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Core-shell "loading-type" nanomaterials towards: Simultaneous imaging analysis of glutathione and microRNA

Authors: Lin-Lin Lu, Qin Zhang, Yu Gu, Xiang-Ling Li, Jing Jing Xie

Journal: Anal Chim Acta

PubMed ID: 35151402

Doi: 10.1016/j.aca.2022.339551

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Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses

Authors: Bo Wang, Shuang Li, Yongbo Qiao, Yu Fu, Jiaojiao Nie, Shun Jiang, Xin Yao, Yi Pan, Linye Zhao, Congmei Wu, Yuhua Shi, Yuhe Yin, Yaming Shan

Journal: J Nanobiotechnology

PubMed ID: 35012571

Doi: 10.1186/s12951-021-01229-0

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Self-Assembly of Flagellin into Immunostimulatory Ring-like Nanostructures as an Antigen Delivery System

Authors: Mélanie Côté-Cyr, Ximena Zottig, Laurie Gauthier, Denis Archambault, Steve Bourgault

Journal: ACS Biomater Sci Eng

PubMed ID: 35080372

Doi: 10.1021/acsbiomaterials.1c01332

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The Novel microRNA Rno-miR-686-3p Is Associated with the Ischaemic Penumbra

Authors: Wei Wang, Jin-Pin Li, Jing-Li Liu

Journal: Eur Neurol

PubMed ID: 35100587

Doi: 10.1159/000521491

Products & Services: DNA Sequencing

Production and application of mouse monoclonal antibodies targeting linear epitopes in pB602L of African swine fever virus

Authors: Pengfei Wang, Chunguo Liu, Shida Wang, Lili Wen, Zhibin Shi, Yue Chi, Ming Wang, Zaisi Liu, Zhenzhao Sun, Lili Wei, Decheng Yang, Xijun He, Jingfei Wang

Journal: Arch Virol

PubMed ID: 34984562

Doi: 10.1007/s00705-021-05335-0

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Large inter-individual variability of cellular and humoral immunological responses to mRNA-1273 (Moderna) vaccination against SARS-CoV-2 in health care workers

Authors: Alexander Krüttgen, Gerhard Haase, Helga Haefner, Matthias Imöhl, Michael Kleines

Journal: Clin Exp Vaccine Res

PubMed ID: 35223670

Doi: 10.7774/cevr.2022.11.1.96

Protocol for structure determination of SARS-CoV-2 main protease at near-physiological-temperature by serial femtosecond crystallography

Authors: Fatma Betul Ertem, Omur Guven, Cengizhan Buyukdag, Oktay Gocenler, Esra Ayan, Busra Yuksel, Mehmet Gul, Gozde Usta, Barıs Cakılkaya, J Austin Johnson, E Han Dao, Zhen Su, Frederic Poitevin, Chun Hong Yoon, Christopher Kupitz, Brandon Hayes, Mengning Liang, Mark S Hunter, Alexander Batyuk, Raymond G Sierra, Gihan Ketawala, Sabine Botha, Çağdaş Dağ, Hasan DeMirci

Journal: STAR Protoc

PubMed ID: 35194584

Doi: 10.1016/j.xpro.2022.101158

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CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA

Authors: Simin Chen, Zhaoyu Zhang, Baoxin Zhang, Qing Huang, Yi Liu, Yi Qiu, Xinmiao Long, Minghua Wu, Zuping Zhang

Journal: Int J Biol Sci

PubMed ID: 35002529

Doi: 10.7150/ijbs.66114

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Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue

Authors: Yingzi Tan, Miao Wang, Yijun Chen

Journal: ACS Synth Biol

PubMed ID: 35006674

Doi: 10.1021/acssynbio.1c00578

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An endogenous bornavirus-like nucleoprotein in miniopterid bats retains the RNA-binding properties of the original viral protein

Authors: Yahiro Mukai, Masayuki Horie, Shohei Kojima, Junna Kawasaki, Ken Maeda, Keizo Tomonaga

Journal: FEBS Lett

PubMed ID: 35043395

Doi: 10.1002/1873-3468.14290

Products & Services: Recombinant Antibody Expression

The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate

Authors: Aishwarya Srivastava, Pragya Nagar, Sumit Rathore, Nidhi Adlakha

Journal: Microbiol Spectr

PubMed ID: 35080440

Doi: 10.1128/spectrum.02697-21

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Modified Sawhorse Waveform for the Voltammetric Detection of Oxytocin

Authors: Favian A Liu, Negar Ardabili, Izaiah Brown, Harmain Rafi, Clarice Cook, Rodanthi Nikopoulou, Arianna Lopez, Shouzhong Zou, Matthew R Hartings, Alexander G Zestos

Journal: J Electrochem Soc

PubMed ID: 35185166

Doi: 10.1149/1945-7111/ac4aae

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Active immunization combined with cisplatin confers enhanced therapeutic protection and prevents relapses of HPV-induced tumors at different anatomical sites

Authors: Bruna Felício Milazzotto Maldonado Porchia, Luana Raposo de Melo Moraes Aps, Ana Carolina Ramos Moreno, Jamile Ramos da Silva, Mariângela de Oliveira Silva, Natiely Silva Sales, Rubens Prince Dos Santos Alves, Clarissa Ribeiro Reily Rocha, Matheus Molina Silva, Karine Bitencourt Rodrigues, Tácita Borges Barros, Roberta Liberato Pagni, Patrícia da Cruz Souza, Mariana de Oliveira Diniz, Luís Carlos de Souza Ferreira

Journal: Int J Biol Sci

PubMed ID: 34975315

Doi: 10.7150/ijbs.56644

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Anion binding to a cationic europium(III) probe enables the first real-time assay of heparan sulfotransferase activity

Authors: Simon Wheeler, Colum Breen, Yong Li, Sarah H Hewitt, Erin Robertson, Edwin A Yates, Igor L Barsukov, David G Fernig, Stephen J Butler

Journal: Org Biomol Chem

PubMed ID: 34951618

Doi: 10.1039/d1ob02071d

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Targeted deletion of liver-expressed Choriogenin L results in the production of soft eggs and infertility in medaka, Oryzias latipes

Authors: Kenji Murata, Masato Kinoshita

Journal: Zoological Lett

PubMed ID: 34983666

Doi: 10.1186/s40851-021-00185-9

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Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway

Authors: Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentini

Journal: Mol Neurobiol

PubMed ID: 35044626

Doi: 10.1007/s12035-022-02748-z

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miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7

Authors: Xibao Shi, Yuanhao Yang, Xiaozhuan Zhang, Xiaobo Chang, Jing Chen, Chao Wang, Aiping Wang, Jianhua Wang, Jianru Qin, Xianlong Ye, Wei Jin, Gaiping Zhang

Journal: Viruses

PubMed ID: 35062330

Doi: 10.3390/v14010126

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Expression of phenylalanine ammonia lyases in Synechocystis sp PCC 6803 and subsequent improvements of sustainable production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 35012528

Doi: 10.1186/s12934-021-01735-8

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Multiplex genome editing of mammalian cells for producing recombinant heparin

Authors: Bryan E Thacker, Kristen J Thorne, Colin Cartwright, Jeeyoung Park, Kimberly Glass, Annie Chea, Benjamin P Kellman, Nathan E Lewis, Zhenping Wang, Anna Di Nardo, Susan T Sharfstein, Walter Jeske, Jeanine Walenga, John Hogwood, Elaine Gray, Barbara Mulloy, Jeffrey D Esko, Charles A Glass

Journal: Metab Eng

PubMed ID: 35038554

Doi: 10.1016/j.ymben.2022.01.002

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Multiplex genome editing of mammalian cells for producing recombinant heparin

Journal: Metab Eng

PubMed ID: 35038554

Doi: 10.1016/j.ymben.2022.01.002

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Genome-wide analysis and transcriptional reprogrammings of MYB superfamily revealed positive insights into abiotic stress responses and anthocyanin accumulation in Carthamus tinctorius L

Authors: Yingqi Hong, Naveed Ahmad, Jianyi Zhang, Yanxi Lv, Xinyue Zhang, Xintong Ma, Liu Xiuming, Yao Na

Journal: Mol Genet Genomics

PubMed ID: 34978004

Doi: 10.1007/s00438-021-01839-1

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Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells

Authors: Lina Lin, Liman Wang

Journal: Mol Med Rep

PubMed ID: 35014677

Doi: 10.3892/mmr.2022.12589

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Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

Authors: Sanjib K Mukherjee, Jim-Marcel Knop, Roland Winter

Journal: Chemistry

PubMed ID: 34882862

Doi: 10.1002/chem.202104182

Products & Services: Mammalian Expression

A model for DHX15 mediated disassembly of A-complex spliceosomes

Authors: Hannah M Maul-Newby, Angela N Amorello, Turvi Sharma, John H Kim, Matthew S Modena, Beth E Prichard, Melissa S Jurica

Journal: RNA

PubMed ID: 35046126

Doi: 10.1261/rna.078977.121

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Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Authors: Rhia Kundu, Janakan Sam Narean, Lulu Wang, Joseph Fenn, Timesh Pillay, Nieves Derqui Fernandez, Emily Conibear, Aleksandra Koycheva, Megan Davies, Mica Tolosa-Wright, Seran Hakki, Robert Varro, Eimear McDermott, Sarah Hammett, Jessica Cutajar, Ryan S Thwaites, Eleanor Parker, Carolina Rosadas, Myra McClure, Richard Tedder, Graham P Taylor, Jake Dunning, Ajit Lalvani

Journal: Nat Commun

PubMed ID: 35013199

Doi: 10.1038/s41467-021-27674-x

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An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine

Authors: Bo Wu, Zehua Li, Zepeng Kang, Chunling Ma, Haiyan Song, Fuping Lu, Zhiguang Zhu

Journal: Biosensors (Basel)

PubMed ID: 35200327

Doi: 10.3390/bios12020066

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Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Authors: Jia-Wei Yang, Yu-Rou Lin, Ying-Ling Chu, Johnson H Y Chung, Huai-En Lu, Guan-Yu Chen

Journal: Commun Biol

PubMed ID: 35046486

Doi: 10.1038/s42003-022-03026-3

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CD8 T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2

Authors: Congling Qiu, Chanchan Xiao, Zhigang Wang, Guodong Zhu, Lipeng Mao, Xiongfei Chen, Lijuan Gao, Jieping Deng, Jun Su, Huanxing Su, Evandro Fei Fang, Zhang-Jin Zhang, Jikai Zhang, Caojun Xie, Jun Yuan, Oscar Junhong Luo, Li An Huang, Pengcheng Wang, Guobing Chen

Journal: Front Immunol

PubMed ID: 35116022

Doi: 10.3389/fimmu.2021.764949

Products & Services: Peptide Synthesis

Optimization of Protoplast Isolation and Transformation for a Pilot Study of Genome Editing in Peanut by Targeting the Allergen Gene

Authors: Sudip Biswas, Nancy J Wahl, Michael J Thomson, John M Cason, Bill F McCutchen, Endang M Septiningsih

Journal: Int J Mol Sci

PubMed ID: 35055026

Doi: 10.3390/ijms23020837

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Identification of a plant endophytic growth-promoting bacteria capable of inhibiting cadmium uptake in rice

Authors: Wei Tian, Le Li, Xiao Xiao, Huili Wu, Yulong Wang, Zhaoyang Hu, Nahmina Begum, Yiping Zou, Laiqing Lou, Ming Chang, Qingsheng Cai

Journal: J Appl Microbiol

PubMed ID: 34216530

Doi: 10.1111/jam.15201

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Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

Authors: Grega Popovic, Nicholas C Kirby, Taylor C Dement, Kristine M Peterson, Caroline E Daub, Heather A Belcher, Martin Guthold, Adam R Offenbacher, Nathan E Hudson

Journal: Int J Mol Sci

PubMed ID: 35162976

Doi: 10.3390/ijms23031054

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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Authors: Enquan Xu, Ravindra Boddu, Hisham A Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M Carlisle, Elliot J Lefkowitz, Ashley S Harms, Etty N Benveniste, Talene A Yacoubian, Laura A Volpicelli-Daley, David G Standaert, Andrew B West

Journal: Mol Neurodegener

PubMed ID: 35012605

Doi: 10.1186/s13024-021-00509-5

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Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

Authors: Kylie M Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Himanshi Chawla, Jianqiu Du, Nicholas J Tursi, Alan Moore, Jared Adolf-Bryfogle, Mansi Purwar, Emma L Reuschel, Drew Frase, Matthew Sullivan, Benjamin Fry, Igor Maricic, Viviane M Andrade, Christel Iffland, Max Crispin, Kate E Broderick, Laurent M P F Humeau, Ami Patel, Trevor R F Smith, Jesper Pallesen, David B Weiner, Daniel W Kulp

Journal: Cell Rep

PubMed ID: 35090597

Doi: 10.1016/j.celrep.2022.110318

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Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection

Authors: Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D Tapia, J Kristie Johnson, Samba O Sow, Joshua T Thaden, Vance G Fowler, Karen A Krogfelt, Annelie Brauner, Efthymia Protonotariou, Eirini Christaki, Yuichiro Shindo, Andrea L Kwa, Sadia Shakoor, Ashika Singh-Moodley, Olga Perovic, Jan Jacobs, Octavie Lunguya, Raphael Simon, Alan S Cross, Sharon M Tennant

Journal: BMC Microbiol

PubMed ID: 34991476

Doi: 10.1186/s12866-021-02427-4

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Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria

Authors: Karol M Córdoba, Irantzu Serrano-Mendioroz, Daniel Jericó, María Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, María J Garrido, Paolo G V Martini, José Luis Lanciego, Jesús Prieto, Pedro Berraondo, Antonio Fontanellas

Journal: Sci Transl Med

PubMed ID: 35020410

Doi: 10.1126/scitranslmed.abc0700

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Physicochemical Characterization and In Vitro Digestibility Study of an In Silico Designed Recombinant Protein Enriched with Large Neutral Amino Acids and Lacking Phenylalanine for Phenylketonuria

Authors: Prakruthi Appaiah, L Sunil, Asha Martin, Prasanna Vasu

Journal: Protein J

PubMed ID: 35064867

Doi: 10.1007/s10930-021-10039-0

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Enzymatic synthesis of cellulose in space: gravity is a crucial factor for building cellulose II gel structure

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: Cellulose (Lond)

PubMed ID: 35125685

Doi: 10.1007/s10570-021-04399-0

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Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor

Authors: Longying Jiang, Xueke Liu, Hudie Wei, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Yongheng Chen

Journal: Biochem Biophys Res Commun

PubMed ID: 35091108

Doi: 10.1016/j.bbrc.2022.01.069

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Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Authors: Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B Weiner, Kate Broderick, Bin Wang

Journal: Hum Vaccin Immunother

PubMed ID: 35061975

Doi: 10.1080/21645515.2021.2016201

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Discovery of Fragment-Based Inhibitors of SARS-CoV 2 PL Pro

Authors: Qiangqiang Wei; Ashley J. Taylor; Mahesh Angadrao Barmade; Kevin B. Teuscher; Somanath Chowdhury; Chideraa Apakama; Jordan Anderson-Daniels; Zhu Yongqing; David C. Schultz; Tyson A. Rietz; Taylor M. South; Mackenzie M. Crow; Bin Zhao; Kangsa Amporndanai; John L. Sensintaffar; Jason Phan; Sara Cherry; Mark Denison; Taekyu Lee; Stephen W. Fesik

Journal: Journal of Medicinal Chemistry

PubMed ID: 41521555

Doi: 10.1021/acs.jmedchem.5c02832

Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice

Authors: Anny Treat, Vianie Henri, Junke Liu, Joyce Shen, Mauricio Gil-Silva, Alejandro Morales, Avaneesh Rade, Kevin Joseph Tidgewell, Benedict Kolber, Young Shen

Journal: ACS Omega

PubMed ID: 35097287

Doi: 10.1021/acsomega.1c05727

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Peroxisomal ATP Uptake Is Provided by Two Adenine Nucleotide Transporters and the ABCD Transporters

Authors: Carlo W T van Roermund, Lodewijk IJlst, Nicole Linka, Ronald J A Wanders, Hans R Waterham

Journal: Front Cell Dev Biol

PubMed ID: 35127709

Doi: 10.3389/fcell.2021.788921

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Azole-Resistant Alleles of in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors

Authors: Bao Gia Vu, W Scott Moye-Rowley

Journal: Antimicrob Agents Chemother

PubMed ID: 35007132

Doi: 10.1128/AAC.02098-21

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Three-repeat and four-repeat tau isoforms form different oligomers

Authors: Hedieh Shahpasand-Kroner, Jennifer Portillo, Carter Lantz, Paul M Seidler, Natalie Sarafian, Joseph A Loo, Gal Bitan

Journal: Protein Sci

PubMed ID: 34902187

Doi: 10.1002/pro.4257

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FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape

Authors: Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li

Journal: Theranostics

PubMed ID: 34976216

Doi: 10.7150/thno.66575

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Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression

Authors: Cláudia Martins-Lima, Vera Miranda-Gonçalves, João Lobo, Vera Constâncio, Pedro Leite-Silva, Catarina Guimarães-Teixeira, Sara Monteiro-Reis, José Pedro Sequeira, Mariana Cantante, Céline S Gonçalves, Bruno M Costa, Rui Henrique, Carmen Jerónimo

Journal: Cell Oncol (Dordr)

PubMed ID: 35064910

Doi: 10.1007/s13402-021-00657-2

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A Novel Peptide Derived from Induces Apoptosis in Colorectal Cancer Cells through Mitochondria and the p38 MAPK Pathway

Authors: Chunlei Li, Sirui Zhang, Jianhua Zhu, Weijuan Huang, Yuanyuan Luo, Hui Shi, Dongbo Yu, Liguo Chen, Liyan Song, Rongmin Yu

Journal: Mar Drugs

PubMed ID: 35200639

Doi: 10.3390/md20020110

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Channelopathy-causing mutations in the SA/SB and HA/HB helices of K23 and K31 channels alter their apparent Ca sensitivity

Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang

Journal: Cell Calcium

PubMed ID: 35030515

Doi: 10.1016/j.ceca.2022.102538

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Mapping Critical Residues in ATG11's Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy

Authors: Mitchell D Meyer, Jasmine Winzeler, Sophia M Taylor, Alex Kilgore, Kimberly Edicha, Chase Chitwood, Zachary Spearin, S K Nadia Rahman Silvia, Ronith Chakraborty, Jesse E Smith, Bridget Kennedy, Carson Zois, Hayley Cawthon, Mukiri Gilruth, Steven K Backues

Journal: Front Cell Dev Biol

PubMed ID: 35118068

Doi: 10.3389/fcell.2021.775364

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Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens

Authors: Xiahui Chen, Shoukai Kang, Md Ashif Ikbal, Zhi Zhao, Yuxin Pan, Jiawei Zuo, Liangcai Gu, Chao Wang

Journal: Biosens Bioelectron

PubMed ID: 35051851

Doi: 10.1016/j.bios.2022.113971

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Development and Evaluation of a Molecular Hepatitis A Virus Assay for Serum and Stool Specimens

Authors: Robert A Kozak, Candace Rutherford, Melissa Richard-Greenblatt, N Y Elizabeth Chau, Ana Cabrera, Mia Biondi, Jamie Borlang, Jaqueline Day, Carla Osiowy, Sumathi Ramachandran, Nancy Mayer, Laurel Glaser, Marek Smieja

Journal: Viruses

PubMed ID: 35062362

Doi: 10.3390/v14010159

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Differential T cell immune responses to deamidated adeno-associated virus vector

Authors: So Jin Bing, Sune Justesen, Wells W Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35211638

Doi: 10.1016/j.omtm.2022.01.005

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Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

Authors: Jing Zhao, Siyuan Gao, Yanli Guo, Qinglei Xu, Mingzheng Liu, Chunlei Zhang, Meng Cheng, Xianle Zhao, Allan P Schinckel, Bo Zhou

Journal: Biology (Basel)

PubMed ID: 35053133

Doi: 10.3390/biology11010135

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Characterization of a Novel Chimeric p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice

Authors: Leah Whittle, Ros Chapman, Michiel van Diepen, Edward P Rybicki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 35214669

Doi: 10.3390/vaccines10020210

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Performance of the cobas® HBV RNA automated investigational assay for the detection and quantification of circulating HBV RNA in chronic HBV patients

Authors: Caroline Scholtès, Aaron T Hamilton, Marie-Laure Plissonnier, Caroline Charre, Beth Scott, Ling Wang, Françoise Berby, Janine French, Barbara Testoni, Alan Blair, Miroslava Subic, Matthias Hoppler, Andreas Lankenau, Andreas Grubenmann, Massimo Levrero, Marintha L Heil, Fabien Zoulim

Journal: J Clin Virol

PubMed ID: 35427860

Doi: 10.1016/j.jcv.2022.105150

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Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system

Authors: Zhuang Zhuang Han; Sang-Gyun Kang; Erik Gomez-Cardona; Serene Wohlgemuth; Klinton Shmeit; Luis Arce; Jiri G. Safar; Olivier Julien; David Westaway

Journal: Geroscience

PubMed ID: 40660080

Doi: 10.1007/s11357-025-01737-z

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Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction

Authors: Yafen Wang, Xiangnan Kuang, Yujie Yin , Ningxin Han, Liping Chang, Hongtao Wang, Yunlong Hou, Huixin Li, Zhen Li , Yi Liu, Yuanjie Hao , Yaru Wei, Xiaoqi Wang, Zhenhua Jia

Journal: Biomed Pharmacother

PubMed ID: 34740097

Doi: 10.1016/j.biopha.2021.112367

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SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ

Authors: Julia V Gerasimenko , Ole H Petersen , Oleg V Gerasimenko

Journal: Function (Oxf)

Doi: 10.1093/function/zqac002

Products & Services: Recombinant Proteins

Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus

Authors: Bryce P Johnson , Vikas Kumar , Erin M Scull , Leonard M Thomas , Christina R Bourne , Shanteri Singh

Journal: ACS Chem Biol

PubMed ID: 34905349

Doi: 10.1021/acschembio.1c00655

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Functionality of a bicistronic construction containing and genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

Authors: Alisa A Shaimardanova, Daria S Chulpanova, Valeriya V Solovyeva, Aleksandr M Aimaletdinov, Albert A Rizvanov

Journal: Neural Regen Res

PubMed ID: 34100447

Doi: 10.4103/1673-5374.314310

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CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy

Authors: Dan Wang, Ling Chen, Chengbi Li, Quanxin Long, Qing Yang, Ailong Huang, Hua Tang

Journal: J Nanobiotechnology

PubMed ID: 34991617

Doi: 10.1186/s12951-021-01233-4

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Deletion of Specific Conserved Motifs from the N-Terminal Domain of B-Crystallin Results in the Activation of Chaperone Functions

Authors: Sundararajan Mahalingam Goutham Shankar, Brian P. Mooney, Kamal Singh, Puttur Santhoshkumar, and Krishna K. Sharma

Journal: International Journal of Molecular Sciences

Doi: 10.3390/ijms23031099

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Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase

Authors: Chia Wei Hsu, Mark L Sowers, Tuvshintugs Baljinnyam, Jason L Herring, Linda C Hackfeld, Hui Tang, Kangling Zhang, Lawrence C Sowers

Journal: J Biol Chem

PubMed ID: 35085553

Doi: 10.1016/j.jbc.2022.101638

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Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection

Authors: Bojie Xu , Ruicheng Yang , Bo Yang , Liang Li , Jiaqi Chen , Jiyang Fu , Xinyi Qu , Dong Huo , Chen Tan , Huanchun Chen , Zhong Peng , Xiangru Wang

Journal: Mol Brain

PubMed ID: 34980188

Doi: 10.1186/s13041-021-00890-8

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Efficient Amber Suppression Ribosomal Skipping for Synthesis of Photoconditional Nanobodies

Authors: Eike F Joest, Christian Winter, Joshua S Wesalo, Alexander Deiters, Robert Tampé

Journal: ACS Synth Biol

PubMed ID: 35060375

Doi: 10.1021/acssynbio.1c00471

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Protein Phosphatase 2A Deficiency in Macrophages Increases Foam Cell Formation and Accelerates Atherosclerotic Lesion Development

Authors: Rui Li, Chao Zhang, Fei Xie, Xianming Zhou, Xingjian Hu, Jiawei Shi, Xinling Du, Zhiyong Lin, Nianguo Dong

Journal: Front Cardiovasc Med

PubMed ID: 35118139

Doi: 10.3389/fcvm.2021.745009

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Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

Authors: Le Thi My Le, James Robert Thompson, Phuoc Xuan Dang, Janarjan Bhandari, Amer Alam

Journal: Commun Biol

PubMed ID: 35013584

Doi: 10.1038/s42003-021-02970-w

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T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Authors: Roanne Keeton, Marius B Tincho, Amkele Ngomti, Richard Baguma, Ntombi Benede, Akiko Suzuki, Khadija Khan, Sandile Cele, Mallory Bernstein, Farina Karim, Sharon V Madzorera, Thandeka Moyo-Gwete, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Daniel Mutithu, Olukayode Aremu, Cari Stek, Elsa du Bruyn, Mieke A Van Der Mescht, Zelda de Beer, Talita R de Villiers, Annie Bodenstein, Gretha van den Berg, Adriano Mendes, Amy Strydom, Marietjie Venter, Jennifer Giandhari, Yeshnee Naidoo, Sureshnee Pillay, Houriiyah Tegally, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Robert J Wilkinson, Tulio de Oliveira, Linda-Gail Bekker, Glenda Gray, Veronica Ueckermann, Theresa Rossouw, Michael T Boswell, Jinal N Bhiman, Penny L Moore, Alex Sigal, Ntobeko A B Ntusi, Wendy A Burgers, Catherine Riou

Journal: Nature

PubMed ID: 35102311

Doi: 10.1038/s41586-022-04460-3

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Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate

Authors: Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang

Journal: PLoS Pathog

PubMed ID: 35073369

Doi: 10.1371/journal.ppat.1010253

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Engineered human antibodies for the opsonization and killing of

Authors: Xinhai Chen, Olaf Schneewind, Dominique Missiakas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35058363

Doi: 10.1073/pnas.2114478119

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Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells

Authors: Lin Yang, Xiaohua Liu, Liying Zhang, Xue Li, Xinwei Zhang, Guoyu Niu, Weilong Ji, Si Chen, Hongsheng Ouyang, Linzhu Ren

Journal: Viruses

PubMed ID: 35062360

Doi: 10.3390/v14010156

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Targeted gene silencing in the nervous system with CRISPR-Cas13

Authors: Jackson E Powell, Colin K W Lim, Ramya Krishnan, Tristan X McCallister, Christian Saporito-Magriña, Maria A Zeballos, Garrett D McPheron, Thomas Gaj

Journal: Sci Adv

PubMed ID: 35044815

Doi: 10.1126/sciadv.abk2485

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Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants

Authors: Anna Goc, Aleksandra Niedzwiecki, Vadim Ivanov, Svetlana Ivanova, Matthias Rath

Journal: Eur J Microbiol Immunol (Bp)

PubMed ID: 35060921

Doi: 10.1556/1886.2021.00022

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High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

Authors: Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M Standley, Tatsusada Okuno, Hideki Mochizuki

Journal: Sci Rep

PubMed ID: 34997058

Doi: 10.1038/s41598-021-04074-1

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The temporal gene expression profiles of calcium and phosphorus transporters in Hy-Line Brown layers

Authors: Xiaojuan Wang, Peng Li, Jingpeng Zhao, Hongchao Jiao, Hai Lin

Journal: Poult Sci

PubMed ID: 35202896

Doi: 10.1016/j.psj.2022.101736

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SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy

Authors: Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao, Zheng Zhang

Journal: J Immunol

PubMed ID: 34996837

Doi: 10.4049/jimmunol.2100684

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Identification of sequence-specific promoters driving polycistronic transcription initiation by RNA polymerase II in trypanosomes

Authors: Carlos Cordon-Obras, Claudia Gomez-Liñan, Sara Torres-Rusillo, Isabel Vidal-Cobo, Diana Lopez-Farfan, Alicia Barroso-Del Jesus, Domingo Rojas-Barros, Mark Carrington, Miguel Navarro

Journal: Cell Rep

PubMed ID: 35021094

Doi: 10.1016/j.celrep.2021.110221

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Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance

Authors: Hyo Jung Sim, Chanmi Cho, Ha Eun Kim, Ju Yeon Hong, Eun Kyung Song, Keun Yeong Kwon, Dong Gil Jang, Seok-Jung Kim, Hyun-Shik Lee, Changwook Lee, Taejoon Kwon, Siyoung Yang, Tae Joo Park

Journal: Sci Adv

PubMed ID: 35061535

Doi: 10.1126/sciadv.abl4222

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FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity

Authors: Yun Cheng, Xiao-Zhuo Kang, Tao Cheng, Zi-Wei Ye, George L Tipoe, Cheng-Han Yu, Chi-Ming Wong, Baohua Liu, Chi-Ping Chan, Dong-Yan Jin

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 35093589

Doi: 10.1016/j.jcmgh.2022.01.017

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The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences

Authors: Douglas S MacPherson, Scott A McPhee, Brian M Zeglis, Rein V Ulijn

Journal: ACS Biomater Sci Eng

PubMed ID: 35050574

Doi: 10.1021/acsbiomaterials.1c01488

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Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody

Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Nawannaporn Sae-Lim, Porntippa Lekcharoensuk, Nitat Sookrung, Wanpen Chaicumpa

Journal: Viruses

PubMed ID: 35062329

Doi: 10.3390/v14010125

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Anticancer Vaccination with Immunogenic Micelles That Capture and Release Pristine CD8 T-Cell Epitopes and Adjuvants

Authors: He Ren, Jiexin Li, Gengqi Liu, Yaping Sun, Xingyue Yang, Zhen Jiang, Jingyu Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34986639

Doi: 10.1021/acsami.1c18117

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NanoBRET in C elegans illuminates functional receptor interactions in real time

Authors: Victoria Elisabeth Groß, Miron Mikhailowitsch Gershkovich, Torsten Schöneberg, Anette Kaiser, Simone Prömel

Journal: BMC Mol Cell Biol

PubMed ID: 35100990

Doi: 10.1186/s12860-022-00405-w

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Orthogonal proteomics methods to unravel the HOTAIR interactome

Authors: Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman

Journal: Sci Rep

PubMed ID: 35087108

Doi: 10.1038/s41598-022-05405-6

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A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

Authors: Nawal Abd El-Baky, Esmail M El-Fakharany, Soraya A Sabry, Ehab R El-Helow, Elrashdy Mustafa Redwan, Amira Sabry

Journal: Biology (Basel)

PubMed ID: 35205024

Doi: 10.3390/biology11020157

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Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering

Authors: Yile Hao, Qinhua Wang, Jie Li, Shihui Yang, Yanli Zheng, Wenfang Peng

Journal: Open Biol

PubMed ID: 35016549

Doi: 10.1098/rsob.210241

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Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

Authors: Charles A Specht, E Jane Homan, Chrono K Lee, Zhongming Mou, Christina L Gomez, Maureen M Hester, Ambily Abraham, Florentina Rus, Gary R Ostroff, Stuart M Levitz

Journal: MBio

PubMed ID: 35089095

Doi: 10.1128/mbio.03367-21

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Transcriptome analysis of Leucojum aestivum and identification of genes involved in norbelladine biosynthesis

Authors: Laurence Tousignant, Aracely Maribel Diaz-Garza, Bharat Bhusan Majhi, Sarah-Eve Gélinas, Aparna Singh, Isabel Desgagne-Penix

Journal: Planta

PubMed ID: 34981205

Doi: 10.1007/s00425-021-03741-x

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Recombinant Pap31 for the Diagnosis of Canine and Human Bartonelloses

Authors: Pradeep Neupane, Ricardo G Maggi, Manoj Basnet, Erin Lashnits, Gerard P Andrews, Edward B Breitschwerdt

Journal: Pathogens

PubMed ID: 35215127

Doi: 10.3390/pathogens11020182

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SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease

Authors: Stefania Colarusso, Federica Ferrigno, Simona Ponzi, Francesca Pavone, Immacolata Conte, Luigi Abate, Elisa Beghetto, Antonino Missineo, Jerome Amaudrut, Alberto Bresciani, Giacomo Paonessa, Licia Tomei, Christian Montalbetti, Elisabetta Bianchi, Carlo Toniatti, Jesus M Ontoria

Journal: Bioorg Med Chem

PubMed ID: 35123179

Doi: 10.1016/j.bmc.2022.116631

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Cytokines in the Immune Microenvironment Change the Glycosylation of IgG by Regulating Intracellular Glycosyltransferases

Authors: Yedi Cao, Zhijing Song, Zhendong Guo, Xue Zhao, Yan Gong, Keli Zhao, Chenxue Qu, Youyuan Huang, Yan Li, Ying Gao, Junqing Zhang, Xiaohui Guo

Journal: Front Immunol

PubMed ID: 35140700

Doi: 10.3389/fimmu.2021.724379

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Structure of the human ATM kinase and mechanism of Nbs1 binding

Authors: Christopher Warren, Nikola P Pavletich

Journal: Elife

PubMed ID: 35076389

Doi: 10.7554/eLife.74218

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Two phylogenetically unrelated peptide-receptor modules jointly regulate lateral root initiation via a partially shared signaling pathway in Arabidopsis thaliana

Authors: Joris Jourquin, Ana Ibis Fernandez, Boris Parizot, Ke Xu, Wim Grunewald, Akihito Mamiya, Hidehiro Fukaki, Tom Beeckman

Journal: New Phytol

PubMed ID: 34913488

Doi: 10.1111/nph.17919

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Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19

Authors: Mihaela Chivu-Economescu, Coralia Bleotu, Camelia Grancea, Daniela Chiriac, Anca Botezatu, Iulia V Iancu, Ioana Pitica, Laura G Necula, Ana Neagu, Lilia Matei, Denisa Dragu, Camelia Sultana, Elena L Radu, Alina Nastasie, Oana Voicu, Marius Ataman, Saviana Nedeianu, Cristina Mambet, Carmen C Diaconu, Simona Maria Ruta

Journal: J Cell Mol Med

PubMed ID: 35043552

Doi: 10.1111/jcmm.17186

The CinB Nuclease from No Is Sufficient for Induction of Cytoplasmic Incompatibility in

Authors: Guangxin Sun, Mengwen Zhang, Hongli Chen, Mark Hochstrasser

Journal: MBio

PubMed ID: 35073749

Doi: 10.1128/mbio.03177-21

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Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases

Authors: Rong Chen, Lin Zhao, Rong Gan, Zhixin Feng, Chenxi Cui, Xing Xie, Fei Hao, Zhenzhen Zhang, Li Wang, Tingting Ran, Weiwu Wang, Shuijun Zhang, Yufeng Li, Wei Zhang, Maoda Pang, Qiyan Xiong, Guoqing Shao

Journal: Front Mol Biosci

PubMed ID: 35145997

Doi: 10.3389/fmolb.2021.811106

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NCAPH promotes cell proliferation and inhibits cell apoptosis of bladder cancer cells through MEK/ERK signaling pathway

Authors: Bo Li, Qian Xiao, Liping Shan, Yongsheng Song

Journal: Cell Cycle

PubMed ID: 34974790

Doi: 10.1080/15384101.2021.2021050

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Involvement of β-cyanoalanine synthase (β-CAS) and sulfurtransferase (ST) in cyanide (CN) assimilation in rice seedlings

Authors: Yu-Xi Feng, Cheng-Zhi Li, Yu-Juan Lin, Xiao-Zhang Yu

Journal: Chemosphere

PubMed ID: 35101430

Doi: 10.1016/j.chemosphere.2022.133789

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Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

Authors: Hanna Klingel, Maike Lauen, Alexander Krüttgen, Matthias Imöhl, Michael Kleines

Journal: Clin Exp Vaccine Res

PubMed ID: 35223673

Doi: 10.7774/cevr.2022.11.1.121

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Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

Authors: Jinliang Wang, Jie Luo, Zhiyuan Wen, Xinxin Wang, Lei Shuai, Gongxun Zhong, Chong Wang, Ziruo Sun, Weiye Chen, Jinying Ge, Renqiang Liu, Xijun Wang, Zhigao Bu

Journal: MBio

PubMed ID: 35012335

Doi: 10.1128/mbio.02443-21

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