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LDH nanoparticle adjuvant subunit vaccine induces an effective immune response for porcine epidemic diarrhea virus

Authors: Danyi Shi, Baochao Fan, Bing Sun, Jinzhu Zhou, Yongxiang Zhao, Rongli Guo, Zengjun Ma, Tao Song, Huiying Fan, Jizong Li, Li Li, Bin Li

Journal: Virology

PubMed ID: 34739917

Doi: 10.1016/j.virol.2021.10.010

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Polyactin A and CpG enhance inactivated Pseudomonas plecoglossicida vaccine potency in large yellow croaker (Larimichthys crocea)

Authors: Wenwen Wang, Wei Wang, Wenjun Xu, Qin Liu, Yuanxing Zhang, Xiaohong Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34780977

Doi: 10.1016/j.fsi.2021.11.008

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STING inhibition accelerates the bone healing process while enhancing type H vessel formation

Authors: Xiaojun Chen, Wenxin He, Mengzhe Sun, Yingjie Yan, Yichuan Pang, Gang Chai

Journal: FASEB J

PubMed ID: 34694030

Doi: 10.1096/fj.202100069RR

Products & Services: Nucleic Acid Purification & Analysis

Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

Authors: Kamela O Alegre, Navid Paknejad, Minfei Su, Jian-Shu Lou, Jianyun Huang, Kelsey D Jordan, Edward T Eng, Joel R Meyerson, Richard K Hite, Xin-Yun Huang

Journal: Nat Struct Mol Biol

PubMed ID: 34759376

Doi: 10.1038/s41594-021-00679-2

Products & Services: Mutant Libraries

Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway

Authors: Yue Shi, Chong Liu

Journal: BMC Cancer

PubMed ID: 34800978

Doi: 10.1186/s12885-021-08989-w

Products & Services: Mutant Libraries

Mapping enzyme catalysis with metabolic biosensing

Authors: Linfeng Xu, Kai-Chun Chang, Emory M Payne, Cyrus Modavi, Leqian Liu, Claire M Palmer, Nannan Tao, Hal S Alper, Robert T Kennedy, Dale S Cornett, Adam R Abate

Journal: Nat Commun

PubMed ID: 34815408

Doi: 10.1038/s41467-021-27185-9

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SpSR-B2 functions as a potential pattern recognition receptor involved in antiviral and antibacterial immune responses of mud crab Scylla paramamosain

Authors: Jian Zhou, Jun-Fang Zhou, Yue Wang, Guang-Peng Feng, Wen-Hong Fang, Wei Kang, Ling-Bo Ma, Xin-Cang Li

Journal: Int J Biol Macromol

PubMed ID: 34780895

Doi: 10.1016/j.ijbiomac.2021.11.048

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Photoredox-Catalyzed Decarboxylative -Terminal Differentiation for Bulk- and Single-Molecule Proteomics

Authors: Le Zhang, Brendan M Floyd, Maheshwerreddy Chilamari, James Mapes, Jagannath Swaminathan, Steven Bloom, Edward M Marcotte, Eric V Anslyn

Journal: ACS Chem Biol

PubMed ID: 34734691

Doi: 10.1021/acschembio.1c00631

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Elevated Fab glycosylation of anti-hinge antibodies

Authors: J Koers, Nil Derksen, Wjj Falkenburg, P Ooijevaar-de Heer, M T Nurmohamed, G J Wolbink, T Rispens

Journal: Scand J Rheumatol

PubMed ID: 34726124

Doi: 10.1080/03009742.2021.1986959

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Using recombinant adhesive proteins as durable and green flame-retardant coatings

Authors: Weng I Leong, Owen Lok In Lo, Fong Tin Cheng, Wai Man Cheong, Leo Chi U Seak

Journal: Synth Syst Biotechnol

PubMed ID: 34786512

Doi: 10.1016/j.synbio.2021.10.005

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Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved in -Terphenyl Biosynthesis

Authors: Jonathan A Clinger, Yinan Zhang, Yang Liu, Mitchell D Miller, Ronnie E Hall, Steven G Van Lanen, George N Phillips, Jon S Thorson, Sherif I Elshahawi

Journal: ACS Chem Biol

PubMed ID: 34763417

Doi: 10.1021/acschembio.1c00701

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Biodegradation of diphenyl ether herbicide lactofen by Bacillus sp YS-1 and characterization of two initial degrading esterases

Authors: Na Shang, Lingling Chen, Minggen Cheng, Yanning Tian, Xing Huang

Journal: Sci Total Environ

PubMed ID: 34742792

Doi: 10.1016/j.scitotenv.2021.151357

Products & Services: DNA Sequencing

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

Authors: Deepali Gupta, Priyanka Sharma, Mandeep Singh, Mukesh Kumar, A S Ethayathulla, Punit Kaur

Journal: Cell Mol Life Sci

PubMed ID: 34731254

Doi: 10.1007/s00018-021-04008-0

Products & Services: DNA Sequencing

Prokaryotic expression, evaluation, and prediction of the structure and function of the ecarin metalloproteinase domain

Authors: Nasrin Mohammadi, Mojgan Bandehpour, Fattah Sotoodehnejadnematalahi, Bahram Kazemi

Journal: Proteins

PubMed ID: 34739152

Doi: 10.1002/prot.26275

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African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis

Authors: Tingting Li, Gaihong Zhao, Taoqing Zhang, Zhaoxia Zhang, Xin Chen, Jie Song, Xiao Wang, Jiangnan Li, Li Huang, Lili Wen, Changyao Li, Dongming Zhao, Xijun He, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: Viruses

PubMed ID: 34835046

Doi: 10.3390/v13112240

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5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos

Authors: Luxi Chen, Wei Xu, Kunpeng Liu, Zheng Jiang, Yang Han, Hongbin Jin, Lin Zhang, Weimin Shen, Shunji Jia, Qianwen Sun, Anming Meng

Journal: Sci Adv

PubMed ID: 34797706

Doi: 10.1126/sciadv.abh0494

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Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway

Authors: Xiaohan Luan, Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun

Journal: FASEB J

PubMed ID: 34606626

Doi: 10.1096/fj.202101044RRR

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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA

Authors: Alicia K Byrd, Emory G Malone, Lindsey Hazeslip, Maroof Khan Zafar, David K Harrison, Matthew D Thompson, Jun Gao, Senthil K Perumal, John C Marecki, Kevin D Raney

Journal: Protein Sci

PubMed ID: 34761452

Doi: 10.1002/pro.4232

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Identification and Characterization of Antigen-Specific CD8 T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing

Authors: Shaheed Abdulhaqq, Abigail B Ventura, Jason S Reed, Arman A Bashirova, Katherine B Bateman, Eric McDonald, Helen L Wu, Justin M Greene, John B Schell, David Morrow, Karin Wisskirchen, Jeffrey N Martin, Steven G Deeks, Mary Carrington, Ulrike Protzer, Klaus Früh, Scott G Hansen, Louis J Picker, Jonah B Sacha, Benjamin N Bimber

Journal: J Immunol

PubMed ID: 34810222

Doi: 10.4049/jimmunol.2100535

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The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States

Authors: Andrew Bogard, Pangaea W Finn, Fulton McKinney, Ilinca M Flacau, Aviana R Smith, Rosey Whiting, Daniel Fologea

Journal: Membranes (Basel)

PubMed ID: 34832126

Doi: 10.3390/membranes11110897

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SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Authors: Jesse D Deere, Timothy D Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L Yee, Katherine J Olstad, J Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Graham Simmons, Jennifer Watanabe, Rachel E Pollard, Jodie Usachenko, Ramya Immareddy, Brian A Schmidt, Shelby L O'Connor, Joseph DeRisi, Michael P Busch, Smita S Iyer, Koen K A Van Rompay, Dennis J Hartigan-O'Connor, Christopher J Miller

Journal: Microbiol Spectr

PubMed ID: 34817208

Doi: 10.1128/Spectrum.01397-21

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Retinol-Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3

Authors: Kang-Zhen Zhang, Xi-Yu Shen, Man Wang, Li Wang, Hui-Xian Sun, Xiu-Zhen Li, Jing-Jing Huang, Xiao-Qing Li, Cheng Wu, Can Zhao, Jia-Li Liu, Xiang Lu, Wei Gao

Journal: J Am Heart Assoc

PubMed ID: 34726071

Doi: 10.1161/JAHA.121.022011

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Management of COVID patients with convalescent plasma: Do we have the final word?

Authors: Francesco Menichetti, Marco Falcone, Giusy Tiseo

Journal: Eur J Intern Med

PubMed ID: 34895816

Doi: 10.1016/j.ejim.2021.10.029

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A study of cobalt (II) complexes involved in marine biogeochemical processes: Co(II)-1,10-Phenanthroline and Co(II)-1,10-Phenanthroline-L-α-Phosphatidylcholine

Authors: Anđela Bačinić, Sanja Frka, Marina Mlakar

Journal: Bioelectrochemistry

PubMed ID: 34902665

Doi: 10.1016/j.bioelechem.2021.108009

Products & Services: Peptide Synthesis

Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies

Authors: Anilkumar Gopalakrishnapillai, Colin E Correnti, Kristina Pilat, Ida Lin, Man Kid Chan, Ashok D Bandaranayake, Christopher Mehlin, Anne Kisielewski, Darcy Hamill, Allison J Kaeding, Soheil Meshinchi, James M Olson, Edward Anders Kolb, Sonali P Barwe

Journal: Cancers (Basel)

PubMed ID: 34885074

Doi: 10.3390/cancers13235964

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Overexpression of N-acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation

Authors: Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou

Journal: J Cell Physiol

PubMed ID: 34806177

Doi: 10.1002/jcp.30641

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleic Acid Delivery from Granular Hydrogels

Authors: Evan Kurt, Tatiana Segura

Journal: Adv Healthc Mater

PubMed ID: 34742164

Doi: 10.1002/adhm.202101867

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates

Authors: Marco Raabe, Astrid Johanna Heck, Siska Führer, Dominik Schauenburg, Michaela Pieszka, Tao Wang, Maksymilian Marek Zegota, Lutz Nuhn, David Y W Ng, Seah Ling Kuan, Tanja Weil

Journal: Macromol Biosci

PubMed ID: 34791790

Doi: 10.1002/mabi.202100299

Products & Services: Proteins, Expression, Isolation and Analysis

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

Authors: Juan Luis Pacheco-Garcia, Dmitry Loginov, Bruno Rizzuti, Pavla Vankova, Jose L Neira, Daniel Kavan, Noel Mesa-Torres, Rita Guzzi, Petr Man, Angel L Pey

Journal: FEBS Lett

PubMed ID: 34817874

Doi: 10.1002/1873-3468.14238

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Genomic structure, expression, and functional characterization of the Fem-1 gene family in the redclaw crayfish, Cherax quadricarinatus

Authors: Jianbo Zheng, Leran Chen, Yongyi Jia, Meili Chi, Fei Li, Shun Cheng, Shili Liu, Yinuo Liu, Zhimin Gu

Journal: Gen Comp Endocrinol

PubMed ID: 34861280

Doi: 10.1016/j.ygcen.2021.113961

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Commensal Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines

Authors: Michele Tomasi, Mattia Dalsass, Francesco Beghini, Ilaria Zanella, Elena Caproni, Laura Fantappiè, Assunta Gagliardi, Carmela Irene, Enrico König, Luca Frattini, Giulia Masetti, Samine Jessica Isaac, Federica Armanini, Fabio Cumbo, Aitor Blanco-Míguez, Alberto Grandi, Nicola Segata, Guido Grandi

Journal: Vaccines (Basel)

PubMed ID: 34835287

Doi: 10.3390/vaccines9111356

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Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Authors: Marcel V Alavi

Journal: Biochim Biophys Acta Mol Cell Res.

PubMed ID: 34400172

Doi: 10.1016/j.bbamcr.2021.119116

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Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Authors: Sai Shashank Chavali, Sachitanand M Mali, Rachel Bonn, Abhijith Saseendran Anitha, Ryan P Bennett, Harold C Smith, Rudi Fasan, Joseph E Wedekind

Journal: J Biol Chem.

PubMed ID: 34767799

Doi: 10.1016/j.jbc.2021.101390

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Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Authors: Martin J Fossat, Ammon E Posey, Rohit V Pappu

Journal: Biophys J

PubMed ID: 34826385

Doi: 10.1016/j.bpj.2021.11.2886

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Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma

Authors: Ai-Ai Luan, Ling-Ling Hou, Fang-Yuan Zhang

Journal: Kaohsiung J Med Sci

PubMed ID: 34850542

Doi: 10.1002/kjm2.12479

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Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha

Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen

Journal: J Stroke Cerebrovasc Dis

PubMed ID: 34837757

Doi: 10.1016/j.jstrokecerebrovasdis.2021.106221

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The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells

Authors: Takwa S Aroankins, Sathish K Murali, Robert A Fenton, Qi Wu

Journal: Front Mol Biosci

PubMed ID: 34881291

Doi: 10.3389/fmolb.2021.790606

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Characterization of the interaction domains between the phosphoprotein and the nucleoprotein of human Metapneumovirus

Authors: Hortense Decool, Benjamin Bardiaux, Luis Checa Ruano, Olivier Sperandio, Jenna Fix, Irina Gutsche, Charles-Adrien Richard, Monika Bajorek, Jean-François Eléouët, Marie Galloux

Journal: J Virol

PubMed ID: 34730389

Doi: 10.1128/JVI.00909-21

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Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow

Authors: Kyong Hoon Kim, Aryeong Choi, Sang Hoon Kim, Heonju Song, Seohoon Jin, Kyungim Kim, Jaebong Jang, Hanbyeul Choi, Yong Woo Jung

Journal: Mol Cells

PubMed ID: 34819396

Doi: 10.14348/molcells.2021.0137

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Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia

Authors: Ting Zhu, Bo Liu, Di Wu, Gang Xu, Yang Fan

Journal: Front Cell Dev Biol

PubMed ID: 34869326

Doi: 10.3389/fcell.2021.740884

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A poly(ethylene glycol) three-dimensional bone marrow hydrogel

Authors: Lauren E Jansen, Hyuna Kim, Christopher L Hall, Thomas P McCarthy, Michael J Lee, Shelly R Peyton

Journal: Biomaterials

PubMed ID: 34890973

Doi: 10.1016/j.biomaterials.2021.121270

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Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

Authors: Ria Goswami, Veronica S Russell, Joshua J Tu, Charlene Thomas, Philip Hughes, Francine Kelly, Stephanie N Langel, Justin Steppe, Scott M Palmer, Timothy Haystead, Maria Blasi, Sallie R Permar

Journal: iScience

PubMed ID: 34786537

Doi: 10.1016/j.isci.2021.103412

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Fabrication of MERS-nanovesicle biosensor composed of multi-functional DNA aptamer/graphene-MoS nanocomposite based on electrochemical and surface-enhanced Raman spectroscopy

Authors: Gahyeon Kim, Jinmyeong Kim, Soo Min Kim, Tatsuya Kato, Jinho Yoon, Seungwoo Noh, Enoch Y Park, Chulhwan Park, Taek Lee, Jeong-Woo Choi

Journal: Sens Actuators B Chem

PubMed ID: 34785863

Doi: 10.1016/j.snb.2021.131060

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Genome-wide identification and characteristic analysis of the downstream melatonin metabolism gene GhM2H in Gossypium hirsutum L

Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei, Wuwei Ye

Journal: Biol Res

PubMed ID: 34736526

Doi: 10.1186/s40659-021-00358-y

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LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

Authors: Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Perez Gutierrez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K Wang, Napoleone Ferrara

Journal: EMBO Mol Med

PubMed ID: 34779136

Doi: 10.15252/emmm.202114511

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Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Authors: Yuan Tian, Yi Wang, Angela M Jablonski, Yinghui Hu, Jonathan A Sugam, Markus Koglin, Shawn J Stachel, Heather Zhou, Jason M Uslaner, Sophie Parmentier-Batteur

Journal: Neurobiol Dis

PubMed ID: 34752923

Doi: 10.1016/j.nbd.2021.105548

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Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation

Authors: Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang

Journal: Protein Cell

PubMed ID: 34731408

Doi: 10.1007/s13238-021-00884-1

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Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway

Authors: Zi-Tan Peng, Pei Gu

Journal: Hum Exp Toxicol

PubMed ID: 34749521

Doi: 10.1177/09603271211054437

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Biosynthesis of Poly(3HB--3HP) with Variable Monomer Composition in Recombinant H16

Authors: Callum McGregor, Nigel P Minton, Katalin Kovács

Journal: ACS Synth Biol

PubMed ID: 34762808

Doi: 10.1021/acssynbio.1c00283

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A Genome-Phenome Association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

Authors: Weiwei Yang, Yu-Cheng Lin, William Johnson, Nan Dai, Romualdas Vaisvila, Peter Weigele, Yan-Jiun Lee, Ivan R Corrêa, Ira Schildkraut, Laurence Ettwiller

Journal: Elife

PubMed ID: 34747693

Doi: 10.7554/eLife.70021

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Poor neutralizing antibody responses in 106 patients with WM after vaccination against SARS-CoV-2: a prospective study

Authors: Maria Gavriatopoulou, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Panagiotis Malandrakis, Despina Fotiou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Blood Adv

PubMed ID: 34529762

Doi: 10.1182/bloodadvances.2021005444

The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome

Authors: Yanqiu Yue, Fengbin Jin, Xiaohui Yue

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 34933712

Doi: 10.14715/cmb/2021.67.3.28

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SNHG17, as an EMT-related lncRNA, promotes the expression of c-Myc by binding to c-Jun in esophageal squamous cell carcinoma

Authors: Supeng Shen, Jia Liang, Xiaoliang Liang, Gaoyan Wang, Bo Feng, Wei Guo, Yanli Guo, Zhiming Dong

Journal: Cancer Sci

PubMed ID: 34714590

Doi: 10.1111/cas.15184

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Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells

Authors: Wei Li, Yanqiu Zhang, Jifeng Xu, Jincan Chen, Xia Gao

Journal: Exp Ther Med

PubMed ID: 34849158

Doi: 10.3892/etm.2021.10965

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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

Authors: Yusuf I Ertuna, Benedict Fallet, Anna-Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D Pinschewer

Journal: Cell Rep

PubMed ID: 34852228

Doi: 10.1016/j.celrep.2021.110061

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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells

Authors: Opeyemi S Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M Chew, Cecilia Shikuma, Costin Tomescu, Ashley F George, Nadia R Roan, Lishomwa C Ndhlovu, Qin Liu, Kar Muthumani, David B Weiner, Michael R Betts, Han Xiao, Mohamed Abdel-Mohsen

Journal: PLoS Pathog

PubMed ID: 34762717

Doi: 10.1371/journal.ppat.1010034

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Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation

Authors: Qisheng Zuo, Jin Jing, Jing Zhou, Yani Zhang, Wanhong Wei, Guohong Chen, Bichun Li

Journal: EMBO Rep

PubMed ID: 34747116

Doi: 10.15252/embr.202152491

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Genome-Wide Identification, Characterization and Expression Analysis of Soybean Gene Family

Authors: Bowei Jia, Yan Wang, Dajian Zhang, Wanhong Li, Hongli Cui, Jun Jin, Xiaoxi Cai, Yang Shen, Shengyang Wu, Yongxia Guo, Mingzhe Sun, Xiaoli Sun

Journal: Int J Mol Sci

PubMed ID: 34830077

Doi: 10.3390/ijms222212192

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Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments

Authors: Stephen J Winter, Hunter A Miller, Jill M Steinbach-Rankins

Journal: Pharmaceutics

PubMed ID: 34834307

Doi: 10.3390/pharmaceutics13111891

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Understanding the Role of Genus in the Digestion of Lignocellulose and Other Substrates in Vietnamese Native Goats' Rumen by Metagenomic Deep Sequencing

Authors: Trong-Khoa Dao, Thi-Huyen Do, Ngoc-Giang Le, Hong-Duong Nguyen, Thi-Quy Nguyen, Thi-Thu-Hong Le, Nam-Hai Truong

Journal: Animals (Basel)

PubMed ID: 34827987

Doi: 10.3390/ani11113257

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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Authors: Daniel Franjic, Mario Skarica, Shaojie Ma, Jon I Arellano, Andrew T N Tebbenkamp, Jinmyung Choi, Chuan Xu, Qian Li, Yury M Morozov, David Andrijevic, Zvonimir Vrselja, Ana Spajic, Gabriel Santpere, Mingfeng Li, Shupei Zhang, Yang Liu, Joshua Spurrier, Le Zhang, Ivan Gudelj, Lucija Rapan, Hideyuki Takahashi, Anita Huttner, Rong Fan, Stephen M Strittmatter, Andre M M Sousa, Pasko Rakic, Nenad Sestan

Journal: Neuron

PubMed ID: 34798047

Doi: 10.1016/j.neuron.2021.10.036

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Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

Authors: Hongyu Qiu, Xin-Yong Yuan, Teresa Cabral, Kathy Manguiat, Alyssia Robinson, Heidi Wood, Chris Grant, Peter McQueen, Garrett Westmacott, Daniel R Beniac, Lisa Lin, Michael Carpenter, Darwyn Kobasa, Tom Gräfenhan

Journal: Antiviral Res

PubMed ID: 34762975

Doi: 10.1016/j.antiviral.2021.105206

Products & Services: Proteins, Expression, Isolation and Analysis

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

Authors: Natalya Pashkova, Lokesh Gakhar, Liping Yu, Nicholas J Schnicker, Annabel Y Minard, Stanley Winistorfer, Ivan E Johnson, Robert C Piper

Journal: Elife

PubMed ID: 34821552

Doi: 10.7554/eLife.72583

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Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2

Authors: Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, Ping Zhang, Xujun Xuan, Peiyi Wang, Zhiqiang Liu, Boda Zhou, Maojun Yang

Journal: Cell Discov

PubMed ID: 34728622

Doi: 10.1038/s41421-021-00334-6

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BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2

Authors: R Camille Brewer, Nitya S Ramadoss, Lauren J Lahey, Shaghayegh Jahanbani, William H Robinson, Tobias V Lanz

Journal: Nat Immunol

PubMed ID: 34848871

Doi: 10.1038/s41590-021-01088-9

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EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Authors: Toshinori Ando, Nadia Arang, Zhiyong Wang, Daniela Elena Costea, Xiaodong Feng, Yusuke Goto, Hiroki Izumi, Mara Gilardi, Kazuyo Ando, J Silvio Gutkind

Journal: Commun Biol

PubMed ID: 34725466

Doi: 10.1038/s42003-021-02744-4

Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket

Authors: Dinesh M Fernando, Clifford T Gee, Elizabeth C Griffith, Christopher J Meyer, Laura A Wilt, Rajendra Tangallapally, Miranda J Wallace, Darcie J Miller, Richard E Lee

Journal: Tuberculosis (Edinb)

PubMed ID: 34894561

Doi: 10.1016/j.tube.2021.102157

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Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

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Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs

Authors: Anjali Y Bhagirath, Vikram Bhatia, Manoj Reddy Medapati, Nisha Singh, Martha Hinton, Prashen Chelikani, Shyamala Dakshinamurti

Journal: FASEB Bioadv

PubMed ID: 35664968

Doi: 10.1096/fba.2021-00073

Products & Services: Mammalian Expression

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD/SIRT6 axis

Authors: Christopher A Koczor, Kate M Saville, Joel F Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V Makarov, Marie E Migaud, Robert W Sobol

Journal: Cell Rep

PubMed ID: 34731617

Doi: 10.1016/j.celrep.2021.109917

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Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

Authors: Hsiang-Chi Huang, Yun-Ju Lai, Chun-Che Liao, Wang-Feng Yang, Ke-Bin Huang, I-Jung Lee, Wen-Cheng Chou, Shih-Han Wang, Ling-Hui Wang, Jung-Mao Hsu, Cheng-Pu Sun, Chun-Tse Kuo, Jyun Wang, Tzu-Chun Hsiao, Po-Jiun Yang, Te-An Lee, Wilson Huang, Fu-An Li, Chen-Yang Shen, Yi-Ling Lin, Mi-Hua Tao, Chia-Wei Li

Journal: EBioMedicine

PubMed ID: 34839261

Doi: 10.1016/j.ebiom.2021.103712

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid Response to SARS-CoV-2 in Aotearoa New Zealand: Implementation of a Diagnostic Test and Characterization of the First COVID-19 Cases in the South Island

Authors: Blair Lawley, Jenny Grant, Rhodri Harfoot, Jackson M Treece, Robert Day, Leonor C Hernández, Jo-Ann L Stanton, James E Ussher, Miguel E Quiñones-Mateu

Journal: Viruses

PubMed ID: 34835031

Doi: 10.3390/v13112222

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MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Authors: Avelino C Verceles, Pavan Bhat, Zain Nagaria, Destiny Martin, Harsh Patel, Afua Ntem-Mensah, Sang W Hyun, Andrea Hahn, Jean Jeudy, Alan S Cross, Erik P Lillehoj, Simeon E Goldblum

Journal: Sci Rep

PubMed ID: 34811449

Doi: 10.1038/s41598-021-02242-x

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An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

Authors: Dengning Xia, Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M Saad Bhamla, Chinglai Yang, Mark R Prausnitz

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34670842

Doi: 10.1073/pnas.2110817118

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Development and Characterization of Magnetic SARS-CoV-2 Peptide-Imprinted Polymers

Authors: Beatriz Fresco-Cala, Soumya Rajpal, Tamara Rudolf, Benedikt Keitel, Rüdiger Groß, Jan Münch, Alex D Batista, Boris Mizaikoff

Journal: Nanomaterials (Basel)

PubMed ID: 34835749

Doi: 10.3390/nano11112985

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Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival

Authors: Fiamma Berner, Rebekka Niederer, Jolien J Luimstra, Oltin Tiberiu Pop, Ann-Kristin Jochum, Mette-Triin Purde, Omar Hasan Ali, David Bomze, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marissa Lisa Dubbelaar, Marie-Therese Abdou, Petra Baumgaertner, Christina Appenzeller, Caroline Cicin-Sain, Tobias Lenz, Daniel E Speiser, Burkhard Ludewig, Christoph Driessen, Markus Jörger, Martin Früh, Wolfram Jochum, Antonio Cozzio, Hans-Georg Rammensee, Juliane Walz, Jacques Neefjes, Lukas Flatz

Journal: Oncoimmunology

PubMed ID: 34858733

Doi: 10.1080/2162402X.2021.2006893

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Lipid-Binding Aegerolysin from Biocontrol Fungus

Authors: Nada Kraševec, Anastasija Panevska, Špela Lemež, Jaka Razinger, Kristina Sepčić, Gregor Anderluh, Marjetka Podobnik

Journal: Toxins (Basel)

PubMed ID: 34822604

Doi: 10.3390/toxins13110820

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Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Authors: Elwood A Mullins, Jonathan Dorival, Gong-Li Tang, Dale L Boger, Brandt F Eichman

Journal: Nat Commun

PubMed ID: 34836957

Doi: 10.1038/s41467-021-27284-7

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VviPLATZ1 is a major factor that controls female flower morphology determination in grapevine

Authors: Pat Iocco-Corena, Jamila Chaïb, Laurent Torregrosa, Don Mackenzie, Mark R Thomas, Harley M Smith

Journal: Nat Commun

PubMed ID: 34848714

Doi: 10.1038/s41467-021-27259-8

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells

Authors: Wenjia Peng, Shuai Li, Shiyue Chen, Jiacheng Yang, Ze Sun

Journal: Front Cardiovasc Med

PubMed ID: 34912856

Doi: 10.3389/fcvm.2021.731890

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Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

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Surrogate test performance for SARS-CoV-2 neutralizing antibodies (nAbs) for convalescent plasma (CCP): How useful could they be?

Authors: Silvano Wendel, Roberta Fachini, Rita C L Fontão-Wendel, Ralyria Mello, Carlos Vinícius Velasquez, Rafael Rahal Guaragna Machado, Mayra Altobelli Brito, Marcelo Amaral, Camila Pereira Soares, Ruth Achkar, Patrícia Scuracchio, Sandra Cristina Miyaji, Melina Santos Erdens, Edison Luiz Durigon

Journal: Transfusion

PubMed ID: 34674284

Doi: 10.1111/trf.16714

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Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: medrxiv

PubMed ID: 34729569

Doi: 10.1101/2021.10.27.21265561

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Comparing Five SARS-CoV-2 Antibody Assay Results Before and After the First and Second ChAdOx1 nCoV-19 Vaccination Among Health Care Workers: A Prospective Multicenter Study

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34613799

Doi: 10.1128/JCM.01788-21

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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Authors: Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan

Journal: Sci Transl Med

PubMed ID: 34519517

Doi: 10.1126/scitranslmed.abj5413

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SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

Authors: Maoquan Li, Jinqiu Ning, Jiwei Wang, Qiqian Yan, Ke Zhao, Xiaoshi Jia

Journal: Int J Mol Med

PubMed ID: 34617577

Doi: 10.3892/ijmm.2021.5043

Products & Services: Proteins, Expression, Isolation and Analysis

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Authors: Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B Sanz-Martos, Francisco Zafra

Journal: Cell Mol Life Sci

PubMed ID: 34709416

Doi: 10.1007/s00018-021-03998-1

Products & Services: Proteins, Expression, Isolation and Analysis

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Authors: Guha Asthagiri Arunkumar, Disha Bhavsar, Tiehai Li, Shirin Strohmeier, Veronika Chromikova, Fatima Amanat, Mehman Bunyatov, Patrick C Wilson, Ali H Ellebedy, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Florian Krammer

Journal: Nat Commun

PubMed ID: 34697321

Doi: 10.1038/s41467-021-26409-2

Products & Services: Proteins, Expression, Isolation and Analysis

Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway

Authors: Xin Lin, Yong Zhu, Guohui Le

Journal: J Interferon Cytokine Res

PubMed ID: 34698528

Doi: 10.1089/jir.2021.0083

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of From the Marine Crab and Its Functions Under Low Salinity Conditions

Authors: Xianyun Ren, Lei Wang, Yao Xu, Qiong Wang, Jianjian Lv, Ping Liu, Jian Li

Journal: Front Physiol

PubMed ID: 34744765

Doi: 10.3389/fphys.2021.724693

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic Engineering of for Improved 2,3-Butanediol Production by Manipulating NADH Levels and Overexpressing the Small RNA RyhB

Authors: Yan Wu, Wanying Chu, Jiayao Yang, Yudong Xu, Qi Shen, Haoning Yang, Fangxu Xu, Yefei Liu, Ping Lu, Ke Jiang, Hongxin Zhao

Journal: Front Microbiol

PubMed ID: 34691005

Doi: 10.3389/fmicb.2021.754306

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The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice

Authors: Guendalina Zaccaria, Daniela Malatesta, Lucija Jurisic, Maurilia Marcacci, Giovanni Di Teodoro, Annamaria Conte, Liana Teodori, Federica Monaco, Valeria Marini, Claudia Casaccia, Giovanni Savini, Annapia Di Gennaro, Emanuela Rossi, Vincenzo D'Innocenzo, Nicola D'Alterio, Alessio Lorusso

Journal: Vet Microbiol

PubMed ID: 34715462

Doi: 10.1016/j.vetmic.2021.109262

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Novel Phage-Derived Depolymerase with Activity against Biofilms

Authors: Cormac J Rice, Stephen A Kelly, Seamus C O'Brien, Erinn M Melaugh, Jan C B Ganacias, Zheng Hua Chai, Brendan F Gilmore, Timofey Skvortsov

Journal: Microorganisms

PubMed ID: 34683494

Doi: 10.3390/microorganisms9102172

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Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection

Authors: Yin Liu, Yanling Chen, Shisheng Huang, Xiaodong Ma, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Frontiers

Doi: 10.3389/fmolb.2021.753276

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Regulate the hydrophobic motif to enhance the non-classical secretory expression of Pullulanase PulA in Bacillus subtilis

Authors: Jie Zhen, Hongchen Zheng, Xingya Zhao, Xiaoping Fu, Shibin Yang, Jianyong Xu, Hui Song, Yanhe Ma

Journal: Int J Biol Macromol

PubMed ID: 34710472

Doi: 10.1016/j.ijbiomac.2021.10.164

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Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Authors: Kazuhiro Kobuke, Kenji Oki, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez, Kiyotaka Itcho, Haruya Ohno, Gaku Nagano, Yoko Yoshii, Ryuta Baba, Takaya Kodama, Koji Arihiro, Noboru Hattori, Masayasu Yoneda

Journal: Int J Mol Sci

PubMed ID: 34681640

Doi: 10.3390/ijms222010981

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Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel

Authors: Ying Wang, Yi-Chi Zhang, Ke-Xin Zhang, Zhong-Qiang Jia, Tao Tang, Lin-Lin Zheng, Di Liu, Chun-Qing Zhao

Journal: Pest Manag Sci

PubMed ID: 34619015

Doi: 10.1002/ps.6669

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FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2

Authors: Jenna M DeLuca, Maegan K Murphy, Xin Wang, Timothy J Wilson

Journal: J Immunol

PubMed ID: 34697226

Doi: 10.4049/jimmunol.2100218

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Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Authors: Vincent Dussupt, Rajeshwer S Sankhala, Letzibeth Mendez-Rivera, Samantha M Townsley, Fabian Schmidt, Lindsay Wieczorek, Kerri G Lal, Gina C Donofrio, Ursula Tran, Nathaniel D Jackson, Weam I Zaky, Michelle Zemil, Sarah R Tritsch, Wei-Hung Chen, Elizabeth J Martinez, Aslaa Ahmed, Misook Choe, William C Chang, Agnes Hajduczki, Ningbo Jian, Caroline E Peterson, Phyllis A Rees, Magdalena Rutkowska, Bonnie M Slike, Christopher N Selverian, Isabella Swafford, I-Ting Teng, Paul V Thomas, Tongqing Zhou, Clayton J Smith, Jeffrey R Currier, Peter D Kwong, Morgane Rolland, Edgar Davidson, Benjamin J Doranz, Christopher N Mores, Theodora Hatziioannou, William W Reiley, Paul D Bieniasz, Dominic Paquin-Proulx, Gregory D Gromowski, Victoria R Polonis, Nelson L Michael, Kayvon Modjarrad, M Gordon Joyce, Shelly J Krebs

Journal: Nat Immunol

PubMed ID: 34716452

Doi: 10.1038/s41590-021-01068-z

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