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Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells

Authors: Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen

Journal: Bioengineered

PubMed ID: 33818278

Doi: 10.1080/21655979.2021.1905259

Products & Services: Recombinant Proteins

Physicochemical and molecular transformation of novel functional peptides from Baijiu

Authors: Wei Jia, An Du, Xiaojun Dong, Zibian Fan, Duimin Zhang, Ruihong Wang, Lin Shi

Journal: Food Chem

PubMed ID: 34954580

Doi: 10.1016/j.foodchem.2021.131894

Products & Services: Peptide Synthesis

Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429

Authors: Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Jinfang Liu, Jianlan Liu, Jian Tang, Gang Yao

Journal: Bioengineered

PubMed ID: 34288815

Doi: 10.1080/21655979.2021.1953822

Products & Services: Protein Electrophoresis and Western

Long non-coding RNA SNHG5 regulates ulcerative colitis via microRNA-375 / Janus kinase-2 axis

Authors: Hui Li, Ji Xuan, Wei Zhang, Zhentao An, Xinyu Fan, Min Lu, Yaozhou Tian

Journal: Bioengineered

PubMed ID: 34334085

Doi: 10.1080/21655979.2021.1953219

Products & Services: Protein and Antibody Isolation

Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application

Authors: Nattihda Parakasikron, Chatchai Chaotham, Pithi Chanvorachote, Chanida Vinayanuwattikun, Visarut Buranasudja, Pornchanok Taweecheep, Kannika Khantasup

Journal: Drug Deliv

PubMed ID: 34236266

Doi: 10.1080/10717544.2021.1943055

Products & Services: Plasmid DNA Preparation

microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis

Authors: Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yang

Journal: Adipocyte

PubMed ID: 34311651

Doi: 10.1080/21623945.2021.1938829

Products & Services: Mutant Libraries

Mesenchymal Stem/Stromal Cells Overexpressing CXCR4 Revealed Enhanced Migration: A Lesson Learned from the Pathogenesis of WHIM Syndrome

Authors: Hamid Reza Bidkhori, Ahmad Reza Bahrami, Moein Farshchian, Asieh Heirani-Tabasi, Mahdi Mirahmadi, Halimeh Hasanzadeh, Naghmeh Ahmadiankia, Reza Faridhosseini, Mahtab Dastpak, Arezoo Gowhari Shabgah, Maryam M Matin

Journal: Cell Transplant

PubMed ID: 34807749

Doi: 10.1177/09636897211054498

Products & Services: Mutagenesis Services

Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines

Authors: Sunil Kumar, Priyanka Singh, Awanish Kumar

Journal: Clin J Gastroenterol

PubMed ID: 34862947

Doi: 10.1007/s12328-021-01555-8

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Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis

Authors: Bing Chen, Haoran Wang, Chenglin Lv, Chongdan Mao, Yuguang Cui

Journal: Bioengineered

PubMed ID: 34288826

Doi: 10.1080/21655979.2021.1951070

Products & Services: Gene Synthesis

Rapid test to assess the escape of SARS-CoV-2 variants of concern

Authors: Jacob T Heggestad, Rhett J Britton, David S Kinnamon, Simone A Wall, Daniel Y Joh, Angus M Hucknall, Lyra B Olson, Jack G Anderson, Anna Mazur, Cameron R Wolfe, Thomas H Oguin, Bruce A Sullenger, Thomas W Burke, Bryan D Kraft, Gregory D Sempowski, Christopher W Woods, Ashutosh Chilkoti

Journal: Sci Adv

PubMed ID: 34860546

Doi: 10.1126/sciadv.abl7682

Products & Services: Recombinant Proteins

Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond

Authors: Qiuping Zhang, Yanni Wang, Zongyuan Wang, Eyad Abdulwhab Hamoud Mohammed, Quanyi Zhao, Dian He, Zhen Wang

Journal: Bioorg Chem

PubMed ID: 34902645

Doi: 10.1016/j.bioorg.2021.105542

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sp nov, a novel phenylacetic acid degrading bacterium isolated from sludge

Authors: Fa-Hu Pang, Hui-Ying Yang, Jie Sun, Xing Yu, Hao Zhang

Journal: Int J Syst Evol Microbiol

PubMed ID: 34878373

Doi: 10.1099/ijsem.0.005144

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KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Authors: Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F Meckler, Ryan R Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G Tepper, Ken-Ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya

Journal: Commun Biol

PubMed ID: 34857874

Doi: 10.1038/s42003-021-02853-0

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A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes

Authors: Jing-Jing Xu, Xiao-Fan Zhang, Yan Jiang, Hang Fan, Jian-Xu Li, Chen-Yi Li, Qing Zhao, Lei Yang, Yong-Hong Hu, Cathie Martin, Xiao-Ya Chen

Journal: Sci Adv

PubMed ID: 34878842

Doi: 10.1126/sciadv.abl3594

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Population genetics of cycas necrotic stunt virus and the development of multiplex RT-PCR diagnostics

Authors: Cullen M Shaffer, David C Michener, Nastassia B Vlasava, Henry Chotkowski, Ioannis E Tzanetakis

Journal: Virus Res

PubMed ID: 34906655

Doi: 10.1016/j.virusres.2021.198655

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Humoral and cellular immune responses to the SARS-CoV-2 BNT162b2 vaccine among a cohort of solid organ transplant recipients and healthy controls

Authors: Ahmad Yanis, Zaid Haddadin, Andrew J Spieker, Danya Waqfi, Danielle A Rankin, Rana Talj, Lora Thomas, Kelly A Birdwell, Lauren Ezzell, Marcia Blair, Joan Eason, Rebekkah Varjabedian, Christian M Warren, Cynthia H Nochowicz, Eric C Olson, Joshua D Simmons, Sandra Yoder, Madeline Guy, Isaac Thomsen, James D Chappell, Spyros A Kalams, Natasha B Halasa

Journal: Transpl Infect Dis

PubMed ID: 34905653

Doi: 10.1111/tid.13772

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A de novo ACTB gene pathogenic variant in identical twins with phenotypic variation for hydrops and jejunal atresia

Authors: Kristina Sibbin, Patrick Yap, Denis Nyaga, Raoul Heller, Stephen Evans, Kate Strachan, Salam Alburaiky, Han M Alex Nguyen, Sylvie Hermann-Le Denmat, Austen R D Ganley, Justin M O'Sullivan, Frank H Bloomfield

Journal: Am J Med Genet A

PubMed ID: 34970864

Doi: 10.1002/ajmg.a.62631

Products & Services: Plasmid DNA Preparation

Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile

Authors: Daniel Rehling, Emma Rose Scaletti, Inna Rozman Grinberg, Daniel Lundin, Margareta Sahlin, Anders Hofer, Britt-Marie Sjöberg, Pål Stenmark

Journal: Biochemistry

PubMed ID: 34941255

Doi: 10.1021/acs.biochem.1c00503

Products & Services: PCR Cloning and Subcloning

A Highly Conserved Peptide Vaccine Candidate Activates Both Humoral and Cellular Immunity Against SARS-CoV-2 Variant Strains

Authors: Fengxia Gao, Jingjing Huang, Tingting Li, Chao Hu, Meiying Shen, Song Mu, Feiyang Luo, Shuyi Song, Yanan Hao, Wang Wang, Xiaojian Han, Chen Qian, Yingming Wang, Ruixin Wu, Luo Li, Shenglong Li, Aishun Jin

Journal: Front Immunol

PubMed ID: 34950151

Doi: 10.3389/fimmu.2021.789905

Products & Services: Protein and Antibody Isolation

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model

Authors: Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata

Journal: Mol Ther Oncolytics

PubMed ID: 35024435

Doi: 10.1016/j.omto.2021.12.003

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Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1

Authors: Kyung-Mi Choi, Jung Hak Kim, Xiangmudong Kong, Meltem Isik, Jin Zhang, Hee-Woong Lim, John C Yoon

Journal: Cell Rep

PubMed ID: 34910916

Doi: 10.1016/j.celrep.2021.110104

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Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses

Authors: Belén Aparicio, Noelia Casares, Josune Egea, Marta Ruiz, Diana Llopiz, Sheila Maestro, Cristina Olagüe, Gloria González-Aseguinolaza, Cristian Smerdou, Ascensión López-Díaz de Cerio, Susana Inogés, Felipe Prósper, José R Yuste, Francisco Carmona-Torre, Gabriel Reina, Juan J Lasarte, Pablo Sarobe

Journal: Emerg Microbes Infect

PubMed ID: 34538222

Doi: 10.1080/22221751.2021.1978823

Products & Services: Mammalian Expression

Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

Authors: Zhen-Tao Mo, Jie Zheng, Yu-Ling Liao

Journal: Pharm Biol

PubMed ID: 34711127

Doi: 10.1080/13880209.2021.1991959

Products & Services: Plasmid DNA Preparation

VLDLR and ApoER2 are receptors for multiple alphaviruses

Authors: Lars E Clark, Sarah A Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine G Nabel, Pan Yang, Dylan V Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, Kenneth S Plante, Asim A Ahmed, Flaminia Catteruccia, Tracy L Young-Pearse, Isaac M Chiu, Paula Montero Llopis, Scott C Weaver, Jonathan Abraham

Journal: Nature

PubMed ID: 34929721

Doi: 10.1038/s41586-021-04326-0

Products & Services: Mammalian Expression

Bombyx mori Nucleopolyhedrovirus (BmNPV) Induces G2/M Arrest to Promote Viral Multiplication by Depleting

Authors: Qin Xiao, Zhan-Qi Dong, Yan Zhu, Qian Zhang, Xiu Yang, Miao Xiao, Peng Chen, Cheng Lu, Min-Hui Pan

Journal: Insects

PubMed ID: 34940186

Doi: 10.3390/insects12121098

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Identification and Characterization Analysis of Transient Receptor Potential Mucolipin Protein of Fallén

Authors: Haitao Wang, Yan Dong, Baijie Wan, Yinghua Ji, Qiufang Xu

Journal: Insects

PubMed ID: 34940195

Doi: 10.3390/insects12121107

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Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

Authors: Tea Pemovska, Johannes W Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrián César-Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp B Staber, Giulio Superti-Furga

Journal: Nat Commun

PubMed ID: 34907165

Doi: 10.1038/s41467-021-27329-x

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Calibration of two validated SARS-CoV-2 pseudovirus neutralization assays for COVID-19 vaccine evaluation

Authors: Yunda Huang, Oleg Borisov, Jia Jin Kee, Lindsay N Carpp, Terri Wrin, Suqin Cai, Marcella Sarzotti-Kelsoe, Charlene McDanal, Amanda Eaton, Rolando Pajon, John Hural, Christine M Posavad, Katherine Gill, Shelly Karuna, Lawrence Corey, M Juliana McElrath, Peter B Gilbert, Christos J Petropoulos, David C Montefiori

Journal: Sci Rep

PubMed ID: 34907214

Doi: 10.1038/s41598-021-03154-6

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Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

Authors: Lawrence T Wang, Lais S Pereira, Patience K Kiyuka, Arne Schön, Neville K Kisalu, Rachel Vistein, Marlon Dillon, Brian G Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H Idris, Joseph R Francica, Robert A Seder

Journal: PLoS Pathog

PubMed ID: 34871332

Doi: 10.1371/journal.ppat.1010133

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Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation

Authors: Yonghong Luo, Yanhong Guo, Huilun Wang, Minzhi Yu, Kristen Hong, Dan Li, Ruiting Li, Bo Wen, Die Hu, Lin Chang, Jifeng Zhang, Bo Yang, Duxin Sun, Anna S Schwendeman, Y Eugene Chen

Journal: EBioMedicine

PubMed ID: 34879325

Doi: 10.1016/j.ebiom.2021.103725

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Oxidation of Various Kraft Lignins with a Bacterial Laccase Enzyme

Authors: Sebastian A Mayr, Raditya Subagia, Renate Weiss, Nikolaus Schwaiger, Hedda K Weber, Johannes Leitner, Doris Ribitsch, Gibson S Nyanhongo, Georg M Guebitz

Journal: Int J Mol Sci

PubMed ID: 34884966

Doi: 10.3390/ijms222313161

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Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

Authors: Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki

Journal: PLoS Pathog

PubMed ID: 34882757

Doi: 10.1371/journal.ppat.1010085

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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Authors: Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman

Journal: PLoS Biol

PubMed ID: 34879065

Doi: 10.1371/journal.pbio.3001474

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Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis

Authors: Oyindamola O Adefisayo, Pierre Dupuy, Astha Nautiyal, James M Bean, Michael S Glickman

Journal: Nucleic Acids Res

PubMed ID: 34871411

Doi: 10.1093/nar/gkab1169

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Development and characterization of efficient xylose utilization strains of Zymomonas mobilis

Authors: Jiyun Lou, Jingwen Wang, Yongfu Yang, Qing Yang, Runxia Li, Mimi Hu, Qiaoning He, Jun Du, Xia Wang, Mian Li, Shihui Yang

Journal: Biotechnol Biofuels

PubMed ID: 34863266

Doi: 10.1186/s13068-021-02082-x

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GR-mediated transcriptional regulation of mA metabolic genes contributes to diet-induced fatty liver in hens

Authors: Yue Feng, Yanlin Li, Wenduo Jiang, Yun Hu, Yimin Jia, Ruqian Zhao

Journal: J Anim Sci Biotechnol

PubMed ID: 34872591

Doi: 10.1186/s40104-021-00642-7

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The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Authors: Paolo Mesén-Ramírez, Bärbel Bergmann, Mourad Elhabiri, Lei Zhu, Heidrun von Thien, Carolina Castro-Peña, Tim-Wolf Gilberger, Elisabeth Davioud-Charvet, Zbynek Bozdech, Anna Bachmann, Tobias Spielmann

Journal: Cell Host Microbe

PubMed ID: 34863371

Doi: 10.1016/j.chom.2021.11.002

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The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

Authors: Gergely Rona, Andras Zeke, Bearach Miwatani-Minter, Maren de Vries, Ramanjit Kaur, Austin Schinlever, Sheena Faye Garcia, Hailey V Goldberg, Hui Wang, Thomas R Hinds, Fabrice Bailly, Ning Zheng, Philippe Cotelle, Didier Desmaële, Nathaniel R Landau, Meike Dittmann, Michele Pagano

Journal: Cell Death Differ

PubMed ID: 34862481

Doi: 10.1038/s41418-021-00900-1

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FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Authors: Ioanna A Rota, Adam E Handel, Stefano Maio, Fabian Klein, Fatima Dhalla, Mary E Deadman, Stanley Cheuk, Joseph A Newman, Yale S Michaels, Saulius Zuklys, Nicolas Prevot, Philip Hublitz, Philip D Charles, Athina Soragia Gkazi, Eleni Adamopoulou, Waseem Qasim, Edward Graham Davies, Imelda Hanson, Alistair T Pagnamenta, Carme Camps, Helene M Dreau, Andrea White, Kieran James, Roman Fischer, Opher Gileadi, Jenny C Taylor, Tudor Fulga, B Christoffer Lagerholm, Graham Anderson, Erdinc Sezgin, Georg A Holländer

Journal: Sci Adv

PubMed ID: 34860543

Doi: 10.1126/sciadv.abj9247

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34853399

Doi: 10.1038/s42003-021-02866-9

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Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Authors: Elif Karaaslan, Nesibe Selma Çetin, Merve Kalkan-Yazıcı, Sevde Hasanoğlu, Faruk Karakeçili, Aykut Özdarendeli, Ahmet Kalkan, Ali Osman Kılıç, Mehmet Ziya Doymaz

Journal: PLoS Negl Trop Dis

PubMed ID: 34851958

Doi: 10.1371/journal.pntd.0009973

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LncRNA FOXP4-AS1 Promotes the Progression of Esophageal Squamous Cell Carcinoma by Interacting With MLL2/H3K4me3 to Upregulate FOXP4

Authors: Yunfeng Niu, Gaoyan Wang, Yan Li, Wei Guo, Yanli Guo, Zhiming Dong

Journal: Front Oncol

PubMed ID: 34970490

Doi: 10.3389/fonc.2021.773864

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-Encoding Protein Is the Only Chemoreceptor That Regulates Chemoattraction toward the Broad Antibacterial Agent Formic Acid

Authors: Hao Wang, Mengqi Zhang, Yujuan Xu, Renjie Zong, Nan Xu, Minliang Guo

Journal: Biology (Basel)

PubMed ID: 34943260

Doi: 10.3390/biology10121345

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ASCVac-1, a Multi-Peptide Chimeric Vaccine, Protects Mice Against Infection

Authors: Ana Clara Gazzinelli-Guimarães, Denise Silva Nogueira, Chiara Cássia Oliveira Amorim, Fabrício Marcus Silva Oliveira, Anderson Coqueiro-Dos-Santos, Samuel Alexandre Pimenta Carvalho, Lucas Kraemer, Fernando Sérgio Barbosa, Vanessa Gomes Fraga, Flaviane Vieira Santos, Joseane Camilla de Castro, Remo Castro Russo, Milena Apetito Akamatsu, Paulo Lee Ho, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara

Journal: Front Immunol

PubMed ID: 34992603

Doi: 10.3389/fimmu.2021.788185

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Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae

Authors: Yong-Shui Tan, Li Wang, Ying-Ying Wang, Qi-En He, Zhi-Hua Liu, Zhen Zhu, Kai Song, Bing-Zhi Li, Ying-Jin Yuan

Journal: Biotechnol Biofuels

PubMed ID: 34920742

Doi: 10.1186/s13068-021-02090-x

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Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury

Authors: Qing Hou, Weibo Le, Shuyan Kan, Jinsong Shi, Yue Lang, Zhihong Liu, Zhaohong Chen

Journal: Front Cell Dev Biol

PubMed ID: 35004680

Doi: 10.3389/fcell.2021.781792

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Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral

Authors: Jianqing Xu, Zhihong Ren, Kangli Cao, Xianping Li, Jing Yang, Xuelian Luo, Lingyan Zhu, Xiangwei Wang, Longfei Ding, Junrong Liang, Dong Jin, Tingting Yuan, Lianfeng Li, Jianguo Xu

Journal: Front Nutr

PubMed ID: 35004816

Doi: 10.3389/fnut.2021.789242

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New lessons on TDP-43 from old N furzeri killifish

Authors: Alexandra Louka, Sara Bagnoli, Jakob Rupert, Benjamin Esapa, Gian Gaetano Tartaglia, Alessandro Cellerino, Annalisa Pastore, Eva Terzibasi Tozzini

Journal: Aging Cell

PubMed ID: 34939315

Doi: 10.1111/acel.13517

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Isolation of Healthy F4/80+ Macrophages from Embryonic day E135 Mouse Fetal Liver Using Magnetic Nanoparticles for Single Cell Sequencing

Authors: Kaustav Mukherjee, James J Bieker

Journal: Bio Protoc

PubMed ID: 35005088

Doi: 10.21769/BioProtoc.4243

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Mining Marine Metagenomes Revealed a Quorum-Quenching Lactonase with Improved Biochemical Properties That Inhibits the Food Spoilage Bacterium Pseudomonas fluorescens

Authors: Rami Haramati, Shlomit Dor, David Gurevich, Doron Levy, Dekel Freund, Giora Rytwo, Itai Sharon, Livnat Afriat-Jurnou

Journal: Appl Environ Microbiol

PubMed ID: 34910563

Doi: 10.1128/AEM.01680-21

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Long non‑coding RNA LINC01748 exerts carcinogenic effects in non‑small cell lung cancer cell lines by regulating the microRNA‑520a‑5p/HMGA1 axis

Authors: Yinling Tan, Fengxia Xu, Lingling Xu, Jianying Cui

Journal: Int J Mol Med

PubMed ID: 34970695

Doi: 10.3892/ijmm.2021.5077

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Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles

Authors: Andrew K Swansiger, Michael T Marty, James S Prell

Journal: J Am Soc Mass Spectrom

PubMed ID: 34913687

Doi: 10.1021/jasms.1c00317

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Preparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha

Authors: Xinmei Liao, Hui Liang, Jian Pan, Qian Zhang, Jiaqi Niu, Cuili Xue, Jian Ni, Daxiang Cui

Journal: Bioengineered

PubMed ID: 34886761

Doi: 10.1080/21655979.2021.1967710

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HMGA2 promotes the migration and invasion of gallbladder cancer cells and HMGA2 knockdown inhibits angiogenesis via targeting VEGFA

Authors: Jun Yan, Peng Dai, Xueliang Qin, Yanping He, Yu Zhang

Journal: Mol Med Rep

PubMed ID: 34913073

Doi: 10.3892/mmr.2021.12570

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Development of a recombinant nucleocapsid protein-based ELISA for the detection of IgM and IgG antibodies to SARS-CoV-2

Authors: Maryam Ranjbar, Marzieh Asadi, Marjan Nourigorji, Bahador Sarkari, Zohreh Mostafavi-Pour, Kamiar Zomorodian, Zahra Shabaninejad, Mortaza Taheri-Anganeh, Amir Maleksabet, Mohsen Moghadami, Amir Savardashtaki

Journal: Biotechnol Appl Biochem

PubMed ID: 34965611

Doi: 10.1002/bab.2308

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Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: biorxiv

PubMed ID: 34909777

Doi: 10.1101/2021.12.06.471455

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Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus

Authors: Jiao Lan, Ke Li, Austin Gresham, Jifei Miao

Journal: Eur J Pharmacol

PubMed ID: 34896110

Doi: 10.1016/j.ejphar.2021.174693

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Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

Authors: Jingru Guo, Yujing Bai, Yunxie Wei, Yabin Dong, Hongqiu Zeng, Russel J Reiter, Haitao Shi

Journal: J Pineal Res

PubMed ID: 34936113

Doi: 10.1111/jpi.12784

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Cryopreservation of network bioactivity and multi-lineage stromal cell differentiation potential within three-dimensional synthetic hydrogels

Authors:

Journal: Cryobiology

PubMed ID: 34922883

Doi: 10.1016/j.cryobiol.2021.12.003

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Deferasirox combination with eltrombopag shows anti-myelodysplastic syndrome effects by enhancing iron deprivation-related apoptosis

Authors: Lei Huang, Mengyue Tian, Zhaoyun Liu, Chunyan Liu, Rong Fu

Journal: J Investig Med

PubMed ID: 34921125

Doi: 10.1136/jim-2021-002147

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Comparative analysis of mussel foot protein 3B co-expressed with tyrosinases provides a potential adhesive biomaterial

Authors: Lin Yao, Xinyi Wang, Rui Xue, Hong Xu, Rui Wang, Lujia Zhang, Sha Li

Journal: Int J Biol Macromol

PubMed ID: 34896153

Doi: 10.1016/j.ijbiomac.2021.11.208

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Developing a secretory AcGFP1-based IRES expression system for efficient production of mammalian recombinant proteins

Authors: Zhongcheng Zou, Matthew Spencer, Peter D Sun

Journal: Protein Expr Purif

PubMed ID: 34920134

Doi: 10.1016/j.pep.2021.106029

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The key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus

Authors: Dan Wang, Zhanmin Sun, Xinxu Hu, Junbo Xiong, Lizhen Hu, Yuandong Xu, Yixiong Tang, Yanmin Wu

Journal: BMC Plant Biol

PubMed ID: 34965872

Doi: 10.1186/s12870-021-03336-4

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The ecdysteroid receptor regulates salivary gland degeneration through apoptosis in Rhipicephalus haemaphysaloides

Authors: Xiaojuan Lu, Zhipeng Zhang, Dongqi Yuan, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Itabajara da Silva Vaz, Jinlin Zhou

Journal: Parasit Vectors

PubMed ID: 34930413

Doi: 10.1186/s13071-021-05052-2

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Exposure to in Asian Elephants () in Thailand

Authors: Ruenruetai Udonsom, Yoshifumi Nishikawa, Ragab M Fereig, Thitirat Topisit, Natchakorn Kulkaweewut, Supitcha Chanamrung, Charoonluk Jirapattharasate

Journal: Pathogens

PubMed ID: 35055950

Doi: 10.3390/pathogens11010002

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Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers

Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen

Journal: Hum Mutat

PubMed ID: 34923709

Doi: 10.1002/humu.24321

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Increased sensitivity of gp210 autoantibody detection using a newly designed gp210 antigen

Authors: Jing Xu, Haoyi Zhang, Chan Wang, Peng Jiang, Chongxu Han, Yaping Dai, Fang Qiu, Yuhua Gong, Yuzhang Jiang, Ping Xu, Mingming Zhang, Luyao Zhang, Xingjuan Shi, Sufang Chen, Ye Tian, Michael F Seldin, M Eric Gershwin, Xiangdong Liu, Li Li

Journal: J Immunol Methods

PubMed ID: 34971632

Doi: 10.1016/j.jim.2021.113211

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Increased sensitivity of gp210 autoantibody detection using a newly designed gp210 antigen

Journal: J Immunol Methods

PubMed ID: 34971632

Doi: 10.1016/j.jim.2021.113211

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CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients

Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Samuele Tardito

Journal: Arthritis Res Ther

PubMed ID: 34952630

Doi: 10.1186/s13075-021-02691-9

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The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism

Authors: Jennifer A Buffa, Kymberleigh A Romano, Matthew F Copeland, David B Cody, Weifei Zhu, Rachel Galvez, Xiaoming Fu, Kathryn Ward, Marc Ferrell, Hong J Dai, Sarah Skye, Ping Hu, Lin Li, Mirjana Parlov, Amy McMillan, Xingtao Wei, Ina Nemet, Robert A Koeth, Xinmin S Li, Zeneng Wang, Naseer Sangwan, Adeline M Hajjar, Mohammed Dwidar, Taylor L Weeks, Nathalie Bergeron, Ronald M Krauss, W H Wilson Tang, Federico E Rey, Joseph A DiDonato, Valentin Gogonea, G Frank Gerberick, Jose Carlos Garcia-Garcia, Stanley L Hazen

Journal: Nat Microbiol

PubMed ID: 34949826

Doi: 10.1038/s41564-021-01010-x

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Structural Insight into the Mechanism of PALB2 Interaction with MRG15

Authors: Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

Journal: Genes (Basel)

PubMed ID: 34946951

Doi: 10.3390/genes12122002

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Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs

Authors: Giovanni Romito, Elena Venturelli, Vanna Tintorri, Mario Cipone

Journal: J Vet Med Sci

PubMed ID: 34955461

Doi: 10.1292/jvms.21-0571

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CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study

Authors: Yazdan Rahmati, Hasan Mollanoori, Sajad Najafi, Sajjad Esmaeili, Mohammad Reza Alivand

Journal: BMC Pediatr

PubMed ID: 34895171

Doi: 10.1186/s12887-021-03003-5

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Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)

Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller

Journal: Biophys Chem

PubMed ID: 34953381

Doi: 10.1016/j.bpc.2021.106745

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Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway

Authors: Dan Su, Chunye Lv

Journal: Bioengineered

PubMed ID: 34889713

Doi: 10.1080/21655979.2021.2009965

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Dynamic Distribution of HIG2A between the Mitochondria and the Nucleus in Response to Hypoxia and Oxidative Stress

Authors: Celia Salazar, Miriam Barros, Alvaro A Elorza, Lina María Ruiz

Journal: Int J Mol Sci

PubMed ID: 35008815

Doi: 10.3390/ijms23010389

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Glycoside Hydrolase family 30 harbors fungal subfamilies with distinct polysaccharide specificities

Authors: Xinxin Li, Dimitrios Kouzounis, Mirjam A Kabel, Ronald P de Vries, Adiphol Dilokpimol

Journal: N Biotechnol

PubMed ID: 34952234

Doi: 10.1016/j.nbt.2021.12.004

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Cloning, Expression and Inhibitory Effects on Lewis Lung Carcinoma Cells of rAj-Tspin from Sea Cucumber ()

Authors: Rong Qiao, Rong Xiao, Zhong Chen, Jingwei Jiang, Chenghua Yuan, Shuxiang Ning, Jihong Wang, Zunchun Zhou

Journal: Molecules

PubMed ID: 35011462

Doi: 10.3390/molecules27010229

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Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles

Authors: Guangze Yang+ , Yun Liu+ , Yue Hui, Tengjisi, Dong Chen, David A. Weitz, and Chun-Xia Zhao

Journal: ANGEWANDTE CHEMIE

Doi: doi.org/10.1002/anie.202101730

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A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern

Authors: Shahbaz Ahmed, Mohammad Suhail Khan, Savitha Gayathri, Randhir Singh, Sahil Kumar, Unnatiben Rajeshbhai Patel, Sameer Kumar Malladi, Raju S Rajmani, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Nidhi Girish, Poorvi Reddy, Aditya Upadhyaya, Suman Pandey, Samreen Siddiqui, Akansha Tyagi, Sujeet Jha, Rajesh Pandey, Oyahida Khatun, Rohan Narayan, Shashank Tripathi, Alexander J McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S Vasan, Rajesh P Ringe, Raghavan Varadarajan

Journal: Front Immunol

PubMed ID: 34956193

Doi: 10.3389/fimmu.2021.765211

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Progressing Ultragreen, Energy-Efficient Biobased Depolymerization of Poly(ethylene terephthalate) via Microwave-Assisted Green Deep Eutectic Solvent and Enzymatic Treatment

Authors: Olivia A Attallah, Muhammad Azeem, Efstratios Nikolaivits, Evangelos Topakas, Margaret Brennan Fournet

Journal: Polymers (Basel)

PubMed ID: 35012131

Doi: 10.3390/polym14010109

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Repertoire-scale antibody structural prediction informs therapeutic design

Authors: Zhe Sang; Yufei Xiang; Wei Huang; Paul R. Sargunas; Yong Joon (Jeffery) Kim; Zirui Feng; Derek J. Taylor; Yi Shi

Journal: SCIENCE ADVANCES

PubMed ID: 42030385

Doi: 10.1126/sciadv.aef7163

Angiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway

Authors: Liying Dai, Shuangshuang Jie, Shaohua Bi, Qing Qing, Jun Chen

Journal: Bioengineered

PubMed ID: 34565297

Doi: 10.1080/21655979.2021.1985341

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A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity

Authors: Edel Pérez-López, Md Musharaf Hossain, Yangdou Wei, Christopher D Todd, Peta C Bonham-Smith

Journal: Virulence

PubMed ID: 34515618

Doi: 10.1080/21505594.2021.1968684

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Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity

Authors: Tamara Ratovitski, Mali Jiang, Robert N O'Meally, Priyanka Rauniyar, Ekaterine Chighladze, Anikó Faragó, Siddhi V Kamath, Jing Jin, Alexey V Shevelkin, Robert N Cole, Christopher A Ross

Journal: Hum Mol Genet

PubMed ID: 34888656

Doi: 10.1093/hmg/ddab351

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TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

Authors: Parminder Kaur, Ryan Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang

Journal: Nucleic Acids Res

PubMed ID: 34883513

Doi: 10.1093/nar/gkab1142

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Vascular endothelial growth factor-c regulates hematopoietic stem cell fate in the dorsal aorta

Authors: Rebecca K Schiavo, Owen J Tamplin

Journal: Development

PubMed ID: 34919128

Doi: 10.1242/dev.199498

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LncRNA-IRAR-mediated regulation of insulin receptor transcripts in Drosophila melanogaster during nutritional stress

Authors: Jie Chen, Yuantai Huang, Guojun Qi

Journal: Insect Mol Biol

PubMed ID: 34923706

Doi: 10.1111/imb.12756

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MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma

Authors: Hui Liu, Zuofei Chi, Hong Jin, Wei Yang

Journal: Bioengineered

PubMed ID: 33944676

Doi: 10.1080/21655979.2021.1920325

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Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C-type lectin receptor Langerin

Authors: Lydia Bellmann, Helen Strandt, Claudia Zelle-Rieser, Daniela Ortner, Christoph H Tripp, Sandra Schmid, Julia Rühl, Giuseppe Cappellano, Sandra Schaffenrath, Anastasia Prokopi, Sarah Spoeck, Athanasios Seretis, Barbara Del Frari, Stephan Sigl, Johanna Krapf, Christine Heufler, Tibor Keler, Christian Münz, Nikolaus Romani, Patrizia Stoitzner

Journal: Eur J Immunol

PubMed ID: 34932821

Doi: 10.1002/eji.202149670

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Sustained but Declining Humoral Immunity Against SARS-CoV-2 at 9 Months Postvaccination With BNT162b2: A Prospective Evaluation in 309 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Filia Apostolakou, Sentiljana Gumeni, Maria Gavriatopoulou, Dimitris Papadopoulos, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Eleni Korompoki, Efstathios Kastritis, Ioannis Papassotiriou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: HemaSphere

PubMed ID: 34938959

Doi: 10.1097/HS9.0000000000000677

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Dual-detection fluorescent immunochromatographic assay for quantitative detection of SARS-CoV-2 spike RBD-ACE2 blocking neutralizing antibody

Authors: Xuejun Duan, Yijun Shi, Xudong Zhang, Xiaoxiao Ge, Rong Fan, Jinghan Guo, Yubin Li, Guoge Li, Yaowei Ding, Rasha Alsamani Osman, Wencan Jiang, Jialu Sun, Xin Luan, Guojun Zhang

Journal: Biosens Bioelectron

PubMed ID: 34942543

Doi: 10.1016/j.bios.2021.113883

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CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8

Authors: Marina Serna, Ana González-Corpas, Sofía Cabezudo, Andrés López-Perrote, Gianluca Degliesposti, Eduardo Zarzuela, J Mark Skehel, Javier Muñoz, Oscar Llorca

Journal: Nucleic Acids Res

PubMed ID: 34951455

Doi: 10.1093/nar/gkab1267

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Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA

Authors: Kun Huang, Xiao-Xian Wu, Cheng-Li Fang, Zhou-Geng Xu, Hong-Wei Zhang, Jian Gao, Chuan-Miao Zhou, Lin-Lin You, Zhan-Xi Gu, Wen-Hui Mu, Yu Feng, Jia-Wei Wang, Yu Zhang

Journal: Science

PubMed ID: 34941388

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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Authors: Edmond M Linossi , Kunlun Li , Gianluca Veggiani , Cyrus Tan , Farhad Dehkhoda , Colin Hockings , Dale J Calleja , Narelle Keating , Rebecca Feltham , Andrew J Brooks , Shawn S Li , Sachdev S Sidhu , Jeffrey J Babon , Nadia J Kershaw , Sandra E Nicholson

Journal: Nat Commun

PubMed ID: 34857742

Doi: s41467-021-26983-5

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Blood virosphere in febrile Tanzanian children

Authors: Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D'Acremont, Laurent Kaiser

Journal: Emerg Microbes Infect

PubMed ID: 33929935

Doi: 10.1080/22221751.2021.1925161

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Long-term trajectories of SARS-CoV-2 neutralizing antibodies and predictive value of first dose vaccination-induced IgG-antibodies in hemodialysis patients

Authors: F P Tillmann, H Still, Philipp von Landenberg

Journal: Int Urol Nephrol

PubMed ID: 34860338

Doi: 10.1007/s11255-021-03076-2

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Impaired Immune Response to COVID-19 Vaccination in Patients with B-Cell Malignancies after CD19 CART Cell Therapy

Authors: Saurabh Dahiya, Tim Luetkens, Forat Lutfi, Stephanie V Avila, Thierry Iraguha, Philip J Margiotta, Kim G Hankey, Patricia Lesho, Jennie Y Law, Seung Tae Lee, John W Baddley, Mehmet Hakan Kocoglu, Jean Yared, Nancy M Hardy, Aaron P Rapoport, Djordje Atanackovic

Journal: Blood Adv

PubMed ID: 34941995

Doi: 10.1182/bloodadvances.2021006112

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A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Authors: K Y Chen, T Krischuns, L Ortega Varga, E Harigua-Souiai, S Paisant, A Zettor, J Chiaravalli, D Courtney, A O'Brien, S C Baker, C Isel, F Agou, Y Jacob, A Blondel, N Naffakh

Journal: biorxiv

PubMed ID: 34981051

Doi: 10.1101/2021.12.18.473303

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Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel G Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal N Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: Nature

PubMed ID: 35016196

Doi: 10.1038/s41586-021-04387-1

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