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Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to confer full host defense against tospovirus infection

Authors: Hongyu Chen , Xin Qian , Xiaojiao Chen , Tongqing Yang , Mingfeng Feng , Jing Chen , Ruixiang Cheng , Hao Hong , Ying Zheng , Yuzhen Mei , Danyu Shen , Yi Xu , Min Zhu , Xin Shun Ding , Xiaorong Tao

Journal: New Phytol

PubMed ID: 34096619

Doi: 10.1111/nph.17535

Products & Services: Gene Synthesis

Assessment of IsPETase-Assisted Depolymerization of Terephthalate Aromatic Polyesters and the Effect of the Thioredoxin Fusion Domain

Authors: Paula Wagner-Egea ,Virginia Tosi ,Ping Wang ,Carl Grey,Baozhong Zhang and Javier A. Linares-Pastén

Journal: applied sciences

Doi: 10.3390/app11188315

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Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8 T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma

Authors: Hailin Zhang, Yonghui Zhang, Jie Dong, Shuguang Zuo, Gang Meng, Junhua Wu, Jiwu Wei

Journal: Cell Oncol (Dordr)

PubMed ID: 34491549

Doi: 10.1007/s13402-021-00633-w

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Knockdown of lncRNA TUG1 protects lens epithelial cells from oxidative stress-induced injury by regulating miR-196a-5p expression in age-related cataracts

Authors: Qimin Shen, Tian Zhou

Journal: Exp Ther Med

PubMed ID: 34630641

Doi: 10.3892/etm.2021.10721

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Seroprevalence and detection of Trypanosoma cruzi in dogs living in a non-endemic area for Chagas disease in the legal Amazon region, Brazil

Authors: Thaliane França Costa, Ana Vitória Verde Oliveira Rocha, Leandro Macedo Miranda, Larissa Fernanda Soares Lima, Fred Luciano Neves Santos, Ângelo Antônio Oliveira Silva, Fernando Almeida-Souza, Anaiá da Paixão Sevá, Aline Diniz Cabral, Márcia Aparecida Sperança, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Andréa Pereira da Costa

Journal: Vet Parasitol Reg Stud Reports

PubMed ID: 34879958

Doi: 10.1016/j.vprsr.2021.100648

Products & Services: Proteins, Expression, Isolation and Analysis

A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

Authors: Houyu Ju, Zhenrong Hu, Dongliang Wei, Jinyun Huang, Xinyi Zhang, Mengyu Rui, Zhi Li, Xiaomeng Zhang, Jingzhou Hu, Wei Guo, Guoxin Ren

Journal: Cancer Commun (Lond)

PubMed ID: 34498800

Doi: 10.1002/cac2.12213

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Manipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria

Authors: Nhan D T Tram, Vanitha Selvarajan, Alister Boags, Devika Mukherjee, Jan K Marzinek, Bernadette Cheng, Zi-Chen Jiang, Pascal Goh, Jun-Jie Koh, Jeanette W P Teo, Peter J Bond, Pui Lai Rachel Ee

Journal: Acta Biomater

PubMed ID: 34506975

Doi: 10.1016/j.actbio.2021.09.004

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Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells

Authors: Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana

Journal: Nutrients

PubMed ID: 34579029

Doi: 10.3390/nu13093152

Products & Services: Proteins, Expression, Isolation and Analysis

Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Salinthip Jarusintanakorn, Chutima Phechkrajang, Putthiporn Khongkaew, Enrico Mastrobattista, Montarop Yamabhai

Journal: Anal Bioanal Chem

PubMed ID: 34476523

Doi: 10.1007/s00216-021-03549-4

Products & Services: Proteins, Expression, Isolation and Analysis

Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Authors: Brandi T Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A Granek, Cliburn Chan, Soman N Abraham, Herman F Staats

Journal: Front Immunol

PubMed ID: 34566991

Doi: 10.3389/fimmu.2021.730346

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Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Authors: Jaya Joshi, Qiang Li, Jorge D García-García, Bryan J Leong, You Hu, Steven D Bruner, Andrew D Hanson

Journal: Biochem J

PubMed ID: 34409984

Doi: 10.1042/BCJ20210565

Products & Services: Bacterial Expression

A Plant-Produced Virus-Like Particle Displaying Envelope Protein Domain III Elicits an Immune Response Against West Nile Virus in Mice

Authors: Jennifer Stander, Aleyo Chabeda, Edward P Rybicki, Ann E Meyers

Journal: Front Plant Sci

PubMed ID: 34589108

Doi: 10.3389/fpls.2021.738619

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Transcriptome Reprogramming of Tomato Orchestrate the Hormone Signaling Network of Systemic Resistance Induced by

Authors: Jagmohan Singh, Rashmi Aggarwal, Bishnu Maya Bashyal, K Darshan, Pooja Parmar, M S Saharan, Zakir Hussain, Amolkumar U Solanke

Journal: Front Plant Sci

PubMed ID: 34630468

Doi: 10.3389/fpls.2021.721193

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Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Kozeta Libohova, Jessica R Blount, Alyson L Sujkowski, Matthew V Prifti, Wei-Ling Tsou, Sokol V Todi

Journal: Neurobiol Dis

PubMed ID: 34563642

Doi: 10.1016/j.nbd.2021.105516

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Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Authors: Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan

Journal: Mol Med Rep

PubMed ID: 34558634

Doi: 10.3892/mmr.2021.12458

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Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE

Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda

Journal: Immun Inflamm Dis

PubMed ID: 34533288

Doi: 10.1002/iid3.531

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Precise Characterization of Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies

Authors: Wei Lu, Xinhui Lan, Tong Zhang, Hao Sun, Sanyuan Ma, Qingyou Xia

Journal: Insects

PubMed ID: 34564273

Doi: 10.3390/insects12090832

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Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)

Authors: Nazli Sotoudeh, Zahra Noormohammadi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht, Mahdi Behdani

Journal: Iran J Basic Med Sci

PubMed ID: 35083014

Doi: 10.22038/IJBMS.2021.57774.12851

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Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Authors: Moisés Martínez Velázquez, Carla Patricia Barragán Álvarez, José Miguel Flores Fernández, Rodolfo Esteban Lagunes Quintanilla, Edgar Castro Saines, Patricia Berenice Ramírez Rodríguez, Sara Elisa Herrera Rodríguez, Rodolfo Hernández Gutiérrez, Abel Gutiérrez Ortega, Ángel H Álvarez

Journal: Parasite

PubMed ID: 34533454

Doi: 10.1051/parasite/2021064

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Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers

Authors: Theodore W Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger

Journal: Int J Infect Dis

PubMed ID: 34601142

Doi: 10.1016/j.ijid.2021.09.065

Products & Services: Proteins, Expression, Isolation and Analysis

Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

Authors: Mona Teppor, Eva Žusinaite, Liis Karo-Astover, Ailar Omler, Kai Rausalu, Valeria Lulla, Aleksei Lulla, Andres Merits

Journal: J Virol

PubMed ID: 34319778

Doi: 10.1128/JVI.00973-21

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PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Authors: Xingang Wang, Yan Zheng, Yu Wang

Journal: Clin Exp Med

PubMed ID: 34554318

Doi: 10.1007/s10238-021-00761-5

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A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie

Journal: Talanta

PubMed ID: 34635250

Doi: 10.1016/j.talanta.2021.122868

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The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial

Authors: Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J Harrison, Gareth Bond, Sarah P Blagden

Journal: Clin Cancer Res

PubMed ID: 34497073

Doi: 10.1158/1078-0432.CCR-21-1652

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Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis

Authors: Benjamin H Jenkins, Finlay Maguire, Guy Leonard, Joshua D Eaton, Steven West, Benjamin E Housden, David S Milner, Thomas A Richards

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34521754

Doi: 10.1073/pnas.2108874118

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High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells

Authors: Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F Sikorski, Aleksander Czogalla

Journal: Membranes (Basel)

PubMed ID: 34564532

Doi: 10.3390/membranes11090715

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Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration

Authors: Shumei Chia, Thomas Leung, Ivan Tan

Journal: Cell Rep

PubMed ID: 34525355

Doi: 10.1016/j.celrep.2021.109687

Products & Services: Proteins, Expression, Isolation and Analysis

Large chromosomal segment deletions by CRISPR/LbCpf1-mediated multiplex gene editing in soybean

Authors: Kaixuan Duan, Yuanyuan Cheng, Jing Ji, Chenchen Wang, Yongshu Wei, Yuanchao Wang

Journal: J Integr Plant Biol

PubMed ID: 34331750

Doi: 10.1111/jipb.13158

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Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes

Authors: Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski

Journal: PLoS ONE

PubMed ID: 34570823

Doi: 10.1371/journal.pone.0257977

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Expression, biochemical and structural characterization of high-specific-activity β-amylase from Bacillus aryabhattai GEL-09 for application in starch hydrolysis

Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen, Yue Huang

Journal: Microb Cell Fact

PubMed ID: 34537082

Doi: 10.1186/s12934-021-01649-5

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Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species

Authors: Samuel M Goodfellow, Robert A Nofchissey, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Yan Guo, Chunyan Ye, Gregory J Mertz, Kartik Chandran, Michelle Harkins, Daryl B Domman, Darrell L Dinwiddie, Steven B Bradfute

Journal: J Virol

PubMed ID: 34549977

Doi: 10.1128/JVI.01534-21

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The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Authors: Martin A Mecchia, Mariano García-Hourquet, Fidel Lozano-Elena, Ainoa Planas-Riverola, David Blasco-Escamez, Mar Marquès-Bueno, Santiago Mora-García, Ana I Caño-Delgado

Journal: Curr Biol

PubMed ID: 34529936

Doi: 10.1016/j.cub.2021.08.050

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Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors

Authors: Sangmin Lee

Journal: Biomolecules

PubMed ID: 34572577

Doi: 10.3390/biom11091364

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Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

Authors: Ryuta Baba, Kenji Oki, Celso E Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Journal: Mol Cell Endocrinol

PubMed ID: 34520814

Doi: 10.1016/j.mce.2021.111456

Products & Services: PCR Cloning and Subcloning

Phycobilin heterologous production from the Rhodophyta Porphyridium cruentum

Authors: Erika Juliana Obando Montoya, Sonia Dorion, Lucía Atehortua-Garcés, Jean Rivoal

Journal: J Biotechnol

PubMed ID: 34500003

Doi: 10.1016/j.jbiotec.2021.09.001

Products & Services: PCR Cloning and Subcloning

Genetic Diversity and Population Structure of Affecting Chickpea in Ethiopia

Authors: Gezahegne Getaneh, Tadele Tefera, Fikre Lemessa, Seid Ahmed, Tarekegn Fite, Jandouwe Villinger

Journal: J Fungi (Basel)

PubMed ID: 34682241

Doi: 10.3390/jof7100820

Products & Services: Nucleic Acid Purification & Analysis

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

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Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Authors: Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Journal: Virol Sin

PubMed ID: 34581960

Doi: 10.1007/s12250-021-00444-1

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Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant Recipients

Authors: Martina Chiarucci, Sara Paolasini, Alessandro Isidori, Barbara Guiducci, Federica Loscocco, Maria Capalbo, Giuseppe Visani

Journal: Front Oncol

PubMed ID: 34552880

Doi: 10.3389/fonc.2021.737300

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Correction to: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934

Authors: Seshi R Sompuram, Emina E Torlakovic, Nils A 't Hart, Kodela Vani, Steven A Bogen

Journal: Mod Pathol

PubMed ID: 34493826

Doi: 10.1038/s41379-021-00898-4

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Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Authors: Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura

Journal: J Cell Biol

PubMed ID: 34499080

Doi: 10.1083/jcb.202103160

Products & Services: Mammalian Expression

Seroepidemiology of Infection in the General Population of Northern China: The Jidong Community Cohort Study

Authors: Jingwei Shui, Dongjie Xie, Jianhui Zhao, Cailing Ao, Hongqing Lin, Yuanhao Liang, Haiying Wang, Yingchun Dai, Shixing Tang

Journal: Front Microbiol

PubMed ID: 34650533

Doi: 10.3389/fmicb.2021.729016

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A bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions

Authors: Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk

Journal: Sci Rep

PubMed ID: 34584201

Doi: 10.1038/s41598-021-98810-2

Products & Services: Mammalian Expression

A versatile genetic engineering toolkit for E coli based on CRISPR-prime editing

Authors: Yaojun Tong, Tue S Jørgensen, Christopher M Whitford, Tilmann Weber, Sang Yup Lee

Journal: Nat Commun

PubMed ID: 34471126

Doi: 10.1038/s41467-021-25541-3

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Valorization of lignin components into gallate by integrated biological hydroxylation, O-demethylation, and aryl side-chain oxidation

Authors: Chenggu Cai, Zhaoxian Xu, Huarong Zhou, Sitong Chen, Mingjie Jin

Journal: Sci Adv

PubMed ID: 34516898

Doi: 10.1126/sciadv.abg4585

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Oriented in situ immobilization of a functional tyrosinase on microcrystalline cellulose effectively incorporates DOPA residues in bioengineered mussel adhesive protein

Authors: Suhyeok Kim, Gaeun Bae, Mincheol Shin, Eungsu Kang, Tae Yoon Park, Yoo Seong Choi, Hyung Joon Cha

Journal: Biotechnol J

PubMed ID: 34536060

Doi: 10.1002/biot.202100216

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Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

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Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

Authors: Taylor P Light, Delphine Brun, Pablo Guardado-Calvo, Riccardo Pederzoli, Ahmed Haouz, Frank Neipel, Félix A Rey, Kalina Hristova, Marija Backovic

Journal: PLoS Biol

PubMed ID: 34499637

Doi: 10.1371/journal.pbio.3001392

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A pH-engineering regenerative DNA tetrahedron ECL biosensor for the assay of SARS-CoV-2 RdRp gene based on CRISPR/Cas12a -activity

Authors: Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie

Journal: Chem Eng J

PubMed ID: 34539224

Doi: 10.1016/j.cej.2021.132472

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Visualized Multigene Editing System for

Authors: Cen Li, Jingwen Zhou, Shengqi Rao, Guocheng Du, Song Liu

Journal: ACS Synth Biol

PubMed ID: 34555894

Doi: 10.1021/acssynbio.1c00231

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in

Authors: Jianhua Li, Fanglin Xu, Dongni Ji, Chenfei Tian, Yuwei Sun, Ishmael Mutanda, Yuhong Ren, Yong Wang

Journal: Metab Eng Commun

PubMed ID: 34631421

Doi: 10.1016/j.mec.2021.e00185

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Oral Delivery of Novel Recombinant Elicit High Protection against Pulmonary and Skin Infections

Authors: Na Pan, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 34579221

Doi: 10.3390/vaccines9090984

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Metabolic engineering of Deinococcus radiodurans for pinene production from glycerol

Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar, Ivan Mijakovic

Journal: Microb Cell Fact

PubMed ID: 34565367

Doi: 10.1186/s12934-021-01674-4

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COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Authors: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arriga, Abraham Nyska, Pietro Di Lucia, Davide Marotta, Elisa Bono, Leonardo Giustini, Eleonora Sala, Chiara Perucchini, Jemma Paterson, Kathryn Ann Ryan, Amy-Rose Challis, Giulia Matusali, Francesca Colavita, Gianfranco Caselli, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Lorena Donnici, Matteo Conti, Raffaele De Francesco, Mirela Kuka, Gennaro Ciliberto, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Luca G Guidotti, Lucio Rovati, Matteo Iannacone, Luigi Aurisicchio

Journal: Mol Ther

PubMed ID: 34547465

Doi: 10.1016/j.ymthe.2021.09.011

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Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications

Authors: Ah-Young Song, Hyori Kim, Jung Min Kim, Sang-Hyun Hwang, Dae-Hyun Ko, Hun Sik Kim

Journal: ACS Appl Mater Interfaces

PubMed ID: 34486371

Doi: 10.1021/acsami.1c08986

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

Authors: Maria Y Sachkova, Eva-Lena Nordmann, Joan J Soto-Àngel, Yasmin Meeda, Bartłomiej Górski, Benjamin Naumann, Daniel Dondorp, Marios Chatzigeorgiou, Maike Kittelmann, Pawel Burkhardt

Journal: Curr Biol

PubMed ID: 34587474

Doi: 10.1016/j.cub.2021.09.005

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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T Lee, Sizun Jiang, Matthias S Matter, Carol H Yan, Jonathan B Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M Schürch, Pauline Chu, Han Chen, Anna K Stalder, David R McIlwain, Nicole A Borchard, Phillip A Gall, Sachi S Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M Duran, Kirsten D Mertz, Peter H Hwang, Jasmin D Haslbauer, Peter K Jackson, Thomas Menter, Raul Andino, Peter D Canoll, Adam S DeConde, Zara M Patel, Alexandar Tzankov, Garry P Nolan, Jayakar V Nayak

Journal: Cell Rep Med

PubMed ID: 34604819

Doi: 10.1016/j.xcrm.2021.100421

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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

Authors: Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark

Journal: Nat Commun

PubMed ID: 34489474

Doi: 10.1038/s41467-021-25570-y

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Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex

Authors: Xi Liu, Laixing Zhang, Yu Xiu, Teng Gao, Ling Huang, Yongchao Xie, Lingguang Yang, Wenhe Wang, Peiyi Wang, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nucleic Acids Res

PubMed ID: 34432044

Doi: 10.1093/nar/gkab738

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Engineering high coenzyme Q tomato

Authors: Hang Fan, Yan Liu, Chen-Yi Li, Yan Jiang, Jiao-Jiao Song, Lei Yang, Qing Zhao, Yong-Hong Hu, Xiao-Ya Chen, Jing-Jing Xu

Journal: Metab Eng

PubMed ID: 34555495

Doi: 10.1016/j.ymben.2021.09.007

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Structural and Kinetic Insights Into the Molecular Basis of Salt Tolerance of the Short-Chain Glucose-6-Phosphate Dehydrogenase From

Authors: Nicolás Fuentes-Ugarte, Sixto M Herrera, Pablo Maturana, Victor Castro-Fernandez, Victoria Guixé

Journal: Front Microbiol

PubMed ID: 34650535

Doi: 10.3389/fmicb.2021.730429

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Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells

Authors: Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa

Journal: FEBS Lett

PubMed ID: 34418081

Doi: 10.1002/1873-3468.14183

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The immunogenomic landscape of resected intrahepatic cholangiocarcinoma

Authors: Fernando Carapeto, Behnaz Bozorgui, Rachna T Shroff, Sharmeen Chagani, Luisa Solis Soto, Wai Chin Foo, Ignacio Wistuba, Funda Meric-Bernstam, Ahmed Shalaby, Milind Javle, Anil Korkut, Lawrence N Kwong

Journal: Hepatology

PubMed ID: 34510503

Doi: 10.1002/hep.32150

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CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice

Authors: Chandra N Roy, Mariana A Benitez Moreno, Chris Kline, Zandrea Ambrose

Journal: J Virol

PubMed ID: 34232063

Doi: 10.1128/JVI.00449-21

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Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Authors: Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou

Journal: Front Mol Biosci

PubMed ID: 34568426

Doi: 10.3389/fmolb.2021.720370

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Corrigendum: Reductive Power Generated by Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Authors: Thabatta L S A Rosa, Maria Angela M Marques, Zachary DeBoard, Kelly Hutchins, Carlos Adriano A Silva, Christine R Montague, Tianao Yuan, Julio J Amaral, Georgia C Atella, Patrícia S Rosa, Katherine A Mattos, Brian C VanderVen, Ramanuj Lahiri, Nicole S Sampson, Patrick J Brennan, John T Belisle, Maria Cristina V Pessolani, Marcia Berrêdo-Pinho

Journal: Front Cell Infect Microbiol

PubMed ID: 34650934

Doi: 10.3389/fcimb.2021.765326

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A Novel TLR4-Binding Domain of Peroxiredoxin From Triggers NLRP3 Inflammasome Activation in Macrophages

Authors: Xia Li, Meng Feng, Yanqing Zhao, Yuhan Zhang, Ruixue Zhou, Hang Zhou, Zhen Pang, Hiroshi Tachibana, Xunjia Cheng

Journal: Front Immunol

PubMed ID: 34659265

Doi: 10.3389/fimmu.2021.758451

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Two novel SARS-CoV-2 surrogate virus neutralization assays are suitable for assessing successful immunization with mRNA-1273

Authors: Alexander Krüttgen, Maike Lauen, Hanna Klingel, Matthias Imöhl, Michael Kleines

Journal: J Virol Methods

PubMed ID: 34563583

Doi: 10.1016/j.jviromet.2021.114297

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Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics

Authors: Yuan Zhou, Li Zhang, You-Hua Xie, Jian Wu

Journal: Lab Invest

PubMed ID: 34497366

Doi: 10.1038/s41374-021-00663-w

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Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia

Authors: Lina Abou Saleh, Abigail Boyd, Ileana V Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A Barrington, Wito Richter

Journal: FASEB J

PubMed ID: 34383981

Doi: 10.1096/fj.202100495R

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Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Authors: Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez, Simon Trowitzsch

Journal: Nat Commun

PubMed ID: 34584079

Doi: 10.1038/s41467-021-25870-3

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Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro

Authors: Gang Wang, Jun Guan, Guojun Li, Fengtian Wu, Qin Yang, Chunhong Huang, Junwei Shao, Lichen Xu, Zixuan Guo, Qihui Zhou, Haihong Zhu, Zhi Chen

Journal: Dis Markers

PubMed ID: 34603560

Doi: 10.1155/2021/6803510

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Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression

Authors: Sheng Xu, Huanhuan Tan, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Ping Zhao, Qingyou Xia, Feng Wang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34525798

Doi: 10.1021/acsami.1c08409

Products & Services: Proteins, Expression, Isolation and Analysis

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation

Authors: Lennart Pusch, Regine Brox, Karl Scheuer, Tadahiro Yokosawa, Mingjian Wu, Benjamin Apeleo Zubiri, Erdmann Spiecker, Klaus D Jandt, Dagmar Fischer, Holger Hackstein

Journal: Nanomedicine (Lond)

PubMed ID: 34523349

Doi: 10.2217/nnm-2021-0022

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Discovery of an Heparin-Binding Epidermal Growth Factor Domain Antibody from a Phage Library and Analysis of Its Inhibitory Effects in SKOV3 Cells

Authors: Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen

Journal: Cancer Biother Radiopharm

PubMed ID: 34529926

Doi: 10.1089/cbr.2021.0123

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METTL3-mediated mA RNA methylation promotes the anti-tumour immunity of natural killer cells

Authors: Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian

Journal: Nat Commun

PubMed ID: 34535671

Doi: 10.1038/s41467-021-25803-0

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Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Authors: Qiufeng Liu, Dehua Yang, Youwen Zhuang, Tristan I Croll, Xiaoqing Cai, Antao Dai, Xinheng He, Jia Duan, Wanchao Yin , Chenyu Ye, Fulai Zhou, Beili Wu, Qiang Zhao, H Eric Xu, Ming-Wei Wang, Yi Jiang

Journal: Nat Chem Biol.

PubMed ID: 34556862

Doi: 10.1038/s41589-021-00841-3

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Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity

Authors: Rosa Sottile, M Kazim Panjwani, Colleen M Lau, Anthony F Daniyan, Kento Tanaka, Juliet N Barker, Renier J Brentjens, Joseph C Sun, Jean-Benoît Le Luduec, Katharine C Hsu

Journal: Sci Immunol

PubMed ID: 34559552

Doi: 10.1126/sciimmunol.abe6968

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Combining spike- and nucleocapsid-based vaccines improves distal control of SARS-CoV-2

Authors: Tanushree Dangi, Jacob Class, Nicole Palacio, Justin M Richner, Pablo Penaloza MacMaster

Journal: Cell Rep

PubMed ID: 34450033

Doi: 10.1016/j.celrep.2021.109664

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Identification of BvgA-Dependent and BvgA-Independent Small RNAs (sRNAs) in Bordetella pertussis Using the Prokaryotic sRNA Prediction Toolkit ANNOgesic

Authors: Kyung Moon, Minji Sim, Chin-Hsien Tai, Kyungyoon Yoo, Charlotte Merzbacher, Sung-Huan Yu, David D Kim, Jaehyun Lee, Konrad U Förstner, Qing Chen, Scott Stibitz, Leslie G Knipling, Deborah M Hinton

Journal: Microbiol Spectr

PubMed ID: 34550019

Doi: 10.1128/Spectrum.00044-21

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Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Authors: Byron Shue, Abhilash I Chiramel, Berati Cerikan, Thu-Hien To, Sonja Frölich, Stephen M Pederson, Emily N Kirby, Nicholas S Eyre, Ralf F W Bartenschlager, Sonja M Best, Michael R Beard

Journal: J Virol

PubMed ID: 34586867

Doi: 10.1128/JVI.00596-21

Products & Services: Proteins, Expression, Isolation and Analysis

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

Journal: J Clin Invest

PubMed ID: 34623328

Doi: 10.1172/JCI145472

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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Authors: Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl

Journal: Elife

PubMed ID: 34486521

Doi: 10.7554/eLife.71420

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Baculovirus infection affects caterpillar chemoperception

Authors: Angel Llopis-Giménez, Gabriela Caballero-Vidal, Emmanuelle Jacquin-Joly, Cristina Maria Crava, Salvador Herrero

Journal: Insect Biochem Mol Biol

PubMed ID: 34536505

Doi: 10.1016/j.ibmb.2021.103648

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Ackr3-Venus knock-in mouse lights up brain vasculature

Authors: Aliza T Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L Kieffer

Journal: Mol Brain

PubMed ID: 34583741

Doi: 10.1186/s13041-021-00862-y

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Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Authors: Pei Dai, Zhongxiang Tang, Pinglang Ruan, Ousman Bajinka, Dan Liu, Yurong Tan

Journal: Front Oncol

PubMed ID: 34604035

Doi: 10.3389/fonc.2021.699847

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Antibody Screening Results for Anti-Nucleocapsid Antibodies Toward the Development of a Lateral Flow Assay to Detect SARS-CoV-2 Nucleocapsid Protein

Authors: David M Cate, Joshua D Bishop, Helen V Hsieh, Veronika A Glukhova, Luis F Alonzo, H Gleda Hermansky, Brianda Barrios-Lopez, Benjamin D Grant, Caitlin E Anderson, Ethan Spencer, Samantha Kuhn, Ryan Gallagher, Rafael Rivera, Crissa Bennett, Samantha A Byrnes, John T Connelly, Puneet K Dewan, David S Boyle, Bernhard H Weigl, Kevin P Nichols

Journal: ACS Omega

PubMed ID: 34608447

Doi: 10.1021/acsomega.1c01253

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Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection

Authors: Hai Li, Hu Ren, Yan Zhang, Lei Cao, Wenbo Xu

Journal: Sci Rep

PubMed ID: 34545126

Doi: 10.1038/s41598-021-97535-6

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High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population

Authors: Arshad A Pandith, Usma Manzoor, Ina Amin, Abida Ahmad, Masarat Rashid, Mahrukh H Zargar, Shayesta Rah, Fayaz A Dar, Iqbal Qasim, Dheera Sanadhya

Journal: Arch Gynecol Obstet

PubMed ID: 34542677

Doi: 10.1007/s00404-021-06235-z

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Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes

Authors: Thomas Steele, Anhao Sam, Shawna Evans, Elizabeth Browning, Sheryl Krig, Katelyn Macias, Adarsh Konda, Salma Siddiqui, Blythe Durbin-Johnson, Paramita Ghosh, Ruth Vinall

Journal: Cancers (Basel)

PubMed ID: 34503235

Doi: 10.3390/cancers13174425

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Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart

Authors: Yanbo Tang, Kevin T Kline, Xiaoying S Zhong, Ying Xiao, Haifeng Lian, Jun Peng, Xiaowei Liu, Don W Powell, Guodu Tang, Qingjie Li

Journal: PLoS ONE

PubMed ID: 34543287

Doi: 10.1371/journal.pone.0257280

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Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

Authors: Shang Yu Gong, Debashree Chatterjee, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Romain Gasser, Yuxia Bo, Dani Vézina, Guillaume Goyette, Gabrielle Gendron-Lepage, Halima Medjahed, Michel Roger, Marceline Côté, Andrés Finzi

Journal: Virology

PubMed ID: 34536797

Doi: 10.1016/j.virol.2021.09.001

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Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation

Authors: Jacquelyn R Dayton, Yinyu Yuan, Lisa P Pacumio, Bryce G Dorflinger, Samantha C Yoo, Mariah J Olson, Sara I Hernández-Suárez, Moira M McMahon, Lillian Cruz-Orengo

Journal: Front Cell Neurosci

PubMed ID: 34557075

Doi: 10.3389/fncel.2021.683687

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Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Authors: Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li

Journal: Int J Biol Macromol

PubMed ID: 34499954

Doi: 10.1016/j.ijbiomac.2021.08.232

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Genome-scale identification of () family genes and molecular characterization of their responses to diverse nutrient stresses in allotetraploid rapeseed

Authors: Ying Liu, Ying-Peng Hua, Huan Chen, Ting Zhou, Cai-Peng Yue, Jin-Yong Huang

Journal: PeerJ

PubMed ID: 34603847

Doi: 10.7717/peerj.12007

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Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

Products & Services: Proteins, Expression, Isolation and Analysis

Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Authors: John Pang, Nam Nguyen, Jens Luebeck, Laurel Ball, Andrey Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, Sayed Sadat, Paul S Mischel, Guorong Xu, Kathleen Fisch, Theresa Guo, Gabrielle Cahill, Bharat Panuganti, Vineet Bafna, Joseph Califano

Journal: Clin Cancer Res

PubMed ID: 34548317

Doi: 10.1158/1078-0432.CCR-21-2484

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A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

Authors: Juliano Alves, Laurie Engel, Renata de Vasconcelos Cabral, Eduardo L Rodrigues, Liane de Jesus Ribeiro, Luiza M Higa, Orlando da Costa Ferreira Júnior, Terezinha Marta P P Castiñeiras, Isabela de Carvalho Leitão, Amilcar Tanuri, Said A Goueli, Hicham Zegzouti

Journal: Sci Rep

PubMed ID: 34531417

Doi: 10.1038/s41598-021-97330-3

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The impact of chromophore choice on the assembly kinetics and primary photochemistry of a red/green cyanobacteriochrome

Authors:

Journal: Phys Chem Chem Phys

PubMed ID: 34374395

Doi: 10.1039/d1cp02696h

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DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Authors: Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34568799

Doi: 10.1016/j.isci.2021.103086

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