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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

Authors: Yusuf I Ertuna, Benedict Fallet, Anna-Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D Pinschewer

Journal: Cell Rep

PubMed ID: 34852228

Doi: 10.1016/j.celrep.2021.110061

Products & Services: Mutagenesis Services

Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells

Authors: Opeyemi S Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M Chew, Cecilia Shikuma, Costin Tomescu, Ashley F George, Nadia R Roan, Lishomwa C Ndhlovu, Qin Liu, Kar Muthumani, David B Weiner, Michael R Betts, Han Xiao, Mohamed Abdel-Mohsen

Journal: PLoS Pathog

PubMed ID: 34762717

Doi: 10.1371/journal.ppat.1010034

Products & Services: Plasmid DNA Preparation

Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation

Authors: Qisheng Zuo, Jin Jing, Jing Zhou, Yani Zhang, Wanhong Wei, Guohong Chen, Bichun Li

Journal: EMBO Rep

PubMed ID: 34747116

Doi: 10.15252/embr.202152491

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-Wide Identification, Characterization and Expression Analysis of Soybean Gene Family

Authors: Bowei Jia, Yan Wang, Dajian Zhang, Wanhong Li, Hongli Cui, Jun Jin, Xiaoxi Cai, Yang Shen, Shengyang Wu, Yongxia Guo, Mingzhe Sun, Xiaoli Sun

Journal: Int J Mol Sci

PubMed ID: 34830077

Doi: 10.3390/ijms222212192

Products & Services: Protein Tools

Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments

Authors: Stephen J Winter, Hunter A Miller, Jill M Steinbach-Rankins

Journal: Pharmaceutics

PubMed ID: 34834307

Doi: 10.3390/pharmaceutics13111891

Products & Services: Recombinant Proteins

Understanding the Role of Genus in the Digestion of Lignocellulose and Other Substrates in Vietnamese Native Goats' Rumen by Metagenomic Deep Sequencing

Authors: Trong-Khoa Dao, Thi-Huyen Do, Ngoc-Giang Le, Hong-Duong Nguyen, Thi-Quy Nguyen, Thi-Thu-Hong Le, Nam-Hai Truong

Journal: Animals (Basel)

PubMed ID: 34827987

Doi: 10.3390/ani11113257

Products & Services: Gene Synthesis

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Authors: Daniel Franjic, Mario Skarica, Shaojie Ma, Jon I Arellano, Andrew T N Tebbenkamp, Jinmyung Choi, Chuan Xu, Qian Li, Yury M Morozov, David Andrijevic, Zvonimir Vrselja, Ana Spajic, Gabriel Santpere, Mingfeng Li, Shupei Zhang, Yang Liu, Joshua Spurrier, Le Zhang, Ivan Gudelj, Lucija Rapan, Hideyuki Takahashi, Anita Huttner, Rong Fan, Stephen M Strittmatter, Andre M M Sousa, Pasko Rakic, Nenad Sestan

Journal: Neuron

PubMed ID: 34798047

Doi: 10.1016/j.neuron.2021.10.036

Products & Services: Recombinant Antibody Expression

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

Authors: Hongyu Qiu, Xin-Yong Yuan, Teresa Cabral, Kathy Manguiat, Alyssia Robinson, Heidi Wood, Chris Grant, Peter McQueen, Garrett Westmacott, Daniel R Beniac, Lisa Lin, Michael Carpenter, Darwyn Kobasa, Tom Gräfenhan

Journal: Antiviral Res

PubMed ID: 34762975

Doi: 10.1016/j.antiviral.2021.105206

Products & Services: Proteins, Expression, Isolation and Analysis

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

Authors: Natalya Pashkova, Lokesh Gakhar, Liping Yu, Nicholas J Schnicker, Annabel Y Minard, Stanley Winistorfer, Ivan E Johnson, Robert C Piper

Journal: Elife

PubMed ID: 34821552

Doi: 10.7554/eLife.72583

Products & Services: Monoclonal Antibody Services

Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2

Authors: Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, Ping Zhang, Xujun Xuan, Peiyi Wang, Zhiqiang Liu, Boda Zhou, Maojun Yang

Journal: Cell Discov

PubMed ID: 34728622

Doi: 10.1038/s41421-021-00334-6

Products & Services: Proteins, Expression, Isolation and Analysis

BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2

Authors: R Camille Brewer, Nitya S Ramadoss, Lauren J Lahey, Shaghayegh Jahanbani, William H Robinson, Tobias V Lanz

Journal: Nat Immunol

PubMed ID: 34848871

Doi: 10.1038/s41590-021-01088-9

Products & Services: Monoclonal Antibody Services

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Authors: Toshinori Ando, Nadia Arang, Zhiyong Wang, Daniela Elena Costea, Xiaodong Feng, Yusuke Goto, Hiroki Izumi, Mara Gilardi, Kazuyo Ando, J Silvio Gutkind

Journal: Commun Biol

PubMed ID: 34725466

Doi: 10.1038/s42003-021-02744-4

Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket

Authors: Dinesh M Fernando, Clifford T Gee, Elizabeth C Griffith, Christopher J Meyer, Laura A Wilt, Rajendra Tangallapally, Miranda J Wallace, Darcie J Miller, Richard E Lee

Journal: Tuberculosis (Edinb)

PubMed ID: 34894561

Doi: 10.1016/j.tube.2021.102157

Products & Services: Bacterial Expression

Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

Products & Services: Monoclonal Antibody Services

Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs

Authors: Anjali Y Bhagirath, Vikram Bhatia, Manoj Reddy Medapati, Nisha Singh, Martha Hinton, Prashen Chelikani, Shyamala Dakshinamurti

Journal: FASEB Bioadv

PubMed ID: 35664968

Doi: 10.1096/fba.2021-00073

Products & Services: Mammalian Expression

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD/SIRT6 axis

Authors: Christopher A Koczor, Kate M Saville, Joel F Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V Makarov, Marie E Migaud, Robert W Sobol

Journal: Cell Rep

PubMed ID: 34731617

Doi: 10.1016/j.celrep.2021.109917

Products & Services: DNA Sequencing

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

Authors: Hsiang-Chi Huang, Yun-Ju Lai, Chun-Che Liao, Wang-Feng Yang, Ke-Bin Huang, I-Jung Lee, Wen-Cheng Chou, Shih-Han Wang, Ling-Hui Wang, Jung-Mao Hsu, Cheng-Pu Sun, Chun-Tse Kuo, Jyun Wang, Tzu-Chun Hsiao, Po-Jiun Yang, Te-An Lee, Wilson Huang, Fu-An Li, Chen-Yang Shen, Yi-Ling Lin, Mi-Hua Tao, Chia-Wei Li

Journal: EBioMedicine

PubMed ID: 34839261

Doi: 10.1016/j.ebiom.2021.103712

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid Response to SARS-CoV-2 in Aotearoa New Zealand: Implementation of a Diagnostic Test and Characterization of the First COVID-19 Cases in the South Island

Authors: Blair Lawley, Jenny Grant, Rhodri Harfoot, Jackson M Treece, Robert Day, Leonor C Hernández, Jo-Ann L Stanton, James E Ussher, Miguel E Quiñones-Mateu

Journal: Viruses

PubMed ID: 34835031

Doi: 10.3390/v13112222

Products & Services: Plasmid DNA Preparation

MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Authors: Avelino C Verceles, Pavan Bhat, Zain Nagaria, Destiny Martin, Harsh Patel, Afua Ntem-Mensah, Sang W Hyun, Andrea Hahn, Jean Jeudy, Alan S Cross, Erik P Lillehoj, Simeon E Goldblum

Journal: Sci Rep

PubMed ID: 34811449

Doi: 10.1038/s41598-021-02242-x

Products & Services: Codon Optimization

An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

Authors: Dengning Xia, Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M Saad Bhamla, Chinglai Yang, Mark R Prausnitz

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34670842

Doi: 10.1073/pnas.2110817118

Products & Services: Plasmid DNA Preparation

Development and Characterization of Magnetic SARS-CoV-2 Peptide-Imprinted Polymers

Authors: Beatriz Fresco-Cala, Soumya Rajpal, Tamara Rudolf, Benedikt Keitel, Rüdiger Groß, Jan Münch, Alex D Batista, Boris Mizaikoff

Journal: Nanomaterials (Basel)

PubMed ID: 34835749

Doi: 10.3390/nano11112985

Products & Services: Catalog Peptides

Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival

Authors: Fiamma Berner, Rebekka Niederer, Jolien J Luimstra, Oltin Tiberiu Pop, Ann-Kristin Jochum, Mette-Triin Purde, Omar Hasan Ali, David Bomze, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marissa Lisa Dubbelaar, Marie-Therese Abdou, Petra Baumgaertner, Christina Appenzeller, Caroline Cicin-Sain, Tobias Lenz, Daniel E Speiser, Burkhard Ludewig, Christoph Driessen, Markus Jörger, Martin Früh, Wolfram Jochum, Antonio Cozzio, Hans-Georg Rammensee, Juliane Walz, Jacques Neefjes, Lukas Flatz

Journal: Oncoimmunology

PubMed ID: 34858733

Doi: 10.1080/2162402X.2021.2006893

Products & Services: Peptide Synthesis

Lipid-Binding Aegerolysin from Biocontrol Fungus

Authors: Nada Kraševec, Anastasija Panevska, Špela Lemež, Jaka Razinger, Kristina Sepčić, Gregor Anderluh, Marjetka Podobnik

Journal: Toxins (Basel)

PubMed ID: 34822604

Doi: 10.3390/toxins13110820

Products & Services: Bacterial Expression

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Authors: Elwood A Mullins, Jonathan Dorival, Gong-Li Tang, Dale L Boger, Brandt F Eichman

Journal: Nat Commun

PubMed ID: 34836957

Doi: 10.1038/s41467-021-27284-7

Products & Services: Custom Vector Construction

VviPLATZ1 is a major factor that controls female flower morphology determination in grapevine

Authors: Pat Iocco-Corena, Jamila Chaïb, Laurent Torregrosa, Don Mackenzie, Mark R Thomas, Harley M Smith

Journal: Nat Commun

PubMed ID: 34848714

Doi: 10.1038/s41467-021-27259-8

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells

Authors: Wenjia Peng, Shuai Li, Shiyue Chen, Jiacheng Yang, Ze Sun

Journal: Front Cardiovasc Med

PubMed ID: 34912856

Doi: 10.3389/fcvm.2021.731890

Products & Services: Custom DNA/RNA Oligos

Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

Products & Services: Plasmid DNA Preparation

Surrogate test performance for SARS-CoV-2 neutralizing antibodies (nAbs) for convalescent plasma (CCP): How useful could they be?

Authors: Silvano Wendel, Roberta Fachini, Rita C L Fontão-Wendel, Ralyria Mello, Carlos Vinícius Velasquez, Rafael Rahal Guaragna Machado, Mayra Altobelli Brito, Marcelo Amaral, Camila Pereira Soares, Ruth Achkar, Patrícia Scuracchio, Sandra Cristina Miyaji, Melina Santos Erdens, Edison Luiz Durigon

Journal: Transfusion

PubMed ID: 34674284

Doi: 10.1111/trf.16714

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Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: medrxiv

PubMed ID: 34729569

Doi: 10.1101/2021.10.27.21265561

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Comparing Five SARS-CoV-2 Antibody Assay Results Before and After the First and Second ChAdOx1 nCoV-19 Vaccination Among Health Care Workers: A Prospective Multicenter Study

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34613799

Doi: 10.1128/JCM.01788-21

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Authors: Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan

Journal: Sci Transl Med

PubMed ID: 34519517

Doi: 10.1126/scitranslmed.abj5413

Products & Services: Recombinant Antibody Expression

SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

Authors: Maoquan Li, Jinqiu Ning, Jiwei Wang, Qiqian Yan, Ke Zhao, Xiaoshi Jia

Journal: Int J Mol Med

PubMed ID: 34617577

Doi: 10.3892/ijmm.2021.5043

Products & Services: Proteins, Expression, Isolation and Analysis

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Authors: Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B Sanz-Martos, Francisco Zafra

Journal: Cell Mol Life Sci

PubMed ID: 34709416

Doi: 10.1007/s00018-021-03998-1

Products & Services: Proteins, Expression, Isolation and Analysis

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Authors: Guha Asthagiri Arunkumar, Disha Bhavsar, Tiehai Li, Shirin Strohmeier, Veronika Chromikova, Fatima Amanat, Mehman Bunyatov, Patrick C Wilson, Ali H Ellebedy, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Florian Krammer

Journal: Nat Commun

PubMed ID: 34697321

Doi: 10.1038/s41467-021-26409-2

Products & Services: Proteins, Expression, Isolation and Analysis

Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway

Authors: Xin Lin, Yong Zhu, Guohui Le

Journal: J Interferon Cytokine Res

PubMed ID: 34698528

Doi: 10.1089/jir.2021.0083

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of From the Marine Crab and Its Functions Under Low Salinity Conditions

Authors: Xianyun Ren, Lei Wang, Yao Xu, Qiong Wang, Jianjian Lv, Ping Liu, Jian Li

Journal: Front Physiol

PubMed ID: 34744765

Doi: 10.3389/fphys.2021.724693

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic Engineering of for Improved 2,3-Butanediol Production by Manipulating NADH Levels and Overexpressing the Small RNA RyhB

Authors: Yan Wu, Wanying Chu, Jiayao Yang, Yudong Xu, Qi Shen, Haoning Yang, Fangxu Xu, Yefei Liu, Ping Lu, Ke Jiang, Hongxin Zhao

Journal: Front Microbiol

PubMed ID: 34691005

Doi: 10.3389/fmicb.2021.754306

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The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice

Authors: Guendalina Zaccaria, Daniela Malatesta, Lucija Jurisic, Maurilia Marcacci, Giovanni Di Teodoro, Annamaria Conte, Liana Teodori, Federica Monaco, Valeria Marini, Claudia Casaccia, Giovanni Savini, Annapia Di Gennaro, Emanuela Rossi, Vincenzo D'Innocenzo, Nicola D'Alterio, Alessio Lorusso

Journal: Vet Microbiol

PubMed ID: 34715462

Doi: 10.1016/j.vetmic.2021.109262

Products & Services: Plasmid DNA Preparation

Novel Phage-Derived Depolymerase with Activity against Biofilms

Authors: Cormac J Rice, Stephen A Kelly, Seamus C O'Brien, Erinn M Melaugh, Jan C B Ganacias, Zheng Hua Chai, Brendan F Gilmore, Timofey Skvortsov

Journal: Microorganisms

PubMed ID: 34683494

Doi: 10.3390/microorganisms9102172

Products & Services: Plasmid DNA Preparation

Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection

Authors: Yin Liu, Yanling Chen, Shisheng Huang, Xiaodong Ma, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Frontiers

Doi: 10.3389/fmolb.2021.753276

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Regulate the hydrophobic motif to enhance the non-classical secretory expression of Pullulanase PulA in Bacillus subtilis

Authors: Jie Zhen, Hongchen Zheng, Xingya Zhao, Xiaoping Fu, Shibin Yang, Jianyong Xu, Hui Song, Yanhe Ma

Journal: Int J Biol Macromol

PubMed ID: 34710472

Doi: 10.1016/j.ijbiomac.2021.10.164

Products & Services: PCR Cloning and Subcloning

Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Authors: Kazuhiro Kobuke, Kenji Oki, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez, Kiyotaka Itcho, Haruya Ohno, Gaku Nagano, Yoko Yoshii, Ryuta Baba, Takaya Kodama, Koji Arihiro, Noboru Hattori, Masayasu Yoneda

Journal: Int J Mol Sci

PubMed ID: 34681640

Doi: 10.3390/ijms222010981

Products & Services: PCR Cloning and Subcloning

Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel

Authors: Ying Wang, Yi-Chi Zhang, Ke-Xin Zhang, Zhong-Qiang Jia, Tao Tang, Lin-Lin Zheng, Di Liu, Chun-Qing Zhao

Journal: Pest Manag Sci

PubMed ID: 34619015

Doi: 10.1002/ps.6669

Products & Services: PCR and Cloning

FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2

Authors: Jenna M DeLuca, Maegan K Murphy, Xin Wang, Timothy J Wilson

Journal: J Immunol

PubMed ID: 34697226

Doi: 10.4049/jimmunol.2100218

Products & Services: Mutagenesis Services

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Authors: Vincent Dussupt, Rajeshwer S Sankhala, Letzibeth Mendez-Rivera, Samantha M Townsley, Fabian Schmidt, Lindsay Wieczorek, Kerri G Lal, Gina C Donofrio, Ursula Tran, Nathaniel D Jackson, Weam I Zaky, Michelle Zemil, Sarah R Tritsch, Wei-Hung Chen, Elizabeth J Martinez, Aslaa Ahmed, Misook Choe, William C Chang, Agnes Hajduczki, Ningbo Jian, Caroline E Peterson, Phyllis A Rees, Magdalena Rutkowska, Bonnie M Slike, Christopher N Selverian, Isabella Swafford, I-Ting Teng, Paul V Thomas, Tongqing Zhou, Clayton J Smith, Jeffrey R Currier, Peter D Kwong, Morgane Rolland, Edgar Davidson, Benjamin J Doranz, Christopher N Mores, Theodora Hatziioannou, William W Reiley, Paul D Bieniasz, Dominic Paquin-Proulx, Gregory D Gromowski, Victoria R Polonis, Nelson L Michael, Kayvon Modjarrad, M Gordon Joyce, Shelly J Krebs

Journal: Nat Immunol

PubMed ID: 34716452

Doi: 10.1038/s41590-021-01068-z

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Identification and characterization of arginine kinase, a novel allergen that causes cross-reactivity among shellfish

Authors: Fei Huan, Tian-Jiao Han, Meng Liu, Meng-Si Li, Yang Yang, Qing-Mei Liu, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: Food Funct

PubMed ID: 34664604

Doi: 10.1039/d1fo02042k

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The selective degradation of sirtuins via macroautophagy in the MPP model of Parkinson's disease is promoted by conserved oxidation sites

Authors: Marius W Baeken, Mario Schwarz, Andreas Kern, Bernd Moosmann, Parvana Hajieva, Christian Behl

Journal: Cell Death Discov

PubMed ID: 34642296

Doi: 10.1038/s41420-021-00683-x

Products & Services: Mammalian Expression

Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence

Authors: Hillary A Vanderven, Robyn Esterbauer, Sinthujan Jegaskanda, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent

Journal: Immunol Cell Biol

PubMed ID: 34687553

Doi: 10.1111/imcb.12508

Products & Services: Mammalian Expression

Ultrasensitive Detection of SARS-CoV-2 Spike Proteins Using the Thio-NAD Cycling Reaction: A Preliminary Study before Clinical Trials

Authors: Yuta Kyosei, Mayuri Namba, Daiki Makioka, Ayumi Kokubun, Satoshi Watabe, Teruki Yoshimura, Tadahiro Sasaki, Tatsuo Shioda, Etsuro Ito

Journal: Microorganisms

PubMed ID: 34835340

Doi: 10.3390/microorganisms9112214

Products & Services: Mammalian Expression

Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation

Authors: Mounira Chalabi-Dchar, Elisabeth Cruz, Hichem C Mertani, Jean-Jacques Diaz, José Courty, Ilaria Cascone, Philippe Bouvet

Journal: Cancers (Basel)

PubMed ID: 34638443

Doi: 10.3390/cancers13194957

Products & Services: Mammalian Expression

Overexpression of a carrot BCH gene, DcBCH1, improves tolerance to drought in Arabidopsis thaliana

Authors: Tong Li, Jie-Xia Liu, Yuan-Jie Deng, Zhi-Sheng Xu, Ai-Sheng Xiong

Journal: BMC Plant Biol

PubMed ID: 34663216

Doi: 10.1186/s12870-021-03236-7

Products & Services: DNA Sequencing

Structural and allergenic properties of the Fatty Acid Binding Protein from shrimp Litopenaeus vannamei

Authors: Marlon Múnera, Dalgys Martínez, Judith Wortmann, Josefina Zakzuk, Walter Keller, Luis Caraballo, Leonardo Puerta

Journal: Allergy

PubMed ID: 34695231

Doi: 10.1111/all.15154

Products & Services: DNA Sequencing

Efficient Multi-Sites Genome Editing and Plant Regeneration Somatic Embryogenesis in

Authors: Ying Cui, Jian Zhao, Ying Gao, Ruirui Zhao, Jinfeng Zhang, Lisheng Kong

Journal: Front Plant Sci

PubMed ID: 34721480

Doi: 10.3389/fpls.2021.751891

Products & Services: DNA Sequencing

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Authors: Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 34718369

Doi: 10.1093/abbs/gmab143

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Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome

Authors: Amanda Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, Pilar Gonzalo, María J Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R Hamczyk, Álvaro Macías, Lara Del Campo, Emilio Camafeita, Jesús Vázquez, Anna Barkaway, Loïc Rolas, Sussan Nourshargh, Beatriz Dorado, Ignacio Benedicto, Vicente Andrés

Journal: Circulation

PubMed ID: 34694158

Doi: 10.1161/CIRCULATIONAHA.121.055313

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The ubiquitous buried water in the beta-trefoil architecture contributes to the folding nucleus and ~20% of the folding enthalpy

Authors: Joseph B Parker, Connie A Tenorio, Michael Blaber

Journal: Protein Sci

PubMed ID: 34562298

Doi: 10.1002/pro.4192

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Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector

Authors: Michiel van Diepen, Rosamund Chapman, Nicola Douglass, Leah Whittle, Nicole Chineka, Shireen Galant, Christian Cotchobos, Akiko Suzuki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34696239

Doi: 10.3390/vaccines9101131

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A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Authors: Kellan T Passow, Haley S Caldwell, Kiet A Ngo, Jamie J Arnold, Nicole M Antczak, Anoop Narayanan, Joyce Jose, Shana J Sturla, Craig E Cameron, Alexander T Ciota, Daniel A Harki

Journal: J Med Chem

PubMed ID: 34661397

Doi: 10.1021/acs.jmedchem.1c01481

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Mutational analysis of TlyA from Brachyspira hampsonii reveals two key residues conserved in pathogenic bacteria responsible for oligomerization and hemolytic activity

Authors: Brandon A Keith, John C S Harding, Matthew E Loewen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34715264

Doi: 10.1016/j.bbagen.2021.130045

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Repeating Aspartic Acid Residues Prefer Turn-like Conformations in the Unfolded State: Implications for Early Protein Folding

Authors: Bridget Milorey, Harald Schwalbe, Nichole O'Neill, Reinhard Schweitzer-Stenner

Journal: J Phys Chem B

PubMed ID: 34619031

Doi: 10.1021/acs.jpcb.1c06472

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Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures

Authors: Supriya Ravichandran, Gabrielle Grubbs, Juanjie Tang, Youri Lee, Chang Huang, Hana Golding, Surender Khurana

Journal: Sci Adv

PubMed ID: 34644111

Doi: 10.1126/sciadv.abi6533

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Synthetic virology: the experts speak

Authors:

Journal: Nat Biotechnol

PubMed ID: 34599304

Doi: 10.1038/s41587-021-01078-0

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Generation of recombinant vaccinia virus and analysis of virus-induced cell death

Authors: Zhijun Liu, Kidong Kang, Francis Ka-Ming Chan

Journal: STAR Protoc

PubMed ID: 34661172

Doi: 10.1016/j.xpro.2021.100871

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Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period

Authors: Wen-Heng Ji, Dan-Dan Li, Dan-Ping Wei, Ai-Qin Gu, Ying Yang, Jing-Pian Peng

Journal: Front Immunol

PubMed ID: 34712245

Doi: 10.3389/fimmu.2021.763067

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ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Authors: Hao Zhong, Jian Wang, Muhammad Adnan Hafeez, Rongfa Guan, Fengqin Feng

Journal: Front Nutr

PubMed ID: 34805244

Doi: 10.3389/fnut.2021.754222

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Natural diversity provides a broad spectrum of cyanobacteriochrome-based diguanylate cyclases

Authors: Matthew Blain-Hartung, Nathan C Rockwell, J Clark Lagarias

Journal: Plant Physiol

PubMed ID: 34608946

Doi: 10.1093/plphys/kiab240

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Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation

Authors: Aneta J Lenard, Saskia Hutten, Qishun Zhou, Sinem Usluer, Fangrong Zhang, Benjamin M R Bourgeois, Dorothee Dormann, Tobias Madl

Journal: Front Mol Biosci

PubMed ID: 34738012

Doi: 10.3389/fmolb.2021.689687

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Human serum albumin fusion protein as therapeutics for targeting amyloid beta in Alzheimer's diseases

Authors: Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, Kwan Hee Lee

Journal: Neurosci Lett

PubMed ID: 34673147

Doi: 10.1016/j.neulet.2021.136298

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Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo

Authors: Yuan Fang , Zezhong Liu , Yang Qiu , Jing Kong, Yuhong Fu, Yujie Liu , Chong Wang , Jia Quan , Qian Wang , Wei Xu , Lei Yin , Jie Cui , Yi Xu , Stephen Curry , Shibo Jiang , Lu Lu , Xi Zhou

Journal: Immunity

PubMed ID: 34555337

Doi: 10.1016/j.immuni.2021.08.027

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The Bacterial Amyloids Phenol Soluble Modulins from Catalyze Alpha-Synuclein Aggregation

Authors: Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E Otzen, Sara Linse, Jia-Yi Li

Journal: Int J Mol Sci

PubMed ID: 34769023

Doi: 10.3390/ijms222111594

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Drug Repurposing for the SARS-CoV-2 Papain-Like Protease

Authors: Chia-Chuan Cho, Shuhua G Li, Tyler J Lalonde, Kai S Yang, Ge Yu, Yuchen Qiao, Shiqing Xu, Wenshe Ray Liu

Journal: ChemMedChem

PubMed ID: 34423563

Doi: 10.1002/cmdc.202100455

Products & Services: Proteins, Expression, Isolation and Analysis

Guillain-Barré Syndrome Associated with COVID-19 Vaccination

Authors: Shih-Chieh Shao, Chien-Ho Wang, Kai-Cheng Chang, Ming-Jui Hung, Hui-Yu Chen, Shu-Chen Liao

Journal: Emerg Infect Dis

PubMed ID: 34648420

Doi: 10.3201/eid2712.211634

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative transcriptome analysis uncovers cell wall reorganization and repressed cell division during cotton fiber initiation

Authors: Wenyuan Liu, Yanjia Lv, Xiaoyue Li, Zongqin Feng, Lichen Wang

Journal: BMC Dev Biol

PubMed ID: 34715791

Doi: 10.1186/s12861-021-00247-3

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Reprogramming the metabolism of PCC 6803 by regulating the plastoquinone biosynthesis

Authors: Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu

Journal: Synth Syst Biotechnol

PubMed ID: 34754966

Doi: 10.1016/j.synbio.2021.10.004

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A BK channel-targeted peptide induces age-dependent improvement in behavioral and neural sound representation

Authors: Elliott J Brecht, Luisa L Scott, Bo Ding, Xiaoxia Zhu, Joseph P Walton

Journal: Neurobiol Aging

PubMed ID: 34861480

Doi: 10.1016/j.neurobiolaging.2021.10.014

Products & Services: Proteins, Expression, Isolation and Analysis

Overexpression of the Ginkgo biloba WD40 gene GbLWD1-like improves salt tolerance in transgenic Populus

Authors: Yue Xin, Yaqiong Wu, Xin Han, Li-An Xu

Journal: Plant Sci

PubMed ID: 34763876

Doi: 10.1016/j.plantsci.2021.111092

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WSB1 regulates c-Myc expression through -catenin signaling and forms a feedforward circuit

Authors: Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao

Journal: Acta Pharm Sin B

PubMed ID: 35530152

Doi: 10.1016/j.apsb.2021.10.021

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Prior infection with SARS-CoV-2 boosts and broadens Ad26COV2S immunogenicity in a variant-dependent manner

Authors: Roanne Keeton, Simone I Richardson, Thandeka Moyo-Gwete, Tandile Hermanus, Marius B Tincho, Ntombi Benede, Nelia P Manamela, Richard Baguma, Zanele Makhado, Amkele Ngomti, Thopisang Motlou, Mathilda Mennen, Lionel Chinhoyi, Sango Skelem, Hazel Maboreke, Deelan Doolabh, Arash Iranzadeh, Ashley D Otter, Tim Brooks, Mahdad Noursadeghi, James C Moon, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Jonathan Blackburn, Nei-Yuan Hsiao, Carolyn Williamson, Catherine Riou, Ameena Goga, Nigel Garrett, Linda-Gail Bekker, Glenda Gray, Ntobeko A B Ntusi, Penny L Moore, Wendy A Burgers

Journal: Cell Host Microbe

PubMed ID: 34688376

Doi: 10.1016/j.chom.2021.10.003

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An inducible -Cre mouse model to monitor and manipulate -highly-expressing senescent cells

Authors: Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia, George A Kuchel, James L Kirkland, Ming Xu

Journal: Nat Aging

PubMed ID: 35024619

Doi: 10.1038/s43587-021-00107-6

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Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus

Authors: Oscar A Ortega-Rivera, Sourabh Shukla, Matthew D Shin, Angela Chen, Veronique Beiss, Miguel A Moreno-Gonzalez, Yi Zheng, Alex E Clark, Aaron F Carlin, Jonathan K Pokorski, Nicole F Steinmetz

Journal: ACS Infect Dis

PubMed ID: 34672530

Doi: 10.1021/acsinfecdis.1c00410

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Polymersomes as Stable Nanocarriers for a Highly Immunogenic and Durable SARS-CoV-2 Spike Protein Subunit Vaccine

Authors: Jian Hang Lam, Amit K Khan, Thomas A Cornell, Teck Wan Chia, Regine J Dress, Wen Wang William Yeow, Nur Khairiah Mohd-Ismail, Shrinivas Venkataraman, Kim Tien Ng, Yee-Joo Tan, Danielle E Anderson, Florent Ginhoux, Madhavan Nallani

Journal: ACS Nano

PubMed ID: 34618423

Doi: 10.1021/acsnano.1c01243

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Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response

Authors: Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir

Journal: PLoS Pathog

PubMed ID: 34653226

Doi: 10.1371/journal.ppat.1010007

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Enzymatic extraction improves intracellular protein recovery from the industrial carrageenan seaweed revealed by quantitative, subcellular protein profiling: A high potential source of functional food ingredients

Authors: Simon Gregersen, Anne-Sofie Havgaard Kongsted, Rikke Brønnum Nielsen, Søren Storck Hansen, Frederik Andersen Lau, Jacob Bisgaard Rasmussen, Susan Løvstad Holdt, Charlotte Jacobsen

Journal: Food Chem X

PubMed ID: 34746746

Doi: 10.1016/j.fochx.2021.100137

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene Induced by Sound Stimulation Enhances Anthocyanin Accumulation in Grape Berry Skin through Direct Upregulation of UDP-Glucose: Flavonoid 3--Glucosyltransferase

Authors: Mone Yamazaki, Akari Ishida, Yutaka Suzuki, Yoshinao Aoki, Shunji Suzuki, Shinichi Enoki

Journal: Cells

PubMed ID: 34685779

Doi: 10.3390/cells10102799

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Reconstitution of Caveolin-1 into Artificial Lipid Membrane: Characterization by Transmission Electron Microscopy and Solid-State Nuclear Magnetic Resonance

Authors: Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang

Journal: Molecules

PubMed ID: 34684779

Doi: 10.3390/molecules26206201

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Using Continuous Directed Evolution to Improve Enzymes for Plant Applications

Authors: Jorge D García-García, Kristen Van Gelder, Jaya Joshi, Ulschan Bathe, Bryan J Leong, Steven D Bruner, Chang C Liu, Andrew D Hanson

Journal: Plant Physiol

PubMed ID: 34718794

Doi: 10.1093/plphys/kiab500

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A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom

Journal: biorxiv

PubMed ID: 34671768

Doi: 10.1101/2021.10.12.464114

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Recombinant expression of insoluble enzymes in Escherichia coli: a systematic review of experimental design and its manufacturing implications

Authors: Suraj Mital, Graham Christie, Duygu Dikicioglu

Journal: Microb Cell Fact

PubMed ID: 34717620

Doi: 10.1186/s12934-021-01698-w

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Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators

Authors: Luisa Vernizzi, Christian F Lehner

Journal: PLoS Genet

PubMed ID: 34669718

Doi: 10.1371/journal.pgen.1009870

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Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Authors: Hillary H Le, Suleyman S Cinaroglu, Elise C Manalo, Aysegul Ors, Michelle M Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A Origel Marmolejo, Arnaud Quentel, Justin S Plaut, Taryn E Kawashima, E Sila Ozdemir, Sanjay V Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C Saldivar, Emel Timucin, Jared M Fischer

Journal: EBioMedicine

PubMed ID: 34689087

Doi: 10.1016/j.ebiom.2021.103646

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Stabilized coronavirus spike stem elicits a broadly protective antibody

Authors: Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Jory A Goldsmith, Chia-Wei Chou, Olubukola M Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J Fritch, Kenneth H Dinnon, Alexandra Schäfer, Mark R Denison, James D Chappell, Ralph S Baric, Barney S Graham, Kizzmekia S Corbett, Jason S McLellan

Journal: Cell Rep

PubMed ID: 34710354

Doi: 10.1016/j.celrep.2021.109929

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Robust Neutralizing Antibody Responses 6 Months Post Vaccination with BNT162b2: A Prospective Study in 308 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sentiljana Gumeni, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Life (Basel)

PubMed ID: 34685448

Doi: 10.3390/life11101077

Characterization of oleosin genes from forage sorghum in Arabidopsis and yeast reveals their role in storage lipid stability

Authors: Rabishankar Ojha, Simranjit Kaur, Kshitija Sinha, Kirti Chawla, Sumandeep Kaur, Harish Jadhav, Manmehar Kaur, Rupam Kumar Bhunia

Journal: Planta

PubMed ID: 34655341

Doi: 10.1007/s00425-021-03744-8

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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins

Authors: Kristina V Boyko, Erin A Rosenkranz, Derrick M Smith, Heather L Miears, Melissa Oueld Es Cheikh, Micah Z Lund, Jeffery C Young, Patrick N Reardon, Mark Okon, Serge L Smirnov, John M Antos

Journal: PLoS ONE

PubMed ID: 34710113

Doi: 10.1371/journal.pone.0258531

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Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang, Sheng Zhang

Journal: Cancer Cell Int

PubMed ID: 34663350

Doi: 10.1186/s12935-021-02257-4

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Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies

Authors: Andrew T Chen, Hannah D Stacey, Art Marzok, Pardeep Singh, Jann Ang, Matthew S Miller, Mark Loeb

Journal: Vaccine

PubMed ID: 34756613

Doi: 10.1016/j.vaccine.2021.10.021

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Authors: Jazmine P Hallinan, Lindsey A Doyle, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

Journal: Commun Biol

PubMed ID: 34716407

Doi: 10.1038/s42003-021-02766-y

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Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway

Authors: Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu

Journal: Evid Based Complement Alternat Med

PubMed ID: 34646326

Doi: 10.1155/2021/5561999

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Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

Journal: Biol Direct

PubMed ID: 34674770

Doi: 10.1186/s13062-021-00305-7

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