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Live-cell imaging of microRNA expression with post-transcriptional feedback control

Authors: Masayuki Sano, Kana Morishita, Satoshi Oikawa, Takayuki Akimoto, Kimio Sumaru, Yoshio Kato

Journal: Mol Ther Nucleic Acids

PubMed ID: 34631284

Doi: 10.1016/j.omtn.2021.08.018

Products & Services: Mammalian Expression

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin

Authors: Adriana E Galván, Ngozi P Paul, Jian Chen, Kunie Yoshinaga-Sakurai, Sagar M Utturkar, Barry P Rosen, Masafumi Yoshinaga

Journal: Microbiol Spectr

PubMed ID: 34378964

Doi: 10.1128/Spectrum.00502-21

Products & Services: Mammalian Expression

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Authors: Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu

Journal: Signal Transduct Target Ther

PubMed ID: 34408131

Doi: 10.1038/s41392-021-00726-w

Products & Services: GenParts™ DNA Fragments

Aptamer-Integrated Scaffolds for Biologically Functional DNA Origami Structures

Authors: Xiaoxing Chen, Bin Jia, Zhangwei Lu, Libing Liao, Hanyang Yu, Zhe Li

Journal: ACS Appl Mater Interfaces

PubMed ID: 34402304

Doi: 10.1021/acsami.1c09307

Products & Services: GenParts™ DNA Fragments

Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid

Authors: Jae Ho Shin, Aaron John Christian Andersen, Puck Achterberg, Lisbeth Olsson

Journal: Microb Cell Fact

PubMed ID: 34348702

Doi: 10.1186/s12934-021-01647-7

Products & Services: Gene Synthesis

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice

Authors: Arshad Khan, Ekramy E Sayedahmed, Vipul K Singh, Abhishek Mishra, Stephanie Dorta-Estremera, Sita Nookala, David H Canaday, Min Chen, Jin Wang, K Jagannadha Sastry, Suresh K Mittal, Chinnaswamy Jagannath

Journal: Cell Rep Med

PubMed ID: 34467249

Doi: 10.1016/j.xcrm.2021.100372

Products & Services: Gene Synthesis

Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from

Authors: Geunyeong Kim, Minhwa Hong, Ayesha Kashif, Yujin Hong, Beom-Seok Park, Ji-Young Mun, Hyosun Choi, Ji-Sook Lee, Eun-Ju Yang, Ran-Sook Woo, Soo-Jin Lee, Minseo Yang, In-Sik Kim

Journal: Int J Mol Sci

PubMed ID: 34445142

Doi: 10.3390/ijms22168440

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Decisive Effects of Life Stage on the Gut Microbiota Discrepancy Between Two Wild Populations of Hibernating Asiatic Toads ()

Authors: Xiaowei Song, Jingwei Zhang, Jinghan Song, Yuanyuan Zhai

Journal: Front Microbiol

PubMed ID: 34413833

Doi: 10.3389/fmicb.2021.665849

Products & Services: DNA Sequencing

Functionalizing Cell-Free Systems with CRISPR-Associated Proteins: Application to RNA-Based Circuit Engineering

Authors: François-Xavier Lehr, Alina Kuzembayeva, Megan E Bailey, Werner Kleindienst, Johannes Kabisch, Heinz Koeppl

Journal: ACS Synth Biol

PubMed ID: 34383464

Doi: 10.1021/acssynbio.0c00386

Products & Services: DNA Sequencing

Development of a real-time recombinase-aided amplification (RT-RAA) molecular diagnosis assay for sensitive and rapid detection of Toxoplasma gondii

Authors: Zhao-Hua Wang, Wei Zhang, Xiu-Zhong Zhang, Xin-Ran Yao, Wei Huang, Hong Jia, Xiao-Lei Liu, Shao-Hua Hou, Xiao-Jia Wang

Journal: Vet Parasitol

PubMed ID: 34384956

Doi: 10.1016/j.vetpar.2021.109489

Products & Services: DNA Sequencing

Engineering entropy-driven based multiple signal amplification strategy for visualized assay of miRNA by naked eye

Authors: Sha Zhu, Yi Qi Yang, Yuedi Ding, Ninghan Feng, Menglu Li, Yongmei Yin

Journal: Talanta

PubMed ID: 34517667

Doi: 10.1016/j.talanta.2021.122810

Products & Services: DNA Sequencing

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease

Authors: Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng, Huanhuan Jin

Journal: Cell Prolif

PubMed ID: 34346124

Doi: 10.1111/cpr.13107

Products & Services: DNA Sequencing

MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4

Authors: Ping Fan, Likun Zhang, Tianyu Cheng, Jing Wang, Junyun Zhou, Li Zhao, Cuie Hua, Quan Xia

Journal: J Mol Histol

PubMed ID: 34406553

Doi: 10.1007/s10735-021-10009-x

Products & Services: DNA Sequencing

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Authors: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan

Journal: Nat Commun

PubMed ID: 34404805

Doi: 10.1038/s41467-021-25331-x

Products & Services: DNA Sequencing

Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo

Authors: Shaohui Wang, Ujjaldeep Jaggi, Jack Yu, Homayon Ghiasi

Journal: PLoS Pathog

PubMed ID: 34352042

Doi: 10.1371/journal.ppat.1009848

Products & Services: DNA Sequencing

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Authors: Juliana C Ferreira, Samar Fadl, Metehan Ilter, Hanife Pekel, Rachid Rezgui, Ozge Sensoy, Wael M Rabeh

Journal: FASEB J

PubMed ID: 34324734

Doi: 10.1096/fj.202100994

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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

Authors: Serdar Durdagi, Çağdaş Dağ, Berna Dogan, Merve Yigin, Timucin Avsar, Cengizhan Buyukdag, Ismail Erol, Fatma Betul Ertem, Seyma Calis, Gunseli Yildirim, Muge D Orhan, Omur Guven, Busecan Aksoydan, Ebru Destan, Kader Sahin, Sabri O Besler, Lalehan Oktay, Alaleh Shafiei, Ilayda Tolu, Esra Ayan, Busra Yuksel, Ayse B Peksen, Oktay Gocenler, Ali D Yucel, Ozgur Can, Serena Ozabrahamyan, Alpsu Olkan, Ece Erdemoglu, Fulya Aksit, Gokhan Tanisali, Oleksandr M Yefanov, Anton Barty, Alexandra Tolstikova, Gihan K Ketawala, Sabine Botha, E Han Dao, Brandon Hayes, Mengning Liang, Matthew H Seaberg, Mark S Hunter, Alex Batyuk, Valerio Mariani, Zhen Su, Frederic Poitevin, Chun Hong Yoon, Christopher Kupitz, Raymond G Sierra, Edward H Snell, Hasan DeMirci

Journal: Structure

PubMed ID: 34403647

Doi: 10.1016/j.str.2021.07.007

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An epigenetic basis of inbreeding depression in maize

Authors: Tongwen Han, Fang Wang, Qingxin Song, Wenxue Ye, Tieshan Liu, Liming Wang, Z Jeffrey Chen

Journal: Sci Adv

PubMed ID: 34452913

Doi: 10.1126/sciadv.abg5442

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DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics

Authors: Roberto Vázquez, Francisco J Caro-León, Alberto Nakal, Susana Ruiz, Carmen Doñoro, Luis García-Fernández, Blanca Vázquez-Lasa, Julio San Román, Jesús Sanz, Pedro García, María Rosa Aguilar

Journal: Carbohydr Polym

PubMed ID: 34561005

Doi: 10.1016/j.carbpol.2021.118605

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Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

Authors: Anastasiia Sukalskaia, Monique S Straub, Dawid Deneka, Marta Sawicka, Raimund Dutzler

Journal: Nat Commun

PubMed ID: 34385445

Doi: 10.1038/s41467-021-25106-4

Products & Services: Codon Optimization

The Oxoglutarate Binding Site and Regulatory Mechanism Are Conserved in Ammonium Transporter Inhibitors GlnKs from

Authors: Marie-Caroline Müller, Tristan Wagner

Journal: Int J Mol Sci

PubMed ID: 34445335

Doi: 10.3390/ijms22168631

Products & Services: Codon Optimization

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

Authors: Pavlina Chuntova, Yafei Hou, Ryosuke Naka, Akane Yamamichi, Tiffany Chen, Yitzhar Goretsky, Ryusuke Hatae, Takahide Nejo, Gary Kohanbash, Abigail L Mende, Megan Montoya, Kira M Downey, David Diebold, Jayne Skinner, Hong-Erh Liang, Bjoern Schwer, Hideho Okada

Journal: Neuro Oncol

PubMed ID: 34347086

Doi: 10.1093/neuonc/noab182

Products & Services: Codon Optimization

RGD-pectin microfiber patches for guiding muscle tissue regeneration

Authors: Chiara Emma Campiglio, Anna Carcano, Lorenza Draghi

Journal: J Biomed Mater Res A

PubMed ID: 34423891

Doi: 10.1002/jbm.a.37301

Products & Services: Catalog Peptides

Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma

Authors: Yue A Qi, Tapan K Maity, Constance M Cultraro, Vikram Misra, Xu Zhang, Catherine Ade, Shaojian Gao, David Milewski, Khoa D Nguyen, Mohammad H Ebrahimabadi, Ken-Ichi Hanada, Javed Khan, Cenk Sahinalp, James C Yang, Udayan Guha

Journal: Mol Cell Proteomics

PubMed ID: 34391887

Doi: 10.1016/j.mcpro.2021.100136

Products & Services: Catalog Peptides

ELMO1 signaling is a promoter of osteoclast function and bone loss

Authors: Sanja Arandjelovic, Justin S A Perry, Ming Zhou, Adam Ceroi, Igor Smirnov, Scott F Walk, Laura S Shankman, Isabelle Cambré, Suna Onengut-Gumuscu, Dirk Elewaut, Thomas P Conrads, Kodi S Ravichandran

Journal: Nat Commun

PubMed ID: 34404802

Doi: 10.1038/s41467-021-25239-6

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UbiD domain dynamics underpins aromatic decarboxylation

Authors: Stephen A Marshall, Karl A P Payne, Karl Fisher, Gabriel R Titchiner, Colin Levy, Sam Hay, David Leys

Journal: Nat Commun

PubMed ID: 34417452

Doi: 10.1038/s41467-021-25278-z

Products & Services: Catalog Antibody

BioParts-A Biological Parts Search Portal and Updates to the ICE Parts Registry Software Platform

Authors: Hector A Plahar, Thomas N Rich, Stephen D Lane, William C Morrell, Leanne Springthorpe, Oge Nnadi, Elena Aravina, Tiffany Dai, Michael J Fero, Nathan J Hillson, Christopher J Petzold

Journal: ACS Synth Biol

PubMed ID: 34449214

Doi: 10.1021/acssynbio.1c00263

Products & Services: Gene Synthesis

Bone developmental toxicity of organophosphorus flame retardants TDCIPP and TPhP in marine medaka Oryzias melastigma

Authors: Haizheng Hong, Yunchen Zhao, Lingming Huang, Daiyin Zhong, Dalin Shi

Journal: Ecotoxicol Environ Saf

PubMed ID: 34371453

Doi: 10.1016/j.ecoenv.2021.112605

Products & Services: Gene Synthesis

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

Authors: Chirosree Bandyopadhyay, Leslayann Schecterson, Barry M Gumbiner

Journal: Tissue barriers

PubMed ID: 34402758

Doi: 10.1080/21688370.2021.1940741

Products & Services: Custom DNA/RNA Oligos

Analysis of the Manganese and MntR Regulon in Corynebacterium diphtheriae

Authors: Eric D Peng, Lindsey R Lyman, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 34370555

Doi: 10.1128/JB.00274-21

Products & Services: Recombinant Proteins

Generation of hypoxia-sensing chimeric antigen receptor T cells

Authors: Paris Kosti, Karen I Larios-Martinez, John Maher, James N Arnold

Journal: STAR Protoc

PubMed ID: 34401788

Doi: 10.1016/j.xpro.2021.100723

Products & Services: Gene Synthesis

Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B

Authors: Zuzanna Pakosz, Ting-Yu Lin, Elizabeth Michalczyk, Soshichiro Nagano, Jonathan Gardiner Heddle

Journal: Antimicrob Agents Chemother

PubMed ID: 34339271

Doi: 10.1128/AAC.00267-21

Products & Services: Proteins, Expression, Isolation and Analysis

Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

Authors: Michelle P Aranha, Thomas A Penfound, Sanaz Salehi, Anne Botteaux, Pierre Smeesters, James B Dale, Jeremy C Smith

Journal: J Immunol

PubMed ID: 34341168

Doi: 10.4049/jimmunol.2100286

Products & Services: Gene Synthesis

Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Authors: Lauren E Williamson, Kristen M Reeder, Kevin Bailey, Minh H Tran, Vicky Roy, Mallorie E Fouch, Nurgun Kose, Andrew Trivette, Rachel S Nargi, Emma S Winkler, Arthur S Kim, Christopher Gainza, Jessica Rodriguez, Erica Armstrong, Rachel E Sutton, Joseph Reidy, Robert H Carnahan, W Hayes McDonald, Clara T Schoeder, William B Klimstra, Edgar Davidson, Benjamin J Doranz, Galit Alter, Jens Meiler, Kevin L Schey, Justin G Julander, Michael S Diamond, James E Crowe

Journal: Cell

PubMed ID: 34416147

Doi: 10.1016/j.cell.2021.07.033

Products & Services: Plasmid DNA Preparation

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage

Authors: Kamalakannan Vijayan, Ganesh Ram R Visweswaran, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L Brown, Alexander Watson, Meghan Zuck, Nicholas Dambrauskas, Andrew Raappana, Sara Carbonetti, Laurel Kelnhofer-Millevolte, Elizabeth K K Glennon, Rachel Postiglione, D Noah Sather, Alexis Kaushansky

Journal: Cell Rep

PubMed ID: 34348141

Doi: 10.1016/j.celrep.2021.109489

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iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

Authors: Danielle M Garshott, Heeseon An, Elayanambi Sundaramoorthy, Marilyn Leonard, Alison Vicary, J Wade Harper, Eric J Bennett

Journal: Cell Rep

PubMed ID: 34469731

Doi: 10.1016/j.celrep.2021.109642

Products & Services: Proteins, Expression, Isolation and Analysis

NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

Authors: Zikai Zhou, Guiqin He, Xiaoyun Zhang, Xin Lv, Xiaolin Zhang, An Liu, Shuting Xia, Hao Xie, Rui Dang, Lifang Han, Junxia Qi, Yanghong Meng, Shunying Yu, Wei Xie, Zhengping Jia

Journal: Cell Rep

PubMed ID: 34407403

Doi: 10.1016/j.celrep.2021.109515

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A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Authors: Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann

Journal: Nat Commun

PubMed ID: 34465781

Doi: 10.1038/s41467-021-25506-6

Products & Services: Bacterial Expression

Structural basis for Ca activation of the heteromeric PKD1L3/PKD2L1 channel

Authors: Qiang Su, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, Yigong Shi

Journal: Nat Commun

PubMed ID: 34381056

Doi: 10.1038/s41467-021-25216-z

Products & Services: Polyclonal Antibody Services

Systematic Genome-Wide Study and Expression Analysis of Gene Family: Sugar Transporter Family Contributes to Biotic and Abiotic Stimuli in Watermelon

Authors: Changqing Xuan, Guangpu Lan, Fengfei Si, Zhilong Zeng, Chunxia Wang, Vivek Yadav, Chunhua Wei, Xian Zhang

Journal: Int J Mol Sci

PubMed ID: 34445115

Doi: 10.3390/ijms22168407

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Extremely short bioavailability and fast pharmacodynamic effects of pMHC-based nanomedicines

Authors: Yang Yang, Kristofor K Ellestad, Santiswarup Singha, Muhammad Myn Uddin, Robert Clarke, Debajyoti Mondal, Nahir Garabatos, Patricia Solé, Cesar Fandos, Pau Serra, Pere Santamaria

Journal: J Control Release

PubMed ID: 34474072

Doi: 10.1016/j.jconrel.2021.08.043

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A resource of high-quality and versatile nanobodies for drug delivery

Authors: Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman-Duhovny, Carlos Camacho, Guillermo Calero, Baoli Hu, Yi Shi

Journal: iScience

PubMed ID: 34522857

Doi: 10.1016/j.isci.2021.103014

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Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Authors: Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana

Journal: iScience

PubMed ID: 34430803

Doi: 10.1016/j.isci.2021.103006

Products & Services: Recombinant Proteins

Functional Characterization of the Nemertide α Family of Peptide Toxins

Authors: Erik Jacobsson, Steve Peigneur, Håkan S Andersson, Quentin Laborde, Malin Strand, Jan Tytgat, Ulf Göransson

Journal: J Nat Prod

PubMed ID: 34445875

Doi: 10.1021/acs.jnatprod.1c00104

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Fast and efficient generation of a full-length balancer chromosome by a single Cre/loxP recombination event

Authors: Cunxiang Ju, Mingkun Zhang, Min Guan, Song Li, Yuxi Zhang, Jing Zhao, Xiang Gao

Journal: Mamm Genome

PubMed ID: 34386878

Doi: 10.1007/s00335-021-09897-x

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Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of gene expression by detergent-like protein domains

Authors: Bradley K Broyles, Andrew T Gutierrez, Theodore P Maris, Daniel A Coil, Thomas M Wagner, Xiao Wang, Daisuke Kihara, Caleb A Class, Alexandre M Erkine

Journal: iScience

PubMed ID: 34522860

Doi: 10.1016/j.isci.2021.103017

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Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Authors: Catarina F Almeida, Dylan G M Smith, Tan-Yun Cheng, Chris M Harpur, Elena Batleska, Catriona V Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J J Reddiex, Shihan Li, Sidonia B G Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P Uldrich, D Branch Moody, Spencer J Williams, Daniel G Pellicci, Dale I Godfrey

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34417291

Doi: 10.1073/pnas.2104420118

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SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Authors: Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Daniel Harari, Jeanne Chiaravalli, Björn Meyer, Yinon Rudich, Chunlin Li, Ira Marton, Orly Dym, Nadav Elad, Mark G Lewis, Hanne Andersen, Matthew Gagne, Robert A Seder, Daniel C Douek, Gideon Schreiber

Journal: Nat Microbiol

PubMed ID: 34400835

Doi: 10.1038/s41564-021-00954-4

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Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels

Authors: Dongfang Tang, Jiahui Xu, Yinping Li, Piao Zhao, Xiangjin Kong, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu

Journal: J Biol Chem

PubMed ID: 34391777

Doi: 10.1016/j.jbc.2021.101076

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An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

Authors: Jerod L Ptacin, Carolina E Caffaro, Lina Ma, Kristine M San Jose Gall, Hans R Aerni, Nicole V Acuff, Rob W Herman, Yelena Pavlova, Michael J Pena, David B Chen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Marcos E Milla

Journal: Nat Commun

PubMed ID: 34373459

Doi: 10.1038/s41467-021-24987-9

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Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice

Authors: Mingyuan Han, Tomoko Ishikawa, Claudia C Stroupe, Haley A Breckenridge, J Kelley Bentley, Marc B Hershenson

Journal: Mucosal Immunol

PubMed ID: 34354243

Doi: 10.1038/s41385-021-00436-0

Products & Services: Mammalian Expression

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

Authors: Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Charles Mosier, Christopher B Lietz, Gen Ito, William H Gerwick, Dennis W Wolan, Gregory Hook, Anthony J O'Donoghue, Vivian Hook

Journal: ACS Chem Biol

PubMed ID: 34416110

Doi: 10.1021/acschembio.1c00138

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Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Authors: Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui, Bin Wang

Journal: Stem Cell Res Ther

PubMed ID: 34419172

Doi: 10.1186/s13287-021-02537-w

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Proteome-Wide Profiling of Readers for DNA Modification

Authors: Lin Bai, Guojian Yang, Zhaoyu Qin, Jiacheng Lyu, Yunzhi Wang, Jinwen Feng, Mingwei Liu, Tongqing Gong, Xianju Li, Zhengyang Li, Jixi Li, Jun Qin, Wenjun Yang, Chen Ding

Journal: Adv Sci (Weinh)

PubMed ID: 34351703

Doi: 10.1002/advs.202101426

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Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes

Authors: Zhong-Qing Li, Yao Zhang, He Li, Ting-Ting Su, Cheng-Gong Liu, Zi-Chao Han, Ai-Ying Wang, Jian-Bo Zhu

Journal: Front Plant Sci

PubMed ID: 34490001

Doi: 10.3389/fpls.2021.696698

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Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene

Authors: Melanie L Bailey, David Tieu, Andrea Habsid, Amy Hin Yan Tong, Katherine Chan, Jason Moffat, Philip Hieter

Journal: Life Sci Alliance

PubMed ID: 34462321

Doi: 10.26508/lsa.202101083

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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Authors: Fei Liu, Amy C H Lee, Fang Guo, Andrew S Kondratowicz, Holly M Micolochick Steuer, Angela Miller, Lauren D Bailey, Xiaohe Wang, Shuai Chen, Steven G Kultgen, Andrea Cuconati, Andrew G Cole, Dimitar Gotchev, Bruce D Dorsey, Rene Rijnbrand, Angela M Lam, Michael J Sofia, Min Gao

Journal: J Virol

PubMed ID: 34191584

Doi: 10.1128/JVI.00574-21

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Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson's Disease

Authors: Min Chen, Li Peng, Ping Gong, Xiaoli Zheng, Tao Sun, Xiaoqiao Zhang, Jiangtao Huo

Journal: Biochem Res Int

PubMed ID: 34457363

Doi: 10.1155/2021/2319412

Products & Services: Proteins, Expression, Isolation and Analysis

COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity

Authors: Soo-Kyung Jeong, Yoon-Ki Heo, Jei-Hyun Jeong, Su-Jin Ham, Jung-Sun Yum, Byung-Cheol Ahn, Chang-Seon Song, Eun-Young Chun

Journal: Vaccines (Basel)

PubMed ID: 34579194

Doi: 10.3390/vaccines9090957

Products & Services: Proteins, Expression, Isolation and Analysis

MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A

Authors: Maayan Hemed-Shaked, Mary K Cowman, Jin Ryoun Kim, Xiayun Huang, Edward Chau, Haim Ovadia, Keren-Or Amar, Lora Eshkar-Sebban, Michal Melamed, Libat Bar Lev, Eli Kedar, Jordi Armengol, Jorge Alemany, Shaul Beyth, Eli Okon, Darja Kanduc, Sharona Elgavish, Shulamit B Wallach-Dayan, Shmuel Jaffe Cohen, David Naor

Journal: J Autoimmun

PubMed ID: 34390919

Doi: 10.1016/j.jaut.2021.102713

Products & Services: Proteins, Expression, Isolation and Analysis

Influence of Electrolyte Concentration on Single-Molecule Sensing of Perfluorocarboxylic Acids

Authors: Xinyun Yao, Ning-Ning Song, Jia Wang, Xian Zhao, Meng-Yuan Cheng, Jiaqi Zuo, Kaipei Qiu

Journal: Front Chem

PubMed ID: 34414165

Doi: 10.3389/fchem.2021.732378

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide identification of CK gene family suggests functional expression pattern against Cd stress in Gossypium hirsutum L

Authors: Jing Wang, Yuexin Zhang, Nan Xu, Hong Zhang, Yapeng Fan, Cun Rui, Mingge Han, Waqar Afzal Malik, Qinqin Wang, Liangqing Sun, Xiugui Chen, Xuke Lu, Delong Wang, Lanjie Zhao, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Wuwei Ye

Journal: Int J Biol Macromol

PubMed ID: 34364943

Doi: 10.1016/j.ijbiomac.2021.07.190

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Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients

Authors: Victoria G Hall, Victor H Ferreira, Matthew Ierullo, Terrance Ku, Tina Marinelli, Beata Majchrzak-Kita, Anila Yousuf, Vathany Kulasingam, Atul Humar, Deepali Kumar

Journal: Am J Transplant

PubMed ID: 34347934

Doi: 10.1111/ajt.16766

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mRNA Vaccines Enhance Neutralizing Immunity against SARS-CoV-2 Variants in Convalescent and ChAdOx1-Primed Subjects

Authors: Dorit Fabricius, Carolin Ludwig, Judith Scholz, Immanuel Rode, Chrysanthi Tsamadou, Eva-Maria Jacobsen, Martina Winkelmann, Aline Grempels, Ramin Lotfi, Aleš Janda, Sixten Körper, Guido Adler, Klaus-Michael Debatin, Hubert Schrezenmeier, Bernd Jahrsdörfer

Journal: Vaccines (Basel)

PubMed ID: 34452043

Doi: 10.3390/vaccines9080918

Products & Services: Recombinant Proteins

HSP70 inhibition suppressed glioma cell viability during hypoxia/reoxygenation by inhibiting the ERK1/2 and PI3K/AKT signaling pathways

Authors: Haiyan Liu, Zhi Li, Qingshu Li, Chao Jia, Nan Zhang, Yan Qu, Dan Hu

Journal: J Bioenerg Biomembr

PubMed ID: 34363569

Doi: 10.1007/s10863-021-09904-5

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Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction

Authors: Di Guo, Yi-Jie Zhang, Su Zhang, Jian Li, Chao Guo, Yu-Feng Pan, Ning Zhang, Chen-Xi Liu, Ya-Long Jia, Chen-Yu Li, Jun-Yu Ma, Dick R Nässel, Cong-Fen Gao, Shun-Fan Wu

Journal: PLoS Genet

PubMed ID: 34398892

Doi: 10.1371/journal.pgen.1009724

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Anti-contactin-1 Antibodies Affect Surface Expression and Sodium Currents in Dorsal Root Ganglia

Authors: Julia Grüner, Helena Stengel, Christian Werner, Luise Appeltshauser, Claudia Sommer, Carmen Villmann, Kathrin Doppler

Journal: Neurol Neuroimmunol Neuroinflamm

PubMed ID: 34429341

Doi: 10.1212/NXI.0000000000001056

Products & Services: Mammalian Expression

-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Authors: Cheleka A M Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D Reid, Nicole Bilek, Morten Ruhwald, Jason R Andrews, Mark Hatherill, Francesca Little, Thomas J Scriba, Elisa Nemes

Journal: Front Immunol

PubMed ID: 34526988

Doi: 10.3389/fimmu.2021.712480

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Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection

Authors: Pembe Derin Oygar, Yasemin Ozsurekci, Sibel Lacinel Gurlevik, Kubra Aykac, Musa Gurel Kukul, Burcu Ceylan Cura Yayla, Sare Ilbay, Jale Karakaya, Ozlem Teksam, Ali Bulent Cengiz, Mehmet Ceyhan

Journal: Pediatr Infect Dis J

PubMed ID: 34250968

Doi: 10.1097/INF.0000000000003199

Products & Services: Proteins, Expression, Isolation and Analysis

Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior

Authors: Ravi Das, Shatabdi Bhattacharjee, Jamin M Letcher, Jenna M Harris, Sumit Nanda, Istvan Foldi, Erin N Lottes, Hansley M Bobo, Benjamin D Grantier, József Mihály, Giorgio A Ascoli, Daniel N Cox

Journal: Development

PubMed ID: 34322714

Doi: 10.1242/dev.187609

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Synthesis of precision antibody conjugates using proximity-induced chemistry

Authors: Yu J Cao, Chenfei Yu, Kuan-Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao

Journal: Theranostics

PubMed ID: 34522229

Doi: 10.7150/thno.62444

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Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation

Authors: Caixia Liu, Benlong Cai, Dan Li, Yuan Yao

Journal: Innate Immun

PubMed ID: 34428935

Doi: 10.1177/17534259211035426

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Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease

Authors: Stéphanie Andrade, Joana Angélica Loureiro, Maria do Carmo Pereira

Journal: Arch Biochem Biophys

PubMed ID: 34461085

Doi: 10.1016/j.abb.2021.109022

Products & Services: Mammalian Expression

A novel fluorescent aptasensor based on exonuclease-assisted triple recycling amplification for sensitive and label-free detection of aflatoxin B1

Authors: Hao Wu, Hongyong Wang, Jun Wu, Guoqing Han, Yaling Liu, Pei Zou

Journal: J Hazard Mater.

PubMed ID: 33743380

Doi: 10.1016/j.jhazmat.2021.125584

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Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Authors: Yuan Jin, Qilin Meng, Bihui Zhang, Chen Xie, Xue Chen, Baoqing Tian, Jiakang Wang, Tsung-Chieh Shih, Yibo Zhang, Jieqiong Cao, Yiqi Yang, Size Chen, Xinyuan Guan, Xiaojia Chen, An Hong

Journal: Int J Biol Sci

PubMed ID: 34671193

Doi: 10.7150/ijbs.62571

Products & Services: DNA Sequencing

Helicase-AID: A novel molecular device for base editing at random genomic loci

Authors: Jie Wang, Dongdong Zhao, Ju Li, Muzi Hu, Xiuqing Xin, Marcus A Price, Qingyan Li, Li Liu, Siwei Li, Susan J Rosser, Chunzhi Zhang, Changhao Bi, Xueli Zhang

Journal: Metab Eng

PubMed ID: 34411701

Doi: 10.1016/j.ymben.2021.08.005

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Sclerotinia sclerotiorum Thioredoxin1 (SsTrx1) is required for pathogenicity and oxidative stress tolerance

Authors: Kusum Rana, Yijuan Ding, Surinder S Banga, Hongmei Liao, Siqi Zhao, Yang Yu, Wei Qian

Journal: Mol Plant Pathol

PubMed ID: 34459563

Doi: 10.1111/mpp.13127

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Expression and characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for application in enhancing fatty acids flavor release for low-fat cheeses

Authors: Junxin Zhao, Maomao Ma, Xianghui Yan, Guohua Zhang, Jiaheng Xia, Guibing Zeng, Wenran Tian, Xianliang Bao, Zheling Zeng, Ping Yu, Deming Gong

Journal: Food Chem

PubMed ID: 34438173

Doi: 10.1016/j.foodchem.2021.130868

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Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat

Authors: Elham Rezvannejad, Seyed Azim Mousavizadeh, Safa Lotfi, Najmeh Kargar

Journal: Anim Biotechnol

PubMed ID: 34370605

Doi: 10.1080/10495398.2021.1954935

Molecular Context of Dopa Influences Adhesion of Mussel-Inspired Peptides

Authors: George D Degen, Keila C Cunha, Zachary A Levine, J Herbert Waite, Joan-Emma Shea

Journal: J Phys Chem B

PubMed ID: 34459591

Doi: 10.1021/acs.jpcb.1c05218

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Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

Authors: Ning Wu, Zhi Li, Jing Wang, Lihua Geng, Yang Yue, Zhenzhen Deng, Qingchi Wang, Quanbin Zhang

Journal: Carbohydr Polym

PubMed ID: 34560978

Doi: 10.1016/j.carbpol.2021.118567

Products & Services: Recombinant Proteins

Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca levels

Authors: Ferdinand F Fatiga, Li-Jie Wang, Tian Hsu, Jenica Irish Capuno, Chi-Yu Fu

Journal: J Cell Biochem

PubMed ID: 34431132

Doi: 10.1002/jcb.30138

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Light-Responsive Dynamic Protein Hydrogels Based on LOVTRAP

Authors: Tianyu Duan, Qingyuan Bian, Hongbin Li

Journal: Langmuir

PubMed ID: 34396769

Doi: 10.1021/acs.langmuir.1c01699

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Merlin functions as a critical regulator in Staphylococcus aureus-induced osteomyelitis

Authors: Zubin Zhou, Yuanliang Chen, Hong Sung Min, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Xiaowei Yu

Journal: J Cell Physiol

PubMed ID: 34378805

Doi: 10.1002/jcp.30550

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Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution

Authors: Andreia M Silva, Elisa Lázaro-Ibáñez, Anders Gunnarsson, Aditya Dhande, George Daaboul, Ben Peacock, Xabier Osteikoetxea, Nikki Salmond, Kristina Pagh Friis, Olga Shatnyeva, Niek Dekker

Journal: J Extracell Vesicles

PubMed ID: 34377376

Doi: 10.1002/jev2.12130

Products & Services: Proteins, Expression, Isolation and Analysis

An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles

Authors: Tiffany R Frey, Ibukun A Akinyemi, Eric M Burton, Sumita Bhaduri-McIntosh, Michael T McIntosh

Journal: Front Microbiol

PubMed ID: 34434177

Doi: 10.3389/fmicb.2021.708404

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Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from

Authors: Zahra Najarzadeh, Janni Nielsen, Azad Farzadfard, Vita Sereikaite, Kristian Strømgaard, Rikke Louise Meyer, Daniel Erik Otzen

Journal: ACS Omega

PubMed ID: 34497891

Doi: 10.1021/acsomega.1c02333

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() Could Inhibit the Proliferation of Nucleopolyhedrovirus through Promoting Apoptosis

Authors: Jie Wang, Lin-Bao Zhu, Yan Ma, Ying-Xue Liu, Hui-Hua Cao, Yu-Ling Wang, Xue Kong, Zhi-Hao Huang, Han-Dan Zhu, Yan-Xiang Wang, Shi-Huo Liu, Jia-Ping Xu

Journal: Insects

PubMed ID: 34442307

Doi: 10.3390/insects12080743

Products & Services: Recombinant Antibody Expression

Coleopteran-specific StaufenC functions like Loquacious-PD in dsRNA processing

Authors: Kyungbo Kim, Jinmo Koo, June-Sun Yoon, Subba Reddy Palli

Journal: RNA Biol

PubMed ID: 34376105

Doi: 10.1080/15476286.2021.1960687

Products & Services: Recombinant Antibody Expression

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano

Journal: Arthritis Res Ther

PubMed ID: 34344444

Doi: 10.1186/s13075-021-02555-2

Products & Services: Proteins, Expression, Isolation and Analysis

Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Authors: Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Grünewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A Slattery, Jakob von Engelhardt, Michael J Courtney, Andreas Reif

Journal: EBioMedicine

PubMed ID: 34455393

Doi: 10.1016/j.ebiom.2021.103565

Products & Services: Proteins, Expression, Isolation and Analysis

Refining the N-Termini of the SARS-CoV-2 Spike Protein and Its Discrete Receptor-Binding Domain

Authors: Robert A D'Ippolito, Matthew R Drew, Jennifer Mehalko, Kelly Snead, Vanessa Wall, Zoe Putman, Dominic Esposito, Caroline J DeHart

Journal: J Proteome Res

PubMed ID: 34379411

Doi: 10.1021/acs.jproteome.1c00349

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

Authors: Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar

Journal: Nat Struct Mol Biol

PubMed ID: 34373645

Doi: 10.1038/s41594-021-00635-0

Products & Services: Proteins, Expression, Isolation and Analysis

Tandem Mass Spectrometry as Strategy for the Selective Identification and Quantification of the Amyloid Precursor Protein Tyr682 Residue Phosphorylation Status in Human Blood Mononuclear Cells

Authors: Pierluigi Reveglia, Rosarita Nasso, Antonella Angiolillo, Lucia Lecce, Carmela Paolillo, Samantha De Tullio, Monica Gelzo, Alfonso Di Costanzo, Carmela Matrone, Gaetano Corso

Journal: Biomolecules

PubMed ID: 34572510

Doi: 10.3390/biom11091297

Products & Services: Peptide Synthesis

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

Authors: Shailesh K Shahi, Soham Ali, Camille M Jaime, Natalya V Guseva, Ashutosh K Mangalam

Journal: Immunohorizons

PubMed ID: 34380664

Doi: 10.4049/immunohorizons.2100024

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CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

Authors: Sarah A Greaves, Avinash Ravindran, Radleigh G Santos, Lan Chen, Michael T Falta, Yang Wang, Angela M Mitchell, Shaikh M Atif, Douglas G Mack, Alex N Tinega, Lisa A Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P Fontenot

Journal: J Exp Med

PubMed ID: 34410304

Doi: 10.1084/jem.20210785

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Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families

Authors: Alfonso Méndez-Godoy, Daniel García-Montalvo, León P Martínez-Castilla, Nuria Sánchez-Puig

Journal: Mol Genet Genomics

PubMed ID: 34453201

Doi: 10.1007/s00438-021-01814-w

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New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

Authors: Toni Rendulić, João Alves, João Azevedo-Silva, Isabel Soares-Silva, Margarida Casal

Journal: Comput Struct Biotechnol J

PubMed ID: 34471488

Doi: 10.1016/j.csbj.2021.08.002

Products & Services: ORF cDNA Clones/MolecularCloud

Double-Stranded RNA-Degrading Enzymes Reduce the Efficiency of RNA Interference in

Authors: Jin-Zhi Chen, Ying-Xia Jiang, Miao-Wen Li, Jian-Wen Li, Ben-Hu Zha, Guang Yang

Journal: Insects

PubMed ID: 34442278

Doi: 10.3390/insects12080712

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