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Reprogramming the metabolism of PCC 6803 by regulating the plastoquinone biosynthesis

Authors: Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu

Journal: Synth Syst Biotechnol

PubMed ID: 34754966

Doi: 10.1016/j.synbio.2021.10.004

Products & Services: Codon Optimization

A BK channel-targeted peptide induces age-dependent improvement in behavioral and neural sound representation

Authors: Elliott J Brecht, Luisa L Scott, Bo Ding, Xiaoxia Zhu, Joseph P Walton

Journal: Neurobiol Aging

PubMed ID: 34861480

Doi: 10.1016/j.neurobiolaging.2021.10.014

Products & Services: Proteins, Expression, Isolation and Analysis

Overexpression of the Ginkgo biloba WD40 gene GbLWD1-like improves salt tolerance in transgenic Populus

Authors: Yue Xin, Yaqiong Wu, Xin Han, Li-An Xu

Journal: Plant Sci

PubMed ID: 34763876

Doi: 10.1016/j.plantsci.2021.111092

Products & Services: Bacterial Expression

WSB1 regulates c-Myc expression through -catenin signaling and forms a feedforward circuit

Authors: Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao

Journal: Acta Pharm Sin B

PubMed ID: 35530152

Doi: 10.1016/j.apsb.2021.10.021

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Prior infection with SARS-CoV-2 boosts and broadens Ad26COV2S immunogenicity in a variant-dependent manner

Authors: Roanne Keeton, Simone I Richardson, Thandeka Moyo-Gwete, Tandile Hermanus, Marius B Tincho, Ntombi Benede, Nelia P Manamela, Richard Baguma, Zanele Makhado, Amkele Ngomti, Thopisang Motlou, Mathilda Mennen, Lionel Chinhoyi, Sango Skelem, Hazel Maboreke, Deelan Doolabh, Arash Iranzadeh, Ashley D Otter, Tim Brooks, Mahdad Noursadeghi, James C Moon, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Jonathan Blackburn, Nei-Yuan Hsiao, Carolyn Williamson, Catherine Riou, Ameena Goga, Nigel Garrett, Linda-Gail Bekker, Glenda Gray, Ntobeko A B Ntusi, Penny L Moore, Wendy A Burgers

Journal: Cell Host Microbe

PubMed ID: 34688376

Doi: 10.1016/j.chom.2021.10.003

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An inducible -Cre mouse model to monitor and manipulate -highly-expressing senescent cells

Authors: Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia, George A Kuchel, James L Kirkland, Ming Xu

Journal: Nat Aging

PubMed ID: 35024619

Doi: 10.1038/s43587-021-00107-6

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Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus

Authors: Oscar A Ortega-Rivera, Sourabh Shukla, Matthew D Shin, Angela Chen, Veronique Beiss, Miguel A Moreno-Gonzalez, Yi Zheng, Alex E Clark, Aaron F Carlin, Jonathan K Pokorski, Nicole F Steinmetz

Journal: ACS Infect Dis

PubMed ID: 34672530

Doi: 10.1021/acsinfecdis.1c00410

Products & Services: Peptide Synthesis

Polymersomes as Stable Nanocarriers for a Highly Immunogenic and Durable SARS-CoV-2 Spike Protein Subunit Vaccine

Authors: Jian Hang Lam, Amit K Khan, Thomas A Cornell, Teck Wan Chia, Regine J Dress, Wen Wang William Yeow, Nur Khairiah Mohd-Ismail, Shrinivas Venkataraman, Kim Tien Ng, Yee-Joo Tan, Danielle E Anderson, Florent Ginhoux, Madhavan Nallani

Journal: ACS Nano

PubMed ID: 34618423

Doi: 10.1021/acsnano.1c01243

Products & Services: Recombinant Antibody Expression

Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response

Authors: Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir

Journal: PLoS Pathog

PubMed ID: 34653226

Doi: 10.1371/journal.ppat.1010007

Products & Services: PCR and Cloning

Enzymatic extraction improves intracellular protein recovery from the industrial carrageenan seaweed revealed by quantitative, subcellular protein profiling: A high potential source of functional food ingredients

Authors: Simon Gregersen, Anne-Sofie Havgaard Kongsted, Rikke Brønnum Nielsen, Søren Storck Hansen, Frederik Andersen Lau, Jacob Bisgaard Rasmussen, Susan Løvstad Holdt, Charlotte Jacobsen

Journal: Food Chem X

PubMed ID: 34746746

Doi: 10.1016/j.fochx.2021.100137

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene Induced by Sound Stimulation Enhances Anthocyanin Accumulation in Grape Berry Skin through Direct Upregulation of UDP-Glucose: Flavonoid 3--Glucosyltransferase

Authors: Mone Yamazaki, Akari Ishida, Yutaka Suzuki, Yoshinao Aoki, Shunji Suzuki, Shinichi Enoki

Journal: Cells

PubMed ID: 34685779

Doi: 10.3390/cells10102799

Products & Services: PCR and Cloning

Reconstitution of Caveolin-1 into Artificial Lipid Membrane: Characterization by Transmission Electron Microscopy and Solid-State Nuclear Magnetic Resonance

Authors: Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang

Journal: Molecules

PubMed ID: 34684779

Doi: 10.3390/molecules26206201

Products & Services: Bacterial Expression

Using Continuous Directed Evolution to Improve Enzymes for Plant Applications

Authors: Jorge D García-García, Kristen Van Gelder, Jaya Joshi, Ulschan Bathe, Bryan J Leong, Steven D Bruner, Chang C Liu, Andrew D Hanson

Journal: Plant Physiol

PubMed ID: 34718794

Doi: 10.1093/plphys/kiab500

Products & Services: Recombinant Antibody Expression

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom

Journal: biorxiv

PubMed ID: 34671768

Doi: 10.1101/2021.10.12.464114

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant expression of insoluble enzymes in Escherichia coli: a systematic review of experimental design and its manufacturing implications

Authors: Suraj Mital, Graham Christie, Duygu Dikicioglu

Journal: Microb Cell Fact

PubMed ID: 34717620

Doi: 10.1186/s12934-021-01698-w

Products & Services: PCR and Cloning

Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators

Authors: Luisa Vernizzi, Christian F Lehner

Journal: PLoS Genet

PubMed ID: 34669718

Doi: 10.1371/journal.pgen.1009870

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Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Authors: Hillary H Le, Suleyman S Cinaroglu, Elise C Manalo, Aysegul Ors, Michelle M Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A Origel Marmolejo, Arnaud Quentel, Justin S Plaut, Taryn E Kawashima, E Sila Ozdemir, Sanjay V Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C Saldivar, Emel Timucin, Jared M Fischer

Journal: EBioMedicine

PubMed ID: 34689087

Doi: 10.1016/j.ebiom.2021.103646

Products & Services: Proteins, Expression, Isolation and Analysis

Stabilized coronavirus spike stem elicits a broadly protective antibody

Authors: Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Jory A Goldsmith, Chia-Wei Chou, Olubukola M Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J Fritch, Kenneth H Dinnon, Alexandra Schäfer, Mark R Denison, James D Chappell, Ralph S Baric, Barney S Graham, Kizzmekia S Corbett, Jason S McLellan

Journal: Cell Rep

PubMed ID: 34710354

Doi: 10.1016/j.celrep.2021.109929

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Robust Neutralizing Antibody Responses 6 Months Post Vaccination with BNT162b2: A Prospective Study in 308 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sentiljana Gumeni, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Life (Basel)

PubMed ID: 34685448

Doi: 10.3390/life11101077

Characterization of oleosin genes from forage sorghum in Arabidopsis and yeast reveals their role in storage lipid stability

Authors: Rabishankar Ojha, Simranjit Kaur, Kshitija Sinha, Kirti Chawla, Sumandeep Kaur, Harish Jadhav, Manmehar Kaur, Rupam Kumar Bhunia

Journal: Planta

PubMed ID: 34655341

Doi: 10.1007/s00425-021-03744-8

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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins

Authors: Kristina V Boyko, Erin A Rosenkranz, Derrick M Smith, Heather L Miears, Melissa Oueld Es Cheikh, Micah Z Lund, Jeffery C Young, Patrick N Reardon, Mark Okon, Serge L Smirnov, John M Antos

Journal: PLoS ONE

PubMed ID: 34710113

Doi: 10.1371/journal.pone.0258531

Products & Services: Plasmid DNA Preparation

Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang, Sheng Zhang

Journal: Cancer Cell Int

PubMed ID: 34663350

Doi: 10.1186/s12935-021-02257-4

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Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies

Authors: Andrew T Chen, Hannah D Stacey, Art Marzok, Pardeep Singh, Jann Ang, Matthew S Miller, Mark Loeb

Journal: Vaccine

PubMed ID: 34756613

Doi: 10.1016/j.vaccine.2021.10.021

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Authors: Jazmine P Hallinan, Lindsey A Doyle, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

Journal: Commun Biol

PubMed ID: 34716407

Doi: 10.1038/s42003-021-02766-y

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Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway

Authors: Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu

Journal: Evid Based Complement Alternat Med

PubMed ID: 34646326

Doi: 10.1155/2021/5561999

Products & Services: Proteins, Expression, Isolation and Analysis

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

Journal: Biol Direct

PubMed ID: 34674770

Doi: 10.1186/s13062-021-00305-7

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Zinc Influx Restricts Enterovirus D68 Replication

Authors: Shunan Liu, Xia Cao, Haoran Guo, Wei Wei

Journal: Front Microbiol

PubMed ID: 34721351

Doi: 10.3389/fmicb.2021.748546

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High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1

Authors: Xiaoli Tang, Xiaogang Ye, Xiaoxiao Wang, Shuo Zhao, Meiyu Wu, Jinghua Ruan, Boxiong Zhong

Journal: Sci Rep

PubMed ID: 34697320

Doi: 10.1038/s41598-021-00029-8

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Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors

Authors: Michalis Liontos, Evangelos Terpos, Christos Markellos, Flora Zagouri, Alexandros Briasoulis, Ioanna Katsiana, Efthymia Skafida, Oraianthi Fiste, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34696256

Doi: 10.3390/vaccines9101148

Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis

Authors: Annalisa Pianta, Geena Chiumento, Kristina Ramsden, Qi Wang, Klemen Strle, Sheila Arvikar, Catherine E Costello, Allen C Steere

Journal: Arthritis Rheumatol

PubMed ID: 34042327

Doi: 10.1002/art.41807

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology

Authors: Xiaoyu Du, Yuqin Wang, Shanyu Zhang, Pingping Fan, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Anal Chem

PubMed ID: 34641671

Doi: 10.1021/acs.analchem.1c02775

Products & Services: Plasmid DNA Preparation

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Authors: Shalom D Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin

Journal: Pharmaceutics

PubMed ID: 34683962

Doi: 10.3390/pharmaceutics13101669

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Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Authors: Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki

Journal: J Exp Med

PubMed ID: 34647971

Doi: 10.1084/jem.20211327

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Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Authors: Harriet P Lo, Ye-Wheen Lim, Zherui Xiong, Nick Martel, Charles Ferguson, Nicholas Ariotti, Jean Giacomotto, James Rae, Matthias Floetenmeyer, Shayli Varasteh Moradi, Ya Gao, Vikas A Tillu, Di Xia, Huang Wang, Samira Rahnama, Susan J Nixon, Michele Bastiani, Ryan D Day, Kelly A Smith, Nathan J Palpant, Wayne A Johnston, Kirill Alexandrov, Brett M Collins, Thomas E Hall, Robert G Parton

Journal: J Cell Biol

PubMed ID: 34633413

Doi: 10.1083/jcb.201905065

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Profiling sirtuin activity using Copper-free click chemistry

Authors: Alyson M Curry, Ian Cohen, Song Zheng, Jessica Wohlfahrt, Dawanna S White, Dickson Donu, Yana Cen

Journal: Bioorg Chem

PubMed ID: 34655842

Doi: 10.1016/j.bioorg.2021.105413

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T cells promote metastasis by regulating extracellular matrix remodeling following chemotherapy

Authors: Jozafina Haj-Shomaly, Avital Vorontsova, Tamar Barenholz-Cohen, Oshrat Levi-Galibov, Mahesh Devarasetty, Michael Timaner, Ziv Raviv, Tim J Cooper, Shay Soker, Peleg Hasson, Daphne Weihs, Ruth Scherz-Shouval, Yuval Shaked

Journal: Cancer Res

PubMed ID: 34666995

Doi: 10.1158/0008-5472.CAN-21-1012

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Label-Free Colorimetric Method for Detection of by Trimming the G-Quadruplex DNAzyme with CRISPR/Cas12a

Authors: Xueyun Chen, Liu Wang, Fang He, Ganghui Chen, Linlin Bai, Kaiyu He, Fang Zhang, Xiahong Xu

Journal: Anal Chem

PubMed ID: 34645259

Doi: 10.1021/acs.analchem.1c03468

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Exosome-mediated delivery of inflammation-responsive mRNA for controlled atherosclerosis treatment

Authors: Te Bu, Zhelong Li, Ying Hou, Wenqi Sun, Rongxin Zhang, Lianbi Zhao, Mengying Wei, Guodong Yang, Lijun Yuan

Journal: Theranostics

PubMed ID: 34815799

Doi: 10.7150/thno.64229

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21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules

Authors: Alexander Hellesen, Sigrid Aslaksen, Lars Breivik, Ellen Christine Røyrvik, Øyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne Bøe Wolff, Eystein Sverre Husebye, Eirik Bratland

Journal: Front Immunol

PubMed ID: 34721410

Doi: 10.3389/fimmu.2021.742848

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A comparative study of mesenchymal stem cells cultured as cell-only aggregates and in encapsulated hydrogels

Authors: Fiona R Passanha, David B Gomes, Justyna Piotrowska, Lorenzo Moroni, Matthew B Baker, Vanessa L S LaPointe

Journal: J Tissue Eng Regen Med

PubMed ID: 34655456

Doi: 10.1002/term.3257

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Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR

Authors: Christopher Szeto, Andrea T Nguyen, Christian A Lobos, Demetra S M Chatzileontiadou, Dhilshan Jayasinghe, Emma J Grant, Alan Riboldi-Tunnicliffe, Corey Smith, Stephanie Gras

Journal: Cells

PubMed ID: 34685626

Doi: 10.3390/cells10102646

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Evaluation of the correlation between the access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test

Authors: Yutaro Kitagawa, Kazuo Imai, Masaru Matsuoka, Ai Fukada, Katsumi Kubota, Momoko Sato, Tomohito Takada, Sakiko Noguchi, Norihito Tarumoto, Shigefumi Maesaki, Shinichi Takeuchi, Takuya Maeda

Journal: J Med Virol

PubMed ID: 34524695

Doi: 10.1002/jmv.27338

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AuNPs- Aβ-Ni-HRP sandwich assay: A new sensitive colorimetric method for the detection of Aβ

Authors: Zeeshan A Khan, Seungkyung Park

Journal: Talanta

PubMed ID: 34736673

Doi: 10.1016/j.talanta.2021.122946

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TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Interaction With SYK in Experimental Subarachnoid Hemorrhage

Authors: Xinyan Wu, Hanhai Zeng, Chaoran Xu, Huaijun Chen, Linfeng Fan, Hang Zhou, Qian Yu, Xiongjie Fu, Yucong Peng, Feng Yan, Xiaobo Yu, Gao Chen

Journal: Front Immunol

PubMed ID: 34721438

Doi: 10.3389/fimmu.2021.766178

Products & Services: Recombinant Antibody Expression

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Authors: Xianglei Liu, Doncho Zhelev, Cynthia Adams, Chuan Chen, John W Mellors, Dimiter S Dimitrov

Journal: Transl Oncol

PubMed ID: 34601396

Doi: 10.1016/j.tranon.2021.101232

Products & Services: Proteins, Expression, Isolation and Analysis

Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Authors: Irani Alves Ferreira-Bravo, Jeffrey J DeStefano

Journal: Viruses

PubMed ID: 34696413

Doi: 10.3390/v13101983

Products & Services: Proteins, Expression, Isolation and Analysis

Low-Field NMR Analysis of Chicken Patties Prepared with Woody Breast Meat and Implications to Meat Quality

Authors: Xiao Sun, Jinjie You, Yan Dong, Ligen Xu, Clay J Maynard, Casey M Owens

Journal: Foods

PubMed ID: 34681548

Doi: 10.3390/foods10102499

Products & Services: Proteins, Expression, Isolation and Analysis

Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations

Authors: Rafat Zrieq, Iqrar Ahmad, Mejdi Snoussi, Emira Noumi, Marcello Iriti, Fahad D Algahtani, Harun Patel, Mohd Saeed, Munazzah Tasleem, Shadi Sulaiman, Kaïss Aouadi, Adel Kadri

Journal: Int J Mol Sci

PubMed ID: 34639036

Doi: 10.3390/ijms221910693

Products & Services: Proteins, Expression, Isolation and Analysis

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

Authors: Holly Fowle, Ziran Zhao, Qifang Xu, Jason S Wasserman, Xinru Wang, Mary Adeyemi, Felicity Feiser, Alison N Kurimchak, Diba Atar, Brennan C McEwan, Arminja N Kettenbach, Rebecca Page, Wolfgang Peti, Roland L Dunbrack, Xavier Graña

Journal: Elife

PubMed ID: 34661528

Doi: 10.7554/eLife.63181

Products & Services: Proteins, Expression, Isolation and Analysis

miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis

Authors: Diego López-Márquez, Ángel Del-Espino, Nieves López-Pagán, Edgar A Rodríguez-Negrete, Ignacio Rubio-Somoza, Javier Ruiz-Albert, Eduardo R Bejarano, Carmen R Beuzón

Journal: J Exp Bot

PubMed ID: 34329403

Doi: 10.1093/jxb/erab354

Products & Services: Proteins, Expression, Isolation and Analysis

Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells

Authors: Kosuke Yokobori, Yuki Kawasaki, Yoshitaka Sekine, Sumihito Nobusawa, Toshiyuki Sakaki, Masahiko Negishi, Satoru Kakizaki

Journal: Biochem Pharmacol

PubMed ID: 34715066

Doi: 10.1016/j.bcp.2021.114794

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Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Authors: Brion W Murray, Evan Rogers, Dayong Zhai, Wei Deng, Xi Chen, Paul A Sprengeler, Xin Zhang, Armin Graber, Siegfried H Reich, Shanna Stopatschinskaja, Benjamin Solomon, Benjamin Besse, Alexander Drilon

Journal: Mol Cancer Ther

PubMed ID: 34625502

Doi: 10.1158/1535-7163.MCT-21-0632

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MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling

Authors: Jianping Cao, Meng Jiang, Huafeng Ren, Kai Xu

Journal: Mol Med Rep

PubMed ID: 34676879

Doi: 10.3892/mmr.2021.12505

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KDM5B protein expressed in viable and fertile ΔARID mice exhibit no demethylase activity

Authors: Shirin Jamshidi, Steven Catchpole, Jie Chen, Chi Wai Eric So, Joy Burchell, Khondaker Miraz Rahman, Joyce Taylor-Papadimitriou

Journal: Int J Oncol

PubMed ID: 34713299

Doi: 10.3892/ijo.2021.5276

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Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability

Authors: Simona Graziano, Nuria Coll-Bonfill, Barbara Teodoro-Castro, Sahiti Kuppa, Jessica Jackson, Elena Shashkova, Urvashi Mahajan, Alessandro Vindigni, Edwin Antony, Susana Gonzalo

Journal: J Biol Chem

PubMed ID: 34648766

Doi: 10.1016/j.jbc.2021.101301

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Influence of Primary Structure on Fragmentation of Native-Like Proteins by Ultraviolet Photodissociation

Authors: Luis A Macias, Sarah N Sipe, Inês C Santos, Aarti Bashyal, M Rachel Mehaffey, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 34714071

Doi: 10.1021/jasms.1c00269

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Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy

Authors: Feng Xie, Peng Su, Ting Pan, Xiaoxue Zhou, Heyu Li, Huizhe Huang, Aijun Wang, Fangwei Wang, Jun Huang, Haiyan Yan, Linghui Zeng, Long Zhang, Fangfang Zhou

Journal: Adv Mater

PubMed ID: 34665481

Doi: 10.1002/adma.202103471

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A BioBricks toolbox for metabolic engineering of the tetracenomycin pathway

Authors: Jennifer T Nguyen, Kennedy K Riebschleger, Katelyn V Brown, Nina M Gorgijevska, S Eric Nybo

Journal: Biotechnol J.

PubMed ID: 34719127

Doi: doi.org/10.1002/biot.202100371

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Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns

Authors: Stefan Hümmer, Sonia Borao, Angel Guerra-Moreno, Luca Cozzuto, Elena Hidalgo, José Ayté

Journal: Cell Rep

PubMed ID: 34706246

Doi: 10.1016/j.celrep.2021.109893

Products & Services: PCR Cloning and Subcloning

The expression, localisation and interactome of pigeon CRY2

Authors: Spencer D Balay, Tobias Hochstoeger, Alexandra Vilceanu, E Pascal Malkemper, William Snider, Gerhard Dürnberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C Nordmann, Lyubov Ushakova, Simon Nimpf, David A Keays

Journal: Sci Rep

PubMed ID: 34645873

Doi: 10.1038/s41598-021-99207-x

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Newcastle Disease Virus Vectored Chicken Infectious Anaemia Vaccine Induces Robust Immune Response in Chickens

Authors: Madhan Mohan Chellappa, Sohini Dey, Dinesh Chandra Pathak, Asmita Singh, Narayan Ramamurthy, Saravanan Ramakrishnan, Asok Kumar Mariappan, Kuldeep Dhama, Vikram N Vakharia

Journal: Viruses

PubMed ID: 34696415

Doi: 10.3390/v13101985

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Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Authors: Andreas Greinacher, Kathleen Selleng, Julia Mayerle, Raghavendra Palankar, Jan Wesche, Sven Reiche, Andrea Aebischer, Theodore E Warkentin, Maximilian Muenchhoff, Johannes C Hellmuth, Oliver T Keppler, Daniel Duerschmied, Achim Lother, Siegbert Rieg, Meinrad Paul Gawaz, Karin Anne Lydia Mueller, Christian S Scheer, Matthias Napp, Klaus Hahnenkamp, Guglielmo Lucchese, Antje Vogelgesang, Agnes Flöel, Piero Lovreglio, Angela Stufano, Rolf Marschalek, Thomas Thiele

Journal: Blood

PubMed ID: 34280256

Doi: 10.1182/blood.2021012938

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The Sigma-1 receptor is an ER-localized type II membrane protein

Authors: Neeraj Sharma, Chaitanya Patel, Marina Shenkman, Amit Kessel, Nir Ben-Tal, Gerardo Z Lederkremer

Journal: J Biol Chem

PubMed ID: 34648767

Doi: 10.1016/j.jbc.2021.101299

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Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure

Authors: Wai Shun Mak, Tsz Ming Tsang, Tsz Yin Chan, Georgi L Lukov

Journal: Proteomes

PubMed ID: 34698247

Doi: 10.3390/proteomes9040040

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A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells

Authors: Thomas Welte, Junhua Mai, Zhe Zhang, Shaohui Tian, Guodong Zhang, Yitian Xu, Licheng Zhang, Shu-Shia Chen, Tian Wang, Haifa Shen

Journal: iScience

PubMed ID: 34825135

Doi: 10.1016/j.isci.2021.103349

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Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom

Authors: Sherin Kaul, L Sai Keerthana, Pankaj Kumar, Komal Birader, Yathirajarao Tammineni, Deepali Rawat, Pankaj Suman

Journal: PLoS Negl Trop Dis

PubMed ID: 34634067

Doi: 10.1371/journal.pntd.0009841

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The periplasmic expression and purification of AA15 lytic polysaccharide monooxygenases from insect species in Escherichia coli

Authors: João Paulo L Franco Cairo, Dnane V Almeida, André Damasio, Wanius Garcia, Fabio M Squina

Journal: Protein Expr Purif

PubMed ID: 34655732

Doi: 10.1016/j.pep.2021.105994

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Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in and

Authors: Haley S Ball, Misgina B Girma, Mosufa Zainab, Iswarduth Soojhawon, Robin D Couch, Schroeder M Noble

Journal: ACS Infect Dis

PubMed ID: 34672535

Doi: 10.1021/acsinfecdis.1c00132

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Bacterial Quorum-Quenching Lactonase Hydrolyzes Fungal Mycotoxin and Reduces Pathogenicity of -Suggesting a Mechanism of Bacterial Antagonism

Authors: Shlomit Dor, Dov Prusky, Livnat Afriat-Jurnou

Journal: J Fungi (Basel)

PubMed ID: 34682247

Doi: 10.3390/jof7100826

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Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins

Authors: Tomomi Shionoya, Manish Singh, Misao Mizuno, Hideki Kandori, Yasuhisa Mizutani

Journal: Biochemistry

PubMed ID: 34601881

Doi: 10.1021/acs.biochem.1c00529

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A Thermostable Cas12b from Leverages One-pot Detection of SARS-CoV-2 Variants of Concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: medrxiv

PubMed ID: 34704101

Doi: 10.1101/2021.10.15.21265066

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Homocysteine Inhibits Pro-Insulin Receptor Cleavage and Causes Insulin Resistance Via Protein Cysteine-Homocysteinylation

Authors: Xuan Zhang, Yuan-Yuan Qu, Lian Liu, Ya-Nan Qiao, Hao-Ran Geng, Yan Lin, Wei Xu, Jing Cao, Jian-Yuan Zhao

Journal: Cell Rep

PubMed ID: 34644569

Doi: 10.2139/ssrn.3830772

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Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang

Journal: Viruses

PubMed ID: 34834981

Doi: 10.3390/v13112175

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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

Authors: Sanket S Ponia, Shelly J Robertson, Kristin L McNally, Gayatri Subramanian, Gail L Sturdevant, Matthew Lewis, Forrest Jessop, Catherine Kendall, Dylan Gallegos, Arielle Hay, Cindi Schwartz, Rebecca Rosenke, Greg Saturday, Catherine M Bosio, Craig Martens, Sonja M Best

Journal: Cell Rep

PubMed ID: 34706234

Doi: 10.1016/j.celrep.2021.109888

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Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost

Authors: Tamara Davidovic, Judith Schimpf, Armin Abbassi-Nik, Richard Stockinger, Hannelore Sprenger-Mähr, Karl Lhotta, Emanuel Zitt

Journal: Kidney Int

PubMed ID: 34656642

Doi: 10.1016/j.kint.2021.10.006

Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Authors: Naiyan Lu, Xinhe Wang, Wentao Shi, Lu Bian, Xuan Zhang, Guofeng Yang, Xue Tang, Jun Wang, Yin Zou, Yuyan Weng

Journal: Nanoscale Res Lett

PubMed ID: 34637014

Doi: 10.1186/s11671-021-03610-2

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In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain

Authors: Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Linnea Molander, Johannes Fuchs, Ruth H Palmer

Journal: J Mol Biol

PubMed ID: 34624297

Doi: 10.1016/j.jmb.2021.167282

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Quantifying oxidation of cellulose-associated glucuronoxylan by two lytic polysaccharide monooxygenases from

Authors: Olav A Hegnar, Heidi Østby, Dejan M Petrović, Lisbeth Olsson, Anikó Várnai, Vincent G H Eijsink

Journal: Appl Environ Microbiol

PubMed ID: 34613755

Doi: 10.1128/AEM.01652-21

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CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Authors: Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu

Journal: Theranostics

PubMed ID: 34815788

Doi: 10.7150/thno.62187

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Combining an optimized mRNA template with a double purification process allows strong expression of transcribed mRNA

Authors: Sergio Linares-Fernández, Julien Moreno, Elise Lambert, Perrine Mercier-Gouy, Laetitia Vachez, Bernard Verrier, Jean-Yves Exposito

Journal: Mol Ther Nucleic Acids

PubMed ID: 34692232

Doi: 10.1016/j.omtn.2021.10.007

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Epitopes prediction for microcystin-LR by molecular docking

Authors: Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34717216

Doi: 10.1016/j.ecoenv.2021.112925

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Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Authors: Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann

Journal: Elife

PubMed ID: 34713805

Doi: 10.7554/eLife.69832

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Aptamer-modified biosensors to visualize neurotransmitter flux

Authors: Charlotte Moraldo, Emilie Vuille-Dit-Bille, Bajramshahe Shkodra, Tom Kloter, Nako Nakatsuka

Journal: J Neurosci Methods

PubMed ID: 34653500

Doi: 10.1016/j.jneumeth.2021.109386

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Anastrozole regulates fatty acid synthase in breast cancer

Authors: Junmei Cairns, James N Ingle, Krishna R Kalari, Matthew P Goetz, Richard M Weinshilboum, Huanyao Gao, Hu Li, Mehrab Ghanat Bari, Liewei Wang

Journal: Mol Cancer Ther

PubMed ID: 34667110

Doi: 10.1158/1535-7163.MCT-21-0509

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Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Authors: Young-Jun Park, Anna De Marco, Tyler N Starr, Zhuoming Liu, Dora Pinto, Alexandra C Walls, Fabrizia Zatta, Samantha K Zepeda, John Bowen, Kaitlin S Sprouse, Anshu Joshi, Martina Giurdanella, Barbara Guarino, Julia Noack, Rana Abdelnabi, Shi-Yan Caroline Foo, Florian A Lempp, Fabio Benigni, Gyorgy Snell, Johan Neyts, Sean Pj Whelan, Herbert W Virgin, Jesse D Bloom, Davide Corti, Matteo Samuele Pizzuto, David Veesler

Journal: biorxiv

PubMed ID: 34671770

Doi: 10.1101/2021.10.13.464254

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Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

Authors: Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu

Journal: Front Cell Dev Biol

PubMed ID: 34778244

Doi: 10.3389/fcell.2021.666025

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Design of a synthesis-friendly hypoxia-responsive promoter for cell-based therapeutics

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Eng Life Sci

PubMed ID: 34899121

Doi: 10.1002/elsc.202100045

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Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

Authors: Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Journal: iScience

PubMed ID: 34825148

Doi: 10.1016/j.isci.2021.103396

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MYB70 modulates seed germination and root system development in

Authors: Jinpeng Wan, Ruling Wang, Ping Zhang, Liangliang Sun, Qiong Ju, Haodong Huang, Shiyou Lü, Lam-Son Tran, Jin Xu

Journal: iScience

PubMed ID: 34746697

Doi: 10.1016/j.isci.2021.103228

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Structure-Function Analysis of Resistance to Bamlanivimab by SARS-CoV-2 Variants Kappa, Delta, and Lambda

Authors: Shufeng Liu, Tien Huynh, Charles B Stauft, Tony T Wang, Binquan Luan

Journal: J Chem Inf Model

PubMed ID: 34648284

Doi: 10.1021/acs.jcim.1c01058

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Effect of Cotton Leafroll Dwarf Virus on Physiological Processes and Yield of Individual Cotton Plants

Authors: Ved Parkash, Divya Bhanu Sharma, John Snider, Sudeep Bag, Phillip Roberts, Afsha Tabassum, Dalton West, Sameer Khanal, Nelson Suassuna, Peng Chee

Journal: Front Plant Sci

PubMed ID: 34659302

Doi: 10.3389/fpls.2021.734386

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NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Authors: Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J Ulevitch, Jiahuai Han

Journal: Sci Adv

PubMed ID: 34678072

Doi: 10.1126/sciadv.abi9471

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An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Authors: Martijn A Langereis, Irina C Albulescu, Judith Stammen-Vogelzangs, Morindy Lambregts, Ken Stachura, Suzan Miller, Angela M Bosco-Lauth, Airn E Hartwig, Stephanie M Porter, Michelle Allen, Mark Mogler, Frank J M van Kuppeveld, Berend-Jan Bosch, Paul Vermeij, Ad de Groof, Richard A Bowen, Randy Davis, Zach Xu, Ian Tarpey

Journal: npj Vaccines

PubMed ID: 34671047

Doi: 10.1038/s41541-021-00390-9

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Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Authors: Marumi Ohno, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md Abdul Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida, Hirofumi Sawa, Masashi Shingai

Journal: Viruses

PubMed ID: 34834944

Doi: 10.3390/v13112137

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The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

Authors: Kevin J Forsberg, Danica T Schmidtke, Rachel Werther, Ruben V Uribe, Deanna Hausman, Morten O A Sommer, Barry L Stoddard, Brett K Kaiser, Harmit S Malik

Journal: PLoS Biol

PubMed ID: 34644300

Doi: 10.1371/journal.pbio.3001428

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Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation

Authors: Krishna K Sarangapani, Lori B Koch, Christian R Nelson, Charles L Asbury, Sue Biggins

Journal: J Cell Biol

PubMed ID: 34647959

Doi: 10.1083/jcb.202106130

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Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia

Authors: Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palanikumar, Nair Reeshma Radhakrishnan, Mohammed Yasar M, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews

Journal: Blood Adv

PubMed ID: 34625794

Doi: 10.1182/bloodadvances.2021005300

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Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

Authors: Katelyn Mika, Mirna Marinić, Manvendra Singh, Joanne Muter, Jan Joris Brosens, Vincent J Lynch

Journal: Elife

PubMed ID: 34623259

Doi: 10.7554/eLife.69584

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