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Increased SERPINA3 Level Is Associated with Ulcerative Colitis

Authors: Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen

Journal: Diagnostics (Basel)

PubMed ID: 34943607

Doi: 10.3390/diagnostics11122371

Products & Services: Recombinant Proteins

Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

Authors: Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, and Moutih Rafe

Journal: Cell Reports Medicine

PubMed ID: 35028603

Doi: 10.1016/j.xcrm.2021.100455

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An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility

Authors: Abhishek Das, Satarupa Dutta, Dewanshu Sharma, Amit Pal, Nirmalya Ganguli, Subeer S Majumdar

Journal: Bioengineered

PubMed ID: 34436976

Doi: 10.1080/21655979.2021.1955509

Products & Services: PCR Cloning and Subcloning

Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM

Authors: Fuji Lai, Huiqin Zhang, Binbin Xu, Yangyang Xie, Hua Yu

Journal: Bioengineered

PubMed ID: 34506209

Doi: 10.1080/21655979.2021.1958558

Products & Services: Molecular Biology Reagents

Study protocol for a randomised clinical trial of a decision aid and values clarification method for parents of a fetus or neonate diagnosed with a life-threatening congenital heart defect

Authors: Rebecca K Delaney, Nelangi M Pinto, Elissa M Ozanne, Louisa A Stark, Mandy L Pershing, Alistair Thorpe, Holly O Witteman, Praveen Thokala, Linda M Lambert, Lisa M Hansen, Tom H Greene, Angela Fagerlin

Journal: BMJ Open

PubMed ID: 34893487

Doi: 10.1136/bmjopen-2021-055455

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Analysis of Immunoreactivity of α/α-Tropomyosin from , Based on IgE Epitopes and Structural Characteristics

Authors: Nai-Ru Ji, Xin-Yu Han, Chen-Chen Yu, Yu-Jia Wang, Xin-Rong He, Hong Liu, Fei Huan, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: J Agric Food Chem

PubMed ID: 34881872

Doi: 10.1021/acs.jafc.1c06401

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Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity

Authors: Meng-Meng Chen, Si-Ru Yang, Jian Wang, Ya-Li Fang, You-Liang Peng, Jun Fan

Journal: J Exp Bot

PubMed ID: 34864987

Doi: 10.1093/jxb/erab530

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In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion

Authors: Xiaocui Li, Min An, Zhenjun Gao

Journal: J Oncol

PubMed ID: 34899909

Doi: 10.1155/2021/7430468

Products & Services: Protein and Antibody Isolation

Lysine β-Hydroxybutyrylation Improves Stability of COVID-19 Antibody

Authors: Zihua Li, Yudian Zhang, Meng Han, Haiteng Deng, Fuqing Wu, Gang Liu, Guo-Qiang Chen

Journal: Biomacromolecules

PubMed ID: 34879647

Doi: 10.1021/acs.biomac.1c01435

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Novel carotenogenic gene combinations from red yeasts enhanced lycopene and beta-carotene production in Saccharomyces cerevisiae from the low-cost substrate sucrose

Authors: Akaraphol Watcharawipas, Kitisak Sansatchanon, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Weerawat Runguphan, Kanokarn Kocharin

Journal: FEMS Yeast Res

PubMed ID: 34865010

Doi: 10.1093/femsyr/foab062

Products & Services: Gene Synthesis

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy

Authors: Hassan Issafras, Shilong Fan, Chi-Ling Tseng, Yunchih Cheng, Peihua Lin, Lisa Xiao, Yun-Ju Huang, Chih-Hsiang Tu, Ya-Chin Hsiao, Min Li, Yen-Hsiao Chen, Chien-Hsin Ho, Ou Li, Yanling Wang, Sandra Chen, Zhenyu Ji, Eric Zhang, Yi-Ting Mao, Eugene Liu, Shumin Yang, Weidong Jiang

Journal: PLoS ONE

PubMed ID: 34972111

Doi: 10.1371/journal.pone.0257972

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Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

Authors: Kimberly Nellenbach, Alexander Kyu, Nina Guzzetta, Ashley C Brown

Journal: Blood Adv

PubMed ID: 34555851

Doi: 10.1182/bloodadvances.2021004417

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Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression

Authors: Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng, Heng Song, Xiang Zhou

Journal: Nucleic Acids Res

PubMed ID: 34850126

Doi: 10.1093/nar/gkab1124

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Engineering Ligand and Receptor Pairs with LIPSTIC to Track Cell-Cell Interactions

Authors: Dafne Alberti, Michelle Guarniero, Agnieszka K Maciola, Enrico Dotta, Giulia Pasqual

Journal: Curr Protoc

PubMed ID: 34870906

Doi: 10.1002/cpz1.311

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SARS-CoV-2 vaccine in patients with systemic sclerosis: Impact of disease subtype and therapy

Authors: Percival Degrava Sampaio-Barros, Ana Cristina Medeiros-Ribeiro, Ana Paula Luppino-Assad, Renata Miossi, Henrique Carriço da Silva, Emily F V N Yuki, Sandra G Pasoto, Carla G S Saad, Clóvis A Silva, Léonard V K Kupa, Giordano B H Deveza, Tatiana N Pedrosa, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34894235

Doi: 10.1093/rheumatology/keab886

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Authors:

Journal: Lancet Infect Dis

PubMed ID: 34953520

Doi: 10.1016/S1473-3099(21)00751-9

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Cryptic splicing events result in unexpected protein products from calpain-10 (CAPN10) cDNA

Authors: Yasuko Ono, Naoko Doi, Mayumi Shindo, Pablo Pánico, Ana María Salazar

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 34906616

Doi: 10.1016/j.bbamcr.2021.119188

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Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

Authors: Jennifer West, Sandeep Satapathy, Daniel R Whiten, Megan Kelly, Nicholas J Geraghty, Emma-Jayne Proctor, Pietro Sormanni, Michele Vendruscolo, Joel N Buxbaum, Marie Ranson, Mark R Wilson

Journal: Sci Adv

PubMed ID: 34890220

Doi: 10.1126/sciadv.abf7606

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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Authors: Emma L Lewis, Rong Xu, Jean-Christophe Beltra, Shin Foong Ngiow, Jordana Cohen, Rahul Telange, Alexander Crane, Deirdre Sawinski, E John Wherry, Paige M Porrett

Journal: J Exp Med

PubMed ID: 34882194

Doi: 10.1084/jem.20201599

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The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction

Authors: Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang, Jianghua Zhong

Journal: Bioengineered

PubMed ID: 34506248

Doi: 10.1080/21655979.2021.1964894

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Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

Authors: Luke F Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S Jardetzky

Journal: Nat Commun

PubMed ID: 34862384

Doi: 10.1038/s41467-021-27397-z

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MON-2, a Golgi protein, mediates autophagy-dependent longevity in

Authors: Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom, Ara B Hwang, Dae-Eun Jeong, Özlem Altintas, Keunhee Seo, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Yujin Lee, Jooyeon Sohn, Eun Ji E Kim, Sungeun Ju, Seong Kyu Han, Hyun-Jun Nam, Linnea Adams, Youngjae Ryu, Dong Jin Moon, Chanhee Kang, Joo-Yeon Yoo, Sang Ki Park, Chang Man Ha, Malene Hansen, Sanguk Kim, Cheolju Lee, Seung-Yeol Park, Seung-Jae V Lee

Journal: Sci Adv

PubMed ID: 34860542

Doi: 10.1126/sciadv.abj8156

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MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

Authors: Martin Houlard, Erin E Cutts, Muhammad S Shamim, Jonathan Godwin, David Weisz, Aviva Presser Aiden, Erez Lieberman-Aiden, Lothar Schermelleh, Kim Nasmyth, Alessandro Vannini

Journal: Elife

PubMed ID: 34850681

Doi: 10.7554/eLife.73348

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Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway

Authors: Kelan Yuan, Jiao Zheng, Xiao Shen, Yaying Wu, Yu Han, Xiuming Jin, Xiaodan Huang

Journal: Int Immunopharmacol

PubMed ID: 34906854

Doi: 10.1016/j.intimp.2021.108426

Products & Services: Protein and Antibody Isolation

Impact of Molecular Modifications on the Immunogenicity and Efficacy of Recombinant Raccoon Poxvirus-Vectored Rabies Vaccine Candidates in Mice

Authors: Carly M Malavé, Jaime Lopera-Madrid, Lex G Medina-Magües, Tonie E Rocke, Jorge E Osorio

Journal: Vaccines (Basel)

PubMed ID: 34960182

Doi: 10.3390/vaccines9121436

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Synthesis of Human Bone Morphogenetic Protein-2 (hBMP-2) in Periplasmic Space: Its Characterization and Preclinical Testing

Authors: João E Oliveira, Miriam F Suzuki, Renata Damiani, Eliana R Lima, Kleicy C Amaral, Anderson M S Santos, Geraldo S Magalhães, Leonardo P Faverani, Luís A V D Pereira, Paolo Bartolini

Journal: Cells

PubMed ID: 34944033

Doi: 10.3390/cells10123525

Products & Services: Protein and Antibody Isolation

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

Authors: Sisi Shan, Chee Keng Mok, Shuyuan Zhang, Jun Lan, Jizhou Li, Ziqing Yang, Ruoke Wang, Lin Cheng, Mengqi Fang, Zhen Qin Aw, Jinfang Yu, Qi Zhang, Xuanling Shi, Tong Zhang, Zheng Zhang, Jianbin Wang, Xinquan Wang, Justin Jang Hann Chu, Linqi Zhang

Journal: Front Immunol

PubMed ID: 34966387

Doi: 10.3389/fimmu.2021.766821

Products & Services: Mammalian Expression

Engineering CAR-T cells to activate small-molecule drugs in situ

Authors: Thomas J Gardner, J Peter Lee, Christopher M Bourne, Dinali Wijewarnasuriya, Nihar Kinarivala, Keifer G Kurtz, Broderick C Corless, Megan M Dacek, Aaron Y Chang, George Mo, Kha M Nguyen, Renier J Brentjens, Derek S Tan, David A Scheinberg

Journal: Nat Chem Biol

PubMed ID: 34969970

Doi: 10.1038/s41589-021-00932-1

Products & Services: Protein and Antibody Isolation

Design of Mimetic Antibodies Targeting the SARS-CoV-2 Spike Glycoprotein Based on the GB1 Domain: A Molecular Simulation and Experimental Study

Authors: Anderson A. E Santo; Aline Reis; Anderson A. Pinheiro; Paulo I. da Costa; Gustavo T. Feliciano

Journal: Biochemistry

PubMed ID: 40096593

Doi: 10.1021/acs.biochem.4c00671

Structural insights into Ubr1-mediated N-degron polyubiquitination

Authors: Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu, Minglei Zhao

Journal: Nature.

PubMed ID: 34789879

Doi: 10.1038/s41586-021-04097-8

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EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Mol Cancer

PubMed ID: 34856977

Doi: 10.1186/s12943-021-01456-x

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Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway

Authors: Baorong Jiang, Gehui Yuan, Jialin Wu, Qian Wu, Lei Li, Ping Jiang

Journal: Biochim Biophys Acta Mol Basis Dis

Doi: 10.1016/j.bbadis.2021.166320

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Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes

Authors: Ziyi Guo, Xunjin Zeng, Yu Zheng

Journal: Bioengineered

PubMed ID: 34787067

Doi: 10.1080/21655979.2021.2005895

Products & Services: Protein and Antibody Isolation

Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ axis

Authors: Xiaohui Lu, Haijie Gao, Bo Zhu, Guilan Lin

Journal: Bioengineered

PubMed ID: 34546853

Doi: 10.1080/21655979.2021.1964157

Products & Services: DNA Sequencing

The Retropepsin-Type Protease APRc as a Novel Ig-Binding Protein and Moonlighting Immune Evasion Factor of

Authors: Pedro Curto, Andreia Barro, Carla Almeida, Ricardo S Vieira-Pires, Isaura Simões

Journal: MBio

PubMed ID: 34872352

Doi: 10.1128/mBio.03059-21

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The WalR-WalK signaling pathway modulates the activities of both CwlO and LytE through control of the peptidoglycan deacetylase PdaC in

Authors: Genevieve S Dobihal, Josué Flores-Kim, Ian J Roney, Xindan Wang, David Z Rudner

Journal: J Bacteriol

PubMed ID: 34871030

Doi: 10.1128/JB.00533-21

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Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci

Authors: Hongming Dong, Yaolei Zhang, Jiahao Wang, Haitao Xiang, Tianhang Lv, Likun Wei, Shaosen Yang, Xiaopan Liu, Bingzhao Ren, Xiuqing Zhang, Lirong Liu, Jun Cao, Meiniang Wang, Jiahai Shi, Naibo Yang

Journal: J Immunol

PubMed ID: 34880108

Doi: 10.4049/jimmunol.2100844

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Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins

Authors: Fatemeh Haghayegh, Razieh Salahandish, Azam Zare, Mahmood Khalghollah, Amir Sanati-Nezhad

Journal: Lab Chip

PubMed ID: 34860233

Doi: 10.1039/d1lc00879j

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Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis

Authors: Zachary G Beamer, Pratyush Routray, Won-Gyu Choi, Margaret K Spangler, Ansul Lokdarshi, Daniel M Roberts

Journal: Plant Physiol

PubMed ID: 34890456

Doi: 10.1093/plphys/kiab196

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Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

Authors: Nadia E Aikawa, Leonard V K Kupa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Emily F N Yuki, Carla G S Saad, Tatiana Pedrosa, Ricardo Fuller, Samuel K Shinjo, Percival D Sampaio-Barros, Danieli C O Andrade, Rosa M R Pereira, Luciana P C Seguro, Juliana M L Valim, Filipe Waridel, Ana Marli C Sartori, Alberto J S Duarte, Leila Antonangelo, Ester C Sabino, Paulo Rossi Menezes, Esper G Kallas, Clovis A Silva, Eloisa Bonfa

Journal: Lancet Rheumatol

PubMed ID: 34901885

Doi: 10.1016/S2665-9913(21)00327-1

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Cleavage-Free Human Genome Editing

Authors: Chenzhong Kuang, Yan Xiao, Dirk Hondmann

Journal: Mol Ther

PubMed ID: 34864205

Doi: 10.1016/j.ymthe.2021.12.001

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Aquaporin expression and cholesterol content in eel swimbladder tissue

Authors: Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P Cutler, Bernd Pelster

Journal: J Fish Biol

PubMed ID: 34882794

Doi: 10.1111/jfb.14973

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Novel Variations in the Gene Causing X-Linked Intellectual Disability

Authors: Po-Ming Wu, Wen-Hao Yu, Chi-Wu Chiang, Chen-Yu Wu, Jia-Shing Chen, Yi-Fang Tu

Journal: Neurol Genet

PubMed ID: 34877407

Doi: 10.1212/NXG.0000000000000646

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FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Authors: Wenlu Fan, Xiaoye Jin, Man Xu, Yongmei Xi, Weiguo Lu, Xiaohang Yang, Min-Xin Guan, Wanzhong Ge

Journal: Nucleic Acids Res

PubMed ID: 34878141

Doi: 10.1093/nar/gkab1187

Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Authors: Brandon M Lane, Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C Middleton, Kinsie Huggins, Amika Sood, Alejandro Ochoa, Andrew F Malone, Ricardo Vancini, Sara E Miller, Gentzon Hall, So Young Kim, David N Howell, Jameela A Kari, Rasheed Gbadegesin

Journal: JCI Insight

PubMed ID: 34874915

Doi: 10.1172/jci.insight.152102

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Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer

Authors: Jie Wang, Chen Zhang

Journal: Bioengineered

PubMed ID: 33682613

Doi: 10.1080/21655979.2021.1890377

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Generation and utility of a single-chain fragment variable monoclonal antibody platform against a baculovirus expressed recombinant receptor binding domain of SARS-CoV-2 spike protein

Authors: Reda Salem, Alaa A El-Kholy, Fatma R Waly, Dalia Ayman, Aya Sakr, Mai Hussein

Journal: Mol Immunol

PubMed ID: 34915268

Doi: 10.1016/j.molimm.2021.12.006

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ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit

Authors: Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luis Vázquez-Ibar

Journal: Emerg Microbes Infect

PubMed ID: 33372863

Doi: 10.1080/22221751.2020.1870413

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Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study

Authors: Hyun Jin Kim, Heon Jeong Yun, Jungok Kim, Sungmin Kym, Qute Choi

Journal: Vaccine

PubMed ID: 34953606

Doi: 10.1016/j.vaccine.2021.12.012

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Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Authors: Lorenzo Azzi, Daniela Dalla Gasperina, Giovanni Veronesi, Mariam Shallak, Giuseppe Ietto, Domenico Iovino, Andreina Baj, Francesco Gianfagna, Vittorio Maurino, Daniele Focosi, Fabrizio Maggi, Marco Mario Ferrario, Francesco Dentali, Giulio Carcano, Angelo Tagliabue, Lorenzo Stefano Maffioli, Roberto Sergio Accolla, Greta Forlani

Journal: EBioMedicine

PubMed ID: 34954658

Doi: 10.1016/j.ebiom.2021.103788

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Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method

Authors: Dafu Zhu, Haixia Su, Changqiang Ke, Chunping Tang, Matthias Witt, Ronald J Quinn, Yechun Xu, Jia Liu, Yang Ye

Journal: J Pharm Biomed Anal

PubMed ID: 34929567

Doi: 10.1016/j.jpba.2021.114538

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Convergent phenotypic evolution of rhodopsin for dim-light sensing across deep-diving vertebrates

Authors: Yu Xia , Yimeng Cui , Aishan Wang , Fangnan Liu , Hai Chi , Joshua H T Potter , Joseph Williamson , Xiaolan Chen , Stephen J Rossiter , Yang Liu

Journal: Mol Biol Evol

PubMed ID: 34463769

Doi: 10.1093/molbev/msab262

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Nano-immobilization of PETase enzyme for enhanced polyethylene terephthalate biodegradation

Authors: Yunpu Jia , Nadia A. Samak , Xuemi Hao , Zheng Chen , Gama Yang , Xuhao Zhao , Tingzhen Mu , Maohua Yang , Jianmin Xing

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2021.108205

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Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34893762

Doi: 10.1038/s42003-021-02940-2

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SlpB Protein Enhances the Probiotic Potential of NCDO 2118 in Colitis Mice Model

Authors: Giovanna A Belo, Bárbara F Cordeiro, Emiliano R Oliveira, Marina P Braga, Sara H da Silva, Bruno G Costa, Flaviano Dos S Martins, Gwénaël Jan, Yves Le Loir, Alfonso Gala-García, Enio Ferreira, Vasco Azevedo, Fillipe L R do Carmo

Journal: Front Pharmacol

PubMed ID: 34987390

Doi: 10.3389/fphar.2021.755825

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Gene-specific quantification of nascent transcription following targeted degradation of endogenous proteins in cultured cells

Authors: Alissa D Guarnaccia, April M Weissmiller, William P Tansey

Journal: STAR Protoc

PubMed ID: 34917979

Doi: 10.1016/j.xpro.2021.101000

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Deep mutational scanning for therapeutic antibody engineering

Authors: Kyrin R Hanning, Mason Minot, Annmaree K Warrender, William Kelton, Sai T Reddy

Journal: Trends Pharmacol Sci

PubMed ID: 34895944

Doi: 10.1016/j.tips.2021.11.010

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Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

Authors: Richard N Day, Kathleen H Day, Fredrick M Pavalko

Journal: PLoS ONE

PubMed ID: 34941939

Doi: 10.1371/journal.pone.0261660

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Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model

Authors: Gustavo Luis Verón, María Florencia Veiga, Mónica Cameo, Clara Isabel Marín-Briggiler, Mónica Hebe Vazquez-Levin

Journal: Cells

PubMed ID: 35011663

Doi: 10.3390/cells11010102

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Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

Authors: I-Ting Teng, Alexandra F Nazzari, Misook Choe, Tracy Liu, Matheus Oliveira de Souza, Yuliya Petrova, Yaroslav Tsybovsky, Shuishu Wang, Baoshan Zhang, Mykhaylo Artamonov, Bharat Madan, Aric Huang, Sheila N Lopez Acevedo, Xiaoli Pan, Tracy J Ruckwardt, Brandon J DeKosky, John R Mascola, John Misasi, Nancy J Sullivan, Tongqing Zhou, Peter D Kwong

Journal: PLoS ONE

PubMed ID: 35609088

Doi: 10.1101/2021.12.29.474491

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Single-Dose Vaccination of Recombinant Chimeric Newcastle Disease Virus (NDV) LaSota Vaccine Strain Expressing Infectious Bursal Disease Virus (IBDV) VP2 Gene Provides Full Protection against Genotype VII NDV and IBDV Challenge

Authors: Qilong Qiao, Mingzhen Song, Congcong Song, Yihang Zhang, Xiangdong Wang, Qing Huang, Baiyu Wang, Panpan Yang, Shiyi Zhao, Yongtao Li, Zeng Wang, Jun Zhao

Journal: Vaccines (Basel)

PubMed ID: 34960229

Doi: 10.3390/vaccines9121483

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Tandem mass tag (TMT)-based proteomic analysis of Cryptosporidium andersoni oocysts before and after excystation

Authors: Dong-Fang Li, Zhao-Hui Cui, Lu-Yang Wang, Kai-Hui Zhang, Le-Tian Cao, Shuang-Jian Zheng, Long-Xian Zhang

Journal: Parasit Vectors

PubMed ID: 34922597

Doi: 10.1186/s13071-021-05113-6

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Cryopreservation of network bioactivity and multi-lineage stromal cell differentiation potential within three-dimensional synthetic hydrogels

Authors:

Journal: Cryobiology

PubMed ID: 34922883

Doi: 10.1016/j.cryobiol.2021.12.003

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COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer

Authors: Cong Zeng, John P Evans, Karthik Chakravarthy, Panke Qu, Sarah Reisinger, No-Joon Song, Mark P Rubinstein, Peter G Shields, Zihai Li, Shan-Lu Liu

Journal: Cancer Cell

PubMed ID: 34986328

Doi: 10.1016/j.ccell.2021.12.014

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Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

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Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

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MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells

Authors: Siyuan Gao, Jing Zhao, Qinglei Xu, Yanli Guo, Mingzheng Liu, Chunlei Zhang, Allan P Schinckel, Bo Zhou

Journal: Theriogenology

PubMed ID: 34959084

Doi: 10.1016/j.theriogenology.2021.12.014

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Structural Insight into the Mechanism of PALB2 Interaction with MRG15

Authors: Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

Journal: Genes (Basel)

PubMed ID: 34946951

Doi: 10.3390/genes12122002

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The impact of benzo[a]pyrene on murine allergic airway inflammation via epigenetic remodeling

Authors: Xihua Wang, Shuyuan Guan, Lingbin Sun, Zhongliang Dai

Journal: Environ Toxicol Pharmacol

PubMed ID: 34883242

Doi: 10.1016/j.etap.2021.103782

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A metabolic labeling protocol to enrich myristoylated proteins from

Authors: Xin Gong, Yanwen Feng, Hongyun Tang

Journal: STAR Protoc

PubMed ID: 34917984

Doi: 10.1016/j.xpro.2021.101013

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Adenovirus-mediated RNA interference against herpes simplex virus infection in vitro

Authors: Lin Chen, Zhi-Qiang Pan, Chang-Bin Zhai

Journal: Folia Histochem Cytobiol

PubMed ID: 34905214

Doi: 10.5603/FHC.a2021.0031

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BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

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A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

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A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

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Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men

Authors: Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu, Biauw Chi Ong

Journal: Emerg Microbes Infect

PubMed ID: 34709140

Doi: 10.1080/22221751.2021.1999777

A Pathogen-Inducible Rice NAC Transcription Factor ONAC096 Contributes to Immunity Against and pv by Direct Binding to the Promoters of , Magnaprothe oryzae, and Xanthomonas oryzaeoryzae OsRap26 OsWRKY62 OsPAL1

Authors: Hui Wang, Yan Bi, Yizhou Gao, Yuqing Yan, Xi Yuan, Xiaohui Xiong, Jiajing Wang, Jiayu Liang, Dayong Li, Fengming Song

Journal: Front Plant Sci

PubMed ID: 34956298

Doi: 10.3389/fpls.2021.802758

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Nanopore-based measurement of the interaction of P450cam monooxygenase and putidaredoxin at the single-molecule level

Authors: Hui Chen, Yao Lin, Yi-Tao Long, Shelley D Minteer, Yi-Lun Ying

Journal: Faraday Discuss

PubMed ID: 34889330

Doi: 10.1039/d1fd00042j

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Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Authors: Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi

Journal: Biomedicines

PubMed ID: 34944698

Doi: 10.3390/biomedicines9121882

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Synergistic enzyme cocktail between levansucrase and inulosucrase for superb levan-type fructooligosaccharide synthesis

Authors: Karan Wangpaiboon, Methus Klaewkla, Thanapon Charoenwongpaiboon, Napas Vongkusolkit, Pawinee Panpetch, Kamontip Kuttiyawong, Wonnop Visessanguan, Rath Pichyangkura

Journal: Enzyme Microb Technol

PubMed ID: 34923315

Doi: 10.1016/j.enzmictec.2021.109960

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Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

Authors: Marie-Claude Gaudreau, Radhika R Gudi, Gongbo Li, Benjamin M Johnson, Chenthamarakshan Vasu

Journal: Autoimmunity

PubMed ID: 34882054

Doi: 10.1080/08916934.2021.2012165

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Novel sequential immunocapture microflow LC/MS/MS approach to measuring PTH-Fc protein in human serum

Authors: Haixing Wang, Jiang Wu, Peng Pan, Thuy Nguyen, Michael Cwik, Ling Morgan

Journal: Bioanalysis

PubMed ID: 34894717

Doi: 10.4155/bio-2021-0233

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Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides

Authors: Francesca Troilo, Marco Pedretti, Carlo Travaglini-Allocatelli, Alessandra Astegno, Adele Di Matteo

Journal: Biochem Biophys Res Commun

PubMed ID: 34974297

Doi: 10.1016/j.bbrc.2021.12.077

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Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding

Authors: Lori I Robins, Erika K Keim, Deborah B Robins, John S Edgar, John S Meschke, Philip R Gafken, Jeffrey F Williams

Journal: ACS Omega

PubMed ID: 34984290

Doi: 10.1021/acsomega.1c05297

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An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

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Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

Authors: Yifan Ge, Sivakumar Boopathy, Tran H Nguyen, Camila Makhlouta Lugo, Luke H Chao

Journal: Front Mol Biosci

PubMed ID: 35004847

Doi: 10.3389/fmolb.2021.769135

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MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Authors: Yan Li, Nianling Yao, Yan Gao, Yunping Wang, Lu Bai, Jia Xu, Haixu Wang

Journal: Bioengineered

PubMed ID: 34637688

Doi: 10.1080/21655979.2021.1987125

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Genome-wide identification and expression analysis of ammonium transporter 1 (AMT1) gene family in cassava ( Crantz) and functional analysis of in transgenic

Authors: Youquan Xia, Yindi Liu, Tingting Zhang, Yu Wang, Xingyu Jiang, Yang Zhou

Journal: 3 Biotech

PubMed ID: 34926117

Doi: 10.1007/s13205-021-03070-6

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Immunization with short peptide particles reveals a functional CD8 T-cell neoepitope in a murine renal carcinoma model

Authors: Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott I Abrams, John M L Ebos, Jonathan F Lovell

Journal: J Immunother Cancer

PubMed ID: 34862254

Doi: 10.1136/jitc-2021-003101

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Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

Authors: Wei-Shuo Lin, I-Chen Chen, Hui-Chen Chen, Yi-Chien Lee, Suh-Chin Wu

Journal: Front Immunol

PubMed ID: 34925381

Doi: 10.3389/fimmu.2021.795741

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Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Proteins

Authors: Clara L Kielkopf, William Bauer, Ina L Urbatsch

Journal: Cold Spring Harb Protoc

PubMed ID: 34853120

Doi: 10.1101/pdb.prot102228

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CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

Authors: Siyu Liu, Jintao Zhang, Zine Eddine Kherraf, Shuya Sun, Xin Zhang, Caroline Cazin, Charles Coutton, Raoudha Zouari, Shuqin Zhao, Fan Hu, Selima Fourati Ben Mustapha, Christophe Arnoult, Pierre F Ray, Mingxi Liu

Journal: Development

PubMed ID: 34792097

Doi: 10.1242/dev.199805

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Phylogeny of Leptographium qinlingensis cytochrome P450 genes and transcription levels of six CYPs in response to different nutrition media or terpenoids

Authors: Lulu Dai, Jie Zheng, Jiaqi Ye, Hui Chen

Journal: Arch Microbiol

PubMed ID: 34894279

Doi: 10.1007/s00203-021-02616-9

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Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Authors: Ru Dong, Cheng Zhang, Chao Wang, Xin Zhou, Wen Li, Jin-Yang Zhang, Min Wang, Yong Xu, Li-Ping Sun

Journal: Bioorg Med Chem

PubMed ID: 34999525

Doi: 10.1016/j.bmc.2021.116592

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ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes

Authors: Jessica M Hong, Michael Gibbons, Ali Bashir, Diana Wu, Shirley Shao, Zachary Cutts, Mariya Chavarha, Ye Chen, Lauren Schiff, Mikelle Foster, Victoria A Church, Llyke Ching, Sara Ahadi, Anna Hieu-Thao Le, Alexander Tran, Michelle Dimon, Marc Coram, Brian Williams, Phillip Jess, Marc Berndl, Annalisa Pawlosky

Journal: iScience

PubMed ID: 35005536

Doi: 10.1016/j.isci.2021.103586

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NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes

Authors: Juan Fan, Jiawei Shi, Yong Zhang, Junwei Liu, Chenyi An, Huaying Zhu, Peng Wu, Wei Hu, Rui Qin, Danmei Yao, Xin Shou, Yibing Xu, Zhou Tong, Xue Wen, Jianpo Xu, Jin Zhang, Weijia Fang, Jizhong Lou, Weiwei Yin, Wei Chen

Journal: EMBO J

PubMed ID: 34913508

Doi: 10.15252/embj.2021107739

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Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases

Authors: Bruno Gualano, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J Pinto, Bruna C Mazzolani, Fabiana I Smaira, Sofia M Sieczkowska, Nadia E Aikawa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuk, Clovis A Silva, Paul Swinton, Pedro C Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Brain Behav Immun

PubMed ID: 34954325

Doi: 10.1016/j.bbi.2021.12.016

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The large nonstructural protein (NS1) of the human bocavirus 1 (HBoV1) directly interacts with Ku70, which plays an important role in virus replication in human airway epithelia

Authors: Liting Shao, Kang Ning, Jianke Wang, Fang Cheng, Shengqi Wang, Jianming Qiu

Journal: J Virol

PubMed ID: 34878919

Doi: 10.1128/JVI.01840-21

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Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins

Authors: Jieping Deng , Junping Pan, Minghui Qiu, Lipeng Mao , Zhigang Wang , Guodong Zhu , Lijuan Gao , Jun Su , Yutian Hu , Oscar Junhong Luo , Guobing Chen , Pengcheng Wang

Journal: J Leukoc Biol

PubMed ID: 34231935

Doi: 10.1002/JLB.4MA0621-020R

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Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice

Authors: Wenjuan Li , Xingxing Li , Danhua Zhao , Jingjing Liu , Ling Wang , Miao Li , Xinyu Liu , Jia Li , Xiaohong Wu , Yuhua Li

Journal: Signal Transduct Target Ther

PubMed ID: 34903732

Doi: 10.1038/s41392-021-00843-6

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