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Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

Products & Services: DNA Sequencing

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

Authors: Taylor P Light, Delphine Brun, Pablo Guardado-Calvo, Riccardo Pederzoli, Ahmed Haouz, Frank Neipel, Félix A Rey, Kalina Hristova, Marija Backovic

Journal: PLoS Biol

PubMed ID: 34499637

Doi: 10.1371/journal.pbio.3001392

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A pH-engineering regenerative DNA tetrahedron ECL biosensor for the assay of SARS-CoV-2 RdRp gene based on CRISPR/Cas12a -activity

Authors: Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie

Journal: Chem Eng J

PubMed ID: 34539224

Doi: 10.1016/j.cej.2021.132472

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Visualized Multigene Editing System for

Authors: Cen Li, Jingwen Zhou, Shengqi Rao, Guocheng Du, Song Liu

Journal: ACS Synth Biol

PubMed ID: 34555894

Doi: 10.1021/acssynbio.1c00231

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in

Authors: Jianhua Li, Fanglin Xu, Dongni Ji, Chenfei Tian, Yuwei Sun, Ishmael Mutanda, Yuhong Ren, Yong Wang

Journal: Metab Eng Commun

PubMed ID: 34631421

Doi: 10.1016/j.mec.2021.e00185

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Oral Delivery of Novel Recombinant Elicit High Protection against Pulmonary and Skin Infections

Authors: Na Pan, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 34579221

Doi: 10.3390/vaccines9090984

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Metabolic engineering of Deinococcus radiodurans for pinene production from glycerol

Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar, Ivan Mijakovic

Journal: Microb Cell Fact

PubMed ID: 34565367

Doi: 10.1186/s12934-021-01674-4

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COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Authors: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arriga, Abraham Nyska, Pietro Di Lucia, Davide Marotta, Elisa Bono, Leonardo Giustini, Eleonora Sala, Chiara Perucchini, Jemma Paterson, Kathryn Ann Ryan, Amy-Rose Challis, Giulia Matusali, Francesca Colavita, Gianfranco Caselli, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Lorena Donnici, Matteo Conti, Raffaele De Francesco, Mirela Kuka, Gennaro Ciliberto, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Luca G Guidotti, Lucio Rovati, Matteo Iannacone, Luigi Aurisicchio

Journal: Mol Ther

PubMed ID: 34547465

Doi: 10.1016/j.ymthe.2021.09.011

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Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications

Authors: Ah-Young Song, Hyori Kim, Jung Min Kim, Sang-Hyun Hwang, Dae-Hyun Ko, Hun Sik Kim

Journal: ACS Appl Mater Interfaces

PubMed ID: 34486371

Doi: 10.1021/acsami.1c08986

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

Authors: Maria Y Sachkova, Eva-Lena Nordmann, Joan J Soto-Àngel, Yasmin Meeda, Bartłomiej Górski, Benjamin Naumann, Daniel Dondorp, Marios Chatzigeorgiou, Maike Kittelmann, Pawel Burkhardt

Journal: Curr Biol

PubMed ID: 34587474

Doi: 10.1016/j.cub.2021.09.005

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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T Lee, Sizun Jiang, Matthias S Matter, Carol H Yan, Jonathan B Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M Schürch, Pauline Chu, Han Chen, Anna K Stalder, David R McIlwain, Nicole A Borchard, Phillip A Gall, Sachi S Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M Duran, Kirsten D Mertz, Peter H Hwang, Jasmin D Haslbauer, Peter K Jackson, Thomas Menter, Raul Andino, Peter D Canoll, Adam S DeConde, Zara M Patel, Alexandar Tzankov, Garry P Nolan, Jayakar V Nayak

Journal: Cell Rep Med

PubMed ID: 34604819

Doi: 10.1016/j.xcrm.2021.100421

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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

Authors: Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark

Journal: Nat Commun

PubMed ID: 34489474

Doi: 10.1038/s41467-021-25570-y

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Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex

Authors: Xi Liu, Laixing Zhang, Yu Xiu, Teng Gao, Ling Huang, Yongchao Xie, Lingguang Yang, Wenhe Wang, Peiyi Wang, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nucleic Acids Res

PubMed ID: 34432044

Doi: 10.1093/nar/gkab738

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Engineering high coenzyme Q tomato

Authors: Hang Fan, Yan Liu, Chen-Yi Li, Yan Jiang, Jiao-Jiao Song, Lei Yang, Qing Zhao, Yong-Hong Hu, Xiao-Ya Chen, Jing-Jing Xu

Journal: Metab Eng

PubMed ID: 34555495

Doi: 10.1016/j.ymben.2021.09.007

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Structural and Kinetic Insights Into the Molecular Basis of Salt Tolerance of the Short-Chain Glucose-6-Phosphate Dehydrogenase From

Authors: Nicolás Fuentes-Ugarte, Sixto M Herrera, Pablo Maturana, Victor Castro-Fernandez, Victoria Guixé

Journal: Front Microbiol

PubMed ID: 34650535

Doi: 10.3389/fmicb.2021.730429

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Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells

Authors: Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa

Journal: FEBS Lett

PubMed ID: 34418081

Doi: 10.1002/1873-3468.14183

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The immunogenomic landscape of resected intrahepatic cholangiocarcinoma

Authors: Fernando Carapeto, Behnaz Bozorgui, Rachna T Shroff, Sharmeen Chagani, Luisa Solis Soto, Wai Chin Foo, Ignacio Wistuba, Funda Meric-Bernstam, Ahmed Shalaby, Milind Javle, Anil Korkut, Lawrence N Kwong

Journal: Hepatology

PubMed ID: 34510503

Doi: 10.1002/hep.32150

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CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice

Authors: Chandra N Roy, Mariana A Benitez Moreno, Chris Kline, Zandrea Ambrose

Journal: J Virol

PubMed ID: 34232063

Doi: 10.1128/JVI.00449-21

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Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Authors: Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou

Journal: Front Mol Biosci

PubMed ID: 34568426

Doi: 10.3389/fmolb.2021.720370

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Corrigendum: Reductive Power Generated by Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Authors: Thabatta L S A Rosa, Maria Angela M Marques, Zachary DeBoard, Kelly Hutchins, Carlos Adriano A Silva, Christine R Montague, Tianao Yuan, Julio J Amaral, Georgia C Atella, Patrícia S Rosa, Katherine A Mattos, Brian C VanderVen, Ramanuj Lahiri, Nicole S Sampson, Patrick J Brennan, John T Belisle, Maria Cristina V Pessolani, Marcia Berrêdo-Pinho

Journal: Front Cell Infect Microbiol

PubMed ID: 34650934

Doi: 10.3389/fcimb.2021.765326

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A Novel TLR4-Binding Domain of Peroxiredoxin From Triggers NLRP3 Inflammasome Activation in Macrophages

Authors: Xia Li, Meng Feng, Yanqing Zhao, Yuhan Zhang, Ruixue Zhou, Hang Zhou, Zhen Pang, Hiroshi Tachibana, Xunjia Cheng

Journal: Front Immunol

PubMed ID: 34659265

Doi: 10.3389/fimmu.2021.758451

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Two novel SARS-CoV-2 surrogate virus neutralization assays are suitable for assessing successful immunization with mRNA-1273

Authors: Alexander Krüttgen, Maike Lauen, Hanna Klingel, Matthias Imöhl, Michael Kleines

Journal: J Virol Methods

PubMed ID: 34563583

Doi: 10.1016/j.jviromet.2021.114297

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Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics

Authors: Yuan Zhou, Li Zhang, You-Hua Xie, Jian Wu

Journal: Lab Invest

PubMed ID: 34497366

Doi: 10.1038/s41374-021-00663-w

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Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia

Authors: Lina Abou Saleh, Abigail Boyd, Ileana V Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A Barrington, Wito Richter

Journal: FASEB J

PubMed ID: 34383981

Doi: 10.1096/fj.202100495R

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Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Authors: Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez, Simon Trowitzsch

Journal: Nat Commun

PubMed ID: 34584079

Doi: 10.1038/s41467-021-25870-3

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Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro

Authors: Gang Wang, Jun Guan, Guojun Li, Fengtian Wu, Qin Yang, Chunhong Huang, Junwei Shao, Lichen Xu, Zixuan Guo, Qihui Zhou, Haihong Zhu, Zhi Chen

Journal: Dis Markers

PubMed ID: 34603560

Doi: 10.1155/2021/6803510

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Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression

Authors: Sheng Xu, Huanhuan Tan, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Ping Zhao, Qingyou Xia, Feng Wang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34525798

Doi: 10.1021/acsami.1c08409

Products & Services: Proteins, Expression, Isolation and Analysis

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation

Authors: Lennart Pusch, Regine Brox, Karl Scheuer, Tadahiro Yokosawa, Mingjian Wu, Benjamin Apeleo Zubiri, Erdmann Spiecker, Klaus D Jandt, Dagmar Fischer, Holger Hackstein

Journal: Nanomedicine (Lond)

PubMed ID: 34523349

Doi: 10.2217/nnm-2021-0022

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of an Heparin-Binding Epidermal Growth Factor Domain Antibody from a Phage Library and Analysis of Its Inhibitory Effects in SKOV3 Cells

Authors: Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen

Journal: Cancer Biother Radiopharm

PubMed ID: 34529926

Doi: 10.1089/cbr.2021.0123

Products & Services: Proteins, Expression, Isolation and Analysis

METTL3-mediated mA RNA methylation promotes the anti-tumour immunity of natural killer cells

Authors: Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian

Journal: Nat Commun

PubMed ID: 34535671

Doi: 10.1038/s41467-021-25803-0

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Authors: Qiufeng Liu, Dehua Yang, Youwen Zhuang, Tristan I Croll, Xiaoqing Cai, Antao Dai, Xinheng He, Jia Duan, Wanchao Yin , Chenyu Ye, Fulai Zhou, Beili Wu, Qiang Zhao, H Eric Xu, Ming-Wei Wang, Yi Jiang

Journal: Nat Chem Biol.

PubMed ID: 34556862

Doi: 10.1038/s41589-021-00841-3

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Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity

Authors: Rosa Sottile, M Kazim Panjwani, Colleen M Lau, Anthony F Daniyan, Kento Tanaka, Juliet N Barker, Renier J Brentjens, Joseph C Sun, Jean-Benoît Le Luduec, Katharine C Hsu

Journal: Sci Immunol

PubMed ID: 34559552

Doi: 10.1126/sciimmunol.abe6968

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Combining spike- and nucleocapsid-based vaccines improves distal control of SARS-CoV-2

Authors: Tanushree Dangi, Jacob Class, Nicole Palacio, Justin M Richner, Pablo Penaloza MacMaster

Journal: Cell Rep

PubMed ID: 34450033

Doi: 10.1016/j.celrep.2021.109664

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Identification of BvgA-Dependent and BvgA-Independent Small RNAs (sRNAs) in Bordetella pertussis Using the Prokaryotic sRNA Prediction Toolkit ANNOgesic

Authors: Kyung Moon, Minji Sim, Chin-Hsien Tai, Kyungyoon Yoo, Charlotte Merzbacher, Sung-Huan Yu, David D Kim, Jaehyun Lee, Konrad U Förstner, Qing Chen, Scott Stibitz, Leslie G Knipling, Deborah M Hinton

Journal: Microbiol Spectr

PubMed ID: 34550019

Doi: 10.1128/Spectrum.00044-21

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Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Authors: Byron Shue, Abhilash I Chiramel, Berati Cerikan, Thu-Hien To, Sonja Frölich, Stephen M Pederson, Emily N Kirby, Nicholas S Eyre, Ralf F W Bartenschlager, Sonja M Best, Michael R Beard

Journal: J Virol

PubMed ID: 34586867

Doi: 10.1128/JVI.00596-21

Products & Services: Proteins, Expression, Isolation and Analysis

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

Journal: J Clin Invest

PubMed ID: 34623328

Doi: 10.1172/JCI145472

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Authors: Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl

Journal: Elife

PubMed ID: 34486521

Doi: 10.7554/eLife.71420

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Baculovirus infection affects caterpillar chemoperception

Authors: Angel Llopis-Giménez, Gabriela Caballero-Vidal, Emmanuelle Jacquin-Joly, Cristina Maria Crava, Salvador Herrero

Journal: Insect Biochem Mol Biol

PubMed ID: 34536505

Doi: 10.1016/j.ibmb.2021.103648

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Ackr3-Venus knock-in mouse lights up brain vasculature

Authors: Aliza T Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L Kieffer

Journal: Mol Brain

PubMed ID: 34583741

Doi: 10.1186/s13041-021-00862-y

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Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Authors: Pei Dai, Zhongxiang Tang, Pinglang Ruan, Ousman Bajinka, Dan Liu, Yurong Tan

Journal: Front Oncol

PubMed ID: 34604035

Doi: 10.3389/fonc.2021.699847

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Antibody Screening Results for Anti-Nucleocapsid Antibodies Toward the Development of a Lateral Flow Assay to Detect SARS-CoV-2 Nucleocapsid Protein

Authors: David M Cate, Joshua D Bishop, Helen V Hsieh, Veronika A Glukhova, Luis F Alonzo, H Gleda Hermansky, Brianda Barrios-Lopez, Benjamin D Grant, Caitlin E Anderson, Ethan Spencer, Samantha Kuhn, Ryan Gallagher, Rafael Rivera, Crissa Bennett, Samantha A Byrnes, John T Connelly, Puneet K Dewan, David S Boyle, Bernhard H Weigl, Kevin P Nichols

Journal: ACS Omega

PubMed ID: 34608447

Doi: 10.1021/acsomega.1c01253

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Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection

Authors: Hai Li, Hu Ren, Yan Zhang, Lei Cao, Wenbo Xu

Journal: Sci Rep

PubMed ID: 34545126

Doi: 10.1038/s41598-021-97535-6

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High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population

Authors: Arshad A Pandith, Usma Manzoor, Ina Amin, Abida Ahmad, Masarat Rashid, Mahrukh H Zargar, Shayesta Rah, Fayaz A Dar, Iqbal Qasim, Dheera Sanadhya

Journal: Arch Gynecol Obstet

PubMed ID: 34542677

Doi: 10.1007/s00404-021-06235-z

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Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes

Authors: Thomas Steele, Anhao Sam, Shawna Evans, Elizabeth Browning, Sheryl Krig, Katelyn Macias, Adarsh Konda, Salma Siddiqui, Blythe Durbin-Johnson, Paramita Ghosh, Ruth Vinall

Journal: Cancers (Basel)

PubMed ID: 34503235

Doi: 10.3390/cancers13174425

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Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart

Authors: Yanbo Tang, Kevin T Kline, Xiaoying S Zhong, Ying Xiao, Haifeng Lian, Jun Peng, Xiaowei Liu, Don W Powell, Guodu Tang, Qingjie Li

Journal: PLoS ONE

PubMed ID: 34543287

Doi: 10.1371/journal.pone.0257280

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Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

Authors: Shang Yu Gong, Debashree Chatterjee, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Romain Gasser, Yuxia Bo, Dani Vézina, Guillaume Goyette, Gabrielle Gendron-Lepage, Halima Medjahed, Michel Roger, Marceline Côté, Andrés Finzi

Journal: Virology

PubMed ID: 34536797

Doi: 10.1016/j.virol.2021.09.001

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Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation

Authors: Jacquelyn R Dayton, Yinyu Yuan, Lisa P Pacumio, Bryce G Dorflinger, Samantha C Yoo, Mariah J Olson, Sara I Hernández-Suárez, Moira M McMahon, Lillian Cruz-Orengo

Journal: Front Cell Neurosci

PubMed ID: 34557075

Doi: 10.3389/fncel.2021.683687

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Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Authors: Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li

Journal: Int J Biol Macromol

PubMed ID: 34499954

Doi: 10.1016/j.ijbiomac.2021.08.232

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Genome-scale identification of () family genes and molecular characterization of their responses to diverse nutrient stresses in allotetraploid rapeseed

Authors: Ying Liu, Ying-Peng Hua, Huan Chen, Ting Zhou, Cai-Peng Yue, Jin-Yong Huang

Journal: PeerJ

PubMed ID: 34603847

Doi: 10.7717/peerj.12007

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Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

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Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Authors: John Pang, Nam Nguyen, Jens Luebeck, Laurel Ball, Andrey Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, Sayed Sadat, Paul S Mischel, Guorong Xu, Kathleen Fisch, Theresa Guo, Gabrielle Cahill, Bharat Panuganti, Vineet Bafna, Joseph Califano

Journal: Clin Cancer Res

PubMed ID: 34548317

Doi: 10.1158/1078-0432.CCR-21-2484

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A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

Authors: Juliano Alves, Laurie Engel, Renata de Vasconcelos Cabral, Eduardo L Rodrigues, Liane de Jesus Ribeiro, Luiza M Higa, Orlando da Costa Ferreira Júnior, Terezinha Marta P P Castiñeiras, Isabela de Carvalho Leitão, Amilcar Tanuri, Said A Goueli, Hicham Zegzouti

Journal: Sci Rep

PubMed ID: 34531417

Doi: 10.1038/s41598-021-97330-3

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The impact of chromophore choice on the assembly kinetics and primary photochemistry of a red/green cyanobacteriochrome

Authors:

Journal: Phys Chem Chem Phys

PubMed ID: 34374395

Doi: 10.1039/d1cp02696h

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DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Authors: Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34568799

Doi: 10.1016/j.isci.2021.103086

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Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Authors: Raymond Rowland, Alberto Brandariz-Nuñez

Journal: Microbiol Spectr

PubMed ID: 34494876

Doi: 10.1128/Spectrum.01199-21

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The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Authors: Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie

Journal: Sci Adv

PubMed ID: 34516906

Doi: 10.1126/sciadv.abg9241

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Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding

Authors: Abigail E Burgess, Torsten Kleffmann, Peter D Mace

Journal: J Mol Biol

PubMed ID: 34536441

Doi: 10.1016/j.jmb.2021.167242

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Impact of glgA1, glgA2 or glgC overexpression on growth and glycogen production in Synechocystis sp PCC 6803

Authors: Sandra Mittermair, Gergely Lakatos, Cecilia Nicoletti, Karolína Ranglová, João Câmara Manoel, Tomáš Grivalský, Daniyar Malikuly Kozhan, Jiří Masojídek, Juliane Richter

Journal: J Biotechnol

PubMed ID: 34481001

Doi: 10.1016/j.jbiotec.2021.08.012

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Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43

Authors: Takashi Shiroyama, Kouji Fukuyama, Motohiro Okada

Journal: Int J Mol Sci

PubMed ID: 34576176

Doi: 10.3390/ijms221810013

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Switchable immune modulator for tumor-specific activation of anticancer immunity

Authors: Yu Zhao, Yu-Qing Xie, Simon Van Herck, Sina Nassiri, Min Gao, Yugang Guo, Li Tang

Journal: Sci Adv

PubMed ID: 34516776

Doi: 10.1126/sciadv.abg7291

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A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Authors: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J Marrink, Cornelius Gati, Albert Guskov

Journal: Comput Struct Biotechnol J

PubMed ID: 34630942

Doi: 10.1016/j.csbj.2021.09.015

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Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection

Authors: Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li, Xueping Zhou

Journal: PLoS Pathog

PubMed ID: 34570833

Doi: 10.1371/journal.ppat.1009956

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The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients

Authors: Chanmi Kim, Iqra Latif, Durga P Neupane, Gi Young Lee, Ryan S Kwon, Alia Batool, Qasim Ahmed, Muhammad Usman Qamar, Jeongmin Song

Journal: PLoS ONE

PubMed ID: 34582469

Doi: 10.1371/journal.pone.0257744

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A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan

Authors: Marcus Bäumgen, Theresa Dutschei, Daniel Bartosik, Christoph Suster, Lukas Reisky, Nadine Gerlach, Christian Stanetty, Marko D Mihovilovic, Thomas Schweder, Jan-Hendrik Hehemann, Uwe T Bornscheuer

Journal: J Biol Chem

PubMed ID: 34547290

Doi: 10.1016/j.jbc.2021.101210

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Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons

Authors: Hung-En Hsia, Johanna Tüshaus, Xiao Feng, Laura I Hofmann, Benedikt Wefers, Denise K Marciano, Wolfgang Wurst, Stefan F Lichtenthaler

Journal: FASEB J

PubMed ID: 34390512

Doi: 10.1096/fj.202100475R

Products & Services: Proteins, Expression, Isolation and Analysis

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

Authors: Andrew J Monteith, Jeanette M Miller, C Noel Maxwell, Walter J Chazin, Eric P Skaar

Journal: Sci Adv

PubMed ID: 34516771

Doi: 10.1126/sciadv.abj2101

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Design and Selection of Engineered Lytic Proteins With Decolonizing Activity

Authors: Diana Gutiérrez, Lorena Rodríguez-Rubio, Patricia Ruas-Madiedo, Lucía Fernández, Ana Belén Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar García, Ana Rodríguez

Journal: Front Microbiol

PubMed ID: 34594314

Doi: 10.3389/fmicb.2021.723834

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A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing

Authors: Bokyung Son, Jennifer Patterson-West, Melissa Arroyo-Mendoza, Revathy Ramachandran, James R Iben, Jingen Zhu, Venigalla Rao, Emilios K Dimitriadis, Deborah M Hinton

Journal: Nucleic Acids Res

PubMed ID: 34365505

Doi: 10.1093/nar/gkab678

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miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Authors: Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao

Journal: Mol Med Rep

PubMed ID: 34468015

Doi: 10.3892/mmr.2021.12392

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Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells

Authors: Guojie Chen, Kai Wang, Guoshu Li, Leidong Wang, Yangyang Xiao, Bo Chen

Journal: Oncol Res

PubMed ID: 34588094

Doi: 10.3727/096504021X16328213967104

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Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios-Athanasios Dimopoulos

Journal: Br J Haematol

PubMed ID: 34528249

Doi: 10.1111/bjh.17841

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A human antibody against human endothelin receptor type A that exhibits antitumor potency

Authors: Man-Seok Ju, Hye-Mi Ahn, Seong-Gu Han, Sanghwan Ko, Jung-Hyun Na, Migyeong Jo, Chung Su Lim, Byoung Joon Ko, Yeon Gyu Yu, Won-Kyu Lee, Youn-Jae Kim, Sang Taek Jung

Journal: Exp Mol Med

PubMed ID: 34588605

Doi: 10.1038/s12276-021-00678-9

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Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice

Authors: Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Journal: Plant Biotechnol J

PubMed ID: 34582079

Doi: 10.1111/pbi.13716

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Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2

Authors: Jorge Hernández-Bello, José Javier Morales-Núñez, Andrea Carolina Machado-Sulbarán, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Paulina Balcázar-Félix, Jesús Alberto Gutiérrez-Brito, José Alvaro Lomelí-Nieto, José Francisco Muñoz-Valle

Journal: Vaccines (Basel)

PubMed ID: 34579284

Doi: 10.3390/vaccines9091047

Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34582499

Doi: 10.1371/journal.pone.0258005

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An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates

Authors: Stephen Geoffrey Holt, Sally Mahmoud, Wasim Ahmed, Juan Manuel Acuna, Ayman Kamal Al Madani, Islam Eltantawy, Walid Abbas Zaher, Gareth John Goodier, Nawal Ahmed Al Kaabi, Ali Abdulkareem Al Obaidli

Journal: Nephrology (Carlton)

PubMed ID: 34569677

Doi: 10.1111/nep.13980

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Authors: Izzy Owen, Debra Yee, Hala Wyne, Theodora Myrto Perdikari, Victoria Johnson, Jeremy Smyth, Robert Kortum, Nicolas L Fawzi, Frank Shewmaker

Journal: J Cell Sci

PubMed ID: 34357401

Doi: 10.1242/jcs.258578

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ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier

Authors: Xihua Yue , Yi Qian , Lianhui Zhu , Bopil Gim, Mengjing Bao , Jie Jia , Shuaiyang Jing , Yijing Wang , Chuanting Tan , Francesca Bottanelli , Pascal Ziltener , Sunkyu Choi , Piliang Hao , Intaek Lee

Journal: BMC Biol

PubMed ID: 34493279

Doi: 10.1186/s12915-021-01137-7

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Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation

Authors: Hongyi Zhou, Huabo Su, Weiqin Chen

Journal: Int J Mol Sci

PubMed ID: 34502418

Doi: 10.3390/ijms22179509

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A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Authors: Fei Wang, Zhimin Wan, Jinsen Wu, Yajuan Wang, Hui Fu, Hongxia Shao, Kun Qian, Wei Gao, Jianqiang, Aijian Qin

Journal: Frontiers in Microbiology

Doi: 10.3389/fmicb.2021.730449

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Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identification of SARS-CoV-2 from clinical samples

Authors: Jiajie Liang, Peijun Teng, Wei Xiao, Guanbo He, Qifang Song, Ying Zhang, Bin Peng, Gan Li, Liangshan Hu, Donglin Cao, Yong Tang

Journal: J Nanobiotechnology

PubMed ID: 34496881

Doi: 10.1186/s12951-021-01021-0

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Authors: Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K Olsen, Tony T Huang

Journal: Cell Rep

PubMed ID: 34547223

Doi: 10.1016/j.celrep.2021.109754

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Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch

Authors: Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 34550864

Doi: 10.1080/10826068.2021.1977949

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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

Authors: Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami

Journal: Nat Commun

PubMed ID: 34518546

Doi: 10.1038/s41467-021-25679-0

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Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Authors: Jiawei Chen, Xinhai Cui, Aiwu Li, Guowei Li, Fengyin Sun

Journal: Urol Int

PubMed ID: 34569527

Doi: 10.1159/000518644

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NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

Authors: Bing Wang, Dmitri Svetlov, Irina Artsimovitch

Journal: Nucleic Acids Res

PubMed ID: 34352100

Doi: 10.1093/nar/gkab677

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A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress

Authors: Kaitlin Casanova-Hampton, Alexis Carey, Sarah Kassam, Alyssa Garner, George L Donati, Shankar Thangamani, Sargurunathan Subashchandrabose

Journal: Metallomics

PubMed ID: 34415046

Doi: 10.1093/mtomcs/mfab052

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De novo design of tyrosine and serine kinase-driven protein switches

Authors: Nicholas B Woodall, Zara Weinberg, Jesslyn Park, Florian Busch, Richard S Johnson, Mikayla J Feldbauer, Michael Murphy, Maggie Ahlrichs, Issa Yousif, Michael J MacCoss, Vicki H Wysocki, Hana El-Samad, David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 34518698

Doi: 10.1038/s41594-021-00649-8

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The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

Authors: Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizbé Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Strauss

Journal: ACS Chem Biol

PubMed ID: 34582681

Doi: 10.1021/acschembio.1c00535

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Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

Authors: Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson

Journal: BMC Vet Res

PubMed ID: 34579716

Doi: 10.1186/s12917-021-03030-5

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Molecular basis of human ATM kinase inhibition

Authors: K Stakyte, M Rotheneder, K Lammens, J D Bartho, U Grädler, T Fuchß, U Pehl, A Alt, E van de Logt, K P Hopfner

Journal: Nat Struct Mol Biol

PubMed ID: 34556870

Doi: 10.1038/s41594-021-00654-x

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Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple

Authors: Pengxiang Chen, Fang Zhi, Xuewei Li, Wenyun Shen, Mingjia Yan, Jieqiang He, Chana Bao, Tianle Fan, Shuangxi Zhou, Fengwang Ma, Qingmei Guan

Journal: Plant Physiol

PubMed ID: 34618120

Doi: 10.1093/plphys/kiab420

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Spectroscopic evidence of tetanus toxin translocation domain bilayer-induced refolding and insertion

Authors: Pierce T O'Neil, Victor Vasquez-Montes, Liskin Swint-Kruse, Michael R Baldwin, Alexey S Ladokhin

Journal: Biophys J

PubMed ID: 34555358

Doi: 10.1016/j.bpj.2021.09.030

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Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice

Authors: Xiaoling Cao, Yan Tian, Vi Nguyen, Yuping Zhang, Chao Gao, Rong Yin, Wayne Carver, Daping Fan, Helmut Albrecht, Taixing Cui, Wenbin Tan

Journal: FASEB J

PubMed ID: 34365657

Doi: 10.1096/fj.202002742RR

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Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing

Authors: Sarah A Schoonraad, Kristine M Fischenich, Kevin N Eckstein, Victor Crespo-Cuevas, Lea M Savard, Archish Muralidharan, Andrew A Tomaschke, Asais Camila Uzcategui, Mark A Randolph, Robert R McLeod, Virginia L Ferguson, Stephanie J Bryant

Journal: Biofabrication

PubMed ID: 34479218

Doi: 10.1088/1758-5090/ac23ab

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Serological Assays for Assessing Postvaccination SARS-CoV-2 Antibody Response

Authors: Sally A Mahmoud, Subhashini Ganesan, Shivaraj Naik, Safaa Bissar, Isra Al Zamel, K N Warren, Walid A Zaher, Gulfaraz Khan

Journal: Microbiol Spectr

PubMed ID: 34585943

Doi: 10.1128/Spectrum.00733-21

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Isotype-Specific Fc Effector Functions Enhance Antibody-Mediated Rift Valley Fever Virus Protection

Authors: Haley N Cartwright, Dominique J Barbeau, Anita K McElroy

Journal: mSphere

PubMed ID: 34494884

Doi: 10.1128/mSphere.00556-21

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Lysine Residues in the MK-Rich Region Are Not Required for Binding of the PbsP Protein From Group B Streptococci to Plasminogen

Authors: Francesco Coppolino, Letizia Romeo, Giampiero Pietrocola, Germana Lentini, Giuseppe Valerio De Gaetano, Giuseppe Teti, Roberta Galbo, Concetta Beninati

Journal: Front Cell Infect Microbiol

PubMed ID: 34568085

Doi: 10.3389/fcimb.2021.679792

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Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

Authors: Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C L Wong, Jianxun Qi, Wenjie Tan, George Fu Gao

Journal: MBio

PubMed ID: 34579576

Doi: 10.1128/mBio.02220-21

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Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Authors: Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Journal: Immunity

PubMed ID: 34525338

Doi: 10.1016/j.immuni.2021.08.022

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