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3D culture system to study collective migration in mammary organoid epithelium

Authors: Yunzhe Lu, Ruolan Deng, Huanyang You, Pengfei Lu

Journal: STAR Protoc

PubMed ID: 34485944

Doi: 10.1016/j.xpro.2021.100778

Products & Services: Recombinant Proteins

Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease

Authors: Freja Herborg,Kathrine L. Jensen,Sasha Tolstoy,Natascha V. Arends,Leonie P. Posselt,Aparna Shekar, Jenny I Aguilar, Viktor K. Lund, Kevin Erreger,Mattias Rickhag,Matthew D. Lycas,Markus N. Lonsdale,Troels Rahbek-Clemmensen,Andreas T. Sørensen,Amy H. Newman,Annemette Løkkegaard,Ole Kjaerulff,Thomas Werge,Lisbeth B. Møller,Heinrich J.G. Matthies, Aurelio Galli, Lena E. Hjermind,6 and Ulrik Gether

Journal: JCI Insight

PubMed ID: 34375312

Doi: 10.1172/jci.insight.151496.

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro

Authors: Phong Quoc Nguyen , Christine Conesa , Elise Rabut , Gabriel Bragagnolo , Célia Gouzerh , Carlos Fernández-Tornero , Pascale Lesage , Juan Reguera and Jol Acker

Journal: Journal of Biological Chemistry

PubMed ID: 34416236

Doi: 10.1016/j.jbc.2021.101093

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Serological Testing for COVID-19, Immunological Surveillance, and Exploration of Protective Antibodies

Authors: Luis A Peroni, Jessica M Toscaro, Camila Canateli, Celisa C C Tonoli, Renata R de Olivera, Celso E Benedetti, Lais D Coimbra, Alexandre Borin Pereira, Rafael E Marques, José L Proença-Modena, Gabriel C Lima, Renata Viana, Jessica B Borges, Hui Tzu Lin-Wang, Cely S Abboud, Carlos Gun, Kleber G Franchini, Marcio C Bajgelman

Journal: Front Immunol

PubMed ID: 34489923

Doi: 10.3389/fimmu.2021.635701

Products & Services: Gene Synthesis

Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor

Authors: Daniel Parras, Patricia Solé, Thomas Delong, Pere Santamaría, Pau Serra

Journal: Front Immunol

PubMed ID: 34527002

Doi: 10.3389/fimmu.2021.737428

Products & Services: Peptide Synthesis

Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses

Authors: Bryan S Kaplan, Tavis K Anderson, Jennifer Chang, Jefferson Santos, Daniel Perez, Nicola Lewis, Amy L Vincent

Journal: J Virol

PubMed ID: 34379513

Doi: 10.1128/JVI.00632-21

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A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters

Authors: Mijia Lu, Yuexiu Zhang, Piyush Dravid, Anzhong Li, Cong Zeng, Mahesh Kc, Sheetal Trivedi, Himanshu Sharma, Supranee Chaiwatpongsakorn, Ashley Zani, Adam Kenney, Chuanxi Cai, Chengjin Ye, Xueya Liang, Jianming Qiu, Luis Martinez-Sobrido, Jacob S Yount, Prosper N Boyaka, Shan-Lu Liu, Mark E Peeples, Amit Kapoor, Jianrong Li

Journal: J Virol

PubMed ID: 34379509

Doi: 10.1128/JVI.00592-21

Products & Services: Gene Synthesis

Shrimp Plasma CREG Is a Hemocyte Activation Factor

Authors: Zhiqi Huang, Peng Yang, Fan Wang

Journal: Front Immunol.

PubMed ID: 34484206

Doi: 10.3389/fimmu.2021.707770

Products & Services: Polyclonal Antibody Services

The component of the mA writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors

Authors: Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H J Looijenga, Rui Henrique, Carmen Jerónimo

Journal: J Exp Clin Cancer Res

PubMed ID: 34446080

Doi: 10.1186/s13046-021-02072-9

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Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response

Authors: Laura M Fiori, Massimiliano Orri, Zahia Aouabed, Jean François Théroux, Rixing Lin, Corina Nagy, Benicio N Frey, Raymond W Lam, Glenda M MacQueen, Roumen Milev, Daniel J Müller, Sagar V Parikh, Susan Rotzinger, Rudolf Uher, Jane A Foster, Sidney H Kennedy, Gustavo Turecki

Journal: Transl Psychiatry

PubMed ID: 34420030

Doi: 10.1038/s41398-021-01564-8

Products & Services: Recombinant Proteins

Peptides derived from viral glycoprotein Gc Inhibit infection of severe fever with thrombocytopenia syndrome virus

Authors: Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing

Journal: Antiviral Res

PubMed ID: 34411654

Doi: 10.1016/j.antiviral.2021.105164

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of Local and Systemic Defence Responses by Flg22 Is Dependent on Daytime and Ethylene in Intact Tomato Plants

Authors: Zalán Czékus, András Kukri, Kamirán Áron Hamow, Gabriella Szalai, Irma Tari, Attila Ördög, Péter Poór

Journal: Int J Mol Sci

PubMed ID: 34361121

Doi: 10.3390/ijms22158354

Products & Services: Proteins, Expression, Isolation and Analysis

Performance evaluation of three automated quantitative immunoassays and their correlation with a surrogate virus neutralization test in coronavirus disease 19 patients and pre-pandemic controls

Authors: Kiwook Jung, Sue Shin, Minjeong Nam, Yun Ji Hong, Eun Youn Roh, Kyoung Un Park, Eun Young Song

Journal: J Clin Lab Anal

PubMed ID: 34369009

Doi: 10.1002/jcla.23921

Products & Services: Proteins, Expression, Isolation and Analysis

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

Authors: William Y Wang, Robert N Kent, Stephanie A Huang, Evan H Jarman, Eve H Shikanov, Christopher D Davidson, Harrison L Hiraki, Daphne Lin, Monica A Wall, Daniel L Matera, Jae-Won Shin, William J Polacheck, Ariella Shikanov, Brendon M Baker

Journal: Acta Biomater

PubMed ID: 34469789

Doi: 10.1016/j.actbio.2021.08.038

Products & Services: Proteins, Expression, Isolation and Analysis

Photoreactive hydrogel stiffness influences volumetric muscle loss repair

Authors: Ivan M Basurto, Juliana A Passipieri, Gregg M Gardner, Kathryn K Smith, Austin R Amacher, Audrey I Hansrisuk, George J Christ, Steven R Caliari

Journal: Tissue Eng Part A

PubMed ID: 34409861

Doi: 10.1089/ten.TEA.2021.0137

Products & Services: Proteins, Expression, Isolation and Analysis

PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model

Authors: Zhihong Sun, Ping Meng, Chunyu Su, Shengmin Ji, Yonglin Gao, Hongbo Wang, Jingwei Tian, Chunmei Li

Journal: Toxicol Appl Pharmacol

PubMed ID: 34428447

Doi: 10.1016/j.taap.2021.115698

Products & Services: Proteins, Expression, Isolation and Analysis

CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer

Authors: Yue Shi, Tao Han, Chong Liu

Journal: Ann Transl Med

PubMed ID: 34532373

Doi: 10.21037/atm-21-2934

Products & Services: Plasmid DNA Preparation

Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures

Authors: Erik Walinda, Daichi Morimoto, Tomoki Sorada, Kazuhiro Iwai, Kenji Sugase

Journal: Protein Expr Purif

PubMed ID: 34390872

Doi: 10.1016/j.pep.2021.105953

Products & Services: PCR Cloning and Subcloning

Tracing Clostridium perfringens strains from beef processing of slaughter house by pulsed-field gel electrophoresis, and the distribution and toxinotype of isolates in Shaanxi province, China

Authors: Yanfen Jiang, Yinghui Ma, Qianqian Liu, Tianmei Li, Yiming Li, Kangkang Guo, Yanming Zhang

Journal: Food Microbiol

PubMed ID: 34579847

Doi: 10.1016/j.fm.2021.103887

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N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

Authors: Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng

Journal: Elife

PubMed ID: 34414884

Doi: 10.7554/eLife.69091

Products & Services: Mutant Libraries

The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end

Authors: Dalibor Kosek, Ivana Grabundzija, Haotian Lei, Ilija Bilic, Huaibin Wang, Yukun Jin, Graham F Peaslee, Alison B Hickman, Fred Dyda

Journal: Mol Cell

PubMed ID: 34403695

Doi: 10.1016/j.molcel.2021.07.028

Products & Services: Mutant Libraries

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Authors: Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan

Journal: Viruses

PubMed ID: 34452398

Doi: 10.3390/v13081533

Products & Services: Mutagenesis Services

Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett's esophagus

Authors: Nandan P Deshpande, Stephen M Riordan, Claire J Gorman, Shaun Nielsen, Tonia L Russell, Carolina Correa-Ospina, Bentotage S M Fernando, Shafagh A Waters, Natalia Castaño-Rodríguez, Si Ming Man, Nicodemus Tedla, Marc R Wilkins, Nadeem O Kaakoush

Journal: Genome Med

PubMed ID: 34412659

Doi: 10.1186/s13073-021-00951-6

Products & Services: Monoclonal Antibody Services

Dry-Cured Ham-Derived Peptide (Asp-Leu-Glu-Glu) Exerts Cytoprotective Capacity in Human Intestinal Epithelial Caco-2 Cells

Authors: Lujuan Xing, Lijuan Fu, Yuejing Hao, Wangang Zhang

Journal: Antioxidants (Basel)

PubMed ID: 34572986

Doi: 10.3390/antiox10091354

Products & Services: Molecular Biology Reagents

Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2

Authors: Jiajia Xie, Chengchao Ding, Jun He, Yuqing Zhang, Shuangshuang Ni, Xiangyu Zhang, Qingqing Chen, Jing Wang, Lina Huang, Hongliang He, Wenting Li, Huan Ma, Tengchuan Jin, Siping Zhang, Yong Gao

Journal: Front Immunol

PubMed ID: 34539645

Doi: 10.3389/fimmu.2021.715464

Products & Services: Mammalian Expression

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

Authors: Avery J Lam, David T S Lin, Jana K Gillies, Prakruti Uday, Anne M Pesenacker, Michael S Kobor, Megan K Levings

Journal: Cell Rep

PubMed ID: 34348163

Doi: 10.1016/j.celrep.2021.109494

Products & Services: GenParts™ DNA Fragments

Multiple G-quadruplexes in the LMNA promoter regulate LMNA variant 6 transcription and promote colon cancer cell growth

Authors: Tatsuya Nishikawa, Yuki Kuwano, Mayu Nakata, Kazuhito Rokutan, Kensei Nishida

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 34419630

Doi: 10.1016/j.bbagrm.2021.194746

Products & Services: Gene Synthesis

SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression

Authors: Stephanie Batalis, LeAnn C Rogers, Wayne O Hemphill, Christopher H Mauney, David A Ornelles, Thomas Hollis

Journal: Front Mol Biosci

PubMed ID: 34513928

Doi: 10.3389/fmolb.2021.724870

Products & Services: DNA Sequencing

Vanillic acid and methoxyhydroquinone production from guaiacyl units and related aromatic compounds using Aspergillus niger cell factories

Authors: Ronnie J M Lubbers, Adiphol Dilokpimol, Paula A Nousiainen, Răzvan C Cioc, Jaap Visser, Pieter C A Bruijnincx, Ronald P de Vries

Journal: Microb Cell Fact

PubMed ID: 34344380

Doi: 10.1186/s12934-021-01643-x

Products & Services: DNA Sequencing

Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma

Authors: Xu Chen, Jing Yang, Hailan Shen, Xuemei Zhang, Hong Wang, Guangying Wu, Yuhong Qi, Ling Wang, Wenchun Xu

Journal: J Asthma Allergy

PubMed ID: 34421304

Doi: 10.2147/JAA.S316250

Products & Services: DNA Sequencing

At sixes and sevens: cryptic domain in the metal binding chain of the human copper transporter ATP7A

Authors: Eva-Maria E Uhlemann, Woonghee Lee, Marco Tonelli, Oleg Y Dmitriev

Journal: Biophys J

PubMed ID: 34461106

Doi: 10.1016/j.bpj.2021.08.029

Products & Services: DNA Sequencing

Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease

Authors: Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Bao Zhang, Yaoqi Zhou, Jian Zhan, Wei Xu

Journal: Int J Biol Macromol

PubMed ID: 34364941

Doi: 10.1016/j.ijbiomac.2021.07.184

Products & Services: DNA Sequencing

Authors: Kamila R Santos, Fernando N Souza, Eduardo M Ramos-Sanchez, Camila F Batista, Luiza C Reis, Wesley F Fotoran, Marcos B Heinemann, Hiro Goto, Magnus Gidlund, Adriano F Cunha, Angélica Rosa Faria, Hélida M Andrade, Andrey P Lage, Mônica M O P Cerqueira, Alice M M P Della Libera

Journal: Vaccines (Basel)

PubMed ID: 34452024

Doi: 10.3390/vaccines9080899

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Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

Authors: Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour, Farah Bokharaei-Salim

Journal: BMC Cancer

PubMed ID: 34399719

Doi: 10.1186/s12885-021-08658-y

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Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects

Authors: Yajuan Li, Yaohua Zhang, Qingsong Hu, Sergey D Egranov, Zhen Xing, Zhao Zhang, Ke Liang, Youqiong Ye, Yinghong Pan, Sujash S Chatterjee, Brandon Mistretta, Tina K Nguyen, David H Hawke, Preethi H Gunaratne, Mien-Chie Hung, Leng Han, Liuqing Yang, Chunru Lin

Journal: Genome Med

PubMed ID: 34454586

Doi: 10.1186/s13073-021-00937-4

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CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays

Authors: Karl W Barber, Ellen Shrock, Stephen J Elledge

Journal: Mol Cell

PubMed ID: 34390675

Doi: 10.1016/j.molcel.2021.07.027

Products & Services: Custom DNA/RNA Oligos

Biochemical properties of CumA multicopper oxidase from plant pathogen, Pseudomonas syringae

Authors: Konan Ishida, Yuya Tsukamoto, Masaki Horitani, Tomohisa Ogawa, Yoshikazu Tanaka

Journal: Biosci Biotechnol Biochem

PubMed ID: 34244699

Doi: 10.1093/bbb/zbab123

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The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing

Authors: Andrew Tsatsanis, Andrew N McCorkindale, Bruce X Wong, Ellis Patrick, Tim M Ryan, Robert W Evans, Ashley I Bush, Greg T Sutherland, Asipu Sivaprasadarao, Boris Guennewig, James A Duce

Journal: Mol Psychiatry

PubMed ID: 34400772

Doi: 10.1038/s41380-021-01248-1

Products & Services: Catalog Peptides

Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR

Authors: Kyoko Furuita, Marina Hiraoka, Kentaro Hanada, Toshimichi Fujiwara, Chojiro Kojima

Journal: FEBS Lett

PubMed ID: 34312846

Doi: 10.1002/1873-3468.14166

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A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

Authors: Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriyama, Akihiko Sato, Takao Nomura, Shuhei Sakakibara, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku, Kohei Yumoto, Cong Tian, Hideo Fukuhara, Michihito Sasaki, Yasuko Orba, Nozomi Shiwa, Naoko Iwata, Noriyo Nagata, Tateki Suzuki, Jiei Sasaki, Tsuyoshi Sekizuka, Keisuke Tonouchi, Lin Sun, Shuetsu Fukushi, Hiroyuki Satofuka, Yasuhiro Kazuki, Mitsuo Oshimura, Tomohiro Kurosaki, Makoto Kuroda, Yoshiharu Matsuura, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Katsumi Maenaka, Yoshimasa Takahashi

Journal: Immunity

PubMed ID: 34508662

Doi: 10.1016/j.immuni.2021.08.025

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Structural insights into how Prp5 proofreads the pre-mRNA branch site

Authors: Zhenwei Zhang, Norbert Rigo, Olexandr Dybkov, Jean-Baptiste Fourmann, Cindy L Will, Vinay Kumar, Henning Urlaub, Holger Stark, Reinhard Lührmann

Journal: Nature

PubMed ID: 34349264

Doi: 10.1038/s41586-021-03789-5

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Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies

Authors: Inna Sekirov, Martin Petric, Erin Carruthers, David Lawrence, Tamara Pidduck, Jesse Kustra, Jonathan Laley, Min-Kuang Lee, Navdeep Chahil, Annie Mak, Paul N Levett, Emelissa Mendoza, Heidi Wood, Mike Drebot, Mel Krajden, Muhammad Morshed

Journal: Access Microbiol

PubMed ID: 34888485

Doi: 10.1099/acmi.0.000257

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Biosynthesis of silver nanoparticles with antimicrobial and anticancer properties using two novel yeasts

Authors: Xin Liu, Jia-Le Chen, Wen-Yu Yang, Yu-Cheng Qian, Jing-Yu Pan, Chen-Nianci Zhu, Li Liu, Wen-Bin Ou, Hong-Xin Zhao, Dian-Peng Zhang

Journal: Sci Rep

PubMed ID: 34349183

Doi: 10.1038/s41598-021-95262-6

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Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression

Authors: Ling Zhang, Lei Zhang, Rubo Sui

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34421302

Doi: 10.2147/NDT.S317207

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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease

Authors: Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L Bunting, Sarah G Aldous, Antonio Porro, José R Vicente, Nicholas D Allen, Hilary Wilkinson, Gillian P Bates, Alessandro A Sartori, Konstantinos Thalassinos, Gabriel Balmus, Sarah J Tabrizi

Journal: Cell Rep

PubMed ID: 34469738

Doi: 10.1016/j.celrep.2021.109649

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Single-cell imaging of T cell immunotherapy responses in vivo

Authors: Chuan Yan, Qiqi Yang, Songfa Zhang, David G Millar, Eric J Alpert, Daniel Do, Alexandra Veloso, Dalton C Brunson, Benjamin J Drapkin, Marcello Stanzione, Irene Scarfò, John C Moore, Sowmya Iyer, Qian Qin, Yun Wei, Karin M McCarthy, John F Rawls, Nick J Dyson, Mark Cobbold, Marcela V Maus, David M Langenau

Journal: J Exp Med

PubMed ID: 34415995

Doi: 10.1084/jem.20210314

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Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications

Authors: Akvile Haeckel, Lena Ascher, Nicola Beindorff, Sonal Prasad, Karolina Garczyńska, Jing Guo, Eyk Schellenberger

Journal: Apoptosis

PubMed ID: 34405304

Doi: 10.1007/s10495-021-01686-w

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Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor

Authors: Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikolaj Slabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J M Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell

Journal: Cancer Discov

PubMed ID: 34429321

Doi: 10.1158/2159-8290.CD-21-0560

Products & Services: Proteins, Expression, Isolation and Analysis

Hsp40s play complementary roles in the prevention of tau amyloid formation

Authors: Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzweig

Journal: Elife

PubMed ID: 34369377

Doi: 10.7554/eLife.69601

Products & Services: Proteins, Expression, Isolation and Analysis

Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge

Authors: Teresa E Sorvillo, Robert W Cross, Dylan M Johnson, Natalie S Dobias, Karla A Fenton, Chad E Mire, Thomas W Geisbert

Journal: npj Vaccines

PubMed ID: 34373461

Doi: 10.1038/s41541-021-00361-0

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An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

Authors: Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A Polyzos, Andrew D Chen, Michael C Martin, Edward S Barnard, James B Brown, Cynthia T McMurray

Journal: Sci Rep

PubMed ID: 34341363

Doi: 10.1038/s41598-021-93686-8

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Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies

Authors: Yan Lou, Wenxiang Zhao, Haitao Wei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, Ping Wang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du, Tingbo Liang, Yunqing Qiu, Mingyao Liu

Journal: Biotechnol J

PubMed ID: 34379353

Doi: 10.1002/biot.202100207

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

Authors: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

Journal: Elife

PubMed ID: 34435951

Doi: 10.7554/eLife.68843

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Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10

Authors: Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan

Journal: J Biol Chem

PubMed ID: 34478713

Doi: 10.1016/j.jbc.2021.101141

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The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy

Authors: Shayne E Quinn, Lu Huang, Jason G Kerkvliet, Joel A Swanson, Steve Smith, Adam D Hoppe, Robert B Anderson, Natalie W Thiex, Brandon L Scott

Journal: Nat Commun

PubMed ID: 34376698

Doi: 10.1038/s41467-021-25187-1

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Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production

Authors: Sujata Senapati, Ross J Darling, Kathleen A Ross, Michael J Wannemeuhler, Balaji Narasimhan, Surya K Mallapragada

Journal: Sci Adv

PubMed ID: 34348905

Doi: 10.1126/sciadv.abj1691

Products & Services: Proteins, Expression, Isolation and Analysis

Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy

Authors: Jessica S Fortin, Ashley A Hetak, Kelsey E Duggan, Caroline M Burglass, Hailey B Penticoff, Harold C Schott

Journal: Sci Rep

PubMed ID: 34362943

Doi: 10.1038/s41598-021-95396-7

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Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

Authors: Kyunghun Min, Thomas F Jannace, Haoyu Si, Krishna R Veeramah, John D Haley, James B Konopka

Journal: PLoS Pathog

PubMed ID: 34398936

Doi: 10.1371/journal.ppat.1009861

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Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice

Authors: Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W Ian Lipkin, David M Knipe, Eurico Arruda, Sean P J Whelan

Journal: MBio

PubMed ID: 34340542

Doi: 10.1128/mBio.00463-21

Products & Services: Mammalian Expression

The Role of Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast

Authors: Piotr Hapeta, Patrycja Szczepańska, Tadeusz Witkowski, Jean-Marc Nicaud, Anne-Marie Crutz-Le Coq, Zbigniew Lazar

Journal: Int J Mol Sci

PubMed ID: 34502217

Doi: 10.3390/ijms22179282

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Secondary Structure of Human Evolved Gene Product NCYM Analyzed by Vacuum-Ultraviolet Circular Dichroism

Authors: Tatsuhito Matsuo, Kazuma Nakatani, Taiki Setoguchi, Koichi Matsuo, Taro Tamada, Yusuke Suenaga

Journal: Front Oncol

PubMed ID: 34497756

Doi: 10.3389/fonc.2021.688852

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Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers

Authors: Khuraijam Dhanachandra Singh, Zaira P Jara, Terri Harford, Prasenjit Prasad Saha, Triveni R Pardhi, Russell Desnoyer, Sadashiva S Karnik

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34380734

Doi: 10.1073/pnas.2019126118

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Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

Authors: Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D Tolbert, Michael W Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes

Journal: biorxiv

PubMed ID: 34373853

Doi: 10.1101/2021.08.02.454546

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CRISPR-Cas9-mediated reactivation of the uricase pseudogene in human cells prevents acute hyperuricemia

Authors: Lais de Lima Balico, Eric A Gaucher

Journal: Mol Ther Nucleic Acids

PubMed ID: 34589279

Doi: 10.1016/j.omtn.2021.08.002

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Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

Authors: Megan C Mladinich, Jonas N Conde, William R Schutt, Sook-Young Sohn, Erich R Mackow

Journal: MBio

PubMed ID: 34399621

Doi: 10.1128/mBio.01962-21

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

Authors: Dimitris C Kanellis, Jaime A Espinoza, Asimina Zisi, Elpidoforos Sakkas, Jirina Bartkova, Anna-Maria Katsori, Johan Boström, Lars Dyrskjøt, Helle Broholm, Mikael Altun, Simon J Elsässer, Mikael S Lindström, Jiri Bartek

Journal: Sci Adv

PubMed ID: 34348895

Doi: 10.1126/sciadv.abf7561

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Multiple epitopes of hepatitis B virus surface antigen targeted by human plasma-derived immunoglobulins coincide with clinically observed escape mutations

Authors: Sreya Tarafdar, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Lu Deng, Yanqun Xu, Yong He, Evi Struble, Pei Zhang

Journal: J Med Virol

PubMed ID: 34406663

Doi: 10.1002/jmv.27278

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Complete and efficient conversion of plant cell wall hemicellulose into high-value bioproducts by engineered yeast

Authors: Liang Sun, Jae Won Lee, Sangdo Yook, Stephan Lane, Ziqiao Sun, Soo Rin Kim, Yong-Su Jin

Journal: Nat Commun

PubMed ID: 34404791

Doi: 10.1038/s41467-021-25241-y

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The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

Authors: Huafeng Lin, Gang Li, Xiangwen Peng, Aimin Deng, Lei Ye, Lei Shi, Tuanmei Wang, Jun He

Journal: Front Cell Infect Microbiol

PubMed ID: 34513721

Doi: 10.3389/fcimb.2021.590989

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Authors: Vasiliki Courelli, Alla Ahmad, Majid Ghassemian, Chris Pruitt, Paul J Mills, Geert W Schmid-Schönbein

Journal: Cell Mol Bioeng

PubMed ID: 34900012

Doi: 10.1007/s12195-021-00693-w

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Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L

Authors: Mona Raeispour Shirazi, Sara Alsadat Rahpeyma, Sajad Rashidi Monfared, Jafar Zolala, Azadeh Lohrasbi-Nejad

Journal: PLoS ONE

PubMed ID: 34449796

Doi: 10.1371/journal.pone.0256704

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Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19

Authors: Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, Berenice Calderón-Pérez, Miriam Pérez-Saldívar, Karla Acosta-Virgen, Hugo González-Conchillos, Brenda Vargas-Hernández, Ana Olivares-Martínez, Roberto Ruiz-Medrano, Daniela Roa-Velázquez, Edgar Morales-Ríos, Jorge Ramos-Flores, Gustavo Torres-Franco, Diana Peláez-González, Jorge Fernández-Hernández, Martha Espinosa-Cantellano, Diana Tapia-Sidas, José Abrahan Ramírez-Pool, América Padilla-Viveros, Beatriz Xoconostle-Cázares

Journal: Vaccines (Basel)

PubMed ID: 34452053

Doi: 10.3390/vaccines9080928

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Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

Authors: Suhas Sureshchandra, Michael Z Zulu, Brianna Doratt, Allen Jankeel, Delia Tifrea, Robert Edwards, Monica Rincon, Nicole E Marshall, Ilhem Messaoudi

Journal: biorxiv

PubMed ID: 34462741

Doi: 10.1101/2021.08.23.457408

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Simultaneous Multiplex Genome Engineering Accelerated Natural Transformation in

Authors: Aihua Deng, Zhaopeng Sun, Tiantian Wang, Di Cui, Lai Li, Shuwen Liu, Fei Huang, Tingyi Wen

Journal: Front Microbiol

PubMed ID: 34484154

Doi: 10.3389/fmicb.2021.714449

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Comparative phylogenetic analysis of CBL reveals the gene family evolution and functional divergence in Saccharum spontaneum

Authors: Xiaomin Feng, Yongjun Wang, Nannan Zhang, Shuai Gao, Jiayun Wu, Rui Liu, Yonghong Huang, Jisen Zhang, Yongwen Qi

Journal: BMC Plant Biol

PubMed ID: 34425748

Doi: 10.1186/s12870-021-03175-3

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Characterization of murine cytomegalovirus infection and induction of calcification in Murine Aortic Vascular Smooth Muscle Cells (MOVAS)

Authors: Cassandra M Bonavita, Timothy M White, Brent A Stanfield, Rhonda D Cardin

Journal: J Virol Methods

PubMed ID: 34461152

Doi: 10.1016/j.jviromet.2021.114270

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Nontypeable P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance

Authors: Oskar Thofte, Serena Bettoni, Yu-Ching Su, John Thegerström, Sandra Jonsson, Emma Mattsson, Linda Sandblad, Sara Martí, Junkal Garmendia, Anna M Blom, Kristian Riesbeck

Journal: J Immunol

PubMed ID: 34433620

Doi: 10.4049/jimmunol.2100105

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An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

Authors: Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen, Xianlei Li, Qiankun Ni, Yuan Yuan, Yaling Gan, Junge Chen, Fangzhou Li, Jinchao Zhang, Caiwen Ou, Yongxiang Zhao, Xiaoxuan Liu, Xing-Jie Liang

Journal: Nat Commun

PubMed ID: 34400628

Doi: 10.1038/s41467-021-25197-z

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A chimeric virus-based probe unambiguously detects live circulating tumor cells with high specificity and sensitivity

Authors: Xinping Fu, Lihua Tao, Xiaoliu Zhang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34631928

Doi: 10.1016/j.omtm.2021.08.007

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Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

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A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S

Authors: Xiankun Wang, Yuchun Zhao , Yaojie Gao , Xiangkun Luo , Aiqin Du , Zixin Deng , T. Mark Zabriskied , Xinyi Hea, and Ming Jiang

Journal: PNAS

PubMed ID: 34282016

Doi: 10.1073/pnas.2102318118

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Chemerin/ChemR23 signaling mediates the effects of ultra-high molecular weight polyethylene wear particles on the balance between osteoblast and osteoclast differentiation

Authors: Fengchao Zhao, Dingwei Cang, Jianzhi Zhang, Li Zheng

Journal: Ann Transl Med

PubMed ID: 34430590

Doi: 10.21037/atm-21-2945

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Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations

Authors: Konlavat Siriwattananon, Suwimon Manopwisedjaroen, Balamurugan Shanmugaraj, Eakachai Prompetchara, Chutitorn Ketloy, Supranee Buranapraditkun, Kittipan Tharakhet, Papatsara Kaewpang, Kiat Ruxrungtham, Arunee Thitithanyanont, Waranyoo Phoolcharoen

Journal: Vaccines (Basel)

PubMed ID: 34358160

Doi: 10.3390/vaccines9070744

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Lipopolysaccharide Binding Protein and CD14, Cofactors of Toll-like Receptors, Are Essential for Low-Grade Inflammation-Induced Exacerbation of Cartilage Damage in Mouse Models of Posttraumatic Osteoarthritis

Authors: Yoonkyung Won, Jeong-In Yang, Seulki Park, Jang-Soo Chun

Journal: Arthritis Rheumatol

PubMed ID: 33559324

Doi: 10.1002/art.41679

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Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

Authors: Mengyao Mu, Hongjing Zhao, Yu Wang, Menghao Guo, Xiaopan Nie, Yachen Liu, Mingwei Xing

Journal: Dev Comp Immunol

PubMed ID: 34329648

Doi: 10.1016/j.dci.2021.104211

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RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors

Authors: Megumi Shigematsu, Takuya Kawamura, Keisuke Morichika, Natsuko Izumi, Takashi Kiuchi, Shozo Honda, Venetia Pliatsika, Ryuma Matsubara, Isidore Rigoutsos, Susumu Katsuma, Yukihide Tomari, Yohei Kirino

Journal: Nat Commun

PubMed ID: 34301931

Doi: 10.1038/s41467-021-24681-w

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Cryo-EM structure of human Wntless in complex with Wnt3a

Authors: Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma

Journal: Nat Commun

PubMed ID: 34315898

Doi: 10.1038/s41467-021-24731-3

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Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Authors: Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang

Journal: Nat Commun

PubMed ID: 34244522

Doi: 10.1038/s41467-021-24514-w

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Contributions of S- and R-citalopram to the citalopram-induced modulation of the function of Nav15 voltage-gated sodium channels

Authors: Yoshihiko Nakatani, Taku Amano

Journal: Eur J Pharmacol

PubMed ID: 34280395

Doi: 10.1016/j.ejphar.2021.174316

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Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7-Expressing Carcinoma in the Cervicovaginal Tract

Authors: Talia R Henkle, Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Louise Ferrall, Deyin Xing, Chien-Fu Hung, T-C Wu

Journal: Cancer Res

PubMed ID: 34215618

Doi: 10.1158/0008-5472.CAN-21-0399

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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

Authors: Ahmad Jomaa, Simon Eitzinger, Zikun Zhu, Sowmya Chandrasekar, Kan Kobayashi, Shu-Ou Shan, Nenad Ban

Journal: Cell Rep

PubMed ID: 34260909

Doi: 10.1016/j.celrep.2021.109350

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A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

Authors: Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Journal: J Mol Biol

PubMed ID: 34302818

Doi: 10.1016/j.jmb.2021.167174

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The expansion of activated naive DNA autoreactive B cells and its association with disease activity in systemic lupus erythematosus patients

Authors: Kittikorn Wangriatisak, Chokchai Thanadetsuntorn, Thamonwan Krittayapoositpot, Chaniya Leepiyasakulchai, Thanitta Suangtamai, Pintip Ngamjanyaporn, Ladawan Khowawisetsut, Prasong Khaenam, Chavachol Setthaudom, Prapaporn Pisitkun, Patchanee Chootong

Journal: Arthritis Res Ther

PubMed ID: 34229724

Doi: 10.1186/s13075-021-02557-0

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Authors: Monique S Straub, Carolina Alvadia, Marta Sawicka, Raimund Dutzler

Journal: Elife

PubMed ID: 34263724

Doi: 10.7554/eLife.69800

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Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling

Authors: Hannes Merten, Fabian Brandl, Martina Zimmermann, Jonas V Schaefer, Linda Irpinio, Kine M K Sand, Jeannette Nilsen, Jan Terje Andersen, Uwe Zangemeister-Wittke, Andreas Plückthun

Journal: Eur J Pharm Biopharm

PubMed ID: 34303832

Doi: 10.1016/j.ejpb.2021.07.011

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

Authors: Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D Kwong

Journal: Nat Commun

PubMed ID: 34244481

Doi: 10.1038/s41467-021-24291-6

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MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin

Authors: Ji-Young Yoo, Margaret Yeh, Yin-Ying Wang, Christina Oh, Zhong-Ming Zhao, Balveen Kaur, Tae-Jin Lee

Journal: Biomedicines

PubMed ID: 34356844

Doi: 10.3390/biomedicines9070780

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Decline in neutralising antibody responses, but sustained T-cell immunity, in COVID-19 patients at 7 months post-infection

Authors: Jun Chen, Xiaomin Liu, Xinyu Zhang, Yixiao Lin, Danping Liu, Jingna Xun, Zhenyan Wang, Ling Gu, Qian Li, Dan Yin, Junyang Yang, Hongzhou Lu

Journal: Clin Transl Immunology

PubMed ID: 34336207

Doi: 10.1002/cti2.1319

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Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

Authors: Lisa R Volpatti, Rachel P Wallace, Shijie Cao, Michal M Raczy, Ruyi Wang, Laura T Gray, Aaron T Alpar, Priscilla S Briquez, Nikolaos Mitrousis, Tiffany M Marchell, Maria Stella Sasso, Mindy Nguyen, Aslan Mansurov, Erica Budina, Ani Solanki, Elyse A Watkins, Mathew R Schnorenberg, Andrew C Tremain, Joseph W Reda, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Shann S Yu, Balaji Manicassamy, James L LaBelle, Matthew V Tirrell, Glenn Randall, Marcin Kwissa, Melody A Swartz, Jeffrey A Hubbell

Journal: ACS Cent Sci

PubMed ID: 34466656

Doi: 10.1021/acscentsci.1c00596

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Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients

Authors: René Schramm, Angelika Costard-Jäckle, Rasmus Rivinius, Bastian Fischer, Benjamin Müller, Udo Boeken, Assad Haneya, Zdenek Provaznik, Cornelius Knabbe, Jan Gummert

Journal: Clin Res Cardiol

PubMed ID: 34241676

Doi: 10.1007/s00392-021-01880-5

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