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LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3

Authors: Jing Li, Xiaojie Quan, Saifei Lei, Gang Chen, Jiawei Hong, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang

Journal: Environ Pollut

PubMed ID: 34801623

Doi: 10.1016/j.envpol.2021.118542

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Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine suicide system for canine melanoma

Authors: Gerardo C Glikin, Jesica B Allende, Liliana M E Finocchiaro

Journal: Vet Comp Oncol

PubMed ID: 34724324

Doi: 10.1111/vco.12780

Products & Services: PCR Cloning and Subcloning

Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit

Authors: Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere, Lennart Martens, Sven Degroeve, Wim De Neve, Wim Vranken, Nico Callewaert

Journal: Nat Commun

PubMed ID: 34741024

Doi: 10.1038/s41467-021-26720-y

Products & Services: PCR Cloning and Subcloning

The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function

Authors: Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T Burgess, Mark N Adams, Kenneth J O'Byrne, Derek J Richard, Neha S Gandhi, Emma Bolderson

Journal: Front Cell Dev Biol

PubMed ID: 34820387

Doi: 10.3389/fcell.2021.775441

Products & Services: PCR Cloning and Subcloning

Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system

Authors: Federico Camicia, Hugo R Vaca, Sang-Kyu Park, Augusto E Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M Celentano, Jonathan S Marchant, Mara C Rosenzvit

Journal: PLoS ONE

PubMed ID: 34762657

Doi: 10.1371/journal.pone.0259104

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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel-Hagen, Christopher S Seet, Gay M Crooks, Sarah M Larson, Joshua P Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B Kohn, Owen Witte, Pin Wang, Lili Yang

Journal: Cell Rep Med

PubMed ID: 34841295

Doi: 10.1016/j.xcrm.2021.100449

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G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D receptor desensitization

Authors: Richard Ågren, Kristoffer Sahlholm

Journal: FASEB J

PubMed ID: 34699610

Doi: 10.1096/fj.202100704RR

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MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3

Authors: Xiaochen Hu, Hongjun Miao

Journal: Mol Biol Rep

PubMed ID: 34757596

Doi: 10.1007/s11033-021-06849-1

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Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances

Authors: Madison M Mann, James D Tang, Bryan W Berger

Journal: Biotechnol Bioeng

PubMed ID: 34723386

Doi: 10.1002/bit.27981

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Authors: Jasmine George, Yongsheng Li, Ishaque P Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S Rader, Anil K Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan

Journal: Cell Rep

PubMed ID: 34731628

Doi: 10.1016/j.celrep.2021.109934

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G3BP1 inhibits Cul3 to amplify AR signaling and promote prostate cancer

Authors: Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian D Robinson, Arul M Chinnaiyan, Mark A Rubin, Christopher E Barbieri, Pengbo Zhou

Journal: Nat Commun

PubMed ID: 34795264

Doi: 10.1038/s41467-021-27024-x

The B-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine

Authors: William G Walls, James D Moody, Elizabeth C McDaniel, Maria Villanueva, Eric M Shepard, William E Broderick, Joan B Broderick

Journal: J Inorg Biochem

PubMed ID: 34847521

Doi: 10.1016/j.jinorgbio.2021.111662

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Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation

Authors: Marek Jindra, William J McKinstry, Thomas Nebl, Lenka Bittova, Bin Ren, Jan Shaw, Tram Phan, Louis Lu, Jason K K Low, Joel P Mackay, Lindsay G Sparrow, George O Lovrecz, Ronald J Hill

Journal: J Biol Chem

PubMed ID: 34758356

Doi: 10.1016/j.jbc.2021.101387

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New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products

Authors: Julia K Lewis, Andrew S Jochimsen, Sarah J Lefave, Anthony P Young, William M Kincannon, Andrew G Roberts, Matthew T Kieber-Emmons, Vahe Bandarian

Journal: Biochemistry

PubMed ID: 34730336

Doi: 10.1021/acs.biochem.1c00469

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In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum

Authors: Luis Ariel Espinosa, Yassel Ramos, Ivan Andújar, Enso Onill Torres, Gleysin Cabrera, Alejandro Martín, Diamilé Roche, Glay Chinea, Mónica Becquet, Isabel González, Camila Canaán-Haden, Elías Nelson, Gertrudis Rojas, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Tamy Boggiano, Julio Palacio, Sum Lai Lozada Chang, Lourdes Hernández, Kathya Rashida de la Luz Hernández, Saloheimo Markku, Marika Vitikainen, Yury Valdés-Balbín, Darielys Santana-Medero, Daniel G Rivera, Vicente Vérez-Bencomo, Mark Emalfarb, Ronen Tchelet, Gerardo Guillén, Miladys Limonta, Eulogio Pimentel, Marta Ayala, Vladimir Besada, Luis Javier González

Journal: Anal Bioanal Chem

PubMed ID: 34739558

Doi: 10.1007/s00216-021-03721-w

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Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

Authors: Bassel Akache, Tyler M Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A Harrison, Diana Duque, Julie Haukenfrers, Martin A Rossotti, Francis Gaudreault, Usha D Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J McCluskie

Journal: Sci Rep

PubMed ID: 34750472

Doi: 10.1038/s41598-021-01363-7

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Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations

Authors: Barbora Novotná, Lucie Holá, Monika Staś, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zdeněk Vavřina, Miloš Buděšínský, Radek Liboska, Florian Chevrier, Juraj Dobiaš, Evzen Boura, Lubomír Rulíšek, Gabriel Birkuš

Journal: Biochemistry

PubMed ID: 34788017

Doi: 10.1021/acs.biochem.1c00692

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Two C1-oxidizing AA9 lytic polysaccharide monooxygenases from Sordaria brevicollis differ in thermostability, activity, and synergy with cellulase

Authors: Xi Zhang, Kaixiang Chen, Liangkun Long, Shaojun Ding

Journal: Appl Microbiol Biotechnol

PubMed ID: 34748039

Doi: 10.1007/s00253-021-11677-1

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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Authors: Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S Toor, Sarvind Tripathi, Son Nguyen, Helena Shen, Tiffany Noel, Nicole L Church, Amber Weiner, Nathan Kendsersky, Dan Martinez, Rebecca Weisberg, Molly Christie, Laurence Eisenlohr, Kristopher R Bosse, Dimiter S Dimitrov, Stefan Stevanovic, Nikolaos G Sgourakis, Ben R Kiefel, John M Maris

Journal: Nature

PubMed ID: 34732890

Doi: 10.1038/s41586-021-04061-6

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Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate and Staphylococcal Skin Infection

Authors: Sirikwan Sangboonruang, Natthawat Semakul, Mohammad A Obeid, Marta Ruano, Kuntida Kitidee, Usanee Anukool, Kidsadagon Pringproa, Panuwan Chantawannakul, Valerie A Ferro, Yingmanee Tragoolpua, Khajornsak Tragoolpua

Journal: Int J Nanomedicine

PubMed ID: 34819727

Doi: 10.2147/IJN.S325901

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Multifunctional Dendronized Polypeptides for Controlled Adjuvanticity

Authors: Zhiyuan Fan, Sharon Jan, James C Hickey, D Huw Davies, Jiin Felgner, Philip L Felgner, Zhibin Guan

Journal: Biomacromolecules

PubMed ID: 34788023

Doi: 10.1021/acs.biomac.1c01052

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Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Authors: Hojae Lee, Jae Jin Lee, Na Young Park, Sandeep Kumar Dubey, Taeyong Kim, Kai Ruan, Su Bin Lim, Seong-Hyun Park, Shinwon Ha, Irina Kovlyagina, Kyung-Tai Kim, Seongjun Kim, Yohan Oh, Hyesoo Kim, Sung-Ung Kang, Mi-Ryoung Song, Thomas E Lloyd, Nicholas J Maragakis, Young Bin Hong, Hyungjin Eoh, Gabsang Lee

Journal: Nat Neurosci

PubMed ID: 34782793

Doi: 10.1038/s41593-021-00944-z

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SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

Authors: Kisoo Pahk, Sang Gil Lee, Chanmin Joung, Eun-Ok Kim, Hyun Woo Kwon, Dong Hwi Kim, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim

Journal: Biomed Pharmacother

PubMed ID: 34813997

Doi: 10.1016/j.biopha.2021.112441

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Insights into ROS-dependent signalling underlying transcriptomic plant responses to the herbicide 2,4-D

Authors: María C Romero-Puertas, M Ángeles Peláez-Vico, Diana M Pazmiño, María Rodríguez-Serrano, Laura Terrón-Camero, Rocío Bautista, Aurelio Gómez-Cadenas, M Gonzalo Claros, José León, Luisa M Sandalio

Journal: Plant Cell Environ

PubMed ID: 34800292

Doi: 10.1111/pce.14229

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The effects of Omarigliptin on promoting osteoblastic differentiation

Authors: Fake Liao, Xiunian Hu, Rijiang Chen

Journal: Bioengineered

PubMed ID: 34787070

Doi: 10.1080/21655979.2021.1999366

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An oral vaccine based on chitosan/aluminum adjuvant induces both local and systemic immune responses in turbot (Scophthalmus maximus)

Authors: Peng Jin, Fei Sun, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiaohong Liu

Journal: Vaccine

PubMed ID: 34844823

Doi: 10.1016/j.vaccine.2021.10.063

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Production, purification and characterization of a double-tagged TEV protease

Authors: Joaquín Dalla Rizza, Claudia Ortega, Federico Carrión, Martín Fló, Agustín Correa

Journal: Protein Expr Purif

PubMed ID: 34798273

Doi: 10.1016/j.pep.2021.106021

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Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARS

Authors: Lili Zhao, Na Han, Yali Zheng, Huiying Rao, Jia Li, Yanwen Chen, Bing Yu, Yu Xu, Hongsong Chen, Zhancheng Gao, Baoguo Jiang

Journal: Front Cell Infect Microbiol

PubMed ID: 34869070

Doi: 10.3389/fcimb.2021.768993

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A binary effector module secreted by a type VI secretion system

Authors: Yasmin Dar, Biswanath Jana, Eran Bosis, Dor Salomon

Journal: EMBO Rep

PubMed ID: 34752000

Doi: 10.15252/embr.202153981

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High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein

Authors: Ching-Ting Wang, Tetsushi Tezuka, Naoki Takeda, Kimi Araki, Satoko Arai, Toru Miyazaki

Journal: PLoS ONE

PubMed ID: 34843572

Doi: 10.1371/journal.pone.0260449

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Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

Authors: Christian Tüting, Fotis L Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian, Panagiotis L Kastritis

Journal: Nat Commun

PubMed ID: 34836937

Doi: 10.1038/s41467-021-27287-4

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A Novel Serum tsRNA for Diagnosis and Prediction of Nephritis in SLE

Authors: Ping Yang, Xiaoshan Zhang, Shanshan Chen, Yue Tao, Mingzhe Ning, Yijia Zhu, Jun Liang, Wei Kong, Bo Shi, Zhiyang Li, Han Shen, Yanbo Wang

Journal: Front Immunol

PubMed ID: 34867955

Doi: 10.3389/fimmu.2021.735105

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A novel chimeric protein with enhanced cytotoxic effects on breast cancer in vitro and in vivo

Authors: Fereshte Hazrati, Massoud Saidijam, Yaghoub Ahmadyousefi, Fatemeh Nouri, Hamidreza Ghadimipour, Mohammadreza Moradi, Rasool Haddadi, Meysam Soleimani

Journal: Proteins

PubMed ID: 34812523

Doi: 10.1002/prot.26285

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Diagnostic Performance of Self-Collected Saliva Versus Nasopharyngeal Swab for the Molecular Detection of SARS-CoV-2 in the Clinical Setting

Authors: Mohammad Khaja Mafij Uddin, Tahmina Shirin, Mohammad Enayet Hossain, Ahmed Nawsher Alam, Jenifar Quaiyum Ami, Rashedul Hasan, Mojnu Miah, Nusrat Jahan Shaly, Shahriar Ahmed, S M Mazidur Rahman, Mustafizur Rahman, Sayera Banu

Journal: Microbiol Spectr

PubMed ID: 34730436

Doi: 10.1128/Spectrum.00468-21

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Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species

Authors: Xinchen Jiang, Junliang Yin, Lixin Wang, Keyong Xi, Xiongmeng Zhu, Gang Li, Yongxing Zhu, Yiqing Liu

Journal: Plant Genome

PubMed ID: 34741493

Doi: 10.1002/tpg2.20167

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Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

Authors: Andrea Moreno, Victor Taleb, María Sebastián, Ernesto Anoz-Carbonell, Marta Martínez-Júlvez, Milagros Medina

Journal: IUBMB Life

PubMed ID: 34813144

Doi: 10.1002/iub.2576

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A feminizing switch in a hemimetabolous insect

Authors: Ji-Chong Zhuo , Hou-Hong Zhang , Qing-Ling Hu , Jin-Li Zhang , Jia-Bao Lu , Han-Jing Li , Yu-Cheng Xie , Wei-Wei Wang , Yan Zhang , Hai-Qiang Wang , Hai-Jian Huang , Gang Lu , Jian-Ping Chen , Jun-Min Li , Zhi-Jian Tu , Chuan-Xi Zhang

Journal: Sci Adv

PubMed ID: 34826246

Doi: 10.1126/sciadv.abf9237

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An Efficient Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Protein 9 Mutagenesis System for Oil Palm ()

Authors: Wan-Chin Yeap, Muhammad Rashdan Muad, David Ross Appleton

Journal: Front Plant Sci

PubMed ID: 34880893

Doi: 10.3389/fpls.2021.773656

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Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

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Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

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Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells

Authors: Ana Stojiljković, Véronique Gaschen, Franck Forterre, Ulrich Rytz, Michael H Stoffel, Jasmin Bluteau

Journal: Geroscience

PubMed ID: 34806133

Doi: 10.1007/s11357-021-00488-x

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Comprehensive Comparative Analysis of the GATA Transcription Factors in Four Rosaceae Species and Phytohormonal Response in Chinese Pear () Fruit

Authors: Muhammad Aamir Manzoor, Irfan Ali Sabir, Iftikhar Hussain Shah, Han Wang, Zhao Yu, Faiz Rasool, Muhammad Zaid Mazhar, Shoaib Younas, Muhammad Abdullah, Yongping Cai

Journal: Int J Mol Sci

PubMed ID: 34830372

Doi: 10.3390/ijms222212492

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Hsa_circRNA_103124 Upregulation in Crohn's Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway

Authors: Juan Yin, Fuyi Tong, Yulan Ye, Tong Hu, Lijuan Xu, Liping Zhang, Jianyun Zhu, Zhi Pang

Journal: Front Genet

PubMed ID: 34804121

Doi: 10.3389/fgene.2021.753161

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An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function

Authors: Yuanyong Huang, Xiaoya Duan, Zhen Wang, Yimei Sun, Qingqing Guan, Li Kang, Qiao Zhang, Lan Fang, Jiwen Li, Jiemin Wong

Journal: J Biol Chem

PubMed ID: 34762910

Doi: 10.1016/j.jbc.2021.101389

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His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation

Authors: Gabrielle Parkinson, Peristera Roboti, Ling Zhang, Sandra Taylor, Philip Woodman

Journal: J Cell Sci

PubMed ID: 34657963

Doi: 10.1242/jcs.259192

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Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration and angiogenesis of keratinocytes by modulating heparanase stability

Authors: Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang

Journal: Bioengineered

PubMed ID: 34753397

Doi: 10.1080/21655979.2021.2002495

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Serine palmitoyltransferase assembles at ER-mitochondria contact sites

Authors: Mari J Aaltonen, Irina Alecu, Tim König, Steffany Al Bennett, Eric A Shoubridge

Journal: Life Sci Alliance

PubMed ID: 34785538

Doi: 10.26508/lsa.202101278

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Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Authors: Pim J Huis In 't Veld, Sabine Wohlgemuth, Carolin Koerner, Franziska Müller, Petra Janning, Andrea Musacchio

Journal: Protein Sci

PubMed ID: 34791727

Doi: 10.1002/pro.4233

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SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets

Authors: Syam Prakash Somasekharan, Martin Gleave

Journal: FEBS Lett

PubMed ID: 34780058

Doi: 10.1002/1873-3468.14229

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Antiseptic 9-Meric Peptide with Potency against Carbapenem-Resistant Infection

Authors: Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Young Kyung Yoon, Yangmee Kim

Journal: Int J Mol Sci

PubMed ID: 34830401

Doi: 10.3390/ijms222212520

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Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set

Authors: Peter Hayes, Natalia Fernandez, Christina Ochsenbauer, Jama Dalel, Jonathan Hare, Deborah King, Lucas Black, Claire Streatfield, Vanaja Kakarla, Gladys Macharia, Julia Makinde, Matt Price, Eric Hunter, Jill Gilmour

Journal: PLoS ONE

PubMed ID: 34788349

Doi: 10.1371/journal.pone.0260118

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PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Authors: Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito

Journal: Commun Biol

PubMed ID: 34764413

Doi: 10.1038/s42003-021-02801-y

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Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression

Authors: Yuhua He, Shuifang Xu, Yi Qi, Jinfang Tian, Fengying Xu

Journal: J Ovarian Res

PubMed ID: 34789312

Doi: 10.1186/s13048-021-00906-w

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Comparison of Antibody Response Elicited by ChAdOx1 and BNT162b2 COVID-19 Vaccine

Authors: Yu Min Kang, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Dong Ho Jo, Kang-Won Choe, Moon Jung Kim, Jong Min Kim, Kwang Nam Kim

Journal: J Korean Med Sci

PubMed ID: 34845875

Doi: 10.3346/jkms.2021.36.e311

Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus

Authors: Suyeon Hong, Shaobo Ruan, Zachary Greenberg, Mei He, Jodi L McGill

Journal: Sci Rep

PubMed ID: 34725399

Doi: 10.1038/s41598-021-00765-x

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CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Authors: Lorna M Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F Burrows, Ian G Mills, Emma Evergren

Journal: Cell Death Dis

PubMed ID: 34725334

Doi: 10.1038/s41419-021-04335-x

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Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea

Authors: Yu Kyung Kim, Dohsik Minn, Do Young Song, Chae Hoon Lee, Nam Hee Ryoo, Chang-Ho Jeon, Kyung Eun Song, Jang Soo Suh, Soon Hee Chang

Journal: J Korean Med Sci

PubMed ID: 34751011

Doi: 10.3346/jkms.2021.36.e294

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1

Authors: Ruing Zhao, Wei Yin, Qingqing Yu, Yanjiao Mao, Qinghua Deng, Ke Zhang, Shenglin Ma

Journal: Bioengineered

PubMed ID: 34738874

Doi: 10.1080/21655979.2021.2001238

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Performance Evaluation of the BZ COVID-19 Neutralizing Antibody Test for the Culture-Free and Rapid Detection of SARS-CoV-2 Neutralizing Antibodies

Authors: Bo Kyeung Jung, Jung Yoon, Joon-Yong Bae, Jeonghun Kim, Man-Seong Park, Suk Yong Lee, Chae Seung Lim

Journal: Diagnostics (Basel)

PubMed ID: 34943430

Doi: 10.3390/diagnostics11122193

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Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

Authors: Haiyan Hong, Zilong Guo, Hao Sun , Ping Yu , Huanhuan Su , Xuening Ma & Hu Chen

Journal: Communications Chemistry

Doi: doi.org/10.1038/s42004-021-00592-1

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Fecal microbiota changes in NZB/W F1 mice after induction of lupus disease

Authors: Yen-Fu Chen, Ao-Ho Hsieh, Lian-Chin Wang, Yun-Ju Huang, Wen-Yi Tseng, Yu-Lun Kuo, Shue-Fen Luo, Kuang-Hui Yu, Chang-Fu Kuo

Journal: Sci Rep

PubMed ID: 34824318

Doi: 10.1038/s41598-021-02422-9

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Limited Impact of Delta Variant's Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: Viruses

PubMed ID: 34960674

Doi: 10.3390/v13122405

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Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Authors: Christian Kretzer, Paul M Jordan, Katharina P L Meyer, Daniel Hoff, Markus Werner, Robert Klaus Hofstetter, Andreas Koeberle, Antonio Cala Peralta, Guillaume Viault, Denis Seraphin, Pascal Richomme, Jean-Jacques Helesbeux, Hermann Stuppner, Veronika Temml, Daniela Schuster, Oliver Werz

Journal: Biochem Pharmacol

PubMed ID: 34762841

Doi: 10.1016/j.bcp.2021.114825

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Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria

Authors: Christopher J Herbert, Sylvie Labarre-Mariotte, David Cornu, Cyrielle Sophie, Cristina Panozzo, Thomas Michel, Geneviève Dujardin, Nathalie Bonnefoy

Journal: Nucleic Acids Res

PubMed ID: 34634819

Doi: 10.1093/nar/gkab789

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ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Authors: Fei Teng, Roser Tachó-Piñot, Biin Sung, Donna L Farber, Stefan Worgall, Hamida Hammad, Bart N Lambrecht, Matthew R Hepworth, Gregory F Sonnenberg

Journal: Cell Rep

PubMed ID: 34818549

Doi: 10.1016/j.celrep.2021.110051

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Unveiling mRNP composition by fluorescence correlation and cross-correlation spectroscopy using cell lysates

Authors: Àngels Mateu-Regué, Jan Christiansen, Frederik Otzen Bagger, Christian Hellriegel, Finn Cilius Nielsen

Journal: Nucleic Acids Res

PubMed ID: 34478550

Doi: 10.1093/nar/gkab751

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TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9

Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao

Journal: iScience

PubMed ID: 34877491

Doi: 10.1016/j.isci.2021.103425

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A nanocompartment system contributes to defense against oxidative stress in

Authors: Katie A Lien, Kayla Dinshaw, Robert J Nichols, Caleb Cassidy-Amstutz, Matthew Knight, Rahul Singh, Lindsay D Eltis, David F Savage, Sarah A Stanley

Journal: Elife

PubMed ID: 34751132

Doi: 10.7554/eLife.74358

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Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases

Authors: Mariam Bakshi, Wenbin Tuo, Raffi V Aroian, Dante Zarlenga

Journal: Parasit Vectors

PubMed ID: 34798906

Doi: 10.1186/s13071-021-05010-y

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Gain of Spontaneous Mutations Boosting Motility Adaption to Environments in

Authors: Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Journal: Front Bioeng Biotechnol

PubMed ID: 34900963

Doi: 10.3389/fbioe.2021.772397

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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Authors: Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

Journal: Aging (Albany NY)

PubMed ID: 34739394

Doi: 10.18632/aging.203662

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Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression

Authors: Jianing Wang, Xiaoying Qin, Hao Sun, Meijun He, Qunyu Lv, Congcong Gao, Xinran He, Hong Liao

Journal: Aging Cell

PubMed ID: 34821024

Doi: 10.1111/acel.13515

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Spike residue 403 affects binding of coronavirus spikes to human ACE2

Authors: Fabian Zech, Daniel Schniertshauer, Christoph Jung, Alexandra Herrmann, Arne Cordsmeier, Qinya Xie, Rayhane Nchioua, Caterina Prelli Bozzo, Meta Volcic, Lennart Koepke, Janis A Müller, Jana Krüger, Sandra Heller, Steffen Stenger, Markus Hoffmann, Stefan Pöhlmann, Alexander Kleger, Timo Jacob, Karl-Klaus Conzelmann, Armin Ensser, Konstantin M J Sparrer, Frank Kirchhoff

Journal: Nat Commun

PubMed ID: 34824253

Doi: 10.1038/s41467-021-27180-0

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G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Authors: Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck

Journal: Nat Commun

PubMed ID: 34815397

Doi: 10.1038/s41467-021-26882-9

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Plant LHC-like proteins show robust folding and static non-photochemical quenching

Authors: Petra Skotnicová, Hristina Staleva-Musto, Valentyna Kuznetsova, David Bína, Minna M Konert, Shan Lu, Tomáš Polívka, Roman Sobotka

Journal: Nat Commun

PubMed ID: 34824207

Doi: 10.1038/s41467-021-27155-1

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Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization

Authors: Adeline E Williams, Gaurav Shrivastava, Apostolos G Gittis, Sundar Ganesan, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Ken E Olson, Eric Calvo

Journal: Int J Mol Sci

PubMed ID: 34884537

Doi: 10.3390/ijms222312733

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SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II

Authors: Richard King, Zesen Lin, Ginette Balbin-Cuesta, Gregg Myers, Ann Friedman, Guojing Zhu, Beth McGee, Thomas L Saunders, Ryo Kurita, Yukio Nakamura, James Douglas Engel, Pavan Reddy, Rami Khoriaty

Journal: Sci Adv

PubMed ID: 34818036

Doi: 10.1126/sciadv.abj5293

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Interaction of Copper Trafficking Proteins with the Platinum Anticancer Drug Kiteplatin

Authors: Alessandra Barbanente, Angela Galliani, Rosa Maria Iacobazzi, Alessia Lasorsa, Maria Incoronata Nardella, Antonio Pennetta, Nicola Margiotta, Fabio Arnesano

Journal: ChemMedChem

PubMed ID: 34727402

Doi: 10.1002/cmdc.202100593

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Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection

Authors: Heni Muflihah, Manuela Flórido, Leon C W Lin, Yingju Xia, James A Triccas, John Stambas, Warwick J Britton

Journal: PLoS ONE

PubMed ID: 34793507

Doi: 10.1371/journal.pone.0259829

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Improved Sensitivity of Allergen Detection by Immunoaffinity LC-MS/MS Using Ovalbumin as a Case Study

Authors: Martin Röder, Claudia Wiacek, Frauke Lankamp, Jonathan Kreyer, Wolfgang Weber, Elke Ueberham

Journal: Foods

PubMed ID: 34945483

Doi: 10.3390/foods10122932

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PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

Authors: Fengxiang Wang, Emily T Graham, Nathchar Naowarojna, Zhennan Shi, Yuqi Wang, Guanglei Xie, Lili Zhou, Wendy Salmon, Jie-Min Jia, Xi Wang, Yuwei Huang, Stuart L Schreiber, Yilong Zou

Journal: Cell Chem Biol

PubMed ID: 34813762

Doi: 10.1016/j.chembiol.2021.11.001

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Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

Authors: Xuankang Wang, Xin Li, Xiaoshuang Zuo, Zhuowen Liang, Tan Ding, Kun Li, Yangguang Ma, Penghui Li, Zhijie Zhu, Cheng Ju, Zhihao Zhang, Zhiwen Song, Huilin Quan, Jiawei Zhang, Xueyu Hu, Zhe Wang

Journal: J Neuroinflammation

PubMed ID: 34740378

Doi: 10.1186/s12974-021-02312-x

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3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels

Authors: Niraimathi Govindasamy, Hongyan Long, Hyun-Woo Jeong, Ratish Raman, Burak Özcifci, Simone Probst, Sebastian J Arnold, Kristina Riehemann, Adrian Ranga, Ralf H Adams, Britta Trappmann, Ivan Bedzhov

Journal: Dev Cell

PubMed ID: 34741805

Doi: 10.1016/j.devcel.2021.10.014

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Capillary electrophoresis-based functional genomics screening to discover novel archaeal DNA modifying enzymes

Authors: Kelly M Zatopek, Samantha L Fossa, Katharina Bilotti, Paul J Caffrey, Léa Chuzel, Alexandra M Gehring, Gregory J S Lohman, Christopher H Taron, Andrew F Gardner

Journal: Appl Environ Microbiol

PubMed ID: 34788065

Doi: 10.1128/AEM.02137-21

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New highly antigenic linear B cell epitope peptides from PvAMA-1 as potential vaccine candidates

Authors: Raianna F Fantin, Vanessa G Fraga, Camila A Lopes, Isabella C de Azevedo, João L Reis-Cunha, Dhelio B Pereira, Francisco P Lobo, Marcela M de Oliveira, Anderson C Dos Santos, Daniela C Bartholomeu, Ricardo T Fujiwara, Lilian L Bueno

Journal: PLoS ONE

PubMed ID: 34727117

Doi: 10.1371/journal.pone.0258637

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The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

Authors: Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K Simanshu, Jairaj K Acharya, Douglas R Lowy

Journal: Mol Cancer

PubMed ID: 34727930

Doi: 10.1186/s12943-021-01439-y

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The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses

Authors: David M Picton, Yvette A Luyten, Richard D Morgan, Andrew Nelson, Darren L Smith, David T F Dryden, Jay C D Hinton, Tim R Blower

Journal: Nucleic Acids Res

PubMed ID: 34657954

Doi: 10.1093/nar/gkab906

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Effector-mediated membrane disruption controls cell death in CBASS antiphage defense

Authors: Brianna Duncan-Lowey, Nora K McNamara-Bordewick, Nitzan Tal, Rotem Sorek, Philip J Kranzusch

Journal: Mol Cell

PubMed ID: 34784509

Doi: 10.1016/j.molcel.2021.10.020

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Stress Induced Transcription Factors Transactivate the Herpes Simplex Virus 1 Infected Cell Protein 27 (ICP27) Transcriptional Enhancer

Authors: Jeffery B Ostler, Clinton Jones

Journal: Viruses

PubMed ID: 34835102

Doi: 10.3390/v13112296

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A mosquito AgTRIO monoclonal antibody reduces early infection of mice

Authors: Yu-Min Chuang, Xu-Dong Tang, Erol Fikrig

Journal: Infect Immun

PubMed ID: 34724388

Doi: 10.1128/IAI.00359-21

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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Authors: Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola

Journal: Nat Commun

PubMed ID: 34795280

Doi: 10.1038/s41467-021-27075-0

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Structures of prokaryotic ubiquitin-like protein Pup in complex with depupylase Dop reveal the mechanism of catalytic phosphate formation

Authors: Hengjun Cui, Andreas U Müller, Marc Leibundgut, Jiawen Tian, Nenad Ban, Eilika Weber-Ban

Journal: Nat Commun

PubMed ID: 34789727

Doi: 10.1038/s41467-021-26848-x

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Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan

Authors: Yang Ai, Ben Wang, Shuai Xiao, Sang Luo, Yefu Wang

Journal: Int J Mol Sci

PubMed ID: 34830310

Doi: 10.3390/ijms222212428

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Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

Authors: Wooseob Kim, Julian Q Zhou, Alexandria J Sturtz, Stephen C Horvath, Aaron J Schmitz, Tingting Lei, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: biorxiv

PubMed ID: 34751268

Doi: 10.1101/2021.10.31.466651

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MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1

Authors: Chun Liu, Yang Yang, Guiwen Liang, Aixian Zhang, Feng Xu

Journal: Transpl Immunol

PubMed ID: 34774740

Doi: 10.1016/j.trim.2021.101493

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T cell receptor therapy targeting mutant capicua transcriptional repressor in experimental gliomas

Authors: Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin Löwer, Jana K Sonner, Christopher Krämer, Julia Zaman, Stefanie Jung, Michael O Breckwoldt, Gerald Willimksy, Stefan B Eichmüller, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten, Lukas Bunse

Journal: Clin Cancer Res

PubMed ID: 34782365

Doi: 10.1158/1078-0432.CCR-21-1881

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Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus

Authors: Ebru Destan, Busra Yuksel, Bradley B Tolar, Esra Ayan, Sam Deutsch, Yasuo Yoshikuni, Soichi Wakatsuki, Christopher A Francis, Hasan DeMirci

Journal: Sci Rep

PubMed ID: 34819551

Doi: 10.1038/s41598-021-02180-8

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