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Metabolic engineering of Bacillus subtilis with an endopolygalacturonase gene isolated from Pectobacterium carotovorum; a plant pathogenic bacterial strain

Authors: Nagina Rafique, Saiqa Bashir, Muhammad Zubair Khan, Imran Hayat, Willium Orts, Dominic W S Wong

Journal: PLoS ONE

PubMed ID: 34936645

Doi: 10.1371/journal.pone.0256562

Products & Services: Gene Synthesis

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: medrxiv

PubMed ID: 34909788

Doi: 10.1101/2021.12.08.21267417

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Local Charge Distributions, Electric Dipole Moments, and Local Electric Fields Influence Reactivity Patterns and Guide Regioselectivities in α-Ketoglutarate-Dependent Non-heme Iron Dioxygenases

Authors: Sam P de Visser, Gourab Mukherjee, Hafiz Saqib Ali, Chivukula V Sastri

Journal: Acc Chem Res

PubMed ID: 34915695

Doi: 10.1021/acs.accounts.1c00538

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Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

Authors: Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34975748

Doi: 10.3389/fendo.2021.762691

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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Authors: Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, Daniel Herp, Policarpo A Sales-Junior, Eloise P Guerra-Slompo, Kristin Hausmann, Alokta Chakrabarti, Tajith B Shaik, Annika Merz, Edouard Troesch, Karin Schmidtkunz, Samuel Goldenberg, Raymond J Pierce, Marina M Mourão, Manfred Jung, Johan Schultz, Wolfgang Sippl, Nilson I T Zanchin, Christophe Romier

Journal: Cell Rep

PubMed ID: 34936867

Doi: 10.1016/j.celrep.2021.110129

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Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle

Authors: Li Zhu, Xinyu Li, Henan Xu, Lifeng Fu, George Fu Gao, Wenjun Liu, Linqing Zhao, Xiaojun Wang, Wei Jiang, Min Fang

Journal: J Gen Virol

PubMed ID: 34882534

Doi: 10.1099/jgv.0.001697

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In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei

Authors: Abhishek Dey, Anais Monroy-Eklund, Kaitlin Klotz, Arpita Saha, Justin Davis, Bibo Li, Alain Laederach, Kausik Chakrabarti

Journal: Nucleic Acids Res

PubMed ID: 34850114

Doi: 10.1093/nar/gkab1042

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β-galactosidase GALA from with high transgalactosylation activity

Authors: Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang, Yuhong Zhang

Journal: Bioengineered

PubMed ID: 34606421

Doi: 10.1080/21655979.2021.1988370

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A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

Authors: Xiangchuan He, Longfei Ding, Kangli Cao, Haoran Peng, Chenjian Gu, Yutang Li, Duoduo Li, Lanlan Dong, Xiujing Hong, Xiangwei Wang, Meilan Fu, Chenli Qiu, Cuisong Zhu, Ziling Zhang, Shu Song, Chenguang Wang, Zhengfan Jiang, Youhua Xie, Zhongtian Qi, Chen Zhao, Ping Zhao, Xiaoyan Zhang, Jianqing Xu

Journal: Emerg Microbes Infect

PubMed ID: 34304724

Doi: 10.1080/22221751.2021.1957400

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Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

Authors: Jiaojiao Liu, Kun Xu, Man Xing, Yue Zhuo, Jingao Guo, Meng Du, Qi Wang, Yaling An, Jinhe Li, Ping Gao, Yihan Wang, Furong He, Yingying Guo, Mingxi Li, Yuchao Zhang, Linqi Zhang, George F Gao, Lianpan Dai, Dongming Zhou

Journal: Cell Discov

PubMed ID: 34923570

Doi: 10.1038/s41421-021-00360-4

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Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells

Authors: Basma Tarek, Julia Bruggisser, Filippo Cattalani, Horst Posthaus

Journal: Toxins (Basel)

PubMed ID: 34941730

Doi: 10.3390/toxins13120893

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Small molecule splicing modifiers with systemic HTT-lowering activity

Authors: Anuradha Bhattacharyya, Christopher R Trotta, Jana Narasimhan, Kari J Wiedinger, Wencheng Li, Kerstin A Effenberger, Matthew G Woll, Minakshi B Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A Naryshkin, Jason D Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M Colacino, Stuart W Peltz

Journal: Nat Commun

PubMed ID: 34911927

Doi: 10.1038/s41467-021-27157-z

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Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2

Authors: Kristen A Rodrigues, Sergio A Rodriguez-Aponte, Neil C Dalvie, Jeong Hyun Lee, Wuhbet Abraham, Diane G Carnathan, Luis E Jimenez, Julia T Ngo, Jason Y H Chang, Zeli Zhang, Jingyou Yu, Aiquan Chang, Catherine Nakao, Benjamin Goodwin, Christopher A Naranjo, Libin Zhang, Murillo Silva, Dan H Barouch, Guido Silvestri, Shane Crotty, J Christopher Love, Darrell J Irvine

Journal: Sci Adv

PubMed ID: 34878851

Doi: 10.1126/sciadv.abj6538

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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

Authors: Yalan Deng, Xianghou Xia, Yang Zhao, Zilong Zhao, Consuelo Martinez, Wenjuan Yin, Jun Yao, Qinglei Hang, Weiche Wu, Jie Zhang, Yang Yu, Weiya Xia, Fan Yao, Di Zhao, Yutong Sun, Haoqiang Ying, Mien-Chie Hung, Li Ma

Journal: Nat Commun

PubMed ID: 34873175

Doi: 10.1038/s41467-021-27349-7

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Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)

Authors: Prakash G Kshirsagar, Mansi Gulati, Wade M Junker, Abhijit Aithal, Gaelle Spagnol, Srustidhar Das, Kavita Mallya, Shailendra K Gautam, Sushil Kumar, Paul Sorgen, Krishan K Pandey, Surinder K Batra, Maneesh Jain

Journal: Sci Rep

PubMed ID: 34887447

Doi: 10.1038/s41598-021-02860-5

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Biosynthesis of the redox cofactor mycofactocin is controlled by the transcriptional regulator MftR and induced by long chain acyl-CoA species

Authors: Aigera Mendauletova, John A Latham

Journal: J Biol Chem

PubMed ID: 34896395

Doi: 10.1016/j.jbc.2021.101474

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Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes

Authors: Yitong Guo, Zhuo Wan, Ping Zhao, Mengying Wei, Yunnan Liu, Te Bu, Wenqi Sun, Zhelong Li, Lijun Yuan

Journal: J Nanobiotechnology

PubMed ID: 34863187

Doi: 10.1186/s12951-021-01145-3

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Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1

Authors: Junmo Hwang, Kunwoong Park, Ga-Young Lee, Bo Young Yoon, Hyunmin Kim, Sung Hoon Roh, Byoung-Cheol Lee, Kipom Kim, Hyun-Ho Lim

Journal: Open Biol

PubMed ID: 34847774

Doi: 10.1098/rsob.210103

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PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc

Authors: Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini

Journal: Int J Mol Sci

PubMed ID: 34884931

Doi: 10.3390/ijms222313122

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Antiviral RNA interference in disease vector (Asian longhorned) ticks

Authors: Yan Xu, Zhengwei Zhong, Yanxin Ren, Liting Ma, Zhi Ye, Chuang Gao, Jingwen Wang, Yang Li

Journal: PLoS Pathog

PubMed ID: 34860862

Doi: 10.1371/journal.ppat.1010119

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Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures

Authors: Denise Liano, Souroprobho Chowdhury, Marco Di Antonio

Journal: J Am Chem Soc

PubMed ID: 34855372

Doi: 10.1021/jacs.1c10745

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SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin

Authors: Heather J Kolpa, Kevin M Creamer, Lisa L Hall, Jeanne B Lawrence

Journal: Mamm Genome

PubMed ID: 34859278

Doi: 10.1007/s00335-021-09935-8

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Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Authors: Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C Faustino, Kookjoo Kim, Oliver B Clarke, Hanxi Hou, Yaron Tomer

Journal: Front Immunol

PubMed ID: 34987519

Doi: 10.3389/fimmu.2021.796552

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Characterization and expression analysis of the SPL gene family during floral development and abiotic stress in pecan ()

Authors: Min Wang, Zhenghai Mo, Ruozhu Lin, Cancan Zhu

Journal: PeerJ

PubMed ID: 34966577

Doi: 10.7717/peerj.12490

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Constructing DNA logic circuits based on the toehold preemption mechanism

Authors: Cuicui Xing, Xuedong Zheng, Qiang Zhang

Journal: RSC Adv

PubMed ID: 35424506

Doi: 10.1039/d1ra08687a

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Novel Tyrosine Kinase-Mediated Phosphorylation With Dual Specificity Plays a Key Role in the Modulation of Physiology and Virulence

Authors: Sashi Kant, Vijay Pancholi

Journal: Front Microbiol

PubMed ID: 34950110

Doi: 10.3389/fmicb.2021.689246

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Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Authors: Özlem Şen, Attilio Marino, Carlotta Pucci, Gianni Ciofani

Journal: Mater Today Bio

PubMed ID: 35005600

Doi: 10.1016/j.mtbio.2021.100196

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High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster

Authors: Julia R Port, Danielle R Adney, Benjamin Schwarz, Jonathan E Schulz, Daniel E Sturdevant, Brian J Smith, Victoria A Avanzato, Myndi G Holbrook, Jyothi N Purushotham, Kaitlin A Stromberg, Ian Leighton, Catharine M Bosio, Carl Shaia, Vincent J Munster

Journal: Viruses

PubMed ID: 34960775

Doi: 10.3390/v13122506

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Djulis Hull Improves Insulin Resistance and Modulates the Gut Microbiota in High-Fat Diet (HFD)-Induced Hyperglycaemia

Authors: Yu-Tang Tung, Jun-Lan Zeng, Shang-Tse Ho, Jin-Wei Xu, I-Hsuan Lin, Jyh-Horng Wu

Journal: Antioxidants (Basel)

PubMed ID: 35052549

Doi: 10.3390/antiox11010045

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Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

Authors: Lu Xu, Bo Chen, Hannes Schihada, Shane C Wright, Ainoleena Turku, Yiran Wu, Gye-Won Han, Maria Kowalski-Jahn, Pawel Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, Michel Bouvier, Gunnar Schulte, Fei Xu

Journal: Cell Research

PubMed ID: 34239071

Doi: 10.1038/s41422-021-00525-6

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Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity

Authors: Ha N Duong, Sung-Hwan Cho, Limin Wang, An Q Pham, Julia M Davies, Gary Stacey

Journal: Plant J

PubMed ID: 34919778

Doi: 10.1111/tpj.15636

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Variation in Severe Acute Respiratory Syndrome Coronavirus 2 Bioaerosol Production in Exhaled Breath

Authors: Renu Verma, Eugene Kim, Nicholas Degner, Katharine S Walter, Upinder Singh, Jason R Andrews

Journal: Open Forum Infect Dis

PubMed ID: 35028332

Doi: 10.1093/ofid/ofab600

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MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2

Authors: Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu

Journal: Bioengineered

PubMed ID: 34699325

Doi: 10.1080/21655979.2021.1996505

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Creation of a recombinant Komagataella phaffii strain, a producer of proteinase K from Tritirachium album

Authors: A B Beklemishev, M B Pykhtina, Ya M Kulikov, T N Goryachkovskaya, D V Bochkov, S V Sergeeva, A R Vasileva, V P Romanov, D S Novikova, S E Peltek

Journal: Vavilovskii Zhurnal Genet Selektsii

PubMed ID: 35083407

Doi: 10.18699/VJ21.102

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Curcumin modulates airway remodelling-contributing genes-the significance of transcription factors

Authors: Joanna Wieczfinska, Przemysław Sitarek, Tomasz Kowalczyk, Piotr Rieske, Rafal Pawliczak

Journal: J Cell Mol Med

PubMed ID: 34939316

Doi: 10.1111/jcmm.17102

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ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models

Authors: Linxi Zhu, Qingxin Mu, Jesse Yu, James I Griffin, Xiaolin Xu, Rodney J Y Ho

Journal: Pharmaceutics

PubMed ID: 35056985

Doi: 10.3390/pharmaceutics14010089

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MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells

Authors: Siyuan Gao, Jing Zhao, Qinglei Xu, Yanli Guo, Mingzheng Liu, Chunlei Zhang, Allan P Schinckel, Bo Zhou

Journal: Theriogenology

PubMed ID: 34959084

Doi: 10.1016/j.theriogenology.2021.12.014

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Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs

Authors: Giovanni Romito, Elena Venturelli, Vanna Tintorri, Mario Cipone

Journal: J Vet Med Sci

PubMed ID: 34955461

Doi: 10.1292/jvms.21-0571

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A metabolic labeling protocol to enrich myristoylated proteins from

Authors: Xin Gong, Yanwen Feng, Hongyun Tang

Journal: STAR Protoc

PubMed ID: 34917984

Doi: 10.1016/j.xpro.2021.101013

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Key factors determining competitions between double-stranded RNAs in Tribolium castaneum

Authors: Xu Shen, Yingchuan Peng, Huifang Song, Jinda Wang, Jun Zhao, Peian Tang, Zhaojun Han, Kangxu Wang

Journal: Pestic Biochem Physiol

PubMed ID: 35082032

Doi: 10.1016/j.pestbp.2021.105009

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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver

Authors: Leire Goicoechea, Fabian Arenas, Fernanda Castro, Susana Nuñez, Sandra Torres, Carmen Garcia-Ruiz, José C Fernandez-Checa

Journal: STAR Protoc

PubMed ID: 35024626

Doi: 10.1016/j.xpro.2021.101068

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Protein S-Nitrosylation Regulates Postmortem Beef Apoptosis through the Intrinsic Mitochondrial Pathway

Authors: Qin Hou, Qiongniu Zhu, Wenwei Lu, Wangang Zhang

Journal: J Agric Food Chem

PubMed ID: 34968404

Doi: 10.1021/acs.jafc.1c06516

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Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

Authors: Jingru Guo, Yujing Bai, Yunxie Wei, Yabin Dong, Hongqiu Zeng, Russel J Reiter, Haitao Shi

Journal: J Pineal Res

PubMed ID: 34936113

Doi: 10.1111/jpi.12784

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An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

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Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

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Comparative analysis of mussel foot protein 3B co-expressed with tyrosinases provides a potential adhesive biomaterial

Authors: Lin Yao, Xinyi Wang, Rui Xue, Hong Xu, Rui Wang, Lujia Zhang, Sha Li

Journal: Int J Biol Macromol

PubMed ID: 34896153

Doi: 10.1016/j.ijbiomac.2021.11.208

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Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

Authors: Yi-Ping Liu, Zhong-Zhi Qiu, Xu-Hui Li, En-You Li

Journal: World J Gastrointest Oncol

PubMed ID: 35070046

Doi: 10.4251/wjgo.v13.i12.2114

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CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients

Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Samuele Tardito

Journal: Arthritis Res Ther

PubMed ID: 34952630

Doi: 10.1186/s13075-021-02691-9

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The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism

Authors: Jennifer A Buffa, Kymberleigh A Romano, Matthew F Copeland, David B Cody, Weifei Zhu, Rachel Galvez, Xiaoming Fu, Kathryn Ward, Marc Ferrell, Hong J Dai, Sarah Skye, Ping Hu, Lin Li, Mirjana Parlov, Amy McMillan, Xingtao Wei, Ina Nemet, Robert A Koeth, Xinmin S Li, Zeneng Wang, Naseer Sangwan, Adeline M Hajjar, Mohammed Dwidar, Taylor L Weeks, Nathalie Bergeron, Ronald M Krauss, W H Wilson Tang, Federico E Rey, Joseph A DiDonato, Valentin Gogonea, G Frank Gerberick, Jose Carlos Garcia-Garcia, Stanley L Hazen

Journal: Nat Microbiol

PubMed ID: 34949826

Doi: 10.1038/s41564-021-01010-x

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Genome-Wide Identification, Primary Functional Characterization of the Gene Family in and Their Possible Roles for Adaptation to Tropical Coral Reefs

Authors: Lin Pu, Ruoyi Lin, Tao Zou, Zhengfeng Wang, Mei Zhang, Shuguang Jian

Journal: Genes (Basel)

PubMed ID: 35052375

Doi: 10.3390/genes13010033

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Genome-Wide Identification, Primary Functional Characterization of the Gene Family in and Their Possible Roles for Adaptation to Tropical Coral Reefs

Authors: Lin Pu, Ruoyi Lin, Tao Zou, Zhengfeng Wang, Mei Zhang, Shuguang Jian

Journal: Genes (Basel)

PubMed ID: 35052375

Doi: 10.3390/genes13010033

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Repertoire-scale antibody structural prediction informs therapeutic design

Authors: Zhe Sang; Yufei Xiang; Wei Huang; Paul R. Sargunas; Yong Joon (Jeffery) Kim; Zirui Feng; Derek J. Taylor; Yi Shi

Journal: SCIENCE ADVANCES

PubMed ID: 42030385

Doi: 10.1126/sciadv.aef7163

Repertoire-scale antibody structural prediction informs therapeutic design

Authors: Zhe Sang; Yufei Xiang; Wei Huang; Paul R. Sargunas; Yong Joon (Jeffery) Kim; Zirui Feng; Derek J. Taylor; Yi Shi

Journal: SCIENCE ADVANCES

PubMed ID: 42030385

Doi: 10.1126/sciadv.aef7163

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

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Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

Authors: Nessma A El-Zawawy, Mahy M Mona

Journal: Sci Rep

PubMed ID: 34934098

Doi: 10.1038/s41598-021-03664-3

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The key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus

Authors: Dan Wang, Zhanmin Sun, Xinxu Hu, Junbo Xiong, Lizhen Hu, Yuandong Xu, Yixiong Tang, Yanmin Wu

Journal: BMC Plant Biol

PubMed ID: 34965872

Doi: 10.1186/s12870-021-03336-4

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KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3

Authors: Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun

Journal: Int J Mol Sci

PubMed ID: 35008530

Doi: 10.3390/ijms23010104

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Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T‑Cell Epitopes for Cancer Immunotherapy

Authors: Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, and Yumiao Zhang

Journal: Chem. Mater.

Doi: 10.1021/acs.chemmater.1c03681

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Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients

Authors: Qihong Yan, Ping He, Xiaohan Huang, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu, Xuefeng Niu, Ling Chen

Journal: Emerg Microbes Infect

PubMed ID: 33944697

Doi: 10.1080/22221751.2021.1925594

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Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease

Authors: Jeong Seok Yu, Gi Soo Youn, Jieun Choi, Chang-Ho Kim, Byung Yong Kim, Seung-Jo Yang, Je Hee Lee, Tae-Sik Park, Byoung Kook Kim, Yeon Bee Kim, Seong Woon Roh, Byeong Hyun Min, Hee Jin Park, Sang Jun Yoon, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Hotaik Sung, Sang Hak Han, Ki Tae Suk, Do Yup Lee

Journal: Clin Transl Med

PubMed ID: 34965016

Doi: 10.1002/ctm2.634

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P2X7 receptor: the regulator of glioma tumor development and survival

Authors: Damian Matyśniak, Vira Chumak, Natalia Nowak, Artur Kukla, Lilya Lehka, Magdalena Oslislok, Paweł Pomorski

Journal: Purinergic Signal

PubMed ID: 34964926

Doi: 10.1007/s11302-021-09834-2

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EZH2 targeting to improve the sensitivity of acquired radio-resistance bladder cancer cells

Authors: Xiangyan Zhang, Xiangli Ma, Quanxin Wang, Zhaolu Kong

Journal: Transl Oncol

PubMed ID: 34952334

Doi: 10.1016/j.tranon.2021.101316

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T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways

Authors: Haixia Liu, Mei Song, Xiaoyan Sun, Xin Zhang, Huayan Miao, Yankui Wang

Journal: Bioengineered

PubMed ID: 33557670

Doi: 10.1080/21655979.2021.1880732

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Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway

Authors: Man Luo, Wei Sun, Xiangqing Kong

Journal: Ann Anat

PubMed ID: 34958913

Doi: 10.1016/j.aanat.2021.151885

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Development and validation of novel kit for quantification of SARS-CoV-2 antibodies on clinical samples

Authors: Sneha Kumari, Anoushka Raina, Dinesh Chandra, Nikita Gupta, Nikki Dey, Amit Kumar Bhardwaj, Archana Anthwal, Vikash C Mishra, Vimarsh Raina, Aseem K Tiwari, Rasika Setia, A S Bhatia

Journal: J Virol Methods

PubMed ID: 34919976

Doi: 10.1016/j.jviromet.2021.114423

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Preclinical Immune Response and Safety Evaluation of the Protein Subunit Vaccine Nanocovax for COVID-19

Authors: Thi Nhu Mai Tran, Bruce Pearson May, Trong Thuan Ung, Mai Khoi Nguyen, Thi Thuy Trang Nguyen, Van Long Dinh, Chinh Chung Doan, The Vinh Tran, Hiep Khong, Thi Thanh Truc Nguyen, Hoang Quoc Huy Hua, Viet Anh Nguyen, Tan Phat Ha, Dang Luu Phan, Truong An Nguyen, Thi Ngoc Bui, Tieu My Tu, Thi Theo Nguyen, Thi Thuy Hang Le, Thi Lan Dong, Trong Hieu Huynh, Phien Huong Ho, Nguyen Thanh Thao Le, Cong Thao Truong, Hoang Phi Pham, Cong Y Luong, Nie Lim Y, Minh Ngoc Cao, Duy Khanh Nguyen, Thi Thanh Le, Duc Cuong Vuong, Le Khanh Hang Nguyen, Minh Si Do

Journal: Front Immunol

PubMed ID: 34938290

Doi: 10.3389/fimmu.2021.766112

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A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

Authors: Kangli Cao, Xiang Wang, Haoran Peng, Longfei Ding, Xiangwei Wang, Yangyang Hu, Lanlan Dong, Tianhan Yang, Xiujing Hong, Man Xing, Duoduo Li, Cuisong Zhu, Xiangchuan He, Chen Zhao, Ping Zhao, Dongming Zhou, Xiaoyan Zhang, Jianqing Xu

Journal: J Virol

PubMed ID: 34908443

Doi: 10.1128/JVI.01578-21

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MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)

Authors: Huang Jinghua, Zhou Qinghua, Chen Chenchen, Chen Lili, Xu Xiao, Wang Yunfei, An Zhengzhe, Lin Changxiu, Han Hui

Journal: Bioengineered

PubMed ID: 34082648

Doi: 10.1080/21655979.2021.1924543

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Staphylococcus aureus N-terminus formylated δ-toxin tends to form amyloid fibrils, while the deformylated δ-toxin tends to form functional oligomer complexes

Authors: Xinyu Zhou, Yuling Zheng, Qingyu Lv, Decong Kong, Bin Ji, Xuelian Han, Dongsheng Zhou, Zeyu Sun, Li Zhu, Peng Liu, Hua Jiang, Yongqiang Jiang

Journal: Virulence

PubMed ID: 34028320

Doi: 10.1080/21505594.2021.1928395

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Advances in Approaches to Study Chromatin-Mediated Epigenetic Memory

Authors: Yuan Yao, Qing Wen, Tianjun Zhang, Chuanhe Yu, Kui Ming Chan, Haiyun Gan

Journal: ACS Synth Biol

PubMed ID: 34965084

Doi: 10.1021/acssynbio.1c00394

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Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Authors: Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K W To, Kwok-Yung Yuen, Kin-Hang Kok

Journal: Emerg Microbes Infect

PubMed ID: 34003073

Doi: 10.1080/22221751.2021.1931465

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Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway

Authors: Kelan Yuan, Jiao Zheng, Xiao Shen, Yaying Wu, Yu Han, Xiuming Jin, Xiaodan Huang

Journal: Int Immunopharmacol

PubMed ID: 34906854

Doi: 10.1016/j.intimp.2021.108426

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Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

Authors: Kimberly Nellenbach, Alexander Kyu, Nina Guzzetta, Ashley C Brown

Journal: Blood Adv

PubMed ID: 34555851

Doi: 10.1182/bloodadvances.2021004417

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Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression

Authors: Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng, Heng Song, Xiang Zhou

Journal: Nucleic Acids Res

PubMed ID: 34850126

Doi: 10.1093/nar/gkab1124

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Engineering Ligand and Receptor Pairs with LIPSTIC to Track Cell-Cell Interactions

Authors: Dafne Alberti, Michelle Guarniero, Agnieszka K Maciola, Enrico Dotta, Giulia Pasqual

Journal: Curr Protoc

PubMed ID: 34870906

Doi: 10.1002/cpz1.311

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SARS-CoV-2 vaccine in patients with systemic sclerosis: Impact of disease subtype and therapy

Authors: Percival Degrava Sampaio-Barros, Ana Cristina Medeiros-Ribeiro, Ana Paula Luppino-Assad, Renata Miossi, Henrique Carriço da Silva, Emily F V N Yuki, Sandra G Pasoto, Carla G S Saad, Clóvis A Silva, Léonard V K Kupa, Giordano B H Deveza, Tatiana N Pedrosa, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34894235

Doi: 10.1093/rheumatology/keab886

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Authors:

Journal: Lancet Infect Dis

PubMed ID: 34953520

Doi: 10.1016/S1473-3099(21)00751-9

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Cryptic splicing events result in unexpected protein products from calpain-10 (CAPN10) cDNA

Authors: Yasuko Ono, Naoko Doi, Mayumi Shindo, Pablo Pánico, Ana María Salazar

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 34906616

Doi: 10.1016/j.bbamcr.2021.119188

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Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

Authors: Jennifer West, Sandeep Satapathy, Daniel R Whiten, Megan Kelly, Nicholas J Geraghty, Emma-Jayne Proctor, Pietro Sormanni, Michele Vendruscolo, Joel N Buxbaum, Marie Ranson, Mark R Wilson

Journal: Sci Adv

PubMed ID: 34890220

Doi: 10.1126/sciadv.abf7606

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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Authors: Emma L Lewis, Rong Xu, Jean-Christophe Beltra, Shin Foong Ngiow, Jordana Cohen, Rahul Telange, Alexander Crane, Deirdre Sawinski, E John Wherry, Paige M Porrett

Journal: J Exp Med

PubMed ID: 34882194

Doi: 10.1084/jem.20201599

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The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction

Authors: Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang, Jianghua Zhong

Journal: Bioengineered

PubMed ID: 34506248

Doi: 10.1080/21655979.2021.1964894

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Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

Authors: Luke F Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S Jardetzky

Journal: Nat Commun

PubMed ID: 34862384

Doi: 10.1038/s41467-021-27397-z

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MON-2, a Golgi protein, mediates autophagy-dependent longevity in

Authors: Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom, Ara B Hwang, Dae-Eun Jeong, Özlem Altintas, Keunhee Seo, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Yujin Lee, Jooyeon Sohn, Eun Ji E Kim, Sungeun Ju, Seong Kyu Han, Hyun-Jun Nam, Linnea Adams, Youngjae Ryu, Dong Jin Moon, Chanhee Kang, Joo-Yeon Yoo, Sang Ki Park, Chang Man Ha, Malene Hansen, Sanguk Kim, Cheolju Lee, Seung-Yeol Park, Seung-Jae V Lee

Journal: Sci Adv

PubMed ID: 34860542

Doi: 10.1126/sciadv.abj8156

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MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

Authors: Martin Houlard, Erin E Cutts, Muhammad S Shamim, Jonathan Godwin, David Weisz, Aviva Presser Aiden, Erez Lieberman-Aiden, Lothar Schermelleh, Kim Nasmyth, Alessandro Vannini

Journal: Elife

PubMed ID: 34850681

Doi: 10.7554/eLife.73348

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Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling

Authors: Yingrui Deng, Xiaoting Zhang, Rui Li, Zhuo Li, Boguang Yang, Peng Shi, Honglu Zhang, Chunming Wang, Chunyi Wen, Gang Li, Liming Bian

Journal: Biomaterials

PubMed ID: 34959028

Doi: 10.1016/j.biomaterials.2021.121316

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Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

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Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials

Authors: Jill Whitley, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, Hong Liao, Sean Chiou, Tina Marmura, Holly Zoeller, Ben Hudson, John Peart, Monica Johnson, Amelia Karlsson, Yunfei Wang, Cynthia Nagle, Cherell Harris, Daniel Tonkin, Stephanie Fraser, Lieza Capiz, Christina L Zeno, Yvonne Meli, Diana Martik, Daniel A Ozaki, Amy Caparoni, Jason E Dickens, Drew Weissman, Kevin O Saunders, Barton F Haynes, Gregory D Sempowski, Thomas N Denny, Matthew R Johnson

Journal: Transl Res

PubMed ID: 34871810

Doi: 10.1016/j.trsl.2021.11.009

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Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)

Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller

Journal: Biophys Chem

PubMed ID: 34953381

Doi: 10.1016/j.bpc.2021.106745

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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An immunochromatographic assay utilizing magnetic nanoparticles to detect major peanut allergen Ara h 1 in processed foods

Authors: Hsin-Yi Yin, Yi-Ting Li, Wen-Che Tsai, Hong-Yu Dai, Hsiao-Wei Wen

Journal: Food Chem

PubMed ID: 34952385

Doi: 10.1016/j.foodchem.2021.131844

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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver

Authors: Leire Goicoechea, Fabian Arenas, Fernanda Castro, Susana Nuñez, Sandra Torres, Carmen Garcia-Ruiz, José C Fernandez-Checa

Journal: STAR Protoc

PubMed ID: 35024626

Doi: 10.1016/j.xpro.2021.101068

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Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers

Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen

Journal: Hum Mutat

PubMed ID: 34923709

Doi: 10.1002/humu.24321

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Critical residues for proteolysis activity of maize chlorotic dwarf virus (MCDV) 3C-like protease and comparison of activity of orthologous waikavirus proteases

Authors: Lucy R Stewart, Matthew Willman, DeeMarie Marty, Anna Emmick Cole, Kristen Willie

Journal: Virology

PubMed ID: 34998226

Doi: 10.1016/j.virol.2021.12.008

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BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

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Targeting cIAPs attenuates CCl-induced liver fibrosis by increasing MMP9 expression derived from neutrophils

Authors: Yi Wu, Suwen Lu, Xuan Huang, Yuanyuan Liu, Kuiyuan Huang, Ziying Liu, Weikang Xu, Wei Zhu, Jinlin Hou, Hongyan Liu, Xiaoyong Zhang

Journal: Life Sci

PubMed ID: 34914932

Doi: 10.1016/j.lfs.2021.120235

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hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis

Authors: Pei Cao, Bo Ma, Ding Sun, Weigang Zhang, Junyi Qiu, Lei Qin, Xiaofeng Xue

Journal: Cancer Sci

PubMed ID: 34890089

Doi: 10.1111/cas.15238

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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Authors: Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Cathrine Knetter, Mete Can Odabasi, Ravi Chand Bollineni, Xinbo Yang, Zsofia Foldvari, Maxi-Lu Böschen, Eli Taraldsrud, Erlend Strønen, Mireille Toebes, Amy Hillen, Stefania Mazzi, Arnoud H de Ru, George M C Janssen, Arne Kolstad, Geir Erland Tjønnfjord, Benedicte A Lie, Marieke Griffioen, Sören Lehmann, Liv Toril Osnes, Jochen Buechner, K Christopher Garcia, Ton N Schumacher, Peter A van Veelen, Matthias Leisegang, Sten Eirik W Jacobsen, Petter Woll, Johanna Olweus

Journal: Nat Biotechno.

PubMed ID: 34873326

Doi: 10.1038/s41587-021-01089-x

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