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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Authors: Su-Jeong Kim, Anjali Devgan, Brendan Miller, Sam Mool Lee, Hiroshi Kumagai, Kenneth A Wilson, Gabriella Wassef, Richard Wong, Hemal H Mehta, Pinchas Cohen, Kelvin Yen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34624450

Doi: 10.1016/j.bbagen.2021.130017

Products & Services: Mammalian Expression

Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides

Authors: Matevž Rumpret, Helen J von Richthofen, Maarten van der Linden, Geertje H A Westerlaken, Cami Talavera Ormeño, Jos A G van Strijp, Meytal Landau, Huib Ovaa, Nina M van Sorge, Linde Meyaard

Journal: FASEB J

PubMed ID: 34533845

Doi: 10.1096/fj.202100812R

Products & Services: Mammalian Expression

fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling During Seed Germination and Seedling Development

Authors: Lin Liang, Qi Wang, Zihao Song, Yaxin Wu, Qing Liang, Qingsong Wang, Jinli Yang, Ying Bi, Wen Zhou, Liu-Min Fan

Journal: Front Plant Sci

PubMed ID: 34712252

Doi: 10.3389/fpls.2021.724144

Products & Services: Mammalian Expression

A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons

Authors: Blaise M Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N Bledsoe, Bryanna N Vacca, Tullia V Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G Klein

Journal: Pharmacol Res Perspect

PubMed ID: 34476911

Doi: 10.1002/prp2.859

Products & Services: Mammalian Expression

Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication

Authors: Charlotte Flory, Kitti Wing Ki Chan, Amanda Makha Bifani, Milly Ming Ju Choy, Julien Lescar, Eng Eong Ooi, Norbert Tautz, Subhash G Vasudevan

Journal: Antiviral Res

PubMed ID: 34699863

Doi: 10.1016/j.antiviral.2021.105194

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The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni

Authors: Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie

Journal: Nucleic Acids Res

PubMed ID: 34551436

Doi: 10.1093/nar/gkab818

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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Authors: Peter J Chen, Jeffrey A Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W Nelson, Gregory A Newby, Mustafa Sahin, Mark J Osborn, Jonathan S Weissman, Britt Adamson, David R Liu

Journal: Cell

PubMed ID: 34653350

Doi: 10.1016/j.cell.2021.09.018

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Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway

Authors: Haoming Wu, Yang Wang, Qianqian Yao, Linlin Fan, Lu Meng, Nan Zheng, Huiying Li, Jiaqi Wang

Journal: Int Immunopharmacol

PubMed ID: 34634739

Doi: 10.1016/j.intimp.2021.108149

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Incorporating health co-benefits into technology pathways to achieve China's 2060 carbon neutrality goal: a modelling study

Authors: Shihui Zhang, Kangxin An, Jin Li, Yuwei Weng, Shaohui Zhang, Shuxiao Wang, Wenjia Cai, Can Wang, Peng Gong

Journal: Lancet Planet Health

PubMed ID: 34758346

Doi: 10.1016/S2542-5196(21)00252-7

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Authors: Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Aylwin Ng, Timothy Lehmberg, Archana Jha, Sravya Kommineni, Katherine Fletcher, Jorge Garcia-Fortanet, Yaya Fan, Qing Tang, Menghao Wei, Asmita Agrawal, Sagar R Budhe, Sreekanth R Rouduri, Dan Baird, Jeff Saunders, Janna Kiselar, Mark R Chance, Andrea Ballabio, Brent A Appleton, John H Brumell, Oliver Florey, Leon O Murphy

Journal: Sci Adv

PubMed ID: 34597140

Doi: 10.1126/sciadv.abj2485

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Identification of a MarR subfamily that regulates arsenic resistance genes

Authors: Yanshuang Yu, Jichen Chen, Yuanping Li, Jinxuan Liang, Zhenchen Xie, Renwei Feng, Hend A Alwathnani, Barry P Rosen, Anne Grove, Jian Chen, Christopher Rensing

Journal: Appl Environ Microbiol

PubMed ID: 34613763

Doi: 10.1128/AEM.01588-21

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Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta

Authors: Zhan-Ku Shi, Xiao-Wei Gong, Jiang-Yuan Zhao, Ming-Gang Li, Xiu-Lin Han, Meng-Liang Wen

Journal: J Oleo Sci

PubMed ID: 34645748

Doi: 10.5650/jos.ess21172

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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS-CoV and MERS-CoV MDs in the free and the ADPr-bound state

Authors: Aikaterini C Tsika, Nikolaos K Fourkiotis, Periklis Charalampous, Angelo Gallo, Georgios A Spyroulias

Journal: Biomol NMR Assign

PubMed ID: 34686999

Doi: 10.1007/s12104-021-10052-5

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I-SceI and customized meganucleases-mediated genome editing in tomato and oilseed rape

Authors: Benoit Danilo, Émilie Montes, Héloïse Archambeau, Maryse Lodé, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre, Marianne Mazier

Journal: Transgenic Res

PubMed ID: 34632562

Doi: 10.1007/s11248-021-00287-2

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Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits

Authors: Sumin Kang, Nam Hyuk Kim, Yeon Gyu Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 34739856

Doi: 10.1016/j.bbrc.2021.10.071

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

Authors: Melanie de Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A Versteeg, David Haselbach, Johannes Zuber

Journal: Nature

PubMed ID: 34711951

Doi: 10.1038/s41586-021-04035-8

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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice

Authors: Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z M Homer, Rosana Leiva, Santiago Vázquez, Damian J Mole, Christian Griñán-Ferré, Mercè Pallàs

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681264

Doi: 10.3390/ph14101040

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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line

Authors: Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço

Journal: Mutat Res

PubMed ID: 34710701

Doi: 10.1016/j.mrfmmm.2021.111763

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A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain

Authors: Kofi Abokitse, Stephan Grosse, Hannes Leisch, Christopher R Corbeil, Florence Perrin-Sarazin, Peter C K Lau

Journal: Appl Environ Microbiol

PubMed ID: 34705546

Doi: 10.1128/AEM.01522-21

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Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy

Authors: Anish Jadav, Kevin Truong

Journal: Integr Biol (Camb)

PubMed ID: 34632498

Doi: 10.1093/intbio/zyab015

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Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Authors: Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson

Journal: Biochemistry

PubMed ID: 34609847

Doi: 10.1021/acs.biochem.1c00600

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The pentatricopeptide repeat protein EMB1270 interacts with CFM2 to splice specific group II introns in Arabidopsis chloroplasts

Authors: Li Zhang, Jingli Chen, Liqun Zhang, Ying Wei, Yajuan Li, Xinyun Xu, Hui Wu, Zhong-Nan Yang, Jirong Huang, Fenhong Hu, Weihua Huang, Yong-Lan Cui

Journal: J Integr Plant Biol

PubMed ID: 34427970

Doi: 10.1111/jipb.13165

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Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries

Authors: Sreeparna Biswas, Priyanka Garg, Somnath Dutta, Kaza Suguna

Journal: Sci Rep

PubMed ID: 34697325

Doi: 10.1038/s41598-021-00172-2

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An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel

Authors: Valeria Guzman-Luna, Andrew M Fuchs, Anna J Allen, Alexios Staikos, Silvia Cavagnero

Journal: Commun Biol

PubMed ID: 34716402

Doi: 10.1038/s42003-021-02752-4

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N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

Authors: Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein

Journal: J Biol Chem

PubMed ID: 34732320

Doi: 10.1016/j.jbc.2021.101363

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Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection

Authors: Patrícia Mertinková, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, Mangesh Bhide

Journal: Sci Rep

PubMed ID: 34635758

Doi: 10.1038/s41598-021-99696-w

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Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen Vibrio alginolyticus

Authors: Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao

Journal: Microbiol Res

PubMed ID: 34700184

Doi: 10.1016/j.micres.2021.126900

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Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease

Authors: Giorgio Fedele, Gianluca Russo, Ilaria Schiavoni, Pasqualina Leone, Eleonora Olivetta, Valentina Perri, Maria Antonella Zingaropoli, Maria Rosa Ciardi, Patrizia Pasculli, Claudio Maria Mastroianni, Paola Stefanelli

Journal: Diagn Microbiol Infect Dis

PubMed ID: 34742119

Doi: 10.1016/j.diagmicrobio.2021.115586

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and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Authors: Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 34532729

Doi: 10.1039/d1fo02172a

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Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy

Authors: S Strazdaite, S J Roeters, A Sakalauskas, T Sneideris, J Kirschner, K B Pedersen, B Schiøtt, F Jensen, T Weidner, V Smirnovas, G Niaura

Journal: J Phys Chem B

PubMed ID: 34597059

Doi: 10.1021/acs.jpcb.1c04882

Guillain-Barré syndrome after coronavirus disease 2019 vaccine: A temporal association

Authors: Gustavo Figueiredo da Silva, Caroline Figueiredo da Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Fabiana Romancini, Rafael Marques Mendes, Amanda Locks, Maria Francisca Moro Longo, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Vera Lucia Braatz

Journal: Clin Exp Neuroimmunol

PubMed ID: 34900000

Doi: 10.1111/cen3.12678

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Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins

Authors: Ashish A Kawale, Björn M Burmann

Journal: STAR Protoc

PubMed ID: 34761231

Doi: 10.1016/j.xpro.2021.100919

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The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression

Authors: Yingying Gao, Jinrui Yang, Xiaobei Zhang, Aizhong Chen, Zhouhang Gu, Zhiyou Du

Journal: Front Microbiol

PubMed ID: 34745069

Doi: 10.3389/fmicb.2021.760937

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A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites

Authors: Tianze Zhang, Chenyang Li, Mengji Cao, Dan Wang, Qi Wang, Yi Xie, Shibo Gao, Shuai Fu, Xueping Zhou, Jianxiang Wu

Journal: Front Microbiol

PubMed ID: 34721366

Doi: 10.3389/fmicb.2021.757451

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Mutations Suppressing the Lack of Prepilin Peptidase Provide Insights Into the Maturation of the Major Pilin Protein in Cyanobacteria

Authors: Markéta Linhartová, Petra Skotnicová, Kaisa Hakkila, Martin Tichý, Josef Komenda, Jana Knoppová, Joan F Gilabert, Victor Guallar, Taina Tyystjärvi, Roman Sobotka

Journal: Front Microbiol

PubMed ID: 34712217

Doi: 10.3389/fmicb.2021.756912

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Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Authors: Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco

Journal: Front Pharmacol

PubMed ID: 34671260

Doi: 10.3389/fphar.2021.746628

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Effectively auto-regulated adsorption and recovery of rare earth elements via an engineered E coli

Authors: Xiaoman Xie, Xirui Tan, Yiyan Yu, Yunchong Li, Pengbo Wang, Yuanhao Liang, Yunjun Yan

Journal: J Hazard Mater

PubMed ID: 34775317

Doi: 10.1016/j.jhazmat.2021.127642

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Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

Authors: Anahita Nejatfard, Nicholas Wauer, Satarupa Bhaduri, Adam Conn, Saroj Gourkanti, Narinderbir Singh, Tiffany Kuo, Rachel Kandel, Rommie E Amaro, Sonya E Neal

Journal: Cell Rep

PubMed ID: 34686332

Doi: 10.1016/j.celrep.2021.109840

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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Authors: Ning Tsao, Joshua R Brickner, Rebecca Rodell, Adit Ganguly, Matthew Wood, Clement Oyeniran, Tanveer Ahmad, Hua Sun, Albino Bacolla, Lisheng Zhang, Valentina Lukinović, Jennifer M Soll, Brittany A Townley, Alexandre G Casanova, John A Tainer, Chuan He, Alessandro Vindigni, Nicolas Reynoird, Nima Mosammaparast

Journal: Mol Cell

PubMed ID: 34686315

Doi: 10.1016/j.molcel.2021.09.024

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Nep1‐like Proteins from Valsa mali Differentially Regulate Pathogen Virulence and Response to Abiotic Stresses

Authors: Jianying Liu, Jiajun Nie, Yali Chang, Lili Huang

Journal: Journal of Fungi

Doi: 10.3390/jof7100830

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Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Authors: Chenxi Li, Yanyang Zhou, Xuan Chen, Yanbing Zhang, Jingbo Hu, Cicheng Ren, Jingjing Ding, Daoyuan Jiang, Yanhua Li

Journal: Dev Comp Immunol

PubMed ID: 34626690

Doi: 10.1016/j.dci.2021.104290

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USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates

Authors: Thang Van Nguyen

Journal: Proc Natl Acad Sci USA

PubMed ID: 34583995

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Roles of Small Subunits of Laccase (ssPOXA3a/b) in Laccase Production by Pleurotus eryngii var. ferulae

Authors: Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding

Journal: J Agric Food Chem.

PubMed ID: 34696587

Doi: doi.org/10.1021/acs.jafc.1c04777

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Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

Authors: Isabel Pablos, Yoan Machado, Hugo C Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A Bell, Georgina S Butler, Peter M Grin, Quynh T Cao, Jenny P Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N Kizhakkedathu, Karen Mossman, Jeremy A Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M Overall

Journal: Cell Rep

PubMed ID: 34672947

Doi: 10.1016/j.celrep.2021.109892

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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors: Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong

Journal: Signal Transduct Target Ther

PubMed ID: 34645784

Doi: 10.1038/s41392-021-00777-z

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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Authors: Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang , Xu Li

Journal: Dev Cell

PubMed ID: 34626540

Doi: 10.1016/j.devcel.2021.09.015

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CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense

Authors: Xue-Peng Li, Guan-Yu Chen, Qiu Jin, Fang-Rui Lou, Bing-Jian Liu, Jian Zhang, Ji-Xing Feng, Tian-Tian Chen

Journal: Int J Biol Macromol

PubMed ID: 34666131

Doi: 10.1016/j.ijbiomac.2021.10.080

Products & Services: Proteins, Expression, Isolation and Analysis

Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Authors: Yan Li, Siyu Shen, Haoran Guo, Zhe Zhang, Lili Zhang, Qingran Yang, Yanhang Gao, Junqi Niu, Wei Wei

Journal: Front Microbiol

PubMed ID: 34733242

Doi: 10.3389/fmicb.2021.706241

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Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Authors: Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34628068

Doi: 10.1016/j.parint.2021.102479

Products & Services: Proteins, Expression, Isolation and Analysis

The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3 Against With No Detectable Resistance

Authors: Depeng Zhu, Fangyi Chen, Yan-Chao Chen, Hui Peng, Ke-Jian Wang

Journal: Front Cell Infect Microbiol

PubMed ID: 34676176

Doi: 10.3389/fcimb.2021.752637

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana

Authors: Tong Zhu, Xue Zhou, Jian-Long Zhang, Wei-Hao Zhang, Li-Pei Zhang, Chun-Xiang You, Paula E Jameson, Peng-Tao Ma, Shan-Li Guo

Journal: Mol Plant Pathol

PubMed ID: 34633738

Doi: 10.1111/mpp.13139

Products & Services: Proteins, Expression, Isolation and Analysis

NORHA, a novel follicular atresia-related lncRNA, promotes porcine granulosa cell apoptosis via the miR-183-96-182 cluster and FoxO1 axis

Authors: Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li

Journal: J Anim Sci Biotechnol

PubMed ID: 34615552

Doi: 10.1186/s40104-021-00626-7

Products & Services: Proteins, Expression, Isolation and Analysis

Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Authors: Poorya Sadeghi, Hessamaddin Sohrabi, Maryam Hejazi, Ali Jahanban-Esfahlan, Behzad Baradaran, Maryam Tohidast, Mir Reza Majidi, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar, Miguel de la Guardia

Journal: Trends Analyt Chem

PubMed ID: 34697511

Doi: 10.1016/j.trac.2021.116460

Products & Services: Proteins, Expression, Isolation and Analysis

Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8 T cells

Authors: Margot Miranda-Katz, John J Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John V Williams

Journal: Sci Rep

PubMed ID: 34675220

Doi: 10.1038/s41598-021-00023-0

Products & Services: Proteins, Expression, Isolation and Analysis

Arabidopsis fibrillin 1-2 subfamily exerts their functions via specific protein-protein interactions

Authors: Diego Torres-Romero, Ángeles Gómez-Zambrano, Antonio Jesús Serrato, Mariam Sahrawy, Ángel Mérida

Journal: J Exp Bot

PubMed ID: 34651644

Doi: 10.1093/jxb/erab452

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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Authors: Kathryn McGuckin Wuertz, Erica K Barkei, Wei-Hung Chen, Elizabeth J Martinez, Ines Lakhal-Naouar, Linda L Jagodzinski, Dominic Paquin-Proulx, Gregory D Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V Thomas, Rajeshwer S Sankhala, Agnes Hajduczki, Caroline E Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F Wood, Jeffrey W Froude, Matthew Gagne, Amy R Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J Krebs, Andrew S Pekosz, Jeffrey R Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G Lewis, Sandhya Vasan, Mehul Suthar, Victoria R Polonis, Gary R Matyas, Eli A Boritz, Daniel C Douek, Robert A Seder, Sharon P Daye, Mangala Rao, Sheila A Peel, M Gordon Joyce, Diane L Bolton, Nelson L Michael, Kayvon Modjarrad

Journal: npj Vaccines

PubMed ID: 34711815

Doi: 10.1038/s41541-021-00392-7

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Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

Authors: Nitzan Tal, Benjamin R Morehouse, Adi Millman, Avigail Stokar-Avihail, Carmel Avraham, Taya Fedorenko, Erez Yirmiya, Ehud Herbst, Alexander Brandis, Tevie Mehlman, Yaara Oppenheimer-Shaanan, Alexander F A Keszei, Sichen Shao, Gil Amitai, Philip J Kranzusch, Rotem Sorek

Journal: Cell

PubMed ID: 34644530

Doi: 10.1016/j.cell.2021.09.031

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Authors: Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton

Journal: Nat Commun

PubMed ID: 34663813

Doi: 10.1038/s41467-021-26239-2

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Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

Authors: Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang

Journal: npj Vaccines

PubMed ID: 34611173

Doi: 10.1038/s41541-021-00382-9

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Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ()

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S Hayward, Paul D Ling

Journal: Microbiol Spectr

PubMed ID: 34668724

Doi: 10.1128/Spectrum.00983-21

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Effects of Distal Mutations on Ligand-Binding Affinity in Dihydrofolate Reductase

Authors: Chen-Hua Huang, Yun-Wen Chen, Tsun-Tsao Huang, Ya-Ting Kao

Journal: ACS Omega

PubMed ID: 34660967

Doi: 10.1021/acsomega.1c02995

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Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Authors: Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Journal: Front Immunol

PubMed ID: 34745083

Doi: 10.3389/fimmu.2021.670338

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Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 2647 macrophages

Authors: Shan Hong, Vermont P Dia, Qixin Zhong

Journal: Int J Biol Macromol

PubMed ID: 34717976

Doi: 10.1016/j.ijbiomac.2021.10.153

Products & Services: Proteins, Expression, Isolation and Analysis

Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein

Authors: Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas W Morrell, Paul D Upton, Carmelo Bernabeu

Journal: Int J Mol Sci

PubMed ID: 34681942

Doi: 10.3390/ijms222011282

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Immune Responses to Orally Administered Recombinant Expressing Multi-Epitope Proteins Targeting M Cells of Foot-and-Mouth Disease Virus

Authors: Fudong Zhang, Zhongwang Zhang, Xian Li, Jiahao Li, Jianliang Lv, Zhongyuan Ma, Li Pan

Journal: Viruses

PubMed ID: 34696469

Doi: 10.3390/v13102036

Products & Services: Proteins, Expression, Isolation and Analysis

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

Authors: David G Alleva, Andrea R Delpero, Melanie M Scully, Sylaja Murikipudi, Ramya Ragupathy, Emma K Greaves, Thillainaygam Sathiyaseelan, Jeffrey R Haworth, Nishit J Shah, Vidhya Rao, Shashikant Nagre, Thomas M Lancaster, Sarah S Webb, Allison I Jasa, Shannon E Ronca, Freedom M Green, Hanne Andersen Elyard, JoAnn Yee, Jeffrey Klein, Larry Karnes, Frans Sollie, Todd C Zion

Journal: Vaccine

PubMed ID: 34642088

Doi: 10.1016/j.vaccine.2021.09.077

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Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses

Authors: Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan

Journal: J Immunol

PubMed ID: 34645689

Doi: 10.4049/jimmunol.2100144

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SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation

Authors: Cristina Mir, Yoelsis Garcia-Mayea, Laia Garcia, Pol Herrero, Nuria Canela, Rocío Tabernero, Juan Lorente, Josep Castellvi, Eva Allonca, Juana García-Pedrero, Juan Pablo Rodrigo, Ángel Carracedo, Matilde Esther LLeonart

Journal: Cancers (Basel)

PubMed ID: 34638436

Doi: 10.3390/cancers13194952

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Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis

Authors: Tao Zhang, Guangquan Zhang, Wenbo Yang, Hongze Chen, Jisheng Hu, Zhongjie Zhao, Chundong Cheng, Guanqun Li, Yu Xie, Yilong Li, Rui Kong, Yongwei Wang, Gang Wang, Hua Chen, Xue-Wei Bai, Shangha Pan, Bei Sun, Le Li

Journal: Cell Death Dis

PubMed ID: 34697288

Doi: 10.1038/s41419-021-04236-z

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Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants

Authors: Haitao Liu, Chenliang Zhou, Jiao An, Yujiao Song, Pin Yu, Jiadai Li, Chenjian Gu, Dongdong Hu, Yuanxiang Jiang, Lingli Zhang, Chuanqi Huang, Chao Zhang, Yunqi Yang, Qianjun Zhu, Dekui Wang, Yuqiang Liu, Chenyang Miao, Xiayao Cao, Longfei Ding, Yuanfei Zhu, Hua Zhu, Linlin Bao, Lingyun Zhou, Huan Yan, Jiang Fan, Jianqing Xu, Zhongyu Hu, Youhua Xie, Jiangning Liu, Ge Liu

Journal: Vaccine

PubMed ID: 34750014

Doi: 10.1016/j.vaccine.2021.10.066

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Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1

Authors: Dongkook Min, Jaemin Byun, Eun-Joon Lee, Abdul A Khan, Christina Liu, Oliver Loudig, Wei Hu, Yong Zhao, Meenhard Herlyn, Benjamin Tycko, Phillip A Cole, Byungwoo Ryu

Journal: Mol Cancer Res

PubMed ID: 34610961

Doi: 10.1158/1541-7786.MCR-21-0289

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The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein

Authors: Yunpeng Sun, Houfang Long, Wencheng Xia, Kun Wang, Xia Zhang, Bo Sun, Qin Cao, Yaoyang Zhang, Bin Dai, Dan Li, Cong Liu

Journal: Nat Commun

PubMed ID: 34716315

Doi: 10.1038/s41467-021-26433-2

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Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Authors: Frank Kozielski, Céleste Sele, Vladimir O Talibov, Jiaqi Lou, Danni Dong, Qian Wang, Xinyue Shi, Maria Nyblom, Annika Rogstam, Tobias Krojer, Zoë Fisher, Wolfgang Knecht

Journal: RSC Chem Biol

PubMed ID: 35128408

Doi: 10.1039/d1cb00135c

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Effect of Amelotin on Bone Growth in the Murine Calvarial Defect Model

Authors: Daiki Tanaka, Yuichi Ikeda, Eri Ikeda, Mako Yokose, Bernhard Ganss, Takanori Iwata

Journal: Ann Biomed Eng

PubMed ID: 34608582

Doi: 10.1007/s10439-021-02867-z

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The Development of Dual Vaccines against Lumpy Skin Disease (LSD) and Bovine Ephemeral Fever (BEF)

Authors: Nicola Douglass, Ruzaiq Omar, Henry Munyanduki, Akiko Suzuki, Warren de Moor, Paidamwoyo Mutowembwa, Alri Pretorius, Tshifhiwa Nefefe, Antoinette van Schalkwyk, Pravesh Kara, Livio Heath, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34835146

Doi: 10.3390/vaccines9111215

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Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression

Authors: Gloria Gamiz-Arco, Valeria A Risso, Eric A Gaucher, Jose A Gavira, Athi N Naganathan, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz

Journal: J Mol Biol

PubMed ID: 34687715

Doi: 10.1016/j.jmb.2021.167321

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Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring

Authors: Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok H De Vos, Jean-Pierre Timmermans, Shunqing Xu, Yaohui Tang, Xia Sheng

Journal: Adv Sci (Weinh)

PubMed ID: 34713618

Doi: 10.1002/advs.202102686

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F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis

Authors: Christopher S Campomizzi, George E Ghanatios, D Fernando Estrada

Journal: J Biol Chem

PubMed ID: 34634307

Doi: 10.1016/j.jbc.2021.101287

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Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants

Authors: Nabangshu Sharma, Ivanhoe K H Leung

Journal: Front Chem

PubMed ID: 34746090

Doi: 10.3389/fchem.2021.711345

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Mdivi-1 Modulates Macrophage/Microglial Polarization in Mice with EAE via the Inhibition of the TLR2/4-GSK3β-NF-κB Inflammatory Signaling Axis

Authors: Xiaoqin Liu, Xiaojuan Zhang, Xiaojie Niu, Peijun Zhang, Qing Wang, Xiuhua Xue, Guobin Song, Jiezhong Yu, Guoping Xi, Lijuan Song, Yanhua Li, Cungen Ma

Journal: Mol Neurobiol

PubMed ID: 34618332

Doi: 10.1007/s12035-021-02552-1

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A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiation

Authors: Pengjie Hu, Hao Ding, Lan Shen, Guang-Jun He, Huimin Liu, Xiuyun Tian, Changyu Tao, Xiangzheng Bai, Jingnan Liang, Cheng Jin, Xinping Xu, Ence Yang, Linqi Wang

Journal: PLoS Genet

PubMed ID: 34624015

Doi: 10.1371/journal.pgen.1009817

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Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Authors: Jiajia Wang, Jiaying Wang, Wenxiang Hong, Lulu Zhang, Liqian Song, Qi Shi, Yanfei Shao, Guifeng Hao, Chunyan Fang, Yueping Qiu, Lijun Yang, Zhaoxu Yang, Jincheng Wang, Ji Cao, Bo Yang, Qiaojun He, Qinjie Weng

Journal: Nat Commun

PubMed ID: 34707127

Doi: 10.1038/s41467-021-26477-4

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Non-canonical activation of the ER stress sensor ATF6 by effectors

Authors: Nnejiuwa U Ibe, Advait Subramanian, Shaeri Mukherjee

Journal: Life Sci Alliance

PubMed ID: 34635501

Doi: 10.26508/lsa.202101247

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Authors: Lorenzo Gamberini, Carlo Alberto Mazzoli, Irene Prediletto, Harri Sintonen, Gaetano Scaramuzzo, Davide Allegri, Davide Colombo, Tommaso Tonetti, Gianluca Zani, Chiara Capozzi, Giorgia Dalpiaz, Vanni Agnoletti, Iacopo Cappellini, Gabriele Melegari, Federica Damiani, Maurizio Fusari, Giovanni Gordini, Cristiana Laici, Maria Concetta Lanza, Mirco Leo, Andrea Marudi, Raffaella Papa, Antonella Potalivo, Jonathan Montomoli, Stefania Taddei, Massimiliano Mazzolini, Anna Filomena Ferravante, Roberta Nicali, Vito Marco Ranieri, Emanuele Russo, Carlo Alberto Volta, Savino Spadaro

Journal: Respir Med

PubMed ID: 34717097

Doi: 10.1016/j.rmed.2021.106665

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Persistence of antibody and T cell responses to the Sinopharm/BBIBP-CorV vaccine in Sri Lankan individuals

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathne, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: medrxiv

PubMed ID: 34704105

Doi: 10.1101/2021.10.14.21265030

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Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans

Authors: Camilla S Kristensen, Anders K Varming, Helena A K Leinweber, Karin Hammer, Leila Lo Leggio, Hanne Ingmer, Mogens Kilstrup

Journal: Microbiologyopen

PubMed ID: 34713608

Doi: 10.1002/mbo3.1245

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The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

Authors: Chun-Hao Su, Wei-Ju Liao, Wei-Chi Ke, Ruey-Bing Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34816104

Doi: 10.1016/j.isci.2021.103368

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S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Authors: Francisco S Mesquita, Laurence Abrami, Oksana Sergeeva, Priscilla Turelli, Enya Qing, Béatrice Kunz, Charlène Raclot, Jonathan Paz Montoya, Luciano A Abriata, Tom Gallagher, Matteo Dal Peraro, Didier Trono, Giovanni D'Angelo, F Gisou van der Goot

Journal: Dev Cell

PubMed ID: 34599882

Doi: 10.1016/j.devcel.2021.09.016

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Structural determinants of the integrin transmembrane domain required for bidirectional signal transmission across the cell membrane

Authors: Zhengli Wang, Jieqing Zhu

Journal: J Biol Chem

PubMed ID: 34678312

Doi: 10.1016/j.jbc.2021.101318

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Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

Authors: Xuezhi Cao, Yong Liang, Zhenxiang Hu, Huiyu Li, Jiaming Yang, Eric J Hsu, Jiankun Zhu, Jin Zhou, Yang-Xin Fu

Journal: Nat Commun

PubMed ID: 34620867

Doi: 10.1038/s41467-021-26112-2

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The GPR171 pathway suppresses T cell activation and limits antitumor immunity

Authors: Yuki Fujiwara, Robert J Torphy, Yi Sun, Emily N Miller, Felix Ho, Nicholas Borcherding, Tuoqi Wu, Raul M Torres, Weizhou Zhang, Richard D Schulick, Yuwen Zhu

Journal: Nat Commun

PubMed ID: 34615877

Doi: 10.1038/s41467-021-26135-9

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Complete three-dimensional structures of the Lon protease translocating a protein substrate

Authors: Shanshan Li, Kan-Yen Hsieh, Chiao-I Kuo, Szu-Hui Lee, Grigore D Pintilie, Kaiming Zhang, Chung-I Chang

Journal: Sci Adv

PubMed ID: 34652947

Doi: 10.1126/sciadv.abj7835

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Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic

Authors: Aysun Yilmaz, Abdullah Kayar, Nuri Turan, Onur Iskefli, Alper Bayrakal, Gleyder Roman-Sosa, Erman Or, Hasan Emre Tali, Bekir Kocazeybek, Ridvan Karaali, Dashzeveg Bold, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Munir Iqbal, Juergen A Richt, Huseyin Yilmaz

Journal: Front Vet Sci

PubMed ID: 34712718

Doi: 10.3389/fvets.2021.707368

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A Novel Brighter Bioluminescent Fusion Protein Based on ZZ Domain and Firefly Luciferase for Immunoassays

Authors: Vadim R Viviani, Jaqueline Rodrigues Silva, Paulo Lee Ho

Journal: Front Bioeng Biotechnol

PubMed ID: 34733833

Doi: 10.3389/fbioe.2021.755045

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VpreB Surrogate Light Chain Expression in B-Lineage ALL: A Report from the Children's Oncology Group

Authors: Stuart Sheldon Winter, Amanda McCaustland, Chunxu Qu, No'eau Simeona, Nyla A Heerema, Andrew J Carroll, Brent L Wood, Gabriela Gheorghe, Charles G Mullighan, Bridget S Wilson

Journal: Blood Adv

PubMed ID: 34662891

Doi: 10.1182/bloodadvances.2021005245

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The colorful mantle of the giant clam Tridacna squamosa expresses a homolog of electrogenic sodium: Bicarbonate cotransporter 2 that mediates the supply of inorganic carbon to photosynthesizing symbionts

Authors: Mel V Boo, Shit F Chew, Yuen K Ip

Journal: PLoS ONE

PubMed ID: 34653199

Doi: 10.1371/journal.pone.0258519

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A Portable RT-LAMP/CRISPR Machine for Rapid COVID-19 Screening

Authors: Meysam Rezaei, Sajad Razavi Bazaz, Dorsa Morshedi Rad, Olga Shimoni, Dayong Jin, William Rawlinson, Majid Ebrahimi Warkiani

Journal: Biosensors (Basel)

PubMed ID: 34677325

Doi: 10.3390/bios11100369

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A New Light on Potential Therapeutic Targets for Colorectal Cancer Treatment

Authors: Wei-Lun Tsai, Chih-Yang Wang, Yu-Cheng Lee, Wan-Chun Tang, Gangga Anuraga, Hoang Dang Khoa Ta, Yung-Fu Wu, Kuen-Haur Lee

Journal: Biomedicines

PubMed ID: 34680556

Doi: 10.3390/biomedicines9101438

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Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway

Authors: Yong Luo, Xiaobing Yang, Spyridon P Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jiang

Journal: Front Mol Biosci

PubMed ID: 34746227

Doi: 10.3389/fmolb.2021.652443

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miR-29a-3p promotes migration and invasion in ameloblastoma via Wnt/β-catenin signaling by targeting catenin beta interacting protein 1

Authors: Sai Liu, Dongjuan Liu, Jinwen Liu, Jiayi Liu, Ming Zhong

Journal: Head Neck

PubMed ID: 34636093

Doi: 10.1002/hed.26888

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