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Combined 4-1BB and ICOS co-stimulation improves anti-tumor efficacy and persistence of dual anti-CD19/CD20 chimeric antigen receptor T cells

Authors: Ying Wang, Kailun Zhong, Jun Ke, Xi Chen, Yi Chen, Wangyun Shu, Chunhuan Chen, Shan Hu, Xiaoke Sun, Haibin Huang, Chong Luo, Lifang Liu, Jiaming Yang, Yongke Zhang, Huijun Zhi

Journal: Cytotherapy

PubMed ID: 33863641

Doi: 10.1016/j.jcyt.2021.02.117

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Glutamate-Putrescine Ligase Activity in : A New Function for Gene

Authors: Verónica Rodríguez-Herrero, Arnau Peris, Mónica Camacho, Vanesa Bautista, Julia Esclapez, María-José Bonete

Journal: Biomolecules

PubMed ID: 34439822

Doi: 10.3390/biom11081156

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Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

Authors: Erica M Briggs, Paolo Mita, Xiaoji Sun, Susan Ha, Nikita Vasilyev, Zev R Leopold, Evgeny Nudler, Jef D Boeke, Susan K Logan

Journal: Mob DNA

PubMed ID: 34425899

Doi: 10.1186/s13100-021-00249-9

Products & Services: Plasmid DNA Preparation

Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease

Authors: Peter Simons, Yan Guo, Virginie Bondu, Susan L Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A Lawrence, Tione Buranda

Journal: Viruses

PubMed ID: 34452463

Doi: 10.3390/v13081597

Products & Services: Plasmid DNA Preparation

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

Authors: Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-Mao Xia, Mattia Bonsignori, David Montefiori, Qifeng Han, Sravani Venkatayogi, Tyler Evangelous, Yunfei Wang, Wes Rountree, Ying Tam, Christopher Barbosa, S Munir Alam, Wilton B Williams, Norbert Pardi, Drew Weissman, Barton F Haynes

Journal: biorxiv

PubMed ID: 34401876

Doi: 10.1101/2021.08.09.455714

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A truncated glycoprotein G vaccine formulated with Advax-CpG adjuvant provides protection of mice against genital herpes simplex virus 2 infection

Authors: Staffan Görander, Yoshikazu Honda-Okubo, Malin Bäckström, Jeremy Baldwin, Tomas Bergström, Nikolai Petrovsky, Jan-Åke Liljeqvist

Journal: Vaccine

PubMed ID: 34456075

Doi: 10.1016/j.vaccine.2021.08.050

Products & Services: Plasmid DNA Preparation

DNA-guided photoactivatable probe-based chemical proteomics reveals the reader protein of mRNA methylation

Authors: Yepei Huang, Xue Bai, Zhenchang Guo, Hanyang Dong, Yun Fu, Hui Zhang, Guijin Zhai, Shanshan Tian, Ye Wang, Kai Zhang

Journal: iScience

PubMed ID: 34553132

Doi: 10.1016/j.isci.2021.103046

Products & Services: Plasmid DNA Preparation

Interaction of Antimicrobial Peptide Ponericin W1, Thanatin, and Mastatopara-S with Genomic DNA

Authors: Hongyan Zhang, Sha Liu, Xindan Li, Wenjun Wang, Lili Deng, Kaifang Zeng

Journal: Foods

PubMed ID: 34441696

Doi: 10.3390/foods10081919

Products & Services: Peptide Tools

Optimization of antigen-specific CD8 T cell activation conditions for infectious diseases including COVID-19

Authors: Chanchan Xiao, Congling Qiu, Jieping Deng, Jiezhou Ye, Lijuan Gao, Jun Su, Oscar Junhong Luo, Pengcheng Wang, Guobing Chen

Journal: STAR Protoc

PubMed ID: 34414379

Doi: 10.1016/j.xpro.2021.100789

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Dual concentration-dependent effect of ascorbic acid on PAP(248-286) amyloid formation and SEVI-mediated HIV infection

Authors: Satabdee Mohapatra, Guru Krishna Kumar Viswanathan, Lukas Wettstein, Elad Arad, Ashim Paul, Vijay Kumar, Raz Jelinek, Jan Münch, Daniel Segal

Journal: RSC Chem Biol

PubMed ID: 34704058

Doi: 10.1039/d1cb00084e

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Targeted genetic screening in bacteria with a Cas12k-guided transposase

Authors: Weizhong Chen, Ze-Hui Ren, Na Tang, Guoshi Chai, Hongyuan Zhang, Yifei Zhang, Jiacheng Ma, Zhaowei Wu, Xia Shen, Xingxu Huang, Guan-Zheng Luo, Quanjiang Ji

Journal: Cell Rep

PubMed ID: 34469724

Doi: 10.1016/j.celrep.2021.109635

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Vaccination against the Protozoan Parasite Primes the Activation of Toll-like Receptors in Turkeys and Chickens Determined by a Set of Newly Developed Multiplex RT-qPCRs

Authors: Taniya Mitra, Beatrice Bramberger, Ivana Bilic, Michael Hess, Dieter Liebhart

Journal: Vaccines (Basel)

PubMed ID: 34579197

Doi: 10.3390/vaccines9090960

Products & Services: ORF cDNA Clones/MolecularCloud

Downregulation of miR-1-3p expression inhibits the hypertrophy and mineralization of chondrocytes in DDH

Authors: Rui Ding, Xijuan Liu, Jian Zhang, Jinghong Yuan, Sikuan Zheng, Xigao Cheng, Jingyu Jia

Journal: J Orthop Surg Res

PubMed ID: 34407854

Doi: 10.1186/s13018-021-02666-1

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Mapping human calreticulin regions important for structural stability

Authors: Evaldas Čiplys, Tautvydas Paškevičius, Eimantas Žitkus, Juras Bielskis, Raimundas Ražanskas, Tomas Šneideris, Vytautas Smirnovas, Algirdas Kaupinis, David J Tester, Michael J Ackerman, Peter Højrup, Marek Michalak, Gunnar Houen, Rimantas Slibinskas

Journal: Biochim Biophys Acta Proteins Proteom

PubMed ID: 34358706

Doi: 10.1016/j.bbapap.2021.140710

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Inhibition of Border Disease Virus Replication With Lentivirus-Mediated shRNAs

Authors: Mohammad Javad Hajihasani Arani, Azam Mokhtari, Behnaz Saffar, Leila Asadi Samani

Journal: Front Vet Sci

PubMed ID: 34447803

Doi: 10.3389/fvets.2021.708591

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Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells

Authors: Konrad Klockmeier, Eduardo Silva Ramos, Tamás Raskó, Adrián Martí Pastor, Erich E Wanker

Journal: J Mol Biol

PubMed ID: 34364876

Doi: 10.1016/j.jmb.2021.167184

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Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

Authors: Chee-Wah Tan, Wan-Ni Chia, Barnaby E Young, Feng Zhu, Beng-Lee Lim, Wan-Rong Sia, Tun-Linn Thein, Mark I-C Chen, Yee-Sin Leo, David C Lye, Lin-Fa Wang

Journal: N Engl J Med

PubMed ID: 34407341

Doi: 10.1056/NEJMoa2108453

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Early warning and rapid public health response to prevent COVID-19 outbreaks in long-term care facilities (LTCF) by monitoring SARS-CoV-2 RNA in LTCF site-specific sewage samples and assessment of antibodies response in this population: prospective study protocol

Authors: Bonita E Lee, Christopher Sikora, Douglas Faulder, Eleanor Risling, Lorie A Little, Yuanyuan Qiu, Tiejun Gao, Ross Bulat, Stephen Craik, Steve E Hrudey, Arto Ohinmaa, Carole A Estabrooks, Anne-Claude Gingras, Carmen Charlton, John Kim, Heidi Wood, Alyssia Robinson, Jamil N Kanji, Nathan Zelyas, Sheila F O'Brien, Steven Drews, Xiao-Li Pang

Journal: BMJ Open

PubMed ID: 34417219

Doi: 10.1136/bmjopen-2021-052282

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Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains

Authors: Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Hae-Ahm Lee, Eun-Kyung Moon, Beom-Ku Han, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 34452044

Doi: 10.3390/vaccines9080920

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Metabolic Engineering of BD16 for Heterologous Expression of Synthetic Gene Cassette and L-Alanine Production in the Recombinant Strain Using Fed-Batch Fermentation

Authors: Anshula Sharma, Masafumi Noda, Masanori Sugiyama, Baljinder Kaur, Ajaz Ahmad

Journal: Foods

PubMed ID: 34441741

Doi: 10.3390/foods10081964

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miRNA-451 regulates the NF-κB signaling pathway by targeting IKKβ to inhibit glioma cell growth

Authors: Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang

Journal: Cell Cycle

PubMed ID: 34463194

Doi: 10.1080/15384101.2021.1969496

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Litopenaeus vannamei peroxiredoxin 2-like is involved in WSSV infection by interaction with wsv089 and VP26

Authors: Xing-Chao Ren, Xiao-Ping Liu, Qing-Hui Liu

Journal: Dev Comp Immunol

PubMed ID: 34450129

Doi: 10.1016/j.dci.2021.104243

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A continuous spectrophotometric assay for glutathione-independent glyoxalases

Authors: Tomiris Mulikova, Zhanibek Bekkhozhin, Aizat Abdirassil, Darkhan Utepbergenov

Journal: Anal Biochem

PubMed ID: 34391725

Doi: 10.1016/j.ab.2021.114317

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Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP

Authors: Mark Chen, Joseph P Foster, Ian C Lock, Nathan H Leisenring, Andrea R Daniel, Warren Floyd, Eric Xu, Ian J Davis, David G Kirsch

Journal: Cancer Res

PubMed ID: 34385184

Doi: 10.1158/0008-5472.CAN-20-1497

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An ester bond underlies the mechanical strength of a pathogen surface protein

Authors: Hai Lei, Quan Ma, Wenfei Li, Jing Wen, Haibo Ma, Meng Qin, Wei Wang, Yi Cao

Journal: Nat Commun

PubMed ID: 34426584

Doi: 10.1038/s41467-021-25425-6

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Meet the authors: Michael Ranes and Sebastian Guettler

Authors:

Journal: Mol Cell

PubMed ID: 34416135

Doi: 10.1016/j.molcel.2021.08.002

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Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains

Authors: Enya Qing, Tom Kicmal, Binod Kumar, Grant M Hawkins, Emily Timm, Stanley Perlman, Tom Gallagher

Journal: MBio

PubMed ID: 34340537

Doi: 10.1128/mBio.01590-21

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Deep survey for designing a vaccine against SARS-CoV-2 and its new mutations

Authors: Bahareh Vakili, Ashkan Bagheri, Manica Negahdaripour

Journal: Biologia (Bratisl)

PubMed ID: 34421121

Doi: 10.1007/s11756-021-00866-y

Products & Services: Codon Optimization

Compact RNA editors with small Cas13 proteins

Authors: Soumya Kannan, Han Altae-Tran, Xin Jin, Victoria J Madigan, Rachel Oshiro, Kira S Makarova, Eugene V Koonin, Feng Zhang

Journal: Nat Biotechnol

PubMed ID: 34462587

Doi: 10.1038/s41587-021-01030-2

Products & Services: Codon Optimization

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

Authors: Shanshan Ma, Yan Chen, Antao Dai, Wanchao Yin, Jia Guo, Dehua Yang, Fulai Zhou, Yi Jiang, Ming-Wei Wang, H Eric Xu

Journal: Cell Res

PubMed ID: 34453129

Doi: 10.1038/s41422-021-00557-y

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Structure of the Human Cholesterol Transporter ABCG1

Authors: Liga Skarda, Julia Kowal, Kaspar P Locher

Journal: J Mol Biol

PubMed ID: 34461069

Doi: 10.1016/j.jmb.2021.167218

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Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis

Authors: Guilherme Caetano Garcia, Ana Maria Ravena Severino Carvalho, Mariana Costa Duarte, Matheus Fernandes Costa E Silva, Fernanda Alvarenga Cardoso Medeiros, Eduardo Antonio Ferraz Coelho, Dênia Monteiro de Moura Franco, Denise Utsch Gonçalves, Tiago Antônio de Oliveira Mendes, Daniel Menezes-Souza

Journal: Appl Microbiol Biotechnol

PubMed ID: 34432132

Doi: 10.1007/s00253-021-11518-1

Products & Services: Bacterial Expression

Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux

Authors: Lin Lin, Junyu Chen, Ruchira Mitra, Quanxiu Gao, Feiyue Cheng, Tong Xu, Zhenqiang Zuo, Hua Xiang, Jing Han

Journal: Commun Biol

PubMed ID: 34433872

Doi: 10.1038/s42003-021-02541-z

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RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers

Authors: Hannah G Abraham, Peter J Ulintz, Laura Goo, Joel A Yates, Andrew C Little, Liwei Bao, Zhifen Wu, Sofia D Merajver

Journal: Front Oncol

PubMed ID: 34513691

Doi: 10.3389/fonc.2021.712041

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Expressing Type I Interferon From Atlantic Salmon Enhances the Innate Antiviral Immune Response and

Authors: Carlos Muñoz, Josue González-Lorca, Mick Parra, Sarita Soto, Natalia Valdes, Ana María Sandino, Rodrigo Vargas, Alex González, Mario Tello

Journal: Front Immunol

PubMed ID: 34475871

Doi: 10.3389/fimmu.2021.696781

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Identifying the Basis for VirS/VirR Two-Component Regulatory System Control of Clostridium perfringens Beta-Toxin Production

Authors: Iman Mehdizadeh Gohari, Jihong Li, Bruce A McClane

Journal: J Bacteriol

PubMed ID: 34228498

Doi: 10.1128/JB.00279-21

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A novel RNA detection technique for point-of-care identification of pathogens

Authors: Mekbib Astatke, Olivia Tiburzi, Amy Connolly

Journal: J Immunoassay Immunochem

PubMed ID: 34355634

Doi: 10.1080/15321819.2021.1955380

Products & Services: Gene Synthesis

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Authors: Qingqing Chai, Sunan Li, Morgan K Collins, Rongrong Li, Iqbal Ahmad, Silas F Johnson, Dylan A Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F Hultquist, B Matija Peterlin, Yong-Hui Zheng

Journal: Cell Rep

PubMed ID: 34380030

Doi: 10.1016/j.celrep.2021.109514

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Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

Authors: Olivia Swanson, Brianna Rhodes, Avivah Wang, Shi-Mao Xia, Robert Parks, Haiyan Chen, Aja Sanzone, Melissa Cooper, Mark K Louder, Bob C Lin, Nicole A Doria-Rose, Mattia Bonsignori, Kevin O Saunders, Kevin Wiehe, Barton F Haynes, Mihai L Azoitei

Journal: Cell Rep

PubMed ID: 34407396

Doi: 10.1016/j.celrep.2021.109561

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Genome editing with CRISPR/Cas9 in Pinus radiata (D. Don)

Authors: Charleson Poovaiah, Lorelle Phillips, Barbara Geddes, Cathie Reeves, Mathias Sorieul and Glenn Thorlby

Journal: BMC Plant Biology

PubMed ID: 34376154

Doi: 10.1186/s12870-021-03143-x

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GRB2 enforces homology-directed repair initiation by MRE11.

Authors: Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G Leonard, Darin E Jones, Bin Wang, John A Tainer, Zamal Ahmed

Journal: Sci Adv

Doi: 10.1126/sciadv.abe9254

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Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Authors: Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang

Journal: Nat Commun.

PubMed ID: 34417468

Doi: 10.1038/s41467-021-25364-2

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An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury

Authors: Huy Q Le, Matthew A Hill, Ines Kollak, Martina Keck, Victoria Schroeder, Johannes Wirth, Wioletta Skronska-Wasek, Eva Schruf, Benjamin Strobel, Heiko Stahl, Franziska E Herrmann, Alexandre R Campos, Jun Li, Karsten Quast, Dagmar Knebel, Coralie Viollet, Matthew J Thomas, David Lamb, James P Garnett

Journal: EMBO Rep

PubMed ID: 34224201

Doi: 10.15252/embr.202152785

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Rapid CRISPR/Cas9 Editing of Genotype IX African Swine Fever Virus Circulating in Eastern and Central Africa

Authors: Hussein M Abkallo, Nicholas Svitek, Bernard Oduor, Elias Awino, Sonal P Henson, Samuel O Oyola, Stephen Mwalimu, Nacrya Assad-Garcia, Walter Fuchs, Sanjay Vashee, Lucilla Steinaa

Journal: Front Genet

PubMed ID: 34527025

Doi: 10.3389/fgene.2021.733674

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Three-layered control of mRNA poly(A) tail synthesis in

Authors: Matti Turtola, M Cemre Manav, Ananthanarayanan Kumar, Agnieszka Tudek, Seweryn Mroczek, Paweł S Krawczyk, Andrzej Dziembowski, Manfred Schmid, Lori A Passmore, Ana Casañal, Torben Heick Jensen

Journal: Genes Dev

PubMed ID: 34385261

Doi: 10.1101/gad.348634.121

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Comprehensive Proteome and Lysine Acetylome Analysis Reveals the Widespread Involvement of Acetylation in Cold Resistance of Pepper ( L)

Authors: Zhoubin Liu, Jingshuang Song, Wu Miao, Bozhi Yang, Zhuqing Zhang, Wenchao Chen, Fangjun Tan, Huan Suo, Xiongze Dai, Xuexiao Zou, Lijun Ou

Journal: Front Plant Sci

PubMed ID: 34512705

Doi: 10.3389/fpls.2021.730489

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Human Cystathionine γ-Lyase Is Inhibited by -Nitrosation: A New Crosstalk Mechanism between NO and HS

Authors: Dalila G F Fernandes, João Nunes, Catarina S Tomé, Karim Zuhra, João M F Costa, Alexandra M M Antunes, Alessandro Giuffrè, João B Vicente

Journal: Antioxidants (Basel)

PubMed ID: 34573023

Doi: 10.3390/antiox10091391

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DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks

Authors: Albert W Hinman, Hsin-Yi Yeh, Baptiste Roelens, Kei Yamaya, Alexander Woglar, Henri-Marc G Bourbon, Peter Chi, Anne M Villeneuve

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34389685

Doi: 10.1073/pnas.2109306118

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Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity

Authors: Wuji Zhang, Brendon Chua, Kevin Selva, Lukasz Kedzierski, Thomas Ashhurst, Ebene Haycroft, Suzanne Shoffner, Luca Hensen, David Boyd, Fiona James, Effie Mouhtouris, Jason Kwong, Kyra Chua, George Drewett, Ana Copaescu, Julie Dobson, Louise Rowntree, Jennifer Habel, Lilith Allen, Hui-Fern Koay, Jessica Neil, Matthew Gartner, Christina Lee, Patiyan Andersson, Torsten Seemann, Norelle Sherry, Fatima Amanat, Florian Krammer, Sarah Londrigan, Linda Wakim, Nicholas King, Dale Godfrey, Laura Mackay, Paul Thomas, Suellen Nicholson, Kelly Arnold, Amy Chung, Natasha Holmes, Olivia Smibert, Jason Trubiano, Claire Gordon, Thi Nguyen, Katherine Kedzierska

Journal: Res Sq

PubMed ID: 34462740

Doi: 10.21203/rs.3.rs-802084/v1

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

Authors: Miao Jiang, Pekka Kolehmainen, Laura Kakkola, Sari Maljanen, Krister Melén, Teemu Smura, Ilkka Julkunen, Pamela Österlund

Journal: Microbiol Spectr

PubMed ID: 34378952

Doi: 10.1128/Spectrum.00774-21

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A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies

Authors: Ian C Michelow, Sangshin Park, Shu-Whei Tsai, Bonnie Rayta, Charisse Flerida A Pasaje, Sara Nelson, Angela M Early, Anne P Frosch, George Ayodo, Dipak K Raj, Christina E Nixon, Christian P Nixon, Sunthorn Pond-Tor, Jennifer F Friedman, Michal Fried, Patrick E Duffy, Karine G Le Roch, Jacquin C Niles, Jonathan D Kurtis

Journal: J Exp Med

PubMed ID: 34342640

Doi: 10.1084/jem.20200170

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compensates for in mice in the amino-terminal acetylation pathway

Authors: Hyae Yon Kweon, Mi-Ni Lee, Max Dorfel, Seungwoon Seo, Leah Gottlieb, Thomas PaPazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael Flory, Jonathan Crain, Alison Sebold, Scott Lyons, Ahmed Ismail, Elaine Marchi, Seong-Keun Sonn, Se-Jin Jeong, Sejin Jeon, Shinyeong Ju, Simon J Conway, Taesoo Kim, Hyun-Seok Kim, Cheolju Lee, Tae-Young Roh, Thomas Arnesen, Ronen Marmorstein, Goo Taeg Oh, Gholson J Lyon

Journal: Elife

PubMed ID: 34355692

Doi: 10.7554/eLife.65952

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Conformational equilibria in allosteric control of Hsp70 chaperones

Authors: Wei Wang, Qinglian Liu, Qun Liu, Wayne A Hendrickson

Journal: Mol Cell

PubMed ID: 34453889

Doi: 10.1016/j.molcel.2021.07.039

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Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease

Authors: Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E Andersen, Johannes J Sidelmann, Mark D Inman, Salvatore V Pizzo, Bo Gao, Joan C Krepinsky

Journal: Biomedicines

PubMed ID: 34572299

Doi: 10.3390/biomedicines9091112

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Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis

Authors: Mengyan Zhang, Weiguo Zhu, Mansour Haeryfar, Sumei Jiang, Xiang Jiang, Wei Chen, Jiancheng Li

Journal: Onco Targets Ther

PubMed ID: 34408438

Doi: 10.2147/OTT.S297336

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Ion Transport Activity Assay for Microbial Rhodopsin Expressed in Cells

Authors: Masae Konno, Keiichi Inoue, Hideki Kandori

Journal: Bio Protoc

PubMed ID: 34458409

Doi: 10.21769/BioProtoc.4115

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Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

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Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of "Two-Site" Binding Paradigm

Authors: Aurosikha Das, Lalita Mohan Behera, Soumendra Rana

Journal: ACS Omega

PubMed ID: 34514259

Doi: 10.1021/acsomega.1c03400

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Engineering analysis of multienzyme cascade reactions for 3'-sialyllactose synthesis

Authors: Sabine Schelch, Manuel Eibinger, Stefanie Gross Belduma, Barbara Petschacher, Jürgen Kuballa, Bernd Nidetzky

Journal: Biotechnol Bioeng

PubMed ID: 34289079

Doi: 10.1002/bit.27898

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Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System?

Authors: Audrey J Muscato, Patrick Walsh, Sovannarath Pong, Alixander Pupo, Roni J Gross, Andrew E Christie, J Joe Hull, Patsy S Dickinson

Journal: Int J Mol Sci

PubMed ID: 34445418

Doi: 10.3390/ijms22168703

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Genome-Wide Identification and Characterization of KNOTTED-Like Homeobox (KNOX) Homologs in Garlic ( L) and Their Expression Profilings Responding to Exogenous Cytokinin and Gibberellin

Authors: Siyu Zhang, Yupeng Pan, Chengchen Zhi, Yujie Zheng, Xi'ao Wang, Xiaxia Li, Zhihui Cheng

Journal: Int J Mol Sci

PubMed ID: 34502163

Doi: 10.3390/ijms22179237

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Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase

Authors: Huan Chen, Yan Teng, Xingmin Chen, Zhihao Liu, Fan Geng, Yanzhuo Liu, Haisong Jiang, Ziyan Wang, Lu Yang

Journal: CNS Neurosci Ther

PubMed ID: 34346167

Doi: 10.1111/cns.13708

Products & Services: Mammalian Expression

Inhibition of NOD1 Attenuates Neonatal Hypoxia-Ischemia Induced Long-Term Cognitive Impairments in Mice Through Modulation of Autophagy-Related Proteins

Authors: Fang Liu, Mingyu Shao, Feng Xu, Fang Rong

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34421301

Doi: 10.2147/NDT.S314884

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Evidence for UV-green dichromacy in the basal hymenopteran Sirex noctilio (Siricidae)

Authors: Quentin Guignard, Johannes Spaethe, Bernard Slippers, Martin Strube-Bloss, Jeremy D Allison

Journal: Sci Rep

PubMed ID: 34341410

Doi: 10.1038/s41598-021-95107-2

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Objective Measurements Associated with the Preferred Eating Qualities of Fermented Salamis

Authors: Jihan Kim, Scott Knowles, Raise Ahmad, Li Day

Journal: Foods

PubMed ID: 34574113

Doi: 10.3390/foods10092003

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Inhibition of Three Citrus Pathogenic Fungi by Peptide PAF56 Involves Cell Membrane Damage

Authors: Wenjun Wang, Guirong Feng, Xindan Li, Changqing Ruan, Jian Ming, Kaifang Zeng

Journal: Foods

PubMed ID: 34574141

Doi: 10.3390/foods10092031

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CRISPR-mediated Labeling of Cells in Chick Embryos Based on Selectively Expressed Genes

Authors: Masahito Yamagata, Joshua R Sanes

Journal: Bio Protoc

PubMed ID: 34458399

Doi: 10.21769/BioProtoc.4105

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Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Authors: Qingzhuoma Yang, Shengtao Guo, Qi Lu, Yong Tao, Decong Zheng, Qinmao Zhou, Jun Liu

Journal: Biosci Rep

PubMed ID: 34338280

Doi: 10.1042/BSR20211135

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Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia

Authors: Xiaojie Zhang, Soo Jung Lee, Michael M Wang

Journal: Sci Rep

PubMed ID: 34446744

Doi: 10.1038/s41598-021-96679-9

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A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc

Authors: Fei Leng, Yan-Yu Miu, Yi Zhang, Hao Luo, Xiao-Li Lu, Hui Cheng, Zhi-Guo Zheng

Journal: Oncol Lett

PubMed ID: 34457052

Doi: 10.3892/ol.2021.12958

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Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

Authors: Yao Zhou, Diyin Li, Jianhua Luo, Aizhong Chen, Xingxing Li, Zhenrui Pan, Li Wan, Liuqing He, Danyang Li, Yanyan Li , Min Dong, Liang Tao

Journal: Cell Res

PubMed ID: 33972749

Doi: 10.1038/s41422-021-00510-z

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Secreted Expression of mRNA-Encoded Truncated ACE2 Variants for SARS-CoV-2 via Lipid-Like Nanoassemblies

Authors: Min Li, Sanpeng Li, Yixuan Huang, Haixia Chen, Songya Zhang, Zhicheng Zhang, Weigang Wu, Xiaobin Zeng, Boping Zhou, Bin Li

Journal: Adv Mater

PubMed ID: 34278613

Doi: 10.1002/adma.202101707

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3D culture system to study collective migration in mammary organoid epithelium

Authors: Yunzhe Lu, Ruolan Deng, Huanyang You, Pengfei Lu

Journal: STAR Protoc

PubMed ID: 34485944

Doi: 10.1016/j.xpro.2021.100778

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Serological Testing for COVID-19, Immunological Surveillance, and Exploration of Protective Antibodies

Authors: Luis A Peroni, Jessica M Toscaro, Camila Canateli, Celisa C C Tonoli, Renata R de Olivera, Celso E Benedetti, Lais D Coimbra, Alexandre Borin Pereira, Rafael E Marques, José L Proença-Modena, Gabriel C Lima, Renata Viana, Jessica B Borges, Hui Tzu Lin-Wang, Cely S Abboud, Carlos Gun, Kleber G Franchini, Marcio C Bajgelman

Journal: Front Immunol

PubMed ID: 34489923

Doi: 10.3389/fimmu.2021.635701

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Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor

Authors: Daniel Parras, Patricia Solé, Thomas Delong, Pere Santamaría, Pau Serra

Journal: Front Immunol

PubMed ID: 34527002

Doi: 10.3389/fimmu.2021.737428

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Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses

Authors: Bryan S Kaplan, Tavis K Anderson, Jennifer Chang, Jefferson Santos, Daniel Perez, Nicola Lewis, Amy L Vincent

Journal: J Virol

PubMed ID: 34379513

Doi: 10.1128/JVI.00632-21

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A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters

Authors: Mijia Lu, Yuexiu Zhang, Piyush Dravid, Anzhong Li, Cong Zeng, Mahesh Kc, Sheetal Trivedi, Himanshu Sharma, Supranee Chaiwatpongsakorn, Ashley Zani, Adam Kenney, Chuanxi Cai, Chengjin Ye, Xueya Liang, Jianming Qiu, Luis Martinez-Sobrido, Jacob S Yount, Prosper N Boyaka, Shan-Lu Liu, Mark E Peeples, Amit Kapoor, Jianrong Li

Journal: J Virol

PubMed ID: 34379509

Doi: 10.1128/JVI.00592-21

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Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease

Authors: Freja Herborg,Kathrine L. Jensen,Sasha Tolstoy,Natascha V. Arends,Leonie P. Posselt,Aparna Shekar, Jenny I Aguilar, Viktor K. Lund, Kevin Erreger,Mattias Rickhag,Matthew D. Lycas,Markus N. Lonsdale,Troels Rahbek-Clemmensen,Andreas T. Sørensen,Amy H. Newman,Annemette Løkkegaard,Ole Kjaerulff,Thomas Werge,Lisbeth B. Møller,Heinrich J.G. Matthies, Aurelio Galli, Lena E. Hjermind,6 and Ulrik Gether

Journal: JCI Insight

PubMed ID: 34375312

Doi: 10.1172/jci.insight.151496.

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Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro

Authors: Phong Quoc Nguyen , Christine Conesa , Elise Rabut , Gabriel Bragagnolo , Célia Gouzerh , Carlos Fernández-Tornero , Pascale Lesage , Juan Reguera and Jol Acker

Journal: Journal of Biological Chemistry

PubMed ID: 34416236

Doi: 10.1016/j.jbc.2021.101093

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Shrimp Plasma CREG Is a Hemocyte Activation Factor

Authors: Zhiqi Huang, Peng Yang, Fan Wang

Journal: Front Immunol.

PubMed ID: 34484206

Doi: 10.3389/fimmu.2021.707770

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The component of the mA writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors

Authors: Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H J Looijenga, Rui Henrique, Carmen Jerónimo

Journal: J Exp Clin Cancer Res

PubMed ID: 34446080

Doi: 10.1186/s13046-021-02072-9

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Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response

Authors: Laura M Fiori, Massimiliano Orri, Zahia Aouabed, Jean François Théroux, Rixing Lin, Corina Nagy, Benicio N Frey, Raymond W Lam, Glenda M MacQueen, Roumen Milev, Daniel J Müller, Sagar V Parikh, Susan Rotzinger, Rudolf Uher, Jane A Foster, Sidney H Kennedy, Gustavo Turecki

Journal: Transl Psychiatry

PubMed ID: 34420030

Doi: 10.1038/s41398-021-01564-8

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Peptides derived from viral glycoprotein Gc Inhibit infection of severe fever with thrombocytopenia syndrome virus

Authors: Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing

Journal: Antiviral Res

PubMed ID: 34411654

Doi: 10.1016/j.antiviral.2021.105164

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Activation of Local and Systemic Defence Responses by Flg22 Is Dependent on Daytime and Ethylene in Intact Tomato Plants

Authors: Zalán Czékus, András Kukri, Kamirán Áron Hamow, Gabriella Szalai, Irma Tari, Attila Ördög, Péter Poór

Journal: Int J Mol Sci

PubMed ID: 34361121

Doi: 10.3390/ijms22158354

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Performance evaluation of three automated quantitative immunoassays and their correlation with a surrogate virus neutralization test in coronavirus disease 19 patients and pre-pandemic controls

Authors: Kiwook Jung, Sue Shin, Minjeong Nam, Yun Ji Hong, Eun Youn Roh, Kyoung Un Park, Eun Young Song

Journal: J Clin Lab Anal

PubMed ID: 34369009

Doi: 10.1002/jcla.23921

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Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

Authors: William Y Wang, Robert N Kent, Stephanie A Huang, Evan H Jarman, Eve H Shikanov, Christopher D Davidson, Harrison L Hiraki, Daphne Lin, Monica A Wall, Daniel L Matera, Jae-Won Shin, William J Polacheck, Ariella Shikanov, Brendon M Baker

Journal: Acta Biomater

PubMed ID: 34469789

Doi: 10.1016/j.actbio.2021.08.038

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Photoreactive hydrogel stiffness influences volumetric muscle loss repair

Authors: Ivan M Basurto, Juliana A Passipieri, Gregg M Gardner, Kathryn K Smith, Austin R Amacher, Audrey I Hansrisuk, George J Christ, Steven R Caliari

Journal: Tissue Eng Part A

PubMed ID: 34409861

Doi: 10.1089/ten.TEA.2021.0137

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PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model

Authors: Zhihong Sun, Ping Meng, Chunyu Su, Shengmin Ji, Yonglin Gao, Hongbo Wang, Jingwei Tian, Chunmei Li

Journal: Toxicol Appl Pharmacol

PubMed ID: 34428447

Doi: 10.1016/j.taap.2021.115698

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CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer

Authors: Yue Shi, Tao Han, Chong Liu

Journal: Ann Transl Med

PubMed ID: 34532373

Doi: 10.21037/atm-21-2934

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Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures

Authors: Erik Walinda, Daichi Morimoto, Tomoki Sorada, Kazuhiro Iwai, Kenji Sugase

Journal: Protein Expr Purif

PubMed ID: 34390872

Doi: 10.1016/j.pep.2021.105953

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Tracing Clostridium perfringens strains from beef processing of slaughter house by pulsed-field gel electrophoresis, and the distribution and toxinotype of isolates in Shaanxi province, China

Authors: Yanfen Jiang, Yinghui Ma, Qianqian Liu, Tianmei Li, Yiming Li, Kangkang Guo, Yanming Zhang

Journal: Food Microbiol

PubMed ID: 34579847

Doi: 10.1016/j.fm.2021.103887

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N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

Authors: Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng

Journal: Elife

PubMed ID: 34414884

Doi: 10.7554/eLife.69091

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The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end

Authors: Dalibor Kosek, Ivana Grabundzija, Haotian Lei, Ilija Bilic, Huaibin Wang, Yukun Jin, Graham F Peaslee, Alison B Hickman, Fred Dyda

Journal: Mol Cell

PubMed ID: 34403695

Doi: 10.1016/j.molcel.2021.07.028

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Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Authors: Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan

Journal: Viruses

PubMed ID: 34452398

Doi: 10.3390/v13081533

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Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett's esophagus

Authors: Nandan P Deshpande, Stephen M Riordan, Claire J Gorman, Shaun Nielsen, Tonia L Russell, Carolina Correa-Ospina, Bentotage S M Fernando, Shafagh A Waters, Natalia Castaño-Rodríguez, Si Ming Man, Nicodemus Tedla, Marc R Wilkins, Nadeem O Kaakoush

Journal: Genome Med

PubMed ID: 34412659

Doi: 10.1186/s13073-021-00951-6

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Dry-Cured Ham-Derived Peptide (Asp-Leu-Glu-Glu) Exerts Cytoprotective Capacity in Human Intestinal Epithelial Caco-2 Cells

Authors: Lujuan Xing, Lijuan Fu, Yuejing Hao, Wangang Zhang

Journal: Antioxidants (Basel)

PubMed ID: 34572986

Doi: 10.3390/antiox10091354

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Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2

Authors: Jiajia Xie, Chengchao Ding, Jun He, Yuqing Zhang, Shuangshuang Ni, Xiangyu Zhang, Qingqing Chen, Jing Wang, Lina Huang, Hongliang He, Wenting Li, Huan Ma, Tengchuan Jin, Siping Zhang, Yong Gao

Journal: Front Immunol

PubMed ID: 34539645

Doi: 10.3389/fimmu.2021.715464

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Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

Authors: Avery J Lam, David T S Lin, Jana K Gillies, Prakruti Uday, Anne M Pesenacker, Michael S Kobor, Megan K Levings

Journal: Cell Rep

PubMed ID: 34348163

Doi: 10.1016/j.celrep.2021.109494

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Multiple G-quadruplexes in the LMNA promoter regulate LMNA variant 6 transcription and promote colon cancer cell growth

Authors: Tatsuya Nishikawa, Yuki Kuwano, Mayu Nakata, Kazuhito Rokutan, Kensei Nishida

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 34419630

Doi: 10.1016/j.bbagrm.2021.194746

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SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression

Authors: Stephanie Batalis, LeAnn C Rogers, Wayne O Hemphill, Christopher H Mauney, David A Ornelles, Thomas Hollis

Journal: Front Mol Biosci

PubMed ID: 34513928

Doi: 10.3389/fmolb.2021.724870

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