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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

Authors: Sanket S Ponia, Shelly J Robertson, Kristin L McNally, Gayatri Subramanian, Gail L Sturdevant, Matthew Lewis, Forrest Jessop, Catherine Kendall, Dylan Gallegos, Arielle Hay, Cindi Schwartz, Rebecca Rosenke, Greg Saturday, Catherine M Bosio, Craig Martens, Sonja M Best

Journal: Cell Rep

PubMed ID: 34706234

Doi: 10.1016/j.celrep.2021.109888

Products & Services: Mammalian Expression

Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis

Authors: Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim

Journal: Front Immunol

PubMed ID: 34691014

Doi: 10.3389/fimmu.2021.646316

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The S Protein of Group B Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome

Authors: Anaamika Campeau, Satoshi Uchiyama, Concepcion Sanchez, Consuelo Sauceda, Victor Nizet, David J Gonzalez

Journal: Front Microbiol

PubMed ID: 34721327

Doi: 10.3389/fmicb.2021.729308

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Homocysteine Inhibits Pro-Insulin Receptor Cleavage and Causes Insulin Resistance Via Protein Cysteine-Homocysteinylation

Authors: Xuan Zhang, Yuan-Yuan Qu, Lian Liu, Ya-Nan Qiao, Hao-Ran Geng, Yan Lin, Wei Xu, Jing Cao, Jian-Yuan Zhao

Journal: Cell Rep

PubMed ID: 34644569

Doi: 10.2139/ssrn.3830772

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Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang

Journal: Viruses

PubMed ID: 34834981

Doi: 10.3390/v13112175

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Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns

Authors: Stefan Hümmer, Sonia Borao, Angel Guerra-Moreno, Luca Cozzuto, Elena Hidalgo, José Ayté

Journal: Cell Rep

PubMed ID: 34706246

Doi: 10.1016/j.celrep.2021.109893

Products & Services: PCR Cloning and Subcloning

The expression, localisation and interactome of pigeon CRY2

Authors: Spencer D Balay, Tobias Hochstoeger, Alexandra Vilceanu, E Pascal Malkemper, William Snider, Gerhard Dürnberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C Nordmann, Lyubov Ushakova, Simon Nimpf, David A Keays

Journal: Sci Rep

PubMed ID: 34645873

Doi: 10.1038/s41598-021-99207-x

Products & Services: PCR Cloning and Subcloning

Newcastle Disease Virus Vectored Chicken Infectious Anaemia Vaccine Induces Robust Immune Response in Chickens

Authors: Madhan Mohan Chellappa, Sohini Dey, Dinesh Chandra Pathak, Asmita Singh, Narayan Ramamurthy, Saravanan Ramakrishnan, Asok Kumar Mariappan, Kuldeep Dhama, Vikram N Vakharia

Journal: Viruses

PubMed ID: 34696415

Doi: 10.3390/v13101985

Products & Services: ORF cDNA Clones/MolecularCloud

Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Authors: Andreas Greinacher, Kathleen Selleng, Julia Mayerle, Raghavendra Palankar, Jan Wesche, Sven Reiche, Andrea Aebischer, Theodore E Warkentin, Maximilian Muenchhoff, Johannes C Hellmuth, Oliver T Keppler, Daniel Duerschmied, Achim Lother, Siegbert Rieg, Meinrad Paul Gawaz, Karin Anne Lydia Mueller, Christian S Scheer, Matthias Napp, Klaus Hahnenkamp, Guglielmo Lucchese, Antje Vogelgesang, Agnes Flöel, Piero Lovreglio, Angela Stufano, Rolf Marschalek, Thomas Thiele

Journal: Blood

PubMed ID: 34280256

Doi: 10.1182/blood.2021012938

Products & Services: Mutant Libraries

The Sigma-1 receptor is an ER-localized type II membrane protein

Authors: Neeraj Sharma, Chaitanya Patel, Marina Shenkman, Amit Kessel, Nir Ben-Tal, Gerardo Z Lederkremer

Journal: J Biol Chem

PubMed ID: 34648767

Doi: 10.1016/j.jbc.2021.101299

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Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure

Authors: Wai Shun Mak, Tsz Ming Tsang, Tsz Yin Chan, Georgi L Lukov

Journal: Proteomes

PubMed ID: 34698247

Doi: 10.3390/proteomes9040040

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A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells

Authors: Thomas Welte, Junhua Mai, Zhe Zhang, Shaohui Tian, Guodong Zhang, Yitian Xu, Licheng Zhang, Shu-Shia Chen, Tian Wang, Haifa Shen

Journal: iScience

PubMed ID: 34825135

Doi: 10.1016/j.isci.2021.103349

Products & Services: DNA Sequencing

Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom

Authors: Sherin Kaul, L Sai Keerthana, Pankaj Kumar, Komal Birader, Yathirajarao Tammineni, Deepali Rawat, Pankaj Suman

Journal: PLoS Negl Trop Dis

PubMed ID: 34634067

Doi: 10.1371/journal.pntd.0009841

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The periplasmic expression and purification of AA15 lytic polysaccharide monooxygenases from insect species in Escherichia coli

Authors: João Paulo L Franco Cairo, Dnane V Almeida, André Damasio, Wanius Garcia, Fabio M Squina

Journal: Protein Expr Purif

PubMed ID: 34655732

Doi: 10.1016/j.pep.2021.105994

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Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in and

Authors: Haley S Ball, Misgina B Girma, Mosufa Zainab, Iswarduth Soojhawon, Robin D Couch, Schroeder M Noble

Journal: ACS Infect Dis

PubMed ID: 34672535

Doi: 10.1021/acsinfecdis.1c00132

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Bacterial Quorum-Quenching Lactonase Hydrolyzes Fungal Mycotoxin and Reduces Pathogenicity of -Suggesting a Mechanism of Bacterial Antagonism

Authors: Shlomit Dor, Dov Prusky, Livnat Afriat-Jurnou

Journal: J Fungi (Basel)

PubMed ID: 34682247

Doi: 10.3390/jof7100826

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Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins

Authors: Tomomi Shionoya, Manish Singh, Misao Mizuno, Hideki Kandori, Yasuhisa Mizutani

Journal: Biochemistry

PubMed ID: 34601881

Doi: 10.1021/acs.biochem.1c00529

Products & Services: Codon Optimization

A Thermostable Cas12b from Leverages One-pot Detection of SARS-CoV-2 Variants of Concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: medrxiv

PubMed ID: 34704101

Doi: 10.1101/2021.10.15.21265066

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A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Authors: Shalom D Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin

Journal: Pharmaceutics

PubMed ID: 34683962

Doi: 10.3390/pharmaceutics13101669

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Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Authors: Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki

Journal: J Exp Med

PubMed ID: 34647971

Doi: 10.1084/jem.20211327

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Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Authors: Harriet P Lo, Ye-Wheen Lim, Zherui Xiong, Nick Martel, Charles Ferguson, Nicholas Ariotti, Jean Giacomotto, James Rae, Matthias Floetenmeyer, Shayli Varasteh Moradi, Ya Gao, Vikas A Tillu, Di Xia, Huang Wang, Samira Rahnama, Susan J Nixon, Michele Bastiani, Ryan D Day, Kelly A Smith, Nathan J Palpant, Wayne A Johnston, Kirill Alexandrov, Brett M Collins, Thomas E Hall, Robert G Parton

Journal: J Cell Biol

PubMed ID: 34633413

Doi: 10.1083/jcb.201905065

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Profiling sirtuin activity using Copper-free click chemistry

Authors: Alyson M Curry, Ian Cohen, Song Zheng, Jessica Wohlfahrt, Dawanna S White, Dickson Donu, Yana Cen

Journal: Bioorg Chem

PubMed ID: 34655842

Doi: 10.1016/j.bioorg.2021.105413

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T cells promote metastasis by regulating extracellular matrix remodeling following chemotherapy

Authors: Jozafina Haj-Shomaly, Avital Vorontsova, Tamar Barenholz-Cohen, Oshrat Levi-Galibov, Mahesh Devarasetty, Michael Timaner, Ziv Raviv, Tim J Cooper, Shay Soker, Peleg Hasson, Daphne Weihs, Ruth Scherz-Shouval, Yuval Shaked

Journal: Cancer Res

PubMed ID: 34666995

Doi: 10.1158/0008-5472.CAN-21-1012

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Label-Free Colorimetric Method for Detection of by Trimming the G-Quadruplex DNAzyme with CRISPR/Cas12a

Authors: Xueyun Chen, Liu Wang, Fang He, Ganghui Chen, Linlin Bai, Kaiyu He, Fang Zhang, Xiahong Xu

Journal: Anal Chem

PubMed ID: 34645259

Doi: 10.1021/acs.analchem.1c03468

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Exosome-mediated delivery of inflammation-responsive mRNA for controlled atherosclerosis treatment

Authors: Te Bu, Zhelong Li, Ying Hou, Wenqi Sun, Rongxin Zhang, Lianbi Zhao, Mengying Wei, Guodong Yang, Lijun Yuan

Journal: Theranostics

PubMed ID: 34815799

Doi: 10.7150/thno.64229

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21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules

Authors: Alexander Hellesen, Sigrid Aslaksen, Lars Breivik, Ellen Christine Røyrvik, Øyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne Bøe Wolff, Eystein Sverre Husebye, Eirik Bratland

Journal: Front Immunol

PubMed ID: 34721410

Doi: 10.3389/fimmu.2021.742848

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A comparative study of mesenchymal stem cells cultured as cell-only aggregates and in encapsulated hydrogels

Authors: Fiona R Passanha, David B Gomes, Justyna Piotrowska, Lorenzo Moroni, Matthew B Baker, Vanessa L S LaPointe

Journal: J Tissue Eng Regen Med

PubMed ID: 34655456

Doi: 10.1002/term.3257

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Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy

Authors: Feng Xie, Peng Su, Ting Pan, Xiaoxue Zhou, Heyu Li, Huizhe Huang, Aijun Wang, Fangwei Wang, Jun Huang, Haiyan Yan, Linghui Zeng, Long Zhang, Fangfang Zhou

Journal: Adv Mater

PubMed ID: 34665481

Doi: 10.1002/adma.202103471

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A BioBricks toolbox for metabolic engineering of the tetracenomycin pathway

Authors: Jennifer T Nguyen, Kennedy K Riebschleger, Katelyn V Brown, Nina M Gorgijevska, S Eric Nybo

Journal: Biotechnol J.

PubMed ID: 34719127

Doi: doi.org/10.1002/biot.202100371

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Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR

Authors: Christopher Szeto, Andrea T Nguyen, Christian A Lobos, Demetra S M Chatzileontiadou, Dhilshan Jayasinghe, Emma J Grant, Alan Riboldi-Tunnicliffe, Corey Smith, Stephanie Gras

Journal: Cells

PubMed ID: 34685626

Doi: 10.3390/cells10102646

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Evaluation of the correlation between the access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test

Authors: Yutaro Kitagawa, Kazuo Imai, Masaru Matsuoka, Ai Fukada, Katsumi Kubota, Momoko Sato, Tomohito Takada, Sakiko Noguchi, Norihito Tarumoto, Shigefumi Maesaki, Shinichi Takeuchi, Takuya Maeda

Journal: J Med Virol

PubMed ID: 34524695

Doi: 10.1002/jmv.27338

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AuNPs- Aβ-Ni-HRP sandwich assay: A new sensitive colorimetric method for the detection of Aβ

Authors: Zeeshan A Khan, Seungkyung Park

Journal: Talanta

PubMed ID: 34736673

Doi: 10.1016/j.talanta.2021.122946

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TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Interaction With SYK in Experimental Subarachnoid Hemorrhage

Authors: Xinyan Wu, Hanhai Zeng, Chaoran Xu, Huaijun Chen, Linfeng Fan, Hang Zhou, Qian Yu, Xiongjie Fu, Yucong Peng, Feng Yan, Xiaobo Yu, Gao Chen

Journal: Front Immunol

PubMed ID: 34721438

Doi: 10.3389/fimmu.2021.766178

Products & Services: Recombinant Antibody Expression

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Authors: Xianglei Liu, Doncho Zhelev, Cynthia Adams, Chuan Chen, John W Mellors, Dimiter S Dimitrov

Journal: Transl Oncol

PubMed ID: 34601396

Doi: 10.1016/j.tranon.2021.101232

Products & Services: Protein and Antibody Isolation

Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Authors: Irani Alves Ferreira-Bravo, Jeffrey J DeStefano

Journal: Viruses

PubMed ID: 34696413

Doi: 10.3390/v13101983

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Low-Field NMR Analysis of Chicken Patties Prepared with Woody Breast Meat and Implications to Meat Quality

Authors: Xiao Sun, Jinjie You, Yan Dong, Ligen Xu, Clay J Maynard, Casey M Owens

Journal: Foods

PubMed ID: 34681548

Doi: 10.3390/foods10102499

Products & Services: Protein and Antibody Isolation

Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations

Authors: Rafat Zrieq, Iqrar Ahmad, Mejdi Snoussi, Emira Noumi, Marcello Iriti, Fahad D Algahtani, Harun Patel, Mohd Saeed, Munazzah Tasleem, Shadi Sulaiman, Kaïss Aouadi, Adel Kadri

Journal: Int J Mol Sci

PubMed ID: 34639036

Doi: 10.3390/ijms221910693

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PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

Authors: Holly Fowle, Ziran Zhao, Qifang Xu, Jason S Wasserman, Xinru Wang, Mary Adeyemi, Felicity Feiser, Alison N Kurimchak, Diba Atar, Brennan C McEwan, Arminja N Kettenbach, Rebecca Page, Wolfgang Peti, Roland L Dunbrack, Xavier Graña

Journal: Elife

PubMed ID: 34661528

Doi: 10.7554/eLife.63181

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miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis

Authors: Diego López-Márquez, Ángel Del-Espino, Nieves López-Pagán, Edgar A Rodríguez-Negrete, Ignacio Rubio-Somoza, Javier Ruiz-Albert, Eduardo R Bejarano, Carmen R Beuzón

Journal: J Exp Bot

PubMed ID: 34329403

Doi: 10.1093/jxb/erab354

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Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells

Authors: Kosuke Yokobori, Yuki Kawasaki, Yoshitaka Sekine, Sumihito Nobusawa, Toshiyuki Sakaki, Masahiko Negishi, Satoru Kakizaki

Journal: Biochem Pharmacol

PubMed ID: 34715066

Doi: 10.1016/j.bcp.2021.114794

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Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Authors: Brion W Murray, Evan Rogers, Dayong Zhai, Wei Deng, Xi Chen, Paul A Sprengeler, Xin Zhang, Armin Graber, Siegfried H Reich, Shanna Stopatschinskaja, Benjamin Solomon, Benjamin Besse, Alexander Drilon

Journal: Mol Cancer Ther

PubMed ID: 34625502

Doi: 10.1158/1535-7163.MCT-21-0632

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MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling

Authors: Jianping Cao, Meng Jiang, Huafeng Ren, Kai Xu

Journal: Mol Med Rep

PubMed ID: 34676879

Doi: 10.3892/mmr.2021.12505

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KDM5B protein expressed in viable and fertile ΔARID mice exhibit no demethylase activity

Authors: Shirin Jamshidi, Steven Catchpole, Jie Chen, Chi Wai Eric So, Joy Burchell, Khondaker Miraz Rahman, Joyce Taylor-Papadimitriou

Journal: Int J Oncol

PubMed ID: 34713299

Doi: 10.3892/ijo.2021.5276

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Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability

Authors: Simona Graziano, Nuria Coll-Bonfill, Barbara Teodoro-Castro, Sahiti Kuppa, Jessica Jackson, Elena Shashkova, Urvashi Mahajan, Alessandro Vindigni, Edwin Antony, Susana Gonzalo

Journal: J Biol Chem

PubMed ID: 34648766

Doi: 10.1016/j.jbc.2021.101301

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Influence of Primary Structure on Fragmentation of Native-Like Proteins by Ultraviolet Photodissociation

Authors: Luis A Macias, Sarah N Sipe, Inês C Santos, Aarti Bashyal, M Rachel Mehaffey, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 34714071

Doi: 10.1021/jasms.1c00269

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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

Authors: Keren Isaev, Lingyan Jiang, Shuai Wu, Christian A Lee, Valérie Watters, Victoire Fort, Ricky Tsai, Fiona J Coutinho, Samer M I Hussein, Jie Zhang, Jinsong Wu, Peter B Dirks, Daniel Schramek, Jüri Reimand

Journal: Cell Rep

PubMed ID: 34686327

Doi: 10.1016/j.celrep.2021.109873

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Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost

Authors: Tamara Davidovic, Judith Schimpf, Armin Abbassi-Nik, Richard Stockinger, Hannelore Sprenger-Mähr, Karl Lhotta, Emanuel Zitt

Journal: Kidney Int

PubMed ID: 34656642

Doi: 10.1016/j.kint.2021.10.006

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Authors: Marumi Ohno, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md Abdul Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida, Hirofumi Sawa, Masashi Shingai

Journal: Viruses

PubMed ID: 34834944

Doi: 10.3390/v13112137

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Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

Authors: Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Journal: iScience

PubMed ID: 34825148

Doi: 10.1016/j.isci.2021.103396

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MYB70 modulates seed germination and root system development in

Authors: Jinpeng Wan, Ruling Wang, Ping Zhang, Liangliang Sun, Qiong Ju, Haodong Huang, Shiyou Lü, Lam-Son Tran, Jin Xu

Journal: iScience

PubMed ID: 34746697

Doi: 10.1016/j.isci.2021.103228

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Structure-Function Analysis of Resistance to Bamlanivimab by SARS-CoV-2 Variants Kappa, Delta, and Lambda

Authors: Shufeng Liu, Tien Huynh, Charles B Stauft, Tony T Wang, Binquan Luan

Journal: J Chem Inf Model

PubMed ID: 34648284

Doi: 10.1021/acs.jcim.1c01058

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Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia

Authors: Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palanikumar, Nair Reeshma Radhakrishnan, Mohammed Yasar M, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews

Journal: Blood Adv

PubMed ID: 34625794

Doi: 10.1182/bloodadvances.2021005300

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Effect of Cotton Leafroll Dwarf Virus on Physiological Processes and Yield of Individual Cotton Plants

Authors: Ved Parkash, Divya Bhanu Sharma, John Snider, Sudeep Bag, Phillip Roberts, Afsha Tabassum, Dalton West, Sameer Khanal, Nelson Suassuna, Peng Chee

Journal: Front Plant Sci

PubMed ID: 34659302

Doi: 10.3389/fpls.2021.734386

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NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Authors: Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J Ulevitch, Jiahuai Han

Journal: Sci Adv

PubMed ID: 34678072

Doi: 10.1126/sciadv.abi9471

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An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Authors: Martijn A Langereis, Irina C Albulescu, Judith Stammen-Vogelzangs, Morindy Lambregts, Ken Stachura, Suzan Miller, Angela M Bosco-Lauth, Airn E Hartwig, Stephanie M Porter, Michelle Allen, Mark Mogler, Frank J M van Kuppeveld, Berend-Jan Bosch, Paul Vermeij, Ad de Groof, Richard A Bowen, Randy Davis, Zach Xu, Ian Tarpey

Journal: npj Vaccines

PubMed ID: 34671047

Doi: 10.1038/s41541-021-00390-9

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Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

Authors: Katelyn Mika, Mirna Marinić, Manvendra Singh, Joanne Muter, Jan Joris Brosens, Vincent J Lynch

Journal: Elife

PubMed ID: 34623259

Doi: 10.7554/eLife.69584

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The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

Authors: Kevin J Forsberg, Danica T Schmidtke, Rachel Werther, Ruben V Uribe, Deanna Hausman, Morten O A Sommer, Barry L Stoddard, Brett K Kaiser, Harmit S Malik

Journal: PLoS Biol

PubMed ID: 34644300

Doi: 10.1371/journal.pbio.3001428

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Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation

Authors: Krishna K Sarangapani, Lori B Koch, Christian R Nelson, Charles L Asbury, Sue Biggins

Journal: J Cell Biol

PubMed ID: 34647959

Doi: 10.1083/jcb.202106130

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Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

Authors: Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu

Journal: Front Cell Dev Biol

PubMed ID: 34778244

Doi: 10.3389/fcell.2021.666025

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Anastrozole regulates fatty acid synthase in breast cancer

Authors: Junmei Cairns, James N Ingle, Krishna R Kalari, Matthew P Goetz, Richard M Weinshilboum, Huanyao Gao, Hu Li, Mehrab Ghanat Bari, Liewei Wang

Journal: Mol Cancer Ther

PubMed ID: 34667110

Doi: 10.1158/1535-7163.MCT-21-0509

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CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Authors: Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu

Journal: Theranostics

PubMed ID: 34815788

Doi: 10.7150/thno.62187

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Aptamer-modified biosensors to visualize neurotransmitter flux

Authors: Charlotte Moraldo, Emilie Vuille-Dit-Bille, Bajramshahe Shkodra, Tom Kloter, Nako Nakatsuka

Journal: J Neurosci Methods

PubMed ID: 34653500

Doi: 10.1016/j.jneumeth.2021.109386

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Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Authors: Young-Jun Park, Anna De Marco, Tyler N Starr, Zhuoming Liu, Dora Pinto, Alexandra C Walls, Fabrizia Zatta, Samantha K Zepeda, John Bowen, Kaitlin S Sprouse, Anshu Joshi, Martina Giurdanella, Barbara Guarino, Julia Noack, Rana Abdelnabi, Shi-Yan Caroline Foo, Florian A Lempp, Fabio Benigni, Gyorgy Snell, Johan Neyts, Sean Pj Whelan, Herbert W Virgin, Jesse D Bloom, Davide Corti, Matteo Samuele Pizzuto, David Veesler

Journal: biorxiv

PubMed ID: 34671770

Doi: 10.1101/2021.10.13.464254

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Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Authors: Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann

Journal: Elife

PubMed ID: 34713805

Doi: 10.7554/eLife.69832

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Combining an optimized mRNA template with a double purification process allows strong expression of transcribed mRNA

Authors: Sergio Linares-Fernández, Julien Moreno, Elise Lambert, Perrine Mercier-Gouy, Laetitia Vachez, Bernard Verrier, Jean-Yves Exposito

Journal: Mol Ther Nucleic Acids

PubMed ID: 34692232

Doi: 10.1016/j.omtn.2021.10.007

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Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Authors: Naiyan Lu, Xinhe Wang, Wentao Shi, Lu Bian, Xuan Zhang, Guofeng Yang, Xue Tang, Jun Wang, Yin Zou, Yuyan Weng

Journal: Nanoscale Res Lett

PubMed ID: 34637014

Doi: 10.1186/s11671-021-03610-2

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In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain

Authors: Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Linnea Molander, Johannes Fuchs, Ruth H Palmer

Journal: J Mol Biol

PubMed ID: 34624297

Doi: 10.1016/j.jmb.2021.167282

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Epitopes prediction for microcystin-LR by molecular docking

Authors: Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34717216

Doi: 10.1016/j.ecoenv.2021.112925

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Quantifying oxidation of cellulose-associated glucuronoxylan by two lytic polysaccharide monooxygenases from

Authors: Olav A Hegnar, Heidi Østby, Dejan M Petrović, Lisbeth Olsson, Anikó Várnai, Vincent G H Eijsink

Journal: Appl Environ Microbiol

PubMed ID: 34613755

Doi: 10.1128/AEM.01652-21

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Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Authors: Frank Kozielski, Céleste Sele, Vladimir O Talibov, Jiaqi Lou, Danni Dong, Qian Wang, Xinyue Shi, Maria Nyblom, Annika Rogstam, Tobias Krojer, Zoë Fisher, Wolfgang Knecht

Journal: RSC Chem Biol

PubMed ID: 35128408

Doi: 10.1039/d1cb00135c

Products & Services: Bacterial Expression

Effects of Distal Mutations on Ligand-Binding Affinity in Dihydrofolate Reductase

Authors: Chen-Hua Huang, Yun-Wen Chen, Tsun-Tsao Huang, Ya-Ting Kao

Journal: ACS Omega

PubMed ID: 34660967

Doi: 10.1021/acsomega.1c02995

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The Development of Dual Vaccines against Lumpy Skin Disease (LSD) and Bovine Ephemeral Fever (BEF)

Authors: Nicola Douglass, Ruzaiq Omar, Henry Munyanduki, Akiko Suzuki, Warren de Moor, Paidamwoyo Mutowembwa, Alri Pretorius, Tshifhiwa Nefefe, Antoinette van Schalkwyk, Pravesh Kara, Livio Heath, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34835146

Doi: 10.3390/vaccines9111215

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Characteristics of Two Crustins from in Hydrothermal Vents

Authors: Lu-Lu Guo, Shao-Lu Wang, Fang-Chao Zhu, Feng Xue, Li-Sheng He

Journal: Mar Drugs

PubMed ID: 34822471

Doi: 10.3390/md19110600

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Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 2647 macrophages

Authors: Shan Hong, Vermont P Dia, Qixin Zhong

Journal: Int J Biol Macromol

PubMed ID: 34717976

Doi: 10.1016/j.ijbiomac.2021.10.153

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Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Authors: Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Journal: Front Immunol

PubMed ID: 34745083

Doi: 10.3389/fimmu.2021.670338

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Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

Authors: Anahita Nejatfard, Nicholas Wauer, Satarupa Bhaduri, Adam Conn, Saroj Gourkanti, Narinderbir Singh, Tiffany Kuo, Rachel Kandel, Rommie E Amaro, Sonya E Neal

Journal: Cell Rep

PubMed ID: 34686332

Doi: 10.1016/j.celrep.2021.109840

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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Authors: Ning Tsao, Joshua R Brickner, Rebecca Rodell, Adit Ganguly, Matthew Wood, Clement Oyeniran, Tanveer Ahmad, Hua Sun, Albino Bacolla, Lisheng Zhang, Valentina Lukinović, Jennifer M Soll, Brittany A Townley, Alexandre G Casanova, John A Tainer, Chuan He, Alessandro Vindigni, Nicolas Reynoird, Nima Mosammaparast

Journal: Mol Cell

PubMed ID: 34686315

Doi: 10.1016/j.molcel.2021.09.024

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Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants in PDZ Domains Using Human PDZ Data

Authors: Haley A Wofford, Josh Myers-Dean, Brandon A Vogel, Kevin Alexander Estrada Alamo, Frederick A Longshore-Neate, Filip Jagodzinski, Jeanine F Amacher

Journal: Molecules

PubMed ID: 34641578

Doi: 10.3390/molecules26196034

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Ambient Temperature Stable, Scalable COVID-19 Polymer Particle Vaccines Induce Protective Immunity

Authors: Shuxiong Chen, Benjamin Evert, Adetayo Adeniyi, Mercè Salla-Martret, Linda H-L Lua, Victoria Ozberk, Manisha Pandey, Michael F Good, Andreas Suhrbier, Peter Halfmann, Yoshihiro Kawaoka, Bernd H A Rehm

Journal: Adv Healthc Mater

PubMed ID: 34716678

Doi: 10.1002/adhm.202102089

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Low-bias ncRNA libraries using ordered two-template relay: Serial template jumping by a modified retroelement reverse transcriptase

Authors: Heather E Upton, Lucas Ferguson, Morayma M Temoche-Diaz, Xiao-Man Liu, Sydney C Pimentel, Nicholas T Ingolia, Randy Schekman, Kathleen Collins

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34649994

Doi: 10.1073/pnas.2107900118

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Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility

Authors: Małgorzata Gutkowska, Magdalena Kaus-Drobek, Marta Hoffman-Sommer, Magdalena Małgorzata Pamuła, Anna Daria Leja, Małgorzata Perycz, Małgorzata Lichocka, Agnieszka Witek, Magdalena Wojtas, Michał Dadlez, Ewa Swiezewska, Liliana Surmacz

Journal: Plant J

PubMed ID: 34592024

Doi: 10.1111/tpj.15519

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The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

Authors: Ivo A Hendriks, Sara C Buch-Larsen, Evgeniia Prokhorova, Jonas D Elsborg, Alexandra K L F S Rebak, Kang Zhu, Dragana Ahel, Claudia Lukas, Ivan Ahel, Michael L Nielsen

Journal: Nat Commun

PubMed ID: 34625544

Doi: 10.1038/s41467-021-26172-4

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A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG

Authors: María-Natalia Lisa, Adrià Sogues, Nathalie Barilone, Meike Baumgart, Magdalena Gil, Martín Graña, Rosario Durán, Ricardo M Biondi, Marco Bellinzoni, Michael Bott, Pedro M Alzari

Journal: MBio

PubMed ID: 34607462

Doi: 10.1128/mBio.01717-21

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Molecular switches regulating the potency and immune evasiveness of SARS-CoV-2 spike protein

Authors: Yushun Wan, Linfen Huang, Xiujuan Zhang, Jian Shang, Stanley Perlman, Lanying Du, Fang Li

Journal: Res Sq

PubMed ID: 34611654

Doi: 10.21203/rs.3.rs-736159/v2

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Smart exosomes with lymph node homing and immune-amplifying capacities for enhanced immunotherapy of metastatic breast cancer

Authors: Panpan Ji, Zheng Yang, Hua Li, Mengying Wei, Guodong Yang, Helin Xing, Qiuyun Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 34760340

Doi: 10.1016/j.omtn.2021.10.009

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p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR

Authors: Sinem Usluer, Emil Spreitzer, Benjamin Bourgeois, Tobias Madl

Journal: Int J Mol Sci

PubMed ID: 34768862

Doi: 10.3390/ijms222111431

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A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiation

Authors: Pengjie Hu, Hao Ding, Lan Shen, Guang-Jun He, Huimin Liu, Xiuyun Tian, Changyu Tao, Xiangzheng Bai, Jingnan Liang, Cheng Jin, Xinping Xu, Ence Yang, Linqi Wang

Journal: PLoS Genet

PubMed ID: 34624015

Doi: 10.1371/journal.pgen.1009817

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F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis

Authors: Christopher S Campomizzi, George E Ghanatios, D Fernando Estrada

Journal: J Biol Chem

PubMed ID: 34634307

Doi: 10.1016/j.jbc.2021.101287

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Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants

Authors: Nabangshu Sharma, Ivanhoe K H Leung

Journal: Front Chem

PubMed ID: 34746090

Doi: 10.3389/fchem.2021.711345

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Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression

Authors: Gloria Gamiz-Arco, Valeria A Risso, Eric A Gaucher, Jose A Gavira, Athi N Naganathan, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz

Journal: J Mol Biol

PubMed ID: 34687715

Doi: 10.1016/j.jmb.2021.167321

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Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring

Authors: Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok H De Vos, Jean-Pierre Timmermans, Shunqing Xu, Yaohui Tang, Xia Sheng

Journal: Adv Sci (Weinh)

PubMed ID: 34713618

Doi: 10.1002/advs.202102686

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Non-canonical activation of the ER stress sensor ATF6 by effectors

Authors: Nnejiuwa U Ibe, Advait Subramanian, Shaeri Mukherjee

Journal: Life Sci Alliance

PubMed ID: 34635501

Doi: 10.26508/lsa.202101247

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Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Authors: Jiajia Wang, Jiaying Wang, Wenxiang Hong, Lulu Zhang, Liqian Song, Qi Shi, Yanfei Shao, Guifeng Hao, Chunyan Fang, Yueping Qiu, Lijun Yang, Zhaoxu Yang, Jincheng Wang, Ji Cao, Bo Yang, Qiaojun He, Qinjie Weng

Journal: Nat Commun

PubMed ID: 34707127

Doi: 10.1038/s41467-021-26477-4

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Mdivi-1 Modulates Macrophage/Microglial Polarization in Mice with EAE via the Inhibition of the TLR2/4-GSK3β-NF-κB Inflammatory Signaling Axis

Authors: Xiaoqin Liu, Xiaojuan Zhang, Xiaojie Niu, Peijun Zhang, Qing Wang, Xiuhua Xue, Guobin Song, Jiezhong Yu, Guoping Xi, Lijuan Song, Yanhua Li, Cungen Ma

Journal: Mol Neurobiol

PubMed ID: 34618332

Doi: 10.1007/s12035-021-02552-1

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Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants

Authors: Haitao Liu, Chenliang Zhou, Jiao An, Yujiao Song, Pin Yu, Jiadai Li, Chenjian Gu, Dongdong Hu, Yuanxiang Jiang, Lingli Zhang, Chuanqi Huang, Chao Zhang, Yunqi Yang, Qianjun Zhu, Dekui Wang, Yuqiang Liu, Chenyang Miao, Xiayao Cao, Longfei Ding, Yuanfei Zhu, Hua Zhu, Linlin Bao, Lingyun Zhou, Huan Yan, Jiang Fan, Jianqing Xu, Zhongyu Hu, Youhua Xie, Jiangning Liu, Ge Liu

Journal: Vaccine

PubMed ID: 34750014

Doi: 10.1016/j.vaccine.2021.10.066

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SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation

Authors: Cristina Mir, Yoelsis Garcia-Mayea, Laia Garcia, Pol Herrero, Nuria Canela, Rocío Tabernero, Juan Lorente, Josep Castellvi, Eva Allonca, Juana García-Pedrero, Juan Pablo Rodrigo, Ángel Carracedo, Matilde Esther LLeonart

Journal: Cancers (Basel)

PubMed ID: 34638436

Doi: 10.3390/cancers13194952

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Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1

Authors: Dongkook Min, Jaemin Byun, Eun-Joon Lee, Abdul A Khan, Christina Liu, Oliver Loudig, Wei Hu, Yong Zhao, Meenhard Herlyn, Benjamin Tycko, Phillip A Cole, Byungwoo Ryu

Journal: Mol Cancer Res

PubMed ID: 34610961

Doi: 10.1158/1541-7786.MCR-21-0289

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The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein

Authors: Yunpeng Sun, Houfang Long, Wencheng Xia, Kun Wang, Xia Zhang, Bo Sun, Qin Cao, Yaoyang Zhang, Bin Dai, Dan Li, Cong Liu

Journal: Nat Commun

PubMed ID: 34716315

Doi: 10.1038/s41467-021-26433-2

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Immune Responses to Orally Administered Recombinant Expressing Multi-Epitope Proteins Targeting M Cells of Foot-and-Mouth Disease Virus

Authors: Fudong Zhang, Zhongwang Zhang, Xian Li, Jiahao Li, Jianliang Lv, Zhongyuan Ma, Li Pan