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Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus

Authors: Alexandra Vaisman, John P McDonald, Mallory R Smith, Sender L Aspelund, Thomas C Evans, Roger Woodgate

Journal: Front Mol Biosci

PubMed ID: 34805283

Doi: 10.3389/fmolb.2021.778400

Products & Services: Codon Optimization

Evaluation of Cellular Immunity with ASFV Infection by Swine Leukocyte Antigen (SLA)-Peptide Tetramers

Authors: Wenqiang Sun, He Zhang, Wenhui Fan, Lihong He, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Rongliang Hu, Tingrong Luo, Wenjun Liu, Jing Li

Journal: Viruses

PubMed ID: 34835070

Doi: 10.3390/v13112264

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Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen

Authors: Andrey M Grishin, Nataliya V Dolgova, Shelby Landreth, Olivier Fisette, Ingrid J Pickering, Graham N George, Darryl Falzarano, Miroslaw Cygler

Journal: J Mol Biol

PubMed ID: 34780781

Doi: 10.1016/j.jmb.2021.167357

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Structure of procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

Authors: Edem Gavor, Yeu Khai Choong, Nikhil Kumar Tulsian, Digant Nayak, Fakhriedzwan Idris, Hariharan Sivaraman, Donald Heng Rong Ting, Alonso Sylvie, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Life Sci Alliance

PubMed ID: 34750241

Doi: 10.26508/lsa.202101211

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Tyrosinase-based production of L-DOPA by Corynebacterium glutamicum

Authors: Eldin Kurpejović, Volker F Wendisch, Berna Sariyar Akbulut

Journal: Appl Microbiol Biotechnol

PubMed ID: 34762142

Doi: 10.1007/s00253-021-11681-5

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Overexpression of the rice BAHD acyltransferase AT10 increases xylan-bound p-coumarate and reduces lignin in Sorghum bicolor

Authors: Yang Tian, Chien-Yuan Lin, Joon-Hyun Park, Chuan-Yin Wu, Ramu Kakumanu, Venkataramana R Pidatala, Khanh M Vuu, Alberto Rodriguez, Patrick M Shih, Edward E K Baidoo, Stephen Temple, Blake A Simmons, John M Gladden, Henrik V Scheller, Aymerick Eudes

Journal: Biotechnol Biofuels

PubMed ID: 34801067

Doi: 10.1186/s13068-021-02068-9

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A novel DNA platform designed for vaccine use with high transgene expression and immunogenicity

Authors: George Giorgi Babuadze, Jose Echanove, Claude Lamarre, Marc-Antoine deLaVega, Hugues Fausther-Bovendo, Trina Racine, Alejandro M Gomez, Hiva Azizi, Mathew Wade, Robert Kozak, Gary P Kobinger

Journal: Vaccine

PubMed ID: 34774358

Doi: 10.1016/j.vaccine.2021.10.008

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Insulin-activated store-operated Ca entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Authors: Ji-Hee Kim, Kyu-Hee Hwang, Bao T N Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, Seung-Kuy Cha

Journal: Nat Commun

PubMed ID: 34764278

Doi: 10.1038/s41467-021-26900-w

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Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells

Authors: Shuya Kyu, Richard P Ramonell, Merin Kuruvilla, Colleen S Kraft, Yun F Wang, Ann R Falsey, Edward E Walsh, John L Daiss, Simon Paulos, Gowrisankar Rajam, Hao Wu, Srinivasan Velusamy, F Eun-Hyung Lee

Journal: PLoS ONE

PubMed ID: 34767590

Doi: 10.1371/journal.pone.0259644

Products & Services: Bacterial Expression

Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Authors: Jinhye Ryu, Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 34826501

Doi: 10.1016/j.dci.2021.104324

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New and efficient purification process for recombinant human insulin produced in Escherichia coli

Authors: Yin Yin Siew, Amrita Rai, Han Bin Pek, Dave Siak-Wei Ow, Wei Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 34821966

Doi: 10.1007/s00253-021-11697-x

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Improved the Activity of Phosphite Dehydrogenase and its Application in Plant Biotechnology

Authors: Tongtong Liu, Lili Yuan, Suren Deng, Xiangxian Zhang, Hongmei Cai, Guangda Ding, Fangsen Xu, Lei Shi, Gaobing Wu, Chuang Wang

Journal: Front Bioeng Biotechnol

PubMed ID: 34900961

Doi: 10.3389/fbioe.2021.764188

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Recombinant Bacillus subtilis flagellin Hag is a potent immunostimulant with reduced proinflammatory properties compared to Salmonella enterica serovar Typhimurium FljB

Authors: Mélanie Côté-Cyr, Laurie Gauthier, Ximena Zottig, Steve Bourgault, Denis Archambault

Journal: Vaccine

PubMed ID: 34844822

Doi: 10.1016/j.vaccine.2021.11.049

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Enhancing the resilience of transgenic cotton for insect resistance

Authors: Mohsin Shad, Aneela Yasmeen, Saira Azam, Allah Bakhsh, Ayesha Latif, Naila Shahid, Sahar Sadaqat, Abdul Qayyum Rao, Ahmad Ali Shahid

Journal: Mol Biol Rep

PubMed ID: 34839448

Doi: 10.1007/s11033-021-06972-z

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of SGLT1 alleviates the glycemic variability-induced cardiac fibrosisvia inhibiting activations of macrophage and cardiac fibroblast

Authors: Weihua Wu, Qian Chai, Ziying Zhang

Journal: MOL CELL BIOL

PubMed ID: 34842443

Doi: 10.1128/MCB.00282-21

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Genetic manipulation of trehalose-6-phosphate synthase results in changes in the soluble sugar profile in transgenic sugarcane stems

Authors: Casey Gabriel, Jean-Jacque Fernhout, Franziska Fichtner, Regina Feil, John E Lunn, Jens Kossmann, James R Lloyd, Christell van der Vyver

Journal: Plant Direct

PubMed ID: 34765864

Doi: 10.1002/pld3.358

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MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs

Authors: Kien Lam Ung, Husam Alsarraf, Laurent Kremer, Mickaël Blaise

Journal: Protein Expr Purif

PubMed ID: 34767949

Doi: 10.1016/j.pep.2021.106014

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A SYBR Green-based real-time RT-PCR assay to differentiate the H1N1 influenza virus lineages

Authors: Yulin Cong, Yixue Sun, Xiaoyu Deng, Haiying Yu, Xiaohuan Lian, Yanlong Cong

Journal: J Virol Methods

PubMed ID: 34848281

Doi: 10.1016/j.jviromet.2021.114387

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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis

Authors: Charles J Cho, Dongkook Park, Jason C Mills

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34816763

Doi: 10.1152/ajpgi.00246.2021

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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang, Hongyi Zhang

Journal: Cell Mol Biol Lett

PubMed ID: 34837962

Doi: 10.1186/s11658-021-00295-4

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Structure and activation mechanism of the hexameric plasma membrane H+-ATPase

Authors: Peng Zhao, Chaoran Zhao, Dandan Chen, Caihong Yun, Huilin Li, Lin Bai

Journal: Nat Commun.

PubMed ID: 34750373

Doi: 10.1038/s41467-021-26782-y

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient DNA interrogation of SpCas9 governed by its electrostatic interaction with DNA beyond the PAM and protospacer

Authors: Qian Zhang, Ziting Chen, Fangzhu Wang, Siqi Zhang, Hongyu Chen, Xueying Gu, Fengcai Wen, Jiachuan Jin, Xia Zhang, Xingxu Huang

Journal: Nucleic Acids Research

Doi: 10.1093/nar/gkab1139

Products & Services: Proteins, Expression, Isolation and Analysis

RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association

Authors: Valérie C Cabana, Antoine Y Bouchard, Audrey M Sénécal, Kim Ghilarducci, Saïd Kourrich, Laurent Cappadocia, Marc P Lussier

Journal: Cells

PubMed ID: 34831286

Doi: 10.3390/cells10113063 Free PMC article

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Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin

Authors: Maria Petrosino, Francesco Stellato, Roberta Chiaraluce, Valerio Consalvi, Giovanni La Penna, Alessandra Pasquo, Olivier Proux, Giancarlo Rossi, Silvia Morante

Journal: ChemistryOpen

PubMed ID: 34791819

Doi: 10.1002/open.202100217

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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication

Authors: Sai Wang, Kitti Wing Ki Chan, Min Jie Alvin Tan, Charlotte Flory, Dahai Luo, Julian Lescar, Jade K Forwood, Subhash G Vasudevan

Journal: RNA

PubMed ID: 34759006

Doi: 10.1261/rna.078949.121

Products & Services: Mammalian Expression

H, N and C resonance assignments of the Q61H mutant of human KRAS bound to GDP

Authors: Qiwei Huang, Elizabeth Yihui Ng, Qingxin Li, CongBao Kang

Journal: Biomol NMR Assign

PubMed ID: 34787842

Doi: 10.1007/s12104-021-10058-z

Products & Services: Mammalian Expression

Inducing I and phase 1 repolarization of the cardiac action potential with a Kv43/KChIP21 bicistronic transgene

Authors: Nan Wang, Eef Dries, Ewan D Fowler, Stephen C Harmer, Jules C Hancox, Mark B Cannell

Journal: J Mol Cell Cardiol

PubMed ID: 34823101

Doi: 10.1016/j.yjmcc.2021.11.004

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Mediates Hormonally Regulated Dominance Rank in a Social Bee

Authors: Atul Pandey, Guy Bloch

Journal: Biology (Basel)

PubMed ID: 34827180

Doi: 10.3390/biology10111188

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee, Chae Rim Lee, Da-Som Kim, Yang-Mi Her, Jeong Won Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

Journal: Cell Mol Immunol

PubMed ID: 34782759

Doi: 10.1038/s41423-021-00798-2

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High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study

Authors: Andres Moreira-Soto, Johanna Maribel Pachamora Diaz, Lilian González-Auza, Xiomara Jeanleny Merino Merino, Alvaro Schwalb, Christian Drosten, Eduardo Gotuzzo, Michael Talledo, Heriberto Arévalo Ramirez, Roxana Peralta Delgado, Spassky Bocanegra Vargas, Jan Felix Drexler

Journal: mSphere

PubMed ID: 34817236

Doi: 10.1128/mSphere.00685-21

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The multicellular signalling network of ovarian cancer metastases

Authors: Leah Sommerfeld, Florian Finkernagel, Julia M Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Anna M Sokol, Johannes Graumann, Silke Reinartz, Rolf Müller

Journal: Clin Transl Med

PubMed ID: 34841720

Doi: 10.1002/ctm2.633

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A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins

Authors: Gang Liu, Dong-Yun Zuo, Peng Yang, Wei-Jie He, Zheng Yang, Jing-Bo Zhang, Ai-Bo Wu, Shu-Yuan Yi, He-Ping Li, Tao Huang, Yu-Cai Liao

Journal: J Fungi (Basel)

PubMed ID: 34829228

Doi: 10.3390/jof7110941

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Influence of flagellin polymorphisms, gene regulation, and responsive memory on the motility of species that cause bacterial spot disease of solanaceous plants

Authors: Maria Laura Malvino, Amie Joy Bott, Cory Edwin Green, Tanvi Majumdar, Sarah Refi Hind

Journal: Mol Plant Microbe Interact

PubMed ID: 34732057

Doi: 10.1094/MPMI-08-21-0211-R

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The barley HvSTP13GR mutant triggers resistance against biotrophic fungi

Authors: Caroline Ines Skoppek, Wilko Punt, Marleen Heinrichs, Frank Ordon, Gwendolin Wehner, Jens Boch, Jana Streubel

Journal: Mol Plant Pathol

PubMed ID: 34816582

Doi: 10.1111/mpp.13161

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CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Authors: Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G Venugopala Reddy

Journal: Nat Commun

PubMed ID: 34737298

Doi: 10.1038/s41467-021-26586-0

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Authors: Merveille Eguida, Didier Rognan

Journal: J Cheminform

PubMed ID: 34814950

Doi: 10.1186/s13321-021-00567-3

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Authors: Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

Journal: Oncoimmunology

PubMed ID: 34858730

Doi: 10.1080/2162402X.2021.2005344

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WRKY2 and WRKY10 regulate the circadian expression of during the day through interactions with CCA1/LHY and phyB

Authors: Shulei Wang, Qingbin Sun, Min Zhang, Chengzhu Yin, Min Ni

Journal: Plant Commun

PubMed ID: 35529947

Doi: 10.1016/j.xplc.2021.100265

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Mitochondrial Localization Signal of Porcine Circovirus Type 2 Capsid Protein Plays a Critical Role in Cap-Induced Apoptosis

Authors: Wanting Yu, Yuao Sun, Qing He, Chaoying Sun, Tian Dong, Luhua Zhang, Yang Zhan, Naidong Wang, Yi Yang, Yujie Sun

Journal: Vet Sci

PubMed ID: 34822645

Doi: 10.3390/vetsci8110272

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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae

Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen

Journal: Appl Microbiol Biotechnol

PubMed ID: 34738171

Doi: 10.1007/s00253-021-11661-9

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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee

Journal: Nat Commun

PubMed ID: 34785657

Doi: 10.1038/s41467-021-26733-7

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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

Journal: Elife

PubMed ID: 34761751

Doi: 10.7554/eLife.72798

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs

Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink

Journal: J Biol Chem

PubMed ID: 34798071

Doi: 10.1016/j.jbc.2021.101421

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Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu

Journal: Int J Mol Sci

PubMed ID: 34884691

Doi: 10.3390/ijms222312886

Products & Services: Mammalian Expression

Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging

Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan

Journal: Sci Rep

PubMed ID: 34845270

Doi: 10.1038/s41598-021-02445-2

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Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases

Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent

Journal: J Bacteriol

PubMed ID: 34843376

Doi: 10.1128/JB.00498-21

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response

Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 34818332

Doi: 10.1371/journal.pntd.0009949

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang

Journal: Structure

PubMed ID: 34793709

Doi: 10.1016/j.str.2021.10.013

Products & Services: Proteins, Expression, Isolation and Analysis

Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction

Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang

Journal: J Clin Invest

PubMed ID: 34752417

Doi: 10.1172/JCI151268

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Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain

Authors: Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L Stucky, Quinn H Hogan, Hongwei Yu

Journal: Pain

PubMed ID: 34285153

Doi: 10.1097/j.pain.0000000000002356

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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Authors: Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R Wilmore, Brian T Gaudette, Ousamah Y Soliman, Matthew Pine, Philip Hicks, Tomaz B Manzoni, James J Knox, John L Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M Rosenfeld, Shirin Strohmeier, Paulo J C Lin, Barbara L Mui, Ying K Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P Cancro, Drew Weissman, Eline T Luning Prak, David Allman, Michela Locci, Norbert Pardi

Journal: Immunity

PubMed ID: 34852217

Doi: 10.1016/j.immuni.2021.11.001

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Refinement and Neutralization Evaluation of the F(ab') Type of Antivenom against the Deadly Jellyfish Toxins

Authors: Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li

Journal: Int J Mol Sci

PubMed ID: 34884477

Doi: 10.3390/ijms222312672

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Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment

Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 34740282

Doi: 10.1111/bcpt.13681

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Endotoxin Acts Synergistically With Clostridioides difficile Toxin B to Increase Interleukin 1β Production: A Potential Role for the Intestinal Biome in Modifying the Severity of C difficile Colitis

Authors: Pyae Htwe, Htay Aung, Bohm Kywe, Phyu T Niang, Thar Sann Oo, Sindhu Monhandas, Libusha Kelly, David L Goldman

Journal: J Infect Dis

PubMed ID: 33780547

Doi: 10.1093/infdis/jiab165

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Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model

Authors: Monique C P Mendonça, Michael F Cronin, John F Cryan, Caitriona M O'Driscoll

Journal: Eur J Pharm Biopharm

PubMed ID: 34793942

Doi: 10.1016/j.ejpb.2021.11.003

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Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes

Authors: Yue Lang, Fengna Chu, Lingling Liu, Chao Zheng, Chunrong Li, Donghui Shen, Shan Liu, Weiguanliu Zhang, Li Cui, Jie Zhu

Journal: Clin Exp Immunol

PubMed ID: 35020839

Doi: 10.1093/cei/uxab022

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TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ

Authors: Ruixue Li, Renyong Wang, Shijie Zhong, Farhan Asghar, Tiehan Li, Lei Zhu, Hong Zhu

Journal: Open Life Sci

PubMed ID: 34761110

Doi: 10.1515/biol-2021-0118

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Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E coli without loss of activity

Authors: Melis Denizci Öncü, Bertan Koray Balcıoğlu, Beytullah Özgür, Hasan Ümit Öztürk, Müge Serhatlı, Şeyma Işık, Berrin Erdağ, Gizem Dinler Doğanay, Aylin Özdemir Bahadır

Journal: Biotechnol Appl Biochem

PubMed ID: 34694021

Doi: 10.1002/bab.2273

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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru

Journal: Cell Rep

PubMed ID: 34758302

Doi: 10.1016/j.celrep.2021.109989

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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses

Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek

Journal: Mol Syst Biol

PubMed ID: 34806839

Doi: 10.15252/msb.202110560

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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome

Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan

Journal: Microbiome

PubMed ID: 34814938

Doi: 10.1186/s40168-021-01147-1

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CD4+ effector T cells accelerate Alzheimer's disease in mice

Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman

Journal: J Neuroinflammation

PubMed ID: 34798897

Doi: 10.1186/s12974-021-02308-7

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Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p

Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang

Journal: Cancer Cell Int

PubMed ID: 34844630

Doi: 10.1186/s12935-021-02353-5

Products & Services: Proteins, Expression, Isolation and Analysis

Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick

Journal: MBio

PubMed ID: 34749532

Doi: 10.1128/mBio.02573-21

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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf

Journal: MBio

PubMed ID: 34724812

Doi: 10.1128/mBio.02558-21

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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia

Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati

Journal: J Mol Neurosci

PubMed ID: 34811713

Doi: 10.1007/s12031-021-01945-0

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Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts

Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo

Journal: Front Cell Infect Microbiol

PubMed ID: 34869065

Doi: 10.3389/fcimb.2021.758898

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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection

Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon

Journal: Viruses

PubMed ID: 34835083

Doi: 10.3390/v13112277

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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

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Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily

Authors: Kyrylo Yu Manoilov, Agnidipta Ghosh, Steven C Almo, Vladislav V Verkhusha

Journal: J Mol Biol

PubMed ID: 34798132

Doi: 10.1016/j.jmb.2021.167359

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Authors: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

Journal: Cell Stem Cell

PubMed ID: 34856120

Doi: 10.1016/j.stem.2021.11.003

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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang

Journal: Cancer Cell Int

PubMed ID: 34844614

Doi: 10.1186/s12935-021-02351-7

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The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development

Authors: Hidenori Ito, Rika Morishita, Mariko Noda, Tomoki Ishiguro, Masashi Nishikawa, Koh-Ichi Nagata

Journal: J Biol Chem

PubMed ID: 34800437

Doi: 10.1016/j.jbc.2021.101427

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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Authors: Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy

Journal: Microorganisms

PubMed ID: 34835449

Doi: 10.3390/microorganisms9112323

Products & Services: Proteins, Expression, Isolation and Analysis

An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Authors: Anja Ziegler, Judith Olzhausen, Eman Hamza, Ana Stojiljkovic, Michael H Stoffel, Mattia Garbani, Claudio Rhyner, Eliane Marti

Journal: Vet Immunol Immunopathol

PubMed ID: 34800874

Doi: 10.1016/j.vetimm.2021.110351

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Positively Regulates Pepper Immunity by Targeting against Inoculation through Modulating Defense-Related Genes

Authors: Ansar Hussain, Muhammad Ifnan Khan, Mohammed Albaqami, Shahzadi Mahpara, Ijaz Rasool Noorka, Mohamed A A Ahmed, Bandar S Aljuaid, Ahmed M El-Shehawi, Zhiqin Liu, Shahid Farooq, Ali Tan Kee Zuan

Journal: Int J Mol Sci

PubMed ID: 34769521

Doi: 10.3390/ijms222112091

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The pleiotropic functions of intracellular hydrophobins in aerial hyphae and fungal spores

Authors: Feng Cai, Zheng Zhao, Renwei Gao, Peijie Chen, Mingyue Ding, Siqi Jiang, Zhifei Fu, Pingyong Xu, Komal Chenthamara, Qirong Shen, Günseli Bayram Akcapinar, Irina S Druzhinina

Journal: PLoS Genet

PubMed ID: 34788288

Doi: 10.1371/journal.pgen.1009924

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A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum

Authors: Tarkeshwar Kumar, Satarupa Maitra, Abdur Rahman, Souvik Bhattacharjee

Journal: PLoS Pathog

PubMed ID: 34780541

Doi: 10.1371/journal.ppat.1009595

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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv oryzae

Authors: Yuejing Gui, Dongsheng Tian, Kar Hui Ong, Joanne Chin Yi Teo, Zhongchao Yin

Journal: Transgenic Res

PubMed ID: 34748132

Doi: 10.1007/s11248-021-00290-7

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Microinjection of pruritogens in NGF-sensitized human skin

Authors: Hans Jürgen Solinski, Roman Rukwied, Martin Schmelz

Journal: Sci Rep

PubMed ID: 34728705

Doi: 10.1038/s41598-021-00935-x

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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Authors: Daniel T Johnson, Jiarong Zhou, Ashley V Kroll, Ronnie H Fang, Ming Yan, Crystal Xiao, Xiufen Chen, Justin Kline, Liangfang Zhang, Dong-Er Zhang

Journal: Leukemia

PubMed ID: 34845316

Doi: 10.1038/s41375-021-01432-w

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ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments

Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal

Journal: Molecules

Doi: 10.3390/molecules26237155

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A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library

Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun

Journal: Front Oncol.

PubMed ID: 34912719

Doi: doi.org/10.3389/fonc.2021.781046

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SARS-CoV-2 exposure in wild white-tailed deer ()

Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34732584

Doi: 10.1073/pnas.2114828118

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Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Authors: Mohamed S Abdel-Hakeem, Sasikanth Manne, Jean-Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L Johnson, Josephine R Giles, Divij Mathew, Allison R Greenplate, Golnaz Vahedi, E John Wherry

Journal: Nat Immunol

PubMed ID: 34588688

Doi: 10.1038/s41590-021-01057-2

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Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China

Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan

Journal: Innovation (N Y)

PubMed ID: 34746904

Doi: 10.1016/j.xinn.2021.100181

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Heterologous Expression of a Thermostable Chitinase from and Its Application for High Yield Production of Glucosamine from Shrimp Shell

Authors: Yongmei Lyu, Feng Zheng, Chuanxing Qiu, Meng Wang, Dujun Wang, Xiaoyang Zhang, Josef Voglmeir, Li Liu, Xiaohong Yu

Journal: Foods

PubMed ID: 34829089

Doi: 10.3390/foods10112808

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Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection

Authors: Sun Hee Moon, Yihong Kaufmann, Ryoichi Fujiwara, En Huang

Journal: BMC Microbiol

PubMed ID: 34819026

Doi: 10.1186/s12866-021-02383-z

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Surface-Functionalized Silica-Coated Calcium Phosphate Nanoparticles Efficiently Deliver DNA-Based HIV-1 Trimeric Envelope Vaccines against HIV-1

Authors: Shuang Li, Bo Wang, Shun Jiang, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: ACS Appl Mater Interfaces

PubMed ID: 34735127

Doi: 10.1021/acsami.1c16989

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LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3

Authors: Jing Li, Xiaojie Quan, Saifei Lei, Gang Chen, Jiawei Hong, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang

Journal: Environ Pollut

PubMed ID: 34801623

Doi: 10.1016/j.envpol.2021.118542

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Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine suicide system for canine melanoma

Authors: Gerardo C Glikin, Jesica B Allende, Liliana M E Finocchiaro

Journal: Vet Comp Oncol

PubMed ID: 34724324

Doi: 10.1111/vco.12780

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Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit

Authors: Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere, Lennart Martens, Sven Degroeve, Wim De Neve, Wim Vranken, Nico Callewaert

Journal: Nat Commun

PubMed ID: 34741024

Doi: 10.1038/s41467-021-26720-y

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The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function

Authors: Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T Burgess, Mark N Adams, Kenneth J O'Byrne, Derek J Richard, Neha S Gandhi, Emma Bolderson

Journal: Front Cell Dev Biol

PubMed ID: 34820387

Doi: 10.3389/fcell.2021.775441

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Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system

Authors: Federico Camicia, Hugo R Vaca, Sang-Kyu Park, Augusto E Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M Celentano, Jonathan S Marchant, Mara C Rosenzvit

Journal: PLoS ONE

PubMed ID: 34762657

Doi: 10.1371/journal.pone.0259104

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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel-Hagen, Christopher S Seet, Gay M Crooks, Sarah M Larson, Joshua P Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B Kohn, Owen Witte, Pin Wang, Lili Yang

Journal: Cell Rep Med

PubMed ID: 34841295

Doi: 10.1016/j.xcrm.2021.100449

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G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D receptor desensitization

Authors: Richard Ågren, Kristoffer Sahlholm

Journal: FASEB J

PubMed ID: 34699610

Doi: 10.1096/fj.202100704RR

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