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A novel fluorescent aptasensor based on exonuclease-assisted triple recycling amplification for sensitive and label-free detection of aflatoxin B1

Authors: Hao Wu, Hongyong Wang, Jun Wu, Guoqing Han, Yaling Liu, Pei Zou

Journal: J Hazard Mater.

PubMed ID: 33743380

Doi: 10.1016/j.jhazmat.2021.125584

Products & Services: Custom DNA/RNA Oligos

Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Authors: Yuan Jin, Qilin Meng, Bihui Zhang, Chen Xie, Xue Chen, Baoqing Tian, Jiakang Wang, Tsung-Chieh Shih, Yibo Zhang, Jieqiong Cao, Yiqi Yang, Size Chen, Xinyuan Guan, Xiaojia Chen, An Hong

Journal: Int J Biol Sci

PubMed ID: 34671193

Doi: 10.7150/ijbs.62571

Products & Services: DNA Sequencing

Helicase-AID: A novel molecular device for base editing at random genomic loci

Authors: Jie Wang, Dongdong Zhao, Ju Li, Muzi Hu, Xiuqing Xin, Marcus A Price, Qingyan Li, Li Liu, Siwei Li, Susan J Rosser, Chunzhi Zhang, Changhao Bi, Xueli Zhang

Journal: Metab Eng

PubMed ID: 34411701

Doi: 10.1016/j.ymben.2021.08.005

Products & Services: DNA Sequencing

Sclerotinia sclerotiorum Thioredoxin1 (SsTrx1) is required for pathogenicity and oxidative stress tolerance

Authors: Kusum Rana, Yijuan Ding, Surinder S Banga, Hongmei Liao, Siqi Zhao, Yang Yu, Wei Qian

Journal: Mol Plant Pathol

PubMed ID: 34459563

Doi: 10.1111/mpp.13127

Products & Services: Custom RNAi Services

Expression and characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for application in enhancing fatty acids flavor release for low-fat cheeses

Authors: Junxin Zhao, Maomao Ma, Xianghui Yan, Guohua Zhang, Jiaheng Xia, Guibing Zeng, Wenran Tian, Xianliang Bao, Zheling Zeng, Ping Yu, Deming Gong

Journal: Food Chem

PubMed ID: 34438173

Doi: 10.1016/j.foodchem.2021.130868

Products & Services: Codon Optimization

Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat

Authors: Elham Rezvannejad, Seyed Azim Mousavizadeh, Safa Lotfi, Najmeh Kargar

Journal: Anim Biotechnol

PubMed ID: 34370605

Doi: 10.1080/10495398.2021.1954935

Molecular Context of Dopa Influences Adhesion of Mussel-Inspired Peptides

Authors: George D Degen, Keila C Cunha, Zachary A Levine, J Herbert Waite, Joan-Emma Shea

Journal: J Phys Chem B

PubMed ID: 34459591

Doi: 10.1021/acs.jpcb.1c05218

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Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

Authors: Ning Wu, Zhi Li, Jing Wang, Lihua Geng, Yang Yue, Zhenzhen Deng, Qingchi Wang, Quanbin Zhang

Journal: Carbohydr Polym

PubMed ID: 34560978

Doi: 10.1016/j.carbpol.2021.118567

Products & Services: Recombinant Proteins

Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca levels

Authors: Ferdinand F Fatiga, Li-Jie Wang, Tian Hsu, Jenica Irish Capuno, Chi-Yu Fu

Journal: J Cell Biochem

PubMed ID: 34431132

Doi: 10.1002/jcb.30138

Products & Services: Catalog Antibody

Light-Responsive Dynamic Protein Hydrogels Based on LOVTRAP

Authors: Tianyu Duan, Qingyuan Bian, Hongbin Li

Journal: Langmuir

PubMed ID: 34396769

Doi: 10.1021/acs.langmuir.1c01699

Products & Services: Catalog Antibody

Merlin functions as a critical regulator in Staphylococcus aureus-induced osteomyelitis

Authors: Zubin Zhou, Yuanliang Chen, Hong Sung Min, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Xiaowei Yu

Journal: J Cell Physiol

PubMed ID: 34378805

Doi: 10.1002/jcp.30550

Products & Services: Custom DNA/RNA Oligos

Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution

Authors: Andreia M Silva, Elisa Lázaro-Ibáñez, Anders Gunnarsson, Aditya Dhande, George Daaboul, Ben Peacock, Xabier Osteikoetxea, Nikki Salmond, Kristina Pagh Friis, Olga Shatnyeva, Niek Dekker

Journal: J Extracell Vesicles

PubMed ID: 34377376

Doi: 10.1002/jev2.12130

Products & Services: Proteins, Expression, Isolation and Analysis

An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles

Authors: Tiffany R Frey, Ibukun A Akinyemi, Eric M Burton, Sumita Bhaduri-McIntosh, Michael T McIntosh

Journal: Front Microbiol

PubMed ID: 34434177

Doi: 10.3389/fmicb.2021.708404

Products & Services: Gene Synthesis

Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from

Authors: Zahra Najarzadeh, Janni Nielsen, Azad Farzadfard, Vita Sereikaite, Kristian Strømgaard, Rikke Louise Meyer, Daniel Erik Otzen

Journal: ACS Omega

PubMed ID: 34497891

Doi: 10.1021/acsomega.1c02333

Products & Services: Peptide Synthesis

() Could Inhibit the Proliferation of Nucleopolyhedrovirus through Promoting Apoptosis

Authors: Jie Wang, Lin-Bao Zhu, Yan Ma, Ying-Xue Liu, Hui-Hua Cao, Yu-Ling Wang, Xue Kong, Zhi-Hao Huang, Han-Dan Zhu, Yan-Xiang Wang, Shi-Huo Liu, Jia-Ping Xu

Journal: Insects

PubMed ID: 34442307

Doi: 10.3390/insects12080743

Products & Services: Recombinant Antibody Expression

Coleopteran-specific StaufenC functions like Loquacious-PD in dsRNA processing

Authors: Kyungbo Kim, Jinmo Koo, June-Sun Yoon, Subba Reddy Palli

Journal: RNA Biol

PubMed ID: 34376105

Doi: 10.1080/15476286.2021.1960687

Products & Services: Recombinant Antibody Expression

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano

Journal: Arthritis Res Ther

PubMed ID: 34344444

Doi: 10.1186/s13075-021-02555-2

Products & Services: Proteins, Expression, Isolation and Analysis

Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Authors: Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Grünewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A Slattery, Jakob von Engelhardt, Michael J Courtney, Andreas Reif

Journal: EBioMedicine

PubMed ID: 34455393

Doi: 10.1016/j.ebiom.2021.103565

Products & Services: Proteins, Expression, Isolation and Analysis

Refining the N-Termini of the SARS-CoV-2 Spike Protein and Its Discrete Receptor-Binding Domain

Authors: Robert A D'Ippolito, Matthew R Drew, Jennifer Mehalko, Kelly Snead, Vanessa Wall, Zoe Putman, Dominic Esposito, Caroline J DeHart

Journal: J Proteome Res

PubMed ID: 34379411

Doi: 10.1021/acs.jproteome.1c00349

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

Authors: Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar

Journal: Nat Struct Mol Biol

PubMed ID: 34373645

Doi: 10.1038/s41594-021-00635-0

Products & Services: Proteins, Expression, Isolation and Analysis

Tandem Mass Spectrometry as Strategy for the Selective Identification and Quantification of the Amyloid Precursor Protein Tyr682 Residue Phosphorylation Status in Human Blood Mononuclear Cells

Authors: Pierluigi Reveglia, Rosarita Nasso, Antonella Angiolillo, Lucia Lecce, Carmela Paolillo, Samantha De Tullio, Monica Gelzo, Alfonso Di Costanzo, Carmela Matrone, Gaetano Corso

Journal: Biomolecules

PubMed ID: 34572510

Doi: 10.3390/biom11091297

Products & Services: Peptide Synthesis

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

Authors: Shailesh K Shahi, Soham Ali, Camille M Jaime, Natalya V Guseva, Ashutosh K Mangalam

Journal: Immunohorizons

PubMed ID: 34380664

Doi: 10.4049/immunohorizons.2100024

Products & Services: Peptide Synthesis

CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

Authors: Sarah A Greaves, Avinash Ravindran, Radleigh G Santos, Lan Chen, Michael T Falta, Yang Wang, Angela M Mitchell, Shaikh M Atif, Douglas G Mack, Alex N Tinega, Lisa A Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P Fontenot

Journal: J Exp Med

PubMed ID: 34410304

Doi: 10.1084/jem.20210785

Products & Services: Peptide Library Services

Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families

Authors: Alfonso Méndez-Godoy, Daniel García-Montalvo, León P Martínez-Castilla, Nuria Sánchez-Puig

Journal: Mol Genet Genomics

PubMed ID: 34453201

Doi: 10.1007/s00438-021-01814-w

Products & Services: PCR Cloning and Subcloning

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

Authors: Toni Rendulić, João Alves, João Azevedo-Silva, Isabel Soares-Silva, Margarida Casal

Journal: Comput Struct Biotechnol J

PubMed ID: 34471488

Doi: 10.1016/j.csbj.2021.08.002

Products & Services: ORF cDNA Clones/MolecularCloud

Double-Stranded RNA-Degrading Enzymes Reduce the Efficiency of RNA Interference in

Authors: Jin-Zhi Chen, Ying-Xia Jiang, Miao-Wen Li, Jian-Wen Li, Ben-Hu Zha, Guang Yang

Journal: Insects

PubMed ID: 34442278

Doi: 10.3390/insects12080712

Products & Services: Monoclonal Antibody Services

Dynamic Changes in the Levels of Amyloid-β Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease

Authors: Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo

Journal: Front Mol Neurosci

PubMed ID: 34512259

Doi: 10.3389/fnmol.2021.723317

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Compound heterozygosis in AADC deficiency: A complex phenotype dissected through comparison among heterodimeric and homodimeric AADC proteins

Authors: Carmen Longo, Riccardo Montioli, Giovanni Bisello, Luana Palazzi, Mario Mastrangelo, Heiko Brennenstuhl, Patrizia Polverino de Laureto, Thomas Opladen, Vincenzo Leuzzi, Mariarita Bertoldi

Journal: Mol Genet Metab

PubMed ID: 34479793

Doi: 10.1016/j.ymgme.2021.08.011

Products & Services: Monoclonal Antibody Services

Generation and characterization of a humanized anti-IL-17A rabbit monoclonal antibody

Authors: Wei Chen, Yong Kong, Wang Li, Yi Zhou, Meijuan Wu, Tao Chen, Yiliang Wu, Huaiyao Qiao, Zhihua Qiu, Jiwan Qiu

Journal: Protein Expr Purif

PubMed ID: 34363980

Doi: 10.1016/j.pep.2021.105950

Products & Services: Mammalian Expression

Knockdown of miR-125b-5p inhibits the proliferation and invasion of gastric carcinoma cells by targeting RYBP

Authors: Fu-E Jin, Bo Xie, Hong-Zhen Xian, Ji-Hai Wang

Journal: Kaohsiung J Med Sci

PubMed ID: 34337862

Doi: 10.1002/kjm2.12425

Products & Services: GenParts™ DNA Fragments

Structure, Antigenic Properties, and Highly Efficient Assembly of PCV4 Capsid Protein

Authors: Dongliang Wang, Jinhui Mai, Bo Lei, Yingjie Zhang, Yi Yang, Naidong Wang

Journal: Front Vet Sci

PubMed ID: 34504886

Doi: 10.3389/fvets.2021.695466

Products & Services: Gene Synthesis

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Authors: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi

Journal: J Exp Clin Cancer Res

PubMed ID: 34364401

Doi: 10.1186/s13046-021-02049-8

Products & Services: GenCrispr Cas9 Genome Editing

Industry updates from the field of stem cell research and regenerative medicine in June 2021

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 34387128

Doi: 10.2217/rme-2021-0097

Products & Services: GenCrispr Cas9 Genome Editing

P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway

Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao

Journal: Cell Cycle

PubMed ID: 34382920

Doi: 10.1080/15384101.2021.1963910

Products & Services: DNA Sequencing

β-Amyloid fibrils catalyze neurotransmitter degradation

Authors: Elad Arad, Avigail Baruch Leshem, Hanna Rapaport, Raz Jelinek

Journal: Chem Catalysis

Doi: 10.1016/j.checat.2021.07.005

Products & Services: Peptide Synthesis

Identification of a peptide binding to cancer antigen Kita‐kyushu lung cancer antigen 1 from a phage‐display library

Authors: Xiaoxiao Yu, Jiayao Yan,Xiaotong Chen,Jia Wei,Lixia Yu,Fangcen Liu,Lin Li,Baorui Liu

Journal: Cancer Science

PubMed ID: 34387029

Doi: 10.1111/cas.15109

Products & Services: Antibody Services Peptide Synthesis

Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

Authors: Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu, Yang, Kejing Ren,Meiling Lu,and Yibei Xiao

Journal: Nucleic Acids Research

PubMed ID: 34428286

Doi: 10.1093/nar/gkab725

Products & Services: Gene Services

Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Authors: Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P Seward, Ricardo Borges, José David Machado

Journal: Cell Rep

PubMed ID: 34433018

Doi: 10.1016/j.celrep.2021.109609

Products & Services: PCR and Cloning

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Authors: Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin

Journal: Blood

PubMed ID: 34359076

Doi: 10.1182/blood.2021012629

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How to Sequence Therapies in Waldenström Macroglobulinemia

Authors: Shayna Sarosiek, Steven P Treon, Jorge J Castillo

Journal: Curr Treat Options Oncol

PubMed ID: 34426943

Doi: 10.1007/s11864-021-00890-9

Products & Services: Protein Reagents and Products

Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates

Authors: Yongzhe Zhang, Fei Liu, Yan Zhao, Fan Yang, Jie Bai, Xitong Jia, Wanlapa Roobsoong, Jetsumon Sattabongkot, Liwang Cui, Yaming Cao, Enjie Luo, Meilian Wang

Journal: Parasit Vectors

PubMed ID: 34399829

Doi: 10.1186/s13071-021-04909-w

Products & Services: Codon Optimization

A novel pine wood nematode effector, BxSCD1, suppresses plant immunity and interacts with an ethylene-forming enzyme in pine

Authors: Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui, Yan Zhang, Xiao-Lei Ding, Jian-Ren Ye

Journal: Mol Plant Pathol

PubMed ID: 34396673

Doi: 10.1111/mpp.13121

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleomodulin Ank13 Exploits the RaDAR Nuclear Import Pathway To Modulate Host Cell Transcription

Authors: Haley E Adcox, Amanda L Hatke, Shelby E Andersen, Sarika Gupta, Nathan B Otto, Mary M Weber, Richard T Marconi, Jason A Carlyon

Journal: MBio

PubMed ID: 34340535

Doi: 10.1128/mBio.01816-21

Products & Services: Codon Optimization

Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Authors: Léa Chuzel, Samantha L Fossa, Madison L Boisvert, Samanta Cajic, René Hennig, Mehul B Ganatra, Udo Reichl, Erdmann Rapp, Christopher H Taron

Journal: Microb Cell Fact

PubMed ID: 34419057

Doi: 10.1186/s12934-021-01652-w

Products & Services: Codon Optimization

Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71)

Authors: Salima Lalani, Malihe Masomian, Chit Laa Poh

Journal: Int J Mol Sci

PubMed ID: 34445463

Doi: 10.3390/ijms22168757

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Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Authors: Kerry L Hilligan, Sivaranjani Namasivayam, Chad S Clancy, Danielle O'Mard, Sandra D Oland, Shelly J Robertson, Paul J Baker, Ehydel Castro, Nicole L Garza, Bernard A P Lafont, Reed Johnson, Franca Ronchese, Katrin D Mayer-Barber, Sonja M Best, Alan Sher

Journal: biorxiv

PubMed ID: 34494021

Doi: 10.1101/2021.08.30.458273

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The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation

Authors: Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek, Natalia O Tjokro, Santiago Partida-Sanchez, Lauren O Bakaletz, Steven D Goodman

Journal: J Clin Invest

PubMed ID: 34396989

Doi: 10.1172/JCI140527

Products & Services: Bacterial Expression

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Authors: Aleksandar Antanasijevic, Leigh M Sewall, Christopher A Cottrell, Diane G Carnathan, Luis E Jimenez, Julia T Ngo, Jennifer B Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D Allen, Jeffrey Copps, Hailee R Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T Berndsen, David Baker, Neil P King, Rogier W Sanders, John P Moore, Shane Crotty, Max Crispin, David C Montefiori, Dennis R Burton, William R Schief, Guido Silvestri, Andrew B Ward

Journal: Nat Commun

PubMed ID: 34376662

Doi: 10.1038/s41467-021-25087-4

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Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast

Authors: Imane M Rezig, Wandiahyel G Yaduma, Gwyn W Gould, Christopher J McInerny

Journal: Cell Cycle

PubMed ID: 34382912

Doi: 10.1080/15384101.2021.1962637

Products & Services: DNA Sequencing

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Authors: Erika Casari, Elisa Gobbini, Marco Gnugnoli, Marco Mangiagalli, Michela Clerici, Maria Pia Longhese

Journal: Nat Commun

PubMed ID: 34362907

Doi: 10.1038/s41467-021-25090-9

Products & Services: Bacterial Expression

Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Authors: Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V Pai, Ramakrishnan Melarkode Subbaraman

Journal: Sci Rep

PubMed ID: 34462514

Doi: 10.1038/s41598-021-96916-1

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Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Authors: Ioannis P Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis, Meletios A Dimopoulos

Journal: BMC Med

PubMed ID: 34420521

Doi: 10.1186/s12916-021-02090-6

Rv0927c Inhibits NF-κB Pathway by Downregulating the Phosphorylation Level of IκBα and Enhances Mycobacterial Survival

Authors: Aihong Xia, Xin Li, Juanjuan Quan, Xiang Chen, Zhengzhong Xu, Xinan Jiao

Journal: Front Immunol

PubMed ID: 34531869

Doi: 10.3389/fimmu.2021.721370

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Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Authors: Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Laia Fontdevila, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin

Journal: Int J Mol Sci

PubMed ID: 34445555

Doi: 10.3390/ijms22168853

Products & Services: Proteins, Expression, Isolation and Analysis

Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer

Authors: Hester A Doyle, Renelle J Gee, Tyler D Masters, Christian R Gee, Carmen J Booth, Elizabeth Peterson-Roth, Raymond A Koski, Stuart C Helfand, Lauren Price, Deborah Bascombe, Dorothy Jackson, Rita Ho, Gerald R Post, Mark J Mamula

Journal: Transl Oncol

PubMed ID: 34419682

Doi: 10.1016/j.tranon.2021.101205

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses

Authors: Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato

Journal: Viruses

PubMed ID: 34578314

Doi: 10.3390/v13091733

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Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Authors: Zhaoyong Zhang, Eric Zeng, Lu Zhang, Weiming Wang, Yingkang Jin, Jiye Sun, Shuxiang Huang, Wenguang Yin, Jun Dai, Zhen Zhuang, Zhao Chen, Jing Sun, Airu Zhu, Fang Li, Weitao Cao, Xiaobo Li, Yongxia Shi, Mian Gan, Shengnan Zhang, Peilan Wei, Jicheng Huang, Nanshan Zhong, Guocai Zhong, Jingxian Zhao, Yanqun Wang, Weihui Shao, Jincun Zhao

Journal: Cell Discov

PubMed ID: 34385423

Doi: 10.1038/s41421-021-00302-0

Products & Services: Mutant Libraries

Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43 in Glioblastoma Stem Cells

Authors: Sara G Pelaz, Claudia Ollauri-Ibáñez, Concepción Lillo, Arantxa Tabernero

Journal: Cancers (Basel)

PubMed ID: 34503072

Doi: 10.3390/cancers13174262

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Genome-Wide Identification and Expression Analysis of MYB Transcription Factor Superfamily in

Authors: Tingting Zhang, Zheng Cui, Yuxin Li, Yuqian Kang, Xiqiang Song, Jian Wang, Yang Zhou

Journal: Front Genet

PubMed ID: 34512725

Doi: 10.3389/fgene.2021.714696

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SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy

Authors: Yajing Zhang, Xiaohong Yu, Qiuping Liu, Haiping Gong, An-An Chen, Hongjun Zheng, Shi Zhong, Yi Li

Journal: Mol Cancer Ther

PubMed ID: 34465596

Doi: 10.1158/1535-7163.MCT-21-0203

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Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity

Authors: Ramona Dolscheid-Pommerich, Eva Bartok, Marcel Renn, Beate M Kümmerer, Bianca Schulte, Ricarda M Schmithausen, Birgit Stoffel-Wagner, Hendrik Streeck, Sandra Saschenbrecker, Katja Steinhagen, Gunther Hartmann

Journal: J Med Virol

PubMed ID: 34415572

Doi: 10.1002/jmv.27287

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Authors: Olusegun O Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A Rouf Banday, Thomas R O'Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson

Journal: Front Immunol

PubMed ID: 34497603

Doi: 10.3389/fimmu.2021.692263

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia

Authors: Wurihan Wurihan, Yi Zou, Alec M Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, Huizhou Fan

Journal: mSystems

PubMed ID: 34342542

Doi: 10.1128/mSystems.00738-21

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Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

Authors: Thomas Güttler, Metin Aksu, Antje Dickmanns, Kim M Stegmann, Kathrin Gregor, Renate Rees, Waltraud Taxer, Oleh Rymarenko, Jürgen Schünemann, Christian Dienemann, Philip Gunkel, Bianka Mussil, Jens Krull, Ulrike Teichmann, Uwe Groß, Volker C Cordes, Matthias Dobbelstein, Dirk Görlich

Journal: EMBO J

PubMed ID: 34302370

Doi: 10.15252/embj.2021107985

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α-Synuclein kinetically regulates the nascent fusion pore dynamics

Authors: Rohith K Nellikka, Bhavya R Bhaskar, Kinjal Sanghrajka, Swapnali S Patil, Debasis Das

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34413185

Doi: 10.1073/pnas.2021742118

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BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments

Authors: Hunter W Kuhn, Amanda G Lasseter, Philip P Adams, Carlos Flores Avile, Brandee L Stone, Darrin R Akins, Travis J Jewett, Mollie W Jewett

Journal: PLoS Pathog

PubMed ID: 34415955

Doi: 10.1371/journal.ppat.1009869

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cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Authors: Takahiro Ishizaki, Masahito Asada, Hassan Hakimi, Nattawat Chaiyawong, Yuto Kegawa, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34390881

Doi: 10.1016/j.parint.2021.102435

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Genome-wide Analysis of Basic Helix-Loop-Helix Family Genes and Expression Analysis in Response to Drought and Salt Stresses in Sieb et Zucc

Authors: Longjie Ni, Zhiquan Wang, Zekai Fu, Dina Liu, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Int J Mol Sci

PubMed ID: 34445454

Doi: 10.3390/ijms22168748

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Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

Authors: V Dumrongprechachan, R B Salisbury, G Soto, M Kumar, M L MacDonald, Y Kozorovitskiy

Journal: Nat Commun

PubMed ID: 34381044

Doi: 10.1038/s41467-021-25144-y

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Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Authors: Qingzhuoma Yang, Shengtao Guo, Qi Lu, Yong Tao, Decong Zheng, Qinmao Zhou, Jun Liu

Journal: Biosci Rep

PubMed ID: 34338280

Doi: 10.1042/BSR20211135

Products & Services: Proteins, Expression, Isolation and Analysis

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha El Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Journal: EBioMedicine

PubMed ID: 34388518

Doi: 10.1016/j.ebiom.2021.103521

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Genome-wide characterization and expression profiling of the Phospholipase C (PLC) gene family in three orchids of economic importance

Authors: Madhvi Kanchan, Thakku R Ramkumar, Jaspreet K Sembi

Journal: J Genet Eng Biotechnol

PubMed ID: 34420115

Doi: 10.1186/s43141-021-00217-z

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The nucleotide addition cycle of the SARS-CoV-2 polymerase

Authors: Subhas Chandra Bera, Mona Seifert, Robert N Kirchdoerfer, Pauline van Nies, Yibulayin Wubulikasimu, Salina Quack, Flávia S Papini, Jamie J Arnold, Bruno Canard, Craig E Cameron, Martin Depken, David Dulin

Journal: Cell Rep

PubMed ID: 34433083

Doi: 10.1016/j.celrep.2021.109650

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Spore-Trained Dendritic Cells Enhance the Generation of Memory T Cells via ICAM1

Authors: Jian Lin, Lulu Huang, Yuchen Li, Penghao Zhang, Qinghua Yu, Qian Yang

Journal: Cells

PubMed ID: 34571913

Doi: 10.3390/cells10092267

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Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery

Authors: Chengqian Feng, Jingrong Shi, Qinghong Fan, Yaping Wang, Huang Huang, Fengjuan Chen, Guofang Tang, Youxia Li, Pingchao Li, Jiaojiao Li, Jianping Cui, Liliangzi Guo, Sisi Chen, Mengling Jiang, Liqiang Feng, Ling Chen, Chunliang Lei, Changwen Ke, Xilong Deng, Fengyu Hu, Xiaoping Tang, Feng Li

Journal: Nat Commun

PubMed ID: 34404803

Doi: 10.1038/s41467-021-25312-0

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A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses

Authors: Cansu Cimen Bozkus, Ana Belen Blazquez, Tomohiro Enokida, Nina Bhardwaj

Journal: STAR Protoc

PubMed ID: 34458873

Doi: 10.1016/j.xpro.2021.100758

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N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Authors: Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick C J Dobson

Journal: J Biol Chem

PubMed ID: 34437902

Doi: 10.1016/j.jbc.2021.101113

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PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

Authors: Hui Li, Defang Meng, Jieting Jia, Hua Wei

Journal: Lipids Health Dis

PubMed ID: 34461924

Doi: 10.1186/s12944-021-01515-8

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Vestibular and Auditory Hair Cell Regeneration Following Targeted Ablation of Hair Cells With Diphtheria Toxin in Zebrafish

Authors: Erin Jimenez, Claire C Slevin, Luis Colón-Cruz, Shawn M Burgess

Journal: Front Cell Neurosci

PubMed ID: 34489643

Doi: 10.3389/fncel.2021.721950

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Genome-Wide Identification, Expression and Functional Analysis Reveal the Involvement of FCS-Like Zinc Finger Gene Family in Submergence Response in Rice

Authors: Yamei Ma, Junliang Zhao, Hua Fu, Tifeng Yang, Jingfang Dong, Wu Yang, Luo Chen, Lian Zhou, Jian Wang, Bin Liu, Shaohong Zhang, David Edwards

Journal: Rice (N Y)

PubMed ID: 34417910

Doi: 10.1186/s12284-021-00519-3

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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4 T-cells

Authors: Vijaya L Simhadri, Louis Hopkins, Joseph R McGill, Brian R Duke, Swati Mukherjee, Kate Zhang, Zuben E Sauna

Journal: Nat Commun

PubMed ID: 34429421

Doi: 10.1038/s41467-021-25414-9

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Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish

Authors: Caitlin Hyland, Michael Mfarej, Giorgos Hiotis, Sabrina Lancaster, Noelle Novak, M Kathryn Iovine, Matthias M Falk

Journal: Mol Biol Cell

PubMed ID: 34379446

Doi: 10.1091/mbc.E20-12-0797

Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM

Authors: Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong Cheung, Jason S Lewis

Journal: J Nucl Med

PubMed ID: 34353869

Doi: 10.2967/jnumed.121.262383

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The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol

Authors: Haruka Sudo, Akira Kubo

Journal: Int J Mol Sci

PubMed ID: 34502304

Doi: 10.3390/ijms22179397

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Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy

Authors: Xiaobei Cheng, Pei Yu, Xiang Zhou, Jiale Zhu, Yubao Han, Chao Zhang, Lingyi Kong

Journal: Acta Pharm Sin B

PubMed ID: 35256955

Doi: 10.1016/j.apsb.2021.08.018

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Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow's Milk Allergy

Authors: Yaqiong Cui, Yang Yu, Shuxiang Lin, Li Xu, Liuxu Li, Chunquan Cai, Huiqiang Li

Journal: Int Arch Allergy Immunol

PubMed ID: 34515139

Doi: 10.1159/000517998

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Molecular Cloning and Expression Profile of Class Genes Related to Sepal Development in

Authors: Zhuoxing Liu, Dasheng Zhang, Weiwei Zhang, Lei Xiong, Qingqing Liu, Fengluan Liu, Hanchun Li, Xiangjie An, Lijie Cui, Daike Tian

Journal: Plants (Basel)

PubMed ID: 34451674

Doi: 10.3390/plants10081629

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Evidence that class I glutamine amidotransferase, GAT1_21, acts as a glutaminase in roots of Arabidopsis thaliana

Authors: Shrikaar Kambhampati, Aga Pajak, Frédéric Marsolais

Journal: Plant Sci

PubMed ID: 34620437

Doi: 10.1016/j.plantsci.2021.111033

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Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins

Authors: Jongjin Park, Jiyoung Yoon, Daekee Kwon, Mi-Jung Han, Sunmee Choi, Slki Park, Junghyuk Lee, Kiwook Lee, Jaehwan Lee, Seunghee Lee, Kyung-Sun Kang, Sunghwa Choe

Journal: Sci Rep

PubMed ID: 34376729

Doi: 10.1038/s41598-021-95406-8

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Der p 38 Is a Bidirectional Regulator of Eosinophils and Neutrophils in Allergy

Authors: Min Hwa Hong, Ayesha Kashif, Geunyeong Kim, Beom Seok Park, Na Rae Lee, Eun Ju Yang, Ji Young Mun, Hyosun Choi, Sang-Hoon Kim, Hyun Jik Kim, Soo Jin Lee, Ji-Sook Lee, Yujin Hong, In Sik Kim

Journal: J Immunol

PubMed ID: 34462314

Doi: 10.4049/jimmunol.2001144

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Quantitative SARS-CoV-2 Spike Antibody Response in COVID-19 Patients Using Three Fully Automated Immunoassays and a Surrogate Virus Neutralization Test

Authors: Yoonjoo Kim, Ji Hyun Lee, Geon Young Ko, Ji Hyeong Ryu, Joo Hee Jang, Hyunjoo Bae, Seung-Hyo Yoo, Ae-Ran Choi, Jin Jung, Jongmin Lee, Eun-Jee Oh

Journal: Diagnostics (Basel)

PubMed ID: 34441430

Doi: 10.3390/diagnostics11081496

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Novel Host Recognition Mechanism of the K1 Capsule-Specific Phage of : Capsular Polysaccharide as the First Receptor and Lipopolysaccharide as the Secondary Receptor

Authors: Qianwen Gong, Xuhang Wang, Haosheng Huang, Yu Sun, Xinjie Qian, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang

Journal: J Virol

PubMed ID: 34191582

Doi: 10.1128/JVI.00920-21

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Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways

Authors: Lihe Sun, Juan Ouyang, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng, Shuizhu Wu

Journal: Bioact Mater

PubMed ID: 34901531

Doi: 10.1016/j.bioactmat.2021.08.010

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TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways

Authors: Alex Jose Pulikkottil, Shiva Bamezai, Tobias Ammer, Fabian Mohr, Kristin Feder, Naidu M Vegi, Tamoghna Mandal, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Amit Sinha, Christian Buske, Vijay P S Rawat

Journal: Leukemia

PubMed ID: 34462525

Doi: 10.1038/s41375-021-01390-3

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Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients

Authors: Victoria G Hall, Victor H Ferreira, Terrance Ku, Matthew Ierullo, Beata Majchrzak-Kita, Cecilia Chaparro, Nazia Selzner, Jeffrey Schiff, Michael McDonald, George Tomlinson, Vathany Kulasingam, Deepali Kumar, Atul Humar

Journal: N Engl J Med

PubMed ID: 34379917

Doi: 10.1056/NEJMc2111462

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Context-Specific Function of the Engineered Peptide Domain of PHPB

Authors: R Alexander Martino, Edwin C Fluck, Jacqueline Murphy, Qiang Wang, Henry Hoff, Ruth A Pumroy, Claudia Y Lee, Joshua J Sims, Soumitra Roy, Vera Y Moiseenkova-Bell, James M Wilson

Journal: J Virol

PubMed ID: 34346767

Doi: 10.1128/JVI.01164-21

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Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src

Authors: Xiao-Li Jiang, Bo Deng, Sui-Hui Deng, Min Cai, Wen-Jun Ding, Zhang-Bin Tan, Rui-Xue Chen, You-Cai Xu, Hong-Lin Xu, Shuang-Wei Zhang, Shi-Qing Zhang, Bin Liu, Jing-Zhi Zhang

Journal: Phytomedicine

PubMed ID: 34538671

Doi: 10.1016/j.phymed.2021.153705

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Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2

Authors: Yuqiang Zhang, Yan Xu, Yunpeng Dai, Zhe Li, Jiaxing Wang, Zhi Ye, Yanxin Ren, Hua Wang, Wan-Xiang Li, Jinfeng Lu, Shou-Wei Ding, Yang Li

Journal: PLoS Pathog

PubMed ID: 34343211

Doi: 10.1371/journal.ppat.1009790

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Multigenerational selection towards longevity changes the protective role of vitamin C against graphene oxide-induced oxidative stress in house crickets

Authors: Barbara Flasz, Marta Dziewięcka, Andrzej Kędziorski, Monika Tarnawska, Jan Augustyniak, Maria Augustyniak