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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

Products & Services: Plasmid DNA Preparation

Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily

Authors: Kyrylo Yu Manoilov, Agnidipta Ghosh, Steven C Almo, Vladislav V Verkhusha

Journal: J Mol Biol

PubMed ID: 34798132

Doi: 10.1016/j.jmb.2021.167359

Products & Services: Plasmid DNA Preparation

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

Authors: Felipe Melo-González, Jorge A Soto, Liliana A González, Jorge Fernández, Luisa F Duarte, Bárbara M Schultz, Nicolás M S Gálvez, Gaspar A Pacheco, Mariana Ríos, Yaneisi Vázquez, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Carolina Iturriaga, Omar P Vallejos, Roslye V Berríos-Rojas, Guillermo Hoppe-Elsholz, Marcela Urzúa, Nicole Bruneau, Rodrigo A Fasce, Judith Mora, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Gang Zeng, Weining Meng, José V González-Aramundiz, Pablo A González, Katia Abarca, Eugenio Ramírez, Alexis M Kalergis, Susan M Bueno

Journal: Front Immunol

PubMed ID: 34858404

Doi: 10.3389/fimmu.2021.747830

Products & Services: Recombinant Antibody Expression

Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies

Authors: Rashmi Patel, Siddharth Khare, Vinay S Mahajan

Journal: Clin Lab Med

PubMed ID: 35153048

Doi: 10.1016/j.cll.2021.10.007

A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and Display

Authors: Krista G Freeman, Katherine S Wetzel, Yu Zhang, Kira M Zack, Deborah Jacobs-Sera, Sara M Walters, Dominique J Barbeau, Anita K McElroy, John V Williams, Graham F Hatfull

Journal: Microorganisms

PubMed ID: 34946016

Doi: 10.3390/microorganisms9122414

Products & Services: Recombinant Antibody Expression

Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice

Authors: Hui-Tsu Lin, Cheng-Cheung Chen, Der-Jiang Chiao, Tein-Yao Chang, Xin-An Chen, Jenn-Jong Young, Szu-Cheng Kuo

Journal: Int J Biol Macromol

PubMed ID: 34774590

Doi: 10.1016/j.ijbiomac.2021.11.020

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Nanovaccines Mediated Subcutis-to-Intestine Cascade for Improved Protection against Intestinal Infections

Authors: Xiaofang Zhong, Guangsheng Du, Xuanyu Wang, Yangsen Ou, Hairui Wang, Yining Zhu, Xinyan Hao, Zhiqiang Xie, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun

Journal: Small

PubMed ID: 34825482

Doi: 10.1002/smll.202105530

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Baculovirus Vectors Induce the Production of Interferons in Swine: Their Potential in the Development of Antiviral Strategies

Authors: Guido Nicolás Molina, Sabrina Amalfi, Ignacio Otero, Oscar Taboga, María Paula Molinari

Journal: Vet Sci

PubMed ID: 34822651

Doi: 10.3390/vetsci8110278

Products & Services: Plasmid DNA Preparation

Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity

Authors: Debabrata Chowdhury, Jason C Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo, Julio A Landero Figueroa, Kavitha Subramanian Vignesh

Journal: Front Immunol

PubMed ID: 34867993

Doi: 10.3389/fimmu.2021.755961

Products & Services: Proteins, Expression, Isolation and Analysis

Long Non-Coding RNA Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development

Authors: Elpinickie Ninou, Artemis Michail, Panagiotis K Politis

Journal: Front Cell Dev Biol

PubMed ID: 34900989

Doi: 10.3389/fcell.2021.726857

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Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

Authors: Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya M Colpitts, Stephanie E Mohr, Yanhui Hu, Norbert Perrimon

Journal: Nat Commun

PubMed ID: 34819517

Doi: 10.1038/s41467-021-27129-3

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An Efficient Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Protein 9 Mutagenesis System for Oil Palm ()

Authors: Wan-Chin Yeap, Muhammad Rashdan Muad, David Ross Appleton

Journal: Front Plant Sci

PubMed ID: 34880893

Doi: 10.3389/fpls.2021.773656

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SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells

Authors: Dante Barreda, César Santiago, Juan R Rodríguez, José F Rodríguez, José M Casasnovas, Isabel Mérida, Antonia Ávila-Flores

Journal: Cells

PubMed ID: 34943787

Doi: 10.3390/cells10123279

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Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients

Authors: Belén G Sanchez, Jose M Gasalla, Manuel Sánchez-Chapado, Alicia Bort, Inés Diaz-Laviada

Journal: J Clin Med

PubMed ID: 34884175

Doi: 10.3390/jcm10235474

Products & Services: Mammalian Expression

Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region

Authors: Junping Hong, Dongmei Wei, Qian Wu, Ling Zhong, Kaiyun Chen, Yang Huang, Wanlin Zhang, Junyu Chen, Ningshao Xia, Xiao Zhang, Yixin Chen

Journal: Viruses

PubMed ID: 34960650

Doi: 10.3390/v13122380

Products & Services: Proteins, Expression, Isolation and Analysis

The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Authors: Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M Noordermeer, Toshiro K Ohsumi, Nicole Hustedt, Rachel K Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T F Young, Michael Zinda, Manuel Stucki, Daniel Durocher

Journal: Nat Cancer

PubMed ID: 35121901

Doi: 10.1038/s43018-021-00266-w

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

Authors: Chensu Wang, Ang Cui, Maurice Bukenya, Aereas Aung, Dikshant Pradhan, Charles A Whittaker, Yash Agarwal, Ayush Thomas, Simon Liang, Parastoo Amlashi, Heikyung Suh, Stefani Spranger, Nir Hacohen, Darrell J Irvine

Journal: Cell Rep

PubMed ID: 34818534

Doi: 10.1016/j.celrep.2021.110021

Products & Services: Peptide Synthesis

Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

Authors: In-Chi Young, Bogang Wu, Jaclyn Andricovich, Sung-Ting Chuang, Rong Li, Alexandros Tzatsos, Ray-Chang Wu, Mei-Yi Wu

Journal: Cell Rep

PubMed ID: 34818550

Doi: 10.1016/j.celrep.2021.110036

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Assessment of in vitro activities of novel modified antimicrobial peptides against clarithromycin resistant Mycobacterium abscessus

Authors: Phantitra Sudadech, Sittiruk Roytrakul, Orawee Kaewprasert, Auttawit Sirichoat, Ploenchan Chetchotisakd, Sakawrat Kanthawong, Kiatichai Faksri

Journal: PLoS ONE

PubMed ID: 34780520

Doi: 10.1371/journal.pone.0260003

Products & Services: Peptide Synthesis

A molecular dynamics-guided mutagenesis identifies two aspartic acid residues involved in the pH-dependent activity of OG-OXIDASE 1

Authors: Anna Scortica, Matteo Capone, Daniele Narzi, Mario Frezzini, Valentina Scafati, Moira Giovannoni, Francesco Angelucci, Leonardo Guidoni, Benedetta Mattei, Manuel Benedetti

Journal: Plant Physiol Biochem

PubMed ID: 34800821

Doi: 10.1016/j.plaphy.2021.11.011

Products & Services: Gene Synthesis

Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection

Authors: Henry Daniell, Smruti K Nair, Nardana Esmaeili, Geetanjali Wakade, Naila Shahid, Prem Kumar Ganesan, Md Reyazul Islam, Ariel Shepley-McTaggart, Sheng Feng, Ebony N Gary, Ali R Ali, Manunya Nuth, Selene Nunez Cruz, Jevon Graham-Wooten, Stephen J Streatfield, Ruben Montoya-Lopez, Paul Kaznica, Margaret Mawson, Brian J Green, Robert Ricciardi, Michael Milone, Ronald N Harty, Ping Wang, David B Weiner, Kenneth B Margulies, Ronald G Collman

Journal: Mol Ther

PubMed ID: 34774754

Doi: 10.1016/j.ymthe.2021.11.008

Products & Services: Plasmid DNA Preparation

The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway

Authors: Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang

Journal: Bioengineered

PubMed ID: 34783297

Doi: 10.1080/21655979.2021.2005932

Products & Services: Plasmid DNA Preparation

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Authors: Ehab Al-Moubarak, Holly A Shiels, Yihong Zhang, Chunyun Du, Oliver Hanington, Stephen C Harmer, Christopher E Dempsey, Jules C Hancox

Journal: Cell Mol Life Sci

PubMed ID: 34727194

Doi: 10.1007/s00018-021-03967-8

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The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain

Authors: María Rodríguez-Muñoz, Elsa Cortés-Montero, Yara Onetti, Pilar Sánchez-Blázquez, Javier Garzón-Niño

Journal: Biomolecules

PubMed ID: 34827679

Doi: 10.3390/biom11111681

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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Authors: Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L Udaskin, Ahmet Mentes, Richard Huang, Betty P K Poon, Wenguang He, Ivette Valencia-Sama, Claire M Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S Irwin, Jeffrey E Lee, Ming-Sound Tsao, Brian Raught, Christopher B Marshall, Michael Ohh, Mitsuhiko Ikura

Journal: Nat Commun

PubMed ID: 34725361

Doi: 10.1038/s41467-021-26526-y

Products & Services: Bacterial Expression

Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells

Authors: Yuanyuan Shi, Jian Chen, Wei-Jie Zeng, Miao Li, Wenxue Zhao, Xing-Ding Zhang, Jie Yao

Journal: BMC Biol

PubMed ID: 34789250

Doi: 10.1186/s12915-021-01178-y

Products & Services: Gene Synthesis

Tasquinimod efficacy and S100A9 expression in glucose-treated HREC cells

Authors: Ji Jin, Ji Zhang, Shuyang Bu

Journal: Int Ophthalmol

PubMed ID: 34796432

Doi: 10.1007/s10792-021-02038-y

Products & Services: Gene Synthesis

DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation

Authors: Ronghui Lou, Weizhen Liu, Rongjie Li, Shanshan Li, Xuming He, Wenqing Shui

Journal: Nat Commun

PubMed ID: 34795227

Doi: 10.1038/s41467-021-26979-1

Products & Services: Peptide Synthesis

ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments

Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal

Journal: Molecules

Doi: 10.3390/molecules26237155

Products & Services: Gene Synthesis

A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library

Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun

Journal: Front Oncol.

PubMed ID: 34912719

Doi: doi.org/10.3389/fonc.2021.781046

Products & Services: Recombinant Proteins

SARS-CoV-2 exposure in wild white-tailed deer ()

Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34732584

Doi: 10.1073/pnas.2114828118

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Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Authors: Mohamed S Abdel-Hakeem, Sasikanth Manne, Jean-Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L Johnson, Josephine R Giles, Divij Mathew, Allison R Greenplate, Golnaz Vahedi, E John Wherry

Journal: Nat Immunol

PubMed ID: 34588688

Doi: 10.1038/s41590-021-01057-2

Products & Services: Recombinant Proteins

Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China

Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan

Journal: Innovation (N Y)

PubMed ID: 34746904

Doi: 10.1016/j.xinn.2021.100181

Products & Services: Proteins, Expression, Isolation and Analysis

Heterologous Expression of a Thermostable Chitinase from and Its Application for High Yield Production of Glucosamine from Shrimp Shell

Authors: Yongmei Lyu, Feng Zheng, Chuanxing Qiu, Meng Wang, Dujun Wang, Xiaoyang Zhang, Josef Voglmeir, Li Liu, Xiaohong Yu

Journal: Foods

PubMed ID: 34829089

Doi: 10.3390/foods10112808

Products & Services: Proteins, Expression, Isolation and Analysis

Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Authors: Sun Hee Moon, Yihong Kaufmann, Ryoichi Fujiwara, En Huang

Journal: BMC Microbiol

PubMed ID: 34819026

Doi: 10.1186/s12866-021-02383-z

Products & Services: Proteins, Expression, Isolation and Analysis

Surface-Functionalized Silica-Coated Calcium Phosphate Nanoparticles Efficiently Deliver DNA-Based HIV-1 Trimeric Envelope Vaccines against HIV-1

Authors: Shuang Li, Bo Wang, Shun Jiang, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: ACS Appl Mater Interfaces

PubMed ID: 34735127

Doi: 10.1021/acsami.1c16989

Products & Services: Plasmid DNA Preparation

LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3

Authors: Jing Li, Xiaojie Quan, Saifei Lei, Gang Chen, Jiawei Hong, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang

Journal: Environ Pollut

PubMed ID: 34801623

Doi: 10.1016/j.envpol.2021.118542

Products & Services: Plasmid DNA Preparation

Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine suicide system for canine melanoma

Authors: Gerardo C Glikin, Jesica B Allende, Liliana M E Finocchiaro

Journal: Vet Comp Oncol

PubMed ID: 34724324

Doi: 10.1111/vco.12780

Products & Services: PCR Cloning and Subcloning

Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit

Authors: Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere, Lennart Martens, Sven Degroeve, Wim De Neve, Wim Vranken, Nico Callewaert

Journal: Nat Commun

PubMed ID: 34741024

Doi: 10.1038/s41467-021-26720-y

Products & Services: PCR Cloning and Subcloning

The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function

Authors: Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T Burgess, Mark N Adams, Kenneth J O'Byrne, Derek J Richard, Neha S Gandhi, Emma Bolderson

Journal: Front Cell Dev Biol

PubMed ID: 34820387

Doi: 10.3389/fcell.2021.775441

Products & Services: PCR Cloning and Subcloning

Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system

Authors: Federico Camicia, Hugo R Vaca, Sang-Kyu Park, Augusto E Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M Celentano, Jonathan S Marchant, Mara C Rosenzvit

Journal: PLoS ONE

PubMed ID: 34762657

Doi: 10.1371/journal.pone.0259104

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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel-Hagen, Christopher S Seet, Gay M Crooks, Sarah M Larson, Joshua P Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B Kohn, Owen Witte, Pin Wang, Lili Yang

Journal: Cell Rep Med

PubMed ID: 34841295

Doi: 10.1016/j.xcrm.2021.100449

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G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D receptor desensitization

Authors: Richard Ågren, Kristoffer Sahlholm

Journal: FASEB J

PubMed ID: 34699610

Doi: 10.1096/fj.202100704RR

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MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3

Authors: Xiaochen Hu, Hongjun Miao

Journal: Mol Biol Rep

PubMed ID: 34757596

Doi: 10.1007/s11033-021-06849-1

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Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances

Authors: Madison M Mann, James D Tang, Bryan W Berger

Journal: Biotechnol Bioeng

PubMed ID: 34723386

Doi: 10.1002/bit.27981

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Authors: Jasmine George, Yongsheng Li, Ishaque P Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S Rader, Anil K Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan

Journal: Cell Rep

PubMed ID: 34731628

Doi: 10.1016/j.celrep.2021.109934

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G3BP1 inhibits Cul3 to amplify AR signaling and promote prostate cancer

Authors: Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian D Robinson, Arul M Chinnaiyan, Mark A Rubin, Christopher E Barbieri, Pengbo Zhou

Journal: Nat Commun

PubMed ID: 34795264

Doi: 10.1038/s41467-021-27024-x

The B-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine

Authors: William G Walls, James D Moody, Elizabeth C McDaniel, Maria Villanueva, Eric M Shepard, William E Broderick, Joan B Broderick

Journal: J Inorg Biochem

PubMed ID: 34847521

Doi: 10.1016/j.jinorgbio.2021.111662

Products & Services: Codon Optimization

Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation

Authors: Marek Jindra, William J McKinstry, Thomas Nebl, Lenka Bittova, Bin Ren, Jan Shaw, Tram Phan, Louis Lu, Jason K K Low, Joel P Mackay, Lindsay G Sparrow, George O Lovrecz, Ronald J Hill

Journal: J Biol Chem

PubMed ID: 34758356

Doi: 10.1016/j.jbc.2021.101387

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New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products

Authors: Julia K Lewis, Andrew S Jochimsen, Sarah J Lefave, Anthony P Young, William M Kincannon, Andrew G Roberts, Matthew T Kieber-Emmons, Vahe Bandarian

Journal: Biochemistry

PubMed ID: 34730336

Doi: 10.1021/acs.biochem.1c00469

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In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum

Authors: Luis Ariel Espinosa, Yassel Ramos, Ivan Andújar, Enso Onill Torres, Gleysin Cabrera, Alejandro Martín, Diamilé Roche, Glay Chinea, Mónica Becquet, Isabel González, Camila Canaán-Haden, Elías Nelson, Gertrudis Rojas, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Tamy Boggiano, Julio Palacio, Sum Lai Lozada Chang, Lourdes Hernández, Kathya Rashida de la Luz Hernández, Saloheimo Markku, Marika Vitikainen, Yury Valdés-Balbín, Darielys Santana-Medero, Daniel G Rivera, Vicente Vérez-Bencomo, Mark Emalfarb, Ronen Tchelet, Gerardo Guillén, Miladys Limonta, Eulogio Pimentel, Marta Ayala, Vladimir Besada, Luis Javier González

Journal: Anal Bioanal Chem

PubMed ID: 34739558

Doi: 10.1007/s00216-021-03721-w

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Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

Authors: Bassel Akache, Tyler M Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A Harrison, Diana Duque, Julie Haukenfrers, Martin A Rossotti, Francis Gaudreault, Usha D Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J McCluskie

Journal: Sci Rep

PubMed ID: 34750472

Doi: 10.1038/s41598-021-01363-7

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Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations

Authors: Barbora Novotná, Lucie Holá, Monika Staś, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zdeněk Vavřina, Miloš Buděšínský, Radek Liboska, Florian Chevrier, Juraj Dobiaš, Evzen Boura, Lubomír Rulíšek, Gabriel Birkuš

Journal: Biochemistry

PubMed ID: 34788017

Doi: 10.1021/acs.biochem.1c00692

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Two C1-oxidizing AA9 lytic polysaccharide monooxygenases from Sordaria brevicollis differ in thermostability, activity, and synergy with cellulase

Authors: Xi Zhang, Kaixiang Chen, Liangkun Long, Shaojun Ding

Journal: Appl Microbiol Biotechnol

PubMed ID: 34748039

Doi: 10.1007/s00253-021-11677-1

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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Authors: Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S Toor, Sarvind Tripathi, Son Nguyen, Helena Shen, Tiffany Noel, Nicole L Church, Amber Weiner, Nathan Kendsersky, Dan Martinez, Rebecca Weisberg, Molly Christie, Laurence Eisenlohr, Kristopher R Bosse, Dimiter S Dimitrov, Stefan Stevanovic, Nikolaos G Sgourakis, Ben R Kiefel, John M Maris

Journal: Nature

PubMed ID: 34732890

Doi: 10.1038/s41586-021-04061-6

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Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate and Staphylococcal Skin Infection

Authors: Sirikwan Sangboonruang, Natthawat Semakul, Mohammad A Obeid, Marta Ruano, Kuntida Kitidee, Usanee Anukool, Kidsadagon Pringproa, Panuwan Chantawannakul, Valerie A Ferro, Yingmanee Tragoolpua, Khajornsak Tragoolpua

Journal: Int J Nanomedicine

PubMed ID: 34819727

Doi: 10.2147/IJN.S325901

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Multifunctional Dendronized Polypeptides for Controlled Adjuvanticity

Authors: Zhiyuan Fan, Sharon Jan, James C Hickey, D Huw Davies, Jiin Felgner, Philip L Felgner, Zhibin Guan

Journal: Biomacromolecules

PubMed ID: 34788023

Doi: 10.1021/acs.biomac.1c01052

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Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Authors: Hojae Lee, Jae Jin Lee, Na Young Park, Sandeep Kumar Dubey, Taeyong Kim, Kai Ruan, Su Bin Lim, Seong-Hyun Park, Shinwon Ha, Irina Kovlyagina, Kyung-Tai Kim, Seongjun Kim, Yohan Oh, Hyesoo Kim, Sung-Ung Kang, Mi-Ryoung Song, Thomas E Lloyd, Nicholas J Maragakis, Young Bin Hong, Hyungjin Eoh, Gabsang Lee

Journal: Nat Neurosci

PubMed ID: 34782793

Doi: 10.1038/s41593-021-00944-z

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SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

Authors: Kisoo Pahk, Sang Gil Lee, Chanmin Joung, Eun-Ok Kim, Hyun Woo Kwon, Dong Hwi Kim, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim

Journal: Biomed Pharmacother

PubMed ID: 34813997

Doi: 10.1016/j.biopha.2021.112441

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Insights into ROS-dependent signalling underlying transcriptomic plant responses to the herbicide 2,4-D

Authors: María C Romero-Puertas, M Ángeles Peláez-Vico, Diana M Pazmiño, María Rodríguez-Serrano, Laura Terrón-Camero, Rocío Bautista, Aurelio Gómez-Cadenas, M Gonzalo Claros, José León, Luisa M Sandalio

Journal: Plant Cell Environ

PubMed ID: 34800292

Doi: 10.1111/pce.14229

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The effects of Omarigliptin on promoting osteoblastic differentiation

Authors: Fake Liao, Xiunian Hu, Rijiang Chen

Journal: Bioengineered

PubMed ID: 34787070

Doi: 10.1080/21655979.2021.1999366

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An oral vaccine based on chitosan/aluminum adjuvant induces both local and systemic immune responses in turbot (Scophthalmus maximus)

Authors: Peng Jin, Fei Sun, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiaohong Liu

Journal: Vaccine

PubMed ID: 34844823

Doi: 10.1016/j.vaccine.2021.10.063

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Production, purification and characterization of a double-tagged TEV protease

Authors: Joaquín Dalla Rizza, Claudia Ortega, Federico Carrión, Martín Fló, Agustín Correa

Journal: Protein Expr Purif

PubMed ID: 34798273

Doi: 10.1016/j.pep.2021.106021

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Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARS

Authors: Lili Zhao, Na Han, Yali Zheng, Huiying Rao, Jia Li, Yanwen Chen, Bing Yu, Yu Xu, Hongsong Chen, Zhancheng Gao, Baoguo Jiang

Journal: Front Cell Infect Microbiol

PubMed ID: 34869070

Doi: 10.3389/fcimb.2021.768993

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A binary effector module secreted by a type VI secretion system

Authors: Yasmin Dar, Biswanath Jana, Eran Bosis, Dor Salomon

Journal: EMBO Rep

PubMed ID: 34752000

Doi: 10.15252/embr.202153981

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High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein

Authors: Ching-Ting Wang, Tetsushi Tezuka, Naoki Takeda, Kimi Araki, Satoko Arai, Toru Miyazaki

Journal: PLoS ONE

PubMed ID: 34843572

Doi: 10.1371/journal.pone.0260449

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Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

Authors: Christian Tüting, Fotis L Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian, Panagiotis L Kastritis

Journal: Nat Commun

PubMed ID: 34836937

Doi: 10.1038/s41467-021-27287-4

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A Novel Serum tsRNA for Diagnosis and Prediction of Nephritis in SLE

Authors: Ping Yang, Xiaoshan Zhang, Shanshan Chen, Yue Tao, Mingzhe Ning, Yijia Zhu, Jun Liang, Wei Kong, Bo Shi, Zhiyang Li, Han Shen, Yanbo Wang

Journal: Front Immunol

PubMed ID: 34867955

Doi: 10.3389/fimmu.2021.735105

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A novel chimeric protein with enhanced cytotoxic effects on breast cancer in vitro and in vivo

Authors: Fereshte Hazrati, Massoud Saidijam, Yaghoub Ahmadyousefi, Fatemeh Nouri, Hamidreza Ghadimipour, Mohammadreza Moradi, Rasool Haddadi, Meysam Soleimani

Journal: Proteins

PubMed ID: 34812523

Doi: 10.1002/prot.26285

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Diagnostic Performance of Self-Collected Saliva Versus Nasopharyngeal Swab for the Molecular Detection of SARS-CoV-2 in the Clinical Setting

Authors: Mohammad Khaja Mafij Uddin, Tahmina Shirin, Mohammad Enayet Hossain, Ahmed Nawsher Alam, Jenifar Quaiyum Ami, Rashedul Hasan, Mojnu Miah, Nusrat Jahan Shaly, Shahriar Ahmed, S M Mazidur Rahman, Mustafizur Rahman, Sayera Banu

Journal: Microbiol Spectr

PubMed ID: 34730436

Doi: 10.1128/Spectrum.00468-21

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Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species

Authors: Xinchen Jiang, Junliang Yin, Lixin Wang, Keyong Xi, Xiongmeng Zhu, Gang Li, Yongxing Zhu, Yiqing Liu

Journal: Plant Genome

PubMed ID: 34741493

Doi: 10.1002/tpg2.20167

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Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

Authors: Andrea Moreno, Victor Taleb, María Sebastián, Ernesto Anoz-Carbonell, Marta Martínez-Júlvez, Milagros Medina

Journal: IUBMB Life

PubMed ID: 34813144

Doi: 10.1002/iub.2576

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Authors: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

Journal: Cell Stem Cell

PubMed ID: 34856120

Doi: 10.1016/j.stem.2021.11.003

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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang

Journal: Cancer Cell Int

PubMed ID: 34844614

Doi: 10.1186/s12935-021-02351-7

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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv oryzae

Authors: Yuejing Gui, Dongsheng Tian, Kar Hui Ong, Joanne Chin Yi Teo, Zhongchao Yin

Journal: Transgenic Res

PubMed ID: 34748132

Doi: 10.1007/s11248-021-00290-7

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A super PPR cluster for restoring fertility revealed by genetic mapping, homocap-seq and de novo assembly in cotton

Authors: Bin Gao, Gaofeng Ren, Tianwang Wen, Haiping Li, Xianlong Zhang, Zhongxu Lin

Journal: Theor Appl Genet

PubMed ID: 34811574

Doi: 10.1007/s00122-021-03990-0

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An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Authors: Anja Ziegler, Judith Olzhausen, Eman Hamza, Ana Stojiljkovic, Michael H Stoffel, Mattia Garbani, Claudio Rhyner, Eliane Marti

Journal: Vet Immunol Immunopathol

PubMed ID: 34800874

Doi: 10.1016/j.vetimm.2021.110351

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Positively Regulates Pepper Immunity by Targeting against Inoculation through Modulating Defense-Related Genes

Authors: Ansar Hussain, Muhammad Ifnan Khan, Mohammed Albaqami, Shahzadi Mahpara, Ijaz Rasool Noorka, Mohamed A A Ahmed, Bandar S Aljuaid, Ahmed M El-Shehawi, Zhiqin Liu, Shahid Farooq, Ali Tan Kee Zuan

Journal: Int J Mol Sci

PubMed ID: 34769521

Doi: 10.3390/ijms222112091

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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Authors: Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy

Journal: Microorganisms

PubMed ID: 34835449

Doi: 10.3390/microorganisms9112323

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The pleiotropic functions of intracellular hydrophobins in aerial hyphae and fungal spores

Authors: Feng Cai, Zheng Zhao, Renwei Gao, Peijie Chen, Mingyue Ding, Siqi Jiang, Zhifei Fu, Pingyong Xu, Komal Chenthamara, Qirong Shen, Günseli Bayram Akcapinar, Irina S Druzhinina

Journal: PLoS Genet

PubMed ID: 34788288

Doi: 10.1371/journal.pgen.1009924

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A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum

Authors: Tarkeshwar Kumar, Satarupa Maitra, Abdur Rahman, Souvik Bhattacharjee

Journal: PLoS Pathog

PubMed ID: 34780541

Doi: 10.1371/journal.ppat.1009595

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The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development

Authors: Hidenori Ito, Rika Morishita, Mariko Noda, Tomoki Ishiguro, Masashi Nishikawa, Koh-Ichi Nagata

Journal: J Biol Chem

PubMed ID: 34800437

Doi: 10.1016/j.jbc.2021.101427

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Microinjection of pruritogens in NGF-sensitized human skin

Authors: Hans Jürgen Solinski, Roman Rukwied, Martin Schmelz

Journal: Sci Rep

PubMed ID: 34728705

Doi: 10.1038/s41598-021-00935-x

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A feminizing switch in a hemimetabolous insect

Authors: Ji-Chong Zhuo , Hou-Hong Zhang , Qing-Ling Hu , Jin-Li Zhang , Jia-Bao Lu , Han-Jing Li , Yu-Cheng Xie , Wei-Wei Wang , Yan Zhang , Hai-Qiang Wang , Hai-Jian Huang , Gang Lu , Jian-Ping Chen , Jun-Min Li , Zhi-Jian Tu , Chuan-Xi Zhang

Journal: Sci Adv

PubMed ID: 34826246

Doi: 10.1126/sciadv.abf9237

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A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity

Authors: Wanying Zhang, Haiyang Li, Limin Wang, Shunpei Xie, Yuan Zhang, Ruijiao Kang, Mengjuan Zhang, Panpan Zhang, Yonghui Li, Yanfeng Hu, Min Wang, Linlin Chen, Hongxia Yuan, Shengli Ding, Honglian Li

Journal: Mol Plant Pathol

PubMed ID: 34741560

Doi: 10.1111/mpp.13155

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DNA Matrix Operation Based on the Mechanism of the DNAzyme Binding to Auxiliary Strands to Cleave the Substrate

Authors: Shaoxia Xu, Yuan Liu, Shihua Zhou, Qiang Zhang, Nikola K Kasabov

Journal: Biomolecules

PubMed ID: 34944442

Doi: 10.3390/biom11121797

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Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition

Authors: Adele Vanacore, Giuseppe Vitiello, Alan Wanke, Domenico Cavasso, Luke A Clifton, Lisa Mahdi, María Asunción Campanero-Rhodes, Dolores Solís, Manfred Wuhrer, Simone Nicolardi, Antonio Molinaro, Roberta Marchetti, Alga Zuccaro, Luigi Paduano, Alba Silipo

Journal: Carbohydr Polym

PubMed ID: 34893256

Doi: 10.1016/j.carbpol.2021.118839

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Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Authors: Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Jukka Kervinen, Lars Hellman

Journal: Int J Mol Sci

PubMed ID: 34884431

Doi: 10.3390/ijms222312627

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Patterns of Tetracapsuloides bryosalmonae infection of three salmonid species in large, deep Norwegian lakes

Authors: Tone Jøran Oredalen, Mona Saebø, Tor Atle Mo

Journal: J Fish Dis

PubMed ID: 34747501

Doi: 10.1111/jfd.13548

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Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

Authors: Tianchuan Zhu, Yuchen Xiao, Xiaojun Meng, Lantian Tang, Bin Li, Zhaoyan Zhao, Qingqin Tan, Hong Shan, Lei Liu, Xi Huang

Journal: J Nanobiotechnology

PubMed ID: 34823562

Doi: 10.1186/s12951-021-01148-0

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The Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation

Authors: Nina Gillis-Germitsch, Tobias Kockmann, Lars M Asmis, Lucienne Tritten, Manuela Schnyder

Journal: Front Cell Infect Microbiol

PubMed ID: 34796127

Doi: 10.3389/fcimb.2021.753320

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Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

Authors: Benjamin J Evert, Shuxiong Chen, Robyn McConville, Ryan W J Steel, Julie Healer, Justin A Boddey, Lucas Huntimer, Bernd H A Rehm

Journal: npj Vaccines

PubMed ID: 34845267

Doi: 10.1038/s41541-021-00408-2

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Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation

Authors: Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Michele Vendruscolo, Sara Linse

Journal: ACS Chem Neurosci

PubMed ID: 34783519

Doi: 10.1021/acschemneuro.1c00454

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High-throughput and high-dimensional single-cell analysis of antigen-specific CD8 T cells

Authors: Ke-Yue Ma, Alexandra A Schonnesen, Chenfeng He, Amanda Y Xia, Eric Sun, Eunise Chen, Katherine R Sebastian, Yu-Wan Guo, Robert Balderas, Mrinalini Kulkarni-Date, Ning Jiang

Journal: Nat Immunol

PubMed ID: 34811538

Doi: 10.1038/s41590-021-01073-2

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Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV

Authors: Ros Chapman, Michiel van Diepen, Nicola Douglass, Shireen Galant, Mohamed Jaffer, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny L Moore, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34835214

Doi: 10.3390/vaccines9111281

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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Authors: Daniel T Johnson, Jiarong Zhou, Ashley V Kroll, Ronnie H Fang, Ming Yan, Crystal Xiao, Xiufen Chen, Justin Kline, Liangfang Zhang, Dong-Er Zhang

Journal: Leukemia

PubMed ID: 34845316

Doi: 10.1038/s41375-021-01432-w

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Scaling DNA data storage with nanoscale electrode wells

Authors: Bichlien H Nguyen, Christopher N Takahashi, Gagan Gupta, Jake A Smith, Richard Rouse, Paul Berndt, Sergey Yekhanin, David P Ward, Siena D Ang, Patrick Garvan, Hsing-Yeh Parker, Rob Carlson, Douglas Carmean, Luis Ceze, Karin Strauss

Journal: Sci Adv

PubMed ID: 34818035

Doi: 10.1126/sciadv.abi6714

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Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

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Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

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Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

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