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High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1

Authors: Xiaoli Tang, Xiaogang Ye, Xiaoxiao Wang, Shuo Zhao, Meiyu Wu, Jinghua Ruan, Boxiong Zhong

Journal: Sci Rep

PubMed ID: 34697320

Doi: 10.1038/s41598-021-00029-8

Products & Services: Gene Synthesis

Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors

Authors: Michalis Liontos, Evangelos Terpos, Christos Markellos, Flora Zagouri, Alexandros Briasoulis, Ioanna Katsiana, Efthymia Skafida, Oraianthi Fiste, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34696256

Doi: 10.3390/vaccines9101148

Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis

Authors: Annalisa Pianta, Geena Chiumento, Kristina Ramsden, Qi Wang, Klemen Strle, Sheila Arvikar, Catherine E Costello, Allen C Steere

Journal: Arthritis Rheumatol

PubMed ID: 34042327

Doi: 10.1002/art.41807

Products & Services: Bacterial Expression

Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

Products & Services: Custom DNA/RNA Oligos

Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology

Authors: Xiaoyu Du, Yuqin Wang, Shanyu Zhang, Pingping Fan, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Anal Chem

PubMed ID: 34641671

Doi: 10.1021/acs.analchem.1c02775

Products & Services: Plasmid DNA Preparation

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Authors: Shalom D Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin

Journal: Pharmaceutics

PubMed ID: 34683962

Doi: 10.3390/pharmaceutics13101669

Products & Services: Catalog Peptides

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Authors: Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki

Journal: J Exp Med

PubMed ID: 34647971

Doi: 10.1084/jem.20211327

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Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Authors: Harriet P Lo, Ye-Wheen Lim, Zherui Xiong, Nick Martel, Charles Ferguson, Nicholas Ariotti, Jean Giacomotto, James Rae, Matthias Floetenmeyer, Shayli Varasteh Moradi, Ya Gao, Vikas A Tillu, Di Xia, Huang Wang, Samira Rahnama, Susan J Nixon, Michele Bastiani, Ryan D Day, Kelly A Smith, Nathan J Palpant, Wayne A Johnston, Kirill Alexandrov, Brett M Collins, Thomas E Hall, Robert G Parton

Journal: J Cell Biol

PubMed ID: 34633413

Doi: 10.1083/jcb.201905065

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Profiling sirtuin activity using Copper-free click chemistry

Authors: Alyson M Curry, Ian Cohen, Song Zheng, Jessica Wohlfahrt, Dawanna S White, Dickson Donu, Yana Cen

Journal: Bioorg Chem

PubMed ID: 34655842

Doi: 10.1016/j.bioorg.2021.105413

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T cells promote metastasis by regulating extracellular matrix remodeling following chemotherapy

Authors: Jozafina Haj-Shomaly, Avital Vorontsova, Tamar Barenholz-Cohen, Oshrat Levi-Galibov, Mahesh Devarasetty, Michael Timaner, Ziv Raviv, Tim J Cooper, Shay Soker, Peleg Hasson, Daphne Weihs, Ruth Scherz-Shouval, Yuval Shaked

Journal: Cancer Res

PubMed ID: 34666995

Doi: 10.1158/0008-5472.CAN-21-1012

Products & Services: Catalog Antibody

Label-Free Colorimetric Method for Detection of by Trimming the G-Quadruplex DNAzyme with CRISPR/Cas12a

Authors: Xueyun Chen, Liu Wang, Fang He, Ganghui Chen, Linlin Bai, Kaiyu He, Fang Zhang, Xiahong Xu

Journal: Anal Chem

PubMed ID: 34645259

Doi: 10.1021/acs.analchem.1c03468

Products & Services: Bacterial Expression

Exosome-mediated delivery of inflammation-responsive mRNA for controlled atherosclerosis treatment

Authors: Te Bu, Zhelong Li, Ying Hou, Wenqi Sun, Rongxin Zhang, Lianbi Zhao, Mengying Wei, Guodong Yang, Lijun Yuan

Journal: Theranostics

PubMed ID: 34815799

Doi: 10.7150/thno.64229

Products & Services: Gene Synthesis

21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by HLA-A2 and HLA-C7 Molecules

Authors: Alexander Hellesen, Sigrid Aslaksen, Lars Breivik, Ellen Christine Røyrvik, Øyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne Bøe Wolff, Eystein Sverre Husebye, Eirik Bratland

Journal: Front Immunol

PubMed ID: 34721410

Doi: 10.3389/fimmu.2021.742848

Products & Services: Peptide Synthesis

A comparative study of mesenchymal stem cells cultured as cell-only aggregates and in encapsulated hydrogels

Authors: Fiona R Passanha, David B Gomes, Justyna Piotrowska, Lorenzo Moroni, Matthew B Baker, Vanessa L S LaPointe

Journal: J Tissue Eng Regen Med

PubMed ID: 34655456

Doi: 10.1002/term.3257

Products & Services: Peptide Synthesis

Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR

Authors: Christopher Szeto, Andrea T Nguyen, Christian A Lobos, Demetra S M Chatzileontiadou, Dhilshan Jayasinghe, Emma J Grant, Alan Riboldi-Tunnicliffe, Corey Smith, Stephanie Gras

Journal: Cells

PubMed ID: 34685626

Doi: 10.3390/cells10102646

Products & Services: Stable Cell Lines

Evaluation of the correlation between the access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test

Authors: Yutaro Kitagawa, Kazuo Imai, Masaru Matsuoka, Ai Fukada, Katsumi Kubota, Momoko Sato, Tomohito Takada, Sakiko Noguchi, Norihito Tarumoto, Shigefumi Maesaki, Shinichi Takeuchi, Takuya Maeda

Journal: J Med Virol

PubMed ID: 34524695

Doi: 10.1002/jmv.27338

Products & Services: Serology SARS-Cov-2 detection kits

AuNPs- Aβ-Ni-HRP sandwich assay: A new sensitive colorimetric method for the detection of Aβ

Authors: Zeeshan A Khan, Seungkyung Park

Journal: Talanta

PubMed ID: 34736673

Doi: 10.1016/j.talanta.2021.122946

Products & Services: Recombinant Proteins

TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps Interaction With SYK in Experimental Subarachnoid Hemorrhage

Authors: Xinyan Wu, Hanhai Zeng, Chaoran Xu, Huaijun Chen, Linfeng Fan, Hang Zhou, Qian Yu, Xiongjie Fu, Yucong Peng, Feng Yan, Xiaobo Yu, Gao Chen

Journal: Front Immunol

PubMed ID: 34721438

Doi: 10.3389/fimmu.2021.766178

Products & Services: Recombinant Antibody Expression

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Authors: Xianglei Liu, Doncho Zhelev, Cynthia Adams, Chuan Chen, John W Mellors, Dimiter S Dimitrov

Journal: Transl Oncol

PubMed ID: 34601396

Doi: 10.1016/j.tranon.2021.101232

Products & Services: Proteins, Expression, Isolation and Analysis

Xeno-Nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Authors: Irani Alves Ferreira-Bravo, Jeffrey J DeStefano

Journal: Viruses

PubMed ID: 34696413

Doi: 10.3390/v13101983

Products & Services: Proteins, Expression, Isolation and Analysis

Low-Field NMR Analysis of Chicken Patties Prepared with Woody Breast Meat and Implications to Meat Quality

Authors: Xiao Sun, Jinjie You, Yan Dong, Ligen Xu, Clay J Maynard, Casey M Owens

Journal: Foods

PubMed ID: 34681548

Doi: 10.3390/foods10102499

Products & Services: Proteins, Expression, Isolation and Analysis

Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations

Authors: Rafat Zrieq, Iqrar Ahmad, Mejdi Snoussi, Emira Noumi, Marcello Iriti, Fahad D Algahtani, Harun Patel, Mohd Saeed, Munazzah Tasleem, Shadi Sulaiman, Kaïss Aouadi, Adel Kadri

Journal: Int J Mol Sci

PubMed ID: 34639036

Doi: 10.3390/ijms221910693

Products & Services: Proteins, Expression, Isolation and Analysis

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

Authors: Holly Fowle, Ziran Zhao, Qifang Xu, Jason S Wasserman, Xinru Wang, Mary Adeyemi, Felicity Feiser, Alison N Kurimchak, Diba Atar, Brennan C McEwan, Arminja N Kettenbach, Rebecca Page, Wolfgang Peti, Roland L Dunbrack, Xavier Graña

Journal: Elife

PubMed ID: 34661528

Doi: 10.7554/eLife.63181

Products & Services: Proteins, Expression, Isolation and Analysis

miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis

Authors: Diego López-Márquez, Ángel Del-Espino, Nieves López-Pagán, Edgar A Rodríguez-Negrete, Ignacio Rubio-Somoza, Javier Ruiz-Albert, Eduardo R Bejarano, Carmen R Beuzón

Journal: J Exp Bot

PubMed ID: 34329403

Doi: 10.1093/jxb/erab354

Products & Services: Proteins, Expression, Isolation and Analysis

Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells

Authors: Kosuke Yokobori, Yuki Kawasaki, Yoshitaka Sekine, Sumihito Nobusawa, Toshiyuki Sakaki, Masahiko Negishi, Satoru Kakizaki

Journal: Biochem Pharmacol

PubMed ID: 34715066

Doi: 10.1016/j.bcp.2021.114794

Products & Services: Plasmid DNA Preparation

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Authors: Brion W Murray, Evan Rogers, Dayong Zhai, Wei Deng, Xi Chen, Paul A Sprengeler, Xin Zhang, Armin Graber, Siegfried H Reich, Shanna Stopatschinskaja, Benjamin Solomon, Benjamin Besse, Alexander Drilon

Journal: Mol Cancer Ther

PubMed ID: 34625502

Doi: 10.1158/1535-7163.MCT-21-0632

Products & Services: Plasmid DNA Preparation

MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling

Authors: Jianping Cao, Meng Jiang, Huafeng Ren, Kai Xu

Journal: Mol Med Rep

PubMed ID: 34676879

Doi: 10.3892/mmr.2021.12505

Products & Services: Plasmid DNA Preparation

KDM5B protein expressed in viable and fertile ΔARID mice exhibit no demethylase activity

Authors: Shirin Jamshidi, Steven Catchpole, Jie Chen, Chi Wai Eric So, Joy Burchell, Khondaker Miraz Rahman, Joyce Taylor-Papadimitriou

Journal: Int J Oncol

PubMed ID: 34713299

Doi: 10.3892/ijo.2021.5276

Products & Services: Plasmid DNA Preparation

Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability

Authors: Simona Graziano, Nuria Coll-Bonfill, Barbara Teodoro-Castro, Sahiti Kuppa, Jessica Jackson, Elena Shashkova, Urvashi Mahajan, Alessandro Vindigni, Edwin Antony, Susana Gonzalo

Journal: J Biol Chem

PubMed ID: 34648766

Doi: 10.1016/j.jbc.2021.101301

Products & Services: Plasmid DNA Preparation

Influence of Primary Structure on Fragmentation of Native-Like Proteins by Ultraviolet Photodissociation

Authors: Luis A Macias, Sarah N Sipe, Inês C Santos, Aarti Bashyal, M Rachel Mehaffey, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 34714071

Doi: 10.1021/jasms.1c00269

Products & Services: Peptide Synthesis

Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy

Authors: Feng Xie, Peng Su, Ting Pan, Xiaoxue Zhou, Heyu Li, Huizhe Huang, Aijun Wang, Fangwei Wang, Jun Huang, Haiyan Yan, Linghui Zeng, Long Zhang, Fangfang Zhou

Journal: Adv Mater

PubMed ID: 34665481

Doi: 10.1002/adma.202103471

Products & Services: Serology SARS-Cov-2 detection kits

A BioBricks toolbox for metabolic engineering of the tetracenomycin pathway

Authors: Jennifer T Nguyen, Kennedy K Riebschleger, Katelyn V Brown, Nina M Gorgijevska, S Eric Nybo

Journal: Biotechnol J.

PubMed ID: 34719127

Doi: doi.org/10.1002/biot.202100371

Products & Services: Gene Synthesis

Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns

Authors: Stefan Hümmer, Sonia Borao, Angel Guerra-Moreno, Luca Cozzuto, Elena Hidalgo, José Ayté

Journal: Cell Rep

PubMed ID: 34706246

Doi: 10.1016/j.celrep.2021.109893

Products & Services: PCR Cloning and Subcloning

The expression, localisation and interactome of pigeon CRY2

Authors: Spencer D Balay, Tobias Hochstoeger, Alexandra Vilceanu, E Pascal Malkemper, William Snider, Gerhard Dürnberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C Nordmann, Lyubov Ushakova, Simon Nimpf, David A Keays

Journal: Sci Rep

PubMed ID: 34645873

Doi: 10.1038/s41598-021-99207-x

Products & Services: PCR Cloning and Subcloning

Newcastle Disease Virus Vectored Chicken Infectious Anaemia Vaccine Induces Robust Immune Response in Chickens

Authors: Madhan Mohan Chellappa, Sohini Dey, Dinesh Chandra Pathak, Asmita Singh, Narayan Ramamurthy, Saravanan Ramakrishnan, Asok Kumar Mariappan, Kuldeep Dhama, Vikram N Vakharia

Journal: Viruses

PubMed ID: 34696415

Doi: 10.3390/v13101985

Products & Services: ORF cDNA Clones/MolecularCloud

Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Authors: Andreas Greinacher, Kathleen Selleng, Julia Mayerle, Raghavendra Palankar, Jan Wesche, Sven Reiche, Andrea Aebischer, Theodore E Warkentin, Maximilian Muenchhoff, Johannes C Hellmuth, Oliver T Keppler, Daniel Duerschmied, Achim Lother, Siegbert Rieg, Meinrad Paul Gawaz, Karin Anne Lydia Mueller, Christian S Scheer, Matthias Napp, Klaus Hahnenkamp, Guglielmo Lucchese, Antje Vogelgesang, Agnes Flöel, Piero Lovreglio, Angela Stufano, Rolf Marschalek, Thomas Thiele

Journal: Blood

PubMed ID: 34280256

Doi: 10.1182/blood.2021012938

Products & Services: Mutant Libraries

The Sigma-1 receptor is an ER-localized type II membrane protein

Authors: Neeraj Sharma, Chaitanya Patel, Marina Shenkman, Amit Kessel, Nir Ben-Tal, Gerardo Z Lederkremer

Journal: J Biol Chem

PubMed ID: 34648767

Doi: 10.1016/j.jbc.2021.101299

Products & Services: Monoclonal Antibody Services

Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure

Authors: Wai Shun Mak, Tsz Ming Tsang, Tsz Yin Chan, Georgi L Lukov

Journal: Proteomes

PubMed ID: 34698247

Doi: 10.3390/proteomes9040040

Products & Services: DNA Sequencing

A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells

Authors: Thomas Welte, Junhua Mai, Zhe Zhang, Shaohui Tian, Guodong Zhang, Yitian Xu, Licheng Zhang, Shu-Shia Chen, Tian Wang, Haifa Shen

Journal: iScience

PubMed ID: 34825135

Doi: 10.1016/j.isci.2021.103349

Products & Services: DNA Sequencing

Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom

Authors: Sherin Kaul, L Sai Keerthana, Pankaj Kumar, Komal Birader, Yathirajarao Tammineni, Deepali Rawat, Pankaj Suman

Journal: PLoS Negl Trop Dis

PubMed ID: 34634067

Doi: 10.1371/journal.pntd.0009841

Products & Services: DNA Sequencing

The periplasmic expression and purification of AA15 lytic polysaccharide monooxygenases from insect species in Escherichia coli

Authors: João Paulo L Franco Cairo, Dnane V Almeida, André Damasio, Wanius Garcia, Fabio M Squina

Journal: Protein Expr Purif

PubMed ID: 34655732

Doi: 10.1016/j.pep.2021.105994

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Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in and

Authors: Haley S Ball, Misgina B Girma, Mosufa Zainab, Iswarduth Soojhawon, Robin D Couch, Schroeder M Noble

Journal: ACS Infect Dis

PubMed ID: 34672535

Doi: 10.1021/acsinfecdis.1c00132

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Bacterial Quorum-Quenching Lactonase Hydrolyzes Fungal Mycotoxin and Reduces Pathogenicity of -Suggesting a Mechanism of Bacterial Antagonism

Authors: Shlomit Dor, Dov Prusky, Livnat Afriat-Jurnou

Journal: J Fungi (Basel)

PubMed ID: 34682247

Doi: 10.3390/jof7100826

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Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins

Authors: Tomomi Shionoya, Manish Singh, Misao Mizuno, Hideki Kandori, Yasuhisa Mizutani

Journal: Biochemistry

PubMed ID: 34601881

Doi: 10.1021/acs.biochem.1c00529

Products & Services: Codon Optimization

A Thermostable Cas12b from Leverages One-pot Detection of SARS-CoV-2 Variants of Concern

Authors: Long T Nguyen, Nicolas C Macaluso, Brianna L M Pizzano, Melanie N Cash, Jan Spacek, Jan Karasek, Rhoel R Dinglasan, Marco Salemi, Piyush K Jain

Journal: medrxiv

PubMed ID: 34704101

Doi: 10.1101/2021.10.15.21265066

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Homocysteine Inhibits Pro-Insulin Receptor Cleavage and Causes Insulin Resistance Via Protein Cysteine-Homocysteinylation

Authors: Xuan Zhang, Yuan-Yuan Qu, Lian Liu, Ya-Nan Qiao, Hao-Ran Geng, Yan Lin, Wei Xu, Jing Cao, Jian-Yuan Zhao

Journal: Cell Rep

PubMed ID: 34644569

Doi: 10.2139/ssrn.3830772

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Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang

Journal: Viruses

PubMed ID: 34834981

Doi: 10.3390/v13112175

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Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis

Authors: Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim

Journal: Front Immunol

PubMed ID: 34691014

Doi: 10.3389/fimmu.2021.646316

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The S Protein of Group B Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome

Authors: Anaamika Campeau, Satoshi Uchiyama, Concepcion Sanchez, Consuelo Sauceda, Victor Nizet, David J Gonzalez

Journal: Front Microbiol

PubMed ID: 34721327

Doi: 10.3389/fmicb.2021.729308

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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

Authors: Keren Isaev, Lingyan Jiang, Shuai Wu, Christian A Lee, Valérie Watters, Victoire Fort, Ricky Tsai, Fiona J Coutinho, Samer M I Hussein, Jie Zhang, Jinsong Wu, Peter B Dirks, Daniel Schramek, Jüri Reimand

Journal: Cell Rep

PubMed ID: 34686327

Doi: 10.1016/j.celrep.2021.109873

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MYB70 modulates seed germination and root system development in

Authors: Jinpeng Wan, Ruling Wang, Ping Zhang, Liangliang Sun, Qiong Ju, Haodong Huang, Shiyou Lü, Lam-Son Tran, Jin Xu

Journal: iScience

PubMed ID: 34746697

Doi: 10.1016/j.isci.2021.103228

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Function Analysis of Resistance to Bamlanivimab by SARS-CoV-2 Variants Kappa, Delta, and Lambda

Authors: Shufeng Liu, Tien Huynh, Charles B Stauft, Tony T Wang, Binquan Luan

Journal: J Chem Inf Model

PubMed ID: 34648284

Doi: 10.1021/acs.jcim.1c01058

Products & Services: Recombinant Proteins

Effect of Cotton Leafroll Dwarf Virus on Physiological Processes and Yield of Individual Cotton Plants

Authors: Ved Parkash, Divya Bhanu Sharma, John Snider, Sudeep Bag, Phillip Roberts, Afsha Tabassum, Dalton West, Sameer Khanal, Nelson Suassuna, Peng Chee

Journal: Front Plant Sci

PubMed ID: 34659302

Doi: 10.3389/fpls.2021.734386

Products & Services: PCR and Cloning

NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Authors: Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J Ulevitch, Jiahuai Han

Journal: Sci Adv

PubMed ID: 34678072

Doi: 10.1126/sciadv.abi9471

Products & Services: PCR and Cloning

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Authors: Martijn A Langereis, Irina C Albulescu, Judith Stammen-Vogelzangs, Morindy Lambregts, Ken Stachura, Suzan Miller, Angela M Bosco-Lauth, Airn E Hartwig, Stephanie M Porter, Michelle Allen, Mark Mogler, Frank J M van Kuppeveld, Berend-Jan Bosch, Paul Vermeij, Ad de Groof, Richard A Bowen, Randy Davis, Zach Xu, Ian Tarpey

Journal: npj Vaccines

PubMed ID: 34671047

Doi: 10.1038/s41541-021-00390-9

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Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Authors: Marumi Ohno, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md Abdul Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida, Hirofumi Sawa, Masashi Shingai

Journal: Viruses

PubMed ID: 34834944

Doi: 10.3390/v13112137

Products & Services: Codon Optimization

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

Authors: Kevin J Forsberg, Danica T Schmidtke, Rachel Werther, Ruben V Uribe, Deanna Hausman, Morten O A Sommer, Barry L Stoddard, Brett K Kaiser, Harmit S Malik

Journal: PLoS Biol

PubMed ID: 34644300

Doi: 10.1371/journal.pbio.3001428

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Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation

Authors: Krishna K Sarangapani, Lori B Koch, Christian R Nelson, Charles L Asbury, Sue Biggins

Journal: J Cell Biol

PubMed ID: 34647959

Doi: 10.1083/jcb.202106130

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Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

Authors: Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Journal: iScience

PubMed ID: 34825148

Doi: 10.1016/j.isci.2021.103396

Products & Services: Gene Synthesis

Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia

Authors: Nithya Balasundaram, Saravanan Ganesan, Ezhilarasi Chendamarai, Hamenth Kumar Palani, Arvind Venkatraman, Ansu Abu Alex, Sachin David, Swathy Palanikumar, Nair Reeshma Radhakrishnan, Mohammed Yasar M, Sanjeev Krishna, Anu Korula, Uday Kulkarni, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Vikram Mathews

Journal: Blood Adv

PubMed ID: 34625794

Doi: 10.1182/bloodadvances.2021005300

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Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

Authors: Katelyn Mika, Mirna Marinić, Manvendra Singh, Joanne Muter, Jan Joris Brosens, Vincent J Lynch

Journal: Elife

PubMed ID: 34623259

Doi: 10.7554/eLife.69584

Products & Services: Plasmid DNA Preparation

Design of a synthesis-friendly hypoxia-responsive promoter for cell-based therapeutics

Authors: Chee Ka Candice Lam, Kevin Truong

Journal: Eng Life Sci

PubMed ID: 34899121

Doi: 10.1002/elsc.202100045

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Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost

Authors: Tamara Davidovic, Judith Schimpf, Armin Abbassi-Nik, Richard Stockinger, Hannelore Sprenger-Mähr, Karl Lhotta, Emanuel Zitt

Journal: Kidney Int

PubMed ID: 34656642

Doi: 10.1016/j.kint.2021.10.006

Epitopes prediction for microcystin-LR by molecular docking

Authors: Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34717216

Doi: 10.1016/j.ecoenv.2021.112925

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Quantifying oxidation of cellulose-associated glucuronoxylan by two lytic polysaccharide monooxygenases from

Authors: Olav A Hegnar, Heidi Østby, Dejan M Petrović, Lisbeth Olsson, Anikó Várnai, Vincent G H Eijsink

Journal: Appl Environ Microbiol

PubMed ID: 34613755

Doi: 10.1128/AEM.01652-21

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Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Authors: Naiyan Lu, Xinhe Wang, Wentao Shi, Lu Bian, Xuan Zhang, Guofeng Yang, Xue Tang, Jun Wang, Yin Zou, Yuyan Weng

Journal: Nanoscale Res Lett

PubMed ID: 34637014

Doi: 10.1186/s11671-021-03610-2

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In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain

Authors: Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Linnea Molander, Johannes Fuchs, Ruth H Palmer

Journal: J Mol Biol

PubMed ID: 34624297

Doi: 10.1016/j.jmb.2021.167282

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CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Authors: Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu

Journal: Theranostics

PubMed ID: 34815788

Doi: 10.7150/thno.62187

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Combining an optimized mRNA template with a double purification process allows strong expression of transcribed mRNA

Authors: Sergio Linares-Fernández, Julien Moreno, Elise Lambert, Perrine Mercier-Gouy, Laetitia Vachez, Bernard Verrier, Jean-Yves Exposito

Journal: Mol Ther Nucleic Acids

PubMed ID: 34692232

Doi: 10.1016/j.omtn.2021.10.007

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Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

Authors: Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu

Journal: Front Cell Dev Biol

PubMed ID: 34778244

Doi: 10.3389/fcell.2021.666025

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Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Authors: Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann

Journal: Elife

PubMed ID: 34713805

Doi: 10.7554/eLife.69832

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Aptamer-modified biosensors to visualize neurotransmitter flux

Authors: Charlotte Moraldo, Emilie Vuille-Dit-Bille, Bajramshahe Shkodra, Tom Kloter, Nako Nakatsuka

Journal: J Neurosci Methods

PubMed ID: 34653500

Doi: 10.1016/j.jneumeth.2021.109386

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Anastrozole regulates fatty acid synthase in breast cancer

Authors: Junmei Cairns, James N Ingle, Krishna R Kalari, Matthew P Goetz, Richard M Weinshilboum, Huanyao Gao, Hu Li, Mehrab Ghanat Bari, Liewei Wang

Journal: Mol Cancer Ther

PubMed ID: 34667110

Doi: 10.1158/1535-7163.MCT-21-0509

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Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Authors: Young-Jun Park, Anna De Marco, Tyler N Starr, Zhuoming Liu, Dora Pinto, Alexandra C Walls, Fabrizia Zatta, Samantha K Zepeda, John Bowen, Kaitlin S Sprouse, Anshu Joshi, Martina Giurdanella, Barbara Guarino, Julia Noack, Rana Abdelnabi, Shi-Yan Caroline Foo, Florian A Lempp, Fabio Benigni, Gyorgy Snell, Johan Neyts, Sean Pj Whelan, Herbert W Virgin, Jesse D Bloom, Davide Corti, Matteo Samuele Pizzuto, David Veesler

Journal: biorxiv

PubMed ID: 34671770

Doi: 10.1101/2021.10.13.464254

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Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

Authors: Sanket S Ponia, Shelly J Robertson, Kristin L McNally, Gayatri Subramanian, Gail L Sturdevant, Matthew Lewis, Forrest Jessop, Catherine Kendall, Dylan Gallegos, Arielle Hay, Cindi Schwartz, Rebecca Rosenke, Greg Saturday, Catherine M Bosio, Craig Martens, Sonja M Best

Journal: Cell Rep

PubMed ID: 34706234

Doi: 10.1016/j.celrep.2021.109888

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ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Authors: Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L Pierri, Anna De Grassi, Niamh C Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A J O'Neill, Vittoria Infantino

Journal: Cells

PubMed ID: 34831186

Doi: 10.3390/cells10112962

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Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Authors: Frank Kozielski, Céleste Sele, Vladimir O Talibov, Jiaqi Lou, Danni Dong, Qian Wang, Xinyue Shi, Maria Nyblom, Annika Rogstam, Tobias Krojer, Zoë Fisher, Wolfgang Knecht

Journal: RSC Chem Biol

PubMed ID: 35128408

Doi: 10.1039/d1cb00135c

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Effects of Distal Mutations on Ligand-Binding Affinity in Dihydrofolate Reductase

Authors: Chen-Hua Huang, Yun-Wen Chen, Tsun-Tsao Huang, Ya-Ting Kao

Journal: ACS Omega

PubMed ID: 34660967

Doi: 10.1021/acsomega.1c02995

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Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Authors: Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Journal: Front Immunol

PubMed ID: 34745083

Doi: 10.3389/fimmu.2021.670338

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Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 2647 macrophages

Authors: Shan Hong, Vermont P Dia, Qixin Zhong

Journal: Int J Biol Macromol

PubMed ID: 34717976

Doi: 10.1016/j.ijbiomac.2021.10.153

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Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome

Authors: Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang

Journal: FASEB J

PubMed ID: 34516679

Doi: 10.1096/fj.202101030R

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JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance

Authors: Dongjoo You, Byung Chul Jung, Sneha Damal Villivalam, Hee-Woong Lim, Sona Kang

Journal: Diabetes

PubMed ID: 34686520

Doi: 10.2337/db21-0596

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Nep1‐like Proteins from Valsa mali Differentially Regulate Pathogen Virulence and Response to Abiotic Stresses

Authors: Jianying Liu, Jiajun Nie, Yali Chang, Lili Huang

Journal: Journal of Fungi

Doi: 10.3390/jof7100830

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Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Authors: Chenxi Li, Yanyang Zhou, Xuan Chen, Yanbing Zhang, Jingbo Hu, Cicheng Ren, Jingjing Ding, Daoyuan Jiang, Yanhua Li

Journal: Dev Comp Immunol

PubMed ID: 34626690

Doi: 10.1016/j.dci.2021.104290

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USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates

Authors: Thang Van Nguyen

Journal: Proc Natl Acad Sci USA

PubMed ID: 34583995

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Roles of Small Subunits of Laccase (ssPOXA3a/b) in Laccase Production by Pleurotus eryngii var. ferulae

Authors: Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding

Journal: J Agric Food Chem.

PubMed ID: 34696587

Doi: doi.org/10.1021/acs.jafc.1c04777

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Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

Authors: Isabel Pablos, Yoan Machado, Hugo C Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A Bell, Georgina S Butler, Peter M Grin, Quynh T Cao, Jenny P Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N Kizhakkedathu, Karen Mossman, Jeremy A Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M Overall

Journal: Cell Rep

PubMed ID: 34672947

Doi: 10.1016/j.celrep.2021.109892

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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors: Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong

Journal: Signal Transduct Target Ther

PubMed ID: 34645784

Doi: 10.1038/s41392-021-00777-z

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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Authors: Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang , Xu Li

Journal: Dev Cell

PubMed ID: 34626540

Doi: 10.1016/j.devcel.2021.09.015

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CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense

Authors: Xue-Peng Li, Guan-Yu Chen, Qiu Jin, Fang-Rui Lou, Bing-Jian Liu, Jian Zhang, Ji-Xing Feng, Tian-Tian Chen

Journal: Int J Biol Macromol

PubMed ID: 34666131

Doi: 10.1016/j.ijbiomac.2021.10.080

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Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Authors: Yan Li, Siyu Shen, Haoran Guo, Zhe Zhang, Lili Zhang, Qingran Yang, Yanhang Gao, Junqi Niu, Wei Wei

Journal: Front Microbiol

PubMed ID: 34733242

Doi: 10.3389/fmicb.2021.706241

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Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Authors: Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34628068

Doi: 10.1016/j.parint.2021.102479

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The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3 Against With No Detectable Resistance

Authors: Depeng Zhu, Fangyi Chen, Yan-Chao Chen, Hui Peng, Ke-Jian Wang

Journal: Front Cell Infect Microbiol

PubMed ID: 34676176

Doi: 10.3389/fcimb.2021.752637

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Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana

Authors: Tong Zhu, Xue Zhou, Jian-Long Zhang, Wei-Hao Zhang, Li-Pei Zhang, Chun-Xiang You, Paula E Jameson, Peng-Tao Ma, Shan-Li Guo

Journal: Mol Plant Pathol

PubMed ID: 34633738

Doi: 10.1111/mpp.13139

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NORHA, a novel follicular atresia-related lncRNA, promotes porcine granulosa cell apoptosis via the miR-183-96-182 cluster and FoxO1 axis

Authors: Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li

Journal: J Anim Sci Biotechnol

PubMed ID: 34615552

Doi: 10.1186/s40104-021-00626-7

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Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Authors: Poorya Sadeghi, Hessamaddin Sohrabi, Maryam Hejazi, Ali Jahanban-Esfahlan, Behzad Baradaran, Maryam Tohidast, Mir Reza Majidi, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar, Miguel de la Guardia

Journal: Trends Analyt Chem

PubMed ID: 34697511

Doi: 10.1016/j.trac.2021.116460

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Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8 T cells

Authors: Margot Miranda-Katz, John J Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John V Williams

Journal: Sci Rep

PubMed ID: 34675220

Doi: 10.1038/s41598-021-00023-0

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Arabidopsis fibrillin 1-2 subfamily exerts their functions via specific protein-protein interactions

Authors: Diego Torres-Romero, Ángeles Gómez-Zambrano, Antonio Jesús Serrato, Mariam Sahrawy, Ángel Mérida