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miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway

Authors: Qingping Song, Hui Liu, Chengyan Li, Haifeng Liang

Journal: Aging (Albany NY)

PubMed ID: 34426559

Doi: 10.18632/aging.203430

Products & Services: Custom DNA/RNA Oligos

Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

Products & Services: Plasmid DNA Preparation

Genome Editing in Zebrafish by ScCas9 Recognizing NNG PAM

Authors: Yunxing Liu , Fang Liang , Zijiong Dong , Song Li , Jianmin Ye and Wei Qin

Journal: Cells

PubMed ID: 34440868

Doi: 10.3390/cells10082099

Products & Services: Gene Services

Subtype-selective positive modulation of K Ca 2 channels depends on the HA/HB helices

Authors: Young-Woo Nam，Meng Cui， Naglaa Salem，Razan Orfali，Misa Nguyen， Grace Yang，Mohammad Asikur Rahman， Judy Lee，Miao Zhang

Journal: British Journal of Pharmacol

PubMed ID: 34458981

Doi: 10.1111/bph.15676

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Comparability of six different immunoassays measuring SARS-CoV-2 antibodies with neutralizing antibody levels in convalescent plasma: From utility to prediction

Authors: Abigail Lamikanra, Dung Nguyen, Peter Simmonds, Sarah Williams, Emma M Bentley, Cathy Rowe, Ashley David Otter, Tim Brooks, Kimberly Gilmour, Annabelle Mai, Jusvinder Dadhra, Mabel Csatari, Sheba Ziyenge, Marta Oliveira, Rutger Ploeg, Pat Tsang, Maria Zambon, Robin Gopal, Julie Huiyuan Xiao, Alain Townsend, David Roberts, Heli Harvala

Journal: Transfusion

PubMed ID: 34342366

Doi: 10.1111/trf.16600

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Light-Induced Dynamic Change of Phytochrome B and Cryptochrome 1 Stabilizes SINATs in

Authors: Jin Hu, Yinmeng Hu, Mengran Yang, Xiaotong Hu, Xuelu Wang

Journal: Front Plant Sci

PubMed ID: 34490020

Doi: 10.3389/fpls.2021.722733

Products & Services: Proteins, Expression, Isolation and Analysis

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

Authors: Amanda J Morris, Lindsay Jackson, Yvonne Cw Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M Guttman, P Lynne Howell, Matthew R Parsek, Lucas R Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S Guttman, Daniel J Wozniak, Valerie J Waters

Journal: NPJ Biofilms Microbiomes

PubMed ID: 34349133

Doi: 10.1038/s41522-021-00234-3

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinase polymerase amplification (RPA) with lateral flow detection for three Anaplasma species of importance to livestock health

Authors: Andrea Salazar, Francisco M Ochoa-Corona, Justin L Talley, Bruce H Noden

Journal: Sci Rep

PubMed ID: 34354122

Doi: 10.1038/s41598-021-95402-y

Products & Services: Proteins, Expression, Isolation and Analysis

CD27 expression on Treg cells limits immune responses against tumors

Authors: Sabine Muth, Annekatrin Klaric, Markus Radsak, Hansjörg Schild, Hans Christian Probst

Journal: J Mol Med (Berl)

PubMed ID: 34423375

Doi: 10.1007/s00109-021-02116-9

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A Novel microRNA of Japanese Flounder Regulates Antimicrobial Immunity Involving a Bacteria-Binding CSF3

Authors: Wenrui Li, Xiaolu Guan, Bin Sun, Li Sun

Journal: Front Immunol

PubMed ID: 34489973

Doi: 10.3389/fimmu.2021.723401

Products & Services: Plasmid DNA Preparation

Molecular architecture and modifications of full-length myocilin

Authors: Mackenzie D Martin, Dustin J E Huard, Ricardo C Guerrero-Ferreira, Ishani M Desai, Brett M Barlow, Raquel L Lieberman

Journal: Exp Eye Res

PubMed ID: 34400147

Doi: 10.1016/j.exer.2021.108729

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Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells

Authors: Tingting Xu, Madison Gilliam, Gary Sayler, Steven Ripp, Dan Close

Journal: BioTechniques

PubMed ID: 34350768

Doi: 10.2144/btn-2021-0017

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TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis

Authors: Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao

Journal: Inflamm Res

PubMed ID: 34374795

Doi: 10.1007/s00011-021-01490-x

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Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

Authors: Ethan W Hass, Zachary A Sorrentino, Yuxing Xia, Grace M Lloyd, John Q Trojanowski, Stefan Prokop, Benoit I Giasson

Journal: Acta Neuropathol Commun

PubMed ID: 34454615

Doi: 10.1186/s40478-021-01242-2

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Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern

Authors: Thorben Sprink, Frank Hartung

Journal: Int J Mol Sci

PubMed ID: 34502253

Doi: 10.3390/ijms22179346

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Porcine Epidemic Diarrhea Virus Inhibits HDAC1 Expression To Facilitate Its Replication via Binding of Its Nucleocapsid Protein to Host Transcription Factor Sp1

Authors: Jidong Xu, Junyong Mao, Xiao Han, Fushan Shi, Qin Gao, Tingjun Wang, Zhenning Zhang, Ying Shan, Weihuan Fang, Xiaoliang Li

Journal: J Virol

PubMed ID: 34232065

Doi: 10.1128/JVI.00853-21

Products & Services: PCR Cloning and Subcloning

Sex Differences in the Hypothalamic Oxytocin Pathway to Locus Coeruleus and Augmented Attention with Chemogenetic Activation of Hypothalamic Oxytocin Neurons

Authors: Xin Wang, Joan B Escobar, David Mendelowitz

Journal: Int J Mol Sci

PubMed ID: 34445224

Doi: 10.3390/ijms22168510

Products & Services: PCR Cloning and Subcloning

Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies

Authors: Hai Trong Nguyen, Darryl Falzarano, Volker Gerdts, Qiang Liu

Journal: J Virol

PubMed ID: 34191580

Doi: 10.1128/JVI.00687-21

Products & Services: PCR Cloning and Subcloning

Construction and preservation of a stable and highly expressed recombinant Helicobacter pylori vacuolating cytotoxin A with apoptotic activity

Authors: Ling-Zhi Yuan, Xiao Shi, Dan Tang, Shao-Peng Zheng, Zhi-Ming Xiao, Fen Wang

Journal: BMC Microbiol

PubMed ID: 34407768

Doi: 10.1186/s12866-021-02262-7

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MiR-199b-5p Promotes Gastric Cancer Progression by Regulating HHIP Expression

Authors: Songda Chen, Huijie Wu, Lingyu Zhu, Mengjie Jiang, Shuli Wei, Jinhua Luo, Aiqun Liu

Journal: Front Oncol

PubMed ID: 34532291

Doi: 10.3389/fonc.2021.728393

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

Authors: Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P Bates, Daniel Aeschlimann, Joan S Steffan, Stephan von Hörsten

Journal: Int J Mol Sci

PubMed ID: 34445621

Doi: 10.3390/ijms22168914

Products & Services: Mutant Libraries

Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide

Authors: Shanjana Awasthi, Gaurav Kumar, Vijay Ramani, Vibhudutta Awasthi, Karla K Rodgers, Jun Xie, Jacob Beierle, Gertrude Kyere-Davies, Bhupinder Singh, Negar Rahman, Asif Alam Chowdhury, Neha Chataut

Journal: Immunohorizons

PubMed ID: 34429343

Doi: 10.4049/immunohorizons.2100067

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Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction

Authors: Armando Estrada, Alejandro C Rodriguez, Georgialina Rodriguez, Alice H Grant, Yoshira M Ayala-Marin, Amy J Arrieta, Robert A Kirken

Journal: Sci Rep

PubMed ID: 34417497

Doi: 10.1038/s41598-021-96428-y

Products & Services: Mammalian Expression

Circular RNA FNDC3B Protects Oral Squamous Cell Carcinoma Cells From Ferroptosis and Contributes to the Malignant Progression by Regulating miR-520d-5p/SLC7A11 Axis

Authors: Jie Yang, Xing-Hua Cao, Ke-Feng Luan, Yun-Dong Huang

Journal: Front Oncol

PubMed ID: 34434890

Doi: 10.3389/fonc.2021.672724

Products & Services: Mammalian Expression

A Widespread Bacterial Secretion System with Diverse Substrates

Authors: Alex S Grossman, Terra J Mauer, Katrina T Forest, Heidi Goodrich-Blair

Journal: MBio.

PubMed ID: 34399622

Doi: 10.1128/mBio.01956-21

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Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor

Authors: Kim Ghilarducci, Valérie C Cabana, Camille Desroches, Kahina Chabi, Steve Bourgault, Laurent Cappadocia, Marc P Lussier

Journal: FEBS J

PubMed ID: 33650289

Doi: 10.1111/febs.15796

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Live-cell imaging of microRNA expression with post-transcriptional feedback control

Authors: Masayuki Sano, Kana Morishita, Satoshi Oikawa, Takayuki Akimoto, Kimio Sumaru, Yoshio Kato

Journal: Mol Ther Nucleic Acids

PubMed ID: 34631284

Doi: 10.1016/j.omtn.2021.08.018

Products & Services: Mammalian Expression

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin

Authors: Adriana E Galván, Ngozi P Paul, Jian Chen, Kunie Yoshinaga-Sakurai, Sagar M Utturkar, Barry P Rosen, Masafumi Yoshinaga

Journal: Microbiol Spectr

PubMed ID: 34378964

Doi: 10.1128/Spectrum.00502-21

Products & Services: Mammalian Expression

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Authors: Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu

Journal: Signal Transduct Target Ther

PubMed ID: 34408131

Doi: 10.1038/s41392-021-00726-w

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Aptamer-Integrated Scaffolds for Biologically Functional DNA Origami Structures

Authors: Xiaoxing Chen, Bin Jia, Zhangwei Lu, Libing Liao, Hanyang Yu, Zhe Li

Journal: ACS Appl Mater Interfaces

PubMed ID: 34402304

Doi: 10.1021/acsami.1c09307

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Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid

Authors: Jae Ho Shin, Aaron John Christian Andersen, Puck Achterberg, Lisbeth Olsson

Journal: Microb Cell Fact

PubMed ID: 34348702

Doi: 10.1186/s12934-021-01647-7

Products & Services: Gene Synthesis

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice

Authors: Arshad Khan, Ekramy E Sayedahmed, Vipul K Singh, Abhishek Mishra, Stephanie Dorta-Estremera, Sita Nookala, David H Canaday, Min Chen, Jin Wang, K Jagannadha Sastry, Suresh K Mittal, Chinnaswamy Jagannath

Journal: Cell Rep Med

PubMed ID: 34467249

Doi: 10.1016/j.xcrm.2021.100372

Products & Services: Gene Synthesis

Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from

Authors: Geunyeong Kim, Minhwa Hong, Ayesha Kashif, Yujin Hong, Beom-Seok Park, Ji-Young Mun, Hyosun Choi, Ji-Sook Lee, Eun-Ju Yang, Ran-Sook Woo, Soo-Jin Lee, Minseo Yang, In-Sik Kim

Journal: Int J Mol Sci

PubMed ID: 34445142

Doi: 10.3390/ijms22168440

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Decisive Effects of Life Stage on the Gut Microbiota Discrepancy Between Two Wild Populations of Hibernating Asiatic Toads ()

Authors: Xiaowei Song, Jingwei Zhang, Jinghan Song, Yuanyuan Zhai

Journal: Front Microbiol

PubMed ID: 34413833

Doi: 10.3389/fmicb.2021.665849

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Functionalizing Cell-Free Systems with CRISPR-Associated Proteins: Application to RNA-Based Circuit Engineering

Authors: François-Xavier Lehr, Alina Kuzembayeva, Megan E Bailey, Werner Kleindienst, Johannes Kabisch, Heinz Koeppl

Journal: ACS Synth Biol

PubMed ID: 34383464

Doi: 10.1021/acssynbio.0c00386

Products & Services: DNA Sequencing

Development of a real-time recombinase-aided amplification (RT-RAA) molecular diagnosis assay for sensitive and rapid detection of Toxoplasma gondii

Authors: Zhao-Hua Wang, Wei Zhang, Xiu-Zhong Zhang, Xin-Ran Yao, Wei Huang, Hong Jia, Xiao-Lei Liu, Shao-Hua Hou, Xiao-Jia Wang

Journal: Vet Parasitol

PubMed ID: 34384956

Doi: 10.1016/j.vetpar.2021.109489

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Engineering entropy-driven based multiple signal amplification strategy for visualized assay of miRNA by naked eye

Authors: Sha Zhu, Yi Qi Yang, Yuedi Ding, Ninghan Feng, Menglu Li, Yongmei Yin

Journal: Talanta

PubMed ID: 34517667

Doi: 10.1016/j.talanta.2021.122810

Products & Services: DNA Sequencing

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease

Authors: Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng, Huanhuan Jin

Journal: Cell Prolif

PubMed ID: 34346124

Doi: 10.1111/cpr.13107

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MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4

Authors: Ping Fan, Likun Zhang, Tianyu Cheng, Jing Wang, Junyun Zhou, Li Zhao, Cuie Hua, Quan Xia

Journal: J Mol Histol

PubMed ID: 34406553

Doi: 10.1007/s10735-021-10009-x

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A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Authors: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan

Journal: Nat Commun

PubMed ID: 34404805

Doi: 10.1038/s41467-021-25331-x

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Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo

Authors: Shaohui Wang, Ujjaldeep Jaggi, Jack Yu, Homayon Ghiasi

Journal: PLoS Pathog

PubMed ID: 34352042

Doi: 10.1371/journal.ppat.1009848

Products & Services: DNA Sequencing

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Authors: Juliana C Ferreira, Samar Fadl, Metehan Ilter, Hanife Pekel, Rachid Rezgui, Ozge Sensoy, Wael M Rabeh

Journal: FASEB J

PubMed ID: 34324734

Doi: 10.1096/fj.202100994

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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

Authors: Serdar Durdagi, Çağdaş Dağ, Berna Dogan, Merve Yigin, Timucin Avsar, Cengizhan Buyukdag, Ismail Erol, Fatma Betul Ertem, Seyma Calis, Gunseli Yildirim, Muge D Orhan, Omur Guven, Busecan Aksoydan, Ebru Destan, Kader Sahin, Sabri O Besler, Lalehan Oktay, Alaleh Shafiei, Ilayda Tolu, Esra Ayan, Busra Yuksel, Ayse B Peksen, Oktay Gocenler, Ali D Yucel, Ozgur Can, Serena Ozabrahamyan, Alpsu Olkan, Ece Erdemoglu, Fulya Aksit, Gokhan Tanisali, Oleksandr M Yefanov, Anton Barty, Alexandra Tolstikova, Gihan K Ketawala, Sabine Botha, E Han Dao, Brandon Hayes, Mengning Liang, Matthew H Seaberg, Mark S Hunter, Alex Batyuk, Valerio Mariani, Zhen Su, Frederic Poitevin, Chun Hong Yoon, Christopher Kupitz, Raymond G Sierra, Edward H Snell, Hasan DeMirci

Journal: Structure

PubMed ID: 34403647

Doi: 10.1016/j.str.2021.07.007

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An epigenetic basis of inbreeding depression in maize

Authors: Tongwen Han, Fang Wang, Qingxin Song, Wenxue Ye, Tieshan Liu, Liming Wang, Z Jeffrey Chen

Journal: Sci Adv

PubMed ID: 34452913

Doi: 10.1126/sciadv.abg5442

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DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics

Authors: Roberto Vázquez, Francisco J Caro-León, Alberto Nakal, Susana Ruiz, Carmen Doñoro, Luis García-Fernández, Blanca Vázquez-Lasa, Julio San Román, Jesús Sanz, Pedro García, María Rosa Aguilar

Journal: Carbohydr Polym

PubMed ID: 34561005

Doi: 10.1016/j.carbpol.2021.118605

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Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

Authors: Anastasiia Sukalskaia, Monique S Straub, Dawid Deneka, Marta Sawicka, Raimund Dutzler

Journal: Nat Commun

PubMed ID: 34385445

Doi: 10.1038/s41467-021-25106-4

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The Oxoglutarate Binding Site and Regulatory Mechanism Are Conserved in Ammonium Transporter Inhibitors GlnKs from

Authors: Marie-Caroline Müller, Tristan Wagner

Journal: Int J Mol Sci

PubMed ID: 34445335

Doi: 10.3390/ijms22168631

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Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

Authors: Pavlina Chuntova, Yafei Hou, Ryosuke Naka, Akane Yamamichi, Tiffany Chen, Yitzhar Goretsky, Ryusuke Hatae, Takahide Nejo, Gary Kohanbash, Abigail L Mende, Megan Montoya, Kira M Downey, David Diebold, Jayne Skinner, Hong-Erh Liang, Bjoern Schwer, Hideho Okada

Journal: Neuro Oncol

PubMed ID: 34347086

Doi: 10.1093/neuonc/noab182

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RGD-pectin microfiber patches for guiding muscle tissue regeneration

Authors: Chiara Emma Campiglio, Anna Carcano, Lorenza Draghi

Journal: J Biomed Mater Res A

PubMed ID: 34423891

Doi: 10.1002/jbm.a.37301

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Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma

Authors: Yue A Qi, Tapan K Maity, Constance M Cultraro, Vikram Misra, Xu Zhang, Catherine Ade, Shaojian Gao, David Milewski, Khoa D Nguyen, Mohammad H Ebrahimabadi, Ken-Ichi Hanada, Javed Khan, Cenk Sahinalp, James C Yang, Udayan Guha

Journal: Mol Cell Proteomics

PubMed ID: 34391887

Doi: 10.1016/j.mcpro.2021.100136

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ELMO1 signaling is a promoter of osteoclast function and bone loss

Authors: Sanja Arandjelovic, Justin S A Perry, Ming Zhou, Adam Ceroi, Igor Smirnov, Scott F Walk, Laura S Shankman, Isabelle Cambré, Suna Onengut-Gumuscu, Dirk Elewaut, Thomas P Conrads, Kodi S Ravichandran

Journal: Nat Commun

PubMed ID: 34404802

Doi: 10.1038/s41467-021-25239-6

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UbiD domain dynamics underpins aromatic decarboxylation

Authors: Stephen A Marshall, Karl A P Payne, Karl Fisher, Gabriel R Titchiner, Colin Levy, Sam Hay, David Leys

Journal: Nat Commun

PubMed ID: 34417452

Doi: 10.1038/s41467-021-25278-z

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BioParts-A Biological Parts Search Portal and Updates to the ICE Parts Registry Software Platform

Authors: Hector A Plahar, Thomas N Rich, Stephen D Lane, William C Morrell, Leanne Springthorpe, Oge Nnadi, Elena Aravina, Tiffany Dai, Michael J Fero, Nathan J Hillson, Christopher J Petzold

Journal: ACS Synth Biol

PubMed ID: 34449214

Doi: 10.1021/acssynbio.1c00263

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Bone developmental toxicity of organophosphorus flame retardants TDCIPP and TPhP in marine medaka Oryzias melastigma

Authors: Haizheng Hong, Yunchen Zhao, Lingming Huang, Daiyin Zhong, Dalin Shi

Journal: Ecotoxicol Environ Saf

PubMed ID: 34371453

Doi: 10.1016/j.ecoenv.2021.112605

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E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

Authors: Chirosree Bandyopadhyay, Leslayann Schecterson, Barry M Gumbiner

Journal: Tissue barriers

PubMed ID: 34402758

Doi: 10.1080/21688370.2021.1940741

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Analysis of the Manganese and MntR Regulon in Corynebacterium diphtheriae

Authors: Eric D Peng, Lindsey R Lyman, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 34370555

Doi: 10.1128/JB.00274-21

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Generation of hypoxia-sensing chimeric antigen receptor T cells

Authors: Paris Kosti, Karen I Larios-Martinez, John Maher, James N Arnold

Journal: STAR Protoc

PubMed ID: 34401788

Doi: 10.1016/j.xpro.2021.100723

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Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B

Authors: Zuzanna Pakosz, Ting-Yu Lin, Elizabeth Michalczyk, Soshichiro Nagano, Jonathan Gardiner Heddle

Journal: Antimicrob Agents Chemother

PubMed ID: 34339271

Doi: 10.1128/AAC.00267-21

Products & Services: Proteins, Expression, Isolation and Analysis

Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

Authors: Michelle P Aranha, Thomas A Penfound, Sanaz Salehi, Anne Botteaux, Pierre Smeesters, James B Dale, Jeremy C Smith

Journal: J Immunol

PubMed ID: 34341168

Doi: 10.4049/jimmunol.2100286

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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Authors: Lauren E Williamson, Kristen M Reeder, Kevin Bailey, Minh H Tran, Vicky Roy, Mallorie E Fouch, Nurgun Kose, Andrew Trivette, Rachel S Nargi, Emma S Winkler, Arthur S Kim, Christopher Gainza, Jessica Rodriguez, Erica Armstrong, Rachel E Sutton, Joseph Reidy, Robert H Carnahan, W Hayes McDonald, Clara T Schoeder, William B Klimstra, Edgar Davidson, Benjamin J Doranz, Galit Alter, Jens Meiler, Kevin L Schey, Justin G Julander, Michael S Diamond, James E Crowe

Journal: Cell

PubMed ID: 34416147

Doi: 10.1016/j.cell.2021.07.033

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Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage

Authors: Kamalakannan Vijayan, Ganesh Ram R Visweswaran, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L Brown, Alexander Watson, Meghan Zuck, Nicholas Dambrauskas, Andrew Raappana, Sara Carbonetti, Laurel Kelnhofer-Millevolte, Elizabeth K K Glennon, Rachel Postiglione, D Noah Sather, Alexis Kaushansky

Journal: Cell Rep

PubMed ID: 34348141

Doi: 10.1016/j.celrep.2021.109489

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iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

Authors: Danielle M Garshott, Heeseon An, Elayanambi Sundaramoorthy, Marilyn Leonard, Alison Vicary, J Wade Harper, Eric J Bennett

Journal: Cell Rep

PubMed ID: 34469731

Doi: 10.1016/j.celrep.2021.109642

Products & Services: Proteins, Expression, Isolation and Analysis

NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

Authors: Zikai Zhou, Guiqin He, Xiaoyun Zhang, Xin Lv, Xiaolin Zhang, An Liu, Shuting Xia, Hao Xie, Rui Dang, Lifang Han, Junxia Qi, Yanghong Meng, Shunying Yu, Wei Xie, Zhengping Jia

Journal: Cell Rep

PubMed ID: 34407403

Doi: 10.1016/j.celrep.2021.109515

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A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Authors: Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann

Journal: Nat Commun

PubMed ID: 34465781

Doi: 10.1038/s41467-021-25506-6

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Structural basis for Ca activation of the heteromeric PKD1L3/PKD2L1 channel

Authors: Qiang Su, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, Yigong Shi

Journal: Nat Commun

PubMed ID: 34381056

Doi: 10.1038/s41467-021-25216-z

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Systematic Genome-Wide Study and Expression Analysis of Gene Family: Sugar Transporter Family Contributes to Biotic and Abiotic Stimuli in Watermelon

Authors: Changqing Xuan, Guangpu Lan, Fengfei Si, Zhilong Zeng, Chunxia Wang, Vivek Yadav, Chunhua Wei, Xian Zhang

Journal: Int J Mol Sci

PubMed ID: 34445115

Doi: 10.3390/ijms22168407

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Extremely short bioavailability and fast pharmacodynamic effects of pMHC-based nanomedicines

Authors: Yang Yang, Kristofor K Ellestad, Santiswarup Singha, Muhammad Myn Uddin, Robert Clarke, Debajyoti Mondal, Nahir Garabatos, Patricia Solé, Cesar Fandos, Pau Serra, Pere Santamaria

Journal: J Control Release

PubMed ID: 34474072

Doi: 10.1016/j.jconrel.2021.08.043

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A resource of high-quality and versatile nanobodies for drug delivery

Authors: Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman-Duhovny, Carlos Camacho, Guillermo Calero, Baoli Hu, Yi Shi

Journal: iScience

PubMed ID: 34522857

Doi: 10.1016/j.isci.2021.103014

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Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Authors: Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana

Journal: iScience

PubMed ID: 34430803

Doi: 10.1016/j.isci.2021.103006

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Functional Characterization of the Nemertide α Family of Peptide Toxins

Authors: Erik Jacobsson, Steve Peigneur, Håkan S Andersson, Quentin Laborde, Malin Strand, Jan Tytgat, Ulf Göransson

Journal: J Nat Prod

PubMed ID: 34445875

Doi: 10.1021/acs.jnatprod.1c00104

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Fast and efficient generation of a full-length balancer chromosome by a single Cre/loxP recombination event

Authors: Cunxiang Ju, Mingkun Zhang, Min Guan, Song Li, Yuxi Zhang, Jing Zhao, Xiang Gao

Journal: Mamm Genome

PubMed ID: 34386878

Doi: 10.1007/s00335-021-09897-x

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Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

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Activation of gene expression by detergent-like protein domains

Authors: Bradley K Broyles, Andrew T Gutierrez, Theodore P Maris, Daniel A Coil, Thomas M Wagner, Xiao Wang, Daisuke Kihara, Caleb A Class, Alexandre M Erkine

Journal: iScience

PubMed ID: 34522860

Doi: 10.1016/j.isci.2021.103017

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Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Authors: Catarina F Almeida, Dylan G M Smith, Tan-Yun Cheng, Chris M Harpur, Elena Batleska, Catriona V Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J J Reddiex, Shihan Li, Sidonia B G Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P Uldrich, D Branch Moody, Spencer J Williams, Daniel G Pellicci, Dale I Godfrey

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34417291

Doi: 10.1073/pnas.2104420118

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SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Authors: Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Daniel Harari, Jeanne Chiaravalli, Björn Meyer, Yinon Rudich, Chunlin Li, Ira Marton, Orly Dym, Nadav Elad, Mark G Lewis, Hanne Andersen, Matthew Gagne, Robert A Seder, Daniel C Douek, Gideon Schreiber

Journal: Nat Microbiol

PubMed ID: 34400835

Doi: 10.1038/s41564-021-00954-4

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Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels

Authors: Dongfang Tang, Jiahui Xu, Yinping Li, Piao Zhao, Xiangjin Kong, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu

Journal: J Biol Chem

PubMed ID: 34391777

Doi: 10.1016/j.jbc.2021.101076

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An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

Authors: Jerod L Ptacin, Carolina E Caffaro, Lina Ma, Kristine M San Jose Gall, Hans R Aerni, Nicole V Acuff, Rob W Herman, Yelena Pavlova, Michael J Pena, David B Chen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Marcos E Milla

Journal: Nat Commun

PubMed ID: 34373459

Doi: 10.1038/s41467-021-24987-9

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Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice

Authors: Mingyuan Han, Tomoko Ishikawa, Claudia C Stroupe, Haley A Breckenridge, J Kelley Bentley, Marc B Hershenson

Journal: Mucosal Immunol

PubMed ID: 34354243

Doi: 10.1038/s41385-021-00436-0

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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

Authors: Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Charles Mosier, Christopher B Lietz, Gen Ito, William H Gerwick, Dennis W Wolan, Gregory Hook, Anthony J O'Donoghue, Vivian Hook

Journal: ACS Chem Biol

PubMed ID: 34416110

Doi: 10.1021/acschembio.1c00138

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Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Authors: Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui, Bin Wang

Journal: Stem Cell Res Ther

PubMed ID: 34419172

Doi: 10.1186/s13287-021-02537-w

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Proteome-Wide Profiling of Readers for DNA Modification

Authors: Lin Bai, Guojian Yang, Zhaoyu Qin, Jiacheng Lyu, Yunzhi Wang, Jinwen Feng, Mingwei Liu, Tongqing Gong, Xianju Li, Zhengyang Li, Jixi Li, Jun Qin, Wenjun Yang, Chen Ding

Journal: Adv Sci (Weinh)

PubMed ID: 34351703

Doi: 10.1002/advs.202101426

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Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes

Authors: Zhong-Qing Li, Yao Zhang, He Li, Ting-Ting Su, Cheng-Gong Liu, Zi-Chao Han, Ai-Ying Wang, Jian-Bo Zhu

Journal: Front Plant Sci

PubMed ID: 34490001

Doi: 10.3389/fpls.2021.696698

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Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene

Authors: Melanie L Bailey, David Tieu, Andrea Habsid, Amy Hin Yan Tong, Katherine Chan, Jason Moffat, Philip Hieter

Journal: Life Sci Alliance

PubMed ID: 34462321

Doi: 10.26508/lsa.202101083

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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Authors: Fei Liu, Amy C H Lee, Fang Guo, Andrew S Kondratowicz, Holly M Micolochick Steuer, Angela Miller, Lauren D Bailey, Xiaohe Wang, Shuai Chen, Steven G Kultgen, Andrea Cuconati, Andrew G Cole, Dimitar Gotchev, Bruce D Dorsey, Rene Rijnbrand, Angela M Lam, Michael J Sofia, Min Gao

Journal: J Virol

PubMed ID: 34191584

Doi: 10.1128/JVI.00574-21

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Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson's Disease

Authors: Min Chen, Li Peng, Ping Gong, Xiaoli Zheng, Tao Sun, Xiaoqiao Zhang, Jiangtao Huo

Journal: Biochem Res Int

PubMed ID: 34457363

Doi: 10.1155/2021/2319412

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COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity

Authors: Soo-Kyung Jeong, Yoon-Ki Heo, Jei-Hyun Jeong, Su-Jin Ham, Jung-Sun Yum, Byung-Cheol Ahn, Chang-Seon Song, Eun-Young Chun

Journal: Vaccines (Basel)

PubMed ID: 34579194

Doi: 10.3390/vaccines9090957

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MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A

Authors: Maayan Hemed-Shaked, Mary K Cowman, Jin Ryoun Kim, Xiayun Huang, Edward Chau, Haim Ovadia, Keren-Or Amar, Lora Eshkar-Sebban, Michal Melamed, Libat Bar Lev, Eli Kedar, Jordi Armengol, Jorge Alemany, Shaul Beyth, Eli Okon, Darja Kanduc, Sharona Elgavish, Shulamit B Wallach-Dayan, Shmuel Jaffe Cohen, David Naor

Journal: J Autoimmun

PubMed ID: 34390919

Doi: 10.1016/j.jaut.2021.102713

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Influence of Electrolyte Concentration on Single-Molecule Sensing of Perfluorocarboxylic Acids

Authors: Xinyun Yao, Ning-Ning Song, Jia Wang, Xian Zhao, Meng-Yuan Cheng, Jiaqi Zuo, Kaipei Qiu

Journal: Front Chem

PubMed ID: 34414165

Doi: 10.3389/fchem.2021.732378

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Genome-wide identification of CK gene family suggests functional expression pattern against Cd stress in Gossypium hirsutum L

Authors: Jing Wang, Yuexin Zhang, Nan Xu, Hong Zhang, Yapeng Fan, Cun Rui, Mingge Han, Waqar Afzal Malik, Qinqin Wang, Liangqing Sun, Xiugui Chen, Xuke Lu, Delong Wang, Lanjie Zhao, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Wuwei Ye

Journal: Int J Biol Macromol

PubMed ID: 34364943

Doi: 10.1016/j.ijbiomac.2021.07.190

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Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients

Authors: Victoria G Hall, Victor H Ferreira, Matthew Ierullo, Terrance Ku, Tina Marinelli, Beata Majchrzak-Kita, Anila Yousuf, Vathany Kulasingam, Atul Humar, Deepali Kumar

Journal: Am J Transplant

PubMed ID: 34347934

Doi: 10.1111/ajt.16766

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mRNA Vaccines Enhance Neutralizing Immunity against SARS-CoV-2 Variants in Convalescent and ChAdOx1-Primed Subjects

Authors: Dorit Fabricius, Carolin Ludwig, Judith Scholz, Immanuel Rode, Chrysanthi Tsamadou, Eva-Maria Jacobsen, Martina Winkelmann, Aline Grempels, Ramin Lotfi, Aleš Janda, Sixten Körper, Guido Adler, Klaus-Michael Debatin, Hubert Schrezenmeier, Bernd Jahrsdörfer

Journal: Vaccines (Basel)

PubMed ID: 34452043

Doi: 10.3390/vaccines9080918

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HSP70 inhibition suppressed glioma cell viability during hypoxia/reoxygenation by inhibiting the ERK1/2 and PI3K/AKT signaling pathways

Authors: Haiyan Liu, Zhi Li, Qingshu Li, Chao Jia, Nan Zhang, Yan Qu, Dan Hu

Journal: J Bioenerg Biomembr

PubMed ID: 34363569

Doi: 10.1007/s10863-021-09904-5

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Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction

Authors: Di Guo, Yi-Jie Zhang, Su Zhang, Jian Li, Chao Guo, Yu-Feng Pan, Ning Zhang, Chen-Xi Liu, Ya-Long Jia, Chen-Yu Li, Jun-Yu Ma, Dick R Nässel, Cong-Fen Gao, Shun-Fan Wu

Journal: PLoS Genet

PubMed ID: 34398892

Doi: 10.1371/journal.pgen.1009724

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Anti-contactin-1 Antibodies Affect Surface Expression and Sodium Currents in Dorsal Root Ganglia

Authors: Julia Grüner, Helena Stengel, Christian Werner, Luise Appeltshauser, Claudia Sommer, Carmen Villmann, Kathrin Doppler

Journal: Neurol Neuroimmunol Neuroinflamm

PubMed ID: 34429341

Doi: 10.1212/NXI.0000000000001056

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-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Authors: Cheleka A M Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D Reid, Nicole Bilek, Morten Ruhwald, Jason R Andrews, Mark Hatherill, Francesca Little, Thomas J Scriba, Elisa Nemes

Journal: Front Immunol

PubMed ID: 34526988

Doi: 10.3389/fimmu.2021.712480

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Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection

Authors: Pembe Derin Oygar, Yasemin Ozsurekci, Sibel Lacinel Gurlevik, Kubra Aykac, Musa Gurel Kukul, Burcu Ceylan Cura Yayla, Sare Ilbay, Jale Karakaya, Ozlem Teksam, Ali Bulent Cengiz, Mehmet Ceyhan

Journal: Pediatr Infect Dis J

PubMed ID: 34250968

Doi: 10.1097/INF.0000000000003199

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Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior

Authors: Ravi Das, Shatabdi Bhattacharjee, Jamin M Letcher, Jenna M Harris, Sumit Nanda, Istvan Foldi, Erin N Lottes, Hansley M Bobo, Benjamin D Grantier, József Mihály, Giorgio A Ascoli, Daniel N Cox

Journal: Development

PubMed ID: 34322714

Doi: 10.1242/dev.187609

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Synthesis of precision antibody conjugates using proximity-induced chemistry

Authors: Yu J Cao, Chenfei Yu, Kuan-Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao

Journal: Theranostics

PubMed ID: 34522229

Doi: 10.7150/thno.62444

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Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation

Authors: Caixia Liu, Benlong Cai, Dan Li, Yuan Yao

Journal: Innate Immun

PubMed ID: 34428935

Doi: 10.1177/17534259211035426

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Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease

Authors: Stéphanie Andrade, Joana Angélica Loureiro, Maria do Carmo Pereira

Journal: Arch Biochem Biophys

PubMed ID: 34461085

Doi: 10.1016/j.abb.2021.109022

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