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Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses

Authors: Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan

Journal: J Immunol

PubMed ID: 34645689

Doi: 10.4049/jimmunol.2100144

Products & Services: Peptide Synthesis

Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis

Authors: Tao Zhang, Guangquan Zhang, Wenbo Yang, Hongze Chen, Jisheng Hu, Zhongjie Zhao, Chundong Cheng, Guanqun Li, Yu Xie, Yilong Li, Rui Kong, Yongwei Wang, Gang Wang, Hua Chen, Xue-Wei Bai, Shangha Pan, Bei Sun, Le Li

Journal: Cell Death Dis

PubMed ID: 34697288

Doi: 10.1038/s41419-021-04236-z

Products & Services: Gene Synthesis

Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein

Authors: Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas W Morrell, Paul D Upton, Carmelo Bernabeu

Journal: Int J Mol Sci

PubMed ID: 34681942

Doi: 10.3390/ijms222011282

Products & Services: Plasmid DNA Preparation

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

Authors: David G Alleva, Andrea R Delpero, Melanie M Scully, Sylaja Murikipudi, Ramya Ragupathy, Emma K Greaves, Thillainaygam Sathiyaseelan, Jeffrey R Haworth, Nishit J Shah, Vidhya Rao, Shashikant Nagre, Thomas M Lancaster, Sarah S Webb, Allison I Jasa, Shannon E Ronca, Freedom M Green, Hanne Andersen Elyard, JoAnn Yee, Jeffrey Klein, Larry Karnes, Frans Sollie, Todd C Zion

Journal: Vaccine

PubMed ID: 34642088

Doi: 10.1016/j.vaccine.2021.09.077

Products & Services: Endotoxin Detection & Removal System

AgMYB12, a novel R2R3-MYB transcription factor, regulates apigenin biosynthesis by interacting with the AgFNS gene in celery

Authors: Hao Wang, Jie-Xia Liu, Kai Feng, Tong Li, Ao-Qi Duan, Yan-Hua Liu, Hui Liu, Ai-Sheng Xiong

Journal: Plant Cell Rep

PubMed ID: 34601645

Doi: 10.1007/s00299-021-02792-4

Products & Services: DNA Sequencing

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

Authors: Carolina Lucas, Chantal B F Vogels, Inci Yildirim, Jessica E Rothman, Peiwen Lu, Valter Monteiro, Jeff R Gelhausen, Melissa Campbell, Julio Silva, Alexandra Tabachikova, Mario A Peña-Hernandez, M Catherine Muenker, Mallery I Breban, Joseph R Fauver, Subhasis Mohanty, Jiefang Huang, Albert C Shaw, Albert I Ko, Saad B Omer, Nathan D Grubaugh, Akiko Iwasaki

Journal: Nature

PubMed ID: 34634791

Doi: 10.1038/s41586-021-04085-y

Products & Services: Mammalian Expression

Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome

Authors: Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang

Journal: FASEB J

PubMed ID: 34516679

Doi: 10.1096/fj.202101030R

Products & Services: Protein and Antibody Isolation

JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance

Authors: Dongjoo You, Byung Chul Jung, Sneha Damal Villivalam, Hee-Woong Lim, Sona Kang

Journal: Diabetes

PubMed ID: 34686520

Doi: 10.2337/db21-0596

Products & Services: Catalog Antibodies

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Authors: Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L Pierri, Anna De Grassi, Niamh C Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A J O'Neill, Vittoria Infantino

Journal: Cells

PubMed ID: 34831186

Doi: 10.3390/cells10112962

Products & Services: Mutant Libraries

Effect of Amelotin on Bone Growth in the Murine Calvarial Defect Model

Authors: Daiki Tanaka, Yuichi Ikeda, Eri Ikeda, Mako Yokose, Bernhard Ganss, Takanori Iwata

Journal: Ann Biomed Eng

PubMed ID: 34608582

Doi: 10.1007/s10439-021-02867-z

Products & Services: Protein and Antibody Isolation

Nep1‐like Proteins from Valsa mali Differentially Regulate Pathogen Virulence and Response to Abiotic Stresses

Authors: Jianying Liu, Jiajun Nie, Yali Chang, Lili Huang

Journal: Journal of Fungi

Doi: 10.3390/jof7100830

Products & Services: Peptide Synthesis

Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Authors: Chenxi Li, Yanyang Zhou, Xuan Chen, Yanbing Zhang, Jingbo Hu, Cicheng Ren, Jingjing Ding, Daoyuan Jiang, Yanhua Li

Journal: Dev Comp Immunol

PubMed ID: 34626690

Doi: 10.1016/j.dci.2021.104290

Products & Services: Gene Synthesis

USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates

Authors: Thang Van Nguyen

Journal: Proc Natl Acad Sci USA

PubMed ID: 34583995

Products & Services: Plasmid DNA Preparation

Roles of Small Subunits of Laccase (ssPOXA3a/b) in Laccase Production by Pleurotus eryngii var. ferulae

Authors: Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding

Journal: J Agric Food Chem.

PubMed ID: 34696587

Doi: doi.org/10.1021/acs.jafc.1c04777

Products & Services: Protein Electrophoresis and Western

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

Authors: Isabel Pablos, Yoan Machado, Hugo C Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A Bell, Georgina S Butler, Peter M Grin, Quynh T Cao, Jenny P Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N Kizhakkedathu, Karen Mossman, Jeremy A Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M Overall

Journal: Cell Rep

PubMed ID: 34672947

Doi: 10.1016/j.celrep.2021.109892

Products & Services: Gene Synthesis Peptide Library Services ORF cDNA Clones/MolecularCloud

SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors: Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong

Journal: Signal Transduct Target Ther

PubMed ID: 34645784

Doi: 10.1038/s41392-021-00777-z

Products & Services: Serology SARS-Cov-2 detection kits

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Authors: Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang , Xu Li

Journal: Dev Cell

PubMed ID: 34626540

Doi: 10.1016/j.devcel.2021.09.015

Products & Services: Catalog Antibodies

CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense

Authors: Xue-Peng Li, Guan-Yu Chen, Qiu Jin, Fang-Rui Lou, Bing-Jian Liu, Jian Zhang, Ji-Xing Feng, Tian-Tian Chen

Journal: Int J Biol Macromol

PubMed ID: 34666131

Doi: 10.1016/j.ijbiomac.2021.10.080

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Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Authors: Yan Li, Siyu Shen, Haoran Guo, Zhe Zhang, Lili Zhang, Qingran Yang, Yanhang Gao, Junqi Niu, Wei Wei

Journal: Front Microbiol

PubMed ID: 34733242

Doi: 10.3389/fmicb.2021.706241

Products & Services: Protein and Antibody Isolation

Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Authors: Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34628068

Doi: 10.1016/j.parint.2021.102479

Products & Services: Protein and Antibody Isolation

The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3 Against With No Detectable Resistance

Authors: Depeng Zhu, Fangyi Chen, Yan-Chao Chen, Hui Peng, Ke-Jian Wang

Journal: Front Cell Infect Microbiol

PubMed ID: 34676176

Doi: 10.3389/fcimb.2021.752637

Products & Services: Protein and Antibody Isolation

Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana

Authors: Tong Zhu, Xue Zhou, Jian-Long Zhang, Wei-Hao Zhang, Li-Pei Zhang, Chun-Xiang You, Paula E Jameson, Peng-Tao Ma, Shan-Li Guo

Journal: Mol Plant Pathol

PubMed ID: 34633738

Doi: 10.1111/mpp.13139

Products & Services: Protein and Antibody Isolation

NORHA, a novel follicular atresia-related lncRNA, promotes porcine granulosa cell apoptosis via the miR-183-96-182 cluster and FoxO1 axis

Authors: Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li

Journal: J Anim Sci Biotechnol

PubMed ID: 34615552

Doi: 10.1186/s40104-021-00626-7

Products & Services: Protein and Antibody Isolation

Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Authors: Poorya Sadeghi, Hessamaddin Sohrabi, Maryam Hejazi, Ali Jahanban-Esfahlan, Behzad Baradaran, Maryam Tohidast, Mir Reza Majidi, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar, Miguel de la Guardia

Journal: Trends Analyt Chem

PubMed ID: 34697511

Doi: 10.1016/j.trac.2021.116460

Products & Services: Protein and Antibody Isolation

Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8 T cells

Authors: Margot Miranda-Katz, John J Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John V Williams

Journal: Sci Rep

PubMed ID: 34675220

Doi: 10.1038/s41598-021-00023-0

Products & Services: Protein and Antibody Isolation

Arabidopsis fibrillin 1-2 subfamily exerts their functions via specific protein-protein interactions

Authors: Diego Torres-Romero, Ángeles Gómez-Zambrano, Antonio Jesús Serrato, Mariam Sahrawy, Ángel Mérida

Journal: J Exp Bot

PubMed ID: 34651644

Doi: 10.1093/jxb/erab452

Products & Services: Polyclonal Antibody Services

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Authors: Kathryn McGuckin Wuertz, Erica K Barkei, Wei-Hung Chen, Elizabeth J Martinez, Ines Lakhal-Naouar, Linda L Jagodzinski, Dominic Paquin-Proulx, Gregory D Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V Thomas, Rajeshwer S Sankhala, Agnes Hajduczki, Caroline E Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F Wood, Jeffrey W Froude, Matthew Gagne, Amy R Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J Krebs, Andrew S Pekosz, Jeffrey R Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G Lewis, Sandhya Vasan, Mehul Suthar, Victoria R Polonis, Gary R Matyas, Eli A Boritz, Daniel C Douek, Robert A Seder, Sharon P Daye, Mangala Rao, Sheila A Peel, M Gordon Joyce, Diane L Bolton, Nelson L Michael, Kayvon Modjarrad

Journal: npj Vaccines

PubMed ID: 34711815

Doi: 10.1038/s41541-021-00392-7

Products & Services: Plasmid DNA Preparation

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

Authors: Nitzan Tal, Benjamin R Morehouse, Adi Millman, Avigail Stokar-Avihail, Carmel Avraham, Taya Fedorenko, Erez Yirmiya, Ehud Herbst, Alexander Brandis, Tevie Mehlman, Yaara Oppenheimer-Shaanan, Alexander F A Keszei, Sichen Shao, Gil Amitai, Philip J Kranzusch, Rotem Sorek

Journal: Cell

PubMed ID: 34644530

Doi: 10.1016/j.cell.2021.09.031

Products & Services: Plasmid DNA Preparation

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Authors: Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton

Journal: Nat Commun

PubMed ID: 34663813

Doi: 10.1038/s41467-021-26239-2

Products & Services: Plasmid DNA Preparation

Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

Authors: Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang

Journal: npj Vaccines

PubMed ID: 34611173

Doi: 10.1038/s41541-021-00382-9

Products & Services: Plasmid DNA Preparation

Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ()

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S Hayward, Paul D Ling

Journal: Microbiol Spectr

PubMed ID: 34668724

Doi: 10.1128/Spectrum.00983-21

Products & Services: Plasmid DNA Preparation

Genome Editing of Rice Loci Confers Partial Resistance to Rice Black-Streaked Dwarf Virus

Authors: Wei Wang, Shuhui Ma, Peng Hu, Yinghua Ji, Feng Sun

Journal: Viruses

PubMed ID: 34696530

Doi: 10.3390/v13102100

Products & Services: PCR Cloning and Subcloning

LncRNA DUXAP10 Upregulation and the Hedgehog Pathway Activation Are Critically Involved in Chronic Cadmium Exposure-Induced Cancer Stem Cell-Like Property

Authors: Hsuan-Pei Lin, Zhishan Wang, Chengfeng Yang

Journal: Toxicol Sci

PubMed ID: 34373904

Doi: 10.1093/toxsci/kfab099

Products & Services: PCR Cloning and Subcloning

Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins

Authors: Feiyue Cheng, Rui Wang, Haiying Yu, Chao Liu, Jun Yang, Hua Xiang, Ming Li

Journal: Nucleic Acids Res

PubMed ID: 34551428

Doi: 10.1093/nar/gkab821

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The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress

Authors: Jun Tian, Yaojun Wang, Ming Ding, Yue Zhang, Jiaoni Chi, Tao Wang, Bin Jiao, Zhe Jian, Xiuli Yi, Ye Huang, Ling Liu, Kai Li, Jiaxi Chen, Gang Wang, Tianwen Gao, Chunying Li, Qiang Li

Journal: Oxid Med Cell Longev

PubMed ID: 34745423

Doi: 10.1155/2021/7617839

Products & Services: Nucleic Acid Purification

Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

Authors: Hüsün Sheyma Kizilkaya, Kimmie Vestergaard Sørensen, Camilla J Kibsgaard, Laerke Smidt Gasbjerg, Alexander S Hauser, Alexander Hovard Sparre-Ulrich, Niels Grarup, Mette M Rosenkilde

Journal: Front Cell Dev Biol

PubMed ID: 34760890

Doi: 10.3389/fcell.2021.749607

Products & Services: Mutant Libraries

Turnover of diacylglycerol kinase 4 by cytoplasmic acidification induces vacuole morphological change and nuclear DNA degradation in the early stage of pear self-incompatibility response

Authors: Xiao-Xiong Kong, Jia-Wei Mei, Jing Zhang, Xiao Liu, Ju-You Wu, Chun-Lei Wang

Journal: J Integr Plant Biol

PubMed ID: 34655280

Doi: 10.1111/jipb.13180

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Genome-wide analysis of the maize superoxide dismutase (SOD) gene family reveals important roles in drought and salt responses

Authors: Jing Liu, Lijuan Xu, Jian Shang, Xiaolin Hu, Haitao Yu, Hongying Wu, Wenben Lv, Yang Zhao

Journal: Genet Mol Biol

PubMed ID: 34606562

Doi: 10.1590/1678-4685-GMB-2021-0035

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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Authors: Su-Jeong Kim, Anjali Devgan, Brendan Miller, Sam Mool Lee, Hiroshi Kumagai, Kenneth A Wilson, Gabriella Wassef, Richard Wong, Hemal H Mehta, Pinchas Cohen, Kelvin Yen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34624450

Doi: 10.1016/j.bbagen.2021.130017

Products & Services: Mammalian Expression

Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides

Authors: Matevž Rumpret, Helen J von Richthofen, Maarten van der Linden, Geertje H A Westerlaken, Cami Talavera Ormeño, Jos A G van Strijp, Meytal Landau, Huib Ovaa, Nina M van Sorge, Linde Meyaard

Journal: FASEB J

PubMed ID: 34533845

Doi: 10.1096/fj.202100812R

Products & Services: Mammalian Expression

fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling During Seed Germination and Seedling Development

Authors: Lin Liang, Qi Wang, Zihao Song, Yaxin Wu, Qing Liang, Qingsong Wang, Jinli Yang, Ying Bi, Wen Zhou, Liu-Min Fan

Journal: Front Plant Sci

PubMed ID: 34712252

Doi: 10.3389/fpls.2021.724144

Products & Services: Mammalian Expression

A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons

Authors: Blaise M Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N Bledsoe, Bryanna N Vacca, Tullia V Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G Klein

Journal: Pharmacol Res Perspect

PubMed ID: 34476911

Doi: 10.1002/prp2.859

Products & Services: Mammalian Expression

Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication

Authors: Charlotte Flory, Kitti Wing Ki Chan, Amanda Makha Bifani, Milly Ming Ju Choy, Julien Lescar, Eng Eong Ooi, Norbert Tautz, Subhash G Vasudevan

Journal: Antiviral Res

PubMed ID: 34699863

Doi: 10.1016/j.antiviral.2021.105194

Products & Services: Gene Fragments

The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni

Authors: Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie

Journal: Nucleic Acids Res

PubMed ID: 34551436

Doi: 10.1093/nar/gkab818

Products & Services: Gene Fragments

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Authors: Peter J Chen, Jeffrey A Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W Nelson, Gregory A Newby, Mustafa Sahin, Mark J Osborn, Jonathan S Weissman, Britt Adamson, David R Liu

Journal: Cell

PubMed ID: 34653350

Doi: 10.1016/j.cell.2021.09.018

Products & Services: Gene Fragments

Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway

Authors: Haoming Wu, Yang Wang, Qianqian Yao, Linlin Fan, Lu Meng, Nan Zheng, Huiying Li, Jiaqi Wang

Journal: Int Immunopharmacol

PubMed ID: 34634739

Doi: 10.1016/j.intimp.2021.108149

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Incorporating health co-benefits into technology pathways to achieve China's 2060 carbon neutrality goal: a modelling study

Authors: Shihui Zhang, Kangxin An, Jin Li, Yuwei Weng, Shaohui Zhang, Shuxiao Wang, Wenjia Cai, Can Wang, Peng Gong

Journal: Lancet Planet Health

PubMed ID: 34758346

Doi: 10.1016/S2542-5196(21)00252-7

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Authors: Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Aylwin Ng, Timothy Lehmberg, Archana Jha, Sravya Kommineni, Katherine Fletcher, Jorge Garcia-Fortanet, Yaya Fan, Qing Tang, Menghao Wei, Asmita Agrawal, Sagar R Budhe, Sreekanth R Rouduri, Dan Baird, Jeff Saunders, Janna Kiselar, Mark R Chance, Andrea Ballabio, Brent A Appleton, John H Brumell, Oliver Florey, Leon O Murphy

Journal: Sci Adv

PubMed ID: 34597140

Doi: 10.1126/sciadv.abj2485

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Identification of a MarR subfamily that regulates arsenic resistance genes

Authors: Yanshuang Yu, Jichen Chen, Yuanping Li, Jinxuan Liang, Zhenchen Xie, Renwei Feng, Hend A Alwathnani, Barry P Rosen, Anne Grove, Jian Chen, Christopher Rensing

Journal: Appl Environ Microbiol

PubMed ID: 34613763

Doi: 10.1128/AEM.01588-21

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Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta

Authors: Zhan-Ku Shi, Xiao-Wei Gong, Jiang-Yuan Zhao, Ming-Gang Li, Xiu-Lin Han, Meng-Liang Wen

Journal: J Oleo Sci

PubMed ID: 34645748

Doi: 10.5650/jos.ess21172

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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS-CoV and MERS-CoV MDs in the free and the ADPr-bound state

Authors: Aikaterini C Tsika, Nikolaos K Fourkiotis, Periklis Charalampous, Angelo Gallo, Georgios A Spyroulias

Journal: Biomol NMR Assign

PubMed ID: 34686999

Doi: 10.1007/s12104-021-10052-5

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I-SceI and customized meganucleases-mediated genome editing in tomato and oilseed rape

Authors: Benoit Danilo, Émilie Montes, Héloïse Archambeau, Maryse Lodé, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre, Marianne Mazier

Journal: Transgenic Res

PubMed ID: 34632562

Doi: 10.1007/s11248-021-00287-2

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Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits

Authors: Sumin Kang, Nam Hyuk Kim, Yeon Gyu Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 34739856

Doi: 10.1016/j.bbrc.2021.10.071

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

Authors: Melanie de Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A Versteeg, David Haselbach, Johannes Zuber

Journal: Nature

PubMed ID: 34711951

Doi: 10.1038/s41586-021-04035-8

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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice

Authors: Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z M Homer, Rosana Leiva, Santiago Vázquez, Damian J Mole, Christian Griñán-Ferré, Mercè Pallàs

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681264

Doi: 10.3390/ph14101040

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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line

Authors: Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço

Journal: Mutat Res

PubMed ID: 34710701

Doi: 10.1016/j.mrfmmm.2021.111763

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A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain

Authors: Kofi Abokitse, Stephan Grosse, Hannes Leisch, Christopher R Corbeil, Florence Perrin-Sarazin, Peter C K Lau

Journal: Appl Environ Microbiol

PubMed ID: 34705546

Doi: 10.1128/AEM.01522-21

Products & Services: Codon Optimization

Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy

Authors: Anish Jadav, Kevin Truong

Journal: Integr Biol (Camb)

PubMed ID: 34632498

Doi: 10.1093/intbio/zyab015

Products & Services: Codon Optimization

Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Authors: Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson

Journal: Biochemistry

PubMed ID: 34609847

Doi: 10.1021/acs.biochem.1c00600

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The pentatricopeptide repeat protein EMB1270 interacts with CFM2 to splice specific group II introns in Arabidopsis chloroplasts

Authors: Li Zhang, Jingli Chen, Liqun Zhang, Ying Wei, Yajuan Li, Xinyun Xu, Hui Wu, Zhong-Nan Yang, Jirong Huang, Fenhong Hu, Weihua Huang, Yong-Lan Cui

Journal: J Integr Plant Biol

PubMed ID: 34427970

Doi: 10.1111/jipb.13165

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Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries

Authors: Sreeparna Biswas, Priyanka Garg, Somnath Dutta, Kaza Suguna

Journal: Sci Rep

PubMed ID: 34697325

Doi: 10.1038/s41598-021-00172-2

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An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel

Authors: Valeria Guzman-Luna, Andrew M Fuchs, Anna J Allen, Alexios Staikos, Silvia Cavagnero

Journal: Commun Biol

PubMed ID: 34716402

Doi: 10.1038/s42003-021-02752-4

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N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

Authors: Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein

Journal: J Biol Chem

PubMed ID: 34732320

Doi: 10.1016/j.jbc.2021.101363

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Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection

Authors: Patrícia Mertinková, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, Mangesh Bhide

Journal: Sci Rep

PubMed ID: 34635758

Doi: 10.1038/s41598-021-99696-w

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Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen Vibrio alginolyticus

Authors: Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao

Journal: Microbiol Res

PubMed ID: 34700184

Doi: 10.1016/j.micres.2021.126900

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Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease

Authors: Giorgio Fedele, Gianluca Russo, Ilaria Schiavoni, Pasqualina Leone, Eleonora Olivetta, Valentina Perri, Maria Antonella Zingaropoli, Maria Rosa Ciardi, Patrizia Pasculli, Claudio Maria Mastroianni, Paola Stefanelli

Journal: Diagn Microbiol Infect Dis

PubMed ID: 34742119

Doi: 10.1016/j.diagmicrobio.2021.115586

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and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Authors: Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 34532729

Doi: 10.1039/d1fo02172a

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Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy

Authors: S Strazdaite, S J Roeters, A Sakalauskas, T Sneideris, J Kirschner, K B Pedersen, B Schiøtt, F Jensen, T Weidner, V Smirnovas, G Niaura

Journal: J Phys Chem B

PubMed ID: 34597059

Doi: 10.1021/acs.jpcb.1c04882

Guillain-Barré syndrome after coronavirus disease 2019 vaccine: A temporal association

Authors: Gustavo Figueiredo da Silva, Caroline Figueiredo da Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Fabiana Romancini, Rafael Marques Mendes, Amanda Locks, Maria Francisca Moro Longo, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Vera Lucia Braatz

Journal: Clin Exp Neuroimmunol

PubMed ID: 34900000

Doi: 10.1111/cen3.12678

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Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins

Authors: Ashish A Kawale, Björn M Burmann

Journal: STAR Protoc

PubMed ID: 34761231

Doi: 10.1016/j.xpro.2021.100919

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The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression

Authors: Yingying Gao, Jinrui Yang, Xiaobei Zhang, Aizhong Chen, Zhouhang Gu, Zhiyou Du

Journal: Front Microbiol

PubMed ID: 34745069

Doi: 10.3389/fmicb.2021.760937

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A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites

Authors: Tianze Zhang, Chenyang Li, Mengji Cao, Dan Wang, Qi Wang, Yi Xie, Shibo Gao, Shuai Fu, Xueping Zhou, Jianxiang Wu

Journal: Front Microbiol

PubMed ID: 34721366

Doi: 10.3389/fmicb.2021.757451

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Mutations Suppressing the Lack of Prepilin Peptidase Provide Insights Into the Maturation of the Major Pilin Protein in Cyanobacteria

Authors: Markéta Linhartová, Petra Skotnicová, Kaisa Hakkila, Martin Tichý, Josef Komenda, Jana Knoppová, Joan F Gilabert, Victor Guallar, Taina Tyystjärvi, Roman Sobotka

Journal: Front Microbiol

PubMed ID: 34712217

Doi: 10.3389/fmicb.2021.756912

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Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Authors: Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco

Journal: Front Pharmacol

PubMed ID: 34671260

Doi: 10.3389/fphar.2021.746628

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Effectively auto-regulated adsorption and recovery of rare earth elements via an engineered E coli

Authors: Xiaoman Xie, Xirui Tan, Yiyan Yu, Yunchong Li, Pengbo Wang, Yuanhao Liang, Yunjun Yan

Journal: J Hazard Mater

PubMed ID: 34775317

Doi: 10.1016/j.jhazmat.2021.127642

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Authors: Lorenzo Gamberini, Carlo Alberto Mazzoli, Irene Prediletto, Harri Sintonen, Gaetano Scaramuzzo, Davide Allegri, Davide Colombo, Tommaso Tonetti, Gianluca Zani, Chiara Capozzi, Giorgia Dalpiaz, Vanni Agnoletti, Iacopo Cappellini, Gabriele Melegari, Federica Damiani, Maurizio Fusari, Giovanni Gordini, Cristiana Laici, Maria Concetta Lanza, Mirco Leo, Andrea Marudi, Raffaella Papa, Antonella Potalivo, Jonathan Montomoli, Stefania Taddei, Massimiliano Mazzolini, Anna Filomena Ferravante, Roberta Nicali, Vito Marco Ranieri, Emanuele Russo, Carlo Alberto Volta, Savino Spadaro

Journal: Respir Med

PubMed ID: 34717097

Doi: 10.1016/j.rmed.2021.106665

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The novel ORFV protein ORFV113 activates LPA-p38 signaling

Authors: Sushil Khatiwada, Gustavo Delhon, Sabal Chaulagain, Daniel L Rock

Journal: PLoS Pathog

PubMed ID: 34614034

Doi: 10.1371/journal.ppat.1009971

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Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3

Authors: Bingting Ma, Cuiqing Huang, Jun Ma, Ye Xiang, Xinzheng Zhang

Journal: Nature

PubMed ID: 34646021

Doi: 10.1038/s41586-021-03909-1

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Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis

Authors: Yang Jiang, Xiao-Yu Yu, Hui-Xin Sun, Xin-Yue Gu, Jing-Shu Geng

Journal: J Physiol Biochem

PubMed ID: 34671931

Doi: 10.1007/s13105-021-00832-x

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The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series

Authors: Min Sun, Jonathan W Mueller, Lorna C Gilligan, Angela E Taylor, Fozia Shaheen, Anna Noczyńska, Guy T'Sjoen, Louise Denvir, Savitha Shenoy, Piers Fulton, Timothy D Cheetham, Helena Gleeson, Mushtaqur Rahman, Nils P Krone, Norman F Taylor, Cedric H L Shackleton, Wiebke Arlt, Jan Idkowiak

Journal: Eur J Endocrinol

PubMed ID: 34524979

Doi: 10.1530/EJE-21-0152

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Structural evidence for visual arrestin priming via complexation of phosphoinositols

Authors: Christopher L Sander, Jennings Luu, Kyumhyuk Kim, David Furkert, Kiyoung Jang, Joerg Reichenwallner, MinSoung Kang, Ho-Jun Lee, Bryan T Eger, Hui-Woog Choe, Dorothea Fiedler, Oliver P Ernst, Yong Ju Kim, Krzysztof Palczewski, Philip D Kiser

Journal: Structure

PubMed ID: 34678158

Doi: 10.1016/j.str.2021.10.002

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SARS-CoV-2 Neutralizing Antibody Levels Post COVID-19 Vaccination Based on ELISA Method-A Small Real-World Sample Exploration

Authors: Xiaoguang Li, Chao Liang, Xiumei Xiao

Journal: Vaccines (Basel)

PubMed ID: 34696247

Doi: 10.3390/vaccines9101139

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Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway

Authors: Yan Wu, Gaolin Qiu, Hainie Zhang, Leilei Zhu, Gao Cheng, Yiqiao Wang, Yuanhai Li, Weiwei Wu

Journal: J Cell Mol Med

PubMed ID: 34664412

Doi: 10.1111/jcmm.16871

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Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4

Authors: Erin M O'Brien, Kara L Spiller

Journal: J Leukoc Biol

PubMed ID: 34643290

Doi: 10.1002/JLB.3A0520-338R

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SARS-CoV-2 Delta variant infects ACE2 primary human bronchial epithelial cells more efficiently than other variants

Authors: Hongmei Li, Ting Liu, Liping Wang, Minghui Wang, Shaoqing Wang

Journal: J Med Virol

PubMed ID: 34596249

Doi: 10.1002/jmv.27372

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Assessment of Anti-SARS-CoV-2 Antibodies Post-Coronavac Vaccination in the Amazon Region of Brazil

Authors: Carlos David Araújo Bichara, Maria Alice Freitas Queiroz, Ednelza da Silva Graça Amoras, Gergiane Lopes Vaz, Izaura Maria Vieira Cayres Vallinoto, Cléa Nazaré Carneiro Bichara, Isabella Pinheiro Costa do Amaral, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Journal: Vaccines (Basel)

PubMed ID: 34696277

Doi: 10.3390/vaccines9101169

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Surface-Tethered Planar Membranes Containing the β-Barrel Assembly Machinery: a platform for Investigating Bacterial Outer Membrane Protein Folding

Authors: Stephen C L Hall, Luke A Clifton, Pooja Sridhar, David J Hardy, Peter Wotherspoon, Jack Wright, James Whitehouse, Nadisha Gamage, Claire S Laxton, Caitlin Hatton, Gareth W Hughes, Mark Jeeves, Timothy J Knowles

Journal: Biophys J

PubMed ID: 34757080

Doi: 10.1016/j.bpj.2021.10.033

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Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O Burzio, Verónica A Burzio

Journal: Biol Res

PubMed ID: 34666824

Doi: 10.1186/s40659-021-00356-0

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Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Authors: Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu, Banumathi Sankaran, Mary K Estes, B V Venkataram Prasad, James E Crowe

Journal: Nat Commun

PubMed ID: 34650069

Doi: 10.1038/s41467-021-26418-1

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Biodegradation of 4-hydroxybenzoic acid by Acinetobacter johnsonii FZ-5 and Klebsiella oxytoca FZ-8 under anaerobic conditions

Authors: Peng Lu, Huiying Huang, Yixiao Sun, Mengyao Qiang, Yan Zhu, Mengjiao Cao, Xue Peng, Bo Yuan, Zhaozhong Feng

Journal: Biodegradation

PubMed ID: 34609628

Doi: 10.1007/s10532-021-09963-w

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Corrigendum: Upregulated LINC01667 Expression Is Correlated With Poor Prognosis in Hepatocellular Carcinoma

Authors: Kainan Zhang, Hui Liu, Mengsi Yu, Hui Zhao, Ning Yang, Xiaojuan Bi, Li Sun, Renyong Lin, Guodong Lü

Journal: Front Oncol

PubMed ID: 34722323

Doi: 10.3389/fonc.2021.785394

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Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Based on the CRISPR-Cas12a System

Authors: Hui Qian, Wei Wei, Xin-Ai Chen, Xiao-Ting Mo, Mei Ge, Qing-Wei Zhao, Yong-Quan Li

Journal: ACS Synth Biol

PubMed ID: 34628852

Doi: 10.1021/acssynbio.1c00317

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Development of Neutralizing Multimeric Nanobody Constructs Directed against IL-13: From Immunization to Lead Optimization

Authors: Philippe J-L Y Gevenois, Pieter De Pauw, Steve Schoonooghe, Cédric Delporte, Thami Sebti, Karim Amighi, Serge Muyldermans, Nathalie Wauthoz

Journal: J Immunol

PubMed ID: 34645688

Doi: 10.4049/jimmunol.2100250

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Development of Rapid and Visual Nucleic Acid Detection Methods towards Four Serotypes of Human Adenovirus Species B Based on RPA-LF Test

Authors: Yong Qi, Wei Li, Xiaoling Li, Wanpeng Shen, Jinhai Zhang, Jiameng Li, Ruichen Lv, Nianhong Lu, Liqiang Zong, Susu Zhuang, Qiyuan Gui, Dongming Zhou, Jing Li, Yingjia Xu, Hongbing Shen, Yuexi Li

Journal: Biomed Res Int

PubMed ID: 34646888

Doi: 10.1155/2021/9957747

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Antigenicity and immunogenicity of recombinant proteins comprising African swine fever virus proteins p30 and p54 fused to a cell-penetrating peptide

Authors: Guanglei Zhang, Wei Liu, Zhan Gao, Sicheng Yang, Guangqing Zhou, Yanyan Chang, Yunyun Ma, Xiaxia Liang, Junjun Shao, Huiyun Chang

Journal: Int Immunopharmacol

PubMed ID: 34715492

Doi: 10.1016/j.intimp.2021.108251

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Authors: J J David Ho, Tyler A Cunningham, Paola Manara, Caroline A Coughlin, Artavazd Arumov, Evan R Roberts, Ashanti Osteen, Preet Kumar, Daniel Bilbao, Jonathan R Krieger, Stephen Lee, Jonathan H Schatz

Journal: Cell Rep

PubMed ID: 34644561

Doi: 10.1016/j.celrep.2021.109806

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Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus)

Authors: Ting Liu, Ti-Lin Yi, Dai-Qin Yang, Ya-Xiong Tao

Journal: Gen Comp Endocrinol

PubMed ID: 34653433

Doi: 10.1016/j.ygcen.2021.113928

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Aquaglyceroporins and orthodox aquaporins in human adipocytes

Authors: Peng Huang, Jesper S Hansen, Karim H Saba, Anna Bergman, Florentina Negoita, Pontus Gourdon, Anna Hagström-Andersson, Karin Lindkvist-Petersson

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34627746

Doi: 10.1016/j.bbamem.2021.183795

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Characterization of SARS-CoV-2 Variants N501YV1 and N501YV2 Spike on Viral Infectivity

Authors: Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, F Xiao-Feng Qin

Journal: Front Cell Infect Microbiol

PubMed ID: 34722330

Doi: 10.3389/fcimb.2021.720357

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Authors: Nina Svensen, Susan Wyllie, David W Gray, Manu De Rycker

Journal: PLoS Negl Trop Dis

PubMed ID: 34634052

Doi: 10.1371/journal.pntd.0009870

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