, J Patrick Gorres, Javonn Musgrove, Brandi Butler, Nouf Althubaiti, Saurabh Dixit, Stasya Zarling-Bejma, Urszula Krzych, Patrick E Duffy

Journal: Infect Immun

PubMed ID: 34310889

Doi: 10.1128/IAI.00165-21

Products & Services: Plasmid DNA Preparation

Host-emitted amino acid cues regulate bacterial chemokinesis to enhance colonization

Authors: Catherine D Robinson, Emily G Sweeney, Julia Ngo, Emily Ma, Arden Perkins, T Jarrod Smith, Nicolas L Fernandez, Christopher M Waters, S James Remington, Brendan J M Bohannan, Karen Guillemin

Journal: Cell Host Microbe

PubMed ID: 34233153

Doi: 10.1016/j.chom.2021.06.003

Products & Services: Plasmid DNA Preparation

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

Authors: Seth H Pincus, Ryan B Craig, Lauren Weachter, Celia C LaBranche, Rafiq Nabi, Connie Watt, Mark Raymond, Tami Peters, Kejing Song, Grace A Maresh, David C Montefiori, Pamela A Kozlowski

Journal: Vaccines (Basel)

PubMed ID: 34358190

Doi: 10.3390/vaccines9070774

Products & Services: Plasmid DNA Preparation

Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals

Authors: Tomohiro Suzuki, Mayuko Hayashi, Tetsuro Komatsu, Akiko Tanioka, Masahiro Nagasawa, Kyoko Tanimura-Inagaki, Mohammad Sharifur Rahman, Shinnosuke Masuda, Kosuke Yusa, Juro Sakai, Hiroshi Shibata, Takeshi Inagaki

Journal: Endocr J

PubMed ID: 34261826

Doi: 10.1507/endocrj.EJ21-0255

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A rechargeable anti-thrombotic coating for blood-contacting devices

Authors: Hyun Ok Ham, Carolyn A Haller, Guowei Su, Erbin Dai, Madhukar S Patel, David R Liu, Jian Liu, Elliot L Chaikof

Journal: Biomaterials

PubMed ID: 34303154

Doi: 10.1016/j.biomaterials.2021.121011

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Comparative genetic analyses provide clues about capsule switching in Streptococcus suis 2 strains with different virulence levels and genetic backgrounds

Authors: Yinchu Zhu, Wenyang Dong, Jiale Ma, Yue Zhang, Xiaojun Zhong, Zihao Pan, Guangjin Liu, Zongfu Wu, Huochun Yao

Journal: Microbiol Res

PubMed ID: 34256310

Doi: 10.1016/j.micres.2021.126814

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An Integrated Approach for Discovering Noncanonical MHC-I Peptides Encoded by Small Open Reading Frames

Authors: Lei Chen, Yuanliang Zhang, Ying Yang, Yang Yang, Huihui Li, Xuan Dong, Hongwei Wang, Zhi Xie, Qian Zhao

Journal: J Am Soc Mass Spectrom

PubMed ID: 34260243

Doi: 10.1021/jasms.1c00076

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Upregulation of fibroblast growth factor 2 contributes to endometriosis through SPRYs/DUSP6/ERK signaling pathway

Authors: Xiaoyan Yu, Yuping Wang, Xiaowei Tan, Mingjiang Li

Journal: Acta Histochem

PubMed ID: 34224989

Doi: 10.1016/j.acthis.2021.151749

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Genome analysis of cotton leafroll dwarf virus reveals variability in the silencing suppressor protein, genotypes and genomic recombinants in the USA

Authors: Afsha Tabassum, Sudeep Bag, Nelson D Suassuna, Kassie N Conner, Peng Chee, Robert C Kemerait, Phillip Roberts

Journal: PLoS ONE

PubMed ID: 34232966

Doi: 10.1371/journal.pone.0252523

Products & Services: PCR Cloning and Subcloning

Comparison of alternative integration sites in the chromosome and the native plasmids of the cyanobacterium Synechocystis sp PCC 6803 in respect to expression efficiency and copy number

Authors: Csaba Nagy, Kati Thiel, Edita Mulaku, Henna Mustila, Paula Tamagnini, Eva-Mari Aro, Catarina C Pacheco, Pauli Kallio

Journal: Microb Cell Fact

PubMed ID: 34246263

Doi: 10.1186/s12934-021-01622-2

Products & Services: PCR Cloning and Subcloning

Mouse Models of Achromatopsia in Addressing Temporal "Point of No Return" in Gene-Therapy

Authors: Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Sarah R Levi, Wan-Chun Huang, Chun-Wei Hsu, Hung-Hsi Wang, Nelson Chen, Yun-Ju Tseng, Peter M J Quinn, Ming-Hong Tai, Chyuan-Sheng Lin, Stephen H Tsang

Journal: Int J Mol Sci

PubMed ID: 34360834

Doi: 10.3390/ijms22158069

Products & Services: PCR Cloning and Subcloning

Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

Authors: Benoît Malleret, Abbas El Sahili, Matthew Zirui Tay, Guillaume Carissimo, Alice Soh Meoy Ong, Wisna Novera, Jianqing Lin, Rossarin Suwanarusk, Varakorn Kosaisavee, Trang T T Chu, Ameya Sinha, Shanshan Wu Howland, Yiping Fan, Jakub Gruszczyk, Wai-Hong Tham, Yves Colin, Sebastian Maurer-Stroh, Georges Snounou, Lisa F P Ng, Jerry Kok Yen Chan, Ann-Marie Chacko, Julien Lescar, Rajesh Chandramohanadas, François Nosten, Bruce Russell, Laurent Rénia

Journal: Nat Microbiol

PubMed ID: 34294905

Doi: 10.1038/s41564-021-00939-3

Products & Services: PCR Cloning and Subcloning

Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2

Authors: Masahiro Naganuma, Hisashi Tadakuma, Yukihide Tomari

Journal: Nat Commun

PubMed ID: 34257295

Doi: 10.1038/s41467-021-24555-1

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Absolute quantification of SARS-CoV-2 with Clarity Plus™ digital PCR

Authors: Shawn Yi Han Tan, Sheng Yi Milton Kwek, Huiyu Low, Yan Ling Joy Pang

Journal: Methods

PubMed ID: 34273478

Doi: 10.1016/j.ymeth.2021.07.005

Products & Services: ORF cDNA Clones/MolecularCloud

Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

Authors: Elita Yuliantie, Wijnand J C van der Velden, Viktorija Labroska, Antao Dai, Fenghui Zhao, Sanaz Darbalaei, Giuseppe Deganutti, Tongyang Xu, Qingtong Zhou, Dehua Yang, Mette M Rosenkilde, Patrick M Sexton, Ming-Wei Wang, Denise Wootten

Journal: Biochem Pharmacol

PubMed ID: 34339714

Doi: 10.1016/j.bcp.2021.114715

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Functional Analyses of Four Missense Mutations Present in Patients with Atypical Femoral Fractures

Authors: Nerea Ugartondo, Núria Martínez-Gil, Mònica Esteve, Natàlia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogués, Adolfo Díez-Pérez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells

Journal: Int J Mol Sci

PubMed ID: 34299011

Doi: 10.3390/ijms22147395

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Transmissible gastroenteritis virus ORF3b up-regulates miR-885-3p to counteract TNF-α production via inhibiting NF-κB pathway

Authors: Jianxiong Guo, Xiaomin Zhao, Zhihao Liu, Dan Liu, Xiaoyi Tang, Kaili Wang, Mengli Wang, Yong Huang, Dewen Tong

Journal: Vet Microbiol

PubMed ID: 34375914

Doi: 10.1016/j.vetmic.2021.109189

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The protective effect of NF-κB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis

Authors: Jun-Yan Jiang, Dai-Jiang Liu, Mao-Xia Liu

Journal: Scand J Gastroenterol

PubMed ID: 34310252

Doi: 10.1080/00365521.2021.1953130

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Phenotypic characterization of cell culture-derived hepatitis E virus subjected to different chemical treatments: Application in virus removal via nanofiltration

Authors: Shoji Ideno, Takamasa Inoue, Kadue Takahashi, Takeru Urayama, Hideki Maeno, Kaoru Takeuchi, Kaoru Sakai

Journal: J Virol Methods

PubMed ID: 34302862

Doi: 10.1016/j.jviromet.2021.114244

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Convergent epitope-specific T cell responses after SARS-CoV-2 infection and vaccination

Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, E Kaitlynn Allen, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Jeremy Chase Crawford, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas

Journal: medrxiv

PubMed ID: 34341799

Doi: 10.1101/2021.07.12.21260227

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Unconventional Spidroin Assemblies in Aqueous Dope for Spinning into Tough Synthetic Fibers

Authors: Chun-Fei Hu, Zhi-Gang Qian, Qingfa Peng, Yaopeng Zhang, Xiao-Xia Xia

Journal: ACS Biomater Sci Eng

PubMed ID: 34259496

Doi: 10.1021/acsbiomaterials.1c00492

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A -Derived Particulate Vaccine Protects against Infection

Authors: Zennia Jean C Gonzaga, Christina Merakou, Antonio DiGiandomenico, Gregory P Priebe, Bernd H A Rehm

Journal: Vaccines (Basel)

PubMed ID: 34358220

Doi: 10.3390/vaccines9070803

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Molecular Survey of Tick-Borne Pathogens Reveals Diversity and Novel Organisms With Veterinary and Public Health Significance in Wildlife From a National Nature Reserve of China

Authors: Jifei Yang, Xiaojun Wang, Jinming Wang, Zhijie Liu, Qingli Niu, Muhammad Uzair Mukhtar, Guiquan Guan, Hong Yin

Journal: Front Vet Sci

PubMed ID: 34322535

Doi: 10.3389/fvets.2021.682963

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Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Authors: Mark Ultsch, Michael J Holliday, Stefan Gerhardy, Paul Moran, Suzie J Scales, Nidhi Gupta, Francesca Oltrabella, Cecilia Chiu, Wayne Fairbrother, Charles Eigenbrot, Daniel Kirchhofer

Journal: Commun Biol

PubMed ID: 34316015

Doi: 10.1038/s42003-021-02387-5

Products & Services: DNA Sequencing

T cruzi DNA polymerase beta (Tcpolβ) is phosphorylated in vitro by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity

Authors: Edio Maldonado, Diego A Rojas, Fabiola Urbina, Aldo Solari

Journal: PLoS Negl Trop Dis

PubMed ID: 34260580

Doi: 10.1371/journal.pntd.0009588

Products & Services: DNA Sequencing

RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non-small cell lung cancer cells to anlotinib by regulating CX3CR1-fractalkine expression

Authors: Min Wu, Mengmeng Jin, Xiaohui Cao, Kun Qian, Lei Zhao

Journal: Drug Dev Res

PubMed ID: 34319598

Doi: 10.1002/ddr.21861

Products & Services: DNA Sequencing

Exosome-delivered miR-221/222 exacerbates tumor liver metastasis by targeting SPINT1 in colorectal cancer

Authors: Fei Tian, Peiyun Wang, Dan Lin, Jiajia Dai, Qibing Liu, Yu Guan, Yang Zhan, Yichen Yang, Wenpeng Wang, Jiefu Wang, Jia Liu, Lei Zheng, Yan Zhuang, Jun Hu, Junfeng Wang, Dalu Kong, Kegan Zhu

Journal: Cancer Sci

PubMed ID: 34125460

Doi: 10.1111/cas.15028

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SPNS2 enables T cell egress from lymph nodes during an immune response

Authors: Martyna Okuniewska, Victoria Fang, Audrey Baeyens, Varsha Raghavan, June-Yong Lee, Dan R Littman, Susan R Schwab

Journal: Cell Rep

PubMed ID: 34260944

Doi: 10.1016/j.celrep.2021.109368

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ZIC2 upregulates lncRNA SNHG12 expression to promote endometrial cancer cell proliferation and migration by activating the Notch signaling pathway

Authors: Pengyu Cai, Gaijuan Li, Mingxiu Wu, Bin Zhang, Hong Bai

Journal: Mol Med Rep

PubMed ID: 34278490

Doi: 10.3892/mmr.2021.12271

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De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity

Authors: Laura Marín, Ignacio Gutiérrez-Del-Río, Claudio Jesús Villar, Felipe Lombó

Journal: Microb Biotechnol

PubMed ID: 34216097

Doi: 10.1111/1751-7915.13874

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Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein

Authors: Eric H-L Chen, Kuei-Ming Lin, Jason C Sang, Meng-Ru Ho, Chih-Hsuan Lee, Orion Shih, Chun-Jen Su, Yi-Qi Yeh, U-Ser Jeng, Rita P-Y Chen

Journal: IUBMB Life

PubMed ID: 34288372

Doi: 10.1002/iub.2528

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Evolution of a σ-(c-di-GMP)-anti-σ switch

Authors: Maria A Schumacher, Kelley A Gallagher, Neil A Holmes, Govind Chandra, Max Henderson, David T Kysela, Richard G Brennan, Mark J Buttner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34290147

Doi: 10.1073/pnas.2105447118

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The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3

Authors: Lorenzo Soini, Seppe Leysen, Tom Crabbe, Jeremy Davis, Christian Ottmann

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 34341191

Doi: 10.1107/S2053230X21006658

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Selective Moonlighting Cell-Penetrating Peptides

Authors: Rafael Morán-Torres, David A Castillo González, Maria Luisa Durán-Pastén, Beatriz Aguilar-Maldonado, Susana Castro-Obregón, Gabriel Del Rio

Journal: Pharmaceutics

PubMed ID: 34452080

Doi: 10.3390/pharmaceutics13081119

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A GRA2 minimal promoter improves the efficiency of TATi / Tet-Off conditional regulation of gene expression in Toxoplasma gondii

Authors: Mohammad Farouq Sharifpour, Shadi Khadiv, Markus Meissner, Milton M McAllister

Journal: Mol Biochem Parasitol.

PubMed ID: 34051228

Doi: 10.1016/j.molbiopara.2021.111384

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Bisulfite Amplicon Sequencing Can Detect Glia and Neuron Cell-Free DNA in Blood Plasma

Authors: Zac Chatterton, Natalia Mendelev, Sean Chen, Walter Carr, Gary H Kamimori, Yongchao Ge, Andrew J Dwork, Fatemeh Haghighi

Journal: Front Mol Neurosci

PubMed ID: 34276305

Doi: 10.3389/fnmol.2021.672614

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A single residue can modulate nanocage assembly in salt dependent ferritin

Authors: Mantu Kumar, Joanna Markiewicz-Mizera, Julian David Janna Olmos, Piotr Wilk, Przemysław Grudnik, Artur P Biela, Małgorzata Jemioła-Rzemińska, Andrzej Górecki, Soumyananda Chakraborti, Jonathan G Heddle

Journal: Nanoscale

PubMed ID: 34195748

Doi: 10.1039/d1nr01632f

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Human low-density lipoprotein receptor plays an important role in hepatitis B virus infection

Authors: Yingying Li, Guangxiang Luo

Journal: PLoS Pathog

PubMed ID: 34293069

Doi: 10.1371/journal.ppat.1009722

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Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex

Authors: Maria Velkova, Nicola Silva, Maria Rosaria Dello Stritto, Alexander Schleiffer, Pierre Barraud, Markus Hartl, Verena Jantsch

Journal: PLoS Genet

PubMed ID: 34252074

Doi: 10.1371/journal.pgen.1009663

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Molecular and biological characterization of severe strain infecting soybean in India

Authors: Nagamani Sandra, Ankita Tripathi, S K Lal, Bikash Mandal, Rakesh Kumar Jain

Journal: 3 Biotech

PubMed ID: 34458057

Doi: 10.1007/s13205-021-02925-2

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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

Authors: James M Murithi, Ioanna Deni, Charisse Flerida A Pasaje, John Okombo, Jessica L Bridgford, Nina F Gnädig, Rachel L Edwards, Tomas Yeo, Sachel Mok, Anna Y Burkhard, Olivia Coburn-Flynn, Eva S Istvan, Tomoyo Sakata-Kato, Maria G Gomez-Lorenzo, Annie N Cowell, Kathryn J Wicht, Claire Le Manach, Gavreel F Kalantarov, Sumanta Dey, Maëlle Duffey, Benoît Laleu, Amanda K Lukens, Sabine Ottilie, Manu Vanaerschot, Ilya N Trakht, Francisco-Javier Gamo, Dyann F Wirth, Daniel E Goldberg, Audrey R Odom John, Kelly Chibale, Elizabeth A Winzeler, Jacquin C Niles, David A Fidock

Journal: Cell Chem Biol

PubMed ID: 34233174

Doi: 10.1016/j.chembiol.2021.06.006

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YB-1 Is Altered in Pregnancy-Associated Disorders and Affects Trophoblast in Vitro Properties via Alternation of Multiple Molecular Traits

Authors: Violeta Stojanovska, Aneri Shah, Katja Woidacki, Florence Fischer, Mario Bauer, Jonathan A Lindquist, Peter R Mertens, Ana C Zenclussen

Journal: Int J Mol Sci

PubMed ID: 34281280

Doi: 10.3390/ijms22137226

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Genome-Wide Identification and Expression Analysis of Tomato Gene Family during Development and Stress

Authors: Lu Yang, Haohao Cao, Xiaoping Zhang, Liangxian Gui, Qiang Chen, Gui Qian, Jiaxin Xiao, Zhengguo Li

Journal: Int J Mol Sci

PubMed ID: 34299327

Doi: 10.3390/ijms22147708

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Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Authors: Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song

Journal: Theranostics

PubMed ID: 34373735

Doi: 10.7150/thno.56737

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Genomic identification of nitrogen assimilation-related genes and transcriptional characterization of their responses to nitrogen in allotetraploid rapeseed

Authors: Yue Wang, Ying-Peng Hua, Ting Zhou, Jin-Yong Huang, Cai-Peng Yue

Journal: Mol Biol Rep

PubMed ID: 34327662

Doi: 10.1007/s11033-021-06599-0

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Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Authors: Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dan-Dan Shen, Yan Zhang, Tian Xia, Raymond C Stevens, H Eric Xu, Dehua Yang, Lihua Zhao, Ming-Wei Wang

Journal: Elife

PubMed ID: 34254582

Doi: 10.7554/eLife.68719

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Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

Authors: Maryam Izadi, Eric Seemann, Dirk Schlobinski, Lukas Schwintzer, Britta Qualmann, Michael M Kessels

Journal: Elife

PubMed ID: 34264190

Doi: 10.7554/eLife.67718

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HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer

Authors: Miranda E Clements, Lauren Holtslander, Courtney Edwards, Vera Todd, Samuel D R Dooyema, Kennady Bullock, Kensey Bergdorf, Cynthia A Zahnow, Roisin M Connolly, Rachelle W Johnson

Journal: Oncogene

PubMed ID: 34247191

Doi: 10.1038/s41388-021-01931-1

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Low efficiency of leucocyte plugging-based drug delivery to cancer in mice

Authors: Baifeng Qian, Andreas Termer, Christof M Sommer, Arianeb Mehrabi, Eduard Ryschich

Journal: Drug Deliv Transl Res

PubMed ID: 34319578

Doi: 10.1007/s13346-021-01028-y

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Overexpression of Douglas-Fir () in Induces Embryonic Programs and Embryo-like Structures in the Mutant but Not in Wild Type Plants

Authors: Mariana A Vetrici, Dmytro P Yevtushenko, Santosh Misra

Journal: Plants (Basel)

PubMed ID: 34451571

Doi: 10.3390/plants10081526

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Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

Authors: Naotaka Tsutsumi, Qianhui Qu, Maša Mavri, Maibritt S Baggesen, Shoji Maeda, Deepa Waghray, Christian Berg, Brian K Kobilka, Mette M Rosenkilde, Georgios Skiniotis, K Christopher Garcia

Journal: Immunity

PubMed ID: 34216564

Doi: 10.1016/j.immuni.2021.06.001

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Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

Authors: Johannes Gebert, Ozkan Gelincik, Mine Oezcan-Wahlbrink, Jason D Marshall, Alejandro Hernandez-Sanchez, Katharina Urban, Mark Long, Eduardo Cortes, Elena Tosti, Eva-Maria Katzenmaier, Yurong Song, Ali Elsaadi, Nan Deng, Eduardo Vilar, Vera Fuchs, Nina Nelius, Yan P Yuan, Aysel Ahadova, Shizuko Sei, Robert H Shoemaker, Asad Umar, Lei Wei, Song Liu, Peer Bork, Winfried Edelmann, Magnus von Knebel Doeberitz, Steven M Lipkin, Matthias Kloor

Journal: Gastroenterology

PubMed ID: 34224739

Doi: 10.1053/j.gastro.2021.06.073

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Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus

Authors: Elvira Tarasova, Sonali Dhindwal, Matthew Popp, Sakeenah Hussain, Reza Khayat

Journal: MBio

PubMed ID: 34311576

Doi: 10.1128/mBio.00763-21

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Fulvic acid enhances drought resistance in tea plants by regulating the starch and sucrose metabolism and certain secondary metabolism

Authors: Chen Qiu, Jianhao Sun, Jiazhi Shen, Shuning Zhang, Yiqian Ding, Zhongshuai Gai, Kai Fan, Lubin Song, Bo Chen, Zhaotang Ding, Yu Wang

Journal: J Proteomics

PubMed ID: 34298183

Doi: 10.1016/j.jprot.2021.104337

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Antibodies Targeting Two Epitopes in SARS-CoV-2 Neutralize Pseudoviruses with the Spike Proteins from Different Variants

Authors: Chee-Hing Yang, Hui-Chun Li, Wen-Han Lee, Shih-Yen Lo

Journal: Pathogens

PubMed ID: 34358019

Doi: 10.3390/pathogens10070869

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TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans

Authors: Yisui Xia, Ryo Fujisawa, Tom D Deegan, Remi Sonneville, Karim P M Labib

Journal: EMBO J

PubMed ID: 34269473

Doi: 10.15252/embj.2021108053

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Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation

Authors: Joel D Allen, Himanshi Chawla, Firdaus Samsudin, Lorena Zuzic, Aishwary Tukaram Shivgan, Yasunori Watanabe, Wan-Ting He, Sean Callaghan, Ge Song, Peter Yong, Philip J M Brouwer, Yutong Song, Yongfei Cai, Helen M E Duyvesteyn, Tomas Malinauskas, Joeri Kint, Paco Pino, Maria J Wurm, Martin Frank, Bing Chen, David I Stuart, Rogier W Sanders, Raiees Andrabi, Dennis R Burton, Sai Li, Peter J Bond, Max Crispin

Journal: Biochemistry

PubMed ID: 34213308

Doi: 10.1021/acs.biochem.1c00279

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Seasonal Variation in Transcriptomic Profiling of Fully Developed Tuberous Roots Enriches Candidate Genes in Essential Metabolic Pathways and Phytohormone Signaling

Authors: Qianqian Xiang, Siyuan Hu, Ayalew Ligaba-Osena, Jiayao Yang, Fudan Tong, Wanli Guo

Journal: Front Plant Sci

PubMed ID: 34305963

Doi: 10.3389/fpls.2021.659645

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Genome-Wide Characterization of B-Box Gene Family and Its Roles in Responses to Light Quality and Cold Stress in Tomato

Authors: Xin Bu, Xiujie Wang, Jiarong Yan, Ying Zhang, Shunyuan Zhou, Xin Sun, Youxin Yang, Golam Jalal Ahammed, Yufeng Liu, Mingfang Qi, Feng Wang, Tianlai Li

Journal: Front Plant Sci

PubMed ID: 34290726

Doi: 10.3389/fpls.2021.698525

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Emerging Insights into Keratin 16 Expression during Metastatic Progression of Breast Cancer

Authors: Maha Elazezy, Sandra Schwentesius, Luisa Stegat, Harriet Wikman, Stefan Werner, Wael Y Mansour, Antonio Virgilio Failla, Sven Peine, Volkmar Müller, Jean Paul Thiery, Majid Ebrahimi Warkiani, Klaus Pantel, Simon A Joosse

Journal: Cancers (Basel)

PubMed ID: 34359774

Doi: 10.3390/cancers13153869

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A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors

Authors: Subramanyam Vankadara, Yun Xuan Wong, Boping Liu, Yi Yang See, Li Hong Tan, Qian Wen Tan, Gang Wang, Ratna Karuna, Xue Guo, Shu Ting Tan, Jia Yi Fong, Joma Joy, C S Brian Chia

Journal: Bioorg Med Chem Lett

PubMed ID: 34271072

Doi: 10.1016/j.bmcl.2021.128263

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Coatomer protein COPƐ, a novel NS1-interacting protein, promotes the replication of Porcine Parvovirus via attenuation of the production of type I interferon

Authors: Songbiao Chen, Nannan Chen, Bichen Miao, Jiang Peng, Xuezhi Zhang, Caiyi Chen, Xiujuan Zhang, Lingling Chang, Qian Du, Yong Huang, Dewen Tong

Journal: Vet Microbiol

PubMed ID: 34365051

Doi: 10.1016/j.vetmic.2021.109188

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Overlapping Functions of the Paralogous Proteins AtPAP2 and AtPAP9 in

Authors: Renshan Zhang, Xiaoqian Guan, Meijing Yang, Yee-Song Law, Chia Pao Voon, Junran Yan, Feng Sun, Boon Leong Lim

Journal: Int J Mol Sci

PubMed ID: 34298863

Doi: 10.3390/ijms22147243

SARS-CoV-2 Infection in Dogs and Cats from Southern Germany and Northern Italy during the First Wave of the COVID-19 Pandemic

Authors: Julia Klaus, Eric Zini, Katrin Hartmann, Herman Egberink, Anja Kipar, Michèle Bergmann, Carlo Palizzotto, Shan Zhao, Francesco Rossi, Vittoria Franco, Federico Porporato, Regina Hofmann-Lehmann, Marina L Meli

Journal: Viruses

PubMed ID: 34452319

Doi: 10.3390/v13081453

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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

Authors: Mark P Labrecque, Lisha G Brown, Ilsa M Coleman, Bryce Lakely, Nicholas J Brady, John K Lee, Holly M Nguyen, Dapei Li, Brian Hanratty, Michael C Haffner, David S Rickman, Lawrence D True, Daniel W Lin, Hung-Ming Lam, Joshi J Alumkal, Eva Corey, Peter S Nelson, Colm Morrissey

Journal: Cancer Res

PubMed ID: 34312180

Doi: 10.1158/0008-5472.CAN-21-0307

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Membranotropic and biological activities of the membrane fusion peptides from SARS-CoV spike glycoprotein: The importance of the complete internal fusion peptide domain

Authors: Luis Guilherme Mansor Basso, Ana Eliza Zeraik, Ana Paula Felizatti, Antonio José Costa-Filho

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34274319

Doi: 10.1016/j.bbamem.2021.183697

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CDK1 controls CHMP7-dependent nuclear envelope reformation

Authors: Alberto T Gatta, Yolanda Olmos, Caroline L Stoten, Qu Chen, Peter B Rosenthal, Jeremy G Carlton

Journal: Elife

PubMed ID: 34286694

Doi: 10.7554/eLife.59999

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Endomembrane-Targeting Effectors Modulate PAMP Triggered Immune Responses in Plants

Authors: Md Musharaf Hossain, Edel Pérez-López, Christopher D Todd, Yangdou Wei, Peta C Bonham-Smith

Journal: Front Microbiol

PubMed ID: 34276588

Doi: 10.3389/fmicb.2021.651279

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ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation

Authors: Xuerui Zhang, Zhaoqing Hu, Xinran Wang, Lin Li, Banghui Zhu, Xiaolei Lin, Jing Zhang, Zichun Hua

Journal: Cancer Lett

PubMed ID: 34324862

Doi: 10.1016/j.canlet.2021.07.033

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Neofunctionalisation of the Sli gene leads to self-compatibility and facilitates precision breeding in potato

Authors: Ernst-Jan Eggers, Ate van der Burgt, Sjaak A W van Heusden, Michiel E de Vries, Richard G F Visser, Christian W B Bachem, Pim Lindhout

Journal: Nat Commun

PubMed ID: 34230471

Doi: 10.1038/s41467-021-24267-6

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Targeting TRAF3IP2 alleviates high glucose-induced cardiomyocyte inflammation and apoptosis

Authors: Jing Wei, Tao Yan, Yuanhong Liang

Journal: Drug Dev Res

PubMed ID: 34260107

Doi: 10.1002/ddr.21856

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Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface

Authors: Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Štefulj

Journal: Int J Mol Sci

PubMed ID: 34360573

Doi: 10.3390/ijms22157807

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Nanopore Sequencing Accurately Identifies the Cisplatin Adduct on DNA

Authors: Fubo Ma, Shuanghong Yan, Jinyue Zhang, Yu Wang, Liying Wang, Yuqin Wang, Shanyu Zhang, Xiaoyu Du, Panke Zhang, Hong-Yuan Chen, and Shuo Huang

Journal: ACS Sensors

PubMed ID: 34319692

Doi: doi.org/10.1021/acssensors.1c01212

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Mapping Potential Engineering Sites of Mycobacterium smegmatis porin A (MspA) to Form a Nanoreactor

Authors: Jinyue Zhang, Jiao Cao, Wendong Jia, Shanyu Zhang, Shuanghong Yan, Yuqin Wang, Panke Zhang, Hong-Yuan Chen, Wenfei Li, Shuo Huang

Journal: ACS Sens.

PubMed ID: 34107684

Doi: 10.1021/acssensors.1c00792

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