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Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Case

Authors: Enrico König, Assunta Gagliardi, Ilary Riedmiller, Chiara Andretta, Michele Tomasi, Carmela Irene, Luca Frattini, Ilaria Zanella, Francesco Berti, Alberto Grandi, Elena Caproni, Laura Fantappiè, Guido Grandi

Journal: Front Immunol

PubMed ID: 34819933

Doi: 10.3389/fimmu.2021.752168

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Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy

Authors: Jun Zheng, Xi Chen, Qiang Liu, Guisheng Zhong, Min Zhuang

Journal: J Cell Biol

PubMed ID: 34747980

Doi: 10.1083/jcb.202103156

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Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice

Authors: Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou, Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J Bäumler, Cheng-Yuan Kao

Journal: Cell Rep

PubMed ID: 34818535

Doi: 10.1016/j.celrep.2021.110016

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Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains*

Authors: Karen T Elvers, Magdalena Lipka-Lloyd, Rebecca C Trueman, Benjamin D Bax, Youcef Mehellou

Journal: Chembiochem

PubMed ID: 34726826

Doi: 10.1002/cbic.202100441

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Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Authors: Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang

Journal: Endocr Connect

PubMed ID: 34678757

Doi: 10.1530/EC-21-0179

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Structure of Rift Valley fever virus RNA-dependent RNA polymerase

Authors: Xue Wang, Cuixia Hu, Wei Ye, Jia Wang, Xiaofei Dong, Jie Xu, Xiaorong Li, Manfeng Zhang, Hongyun Lu, Fanglin Zhang, Wei Wu, Shaodong Dai, Hong-Wei Wang, Zhongzhou Chen

Journal: J Virol

PubMed ID: 34787453

Doi: 10.1128/JVI.01713-21

Products & Services: Proteins, Expression, Isolation and Analysis

Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease

Authors: Sukanya Srinivasan, Jozsef Gal, Adam Bachstetter, Peter T Nelson

Journal: Neuropathol Appl Neurobiol

PubMed ID: 34820873

Doi: 10.1111/nan.12776

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ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca in Spodoptera litura

Authors: Xue Yao, Chen Liu, Yunpeng Duan, Shiheng An, Jizhen Wei, Gemei Liang

Journal: Int J Biol Macromol

PubMed ID: 34861271

Doi: 10.1016/j.ijbiomac.2021.11.174

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Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides

Authors: Maria Carmina Scala, Simone Di Micco, Delia Lanzillotta, Simona Musella, Veronica Di Sarno, Barbara Parrino, Stella Maria Casciofierro, Giuseppe Bifulco, Francesco Trapasso, Pietro Campiglia, Marina Sala

Journal: Front Mol Biosci

PubMed ID: 34901149

Doi: 10.3389/fmolb.2021.715263

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Molecular characterization of substrate-induced ubiquitin transfer by UBR7-PHD finger, a newly identified histone H2BK120 ubiquitin ligase

Authors: Anirban Dasgupta, Payel Mondal, Sambit Dalui, Chandrima Das, Siddhartha Roy

Journal: FEBS J

PubMed ID: 34739193

Doi: 10.1111/febs.16262

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Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Authors: Eline van Diest, Patricia Hernández López, Angelo D Meringa, Anna Vyborova, Froso Karaiskaki, Sabine Heijhuurs, Jan Gumathi Bormin, Sanne van Dooremalen, Mara J T Nicolasen, Lucrezia C D E Gatti, Inez Johanna, Trudy Straetemans, Zsolt Sebestyén, Dennis X Beringer, Jürgen Kuball

Journal: J Immunother Cancer

PubMed ID: 34815357

Doi: 10.1136/jitc-2021-003850

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The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid

Authors: Anton A Stepnov, Idd A Christensen, Zarah Forsberg, Finn L Aachmann, Gaston Courtade, Vincent G H Eijsink

Journal: FEBS Lett

PubMed ID: 34845720

Doi: 10.1002/1873-3468.14246

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Structural characterization of the porcine adeno-associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha

Authors: Mikayla Hoad, Justin A Roby, Jade K Forwood

Journal: FEBS Lett

PubMed ID: 34661283

Doi: 10.1002/1873-3468.14209

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A simple PCR-RFLP method for identification and detection of medicinal toad and its crude drug even with serious degradation of DNA

Authors: Jiao Liu, Xinyi Shao, Ziying Zhou, Miao Lei, Mingyu Xia, Dong Wang

Journal: J Pharm Biomed Anal

PubMed ID: 34864355

Doi: 10.1016/j.jpba.2021.114495

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1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells

Authors: Yanqi Li, Ping Deng, Chunhai Chen, Qinlong Ma, Huifeng Pi, Mindi He, Yonghui Lu, Peng Gao, Chao Zhou, Zhixin He, Yanwen Zhang, Zhengping Yu, Lei Zhang

Journal: Front Public Health

PubMed ID: 34881219

Doi: 10.3389/fpubh.2021.771508

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Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Authors: Cristina Gil-Cruz, Christian Perez-Shibayama, Angelina De Martin, Francesca Ronchi, Katrien van der Borght, Rebekka Niederer, Lucas Onder, Mechthild Lütge, Mario Novkovic, Veronika Nindl, Gustavo Ramos, Markus Arnoldini, Emma M C Slack, Valérie Boivin-Jahns, Roland Jahns, Madeleine Wyss, Catherine Mooser, Bart N Lambrecht, Micha T Maeder, Hans Rickli, Lukas Flatz, Urs Eriksson, Markus B Geuking, Kathy D McCoy, Burkhard Ludewig

Journal: Science

PubMed ID: 31727837

Doi: 10.1126/science.aav3487

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Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

Authors: Haiyan Hong, Zilong Guo, Hao Sun , Ping Yu , Huanhuan Su , Xuening Ma & Hu Chen

Journal: Communications Chemistry

Doi: doi.org/10.1038/s42004-021-00592-1

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Performance Evaluation of the BZ COVID-19 Neutralizing Antibody Test for the Culture-Free and Rapid Detection of SARS-CoV-2 Neutralizing Antibodies

Authors: Bo Kyeung Jung, Jung Yoon, Joon-Yong Bae, Jeonghun Kim, Man-Seong Park, Suk Yong Lee, Chae Seung Lim

Journal: Diagnostics (Basel)

PubMed ID: 34943430

Doi: 10.3390/diagnostics11122193

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Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein

Authors: Hristo L Svilenov, Julia Sacherl, Alwin Reiter, Lisa S Wolff, Cho-Chin Cheng, Marcel Stern, Vincent Grass, Martin Feuerherd, Frank-Peter Wachs, Nicole Simonavicius, Susanne Pippig, Florian Wolschin, Oliver T Keppler, Johannes Buchner, Carsten Brockmeyer, Ulrike Protzer

Journal: Antiviral Res

PubMed ID: 34774603

Doi: 10.1016/j.antiviral.2021.105197

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Kinetics of anti-SARS-CoV-2 neutralizing antibodies development after BNT162b2 vaccination in patients with amyloidosis and the impact of therapy

Authors: Efstathios Kastritis, Evangelos Terpos, Zoi Evangelakou, Foteini Theodorakakou, Despina Fotiou, Maria S Manola, Despoina D Gianniou, Tina Bagratuni, Nikolaos Kanellias, Magdalini Migkou, Maria Gavriatopoulou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Am J Hematol

PubMed ID: 34778995

Doi: 10.1002/ajh.26406

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Backbone H, N, and C resonance assignments of the non-structural protein NS2B of Zika virus

Authors: Beatriz Rosa Penna, Danielle Maria P de Oliveira, Cristiane Dinis Anobom, Ana Paula Valente

Journal: Biomol NMR Assign

PubMed ID: 34817802

Doi: 10.1007/s12104-021-10055-2

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JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

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Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses

Authors: Vijaya L Simhadri, Joseph R McGill, Zuben E Sauna

Journal: Gene Ther

PubMed ID: 34744169

Doi: 10.1038/s41434-021-00301-6

Products & Services: Proteins, Expression, Isolation and Analysis

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Authors: Jill P Smith, Hong Cao, Elijah F Edmondson, Siva Sai Krishna Dasa, Stephan T Stern

Journal: Biomolecules

PubMed ID: 34944412

Doi: 10.3390/biom11121766

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Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus

Authors: Mintu Chandra, Brett M Collins, Lauren P Jackson

Journal: Adv Biol Regul

PubMed ID: 34866035

Doi: 10.1016/j.jbior.2021.100842

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Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy

Authors: Sheng-Li Ming , Shuang Zhang , Qi Wang , Lei Zeng , Lu-Yu Zhou , Meng-Di Wang , Ying-Xian Ma , Li-Qiang Han , Kai Zhong , He-Shui Zhu , Yi-Lin Bai , Guo-Yu Yang , Jiang Wang , Bei-Bei Chu

Journal: Autophagy

PubMed ID: 34822318

Doi: 10.1080/15548627.2021.2002101

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Novel xylan-degrading enzymes from polysaccharide utilizing loci of Prevotella copri DSM18205

Authors: Javier A Linares-Pastén , Johan Sebastian Hero , José Horacio Pisa , Cristina Teixeira , Margareta Nyman , Patrick Adlercreutz , M Alejandra Martinez , Eva Nordberg Karlsson

Journal: Glycobiology

PubMed ID: 34142143

Doi: 10.1093/glycob/cwab056

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Phylogenetic Analysis of the Plant U2 snRNP Auxiliary Factor Large Subunit A Gene Family in Response to Developmental Cues and Environmental Stimuli

Authors: Shuai Lu, Cong Gao, Yongzhou Wang, Yingying He, Junrong Du, Moxian Chen, Hua Zhao, Hui Fang, Baohua Wang, Yunying Cao

Journal: Front Plant Sci

PubMed ID: 34868124

Doi: 10.3389/fpls.2021.739671

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Wilavidin - a novel member of the avidin family that forms unique biotin-binding hexamers

Authors: Orly Avraham, Edward A Bayer, Oded Livnah

Journal: FEBS J

PubMed ID: 34726340

Doi: 10.1111/febs.16259

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Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

Authors: Matthew McCallum, Alexandra C Walls, Kaitlin R Sprouse, John E Bowen, Laura E Rosen, Ha V Dang, Anna De Marco, Nicholas Franko, Sasha W Tilles, Jennifer Logue, Marcos C Miranda, Margaret Ahlrichs, Lauren Carter, Gyorgy Snell, Matteo Samuele Pizzuto, Helen Y Chu, Wesley C Van Voorhis, Davide Corti, David Veesler

Journal: Science

PubMed ID: 34751595

Doi: 10.1126/science.abl8506

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Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka

Authors: Chandima Jeewandara, Dinuka Guruge, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Inoka Sepali Aberathna, Shyrar Tanussiya Ramu, Banuri Gunasekera, Ayesha Wijesinghe, Osanda Dissanayake, Heshan Kuruppu, Thushali Ranasinghe, Deshni Jayathilaka, Shashika Dayarathna, Dinithi Ekanayake, Jeewantha Jayamali, Nayanathara Gamalath, Anushika Mudunkotiwa, Gayasha Somathilake, Madhushika Dissanayake, Michael Harvie, Thashmi Nimasha, Deshan Madusanka, Tibutius Jayadas, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: J Immunol

PubMed ID: 34750205

Doi: 10.4049/jimmunol.2100762

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α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-β-catenin pathway

Authors: Zewu Zhu, Shuhao Ruan, Yingcheng Jiang, Fang Huang, Weiping Xia, Jinbo Chen, Yu Cui, Cheng He, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen

Journal: Cell Mol Life Sci

PubMed ID: 34724098

Doi: 10.1007/s00018-021-03972-x

Products & Services: Proteins, Expression, Isolation and Analysis

Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation

Authors: Thaiesha A Wright, Monica Sharfin Rahman, Camaryn Bennett, Madolynn R Johnson, Henry Fischesser, Natasha Ram, Amoni Tyler, Richard C Page, Dominik Konkolewicz

Journal: Bioconjug Chem

PubMed ID: 34730954

Doi: 10.1021/acs.bioconjchem.1c00487

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LDH nanoparticle adjuvant subunit vaccine induces an effective immune response for porcine epidemic diarrhea virus

Authors: Danyi Shi, Baochao Fan, Bing Sun, Jinzhu Zhou, Yongxiang Zhao, Rongli Guo, Zengjun Ma, Tao Song, Huiying Fan, Jizong Li, Li Li, Bin Li

Journal: Virology

PubMed ID: 34739917

Doi: 10.1016/j.virol.2021.10.010

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Polyactin A and CpG enhance inactivated Pseudomonas plecoglossicida vaccine potency in large yellow croaker (Larimichthys crocea)

Authors: Wenwen Wang, Wei Wang, Wenjun Xu, Qin Liu, Yuanxing Zhang, Xiaohong Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34780977

Doi: 10.1016/j.fsi.2021.11.008

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STING inhibition accelerates the bone healing process while enhancing type H vessel formation

Authors: Xiaojun Chen, Wenxin He, Mengzhe Sun, Yingjie Yan, Yichuan Pang, Gang Chai

Journal: FASEB J

PubMed ID: 34694030

Doi: 10.1096/fj.202100069RR

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Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

Authors: Kamela O Alegre, Navid Paknejad, Minfei Su, Jian-Shu Lou, Jianyun Huang, Kelsey D Jordan, Edward T Eng, Joel R Meyerson, Richard K Hite, Xin-Yun Huang

Journal: Nat Struct Mol Biol

PubMed ID: 34759376

Doi: 10.1038/s41594-021-00679-2

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Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway

Authors: Yue Shi, Chong Liu

Journal: BMC Cancer

PubMed ID: 34800978

Doi: 10.1186/s12885-021-08989-w

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Mapping enzyme catalysis with metabolic biosensing

Authors: Linfeng Xu, Kai-Chun Chang, Emory M Payne, Cyrus Modavi, Leqian Liu, Claire M Palmer, Nannan Tao, Hal S Alper, Robert T Kennedy, Dale S Cornett, Adam R Abate

Journal: Nat Commun

PubMed ID: 34815408

Doi: 10.1038/s41467-021-27185-9

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SpSR-B2 functions as a potential pattern recognition receptor involved in antiviral and antibacterial immune responses of mud crab Scylla paramamosain

Authors: Jian Zhou, Jun-Fang Zhou, Yue Wang, Guang-Peng Feng, Wen-Hong Fang, Wei Kang, Ling-Bo Ma, Xin-Cang Li

Journal: Int J Biol Macromol

PubMed ID: 34780895

Doi: 10.1016/j.ijbiomac.2021.11.048

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Photoredox-Catalyzed Decarboxylative -Terminal Differentiation for Bulk- and Single-Molecule Proteomics

Authors: Le Zhang, Brendan M Floyd, Maheshwerreddy Chilamari, James Mapes, Jagannath Swaminathan, Steven Bloom, Edward M Marcotte, Eric V Anslyn

Journal: ACS Chem Biol

PubMed ID: 34734691

Doi: 10.1021/acschembio.1c00631

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Elevated Fab glycosylation of anti-hinge antibodies

Authors: J Koers, Nil Derksen, Wjj Falkenburg, P Ooijevaar-de Heer, M T Nurmohamed, G J Wolbink, T Rispens

Journal: Scand J Rheumatol

PubMed ID: 34726124

Doi: 10.1080/03009742.2021.1986959

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Using recombinant adhesive proteins as durable and green flame-retardant coatings

Authors: Weng I Leong, Owen Lok In Lo, Fong Tin Cheng, Wai Man Cheong, Leo Chi U Seak

Journal: Synth Syst Biotechnol

PubMed ID: 34786512

Doi: 10.1016/j.synbio.2021.10.005

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Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved in -Terphenyl Biosynthesis

Authors: Jonathan A Clinger, Yinan Zhang, Yang Liu, Mitchell D Miller, Ronnie E Hall, Steven G Van Lanen, George N Phillips, Jon S Thorson, Sherif I Elshahawi

Journal: ACS Chem Biol

PubMed ID: 34763417

Doi: 10.1021/acschembio.1c00701

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Biodegradation of diphenyl ether herbicide lactofen by Bacillus sp YS-1 and characterization of two initial degrading esterases

Authors: Na Shang, Lingling Chen, Minggen Cheng, Yanning Tian, Xing Huang

Journal: Sci Total Environ

PubMed ID: 34742792

Doi: 10.1016/j.scitotenv.2021.151357

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Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

Authors: Deepali Gupta, Priyanka Sharma, Mandeep Singh, Mukesh Kumar, A S Ethayathulla, Punit Kaur

Journal: Cell Mol Life Sci

PubMed ID: 34731254

Doi: 10.1007/s00018-021-04008-0

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Prokaryotic expression, evaluation, and prediction of the structure and function of the ecarin metalloproteinase domain

Authors: Nasrin Mohammadi, Mojgan Bandehpour, Fattah Sotoodehnejadnematalahi, Bahram Kazemi

Journal: Proteins

PubMed ID: 34739152

Doi: 10.1002/prot.26275

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African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis

Authors: Tingting Li, Gaihong Zhao, Taoqing Zhang, Zhaoxia Zhang, Xin Chen, Jie Song, Xiao Wang, Jiangnan Li, Li Huang, Lili Wen, Changyao Li, Dongming Zhao, Xijun He, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: Viruses

PubMed ID: 34835046

Doi: 10.3390/v13112240

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5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos

Authors: Luxi Chen, Wei Xu, Kunpeng Liu, Zheng Jiang, Yang Han, Hongbin Jin, Lin Zhang, Weimin Shen, Shunji Jia, Qianwen Sun, Anming Meng

Journal: Sci Adv

PubMed ID: 34797706

Doi: 10.1126/sciadv.abh0494

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Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway

Authors: Xiaohan Luan, Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun

Journal: FASEB J

PubMed ID: 34606626

Doi: 10.1096/fj.202101044RRR

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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA

Authors: Alicia K Byrd, Emory G Malone, Lindsey Hazeslip, Maroof Khan Zafar, David K Harrison, Matthew D Thompson, Jun Gao, Senthil K Perumal, John C Marecki, Kevin D Raney

Journal: Protein Sci

PubMed ID: 34761452

Doi: 10.1002/pro.4232

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Identification and Characterization of Antigen-Specific CD8 T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing

Authors: Shaheed Abdulhaqq, Abigail B Ventura, Jason S Reed, Arman A Bashirova, Katherine B Bateman, Eric McDonald, Helen L Wu, Justin M Greene, John B Schell, David Morrow, Karin Wisskirchen, Jeffrey N Martin, Steven G Deeks, Mary Carrington, Ulrike Protzer, Klaus Früh, Scott G Hansen, Louis J Picker, Jonah B Sacha, Benjamin N Bimber

Journal: J Immunol

PubMed ID: 34810222

Doi: 10.4049/jimmunol.2100535

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The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States

Authors: Andrew Bogard, Pangaea W Finn, Fulton McKinney, Ilinca M Flacau, Aviana R Smith, Rosey Whiting, Daniel Fologea

Journal: Membranes (Basel)

PubMed ID: 34832126

Doi: 10.3390/membranes11110897

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SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Authors: Jesse D Deere, Timothy D Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L Yee, Katherine J Olstad, J Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Graham Simmons, Jennifer Watanabe, Rachel E Pollard, Jodie Usachenko, Ramya Immareddy, Brian A Schmidt, Shelby L O'Connor, Joseph DeRisi, Michael P Busch, Smita S Iyer, Koen K A Van Rompay, Dennis J Hartigan-O'Connor, Christopher J Miller

Journal: Microbiol Spectr

PubMed ID: 34817208

Doi: 10.1128/Spectrum.01397-21

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Retinol-Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3

Authors: Kang-Zhen Zhang, Xi-Yu Shen, Man Wang, Li Wang, Hui-Xian Sun, Xiu-Zhen Li, Jing-Jing Huang, Xiao-Qing Li, Cheng Wu, Can Zhao, Jia-Li Liu, Xiang Lu, Wei Gao

Journal: J Am Heart Assoc

PubMed ID: 34726071

Doi: 10.1161/JAHA.121.022011

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Management of COVID patients with convalescent plasma: Do we have the final word?

Authors: Francesco Menichetti, Marco Falcone, Giusy Tiseo

Journal: Eur J Intern Med

PubMed ID: 34895816

Doi: 10.1016/j.ejim.2021.10.029

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A study of cobalt (II) complexes involved in marine biogeochemical processes: Co(II)-1,10-Phenanthroline and Co(II)-1,10-Phenanthroline-L-α-Phosphatidylcholine

Authors: Anđela Bačinić, Sanja Frka, Marina Mlakar

Journal: Bioelectrochemistry

PubMed ID: 34902665

Doi: 10.1016/j.bioelechem.2021.108009

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Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies

Authors: Anilkumar Gopalakrishnapillai, Colin E Correnti, Kristina Pilat, Ida Lin, Man Kid Chan, Ashok D Bandaranayake, Christopher Mehlin, Anne Kisielewski, Darcy Hamill, Allison J Kaeding, Soheil Meshinchi, James M Olson, Edward Anders Kolb, Sonali P Barwe

Journal: Cancers (Basel)

PubMed ID: 34885074

Doi: 10.3390/cancers13235964

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Overexpression of N-acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation

Authors: Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou

Journal: J Cell Physiol

PubMed ID: 34806177

Doi: 10.1002/jcp.30641

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleic Acid Delivery from Granular Hydrogels

Authors: Evan Kurt, Tatiana Segura

Journal: Adv Healthc Mater

PubMed ID: 34742164

Doi: 10.1002/adhm.202101867

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates

Authors: Marco Raabe, Astrid Johanna Heck, Siska Führer, Dominik Schauenburg, Michaela Pieszka, Tao Wang, Maksymilian Marek Zegota, Lutz Nuhn, David Y W Ng, Seah Ling Kuan, Tanja Weil

Journal: Macromol Biosci

PubMed ID: 34791790

Doi: 10.1002/mabi.202100299

Products & Services: Proteins, Expression, Isolation and Analysis

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

Authors: Juan Luis Pacheco-Garcia, Dmitry Loginov, Bruno Rizzuti, Pavla Vankova, Jose L Neira, Daniel Kavan, Noel Mesa-Torres, Rita Guzzi, Petr Man, Angel L Pey

Journal: FEBS Lett

PubMed ID: 34817874

Doi: 10.1002/1873-3468.14238

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Genomic structure, expression, and functional characterization of the Fem-1 gene family in the redclaw crayfish, Cherax quadricarinatus

Authors: Jianbo Zheng, Leran Chen, Yongyi Jia, Meili Chi, Fei Li, Shun Cheng, Shili Liu, Yinuo Liu, Zhimin Gu

Journal: Gen Comp Endocrinol

PubMed ID: 34861280

Doi: 10.1016/j.ygcen.2021.113961

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Commensal Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines

Authors: Michele Tomasi, Mattia Dalsass, Francesco Beghini, Ilaria Zanella, Elena Caproni, Laura Fantappiè, Assunta Gagliardi, Carmela Irene, Enrico König, Luca Frattini, Giulia Masetti, Samine Jessica Isaac, Federica Armanini, Fabio Cumbo, Aitor Blanco-Míguez, Alberto Grandi, Nicola Segata, Guido Grandi

Journal: Vaccines (Basel)

PubMed ID: 34835287

Doi: 10.3390/vaccines9111356

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Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Authors: Marcel V Alavi

Journal: Biochim Biophys Acta Mol Cell Res.

PubMed ID: 34400172

Doi: 10.1016/j.bbamcr.2021.119116

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Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Authors: Sai Shashank Chavali, Sachitanand M Mali, Rachel Bonn, Abhijith Saseendran Anitha, Ryan P Bennett, Harold C Smith, Rudi Fasan, Joseph E Wedekind

Journal: J Biol Chem.

PubMed ID: 34767799

Doi: 10.1016/j.jbc.2021.101390

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Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Authors: Martin J Fossat, Ammon E Posey, Rohit V Pappu

Journal: Biophys J

PubMed ID: 34826385

Doi: 10.1016/j.bpj.2021.11.2886

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Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma

Authors: Ai-Ai Luan, Ling-Ling Hou, Fang-Yuan Zhang

Journal: Kaohsiung J Med Sci

PubMed ID: 34850542

Doi: 10.1002/kjm2.12479

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Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha

Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen

Journal: J Stroke Cerebrovasc Dis

PubMed ID: 34837757

Doi: 10.1016/j.jstrokecerebrovasdis.2021.106221

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The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells

Authors: Takwa S Aroankins, Sathish K Murali, Robert A Fenton, Qi Wu

Journal: Front Mol Biosci

PubMed ID: 34881291

Doi: 10.3389/fmolb.2021.790606

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Characterization of the interaction domains between the phosphoprotein and the nucleoprotein of human Metapneumovirus

Authors: Hortense Decool, Benjamin Bardiaux, Luis Checa Ruano, Olivier Sperandio, Jenna Fix, Irina Gutsche, Charles-Adrien Richard, Monika Bajorek, Jean-François Eléouët, Marie Galloux

Journal: J Virol

PubMed ID: 34730389

Doi: 10.1128/JVI.00909-21

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Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow

Authors: Kyong Hoon Kim, Aryeong Choi, Sang Hoon Kim, Heonju Song, Seohoon Jin, Kyungim Kim, Jaebong Jang, Hanbyeul Choi, Yong Woo Jung

Journal: Mol Cells

PubMed ID: 34819396

Doi: 10.14348/molcells.2021.0137

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Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia

Authors: Ting Zhu, Bo Liu, Di Wu, Gang Xu, Yang Fan

Journal: Front Cell Dev Biol

PubMed ID: 34869326

Doi: 10.3389/fcell.2021.740884

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A poly(ethylene glycol) three-dimensional bone marrow hydrogel

Authors: Lauren E Jansen, Hyuna Kim, Christopher L Hall, Thomas P McCarthy, Michael J Lee, Shelly R Peyton

Journal: Biomaterials

PubMed ID: 34890973

Doi: 10.1016/j.biomaterials.2021.121270

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Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

Authors: Ria Goswami, Veronica S Russell, Joshua J Tu, Charlene Thomas, Philip Hughes, Francine Kelly, Stephanie N Langel, Justin Steppe, Scott M Palmer, Timothy Haystead, Maria Blasi, Sallie R Permar

Journal: iScience

PubMed ID: 34786537

Doi: 10.1016/j.isci.2021.103412

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Fabrication of MERS-nanovesicle biosensor composed of multi-functional DNA aptamer/graphene-MoS nanocomposite based on electrochemical and surface-enhanced Raman spectroscopy

Authors: Gahyeon Kim, Jinmyeong Kim, Soo Min Kim, Tatsuya Kato, Jinho Yoon, Seungwoo Noh, Enoch Y Park, Chulhwan Park, Taek Lee, Jeong-Woo Choi

Journal: Sens Actuators B Chem

PubMed ID: 34785863

Doi: 10.1016/j.snb.2021.131060

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Genome-wide identification and characteristic analysis of the downstream melatonin metabolism gene GhM2H in Gossypium hirsutum L

Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei, Wuwei Ye

Journal: Biol Res

PubMed ID: 34736526

Doi: 10.1186/s40659-021-00358-y

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LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

Authors: Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Perez Gutierrez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K Wang, Napoleone Ferrara

Journal: EMBO Mol Med

PubMed ID: 34779136

Doi: 10.15252/emmm.202114511

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Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Authors: Yuan Tian, Yi Wang, Angela M Jablonski, Yinghui Hu, Jonathan A Sugam, Markus Koglin, Shawn J Stachel, Heather Zhou, Jason M Uslaner, Sophie Parmentier-Batteur

Journal: Neurobiol Dis

PubMed ID: 34752923

Doi: 10.1016/j.nbd.2021.105548

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Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation

Authors: Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang

Journal: Protein Cell

PubMed ID: 34731408

Doi: 10.1007/s13238-021-00884-1

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Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway

Authors: Zi-Tan Peng, Pei Gu

Journal: Hum Exp Toxicol

PubMed ID: 34749521

Doi: 10.1177/09603271211054437

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Biosynthesis of Poly(3HB--3HP) with Variable Monomer Composition in Recombinant H16

Authors: Callum McGregor, Nigel P Minton, Katalin Kovács

Journal: ACS Synth Biol

PubMed ID: 34762808

Doi: 10.1021/acssynbio.1c00283

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A Genome-Phenome Association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

Authors: Weiwei Yang, Yu-Cheng Lin, William Johnson, Nan Dai, Romualdas Vaisvila, Peter Weigele, Yan-Jiun Lee, Ivan R Corrêa, Ira Schildkraut, Laurence Ettwiller

Journal: Elife

PubMed ID: 34747693

Doi: 10.7554/eLife.70021

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Poor neutralizing antibody responses in 106 patients with WM after vaccination against SARS-CoV-2: a prospective study

Authors: Maria Gavriatopoulou, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Panagiotis Malandrakis, Despina Fotiou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Blood Adv

PubMed ID: 34529762

Doi: 10.1182/bloodadvances.2021005444

The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome

Authors: Yanqiu Yue, Fengbin Jin, Xiaohui Yue

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 34933712

Doi: 10.14715/cmb/2021.67.3.28

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SNHG17, as an EMT-related lncRNA, promotes the expression of c-Myc by binding to c-Jun in esophageal squamous cell carcinoma

Authors: Supeng Shen, Jia Liang, Xiaoliang Liang, Gaoyan Wang, Bo Feng, Wei Guo, Yanli Guo, Zhiming Dong

Journal: Cancer Sci

PubMed ID: 34714590

Doi: 10.1111/cas.15184

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Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells

Authors: Wei Li, Yanqiu Zhang, Jifeng Xu, Jincan Chen, Xia Gao

Journal: Exp Ther Med

PubMed ID: 34849158

Doi: 10.3892/etm.2021.10965

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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

Authors: Yusuf I Ertuna, Benedict Fallet, Anna-Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D Pinschewer

Journal: Cell Rep

PubMed ID: 34852228

Doi: 10.1016/j.celrep.2021.110061

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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells

Authors: Opeyemi S Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M Chew, Cecilia Shikuma, Costin Tomescu, Ashley F George, Nadia R Roan, Lishomwa C Ndhlovu, Qin Liu, Kar Muthumani, David B Weiner, Michael R Betts, Han Xiao, Mohamed Abdel-Mohsen

Journal: PLoS Pathog

PubMed ID: 34762717

Doi: 10.1371/journal.ppat.1010034

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Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation

Authors: Qisheng Zuo, Jin Jing, Jing Zhou, Yani Zhang, Wanhong Wei, Guohong Chen, Bichun Li

Journal: EMBO Rep

PubMed ID: 34747116

Doi: 10.15252/embr.202152491

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Genome-Wide Identification, Characterization and Expression Analysis of Soybean Gene Family

Authors: Bowei Jia, Yan Wang, Dajian Zhang, Wanhong Li, Hongli Cui, Jun Jin, Xiaoxi Cai, Yang Shen, Shengyang Wu, Yongxia Guo, Mingzhe Sun, Xiaoli Sun

Journal: Int J Mol Sci

PubMed ID: 34830077

Doi: 10.3390/ijms222212192

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Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments

Authors: Stephen J Winter, Hunter A Miller, Jill M Steinbach-Rankins

Journal: Pharmaceutics

PubMed ID: 34834307

Doi: 10.3390/pharmaceutics13111891

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Understanding the Role of Genus in the Digestion of Lignocellulose and Other Substrates in Vietnamese Native Goats' Rumen by Metagenomic Deep Sequencing

Authors: Trong-Khoa Dao, Thi-Huyen Do, Ngoc-Giang Le, Hong-Duong Nguyen, Thi-Quy Nguyen, Thi-Thu-Hong Le, Nam-Hai Truong

Journal: Animals (Basel)

PubMed ID: 34827987

Doi: 10.3390/ani11113257

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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Authors: Daniel Franjic, Mario Skarica, Shaojie Ma, Jon I Arellano, Andrew T N Tebbenkamp, Jinmyung Choi, Chuan Xu, Qian Li, Yury M Morozov, David Andrijevic, Zvonimir Vrselja, Ana Spajic, Gabriel Santpere, Mingfeng Li, Shupei Zhang, Yang Liu, Joshua Spurrier, Le Zhang, Ivan Gudelj, Lucija Rapan, Hideyuki Takahashi, Anita Huttner, Rong Fan, Stephen M Strittmatter, Andre M M Sousa, Pasko Rakic, Nenad Sestan

Journal: Neuron

PubMed ID: 34798047

Doi: 10.1016/j.neuron.2021.10.036

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Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

Authors: Hongyu Qiu, Xin-Yong Yuan, Teresa Cabral, Kathy Manguiat, Alyssia Robinson, Heidi Wood, Chris Grant, Peter McQueen, Garrett Westmacott, Daniel R Beniac, Lisa Lin, Michael Carpenter, Darwyn Kobasa, Tom Gräfenhan

Journal: Antiviral Res

PubMed ID: 34762975

Doi: 10.1016/j.antiviral.2021.105206

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ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

Authors: Natalya Pashkova, Lokesh Gakhar, Liping Yu, Nicholas J Schnicker, Annabel Y Minard, Stanley Winistorfer, Ivan E Johnson, Robert C Piper

Journal: Elife

PubMed ID: 34821552

Doi: 10.7554/eLife.72583

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Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2

Authors: Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, Ping Zhang, Xujun Xuan, Peiyi Wang, Zhiqiang Liu, Boda Zhou, Maojun Yang