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Dynamic Changes in the Levels of Amyloid-β Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease

Authors: Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo

Journal: Front Mol Neurosci

PubMed ID: 34512259

Doi: 10.3389/fnmol.2021.723317

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Compound heterozygosis in AADC deficiency: A complex phenotype dissected through comparison among heterodimeric and homodimeric AADC proteins

Authors: Carmen Longo, Riccardo Montioli, Giovanni Bisello, Luana Palazzi, Mario Mastrangelo, Heiko Brennenstuhl, Patrizia Polverino de Laureto, Thomas Opladen, Vincenzo Leuzzi, Mariarita Bertoldi

Journal: Mol Genet Metab

PubMed ID: 34479793

Doi: 10.1016/j.ymgme.2021.08.011

Products & Services: Monoclonal Antibody Services

Generation and characterization of a humanized anti-IL-17A rabbit monoclonal antibody

Authors: Wei Chen, Yong Kong, Wang Li, Yi Zhou, Meijuan Wu, Tao Chen, Yiliang Wu, Huaiyao Qiao, Zhihua Qiu, Jiwan Qiu

Journal: Protein Expr Purif

PubMed ID: 34363980

Doi: 10.1016/j.pep.2021.105950

Products & Services: Mammalian Expression

Knockdown of miR-125b-5p inhibits the proliferation and invasion of gastric carcinoma cells by targeting RYBP

Authors: Fu-E Jin, Bo Xie, Hong-Zhen Xian, Ji-Hai Wang

Journal: Kaohsiung J Med Sci

PubMed ID: 34337862

Doi: 10.1002/kjm2.12425

Products & Services: GenParts™ DNA Fragments

Structure, Antigenic Properties, and Highly Efficient Assembly of PCV4 Capsid Protein

Authors: Dongliang Wang, Jinhui Mai, Bo Lei, Yingjie Zhang, Yi Yang, Naidong Wang

Journal: Front Vet Sci

PubMed ID: 34504886

Doi: 10.3389/fvets.2021.695466

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Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Authors: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi

Journal: J Exp Clin Cancer Res

PubMed ID: 34364401

Doi: 10.1186/s13046-021-02049-8

Products & Services: GenCrispr Cas9 Genome Editing

Industry updates from the field of stem cell research and regenerative medicine in June 2021

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 34387128

Doi: 10.2217/rme-2021-0097

Products & Services: GenCrispr Cas9 Genome Editing

P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway

Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao

Journal: Cell Cycle

PubMed ID: 34382920

Doi: 10.1080/15384101.2021.1963910

Products & Services: DNA Sequencing

β-Amyloid fibrils catalyze neurotransmitter degradation

Authors: Elad Arad, Avigail Baruch Leshem, Hanna Rapaport, Raz Jelinek

Journal: Chem Catalysis

Doi: 10.1016/j.checat.2021.07.005

Products & Services: Peptide Synthesis

Identification of a peptide binding to cancer antigen Kita‐kyushu lung cancer antigen 1 from a phage‐display library

Authors: Xiaoxiao Yu, Jiayao Yan,Xiaotong Chen,Jia Wei,Lixia Yu,Fangcen Liu,Lin Li,Baorui Liu

Journal: Cancer Science

PubMed ID: 34387029

Doi: 10.1111/cas.15109

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Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

Authors: Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu, Yang, Kejing Ren,Meiling Lu,and Yibei Xiao

Journal: Nucleic Acids Research

PubMed ID: 34428286

Doi: 10.1093/nar/gkab725

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Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Authors: Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P Seward, Ricardo Borges, José David Machado

Journal: Cell Rep

PubMed ID: 34433018

Doi: 10.1016/j.celrep.2021.109609

Products & Services: PCR and Cloning

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Authors: Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin

Journal: Blood

PubMed ID: 34359076

Doi: 10.1182/blood.2021012629

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How to Sequence Therapies in Waldenström Macroglobulinemia

Authors: Shayna Sarosiek, Steven P Treon, Jorge J Castillo

Journal: Curr Treat Options Oncol

PubMed ID: 34426943

Doi: 10.1007/s11864-021-00890-9

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Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates

Authors: Yongzhe Zhang, Fei Liu, Yan Zhao, Fan Yang, Jie Bai, Xitong Jia, Wanlapa Roobsoong, Jetsumon Sattabongkot, Liwang Cui, Yaming Cao, Enjie Luo, Meilian Wang

Journal: Parasit Vectors

PubMed ID: 34399829

Doi: 10.1186/s13071-021-04909-w

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A novel pine wood nematode effector, BxSCD1, suppresses plant immunity and interacts with an ethylene-forming enzyme in pine

Authors: Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui, Yan Zhang, Xiao-Lei Ding, Jian-Ren Ye

Journal: Mol Plant Pathol

PubMed ID: 34396673

Doi: 10.1111/mpp.13121

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleomodulin Ank13 Exploits the RaDAR Nuclear Import Pathway To Modulate Host Cell Transcription

Authors: Haley E Adcox, Amanda L Hatke, Shelby E Andersen, Sarika Gupta, Nathan B Otto, Mary M Weber, Richard T Marconi, Jason A Carlyon

Journal: MBio

PubMed ID: 34340535

Doi: 10.1128/mBio.01816-21

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Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Authors: Léa Chuzel, Samantha L Fossa, Madison L Boisvert, Samanta Cajic, René Hennig, Mehul B Ganatra, Udo Reichl, Erdmann Rapp, Christopher H Taron

Journal: Microb Cell Fact

PubMed ID: 34419057

Doi: 10.1186/s12934-021-01652-w

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Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71)

Authors: Salima Lalani, Malihe Masomian, Chit Laa Poh

Journal: Int J Mol Sci

PubMed ID: 34445463

Doi: 10.3390/ijms22168757

Products & Services: Plasmid DNA Preparation

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Authors: Kerry L Hilligan, Sivaranjani Namasivayam, Chad S Clancy, Danielle O'Mard, Sandra D Oland, Shelly J Robertson, Paul J Baker, Ehydel Castro, Nicole L Garza, Bernard A P Lafont, Reed Johnson, Franca Ronchese, Katrin D Mayer-Barber, Sonja M Best, Alan Sher

Journal: biorxiv

PubMed ID: 34494021

Doi: 10.1101/2021.08.30.458273

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The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation

Authors: Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek, Natalia O Tjokro, Santiago Partida-Sanchez, Lauren O Bakaletz, Steven D Goodman

Journal: J Clin Invest

PubMed ID: 34396989

Doi: 10.1172/JCI140527

Products & Services: Bacterial Expression

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Authors: Aleksandar Antanasijevic, Leigh M Sewall, Christopher A Cottrell, Diane G Carnathan, Luis E Jimenez, Julia T Ngo, Jennifer B Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D Allen, Jeffrey Copps, Hailee R Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T Berndsen, David Baker, Neil P King, Rogier W Sanders, John P Moore, Shane Crotty, Max Crispin, David C Montefiori, Dennis R Burton, William R Schief, Guido Silvestri, Andrew B Ward

Journal: Nat Commun

PubMed ID: 34376662

Doi: 10.1038/s41467-021-25087-4

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Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast

Authors: Imane M Rezig, Wandiahyel G Yaduma, Gwyn W Gould, Christopher J McInerny

Journal: Cell Cycle

PubMed ID: 34382912

Doi: 10.1080/15384101.2021.1962637

Products & Services: DNA Sequencing

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Authors: Erika Casari, Elisa Gobbini, Marco Gnugnoli, Marco Mangiagalli, Michela Clerici, Maria Pia Longhese

Journal: Nat Commun

PubMed ID: 34362907

Doi: 10.1038/s41467-021-25090-9

Products & Services: Bacterial Expression

Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Authors: Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V Pai, Ramakrishnan Melarkode Subbaraman

Journal: Sci Rep

PubMed ID: 34462514

Doi: 10.1038/s41598-021-96916-1

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Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Authors: Ioannis P Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis, Meletios A Dimopoulos

Journal: BMC Med

PubMed ID: 34420521

Doi: 10.1186/s12916-021-02090-6

Rv0927c Inhibits NF-κB Pathway by Downregulating the Phosphorylation Level of IκBα and Enhances Mycobacterial Survival

Authors: Aihong Xia, Xin Li, Juanjuan Quan, Xiang Chen, Zhengzhong Xu, Xinan Jiao

Journal: Front Immunol

PubMed ID: 34531869

Doi: 10.3389/fimmu.2021.721370

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Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Authors: Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Laia Fontdevila, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin

Journal: Int J Mol Sci

PubMed ID: 34445555

Doi: 10.3390/ijms22168853

Products & Services: Proteins, Expression, Isolation and Analysis

Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer

Authors: Hester A Doyle, Renelle J Gee, Tyler D Masters, Christian R Gee, Carmen J Booth, Elizabeth Peterson-Roth, Raymond A Koski, Stuart C Helfand, Lauren Price, Deborah Bascombe, Dorothy Jackson, Rita Ho, Gerald R Post, Mark J Mamula

Journal: Transl Oncol

PubMed ID: 34419682

Doi: 10.1016/j.tranon.2021.101205

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses

Authors: Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato

Journal: Viruses

PubMed ID: 34578314

Doi: 10.3390/v13091733

Products & Services: Gene Synthesis

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Authors: Zhaoyong Zhang, Eric Zeng, Lu Zhang, Weiming Wang, Yingkang Jin, Jiye Sun, Shuxiang Huang, Wenguang Yin, Jun Dai, Zhen Zhuang, Zhao Chen, Jing Sun, Airu Zhu, Fang Li, Weitao Cao, Xiaobo Li, Yongxia Shi, Mian Gan, Shengnan Zhang, Peilan Wei, Jicheng Huang, Nanshan Zhong, Guocai Zhong, Jingxian Zhao, Yanqun Wang, Weihui Shao, Jincun Zhao

Journal: Cell Discov

PubMed ID: 34385423

Doi: 10.1038/s41421-021-00302-0

Products & Services: Mutant Libraries

Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43 in Glioblastoma Stem Cells

Authors: Sara G Pelaz, Claudia Ollauri-Ibáñez, Concepción Lillo, Arantxa Tabernero

Journal: Cancers (Basel)

PubMed ID: 34503072

Doi: 10.3390/cancers13174262

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Genome-Wide Identification and Expression Analysis of MYB Transcription Factor Superfamily in

Authors: Tingting Zhang, Zheng Cui, Yuxin Li, Yuqian Kang, Xiqiang Song, Jian Wang, Yang Zhou

Journal: Front Genet

PubMed ID: 34512725

Doi: 10.3389/fgene.2021.714696

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SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy

Authors: Yajing Zhang, Xiaohong Yu, Qiuping Liu, Haiping Gong, An-An Chen, Hongjun Zheng, Shi Zhong, Yi Li

Journal: Mol Cancer Ther

PubMed ID: 34465596

Doi: 10.1158/1535-7163.MCT-21-0203

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Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity

Authors: Ramona Dolscheid-Pommerich, Eva Bartok, Marcel Renn, Beate M Kümmerer, Bianca Schulte, Ricarda M Schmithausen, Birgit Stoffel-Wagner, Hendrik Streeck, Sandra Saschenbrecker, Katja Steinhagen, Gunther Hartmann

Journal: J Med Virol

PubMed ID: 34415572

Doi: 10.1002/jmv.27287

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Authors: Olusegun O Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A Rouf Banday, Thomas R O'Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson

Journal: Front Immunol

PubMed ID: 34497603

Doi: 10.3389/fimmu.2021.692263

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia

Authors: Wurihan Wurihan, Yi Zou, Alec M Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, Huizhou Fan

Journal: mSystems

PubMed ID: 34342542

Doi: 10.1128/mSystems.00738-21

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Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

Authors: Thomas Güttler, Metin Aksu, Antje Dickmanns, Kim M Stegmann, Kathrin Gregor, Renate Rees, Waltraud Taxer, Oleh Rymarenko, Jürgen Schünemann, Christian Dienemann, Philip Gunkel, Bianka Mussil, Jens Krull, Ulrike Teichmann, Uwe Groß, Volker C Cordes, Matthias Dobbelstein, Dirk Görlich

Journal: EMBO J

PubMed ID: 34302370

Doi: 10.15252/embj.2021107985

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α-Synuclein kinetically regulates the nascent fusion pore dynamics

Authors: Rohith K Nellikka, Bhavya R Bhaskar, Kinjal Sanghrajka, Swapnali S Patil, Debasis Das

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34413185

Doi: 10.1073/pnas.2021742118

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BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments

Authors: Hunter W Kuhn, Amanda G Lasseter, Philip P Adams, Carlos Flores Avile, Brandee L Stone, Darrin R Akins, Travis J Jewett, Mollie W Jewett

Journal: PLoS Pathog

PubMed ID: 34415955

Doi: 10.1371/journal.ppat.1009869

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cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Authors: Takahiro Ishizaki, Masahito Asada, Hassan Hakimi, Nattawat Chaiyawong, Yuto Kegawa, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34390881

Doi: 10.1016/j.parint.2021.102435

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Genome-wide Analysis of Basic Helix-Loop-Helix Family Genes and Expression Analysis in Response to Drought and Salt Stresses in Sieb et Zucc

Authors: Longjie Ni, Zhiquan Wang, Zekai Fu, Dina Liu, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Int J Mol Sci

PubMed ID: 34445454

Doi: 10.3390/ijms22168748

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Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

Authors: V Dumrongprechachan, R B Salisbury, G Soto, M Kumar, M L MacDonald, Y Kozorovitskiy

Journal: Nat Commun

PubMed ID: 34381044

Doi: 10.1038/s41467-021-25144-y

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Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Authors: Qingzhuoma Yang, Shengtao Guo, Qi Lu, Yong Tao, Decong Zheng, Qinmao Zhou, Jun Liu

Journal: Biosci Rep

PubMed ID: 34338280

Doi: 10.1042/BSR20211135

Products & Services: Proteins, Expression, Isolation and Analysis

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha El Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Journal: EBioMedicine

PubMed ID: 34388518

Doi: 10.1016/j.ebiom.2021.103521

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Genome-wide characterization and expression profiling of the Phospholipase C (PLC) gene family in three orchids of economic importance

Authors: Madhvi Kanchan, Thakku R Ramkumar, Jaspreet K Sembi

Journal: J Genet Eng Biotechnol

PubMed ID: 34420115

Doi: 10.1186/s43141-021-00217-z

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The nucleotide addition cycle of the SARS-CoV-2 polymerase

Authors: Subhas Chandra Bera, Mona Seifert, Robert N Kirchdoerfer, Pauline van Nies, Yibulayin Wubulikasimu, Salina Quack, Flávia S Papini, Jamie J Arnold, Bruno Canard, Craig E Cameron, Martin Depken, David Dulin

Journal: Cell Rep

PubMed ID: 34433083

Doi: 10.1016/j.celrep.2021.109650

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Spore-Trained Dendritic Cells Enhance the Generation of Memory T Cells via ICAM1

Authors: Jian Lin, Lulu Huang, Yuchen Li, Penghao Zhang, Qinghua Yu, Qian Yang

Journal: Cells

PubMed ID: 34571913

Doi: 10.3390/cells10092267

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Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery

Authors: Chengqian Feng, Jingrong Shi, Qinghong Fan, Yaping Wang, Huang Huang, Fengjuan Chen, Guofang Tang, Youxia Li, Pingchao Li, Jiaojiao Li, Jianping Cui, Liliangzi Guo, Sisi Chen, Mengling Jiang, Liqiang Feng, Ling Chen, Chunliang Lei, Changwen Ke, Xilong Deng, Fengyu Hu, Xiaoping Tang, Feng Li

Journal: Nat Commun

PubMed ID: 34404803

Doi: 10.1038/s41467-021-25312-0

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A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses

Authors: Cansu Cimen Bozkus, Ana Belen Blazquez, Tomohiro Enokida, Nina Bhardwaj

Journal: STAR Protoc

PubMed ID: 34458873

Doi: 10.1016/j.xpro.2021.100758

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N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Authors: Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick C J Dobson

Journal: J Biol Chem

PubMed ID: 34437902

Doi: 10.1016/j.jbc.2021.101113

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PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

Authors: Hui Li, Defang Meng, Jieting Jia, Hua Wei

Journal: Lipids Health Dis

PubMed ID: 34461924

Doi: 10.1186/s12944-021-01515-8

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Vestibular and Auditory Hair Cell Regeneration Following Targeted Ablation of Hair Cells With Diphtheria Toxin in Zebrafish

Authors: Erin Jimenez, Claire C Slevin, Luis Colón-Cruz, Shawn M Burgess

Journal: Front Cell Neurosci

PubMed ID: 34489643

Doi: 10.3389/fncel.2021.721950

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Genome-Wide Identification, Expression and Functional Analysis Reveal the Involvement of FCS-Like Zinc Finger Gene Family in Submergence Response in Rice

Authors: Yamei Ma, Junliang Zhao, Hua Fu, Tifeng Yang, Jingfang Dong, Wu Yang, Luo Chen, Lian Zhou, Jian Wang, Bin Liu, Shaohong Zhang, David Edwards

Journal: Rice (N Y)

PubMed ID: 34417910

Doi: 10.1186/s12284-021-00519-3

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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4 T-cells

Authors: Vijaya L Simhadri, Louis Hopkins, Joseph R McGill, Brian R Duke, Swati Mukherjee, Kate Zhang, Zuben E Sauna

Journal: Nat Commun

PubMed ID: 34429421

Doi: 10.1038/s41467-021-25414-9

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Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish

Authors: Caitlin Hyland, Michael Mfarej, Giorgos Hiotis, Sabrina Lancaster, Noelle Novak, M Kathryn Iovine, Matthias M Falk

Journal: Mol Biol Cell

PubMed ID: 34379446

Doi: 10.1091/mbc.E20-12-0797

Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM

Authors: Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong Cheung, Jason S Lewis

Journal: J Nucl Med

PubMed ID: 34353869

Doi: 10.2967/jnumed.121.262383

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The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol

Authors: Haruka Sudo, Akira Kubo

Journal: Int J Mol Sci

PubMed ID: 34502304

Doi: 10.3390/ijms22179397

Products & Services: Mammalian Expression

Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow's Milk Allergy

Authors: Yaqiong Cui, Yang Yu, Shuxiang Lin, Li Xu, Liuxu Li, Chunquan Cai, Huiqiang Li

Journal: Int Arch Allergy Immunol

PubMed ID: 34515139

Doi: 10.1159/000517998

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Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy

Authors: Xiaobei Cheng, Pei Yu, Xiang Zhou, Jiale Zhu, Yubao Han, Chao Zhang, Lingyi Kong

Journal: Acta Pharm Sin B

PubMed ID: 35256955

Doi: 10.1016/j.apsb.2021.08.018

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Molecular Cloning and Expression Profile of Class Genes Related to Sepal Development in

Authors: Zhuoxing Liu, Dasheng Zhang, Weiwei Zhang, Lei Xiong, Qingqing Liu, Fengluan Liu, Hanchun Li, Xiangjie An, Lijie Cui, Daike Tian

Journal: Plants (Basel)

PubMed ID: 34451674

Doi: 10.3390/plants10081629

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Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins

Authors: Jongjin Park, Jiyoung Yoon, Daekee Kwon, Mi-Jung Han, Sunmee Choi, Slki Park, Junghyuk Lee, Kiwook Lee, Jaehwan Lee, Seunghee Lee, Kyung-Sun Kang, Sunghwa Choe

Journal: Sci Rep

PubMed ID: 34376729

Doi: 10.1038/s41598-021-95406-8

Products & Services: Mammalian Expression

Evidence that class I glutamine amidotransferase, GAT1_21, acts as a glutaminase in roots of Arabidopsis thaliana

Authors: Shrikaar Kambhampati, Aga Pajak, Frédéric Marsolais

Journal: Plant Sci

PubMed ID: 34620437

Doi: 10.1016/j.plantsci.2021.111033

Products & Services: Proteins, Expression, Isolation and Analysis

Der p 38 Is a Bidirectional Regulator of Eosinophils and Neutrophils in Allergy

Authors: Min Hwa Hong, Ayesha Kashif, Geunyeong Kim, Beom Seok Park, Na Rae Lee, Eun Ju Yang, Ji Young Mun, Hyosun Choi, Sang-Hoon Kim, Hyun Jik Kim, Soo Jin Lee, Ji-Sook Lee, Yujin Hong, In Sik Kim

Journal: J Immunol

PubMed ID: 34462314

Doi: 10.4049/jimmunol.2001144

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Quantitative SARS-CoV-2 Spike Antibody Response in COVID-19 Patients Using Three Fully Automated Immunoassays and a Surrogate Virus Neutralization Test

Authors: Yoonjoo Kim, Ji Hyun Lee, Geon Young Ko, Ji Hyeong Ryu, Joo Hee Jang, Hyunjoo Bae, Seung-Hyo Yoo, Ae-Ran Choi, Jin Jung, Jongmin Lee, Eun-Jee Oh

Journal: Diagnostics (Basel)

PubMed ID: 34441430

Doi: 10.3390/diagnostics11081496

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Host Recognition Mechanism of the K1 Capsule-Specific Phage of : Capsular Polysaccharide as the First Receptor and Lipopolysaccharide as the Secondary Receptor

Authors: Qianwen Gong, Xuhang Wang, Haosheng Huang, Yu Sun, Xinjie Qian, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang

Journal: J Virol

PubMed ID: 34191582

Doi: 10.1128/JVI.00920-21

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways

Authors: Lihe Sun, Juan Ouyang, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng, Shuizhu Wu

Journal: Bioact Mater

PubMed ID: 34901531

Doi: 10.1016/j.bioactmat.2021.08.010

Products & Services: Proteins, Expression, Isolation and Analysis

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Authors: Qingqing Chai, Sunan Li, Morgan K Collins, Rongrong Li, Iqbal Ahmad, Silas F Johnson, Dylan A Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F Hultquist, B Matija Peterlin, Yong-Hui Zheng

Journal: Cell Rep

PubMed ID: 34380030

Doi: 10.1016/j.celrep.2021.109514

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Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

Authors: Olivia Swanson, Brianna Rhodes, Avivah Wang, Shi-Mao Xia, Robert Parks, Haiyan Chen, Aja Sanzone, Melissa Cooper, Mark K Louder, Bob C Lin, Nicole A Doria-Rose, Mattia Bonsignori, Kevin O Saunders, Kevin Wiehe, Barton F Haynes, Mihai L Azoitei

Journal: Cell Rep

PubMed ID: 34407396

Doi: 10.1016/j.celrep.2021.109561

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TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways

Authors: Alex Jose Pulikkottil, Shiva Bamezai, Tobias Ammer, Fabian Mohr, Kristin Feder, Naidu M Vegi, Tamoghna Mandal, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Amit Sinha, Christian Buske, Vijay P S Rawat

Journal: Leukemia

PubMed ID: 34462525

Doi: 10.1038/s41375-021-01390-3

Products & Services: Stable Cell Lines

Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients

Authors: Victoria G Hall, Victor H Ferreira, Terrance Ku, Matthew Ierullo, Beata Majchrzak-Kita, Cecilia Chaparro, Nazia Selzner, Jeffrey Schiff, Michael McDonald, George Tomlinson, Vathany Kulasingam, Deepali Kumar, Atul Humar

Journal: N Engl J Med

PubMed ID: 34379917

Doi: 10.1056/NEJMc2111462

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Context-Specific Function of the Engineered Peptide Domain of PHPB

Authors: R Alexander Martino, Edwin C Fluck, Jacqueline Murphy, Qiang Wang, Henry Hoff, Ruth A Pumroy, Claudia Y Lee, Joshua J Sims, Soumitra Roy, Vera Y Moiseenkova-Bell, James M Wilson

Journal: J Virol

PubMed ID: 34346767

Doi: 10.1128/JVI.01164-21

Products & Services: Recombinant Antibody Expression

Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src

Authors: Xiao-Li Jiang, Bo Deng, Sui-Hui Deng, Min Cai, Wen-Jun Ding, Zhang-Bin Tan, Rui-Xue Chen, You-Cai Xu, Hong-Lin Xu, Shuang-Wei Zhang, Shi-Qing Zhang, Bin Liu, Jing-Zhi Zhang

Journal: Phytomedicine

PubMed ID: 34538671

Doi: 10.1016/j.phymed.2021.153705

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2

Authors: Yuqiang Zhang, Yan Xu, Yunpeng Dai, Zhe Li, Jiaxing Wang, Zhi Ye, Yanxin Ren, Hua Wang, Wan-Xiang Li, Jinfeng Lu, Shou-Wei Ding, Yang Li

Journal: PLoS Pathog

PubMed ID: 34343211

Doi: 10.1371/journal.ppat.1009790

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Multigenerational selection towards longevity changes the protective role of vitamin C against graphene oxide-induced oxidative stress in house crickets

Authors: Barbara Flasz, Marta Dziewięcka, Andrzej Kędziorski, Monika Tarnawska, Jan Augustyniak, Maria Augustyniak

Journal: Environ Pollut

PubMed ID: 34416498

Doi: 10.1016/j.envpol.2021.117996

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a Minimal α-Carboxysome-Derived Shell and Its Utility in Enzyme Stabilization

Authors: Yong Quan Tan, Samson Ali, Bo Xue, Wei Zhe Teo, Lay Hiang Ling, Maybelle Kho Go, Hong Lv, Robert C Robinson, Akihiro Narita, Wen Shan Yew

Journal: Biomacromolecules

PubMed ID: 34384019

Doi: 10.1021/acs.biomac.1c00533

Products & Services: Proteins, Expression, Isolation and Analysis

Combined 4-1BB and ICOS co-stimulation improves anti-tumor efficacy and persistence of dual anti-CD19/CD20 chimeric antigen receptor T cells

Authors: Ying Wang, Kailun Zhong, Jun Ke, Xi Chen, Yi Chen, Wangyun Shu, Chunhuan Chen, Shan Hu, Xiaoke Sun, Haibin Huang, Chong Luo, Lifang Liu, Jiaming Yang, Yongke Zhang, Huijun Zhi

Journal: Cytotherapy

PubMed ID: 33863641

Doi: 10.1016/j.jcyt.2021.02.117

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Glutamate-Putrescine Ligase Activity in : A New Function for Gene

Authors: Verónica Rodríguez-Herrero, Arnau Peris, Mónica Camacho, Vanesa Bautista, Julia Esclapez, María-José Bonete

Journal: Biomolecules

PubMed ID: 34439822

Doi: 10.3390/biom11081156

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Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

Authors: Erica M Briggs, Paolo Mita, Xiaoji Sun, Susan Ha, Nikita Vasilyev, Zev R Leopold, Evgeny Nudler, Jef D Boeke, Susan K Logan

Journal: Mob DNA

PubMed ID: 34425899

Doi: 10.1186/s13100-021-00249-9

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Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease

Authors: Peter Simons, Yan Guo, Virginie Bondu, Susan L Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A Lawrence, Tione Buranda

Journal: Viruses

PubMed ID: 34452463

Doi: 10.3390/v13081597

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Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

Authors: Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-Mao Xia, Mattia Bonsignori, David Montefiori, Qifeng Han, Sravani Venkatayogi, Tyler Evangelous, Yunfei Wang, Wes Rountree, Ying Tam, Christopher Barbosa, S Munir Alam, Wilton B Williams, Norbert Pardi, Drew Weissman, Barton F Haynes

Journal: biorxiv

PubMed ID: 34401876

Doi: 10.1101/2021.08.09.455714

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A truncated glycoprotein G vaccine formulated with Advax-CpG adjuvant provides protection of mice against genital herpes simplex virus 2 infection

Authors: Staffan Görander, Yoshikazu Honda-Okubo, Malin Bäckström, Jeremy Baldwin, Tomas Bergström, Nikolai Petrovsky, Jan-Åke Liljeqvist

Journal: Vaccine

PubMed ID: 34456075

Doi: 10.1016/j.vaccine.2021.08.050

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DNA-guided photoactivatable probe-based chemical proteomics reveals the reader protein of mRNA methylation

Authors: Yepei Huang, Xue Bai, Zhenchang Guo, Hanyang Dong, Yun Fu, Hui Zhang, Guijin Zhai, Shanshan Tian, Ye Wang, Kai Zhang

Journal: iScience

PubMed ID: 34553132

Doi: 10.1016/j.isci.2021.103046

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Interaction of Antimicrobial Peptide Ponericin W1, Thanatin, and Mastatopara-S with Genomic DNA

Authors: Hongyan Zhang, Sha Liu, Xindan Li, Wenjun Wang, Lili Deng, Kaifang Zeng

Journal: Foods

PubMed ID: 34441696

Doi: 10.3390/foods10081919

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Optimization of antigen-specific CD8 T cell activation conditions for infectious diseases including COVID-19

Authors: Chanchan Xiao, Congling Qiu, Jieping Deng, Jiezhou Ye, Lijuan Gao, Jun Su, Oscar Junhong Luo, Pengcheng Wang, Guobing Chen

Journal: STAR Protoc

PubMed ID: 34414379

Doi: 10.1016/j.xpro.2021.100789

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Dual concentration-dependent effect of ascorbic acid on PAP(248-286) amyloid formation and SEVI-mediated HIV infection

Authors: Satabdee Mohapatra, Guru Krishna Kumar Viswanathan, Lukas Wettstein, Elad Arad, Ashim Paul, Vijay Kumar, Raz Jelinek, Jan Münch, Daniel Segal

Journal: RSC Chem Biol

PubMed ID: 34704058

Doi: 10.1039/d1cb00084e

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Targeted genetic screening in bacteria with a Cas12k-guided transposase

Authors: Weizhong Chen, Ze-Hui Ren, Na Tang, Guoshi Chai, Hongyuan Zhang, Yifei Zhang, Jiacheng Ma, Zhaowei Wu, Xia Shen, Xingxu Huang, Guan-Zheng Luo, Quanjiang Ji

Journal: Cell Rep

PubMed ID: 34469724

Doi: 10.1016/j.celrep.2021.109635

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Vaccination against the Protozoan Parasite Primes the Activation of Toll-like Receptors in Turkeys and Chickens Determined by a Set of Newly Developed Multiplex RT-qPCRs

Authors: Taniya Mitra, Beatrice Bramberger, Ivana Bilic, Michael Hess, Dieter Liebhart

Journal: Vaccines (Basel)

PubMed ID: 34579197

Doi: 10.3390/vaccines9090960

Products & Services: ORF cDNA Clones/MolecularCloud

Downregulation of miR-1-3p expression inhibits the hypertrophy and mineralization of chondrocytes in DDH

Authors: Rui Ding, Xijuan Liu, Jian Zhang, Jinghong Yuan, Sikuan Zheng, Xigao Cheng, Jingyu Jia

Journal: J Orthop Surg Res

PubMed ID: 34407854

Doi: 10.1186/s13018-021-02666-1

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Mapping human calreticulin regions important for structural stability

Authors: Evaldas Čiplys, Tautvydas Paškevičius, Eimantas Žitkus, Juras Bielskis, Raimundas Ražanskas, Tomas Šneideris, Vytautas Smirnovas, Algirdas Kaupinis, David J Tester, Michael J Ackerman, Peter Højrup, Marek Michalak, Gunnar Houen, Rimantas Slibinskas

Journal: Biochim Biophys Acta Proteins Proteom

PubMed ID: 34358706

Doi: 10.1016/j.bbapap.2021.140710

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Inhibition of Border Disease Virus Replication With Lentivirus-Mediated shRNAs

Authors: Mohammad Javad Hajihasani Arani, Azam Mokhtari, Behnaz Saffar, Leila Asadi Samani

Journal: Front Vet Sci

PubMed ID: 34447803

Doi: 10.3389/fvets.2021.708591

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Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells

Authors: Konrad Klockmeier, Eduardo Silva Ramos, Tamás Raskó, Adrián Martí Pastor, Erich E Wanker

Journal: J Mol Biol

PubMed ID: 34364876

Doi: 10.1016/j.jmb.2021.167184

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Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

Authors: Chee-Wah Tan, Wan-Ni Chia, Barnaby E Young, Feng Zhu, Beng-Lee Lim, Wan-Rong Sia, Tun-Linn Thein, Mark I-C Chen, Yee-Sin Leo, David C Lye, Lin-Fa Wang

Journal: N Engl J Med

PubMed ID: 34407341

Doi: 10.1056/NEJMoa2108453

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Early warning and rapid public health response to prevent COVID-19 outbreaks in long-term care facilities (LTCF) by monitoring SARS-CoV-2 RNA in LTCF site-specific sewage samples and assessment of antibodies response in this population: prospective study protocol

Authors: Bonita E Lee, Christopher Sikora, Douglas Faulder, Eleanor Risling, Lorie A Little, Yuanyuan Qiu, Tiejun Gao, Ross Bulat, Stephen Craik, Steve E Hrudey, Arto Ohinmaa, Carole A Estabrooks, Anne-Claude Gingras, Carmen Charlton, John Kim, Heidi Wood, Alyssia Robinson, Jamil N Kanji, Nathan Zelyas, Sheila F O'Brien, Steven Drews, Xiao-Li Pang

Journal: BMJ Open

PubMed ID: 34417219

Doi: 10.1136/bmjopen-2021-052282

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Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains

Authors: Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Hae-Ahm Lee, Eun-Kyung Moon, Beom-Ku Han, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 34452044

Doi: 10.3390/vaccines9080920

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Metabolic Engineering of BD16 for Heterologous Expression of Synthetic Gene Cassette and L-Alanine Production in the Recombinant Strain Using Fed-Batch Fermentation

Authors: Anshula Sharma, Masafumi Noda, Masanori Sugiyama, Baljinder Kaur, Ajaz Ahmad

Journal: Foods

PubMed ID: 34441741

Doi: 10.3390/foods10081964

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miRNA-451 regulates the NF-κB signaling pathway by targeting IKKβ to inhibit glioma cell growth

Authors: Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang

Journal: Cell Cycle

PubMed ID: 34463194

Doi: 10.1080/15384101.2021.1969496

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Litopenaeus vannamei peroxiredoxin 2-like is involved in WSSV infection by interaction with wsv089 and VP26

Authors: Xing-Chao Ren, Xiao-Ping Liu, Qing-Hui Liu

Journal: Dev Comp Immunol

PubMed ID: 34450129

Doi: 10.1016/j.dci.2021.104243

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A continuous spectrophotometric assay for glutathione-independent glyoxalases

Authors: Tomiris Mulikova, Zhanibek Bekkhozhin, Aizat Abdirassil, Darkhan Utepbergenov

Journal: Anal Biochem

PubMed ID: 34391725

Doi: 10.1016/j.ab.2021.114317

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Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP

Authors: Mark Chen, Joseph P Foster, Ian C Lock, Nathan H Leisenring, Andrea R Daniel, Warren Floyd, Eric Xu, Ian J Davis, David G Kirsch

Journal: Cancer Res

PubMed ID: 34385184

Doi: 10.1158/0008-5472.CAN-20-1497

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