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Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates

Authors: Marco Raabe, Astrid Johanna Heck, Siska Führer, Dominik Schauenburg, Michaela Pieszka, Tao Wang, Maksymilian Marek Zegota, Lutz Nuhn, David Y W Ng, Seah Ling Kuan, Tanja Weil

Journal: Macromol Biosci

PubMed ID: 34791790

Doi: 10.1002/mabi.202100299

Products & Services: Protein and Antibody Isolation

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

Authors: Juan Luis Pacheco-Garcia, Dmitry Loginov, Bruno Rizzuti, Pavla Vankova, Jose L Neira, Daniel Kavan, Noel Mesa-Torres, Rita Guzzi, Petr Man, Angel L Pey

Journal: FEBS Lett

PubMed ID: 34817874

Doi: 10.1002/1873-3468.14238

Products & Services: Gene Synthesis

Genomic structure, expression, and functional characterization of the Fem-1 gene family in the redclaw crayfish, Cherax quadricarinatus

Authors: Jianbo Zheng, Leran Chen, Yongyi Jia, Meili Chi, Fei Li, Shun Cheng, Shili Liu, Yinuo Liu, Zhimin Gu

Journal: Gen Comp Endocrinol

PubMed ID: 34861280

Doi: 10.1016/j.ygcen.2021.113961

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Commensal Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines

Authors: Michele Tomasi, Mattia Dalsass, Francesco Beghini, Ilaria Zanella, Elena Caproni, Laura Fantappiè, Assunta Gagliardi, Carmela Irene, Enrico König, Luca Frattini, Giulia Masetti, Samine Jessica Isaac, Federica Armanini, Fabio Cumbo, Aitor Blanco-Míguez, Alberto Grandi, Nicola Segata, Guido Grandi

Journal: Vaccines (Basel)

PubMed ID: 34835287

Doi: 10.3390/vaccines9111356

Products & Services: Peptide Synthesis

Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Authors: Martin J Fossat, Ammon E Posey, Rohit V Pappu

Journal: Biophys J

PubMed ID: 34826385

Doi: 10.1016/j.bpj.2021.11.2886

Products & Services: Peptide Synthesis

Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma

Authors: Ai-Ai Luan, Ling-Ling Hou, Fang-Yuan Zhang

Journal: Kaohsiung J Med Sci

PubMed ID: 34850542

Doi: 10.1002/kjm2.12479

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Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha

Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen

Journal: J Stroke Cerebrovasc Dis

PubMed ID: 34837757

Doi: 10.1016/j.jstrokecerebrovasdis.2021.106221

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The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells

Authors: Takwa S Aroankins, Sathish K Murali, Robert A Fenton, Qi Wu

Journal: Front Mol Biosci

PubMed ID: 34881291

Doi: 10.3389/fmolb.2021.790606

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Characterization of the interaction domains between the phosphoprotein and the nucleoprotein of human Metapneumovirus

Authors: Hortense Decool, Benjamin Bardiaux, Luis Checa Ruano, Olivier Sperandio, Jenna Fix, Irina Gutsche, Charles-Adrien Richard, Monika Bajorek, Jean-François Eléouët, Marie Galloux

Journal: J Virol

PubMed ID: 34730389

Doi: 10.1128/JVI.00909-21

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Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow

Authors: Kyong Hoon Kim, Aryeong Choi, Sang Hoon Kim, Heonju Song, Seohoon Jin, Kyungim Kim, Jaebong Jang, Hanbyeul Choi, Yong Woo Jung

Journal: Mol Cells

PubMed ID: 34819396

Doi: 10.14348/molcells.2021.0137

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Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia

Authors: Ting Zhu, Bo Liu, Di Wu, Gang Xu, Yang Fan

Journal: Front Cell Dev Biol

PubMed ID: 34869326

Doi: 10.3389/fcell.2021.740884

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Novel xylan-degrading enzymes from polysaccharide utilizing loci of Prevotella copri DSM18205

Authors: Javier A Linares-Pastén , Johan Sebastian Hero , José Horacio Pisa , Cristina Teixeira , Margareta Nyman , Patrick Adlercreutz , M Alejandra Martinez , Eva Nordberg Karlsson

Journal: Glycobiology

PubMed ID: 34142143

Doi: 10.1093/glycob/cwab056

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Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Authors: Marcel V Alavi

Journal: Biochim Biophys Acta Mol Cell Res.

PubMed ID: 34400172

Doi: 10.1016/j.bbamcr.2021.119116

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The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome

Authors: Yanqiu Yue, Fengbin Jin, Xiaohui Yue

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 34933712

Doi: 10.14715/cmb/2021.67.3.28

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SNHG17, as an EMT-related lncRNA, promotes the expression of c-Myc by binding to c-Jun in esophageal squamous cell carcinoma

Authors: Supeng Shen, Jia Liang, Xiaoliang Liang, Gaoyan Wang, Bo Feng, Wei Guo, Yanli Guo, Zhiming Dong

Journal: Cancer Sci

PubMed ID: 34714590

Doi: 10.1111/cas.15184

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Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket

Authors: Dinesh M Fernando, Clifford T Gee, Elizabeth C Griffith, Christopher J Meyer, Laura A Wilt, Rajendra Tangallapally, Miranda J Wallace, Darcie J Miller, Richard E Lee

Journal: Tuberculosis (Edinb)

PubMed ID: 34894561

Doi: 10.1016/j.tube.2021.102157

Products & Services: Bacterial Expression

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

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Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells

Authors: Wenjia Peng, Shuai Li, Shiyue Chen, Jiacheng Yang, Ze Sun

Journal: Front Cardiovasc Med

PubMed ID: 34912856

Doi: 10.3389/fcvm.2021.731890

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Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

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Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis

Authors: Annalisa Pianta, Geena Chiumento, Kristina Ramsden, Qi Wang, Klemen Strle, Sheila Arvikar, Catherine E Costello, Allen C Steere

Journal: Arthritis Rheumatol

PubMed ID: 34042327

Doi: 10.1002/art.41807

Products & Services: Bacterial Expression

Prior infection with SARS-CoV-2 boosts and broadens Ad26COV2S immunogenicity in a variant-dependent manner

Authors: Roanne Keeton, Simone I Richardson, Thandeka Moyo-Gwete, Tandile Hermanus, Marius B Tincho, Ntombi Benede, Nelia P Manamela, Richard Baguma, Zanele Makhado, Amkele Ngomti, Thopisang Motlou, Mathilda Mennen, Lionel Chinhoyi, Sango Skelem, Hazel Maboreke, Deelan Doolabh, Arash Iranzadeh, Ashley D Otter, Tim Brooks, Mahdad Noursadeghi, James C Moon, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Jonathan Blackburn, Nei-Yuan Hsiao, Carolyn Williamson, Catherine Riou, Ameena Goga, Nigel Garrett, Linda-Gail Bekker, Glenda Gray, Ntobeko A B Ntusi, Penny L Moore, Wendy A Burgers

Journal: Cell Host Microbe

PubMed ID: 34688376

Doi: 10.1016/j.chom.2021.10.003

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An inducible -Cre mouse model to monitor and manipulate -highly-expressing senescent cells

Authors: Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia, George A Kuchel, James L Kirkland, Ming Xu

Journal: Nat Aging

PubMed ID: 35024619

Doi: 10.1038/s43587-021-00107-6

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Drug Repurposing for the SARS-CoV-2 Papain-Like Protease

Authors: Chia-Chuan Cho, Shuhua G Li, Tyler J Lalonde, Kai S Yang, Ge Yu, Yuchen Qiao, Shiqing Xu, Wenshe Ray Liu

Journal: ChemMedChem

PubMed ID: 34423563

Doi: 10.1002/cmdc.202100455

Products & Services: Protein and Antibody Isolation

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo

Authors: Yuan Fang , Zezhong Liu , Yang Qiu , Jing Kong, Yuhong Fu, Yujie Liu , Chong Wang , Jia Quan , Qian Wang , Wei Xu , Lei Yin , Jie Cui , Yi Xu , Stephen Curry , Shibo Jiang , Lu Lu , Xi Zhou

Journal: Immunity

PubMed ID: 34555337

Doi: 10.1016/j.immuni.2021.08.027

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Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology

Authors: Xiaoyu Du, Yuqin Wang, Shanyu Zhang, Pingping Fan, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Anal Chem

PubMed ID: 34641671

Doi: 10.1021/acs.analchem.1c02775

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Guillain-Barré Syndrome Associated with COVID-19 Vaccination

Authors: Shih-Chieh Shao, Chien-Ho Wang, Kai-Cheng Chang, Ming-Jui Hung, Hui-Yu Chen, Shu-Chen Liao

Journal: Emerg Infect Dis

PubMed ID: 34648420

Doi: 10.3201/eid2712.211634

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Comparative transcriptome analysis uncovers cell wall reorganization and repressed cell division during cotton fiber initiation

Authors: Wenyuan Liu, Yanjia Lv, Xiaoyue Li, Zongqin Feng, Lichen Wang

Journal: BMC Dev Biol

PubMed ID: 34715791

Doi: 10.1186/s12861-021-00247-3

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Reprogramming the metabolism of PCC 6803 by regulating the plastoquinone biosynthesis

Authors: Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu

Journal: Synth Syst Biotechnol

PubMed ID: 34754966

Doi: 10.1016/j.synbio.2021.10.004

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A BK channel-targeted peptide induces age-dependent improvement in behavioral and neural sound representation

Authors: Elliott J Brecht, Luisa L Scott, Bo Ding, Xiaoxia Zhu, Joseph P Walton

Journal: Neurobiol Aging

PubMed ID: 34861480

Doi: 10.1016/j.neurobiolaging.2021.10.014

Products & Services: Protein and Antibody Isolation

Overexpression of the Ginkgo biloba WD40 gene GbLWD1-like improves salt tolerance in transgenic Populus

Authors: Yue Xin, Yaqiong Wu, Xin Han, Li-An Xu

Journal: Plant Sci

PubMed ID: 34763876

Doi: 10.1016/j.plantsci.2021.111092

Products & Services: Bacterial Expression

WSB1 regulates c-Myc expression through -catenin signaling and forms a feedforward circuit

Authors: Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao

Journal: Acta Pharm Sin B

PubMed ID: 35530152

Doi: 10.1016/j.apsb.2021.10.021

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The Bacterial Amyloids Phenol Soluble Modulins from Catalyze Alpha-Synuclein Aggregation

Authors: Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E Otzen, Sara Linse, Jia-Yi Li

Journal: Int J Mol Sci

PubMed ID: 34769023

Doi: 10.3390/ijms222111594

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Reconstitution of Caveolin-1 into Artificial Lipid Membrane: Characterization by Transmission Electron Microscopy and Solid-State Nuclear Magnetic Resonance

Authors: Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang

Journal: Molecules

PubMed ID: 34684779

Doi: 10.3390/molecules26206201

Products & Services: Bacterial Expression

Using Continuous Directed Evolution to Improve Enzymes for Plant Applications

Authors: Jorge D García-García, Kristen Van Gelder, Jaya Joshi, Ulschan Bathe, Bryan J Leong, Steven D Bruner, Chang C Liu, Andrew D Hanson

Journal: Plant Physiol

PubMed ID: 34718794

Doi: 10.1093/plphys/kiab500

Products & Services: Recombinant Antibody Expression

Ethylene Induced by Sound Stimulation Enhances Anthocyanin Accumulation in Grape Berry Skin through Direct Upregulation of UDP-Glucose: Flavonoid 3--Glucosyltransferase

Authors: Mone Yamazaki, Akari Ishida, Yutaka Suzuki, Yoshinao Aoki, Shunji Suzuki, Shinichi Enoki

Journal: Cells

PubMed ID: 34685779

Doi: 10.3390/cells10102799

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Polymersomes as Stable Nanocarriers for a Highly Immunogenic and Durable SARS-CoV-2 Spike Protein Subunit Vaccine

Authors: Jian Hang Lam, Amit K Khan, Thomas A Cornell, Teck Wan Chia, Regine J Dress, Wen Wang William Yeow, Nur Khairiah Mohd-Ismail, Shrinivas Venkataraman, Kim Tien Ng, Yee-Joo Tan, Danielle E Anderson, Florent Ginhoux, Madhavan Nallani

Journal: ACS Nano

PubMed ID: 34618423

Doi: 10.1021/acsnano.1c01243

Products & Services: Recombinant Antibody Expression

Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus

Authors: Oscar A Ortega-Rivera, Sourabh Shukla, Matthew D Shin, Angela Chen, Veronique Beiss, Miguel A Moreno-Gonzalez, Yi Zheng, Alex E Clark, Aaron F Carlin, Jonathan K Pokorski, Nicole F Steinmetz

Journal: ACS Infect Dis

PubMed ID: 34672530

Doi: 10.1021/acsinfecdis.1c00410

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Recombinant expression of insoluble enzymes in Escherichia coli: a systematic review of experimental design and its manufacturing implications

Authors: Suraj Mital, Graham Christie, Duygu Dikicioglu

Journal: Microb Cell Fact

PubMed ID: 34717620

Doi: 10.1186/s12934-021-01698-w

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Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response

Authors: Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir

Journal: PLoS Pathog

PubMed ID: 34653226

Doi: 10.1371/journal.ppat.1010007

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Enzymatic extraction improves intracellular protein recovery from the industrial carrageenan seaweed revealed by quantitative, subcellular protein profiling: A high potential source of functional food ingredients

Authors: Simon Gregersen, Anne-Sofie Havgaard Kongsted, Rikke Brønnum Nielsen, Søren Storck Hansen, Frederik Andersen Lau, Jacob Bisgaard Rasmussen, Susan Løvstad Holdt, Charlotte Jacobsen

Journal: Food Chem X

PubMed ID: 34746746

Doi: 10.1016/j.fochx.2021.100137

Products & Services: Protein and Antibody Isolation

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom

Journal: biorxiv

PubMed ID: 34671768

Doi: 10.1101/2021.10.12.464114

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Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators

Authors: Luisa Vernizzi, Christian F Lehner

Journal: PLoS Genet

PubMed ID: 34669718

Doi: 10.1371/journal.pgen.1009870

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Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Authors: Hillary H Le, Suleyman S Cinaroglu, Elise C Manalo, Aysegul Ors, Michelle M Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A Origel Marmolejo, Arnaud Quentel, Justin S Plaut, Taryn E Kawashima, E Sila Ozdemir, Sanjay V Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C Saldivar, Emel Timucin, Jared M Fischer

Journal: EBioMedicine

PubMed ID: 34689087

Doi: 10.1016/j.ebiom.2021.103646

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Stabilized coronavirus spike stem elicits a broadly protective antibody

Authors: Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Jory A Goldsmith, Chia-Wei Chou, Olubukola M Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J Fritch, Kenneth H Dinnon, Alexandra Schäfer, Mark R Denison, James D Chappell, Ralph S Baric, Barney S Graham, Kizzmekia S Corbett, Jason S McLellan

Journal: Cell Rep

PubMed ID: 34710354

Doi: 10.1016/j.celrep.2021.109929

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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins

Authors: Kristina V Boyko, Erin A Rosenkranz, Derrick M Smith, Heather L Miears, Melissa Oueld Es Cheikh, Micah Z Lund, Jeffery C Young, Patrick N Reardon, Mark Okon, Serge L Smirnov, John M Antos

Journal: PLoS ONE

PubMed ID: 34710113

Doi: 10.1371/journal.pone.0258531

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Authors: Jazmine P Hallinan, Lindsey A Doyle, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

Journal: Commun Biol

PubMed ID: 34716407

Doi: 10.1038/s42003-021-02766-y

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Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway

Authors: Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu

Journal: Evid Based Complement Alternat Med

PubMed ID: 34646326

Doi: 10.1155/2021/5561999

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Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies

Authors: Andrew T Chen, Hannah D Stacey, Art Marzok, Pardeep Singh, Jann Ang, Matthew S Miller, Mark Loeb

Journal: Vaccine

PubMed ID: 34756613

Doi: 10.1016/j.vaccine.2021.10.021

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Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

Journal: Biol Direct

PubMed ID: 34674770

Doi: 10.1186/s13062-021-00305-7

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Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang, Sheng Zhang

Journal: Cancer Cell Int

PubMed ID: 34663350

Doi: 10.1186/s12935-021-02257-4

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High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1

Authors: Xiaoli Tang, Xiaogang Ye, Xiaoxiao Wang, Shuo Zhao, Meiyu Wu, Jinghua Ruan, Boxiong Zhong

Journal: Sci Rep

PubMed ID: 34697320

Doi: 10.1038/s41598-021-00029-8

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Robust Neutralizing Antibody Responses 6 Months Post Vaccination with BNT162b2: A Prospective Study in 308 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sentiljana Gumeni, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Life (Basel)

PubMed ID: 34685448

Doi: 10.3390/life11101077

Characterization of oleosin genes from forage sorghum in Arabidopsis and yeast reveals their role in storage lipid stability

Authors: Rabishankar Ojha, Simranjit Kaur, Kshitija Sinha, Kirti Chawla, Sumandeep Kaur, Harish Jadhav, Manmehar Kaur, Rupam Kumar Bhunia

Journal: Planta

PubMed ID: 34655341

Doi: 10.1007/s00425-021-03744-8

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Zinc Influx Restricts Enterovirus D68 Replication

Authors: Shunan Liu, Xia Cao, Haoran Guo, Wei Wei

Journal: Front Microbiol

PubMed ID: 34721351

Doi: 10.3389/fmicb.2021.748546

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Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors

Authors: Michalis Liontos, Evangelos Terpos, Christos Markellos, Flora Zagouri, Alexandros Briasoulis, Ioanna Katsiana, Efthymia Skafida, Oraianthi Fiste, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34696256

Doi: 10.3390/vaccines9101148

Surrogate test performance for SARS-CoV-2 neutralizing antibodies (nAbs) for convalescent plasma (CCP): How useful could they be?

Authors: Silvano Wendel, Roberta Fachini, Rita C L Fontão-Wendel, Ralyria Mello, Carlos Vinícius Velasquez, Rafael Rahal Guaragna Machado, Mayra Altobelli Brito, Marcelo Amaral, Camila Pereira Soares, Ruth Achkar, Patrícia Scuracchio, Sandra Cristina Miyaji, Melina Santos Erdens, Edison Luiz Durigon

Journal: Transfusion

PubMed ID: 34674284

Doi: 10.1111/trf.16714

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Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: medrxiv

PubMed ID: 34729569

Doi: 10.1101/2021.10.27.21265561

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Comparing Five SARS-CoV-2 Antibody Assay Results Before and After the First and Second ChAdOx1 nCoV-19 Vaccination Among Health Care Workers: A Prospective Multicenter Study

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34613799

Doi: 10.1128/JCM.01788-21

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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Authors: Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan

Journal: Sci Transl Med

PubMed ID: 34519517

Doi: 10.1126/scitranslmed.abj5413

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SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

Authors: Maoquan Li, Jinqiu Ning, Jiwei Wang, Qiqian Yan, Ke Zhao, Xiaoshi Jia

Journal: Int J Mol Med

PubMed ID: 34617577

Doi: 10.3892/ijmm.2021.5043

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Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Authors: Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B Sanz-Martos, Francisco Zafra

Journal: Cell Mol Life Sci

PubMed ID: 34709416

Doi: 10.1007/s00018-021-03998-1

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Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Authors: Guha Asthagiri Arunkumar, Disha Bhavsar, Tiehai Li, Shirin Strohmeier, Veronika Chromikova, Fatima Amanat, Mehman Bunyatov, Patrick C Wilson, Ali H Ellebedy, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Florian Krammer

Journal: Nat Commun

PubMed ID: 34697321

Doi: 10.1038/s41467-021-26409-2

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Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway

Authors: Xin Lin, Yong Zhu, Guohui Le

Journal: J Interferon Cytokine Res

PubMed ID: 34698528

Doi: 10.1089/jir.2021.0083

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Characterization of From the Marine Crab and Its Functions Under Low Salinity Conditions

Authors: Xianyun Ren, Lei Wang, Yao Xu, Qiong Wang, Jianjian Lv, Ping Liu, Jian Li

Journal: Front Physiol

PubMed ID: 34744765

Doi: 10.3389/fphys.2021.724693

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Metabolic Engineering of for Improved 2,3-Butanediol Production by Manipulating NADH Levels and Overexpressing the Small RNA RyhB

Authors: Yan Wu, Wanying Chu, Jiayao Yang, Yudong Xu, Qi Shen, Haoning Yang, Fangxu Xu, Yefei Liu, Ping Lu, Ke Jiang, Hongxin Zhao

Journal: Front Microbiol

PubMed ID: 34691005

Doi: 10.3389/fmicb.2021.754306

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The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice

Authors: Guendalina Zaccaria, Daniela Malatesta, Lucija Jurisic, Maurilia Marcacci, Giovanni Di Teodoro, Annamaria Conte, Liana Teodori, Federica Monaco, Valeria Marini, Claudia Casaccia, Giovanni Savini, Annapia Di Gennaro, Emanuela Rossi, Vincenzo D'Innocenzo, Nicola D'Alterio, Alessio Lorusso

Journal: Vet Microbiol

PubMed ID: 34715462

Doi: 10.1016/j.vetmic.2021.109262

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Novel Phage-Derived Depolymerase with Activity against Biofilms

Authors: Cormac J Rice, Stephen A Kelly, Seamus C O'Brien, Erinn M Melaugh, Jan C B Ganacias, Zheng Hua Chai, Brendan F Gilmore, Timofey Skvortsov

Journal: Microorganisms

PubMed ID: 34683494

Doi: 10.3390/microorganisms9102172

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Regulate the hydrophobic motif to enhance the non-classical secretory expression of Pullulanase PulA in Bacillus subtilis

Authors: Jie Zhen, Hongchen Zheng, Xingya Zhao, Xiaoping Fu, Shibin Yang, Jianyong Xu, Hui Song, Yanhe Ma

Journal: Int J Biol Macromol

PubMed ID: 34710472

Doi: 10.1016/j.ijbiomac.2021.10.164

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Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Authors: Kazuhiro Kobuke, Kenji Oki, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez, Kiyotaka Itcho, Haruya Ohno, Gaku Nagano, Yoko Yoshii, Ryuta Baba, Takaya Kodama, Koji Arihiro, Noboru Hattori, Masayasu Yoneda

Journal: Int J Mol Sci

PubMed ID: 34681640

Doi: 10.3390/ijms222010981

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Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel

Authors: Ying Wang, Yi-Chi Zhang, Ke-Xin Zhang, Zhong-Qiang Jia, Tao Tang, Lin-Lin Zheng, Di Liu, Chun-Qing Zhao

Journal: Pest Manag Sci

PubMed ID: 34619015

Doi: 10.1002/ps.6669

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FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2

Authors: Jenna M DeLuca, Maegan K Murphy, Xin Wang, Timothy J Wilson

Journal: J Immunol

PubMed ID: 34697226

Doi: 10.4049/jimmunol.2100218

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Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Authors: Vincent Dussupt, Rajeshwer S Sankhala, Letzibeth Mendez-Rivera, Samantha M Townsley, Fabian Schmidt, Lindsay Wieczorek, Kerri G Lal, Gina C Donofrio, Ursula Tran, Nathaniel D Jackson, Weam I Zaky, Michelle Zemil, Sarah R Tritsch, Wei-Hung Chen, Elizabeth J Martinez, Aslaa Ahmed, Misook Choe, William C Chang, Agnes Hajduczki, Ningbo Jian, Caroline E Peterson, Phyllis A Rees, Magdalena Rutkowska, Bonnie M Slike, Christopher N Selverian, Isabella Swafford, I-Ting Teng, Paul V Thomas, Tongqing Zhou, Clayton J Smith, Jeffrey R Currier, Peter D Kwong, Morgane Rolland, Edgar Davidson, Benjamin J Doranz, Christopher N Mores, Theodora Hatziioannou, William W Reiley, Paul D Bieniasz, Dominic Paquin-Proulx, Gregory D Gromowski, Victoria R Polonis, Nelson L Michael, Kayvon Modjarrad, M Gordon Joyce, Shelly J Krebs

Journal: Nat Immunol

PubMed ID: 34716452

Doi: 10.1038/s41590-021-01068-z

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Identification and characterization of arginine kinase, a novel allergen that causes cross-reactivity among shellfish

Authors: Fei Huan, Tian-Jiao Han, Meng Liu, Meng-Si Li, Yang Yang, Qing-Mei Liu, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: Food Funct

PubMed ID: 34664604

Doi: 10.1039/d1fo02042k

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The selective degradation of sirtuins via macroautophagy in the MPP model of Parkinson's disease is promoted by conserved oxidation sites

Authors: Marius W Baeken, Mario Schwarz, Andreas Kern, Bernd Moosmann, Parvana Hajieva, Christian Behl

Journal: Cell Death Discov

PubMed ID: 34642296

Doi: 10.1038/s41420-021-00683-x

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Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence

Authors: Hillary A Vanderven, Robyn Esterbauer, Sinthujan Jegaskanda, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent

Journal: Immunol Cell Biol

PubMed ID: 34687553

Doi: 10.1111/imcb.12508

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Ultrasensitive Detection of SARS-CoV-2 Spike Proteins Using the Thio-NAD Cycling Reaction: A Preliminary Study before Clinical Trials

Authors: Yuta Kyosei, Mayuri Namba, Daiki Makioka, Ayumi Kokubun, Satoshi Watabe, Teruki Yoshimura, Tadahiro Sasaki, Tatsuo Shioda, Etsuro Ito

Journal: Microorganisms

PubMed ID: 34835340

Doi: 10.3390/microorganisms9112214

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Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation

Authors: Mounira Chalabi-Dchar, Elisabeth Cruz, Hichem C Mertani, Jean-Jacques Diaz, José Courty, Ilaria Cascone, Philippe Bouvet

Journal: Cancers (Basel)

PubMed ID: 34638443

Doi: 10.3390/cancers13194957

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Overexpression of a carrot BCH gene, DcBCH1, improves tolerance to drought in Arabidopsis thaliana

Authors: Tong Li, Jie-Xia Liu, Yuan-Jie Deng, Zhi-Sheng Xu, Ai-Sheng Xiong

Journal: BMC Plant Biol

PubMed ID: 34663216

Doi: 10.1186/s12870-021-03236-7

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Structural and allergenic properties of the Fatty Acid Binding Protein from shrimp Litopenaeus vannamei

Authors: Marlon Múnera, Dalgys Martínez, Judith Wortmann, Josefina Zakzuk, Walter Keller, Luis Caraballo, Leonardo Puerta

Journal: Allergy

PubMed ID: 34695231

Doi: 10.1111/all.15154

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Efficient Multi-Sites Genome Editing and Plant Regeneration Somatic Embryogenesis in

Authors: Ying Cui, Jian Zhao, Ying Gao, Ruirui Zhao, Jinfeng Zhang, Lisheng Kong

Journal: Front Plant Sci

PubMed ID: 34721480

Doi: 10.3389/fpls.2021.751891

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PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Authors: Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 34718369

Doi: 10.1093/abbs/gmab143

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Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome

Authors: Amanda Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, Pilar Gonzalo, María J Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R Hamczyk, Álvaro Macías, Lara Del Campo, Emilio Camafeita, Jesús Vázquez, Anna Barkaway, Loïc Rolas, Sussan Nourshargh, Beatriz Dorado, Ignacio Benedicto, Vicente Andrés

Journal: Circulation

PubMed ID: 34694158

Doi: 10.1161/CIRCULATIONAHA.121.055313

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The ubiquitous buried water in the beta-trefoil architecture contributes to the folding nucleus and ~20% of the folding enthalpy

Authors: Joseph B Parker, Connie A Tenorio, Michael Blaber

Journal: Protein Sci

PubMed ID: 34562298

Doi: 10.1002/pro.4192

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Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector

Authors: Michiel van Diepen, Rosamund Chapman, Nicola Douglass, Leah Whittle, Nicole Chineka, Shireen Galant, Christian Cotchobos, Akiko Suzuki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34696239

Doi: 10.3390/vaccines9101131

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A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Authors: Kellan T Passow, Haley S Caldwell, Kiet A Ngo, Jamie J Arnold, Nicole M Antczak, Anoop Narayanan, Joyce Jose, Shana J Sturla, Craig E Cameron, Alexander T Ciota, Daniel A Harki

Journal: J Med Chem

PubMed ID: 34661397

Doi: 10.1021/acs.jmedchem.1c01481

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Mutational analysis of TlyA from Brachyspira hampsonii reveals two key residues conserved in pathogenic bacteria responsible for oligomerization and hemolytic activity

Authors: Brandon A Keith, John C S Harding, Matthew E Loewen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34715264

Doi: 10.1016/j.bbagen.2021.130045

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Repeating Aspartic Acid Residues Prefer Turn-like Conformations in the Unfolded State: Implications for Early Protein Folding

Authors: Bridget Milorey, Harald Schwalbe, Nichole O'Neill, Reinhard Schweitzer-Stenner

Journal: J Phys Chem B

PubMed ID: 34619031

Doi: 10.1021/acs.jpcb.1c06472

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Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures

Authors: Supriya Ravichandran, Gabrielle Grubbs, Juanjie Tang, Youri Lee, Chang Huang, Hana Golding, Surender Khurana

Journal: Sci Adv

PubMed ID: 34644111

Doi: 10.1126/sciadv.abi6533

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Synthetic virology: the experts speak

Authors:

Journal: Nat Biotechnol

PubMed ID: 34599304

Doi: 10.1038/s41587-021-01078-0

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Generation of recombinant vaccinia virus and analysis of virus-induced cell death

Authors: Zhijun Liu, Kidong Kang, Francis Ka-Ming Chan

Journal: STAR Protoc

PubMed ID: 34661172

Doi: 10.1016/j.xpro.2021.100871

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Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period

Authors: Wen-Heng Ji, Dan-Dan Li, Dan-Ping Wei, Ai-Qin Gu, Ying Yang, Jing-Pian Peng

Journal: Front Immunol

PubMed ID: 34712245

Doi: 10.3389/fimmu.2021.763067

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ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Authors: Hao Zhong, Jian Wang, Muhammad Adnan Hafeez, Rongfa Guan, Fengqin Feng

Journal: Front Nutr

PubMed ID: 34805244

Doi: 10.3389/fnut.2021.754222

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Natural diversity provides a broad spectrum of cyanobacteriochrome-based diguanylate cyclases

Authors: Matthew Blain-Hartung, Nathan C Rockwell, J Clark Lagarias

Journal: Plant Physiol

PubMed ID: 34608946

Doi: 10.1093/plphys/kiab240

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Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation

Authors: Aneta J Lenard, Saskia Hutten, Qishun Zhou, Sinem Usluer, Fangrong Zhang, Benjamin M R Bourgeois, Dorothee Dormann, Tobias Madl

Journal: Front Mol Biosci

PubMed ID: 34738012

Doi: 10.3389/fmolb.2021.689687

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Human serum albumin fusion protein as therapeutics for targeting amyloid beta in Alzheimer's diseases

Authors: Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, Kwan Hee Lee

Journal: Neurosci Lett

PubMed ID: 34673147

Doi: 10.1016/j.neulet.2021.136298

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Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection

Authors: Yin Liu, Yanling Chen, Shisheng Huang, Xiaodong Ma, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Frontiers

Doi: 10.3389/fmolb.2021.753276

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Design of a synthesis-friendly hypoxia-responsive promoter for cell-based therapeutics

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Eng Life Sci

PubMed ID: 34899121

Doi: 10.1002/elsc.202100045

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