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Genetic manipulation of trehalose-6-phosphate synthase results in changes in the soluble sugar profile in transgenic sugarcane stems

Authors: Casey Gabriel, Jean-Jacque Fernhout, Franziska Fichtner, Regina Feil, John E Lunn, Jens Kossmann, James R Lloyd, Christell van der Vyver

Journal: Plant Direct

PubMed ID: 34765864

Doi: 10.1002/pld3.358

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MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs

Authors: Kien Lam Ung, Husam Alsarraf, Laurent Kremer, Mickaël Blaise

Journal: Protein Expr Purif

PubMed ID: 34767949

Doi: 10.1016/j.pep.2021.106014

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A SYBR Green-based real-time RT-PCR assay to differentiate the H1N1 influenza virus lineages

Authors: Yulin Cong, Yixue Sun, Xiaoyu Deng, Haiying Yu, Xiaohuan Lian, Yanlong Cong

Journal: J Virol Methods

PubMed ID: 34848281

Doi: 10.1016/j.jviromet.2021.114387

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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis

Authors: Charles J Cho, Dongkook Park, Jason C Mills

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34816763

Doi: 10.1152/ajpgi.00246.2021

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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Authors: Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

Journal: Oncoimmunology

PubMed ID: 34858730

Doi: 10.1080/2162402X.2021.2005344

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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang, Hongyi Zhang

Journal: Cell Mol Biol Lett

PubMed ID: 34837962

Doi: 10.1186/s11658-021-00295-4

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H, N and C resonance assignments of the Q61H mutant of human KRAS bound to GDP

Authors: Qiwei Huang, Elizabeth Yihui Ng, Qingxin Li, CongBao Kang

Journal: Biomol NMR Assign

PubMed ID: 34787842

Doi: 10.1007/s12104-021-10058-z

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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru

Journal: Cell Rep

PubMed ID: 34758302

Doi: 10.1016/j.celrep.2021.109989

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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses

Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek

Journal: Mol Syst Biol

PubMed ID: 34806839

Doi: 10.15252/msb.202110560

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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome

Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan

Journal: Microbiome

PubMed ID: 34814938

Doi: 10.1186/s40168-021-01147-1

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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection

Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon

Journal: Viruses

PubMed ID: 34835083

Doi: 10.3390/v13112277

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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

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Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts

Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo

Journal: Front Cell Infect Microbiol

PubMed ID: 34869065

Doi: 10.3389/fcimb.2021.758898

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Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick

Journal: MBio

PubMed ID: 34749532

Doi: 10.1128/mBio.02573-21

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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia

Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati

Journal: J Mol Neurosci

PubMed ID: 34811713

Doi: 10.1007/s12031-021-01945-0

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CD4+ effector T cells accelerate Alzheimer's disease in mice

Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman

Journal: J Neuroinflammation

PubMed ID: 34798897

Doi: 10.1186/s12974-021-02308-7

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Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p

Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang

Journal: Cancer Cell Int

PubMed ID: 34844630

Doi: 10.1186/s12935-021-02353-5

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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf

Journal: MBio

PubMed ID: 34724812

Doi: 10.1128/mBio.02558-21

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Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu

Journal: Int J Mol Sci

PubMed ID: 34884691

Doi: 10.3390/ijms222312886

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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response

Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 34818332

Doi: 10.1371/journal.pntd.0009949

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Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction

Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang

Journal: J Clin Invest

PubMed ID: 34752417

Doi: 10.1172/JCI151268

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Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases

Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent

Journal: J Bacteriol

PubMed ID: 34843376

Doi: 10.1128/JB.00498-21

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Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging

Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan

Journal: Sci Rep

PubMed ID: 34845270

Doi: 10.1038/s41598-021-02445-2

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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

Journal: Elife

PubMed ID: 34761751

Doi: 10.7554/eLife.72798

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Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs

Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink

Journal: J Biol Chem

PubMed ID: 34798071

Doi: 10.1016/j.jbc.2021.101421

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang

Journal: Structure

PubMed ID: 34793709

Doi: 10.1016/j.str.2021.10.013

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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae

Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen

Journal: Appl Microbiol Biotechnol

PubMed ID: 34738171

Doi: 10.1007/s00253-021-11661-9

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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee

Journal: Nat Commun

PubMed ID: 34785657

Doi: 10.1038/s41467-021-26733-7

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Authors: Merveille Eguida, Didier Rognan

Journal: J Cheminform

PubMed ID: 34814950

Doi: 10.1186/s13321-021-00567-3

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High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study

Authors: Andres Moreira-Soto, Johanna Maribel Pachamora Diaz, Lilian González-Auza, Xiomara Jeanleny Merino Merino, Alvaro Schwalb, Christian Drosten, Eduardo Gotuzzo, Michael Talledo, Heriberto Arévalo Ramirez, Roxana Peralta Delgado, Spassky Bocanegra Vargas, Jan Felix Drexler

Journal: mSphere

PubMed ID: 34817236

Doi: 10.1128/mSphere.00685-21

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee, Chae Rim Lee, Da-Som Kim, Yang-Mi Her, Jeong Won Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

Journal: Cell Mol Immunol

PubMed ID: 34782759

Doi: 10.1038/s41423-021-00798-2

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A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins

Authors: Gang Liu, Dong-Yun Zuo, Peng Yang, Wei-Jie He, Zheng Yang, Jing-Bo Zhang, Ai-Bo Wu, Shu-Yuan Yi, He-Ping Li, Tao Huang, Yu-Cai Liao

Journal: J Fungi (Basel)

PubMed ID: 34829228

Doi: 10.3390/jof7110941

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The multicellular signalling network of ovarian cancer metastases

Authors: Leah Sommerfeld, Florian Finkernagel, Julia M Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Anna M Sokol, Johannes Graumann, Silke Reinartz, Rolf Müller

Journal: Clin Transl Med

PubMed ID: 34841720

Doi: 10.1002/ctm2.633

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The barley HvSTP13GR mutant triggers resistance against biotrophic fungi

Authors: Caroline Ines Skoppek, Wilko Punt, Marleen Heinrichs, Frank Ordon, Gwendolin Wehner, Jens Boch, Jana Streubel

Journal: Mol Plant Pathol

PubMed ID: 34816582

Doi: 10.1111/mpp.13161

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Influence of flagellin polymorphisms, gene regulation, and responsive memory on the motility of species that cause bacterial spot disease of solanaceous plants

Authors: Maria Laura Malvino, Amie Joy Bott, Cory Edwin Green, Tanvi Majumdar, Sarah Refi Hind

Journal: Mol Plant Microbe Interact

PubMed ID: 34732057

Doi: 10.1094/MPMI-08-21-0211-R

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CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Authors: Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G Venugopala Reddy

Journal: Nat Commun

PubMed ID: 34737298

Doi: 10.1038/s41467-021-26586-0

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment

Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 34740282

Doi: 10.1111/bcpt.13681

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Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region

Authors: Junping Hong, Dongmei Wei, Qian Wu, Ling Zhong, Kaiyun Chen, Yang Huang, Wanlin Zhang, Junyu Chen, Ningshao Xia, Xiao Zhang, Yixin Chen

Journal: Viruses

PubMed ID: 34960650

Doi: 10.3390/v13122380

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The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Authors: Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M Noordermeer, Toshiro K Ohsumi, Nicole Hustedt, Rachel K Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T F Young, Michael Zinda, Manuel Stucki, Daniel Durocher

Journal: Nat Cancer

PubMed ID: 35121901

Doi: 10.1038/s43018-021-00266-w

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A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and Display

Authors: Krista G Freeman, Katherine S Wetzel, Yu Zhang, Kira M Zack, Deborah Jacobs-Sera, Sara M Walters, Dominique J Barbeau, Anita K McElroy, John V Williams, Graham F Hatfull

Journal: Microorganisms

PubMed ID: 34946016

Doi: 10.3390/microorganisms9122414

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Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition

Authors: Adele Vanacore, Giuseppe Vitiello, Alan Wanke, Domenico Cavasso, Luke A Clifton, Lisa Mahdi, María Asunción Campanero-Rhodes, Dolores Solís, Manfred Wuhrer, Simone Nicolardi, Antonio Molinaro, Roberta Marchetti, Alga Zuccaro, Luigi Paduano, Alba Silipo

Journal: Carbohydr Polym

PubMed ID: 34893256

Doi: 10.1016/j.carbpol.2021.118839

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Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

Authors: In-Chi Young, Bogang Wu, Jaclyn Andricovich, Sung-Ting Chuang, Rong Li, Alexandros Tzatsos, Ray-Chang Wu, Mei-Yi Wu

Journal: Cell Rep

PubMed ID: 34818550

Doi: 10.1016/j.celrep.2021.110036

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

Authors: Chensu Wang, Ang Cui, Maurice Bukenya, Aereas Aung, Dikshant Pradhan, Charles A Whittaker, Yash Agarwal, Ayush Thomas, Simon Liang, Parastoo Amlashi, Heikyung Suh, Stefani Spranger, Nir Hacohen, Darrell J Irvine

Journal: Cell Rep

PubMed ID: 34818534

Doi: 10.1016/j.celrep.2021.110021

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Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity

Authors: Debabrata Chowdhury, Jason C Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo, Julio A Landero Figueroa, Kavitha Subramanian Vignesh

Journal: Front Immunol

PubMed ID: 34867993

Doi: 10.3389/fimmu.2021.755961

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Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice

Authors: Hui-Tsu Lin, Cheng-Cheung Chen, Der-Jiang Chiao, Tein-Yao Chang, Xin-An Chen, Jenn-Jong Young, Szu-Cheng Kuo

Journal: Int J Biol Macromol

PubMed ID: 34774590

Doi: 10.1016/j.ijbiomac.2021.11.020

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Nanovaccines Mediated Subcutis-to-Intestine Cascade for Improved Protection against Intestinal Infections

Authors: Xiaofang Zhong, Guangsheng Du, Xuanyu Wang, Yangsen Ou, Hairui Wang, Yining Zhu, Xinyan Hao, Zhiqiang Xie, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun

Journal: Small

PubMed ID: 34825482

Doi: 10.1002/smll.202105530

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Baculovirus Vectors Induce the Production of Interferons in Swine: Their Potential in the Development of Antiviral Strategies

Authors: Guido Nicolás Molina, Sabrina Amalfi, Ignacio Otero, Oscar Taboga, María Paula Molinari

Journal: Vet Sci

PubMed ID: 34822651

Doi: 10.3390/vetsci8110278

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Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

Authors: Tianchuan Zhu, Yuchen Xiao, Xiaojun Meng, Lantian Tang, Bin Li, Zhaoyan Zhao, Qingqin Tan, Hong Shan, Lei Liu, Xi Huang

Journal: J Nanobiotechnology

PubMed ID: 34823562

Doi: 10.1186/s12951-021-01148-0

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Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV

Authors: Ros Chapman, Michiel van Diepen, Nicola Douglass, Shireen Galant, Mohamed Jaffer, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny L Moore, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34835214

Doi: 10.3390/vaccines9111281

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High-throughput and high-dimensional single-cell analysis of antigen-specific CD8 T cells

Authors: Ke-Yue Ma, Alexandra A Schonnesen, Chenfeng He, Amanda Y Xia, Eric Sun, Eunise Chen, Katherine R Sebastian, Yu-Wan Guo, Robert Balderas, Mrinalini Kulkarni-Date, Ning Jiang

Journal: Nat Immunol

PubMed ID: 34811538

Doi: 10.1038/s41590-021-01073-2

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Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

Authors: Benjamin J Evert, Shuxiong Chen, Robyn McConville, Ryan W J Steel, Julie Healer, Justin A Boddey, Lucas Huntimer, Bernd H A Rehm

Journal: npj Vaccines

PubMed ID: 34845267

Doi: 10.1038/s41541-021-00408-2

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Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation

Authors: Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Michele Vendruscolo, Sara Linse

Journal: ACS Chem Neurosci

PubMed ID: 34783519

Doi: 10.1021/acschemneuro.1c00454

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The Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation

Authors: Nina Gillis-Germitsch, Tobias Kockmann, Lars M Asmis, Lucienne Tritten, Manuela Schnyder

Journal: Front Cell Infect Microbiol

PubMed ID: 34796127

Doi: 10.3389/fcimb.2021.753320

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Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Authors: Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Jukka Kervinen, Lars Hellman

Journal: Int J Mol Sci

PubMed ID: 34884431

Doi: 10.3390/ijms222312627

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Patterns of Tetracapsuloides bryosalmonae infection of three salmonid species in large, deep Norwegian lakes

Authors: Tone Jøran Oredalen, Mona Saebø, Tor Atle Mo

Journal: J Fish Dis

PubMed ID: 34747501

Doi: 10.1111/jfd.13548

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Scaling DNA data storage with nanoscale electrode wells

Authors: Bichlien H Nguyen, Christopher N Takahashi, Gagan Gupta, Jake A Smith, Richard Rouse, Paul Berndt, Sergey Yekhanin, David P Ward, Siena D Ang, Patrick Garvan, Hsing-Yeh Parker, Rob Carlson, Douglas Carmean, Luis Ceze, Karin Strauss

Journal: Sci Adv

PubMed ID: 34818035

Doi: 10.1126/sciadv.abi6714

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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Authors: Daniel T Johnson, Jiarong Zhou, Ashley V Kroll, Ronnie H Fang, Ming Yan, Crystal Xiao, Xiufen Chen, Justin Kline, Liangfang Zhang, Dong-Er Zhang

Journal: Leukemia

PubMed ID: 34845316

Doi: 10.1038/s41375-021-01432-w

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Authors: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

Journal: Cell Stem Cell

PubMed ID: 34856120

Doi: 10.1016/j.stem.2021.11.003

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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang

Journal: Cancer Cell Int

PubMed ID: 34844614

Doi: 10.1186/s12935-021-02351-7

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A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum

Authors: Tarkeshwar Kumar, Satarupa Maitra, Abdur Rahman, Souvik Bhattacharjee

Journal: PLoS Pathog

PubMed ID: 34780541

Doi: 10.1371/journal.ppat.1009595

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The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development

Authors: Hidenori Ito, Rika Morishita, Mariko Noda, Tomoki Ishiguro, Masashi Nishikawa, Koh-Ichi Nagata

Journal: J Biol Chem

PubMed ID: 34800437

Doi: 10.1016/j.jbc.2021.101427

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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Authors: Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy

Journal: Microorganisms

PubMed ID: 34835449

Doi: 10.3390/microorganisms9112323

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Positively Regulates Pepper Immunity by Targeting against Inoculation through Modulating Defense-Related Genes

Authors: Ansar Hussain, Muhammad Ifnan Khan, Mohammed Albaqami, Shahzadi Mahpara, Ijaz Rasool Noorka, Mohamed A A Ahmed, Bandar S Aljuaid, Ahmed M El-Shehawi, Zhiqin Liu, Shahid Farooq, Ali Tan Kee Zuan

Journal: Int J Mol Sci

PubMed ID: 34769521

Doi: 10.3390/ijms222112091

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Microinjection of pruritogens in NGF-sensitized human skin

Authors: Hans Jürgen Solinski, Roman Rukwied, Martin Schmelz

Journal: Sci Rep

PubMed ID: 34728705

Doi: 10.1038/s41598-021-00935-x

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The pleiotropic functions of intracellular hydrophobins in aerial hyphae and fungal spores

Authors: Feng Cai, Zheng Zhao, Renwei Gao, Peijie Chen, Mingyue Ding, Siqi Jiang, Zhifei Fu, Pingyong Xu, Komal Chenthamara, Qirong Shen, Günseli Bayram Akcapinar, Irina S Druzhinina

Journal: PLoS Genet

PubMed ID: 34788288

Doi: 10.1371/journal.pgen.1009924

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An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Authors: Anja Ziegler, Judith Olzhausen, Eman Hamza, Ana Stojiljkovic, Michael H Stoffel, Mattia Garbani, Claudio Rhyner, Eliane Marti

Journal: Vet Immunol Immunopathol

PubMed ID: 34800874

Doi: 10.1016/j.vetimm.2021.110351

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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv oryzae

Authors: Yuejing Gui, Dongsheng Tian, Kar Hui Ong, Joanne Chin Yi Teo, Zhongchao Yin

Journal: Transgenic Res

PubMed ID: 34748132

Doi: 10.1007/s11248-021-00290-7

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A super PPR cluster for restoring fertility revealed by genetic mapping, homocap-seq and de novo assembly in cotton

Authors: Bin Gao, Gaofeng Ren, Tianwang Wen, Haiping Li, Xianlong Zhang, Zhongxu Lin

Journal: Theor Appl Genet

PubMed ID: 34811574

Doi: 10.1007/s00122-021-03990-0

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The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain

Authors: María Rodríguez-Muñoz, Elsa Cortés-Montero, Yara Onetti, Pilar Sánchez-Blázquez, Javier Garzón-Niño

Journal: Biomolecules

PubMed ID: 34827679

Doi: 10.3390/biom11111681

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Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection

Authors: Henry Daniell, Smruti K Nair, Nardana Esmaeili, Geetanjali Wakade, Naila Shahid, Prem Kumar Ganesan, Md Reyazul Islam, Ariel Shepley-McTaggart, Sheng Feng, Ebony N Gary, Ali R Ali, Manunya Nuth, Selene Nunez Cruz, Jevon Graham-Wooten, Stephen J Streatfield, Ruben Montoya-Lopez, Paul Kaznica, Margaret Mawson, Brian J Green, Robert Ricciardi, Michael Milone, Ronald N Harty, Ping Wang, David B Weiner, Kenneth B Margulies, Ronald G Collman

Journal: Mol Ther

PubMed ID: 34774754

Doi: 10.1016/j.ymthe.2021.11.008

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Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells

Authors: Yuanyuan Shi, Jian Chen, Wei-Jie Zeng, Miao Li, Wenxue Zhao, Xing-Ding Zhang, Jie Yao

Journal: BMC Biol

PubMed ID: 34789250

Doi: 10.1186/s12915-021-01178-y

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Assessment of in vitro activities of novel modified antimicrobial peptides against clarithromycin resistant Mycobacterium abscessus

Authors: Phantitra Sudadech, Sittiruk Roytrakul, Orawee Kaewprasert, Auttawit Sirichoat, Ploenchan Chetchotisakd, Sakawrat Kanthawong, Kiatichai Faksri

Journal: PLoS ONE

PubMed ID: 34780520

Doi: 10.1371/journal.pone.0260003

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A molecular dynamics-guided mutagenesis identifies two aspartic acid residues involved in the pH-dependent activity of OG-OXIDASE 1

Authors: Anna Scortica, Matteo Capone, Daniele Narzi, Mario Frezzini, Valentina Scafati, Moira Giovannoni, Francesco Angelucci, Leonardo Guidoni, Benedetta Mattei, Manuel Benedetti

Journal: Plant Physiol Biochem

PubMed ID: 34800821

Doi: 10.1016/j.plaphy.2021.11.011

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The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway

Authors: Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang

Journal: Bioengineered

PubMed ID: 34783297

Doi: 10.1080/21655979.2021.2005932

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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Authors: Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L Udaskin, Ahmet Mentes, Richard Huang, Betty P K Poon, Wenguang He, Ivette Valencia-Sama, Claire M Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S Irwin, Jeffrey E Lee, Ming-Sound Tsao, Brian Raught, Christopher B Marshall, Michael Ohh, Mitsuhiko Ikura

Journal: Nat Commun

PubMed ID: 34725361

Doi: 10.1038/s41467-021-26526-y

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Tasquinimod efficacy and S100A9 expression in glucose-treated HREC cells

Authors: Ji Jin, Ji Zhang, Shuyang Bu

Journal: Int Ophthalmol

PubMed ID: 34796432

Doi: 10.1007/s10792-021-02038-y

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DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation

Authors: Ronghui Lou, Weizhen Liu, Rongjie Li, Shanshan Li, Xuming He, Wenqing Shui

Journal: Nat Commun

PubMed ID: 34795227

Doi: 10.1038/s41467-021-26979-1

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Authors: Ehab Al-Moubarak, Holly A Shiels, Yihong Zhang, Chunyun Du, Oliver Hanington, Stephen C Harmer, Christopher E Dempsey, Jules C Hancox

Journal: Cell Mol Life Sci

PubMed ID: 34727194

Doi: 10.1007/s00018-021-03967-8

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A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity

Authors: Wanying Zhang, Haiyang Li, Limin Wang, Shunpei Xie, Yuan Zhang, Ruijiao Kang, Mengjuan Zhang, Panpan Zhang, Yonghui Li, Yanfeng Hu, Min Wang, Linlin Chen, Hongxia Yuan, Shengli Ding, Honglian Li

Journal: Mol Plant Pathol

PubMed ID: 34741560

Doi: 10.1111/mpp.13155

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Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily

Authors: Kyrylo Yu Manoilov, Agnidipta Ghosh, Steven C Almo, Vladislav V Verkhusha

Journal: J Mol Biol

PubMed ID: 34798132

Doi: 10.1016/j.jmb.2021.167359

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Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients

Authors: Belén G Sanchez, Jose M Gasalla, Manuel Sánchez-Chapado, Alicia Bort, Inés Diaz-Laviada

Journal: J Clin Med

PubMed ID: 34884175

Doi: 10.3390/jcm10235474

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Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies

Authors: Rashmi Patel, Siddharth Khare, Vinay S Mahajan

Journal: Clin Lab Med

PubMed ID: 35153048

Doi: 10.1016/j.cll.2021.10.007

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

Authors: Felipe Melo-González, Jorge A Soto, Liliana A González, Jorge Fernández, Luisa F Duarte, Bárbara M Schultz, Nicolás M S Gálvez, Gaspar A Pacheco, Mariana Ríos, Yaneisi Vázquez, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Carolina Iturriaga, Omar P Vallejos, Roslye V Berríos-Rojas, Guillermo Hoppe-Elsholz, Marcela Urzúa, Nicole Bruneau, Rodrigo A Fasce, Judith Mora, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Gang Zeng, Weining Meng, José V González-Aramundiz, Pablo A González, Katia Abarca, Eugenio Ramírez, Alexis M Kalergis, Susan M Bueno

Journal: Front Immunol

PubMed ID: 34858404

Doi: 10.3389/fimmu.2021.747830

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DNA Matrix Operation Based on the Mechanism of the DNAzyme Binding to Auxiliary Strands to Cleave the Substrate

Authors: Shaoxia Xu, Yuan Liu, Shihua Zhou, Qiang Zhang, Nikola K Kasabov

Journal: Biomolecules

PubMed ID: 34944442

Doi: 10.3390/biom11121797

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Long Non-Coding RNA Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development

Authors: Elpinickie Ninou, Artemis Michail, Panagiotis K Politis

Journal: Front Cell Dev Biol

PubMed ID: 34900989

Doi: 10.3389/fcell.2021.726857

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Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

Authors: Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya M Colpitts, Stephanie E Mohr, Yanhui Hu, Norbert Perrimon

Journal: Nat Commun

PubMed ID: 34819517

Doi: 10.1038/s41467-021-27129-3

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SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells

Authors: Dante Barreda, César Santiago, Juan R Rodríguez, José F Rodríguez, José M Casasnovas, Isabel Mérida, Antonia Ávila-Flores

Journal: Cells

PubMed ID: 34943787

Doi: 10.3390/cells10123279

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Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Authors: Wanqiu Li, Linlin Wang, Bradley M. Wierbowski, Mo Lu, Feitong Dong, Wenchen Liu, Sisi Li, Peiyi Wang, Adrian Salic, Xin Gong

Journal: Nature Communications

Doi: doi.org/10.1038/s41467-021-27257-w

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ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments

Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal

Journal: Molecules

Doi: 10.3390/molecules26237155

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A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library

Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun

Journal: Front Oncol.

PubMed ID: 34912719

Doi: doi.org/10.3389/fonc.2021.781046

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SARS-CoV-2 exposure in wild white-tailed deer ()

Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34732584

Doi: 10.1073/pnas.2114828118

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Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Authors: Mohamed S Abdel-Hakeem, Sasikanth Manne, Jean-Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L Johnson, Josephine R Giles, Divij Mathew, Allison R Greenplate, Golnaz Vahedi, E John Wherry

Journal: Nat Immunol

PubMed ID: 34588688

Doi: 10.1038/s41590-021-01057-2

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Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China

Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan

Journal: Innovation (N Y)

PubMed ID: 34746904

Doi: 10.1016/j.xinn.2021.100181

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Heterologous Expression of a Thermostable Chitinase from and Its Application for High Yield Production of Glucosamine from Shrimp Shell

Authors: Yongmei Lyu, Feng Zheng, Chuanxing Qiu, Meng Wang, Dujun Wang, Xiaoyang Zhang, Josef Voglmeir, Li Liu, Xiaohong Yu

Journal: Foods

PubMed ID: 34829089

Doi: 10.3390/foods10112808

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Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Authors: Sun Hee Moon, Yihong Kaufmann, Ryoichi Fujiwara, En Huang