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A Thermostable Cas12b from Leverages One-pot Detection of SARS-CoV-2 Variants of Concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: medrxiv

PubMed ID: 34704101

Doi: 10.1101/2021.10.15.21265066

Products & Services: Codon Optimization

Homocysteine Inhibits Pro-Insulin Receptor Cleavage and Causes Insulin Resistance Via Protein Cysteine-Homocysteinylation

Authors: Xuan Zhang, Yuan-Yuan Qu, Lian Liu, Ya-Nan Qiao, Hao-Ran Geng, Yan Lin, Wei Xu, Jing Cao, Jian-Yuan Zhao

Journal: Cell Rep

PubMed ID: 34644569

Doi: 10.2139/ssrn.3830772

Products & Services: Goat Anti-Mouse IgG Antibody (H&L) [HRP], pAb

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang

Journal: Viruses

PubMed ID: 34834981

Doi: 10.3390/v13112175

Products & Services: Peptide Synthesis

Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

Authors: Sanket S Ponia, Shelly J Robertson, Kristin L McNally, Gayatri Subramanian, Gail L Sturdevant, Matthew Lewis, Forrest Jessop, Catherine Kendall, Dylan Gallegos, Arielle Hay, Cindi Schwartz, Rebecca Rosenke, Greg Saturday, Catherine M Bosio, Craig Martens, Sonja M Best

Journal: Cell Rep

PubMed ID: 34706234

Doi: 10.1016/j.celrep.2021.109888

Products & Services: Mammalian Expression

Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost

Authors: Tamara Davidovic, Judith Schimpf, Armin Abbassi-Nik, Richard Stockinger, Hannelore Sprenger-Mähr, Karl Lhotta, Emanuel Zitt

Journal: Kidney Int

PubMed ID: 34656642

Doi: 10.1016/j.kint.2021.10.006

Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Authors: Naiyan Lu, Xinhe Wang, Wentao Shi, Lu Bian, Xuan Zhang, Guofeng Yang, Xue Tang, Jun Wang, Yin Zou, Yuyan Weng

Journal: Nanoscale Res Lett

PubMed ID: 34637014

Doi: 10.1186/s11671-021-03610-2

Products & Services: Custom Vector Construction

In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain

Authors: Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Linnea Molander, Johannes Fuchs, Ruth H Palmer

Journal: J Mol Biol

PubMed ID: 34624297

Doi: 10.1016/j.jmb.2021.167282

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Quantifying oxidation of cellulose-associated glucuronoxylan by two lytic polysaccharide monooxygenases from

Authors: Olav A Hegnar, Heidi Østby, Dejan M Petrović, Lisbeth Olsson, Anikó Várnai, Vincent G H Eijsink

Journal: Appl Environ Microbiol

PubMed ID: 34613755

Doi: 10.1128/AEM.01652-21

Products & Services: Codon Optimization

CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Authors: Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu

Journal: Theranostics

PubMed ID: 34815788

Doi: 10.7150/thno.62187

Products & Services: Catalog Peptides

Combining an optimized mRNA template with a double purification process allows strong expression of transcribed mRNA

Authors: Sergio Linares-Fernández, Julien Moreno, Elise Lambert, Perrine Mercier-Gouy, Laetitia Vachez, Bernard Verrier, Jean-Yves Exposito

Journal: Mol Ther Nucleic Acids

PubMed ID: 34692232

Doi: 10.1016/j.omtn.2021.10.007

Products & Services: Gene Synthesis

Epitopes prediction for microcystin-LR by molecular docking

Authors: Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34717216

Doi: 10.1016/j.ecoenv.2021.112925

Products & Services: Custom Vector Construction

Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Authors: Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann

Journal: Elife

PubMed ID: 34713805

Doi: 10.7554/eLife.69832

Products & Services: Plasmid DNA Preparation

Aptamer-modified biosensors to visualize neurotransmitter flux

Authors: Charlotte Moraldo, Emilie Vuille-Dit-Bille, Bajramshahe Shkodra, Tom Kloter, Nako Nakatsuka

Journal: J Neurosci Methods

PubMed ID: 34653500

Doi: 10.1016/j.jneumeth.2021.109386

Products & Services: Stable Cell Lines

Anastrozole regulates fatty acid synthase in breast cancer

Authors: Junmei Cairns, James N Ingle, Krishna R Kalari, Matthew P Goetz, Richard M Weinshilboum, Huanyao Gao, Hu Li, Mehrab Ghanat Bari, Liewei Wang

Journal: Mol Cancer Ther

PubMed ID: 34667110

Doi: 10.1158/1535-7163.MCT-21-0509

Products & Services: Mutant Libraries

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Authors: Young-Jun Park, Anna De Marco, Tyler N Starr, Zhuoming Liu, Dora Pinto, Alexandra C Walls, Fabrizia Zatta, Samantha K Zepeda, John Bowen, Kaitlin S Sprouse, Anshu Joshi, Martina Giurdanella, Barbara Guarino, Julia Noack, Rana Abdelnabi, Shi-Yan Caroline Foo, Florian A Lempp, Fabio Benigni, Gyorgy Snell, Johan Neyts, Sean Pj Whelan, Herbert W Virgin, Jesse D Bloom, Davide Corti, Matteo Samuele Pizzuto, David Veesler

Journal: biorxiv

PubMed ID: 34671770

Doi: 10.1101/2021.10.13.464254

Products & Services: Gene Synthesis

Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

Authors: Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu

Journal: Front Cell Dev Biol

PubMed ID: 34778244

Doi: 10.3389/fcell.2021.666025

Products & Services: Gene Synthesis

Design of a synthesis-friendly hypoxia-responsive promoter for cell-based therapeutics

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Eng Life Sci

PubMed ID: 34899121

Doi: 10.1002/elsc.202100045

Products & Services: PCR Cloning and Subcloning

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

Authors: Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Journal: iScience

PubMed ID: 34825148

Doi: 10.1016/j.isci.2021.103396

Products & Services: Gene Synthesis

MYB70 modulates seed germination and root system development in

Authors: Jinpeng Wan, Ruling Wang, Ping Zhang, Liangliang Sun, Qiong Ju, Haodong Huang, Shiyou Lü, Lam-Son Tran, Jin Xu

Journal: iScience

PubMed ID: 34746697

Doi: 10.1016/j.isci.2021.103228

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Function Analysis of Resistance to Bamlanivimab by SARS-CoV-2 Variants Kappa, Delta, and Lambda

Authors: Shufeng Liu, Tien Huynh, Charles B Stauft, Tony T Wang, Binquan Luan

Journal: J Chem Inf Model

PubMed ID: 34648284

Doi: 10.1021/acs.jcim.1c01058

Products & Services: Recombinant Proteins

Effect of Cotton Leafroll Dwarf Virus on Physiological Processes and Yield of Individual Cotton Plants

Authors: Ved Parkash, Divya Bhanu Sharma, John Snider, Sudeep Bag, Phillip Roberts, Afsha Tabassum, Dalton West, Sameer Khanal, Nelson Suassuna, Peng Chee

Journal: Front Plant Sci

PubMed ID: 34659302

Doi: 10.3389/fpls.2021.734386

Products & Services: PCR and Cloning

NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Authors: Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J Ulevitch, Jiahuai Han

Journal: Sci Adv

PubMed ID: 34678072

Doi: 10.1126/sciadv.abi9471

Products & Services: PCR and Cloning

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Authors: Martijn A Langereis, Irina C Albulescu, Judith Stammen-Vogelzangs, Morindy Lambregts, Ken Stachura, Suzan Miller, Angela M Bosco-Lauth, Airn E Hartwig, Stephanie M Porter, Michelle Allen, Mark Mogler, Frank J M van Kuppeveld, Berend-Jan Bosch, Paul Vermeij, Ad de Groof, Richard A Bowen, Randy Davis, Zach Xu, Ian Tarpey

Journal: npj Vaccines

PubMed ID: 34671047

Doi: 10.1038/s41541-021-00390-9

Products & Services: Recombinant Proteins

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Authors: Marumi Ohno, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md Abdul Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida, Hirofumi Sawa, Masashi Shingai

Journal: Viruses

PubMed ID: 34834944

Doi: 10.3390/v13112137

Products & Services: Codon Optimization

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

Authors: Kevin J Forsberg, Danica T Schmidtke, Rachel Werther, Ruben V Uribe, Deanna Hausman, Morten O A Sommer, Barry L Stoddard, Brett K Kaiser, Harmit S Malik

Journal: PLoS Biol

PubMed ID: 34644300

Doi: 10.1371/journal.pbio.3001428

Products & Services: Mutant Libraries

Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation

Authors: Krishna K Sarangapani, Lori B Koch, Christian R Nelson, Charles L Asbury, Sue Biggins

Journal: J Cell Biol

PubMed ID: 34647959

Doi: 10.1083/jcb.202106130

Products & Services: GenParts™ DNA Fragments

Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia

Authors: Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palanikumar, Nair Reeshma Radhakrishnan, Mohammed Yasar M, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews

Journal: Blood Adv

PubMed ID: 34625794

Doi: 10.1182/bloodadvances.2021005300

Products & Services: PCR and Cloning

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

Authors: Katelyn Mika, Mirna Marinić, Manvendra Singh, Joanne Muter, Jan Joris Brosens, Vincent J Lynch

Journal: Elife

PubMed ID: 34623259

Doi: 10.7554/eLife.69584

Products & Services: Plasmid DNA Preparation

Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis

Authors: Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim

Journal: Front Immunol

PubMed ID: 34691014

Doi: 10.3389/fimmu.2021.646316

Products & Services: Endotoxin Detection & Removal System

The S Protein of Group B Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome

Authors: Anaamika Campeau, Satoshi Uchiyama, Concepcion Sanchez, Consuelo Sauceda, Victor Nizet, David J Gonzalez

Journal: Front Microbiol

PubMed ID: 34721327

Doi: 10.3389/fmicb.2021.729308

Products & Services: Plasmid DNA Preparation

Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

Authors: Keren Isaev, Lingyan Jiang, Shuai Wu, Christian A Lee, Valérie Watters, Victoire Fort, Ricky Tsai, Fiona J Coutinho, Samer M I Hussein, Jie Zhang, Jinsong Wu, Peter B Dirks, Daniel Schramek, Jüri Reimand

Journal: Cell Rep

PubMed ID: 34686327

Doi: 10.1016/j.celrep.2021.109873

Products & Services: PCR Cloning and Subcloning

Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

Products & Services: Peptide Synthesis

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Authors: Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L Pierri, Anna De Grassi, Niamh C Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A J O'Neill, Vittoria Infantino

Journal: Cells

PubMed ID: 34831186

Doi: 10.3390/cells10112962

Products & Services: Mutant Libraries

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Authors: Frank Kozielski, Céleste Sele, Vladimir O Talibov, Jiaqi Lou, Danni Dong, Qian Wang, Xinyue Shi, Maria Nyblom, Annika Rogstam, Tobias Krojer, Zoë Fisher, Wolfgang Knecht

Journal: RSC Chem Biol

PubMed ID: 35128408

Doi: 10.1039/d1cb00135c

Products & Services: Bacterial Expression

Effects of Distal Mutations on Ligand-Binding Affinity in Dihydrofolate Reductase

Authors: Chen-Hua Huang, Yun-Wen Chen, Tsun-Tsao Huang, Ya-Ting Kao

Journal: ACS Omega

PubMed ID: 34660967

Doi: 10.1021/acsomega.1c02995

Products & Services: Plasmid DNA Preparation

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Authors: Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Journal: Front Immunol

PubMed ID: 34745083

Doi: 10.3389/fimmu.2021.670338

Products & Services: DNA Sequencing

Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 2647 macrophages

Authors: Shan Hong, Vermont P Dia, Qixin Zhong

Journal: Int J Biol Macromol

PubMed ID: 34717976

Doi: 10.1016/j.ijbiomac.2021.10.153

Products & Services: Proteins, Expression, Isolation and Analysis

Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome

Authors: Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang

Journal: FASEB J

PubMed ID: 34516679

Doi: 10.1096/fj.202101030R

Products & Services: Proteins, Expression, Isolation and Analysis

JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance

Authors: Dongjoo You, Byung Chul Jung, Sneha Damal Villivalam, Hee-Woong Lim, Sona Kang

Journal: Diabetes

PubMed ID: 34686520

Doi: 10.2337/db21-0596

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Nep1‐like Proteins from Valsa mali Differentially Regulate Pathogen Virulence and Response to Abiotic Stresses

Authors: Jianying Liu, Jiajun Nie, Yali Chang, Lili Huang

Journal: Journal of Fungi

Doi: 10.3390/jof7100830

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Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Authors: Chenxi Li, Yanyang Zhou, Xuan Chen, Yanbing Zhang, Jingbo Hu, Cicheng Ren, Jingjing Ding, Daoyuan Jiang, Yanhua Li

Journal: Dev Comp Immunol

PubMed ID: 34626690

Doi: 10.1016/j.dci.2021.104290

Products & Services: Gene Synthesis

USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates

Authors: Thang Van Nguyen

Journal: Proc Natl Acad Sci USA

PubMed ID: 34583995

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Roles of Small Subunits of Laccase (ssPOXA3a/b) in Laccase Production by Pleurotus eryngii var. ferulae

Authors: Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding

Journal: J Agric Food Chem.

PubMed ID: 34696587

Doi: doi.org/10.1021/acs.jafc.1c04777

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

Authors: Isabel Pablos, Yoan Machado, Hugo C Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A Bell, Georgina S Butler, Peter M Grin, Quynh T Cao, Jenny P Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N Kizhakkedathu, Karen Mossman, Jeremy A Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M Overall

Journal: Cell Rep

PubMed ID: 34672947

Doi: 10.1016/j.celrep.2021.109892

Products & Services: Gene Synthesis Peptide Library Services ORF cDNA Clones/MolecularCloud

SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors: Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong

Journal: Signal Transduct Target Ther

PubMed ID: 34645784

Doi: 10.1038/s41392-021-00777-z

Products & Services: Serology SARS-Cov-2 detection kits

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Authors: Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang , Xu Li

Journal: Dev Cell

PubMed ID: 34626540

Doi: 10.1016/j.devcel.2021.09.015

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CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense

Authors: Xue-Peng Li, Guan-Yu Chen, Qiu Jin, Fang-Rui Lou, Bing-Jian Liu, Jian Zhang, Ji-Xing Feng, Tian-Tian Chen

Journal: Int J Biol Macromol

PubMed ID: 34666131

Doi: 10.1016/j.ijbiomac.2021.10.080

Products & Services: Proteins, Expression, Isolation and Analysis

Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Authors: Yan Li, Siyu Shen, Haoran Guo, Zhe Zhang, Lili Zhang, Qingran Yang, Yanhang Gao, Junqi Niu, Wei Wei

Journal: Front Microbiol

PubMed ID: 34733242

Doi: 10.3389/fmicb.2021.706241

Products & Services: Proteins, Expression, Isolation and Analysis

Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Authors: Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34628068

Doi: 10.1016/j.parint.2021.102479

Products & Services: Proteins, Expression, Isolation and Analysis

The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3 Against With No Detectable Resistance

Authors: Depeng Zhu, Fangyi Chen, Yan-Chao Chen, Hui Peng, Ke-Jian Wang

Journal: Front Cell Infect Microbiol

PubMed ID: 34676176

Doi: 10.3389/fcimb.2021.752637

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana

Authors: Tong Zhu, Xue Zhou, Jian-Long Zhang, Wei-Hao Zhang, Li-Pei Zhang, Chun-Xiang You, Paula E Jameson, Peng-Tao Ma, Shan-Li Guo

Journal: Mol Plant Pathol

PubMed ID: 34633738

Doi: 10.1111/mpp.13139

Products & Services: Proteins, Expression, Isolation and Analysis

NORHA, a novel follicular atresia-related lncRNA, promotes porcine granulosa cell apoptosis via the miR-183-96-182 cluster and FoxO1 axis

Authors: Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li

Journal: J Anim Sci Biotechnol

PubMed ID: 34615552

Doi: 10.1186/s40104-021-00626-7

Products & Services: Proteins, Expression, Isolation and Analysis

Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Authors: Poorya Sadeghi, Hessamaddin Sohrabi, Maryam Hejazi, Ali Jahanban-Esfahlan, Behzad Baradaran, Maryam Tohidast, Mir Reza Majidi, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar, Miguel de la Guardia

Journal: Trends Analyt Chem

PubMed ID: 34697511

Doi: 10.1016/j.trac.2021.116460

Products & Services: Proteins, Expression, Isolation and Analysis

Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8 T cells

Authors: Margot Miranda-Katz, John J Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John V Williams

Journal: Sci Rep

PubMed ID: 34675220

Doi: 10.1038/s41598-021-00023-0

Products & Services: Proteins, Expression, Isolation and Analysis

Arabidopsis fibrillin 1-2 subfamily exerts their functions via specific protein-protein interactions

Authors: Diego Torres-Romero, Ángeles Gómez-Zambrano, Antonio Jesús Serrato, Mariam Sahrawy, Ángel Mérida

Journal: J Exp Bot

PubMed ID: 34651644

Doi: 10.1093/jxb/erab452

Products & Services: Polyclonal Antibody Services

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Authors: Kathryn McGuckin Wuertz, Erica K Barkei, Wei-Hung Chen, Elizabeth J Martinez, Ines Lakhal-Naouar, Linda L Jagodzinski, Dominic Paquin-Proulx, Gregory D Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V Thomas, Rajeshwer S Sankhala, Agnes Hajduczki, Caroline E Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F Wood, Jeffrey W Froude, Matthew Gagne, Amy R Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J Krebs, Andrew S Pekosz, Jeffrey R Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G Lewis, Sandhya Vasan, Mehul Suthar, Victoria R Polonis, Gary R Matyas, Eli A Boritz, Daniel C Douek, Robert A Seder, Sharon P Daye, Mangala Rao, Sheila A Peel, M Gordon Joyce, Diane L Bolton, Nelson L Michael, Kayvon Modjarrad

Journal: npj Vaccines

PubMed ID: 34711815

Doi: 10.1038/s41541-021-00392-7

Products & Services: Plasmid DNA Preparation

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

Authors: Nitzan Tal, Benjamin R Morehouse, Adi Millman, Avigail Stokar-Avihail, Carmel Avraham, Taya Fedorenko, Erez Yirmiya, Ehud Herbst, Alexander Brandis, Tevie Mehlman, Yaara Oppenheimer-Shaanan, Alexander F A Keszei, Sichen Shao, Gil Amitai, Philip J Kranzusch, Rotem Sorek

Journal: Cell

PubMed ID: 34644530

Doi: 10.1016/j.cell.2021.09.031

Products & Services: Plasmid DNA Preparation

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Authors: Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton

Journal: Nat Commun

PubMed ID: 34663813

Doi: 10.1038/s41467-021-26239-2

Products & Services: Plasmid DNA Preparation

Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

Authors: Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang

Journal: npj Vaccines

PubMed ID: 34611173

Doi: 10.1038/s41541-021-00382-9

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Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ()

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S Hayward, Paul D Ling

Journal: Microbiol Spectr

PubMed ID: 34668724

Doi: 10.1128/Spectrum.00983-21

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Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants in PDZ Domains Using Human PDZ Data

Authors: Haley A Wofford, Josh Myers-Dean, Brandon A Vogel, Kevin Alexander Estrada Alamo, Frederick A Longshore-Neate, Filip Jagodzinski, Jeanine F Amacher

Journal: Molecules

PubMed ID: 34641578

Doi: 10.3390/molecules26196034

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Genome Editing of Rice Loci Confers Partial Resistance to Rice Black-Streaked Dwarf Virus

Authors: Wei Wang, Shuhui Ma, Peng Hu, Yinghua Ji, Feng Sun

Journal: Viruses

PubMed ID: 34696530

Doi: 10.3390/v13102100

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LncRNA DUXAP10 Upregulation and the Hedgehog Pathway Activation Are Critically Involved in Chronic Cadmium Exposure-Induced Cancer Stem Cell-Like Property

Authors: Hsuan-Pei Lin, Zhishan Wang, Chengfeng Yang

Journal: Toxicol Sci

PubMed ID: 34373904

Doi: 10.1093/toxsci/kfab099

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Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins

Authors: Feiyue Cheng, Rui Wang, Haiying Yu, Chao Liu, Jun Yang, Hua Xiang, Ming Li

Journal: Nucleic Acids Res

PubMed ID: 34551428

Doi: 10.1093/nar/gkab821

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The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress

Authors: Jun Tian, Yaojun Wang, Ming Ding, Yue Zhang, Jiaoni Chi, Tao Wang, Bin Jiao, Zhe Jian, Xiuli Yi, Ye Huang, Ling Liu, Kai Li, Jiaxi Chen, Gang Wang, Tianwen Gao, Chunying Li, Qiang Li

Journal: Oxid Med Cell Longev

PubMed ID: 34745423

Doi: 10.1155/2021/7617839

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Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

Authors: Hüsün Sheyma Kizilkaya, Kimmie Vestergaard Sørensen, Camilla J Kibsgaard, Laerke Smidt Gasbjerg, Alexander S Hauser, Alexander Hovard Sparre-Ulrich, Niels Grarup, Mette M Rosenkilde

Journal: Front Cell Dev Biol

PubMed ID: 34760890

Doi: 10.3389/fcell.2021.749607

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Turnover of diacylglycerol kinase 4 by cytoplasmic acidification induces vacuole morphological change and nuclear DNA degradation in the early stage of pear self-incompatibility response

Authors: Xiao-Xiong Kong, Jia-Wei Mei, Jing Zhang, Xiao Liu, Ju-You Wu, Chun-Lei Wang

Journal: J Integr Plant Biol

PubMed ID: 34655280

Doi: 10.1111/jipb.13180

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Genome-wide analysis of the maize superoxide dismutase (SOD) gene family reveals important roles in drought and salt responses

Authors: Jing Liu, Lijuan Xu, Jian Shang, Xiaolin Hu, Haitao Yu, Hongying Wu, Wenben Lv, Yang Zhao

Journal: Genet Mol Biol

PubMed ID: 34606562

Doi: 10.1590/1678-4685-GMB-2021-0035

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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Authors: Su-Jeong Kim, Anjali Devgan, Brendan Miller, Sam Mool Lee, Hiroshi Kumagai, Kenneth A Wilson, Gabriella Wassef, Richard Wong, Hemal H Mehta, Pinchas Cohen, Kelvin Yen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34624450

Doi: 10.1016/j.bbagen.2021.130017

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Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides

Authors: Matevž Rumpret, Helen J von Richthofen, Maarten van der Linden, Geertje H A Westerlaken, Cami Talavera Ormeño, Jos A G van Strijp, Meytal Landau, Huib Ovaa, Nina M van Sorge, Linde Meyaard

Journal: FASEB J

PubMed ID: 34533845

Doi: 10.1096/fj.202100812R

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fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling During Seed Germination and Seedling Development

Authors: Lin Liang, Qi Wang, Zihao Song, Yaxin Wu, Qing Liang, Qingsong Wang, Jinli Yang, Ying Bi, Wen Zhou, Liu-Min Fan

Journal: Front Plant Sci

PubMed ID: 34712252

Doi: 10.3389/fpls.2021.724144

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A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons

Authors: Blaise M Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N Bledsoe, Bryanna N Vacca, Tullia V Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G Klein

Journal: Pharmacol Res Perspect

PubMed ID: 34476911

Doi: 10.1002/prp2.859

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Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication

Authors: Charlotte Flory, Kitti Wing Ki Chan, Amanda Makha Bifani, Milly Ming Ju Choy, Julien Lescar, Eng Eong Ooi, Norbert Tautz, Subhash G Vasudevan

Journal: Antiviral Res

PubMed ID: 34699863

Doi: 10.1016/j.antiviral.2021.105194

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The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni

Authors: Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie

Journal: Nucleic Acids Res

PubMed ID: 34551436

Doi: 10.1093/nar/gkab818

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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Authors: Peter J Chen, Jeffrey A Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W Nelson, Gregory A Newby, Mustafa Sahin, Mark J Osborn, Jonathan S Weissman, Britt Adamson, David R Liu

Journal: Cell

PubMed ID: 34653350

Doi: 10.1016/j.cell.2021.09.018

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Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway

Authors: Haoming Wu, Yang Wang, Qianqian Yao, Linlin Fan, Lu Meng, Nan Zheng, Huiying Li, Jiaqi Wang

Journal: Int Immunopharmacol

PubMed ID: 34634739

Doi: 10.1016/j.intimp.2021.108149

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Incorporating health co-benefits into technology pathways to achieve China's 2060 carbon neutrality goal: a modelling study

Authors: Shihui Zhang, Kangxin An, Jin Li, Yuwei Weng, Shaohui Zhang, Shuxiao Wang, Wenjia Cai, Can Wang, Peng Gong

Journal: Lancet Planet Health

PubMed ID: 34758346

Doi: 10.1016/S2542-5196(21)00252-7

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Authors: Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Aylwin Ng, Timothy Lehmberg, Archana Jha, Sravya Kommineni, Katherine Fletcher, Jorge Garcia-Fortanet, Yaya Fan, Qing Tang, Menghao Wei, Asmita Agrawal, Sagar R Budhe, Sreekanth R Rouduri, Dan Baird, Jeff Saunders, Janna Kiselar, Mark R Chance, Andrea Ballabio, Brent A Appleton, John H Brumell, Oliver Florey, Leon O Murphy

Journal: Sci Adv

PubMed ID: 34597140

Doi: 10.1126/sciadv.abj2485

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Identification of a MarR subfamily that regulates arsenic resistance genes

Authors: Yanshuang Yu, Jichen Chen, Yuanping Li, Jinxuan Liang, Zhenchen Xie, Renwei Feng, Hend A Alwathnani, Barry P Rosen, Anne Grove, Jian Chen, Christopher Rensing

Journal: Appl Environ Microbiol

PubMed ID: 34613763

Doi: 10.1128/AEM.01588-21

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Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta

Authors: Zhan-Ku Shi, Xiao-Wei Gong, Jiang-Yuan Zhao, Ming-Gang Li, Xiu-Lin Han, Meng-Liang Wen

Journal: J Oleo Sci

PubMed ID: 34645748

Doi: 10.5650/jos.ess21172

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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS-CoV and MERS-CoV MDs in the free and the ADPr-bound state

Authors: Aikaterini C Tsika, Nikolaos K Fourkiotis, Periklis Charalampous, Angelo Gallo, Georgios A Spyroulias

Journal: Biomol NMR Assign

PubMed ID: 34686999

Doi: 10.1007/s12104-021-10052-5

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I-SceI and customized meganucleases-mediated genome editing in tomato and oilseed rape

Authors: Benoit Danilo, Émilie Montes, Héloïse Archambeau, Maryse Lodé, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre, Marianne Mazier

Journal: Transgenic Res

PubMed ID: 34632562

Doi: 10.1007/s11248-021-00287-2

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Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits

Authors: Sumin Kang, Nam Hyuk Kim, Yeon Gyu Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 34739856

Doi: 10.1016/j.bbrc.2021.10.071

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

Authors: Melanie de Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A Versteeg, David Haselbach, Johannes Zuber

Journal: Nature

PubMed ID: 34711951

Doi: 10.1038/s41586-021-04035-8

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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice

Authors: Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z M Homer, Rosana Leiva, Santiago Vázquez, Damian J Mole, Christian Griñán-Ferré, Mercè Pallàs

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681264

Doi: 10.3390/ph14101040

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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line

Authors: Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço

Journal: Mutat Res

PubMed ID: 34710701

Doi: 10.1016/j.mrfmmm.2021.111763

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A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain

Authors: Kofi Abokitse, Stephan Grosse, Hannes Leisch, Christopher R Corbeil, Florence Perrin-Sarazin, Peter C K Lau

Journal: Appl Environ Microbiol

PubMed ID: 34705546

Doi: 10.1128/AEM.01522-21

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Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy

Authors: Anish Jadav, Kevin Truong

Journal: Integr Biol (Camb)

PubMed ID: 34632498

Doi: 10.1093/intbio/zyab015

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Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Authors: Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson

Journal: Biochemistry

PubMed ID: 34609847

Doi: 10.1021/acs.biochem.1c00600

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The pentatricopeptide repeat protein EMB1270 interacts with CFM2 to splice specific group II introns in Arabidopsis chloroplasts

Authors: Li Zhang, Jingli Chen, Liqun Zhang, Ying Wei, Yajuan Li, Xinyun Xu, Hui Wu, Zhong-Nan Yang, Jirong Huang, Fenhong Hu, Weihua Huang, Yong-Lan Cui

Journal: J Integr Plant Biol

PubMed ID: 34427970

Doi: 10.1111/jipb.13165

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Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries

Authors: Sreeparna Biswas, Priyanka Garg, Somnath Dutta, Kaza Suguna

Journal: Sci Rep

PubMed ID: 34697325

Doi: 10.1038/s41598-021-00172-2

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An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel

Authors: Valeria Guzman-Luna, Andrew M Fuchs, Anna J Allen, Alexios Staikos, Silvia Cavagnero

Journal: Commun Biol

PubMed ID: 34716402

Doi: 10.1038/s42003-021-02752-4

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N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

Authors: Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein

Journal: J Biol Chem

PubMed ID: 34732320

Doi: 10.1016/j.jbc.2021.101363

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Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection

Authors: Patrícia Mertinková, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, Mangesh Bhide

Journal: Sci Rep

PubMed ID: 34635758

Doi: 10.1038/s41598-021-99696-w

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Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen Vibrio alginolyticus

Authors: Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao

Journal: Microbiol Res

PubMed ID: 34700184

Doi: 10.1016/j.micres.2021.126900

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Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease

Authors: Giorgio Fedele, Gianluca Russo, Ilaria Schiavoni, Pasqualina Leone, Eleonora Olivetta, Valentina Perri, Maria Antonella Zingaropoli, Maria Rosa Ciardi, Patrizia Pasculli, Claudio Maria Mastroianni, Paola Stefanelli

Journal: Diagn Microbiol Infect Dis

PubMed ID: 34742119

Doi: 10.1016/j.diagmicrobio.2021.115586

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and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Authors: Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 34532729

Doi: 10.1039/d1fo02172a

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Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy

Authors: S Strazdaite, S J Roeters, A Sakalauskas, T Sneideris, J Kirschner, K B Pedersen, B Schiøtt, F Jensen, T Weidner, V Smirnovas, G Niaura

Journal: J Phys Chem B

PubMed ID: 34597059

Doi: 10.1021/acs.jpcb.1c04882

Guillain-Barré syndrome after coronavirus disease 2019 vaccine: A temporal association

Authors: Gustavo Figueiredo da Silva, Caroline Figueiredo da Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Fabiana Romancini, Rafael Marques Mendes, Amanda Locks, Maria Francisca Moro Longo, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Vera Lucia Braatz

Journal: Clin Exp Neuroimmunol

PubMed ID: 34900000

Doi: 10.1111/cen3.12678

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Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins

Authors: Ashish A Kawale, Björn M Burmann

Journal: STAR Protoc

PubMed ID: 34761231

Doi: 10.1016/j.xpro.2021.100919

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