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Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies

Authors: Yan Lou, Wenxiang Zhao, Haitao Wei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, Ping Wang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du, Tingbo Liang, Yunqing Qiu, Mingyao Liu

Journal: Biotechnol J

PubMed ID: 34379353

Doi: 10.1002/biot.202100207

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Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10

Authors: Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan

Journal: J Biol Chem

PubMed ID: 34478713

Doi: 10.1016/j.jbc.2021.101141

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The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy

Authors: Shayne E Quinn, Lu Huang, Jason G Kerkvliet, Joel A Swanson, Steve Smith, Adam D Hoppe, Robert B Anderson, Natalie W Thiex, Brandon L Scott

Journal: Nat Commun

PubMed ID: 34376698

Doi: 10.1038/s41467-021-25187-1

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Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production

Authors: Sujata Senapati, Ross J Darling, Kathleen A Ross, Michael J Wannemeuhler, Balaji Narasimhan, Surya K Mallapragada

Journal: Sci Adv

PubMed ID: 34348905

Doi: 10.1126/sciadv.abj1691

Products & Services: Proteins, Expression, Isolation and Analysis

Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy

Authors: Jessica S Fortin, Ashley A Hetak, Kelsey E Duggan, Caroline M Burglass, Hailey B Penticoff, Harold C Schott

Journal: Sci Rep

PubMed ID: 34362943

Doi: 10.1038/s41598-021-95396-7

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A chimeric virus-based probe unambiguously detects live circulating tumor cells with high specificity and sensitivity

Authors: Xinping Fu, Lihua Tao, Xiaoliu Zhang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34631928

Doi: 10.1016/j.omtm.2021.08.007

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Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Authors: Vasiliki Courelli, Alla Ahmad, Majid Ghassemian, Chris Pruitt, Paul J Mills, Geert W Schmid-Schönbein

Journal: Cell Mol Bioeng

PubMed ID: 34900012

Doi: 10.1007/s12195-021-00693-w

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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease

Authors: Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L Bunting, Sarah G Aldous, Antonio Porro, José R Vicente, Nicholas D Allen, Hilary Wilkinson, Gillian P Bates, Alessandro A Sartori, Konstantinos Thalassinos, Gabriel Balmus, Sarah J Tabrizi

Journal: Cell Rep

PubMed ID: 34469738

Doi: 10.1016/j.celrep.2021.109649

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Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L

Authors: Mona Raeispour Shirazi, Sara Alsadat Rahpeyma, Sajad Rashidi Monfared, Jafar Zolala, Azadeh Lohrasbi-Nejad

Journal: PLoS ONE

PubMed ID: 34449796

Doi: 10.1371/journal.pone.0256704

Products & Services: Protein Tools

Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19

Authors: Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, Berenice Calderón-Pérez, Miriam Pérez-Saldívar, Karla Acosta-Virgen, Hugo González-Conchillos, Brenda Vargas-Hernández, Ana Olivares-Martínez, Roberto Ruiz-Medrano, Daniela Roa-Velázquez, Edgar Morales-Ríos, Jorge Ramos-Flores, Gustavo Torres-Franco, Diana Peláez-González, Jorge Fernández-Hernández, Martha Espinosa-Cantellano, Diana Tapia-Sidas, José Abrahan Ramírez-Pool, América Padilla-Viveros, Beatriz Xoconostle-Cázares

Journal: Vaccines (Basel)

PubMed ID: 34452053

Doi: 10.3390/vaccines9080928

Products & Services: Recombinant Proteins

Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

Authors: Suhas Sureshchandra, Michael Z Zulu, Brianna Doratt, Allen Jankeel, Delia Tifrea, Robert Edwards, Monica Rincon, Nicole E Marshall, Ilhem Messaoudi

Journal: biorxiv

PubMed ID: 34462741

Doi: 10.1101/2021.08.23.457408

Products & Services: Proteins, Expression, Isolation and Analysis

Multiple epitopes of hepatitis B virus surface antigen targeted by human plasma-derived immunoglobulins coincide with clinically observed escape mutations

Authors: Sreya Tarafdar, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Lu Deng, Yanqun Xu, Yong He, Evi Struble, Pei Zhang

Journal: J Med Virol

PubMed ID: 34406663

Doi: 10.1002/jmv.27278

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Simultaneous Multiplex Genome Engineering Accelerated Natural Transformation in

Authors: Aihua Deng, Zhaopeng Sun, Tiantian Wang, Di Cui, Lai Li, Shuwen Liu, Fei Huang, Tingyi Wen

Journal: Front Microbiol

PubMed ID: 34484154

Doi: 10.3389/fmicb.2021.714449

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Comparative phylogenetic analysis of CBL reveals the gene family evolution and functional divergence in Saccharum spontaneum

Authors: Xiaomin Feng, Yongjun Wang, Nannan Zhang, Shuai Gao, Jiayun Wu, Rui Liu, Yonghong Huang, Jisen Zhang, Yongwen Qi

Journal: BMC Plant Biol

PubMed ID: 34425748

Doi: 10.1186/s12870-021-03175-3

Products & Services: Protein Tools

Characterization of murine cytomegalovirus infection and induction of calcification in Murine Aortic Vascular Smooth Muscle Cells (MOVAS)

Authors: Cassandra M Bonavita, Timothy M White, Brent A Stanfield, Rhonda D Cardin

Journal: J Virol Methods

PubMed ID: 34461152

Doi: 10.1016/j.jviromet.2021.114270

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Nontypeable P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance

Authors: Oskar Thofte, Serena Bettoni, Yu-Ching Su, John Thegerström, Sandra Jonsson, Emma Mattsson, Linda Sandblad, Sara Martí, Junkal Garmendia, Anna M Blom, Kristian Riesbeck

Journal: J Immunol

PubMed ID: 34433620

Doi: 10.4049/jimmunol.2100105

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An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

Authors: Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen, Xianlei Li, Qiankun Ni, Yuan Yuan, Yaling Gan, Junge Chen, Fangzhou Li, Jinchao Zhang, Caiwen Ou, Yongxiang Zhao, Xiaoxuan Liu, Xing-Jie Liang

Journal: Nat Commun

PubMed ID: 34400628

Doi: 10.1038/s41467-021-25197-z

Products & Services: Recombinant Antibody Expression

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression

Authors: Ling Zhang, Lei Zhang, Rubo Sui

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34421302

Doi: 10.2147/NDT.S317207

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Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice

Authors: Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W Ian Lipkin, David M Knipe, Eurico Arruda, Sean P J Whelan

Journal: MBio

PubMed ID: 34340542

Doi: 10.1128/mBio.00463-21

Products & Services: Mammalian Expression

The Role of Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast

Authors: Piotr Hapeta, Patrycja Szczepańska, Tadeusz Witkowski, Jean-Marc Nicaud, Anne-Marie Crutz-Le Coq, Zbigniew Lazar

Journal: Int J Mol Sci

PubMed ID: 34502217

Doi: 10.3390/ijms22179282

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Secondary Structure of Human Evolved Gene Product NCYM Analyzed by Vacuum-Ultraviolet Circular Dichroism

Authors: Tatsuhito Matsuo, Kazuma Nakatani, Taiki Setoguchi, Koichi Matsuo, Taro Tamada, Yusuke Suenaga

Journal: Front Oncol

PubMed ID: 34497756

Doi: 10.3389/fonc.2021.688852

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Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers

Authors: Khuraijam Dhanachandra Singh, Zaira P Jara, Terri Harford, Prasenjit Prasad Saha, Triveni R Pardhi, Russell Desnoyer, Sadashiva S Karnik

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34380734

Doi: 10.1073/pnas.2019126118

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Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

Authors: Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D Tolbert, Michael W Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes

Journal: biorxiv

PubMed ID: 34373853

Doi: 10.1101/2021.08.02.454546

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

Authors: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

Journal: Elife

PubMed ID: 34435951

Doi: 10.7554/eLife.68843

Products & Services: Recombinant Proteins

CRISPR-Cas9-mediated reactivation of the uricase pseudogene in human cells prevents acute hyperuricemia

Authors: Lais de Lima Balico, Eric A Gaucher

Journal: Mol Ther Nucleic Acids

PubMed ID: 34589279

Doi: 10.1016/j.omtn.2021.08.002

Products & Services: Mammalian Expression

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

Authors: Megan C Mladinich, Jonas N Conde, William R Schutt, Sook-Young Sohn, Erich R Mackow

Journal: MBio

PubMed ID: 34399621

Doi: 10.1128/mBio.01962-21

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

Authors: Dimitris C Kanellis, Jaime A Espinoza, Asimina Zisi, Elpidoforos Sakkas, Jirina Bartkova, Anna-Maria Katsori, Johan Boström, Lars Dyrskjøt, Helle Broholm, Mikael Altun, Simon J Elsässer, Mikael S Lindström, Jiri Bartek

Journal: Sci Adv

PubMed ID: 34348895

Doi: 10.1126/sciadv.abf7561

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Complete and efficient conversion of plant cell wall hemicellulose into high-value bioproducts by engineered yeast

Authors: Liang Sun, Jae Won Lee, Sangdo Yook, Stephan Lane, Ziqiao Sun, Soo Rin Kim, Yong-Su Jin

Journal: Nat Commun

PubMed ID: 34404791

Doi: 10.1038/s41467-021-25241-y

Products & Services: PCR Cloning and Subcloning

The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

Authors: Huafeng Lin, Gang Li, Xiangwen Peng, Aimin Deng, Lei Ye, Lei Shi, Tuanmei Wang, Jun He

Journal: Front Cell Infect Microbiol

PubMed ID: 34513721

Doi: 10.3389/fcimb.2021.590989

A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S

Authors: Xiankun Wang, Yuchun Zhao , Yaojie Gao , Xiangkun Luo , Aiqin Du , Zixin Deng , T. Mark Zabriskied , Xinyi Hea, and Ming Jiang

Journal: PNAS

PubMed ID: 34282016

Doi: 10.1073/pnas.2102318118

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Chemerin/ChemR23 signaling mediates the effects of ultra-high molecular weight polyethylene wear particles on the balance between osteoblast and osteoclast differentiation

Authors: Fengchao Zhao, Dingwei Cang, Jianzhi Zhang, Li Zheng

Journal: Ann Transl Med

PubMed ID: 34430590

Doi: 10.21037/atm-21-2945

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Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations

Authors: Konlavat Siriwattananon, Suwimon Manopwisedjaroen, Balamurugan Shanmugaraj, Eakachai Prompetchara, Chutitorn Ketloy, Supranee Buranapraditkun, Kittipan Tharakhet, Papatsara Kaewpang, Kiat Ruxrungtham, Arunee Thitithanyanont, Waranyoo Phoolcharoen

Journal: Vaccines (Basel)

PubMed ID: 34358160

Doi: 10.3390/vaccines9070744

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Lipopolysaccharide Binding Protein and CD14, Cofactors of Toll-like Receptors, Are Essential for Low-Grade Inflammation-Induced Exacerbation of Cartilage Damage in Mouse Models of Posttraumatic Osteoarthritis

Authors: Yoonkyung Won, Jeong-In Yang, Seulki Park, Jang-Soo Chun

Journal: Arthritis Rheumatol

PubMed ID: 33559324

Doi: 10.1002/art.41679

Products & Services: Recombinant Proteins

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

Authors: Mengyao Mu, Hongjing Zhao, Yu Wang, Menghao Guo, Xiaopan Nie, Yachen Liu, Mingwei Xing

Journal: Dev Comp Immunol

PubMed ID: 34329648

Doi: 10.1016/j.dci.2021.104211

Products & Services: Recombinant Antibody Expression

RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors

Authors: Megumi Shigematsu, Takuya Kawamura, Keisuke Morichika, Natsuko Izumi, Takashi Kiuchi, Shozo Honda, Venetia Pliatsika, Ryuma Matsubara, Isidore Rigoutsos, Susumu Katsuma, Yukihide Tomari, Yohei Kirino

Journal: Nat Commun

PubMed ID: 34301931

Doi: 10.1038/s41467-021-24681-w

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Cryo-EM structure of human Wntless in complex with Wnt3a

Authors: Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma

Journal: Nat Commun

PubMed ID: 34315898

Doi: 10.1038/s41467-021-24731-3

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Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Authors: Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang

Journal: Nat Commun

PubMed ID: 34244522

Doi: 10.1038/s41467-021-24514-w

Products & Services: Proteins, Expression, Isolation and Analysis

Contributions of S- and R-citalopram to the citalopram-induced modulation of the function of Nav15 voltage-gated sodium channels

Authors: Yoshihiko Nakatani, Taku Amano

Journal: Eur J Pharmacol

PubMed ID: 34280395

Doi: 10.1016/j.ejphar.2021.174316

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Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7-Expressing Carcinoma in the Cervicovaginal Tract

Authors: Talia R Henkle, Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Louise Ferrall, Deyin Xing, Chien-Fu Hung, T-C Wu

Journal: Cancer Res

PubMed ID: 34215618

Doi: 10.1158/0008-5472.CAN-21-0399

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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

Authors: Ahmad Jomaa, Simon Eitzinger, Zikun Zhu, Sowmya Chandrasekar, Kan Kobayashi, Shu-Ou Shan, Nenad Ban

Journal: Cell Rep

PubMed ID: 34260909

Doi: 10.1016/j.celrep.2021.109350

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A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

Authors: Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Journal: J Mol Biol

PubMed ID: 34302818

Doi: 10.1016/j.jmb.2021.167174

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The expansion of activated naive DNA autoreactive B cells and its association with disease activity in systemic lupus erythematosus patients

Authors: Kittikorn Wangriatisak, Chokchai Thanadetsuntorn, Thamonwan Krittayapoositpot, Chaniya Leepiyasakulchai, Thanitta Suangtamai, Pintip Ngamjanyaporn, Ladawan Khowawisetsut, Prasong Khaenam, Chavachol Setthaudom, Prapaporn Pisitkun, Patchanee Chootong

Journal: Arthritis Res Ther

PubMed ID: 34229724

Doi: 10.1186/s13075-021-02557-0

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Authors: Monique S Straub, Carolina Alvadia, Marta Sawicka, Raimund Dutzler

Journal: Elife

PubMed ID: 34263724

Doi: 10.7554/eLife.69800

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Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling

Authors: Hannes Merten, Fabian Brandl, Martina Zimmermann, Jonas V Schaefer, Linda Irpinio, Kine M K Sand, Jeannette Nilsen, Jan Terje Andersen, Uwe Zangemeister-Wittke, Andreas Plückthun

Journal: Eur J Pharm Biopharm

PubMed ID: 34303832

Doi: 10.1016/j.ejpb.2021.07.011

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

Authors: Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D Kwong

Journal: Nat Commun

PubMed ID: 34244481

Doi: 10.1038/s41467-021-24291-6

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MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin

Authors: Ji-Young Yoo, Margaret Yeh, Yin-Ying Wang, Christina Oh, Zhong-Ming Zhao, Balveen Kaur, Tae-Jin Lee

Journal: Biomedicines

PubMed ID: 34356844

Doi: 10.3390/biomedicines9070780

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Decline in neutralising antibody responses, but sustained T-cell immunity, in COVID-19 patients at 7 months post-infection

Authors: Jun Chen, Xiaomin Liu, Xinyu Zhang, Yixiao Lin, Danping Liu, Jingna Xun, Zhenyan Wang, Ling Gu, Qian Li, Dan Yin, Junyang Yang, Hongzhou Lu

Journal: Clin Transl Immunology

PubMed ID: 34336207

Doi: 10.1002/cti2.1319

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Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

Authors: Lisa R Volpatti, Rachel P Wallace, Shijie Cao, Michal M Raczy, Ruyi Wang, Laura T Gray, Aaron T Alpar, Priscilla S Briquez, Nikolaos Mitrousis, Tiffany M Marchell, Maria Stella Sasso, Mindy Nguyen, Aslan Mansurov, Erica Budina, Ani Solanki, Elyse A Watkins, Mathew R Schnorenberg, Andrew C Tremain, Joseph W Reda, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Shann S Yu, Balaji Manicassamy, James L LaBelle, Matthew V Tirrell, Glenn Randall, Marcin Kwissa, Melody A Swartz, Jeffrey A Hubbell

Journal: ACS Cent Sci

PubMed ID: 34466656

Doi: 10.1021/acscentsci.1c00596

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Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients

Authors: René Schramm, Angelika Costard-Jäckle, Rasmus Rivinius, Bastian Fischer, Benjamin Müller, Udo Boeken, Assad Haneya, Zdenek Provaznik, Cornelius Knabbe, Jan Gummert

Journal: Clin Res Cardiol

PubMed ID: 34241676

Doi: 10.1007/s00392-021-01880-5

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A highly efficient identification of mutants generated by CRISPR/Cas9 using the non‑functional DsRed assisted selection in Aspergillus oryzae

Authors: Yuzhen Li, Huanxin Zhang, Junxia Fan, Ziming Chen, Tianming Chen, Bin Zeng, Zhe Zhang

Journal: World J Microbiol Biotechnol

PubMed ID: 34240255

Doi: 10.1007/s11274-021-03100-8

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Rapid and cost-effective process based on insect larvae for scale-up production of SARS-COV-2 spike protein for serological COVID-19 testing

Authors: Ignacio Smith, Gregorio Juan Mc Callum, Adriana Victoria Sabljic, Juan Ignacio Marfia, Silvina Sonia Bombicino, Aldana Trabucchi, Ruben Francisco Iacono, Joaquín Manuel Birenbaum, Susana Claudia Vazquez, Juan Mauricio Minoia, Osvaldo Cascone, María Gabriela López, Oscar Taboga, Alexandra Marisa Targovnik, Federico Javier Wolman, Matías Fingermann, Leonardo Gabriel Alonso, Silvina Noemí Valdez, María Victoria Miranda

Journal: Biotechnol Bioeng

PubMed ID: 34264519

Doi: 10.1002/bit.27889

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Absence of SARS-CoV-2 Antibodies in Natural Environment Exposure in Sheep in Close Contact with Humans

Authors: Sergio Villanueva-Saz, Jacobo Giner, Antonio Fernández, Delia Lacasta, Aurora Ortín, Juan José Ramos, Luis Miguel Ferrer, Marta Ruiz de Arcaute, Ana Pilar Tobajas, María Dolores Pérez, Maite Verde, Diana Marteles, Ramón Hurtado-Guerrero, Julián Pardo, Llipsy Santiago, Andrés Manuel González-Ramírez, Javier Macías-León, Ana García-García, Víctor Taleb, Erandi Lira-Navarrete, José Ramón Paño-Pardo, Héctor Ruíz

Journal: Animals (Basel)

PubMed ID: 34359111

Doi: 10.3390/ani11071984

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The Knockdown of Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon Downregulation

Authors: Lidong Wang, Ying Zhang, Jiapeng Yang, Lei Liu, Baiyu Yao, Zhong Tian, Jingni He

Journal: DNA Cell Biol

PubMed ID: 34283663

Doi: 10.1089/dna.2021.0216

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m(6)A Modification of lncRNA NEAT1 Regulates Chronic Myelocytic Leukemia Progression miR-766-5p/CDKN1A Axis

Authors: Fang-Yi Yao, Cui Zhao, Fang-Min Zhong, Ting-Yu Qin, Fang Wen, Mei-Yong Li, Jing Liu, Bo Huang, Xiao-Zhong Wang

Journal: Front Oncol

PubMed ID: 34354942

Doi: 10.3389/fonc.2021.679634

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Structure of respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Authors: Piotr Kolata, Rouslan G Efremov

Journal: Elife

PubMed ID: 34308841

Doi: 10.7554/eLife.68710

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Depolymerization of biorefinery lignin by improved laccases of the white-rot fungus Obba rivulosa

Authors: Janne Wallenius, Jussi Kontro, Christina Lyra, Jaana Kuuskeri, Xing Wan, Mika A Kähkönen, Irshad Baig, Paul C J Kamer, Jussi Sipilä, Miia R Mäkelä, Paula Nousiainen, Kristiina Hildén

Journal: Microb Biotechnol

PubMed ID: 34310858

Doi: 10.1111/1751-7915.13896

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Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN

Authors: Wenying Gao, Zhenglong Jin, Yanxia Zheng, Youjia Xu

Journal: Mol Med Rep

PubMed ID: 34278468

Doi: 10.3892/mmr.2021.12291

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Multiple neuronal networks coordinate mechanosensory behavior

Authors: Krishna N Badhiwala, Abby S Primack, Celina E Juliano, Jacob T Robinson

Journal: Elife

PubMed ID: 34328079

Doi: 10.7554/eLife.64108

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Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture

Authors: Julia Nörpel, Simone Cavadini, Andreas D Schenk, Alexandra Graff-Meyer, Daniel Hess, Jan Seebacher, Jeffrey A Chao, Varun Bhaskar

Journal: PLoS Biol

PubMed ID: 34297726

Doi: 10.1371/journal.pbio.3001344

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Observing reorientation dynamics with Time-Resolved fluorescence and molecular dynamics in varying periodic boundary conditions

Authors: Gouri S Jas, Ed W Childs, C Russell Middaugh, Krzysztof Kuczera

Journal: J Biomol Struct Dyn

PubMed ID: 34308794

Doi: 10.1080/07391102.2021.1947894

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Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

Authors: Yongbing Pan, Jianhui Du, Jia Liu, Hai Wu, Fang Gui, Nan Zhang, Xiaojie Deng, Gang Song, Yufeng Li, Jia Lu, Xiaoli Wu, ShanShan Zhan, Zhaofei Jing, Jiong Wang, Yimin Yang, Jianbang Liu, Ying Chen, Qin Chen, Huanyu Zhang, Hengrui Hu, Kai Duan, Manli Wang, Qisheng Wang, Xiaoming Yang

Journal: Cell Discov

PubMed ID: 34315862

Doi: 10.1038/s41421-021-00295-w

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Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Authors: Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M T Burgering

Journal: Cell Rep

PubMed ID: 34320339

Doi: 10.1016/j.celrep.2021.109446

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Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing

Authors: Shanshan Cheng, Yuqian Shen, Zi Chao Zhang, Junhai Han

Journal: STAR Protoc

PubMed ID: 34337444

Doi: 10.1016/j.xpro.2021.100679

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A novel larval diet interacts with nutritional stress to modify juvenile behaviors and glucocorticoid responses

Authors: Cristina C Ledón-Rettig, Sarah R Lagon

Journal: Ecol Evol

PubMed ID: 34429887

Doi: 10.1002/ece3.7860

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Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk

Authors: Chathura D Suraweera , Mark G Hinds , Marc Kvansakul

Journal: Viruses

PubMed ID: 34372579

Doi: 10.3390/v13071374

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Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway

Authors: Jian Cheng , Xiao Wang, Xiaonan Liu , Xiaoxi Zhu , Zihe Li , Huanyu Chu , Qian Wang , QianQian Lou , Bijun Cai , Yiqun Yang , Xiaoyun Lu , Kai Peng , Dingyu Liu , Yuwan Liu , Lina Lu , Huan Liu , Ting Yang , Qijin Ge , Chengcheng Shi , Guichun Liu , Zhiwei Dong , Xun Xu , Wen Wang , Huifeng Jiang , Yanhe Ma

Journal: Mol Plant

PubMed ID: 33951484

Doi: 10.1016/j.molp.2021.04.015

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Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)

Authors: Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko, Liliana Torcoroma García

Journal: BMC Complement Med Ther

PubMed ID: 34215249

Doi: 10.1186/s12906-021-03347-6

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Evidence for a chromosome origin unwinding system broadly conserved in bacteria

Authors: Simone Pelliciari, Mei-Jing Dong, Feng Gao, Heath Murray

Journal: Nucleic Acids Res

PubMed ID: 34197592

Doi: 10.1093/nar/gkab560

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Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine

Authors: Kelly L Hawley, Jairo M Montezuma-Rusca, Kristina N Delgado, Navreeta Singh, Vladimir N Uversky, Melissa J Caimano, Justin D Radolf, Amit Luthra

Journal: J Bacteriol

PubMed ID: 33972353

Doi: 10.1128/JB.00082-21

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Genetic Code Expansion: A Brief History and Perspective

Authors: Mia A Shandell, Zhongping Tan, Virginia W Cornish

Journal: Biochemistry

PubMed ID: 34196546

Doi: 10.1021/acs.biochem.1c00286

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Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Authors: Jun-Ichi Kashiwakura, Nao Koizumi, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Shoya Kawahara, Yukie Yamauchi, Yuichi Kitai, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda

Journal: Biochem Biophys Res Commun

PubMed ID: 34358967

Doi: 10.1016/j.bbrc.2021.07.098

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Optimizing the Expression and Solubilization of an E coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice

Authors: Nahid Mehri, Abbas Jamshidizad, Zahra Ghanei, Ali-Asghar Karkhane, Mehdi Shamsara

Journal: Mol Biotechnol

PubMed ID: 34272681

Doi: 10.1007/s12033-021-00369-w

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Characterization of gH/gL/pUL128-131 pentameric complex, gH/gL/gO trimeric complex, gB and gM/gN glycoproteins in a human cytomegalovirus using automated capillary western blots

Authors: Richard R Rustandi, John W Loughney, Liang Shang, Shiyi Wang, Cindy J Pauley, Sianny Christanti, Adam Kristopeit, Timothy D Culp

Journal: Vaccine

PubMed ID: 34229890

Doi: 10.1016/j.vaccine.2021.06.033

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Altered chromatin architecture and gene expression during polyploidization and domestication of soybean

Authors: Longfei Wang, Guanghong Jia, Xinyu Jiang, Shuai Cao, Z Jeffrey Chen, Qingxin Song

Journal: Plant Cell

PubMed ID: 33730165

Doi: 10.1093/plcell/koab081

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The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid

Authors: Simona Dedoni, Luisa Marras, Maria C Olianas, Angela Ingianni, Pierluigi Onali

Journal: Int J Mol Sci

PubMed ID: 34360553

Doi: 10.3390/ijms22157790

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Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

Authors: Yen-Chin Liu, Bobo Wing-Yee Mok, Pui Wang, Rei-Lin Kuo, Honglin Chen, Shin-Ru Shih

Journal: MBio

PubMed ID: 34311580

Doi: 10.1128/mBio.00945-21

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Functional expression of the eukaryotic proton pump rhodopsin OmR2 in Escherichia coli and its photochemical characterization

Authors: Masuzu Kikuchi, Keiichi Kojima, Shin Nakao, Susumu Yoshizawa, Shiho Kawanishi, Atsushi Shibukawa, Takashi Kikukawa, Yuki Sudo

Journal: Sci Rep

PubMed ID: 34285294

Doi: 10.1038/s41598-021-94181-w

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CTP and coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

Authors: James A Taylor, Yeonee Seol, Jagat Budhathoki, Keir C Neuman, Kiyoshi Mizuuchi

Journal: Elife

PubMed ID: 34286695

Doi: 10.7554/eLife.65651

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The circadian clock gates adult emergence by controlling the timecourse of metamorphosis

Authors: Brandon Mark, Liliana Bustos-González, Guadalupe Cascallares, Felipe Conejera, John Ewer

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34183412

Doi: 10.1073/pnas.2023249118

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Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes

Authors: Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P M Labib

Journal: Biochem J

PubMed ID: 34195792

Doi: 10.1042/BCJ20210315

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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D

Authors: Yonglan Wang, Kun Cao

Journal: J Immunol Res

PubMed ID: 34307695

Doi: 10.1155/2021/9965099

Structural and immunological characterization of an epitope within the PAN motif of ectodomain I in apical membrane antigen 1 for vaccine development

Authors: Amarin Rittipornlertrak, Boondarika Nambooppha, Anucha Muenthaisong, Veerasak Punyapornwithaya, Saruda Tiwananthagorn, Yang-Tsung Chung, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Nattawooti Sthitmatee

Journal: PeerJ

PubMed ID: 34316404

Doi: 10.7717/peerj.11765

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Identification of Three Clf-Sdr Subfamily Proteins in , and Comparative Genomics Analysis of a Locus Encoding CWA Proteins in Species

Authors: Zhewei Sun, Xueya Zhang, Danying Zhou, Kexin Zhou, Qiaoling Li, Hailong Lin, Wei Lu, Hongmao Liu, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Mei Zhu, Qiyu Bao, Hailin Zhang

Journal: Front Microbiol

PubMed ID: 34394031

Doi: 10.3389/fmicb.2021.691087

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The enhanced phosphorus use efficiency in phosphate-deficient and mycorrhiza-inoculated barley seedlings involves activation of different sets of PHT1 transporters in roots

Authors: Rajat Srivastava, Parul Sirohi, Harsh Chauhan, Rahul Kumar

Journal: Planta

PubMed ID: 34312721

Doi: 10.1007/s00425-021-03687-0

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Global Profiling of Phosphorylation Reveals the Barley Roots Response to Phosphorus Starvation and Resupply

Authors: Zengke Ma, Juncheng Wang, Chengdao Li, Panrong Ren, Lirong Yao, Baochun Li, Yaxiong Meng, Xiaole Ma, Erjing Si, Ke Yang, Xunwu Shang, Huajun Wang

Journal: Front Plant Sci

PubMed ID: 34335649

Doi: 10.3389/fpls.2021.676432

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AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment

Authors: Yue Yu, Shu-Ming Ye, De-Yun Liu, Li-Qi Yang

Journal: Exp Anim

PubMed ID: 34305077

Doi: 10.1538/expanim.21-0056

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CABE-RY: A PAM-flexible dual-mutation base editor for reliable modeling of multi-nucleotide variants

Authors: Wanyu Tao, Qing Liu, Shisheng Huang, Xin Wang, Shiyuan Qu, Junfan Guo, Danfeng Ou, Guanglei Li, Yu Zhang, Xiangmin Xu, Xingxu Huang

Journal: Mol Ther Nucleic Acids

PubMed ID: 34513298

Doi: 10.1016/j.omtn.2021.07.016

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Characterization of the Role of the Neoxanthin Synthase Gene in Carotenoid Biosynthesis in Chinese Kale

Authors: Yue Jian, Chenlu Zhang, Yating Wang, Zhiqing Li, Jing Chen, Wenting Zhou, Wenli Huang, Min Jiang, Hao Zheng, Mengyao Li, Huiying Miao, Fen Zhang, Huanxiu Li, Qiaomei Wang, Bo Sun

Journal: Genes (Basel)

PubMed ID: 34440295

Doi: 10.3390/genes12081122

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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle

Authors: Yuanyuan Yu, Qingyun Zheng, Satchal K Erramilli, Man Pan, Seongjin Park, Yuan Xie, Jingxian Li, Jingyi Fei, Anthony A Kossiakoff, Lei Liu, Minglei Zhao

Journal: Nat Chem Biol

PubMed ID: 34239127

Doi: 10.1038/s41589-021-00823-5

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Muscone suppresses gastric cancer via regulation of miRNA-145

Authors: Feng Gao, Shihai Yan, Zheng Sun, Jia Wang

Journal: Food Sci Nutr

PubMed ID: 34531985

Doi: 10.1002/fsn3.2269

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The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach

Authors: Sergio Romero-Romero, Miguel Costas, Daniel-Adriano Silva Manzano, Sina Kordes, Erendira Rojas-Ortega, Cinthya Tapia, Yasel Guerra, Sooruban Shanmugaratnam, Adela Rodríguez-Romero, David Baker, Birte Höcker, D Alejandro Fernández-Velasco

Journal: J Mol Biol

PubMed ID: 34271011

Doi: 10.1016/j.jmb.2021.167153

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A Cas12a-based CRISPR interference system for multigene regulation in mycobacteria

Authors: Neil Fleck, Christoph Grundner

Journal: J Biol Chem

PubMed ID: 34298016

Doi: 10.1016/j.jbc.2021.100990

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Longitudinal evaluation of laboratory-based serological assays for SARS-CoV-2 antibody detection

Authors: K A Bond, E Williams, S Nicholson, S Lim, D Johnson, B Cox, M Putland, E Gardiner, E Tippett, M Graham, F Mordant, M Catton, S R Lewin, K Subbarao, B P Howden, D A Williamson

Journal: Pathology

PubMed ID: 34412859

Doi: 10.1016/j.pathol.2021.05.093

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Fast and reliable detection of SARS-CoV-2 antibodies based on surface plasmon resonance

Authors: Caroline Rodrigues Basso, Camila Dantas Malossi, Amanda Haisi, Valber de Albuquerque Pedrosa, Alexandre Naime Barbosa, Rejane Tommasini Grotto, João Pessoa Araujo Junior

Journal: Anal Methods

PubMed ID: 34231576

Doi: 10.1039/d1ay00737h

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Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes

Authors: Lucas F de Lima, André L Ferreira, Marcelo D T Torres, William R de Araujo, Cesar de la Fuente-Nunez

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34244421

Doi: 10.1073/pnas.2106724118

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Selective Inhibitors of the Inducible Nitric Oxide Synthase as Modulators of Cell Responses in LPS-Stimulated Human Monocytes

Authors: Marialucia Gallorini, Monica Rapino, Helmut Schweikl, Amelia Cataldi, Rosa Amoroso, Cristina Maccallini

Journal: Molecules

PubMed ID: 34361571

Doi: 10.3390/molecules26154419

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Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling

Authors: Hui-Hui Wang, Jia-Ni Ma, Xiao-Rong Zhan

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34290668

Doi: 10.3389/fendo.2021.670031

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CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells

Authors: Raviteja Inturi, Per Jemth

Journal: Virology

PubMed ID: 34280810

Doi: 10.1016/j.virol.2021.07.005

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Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection

Authors: José Javier Morales-Núñez, José Francisco Muñoz-Valle, Carlos Meza-López, Lin-Fa Wang, Andrea Carolina Machado Sulbarán, Paola Carolina Torres-Hernández, Martín Bedolla-Barajas, Brenda De la O-Gómez, Paulina Balcázar-Félix, Jorge Hernández-Bello

Journal: Vaccines (Basel)

PubMed ID: 34358158

Doi: 10.3390/vaccines9070742

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