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Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes
Authors: Yue Lang, Fengna Chu, Lingling Liu, Chao Zheng, Chunrong Li, Donghui Shen, Shan Liu, Weiguanliu Zhang, Li Cui, Jie Zhu
Journal: Clin Exp Immunol
PubMed ID: 35020839
Doi: 10.1093/cei/uxab022
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TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ
Authors: Ruixue Li, Renyong Wang, Shijie Zhong, Farhan Asghar, Tiehan Li, Lei Zhu, Hong Zhu
Journal: Open Life Sci
PubMed ID: 34761110
Doi: 10.1515/biol-2021-0118
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Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E coli without loss of activity
Authors: Melis Denizci Öncü, Bertan Koray Balcıoğlu, Beytullah Özgür, Hasan Ümit Öztürk, Müge Serhatlı, Şeyma Işık, Berrin Erdağ, Gizem Dinler Doğanay, Aylin Özdemir Bahadır
Journal: Biotechnol Appl Biochem
PubMed ID: 34694021
Doi: 10.1002/bab.2273
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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling
Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru
Journal: Cell Rep
PubMed ID: 34758302
Doi: 10.1016/j.celrep.2021.109989
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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses
Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek
Journal: Mol Syst Biol
PubMed ID: 34806839
Doi: 10.15252/msb.202110560
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Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment
Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl
Journal: Basic Clin Pharmacol Toxicol
PubMed ID: 34740282
Doi: 10.1111/bcpt.13681
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Highly portable quantitative screening test for prostate-specific antigen at point of care
Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta
Journal: Curr Res Biotechnol
PubMed ID: 35083431
Doi: 10.1016/j.crbiot.2021.11.003
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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review
Authors:
Journal: Clin Lab Med
PubMed ID: 35153046
Doi: 10.1016/j.cll.2021.10.006
Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in
Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu
Journal: Front Plant Sci
PubMed ID: 34880887
Doi: 10.3389/fpls.2021.760379
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Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain
Authors: Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L Stucky, Quinn H Hogan, Hongwei Yu
Journal: Pain
PubMed ID: 34285153
Doi: 10.1097/j.pain.0000000000002356
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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication
Authors: Sai Wang, Kitti Wing Ki Chan, Min Jie Alvin Tan, Charlotte Flory, Dahai Luo, Julian Lescar, Jade K Forwood, Subhash G Vasudevan
Journal: RNA
PubMed ID: 34759006
Doi: 10.1261/rna.078949.121
Products & Services: Mammalian Expression   
WRKY2 and WRKY10 regulate the circadian expression of during the day through interactions with CCA1/LHY and phyB
Authors: Shulei Wang, Qingbin Sun, Min Zhang, Chengzhu Yin, Min Ni
Journal: Plant Commun
PubMed ID: 35529947
Doi: 10.1016/j.xplc.2021.100265
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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Authors: Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R Wilmore, Brian T Gaudette, Ousamah Y Soliman, Matthew Pine, Philip Hicks, Tomaz B Manzoni, James J Knox, John L Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M Rosenfeld, Shirin Strohmeier, Paulo J C Lin, Barbara L Mui, Ying K Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P Cancro, Drew Weissman, Eline T Luning Prak, David Allman, Michela Locci, Norbert Pardi
Journal: Immunity
PubMed ID: 34852217
Doi: 10.1016/j.immuni.2021.11.001
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Refinement and Neutralization Evaluation of the F(ab') Type of Antivenom against the Deadly Jellyfish Toxins
Authors: Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li
Journal: Int J Mol Sci
PubMed ID: 34884477
Doi: 10.3390/ijms222312672
Products & Services: Proteins, Expression, Isolation and Analysis   
Mediates Hormonally Regulated Dominance Rank in a Social Bee
Authors: Atul Pandey, Guy Bloch
Journal: Biology (Basel)
PubMed ID: 34827180
Doi: 10.3390/biology10111188
Products & Services: Molecular Biology Tools   
A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells
Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee, Chae Rim Lee, Da-Som Kim, Yang-Mi Her, Jeong Won Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho
Journal: Cell Mol Immunol
PubMed ID: 34782759
Doi: 10.1038/s41423-021-00798-2
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High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study
Authors: Andres Moreira-Soto, Johanna Maribel Pachamora Diaz, Lilian González-Auza, Xiomara Jeanleny Merino Merino, Alvaro Schwalb, Christian Drosten, Eduardo Gotuzzo, Michael Talledo, Heriberto Arévalo Ramirez, Roxana Peralta Delgado, Spassky Bocanegra Vargas, Jan Felix Drexler
Journal: mSphere
PubMed ID: 34817236
Doi: 10.1128/mSphere.00685-21
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The multicellular signalling network of ovarian cancer metastases
Authors: Leah Sommerfeld, Florian Finkernagel, Julia M Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Anna M Sokol, Johannes Graumann, Silke Reinartz, Rolf Müller
Journal: Clin Transl Med
PubMed ID: 34841720
Doi: 10.1002/ctm2.633
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A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins
Authors: Gang Liu, Dong-Yun Zuo, Peng Yang, Wei-Jie He, Zheng Yang, Jing-Bo Zhang, Ai-Bo Wu, Shu-Yuan Yi, He-Ping Li, Tao Huang, Yu-Cai Liao
Journal: J Fungi (Basel)
PubMed ID: 34829228
Doi: 10.3390/jof7110941
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Influence of flagellin polymorphisms, gene regulation, and responsive memory on the motility of species that cause bacterial spot disease of solanaceous plants
Authors: Maria Laura Malvino, Amie Joy Bott, Cory Edwin Green, Tanvi Majumdar, Sarah Refi Hind
Journal: Mol Plant Microbe Interact
PubMed ID: 34732057
Doi: 10.1094/MPMI-08-21-0211-R
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The barley HvSTP13GR mutant triggers resistance against biotrophic fungi
Authors: Caroline Ines Skoppek, Wilko Punt, Marleen Heinrichs, Frank Ordon, Gwendolin Wehner, Jens Boch, Jana Streubel
Journal: Mol Plant Pathol
PubMed ID: 34816582
Doi: 10.1111/mpp.13161
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CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient
Authors: Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G Venugopala Reddy
Journal: Nat Commun
PubMed ID: 34737298
Doi: 10.1038/s41467-021-26586-0
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Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision
Authors: Merveille Eguida, Didier Rognan
Journal: J Cheminform
PubMed ID: 34814950
Doi: 10.1186/s13321-021-00567-3
Products & Services: Mammalian Expression   
The concentration of brain homogenates with the Amicon Ultra Centrifugal filters
Authors: Joshua Yang, Rachita K Sumbria
Journal: MethodsX
PubMed ID: 35004217
Doi: 10.1016/j.mex.2021.101584
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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis
Authors: Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich
Journal: Oncoimmunology
PubMed ID: 34858730
Doi: 10.1080/2162402X.2021.2005344
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H,  N and  C resonance assignments of the Q61H mutant of human KRAS bound to GDP
Authors: Qiwei Huang, Elizabeth Yihui Ng, Qingxin Li, CongBao Kang
Journal: Biomol NMR Assign
PubMed ID: 34787842
Doi: 10.1007/s12104-021-10058-z
Products & Services: Mammalian Expression   
Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury
Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu
Journal: Int J Mol Sci
PubMed ID: 34884691
Doi: 10.3390/ijms222312886
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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response
Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao
Journal: PLoS Negl Trop Dis
PubMed ID: 34818332
Doi: 10.1371/journal.pntd.0009949
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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae
Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen
Journal: Appl Microbiol Biotechnol
PubMed ID: 34738171
Doi: 10.1007/s00253-021-11661-9
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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides
Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee
Journal: Nat Commun
PubMed ID: 34785657
Doi: 10.1038/s41467-021-26733-7
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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao
Journal: Elife
PubMed ID: 34761751
Doi: 10.7554/eLife.72798
Products & Services: Proteins, Expression, Isolation and Analysis   
Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs
Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink
Journal: J Biol Chem
PubMed ID: 34798071
Doi: 10.1016/j.jbc.2021.101421
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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf
Journal: MBio
PubMed ID: 34724812
Doi: 10.1128/mBio.02558-21
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Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging
Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan
Journal: Sci Rep
PubMed ID: 34845270
Doi: 10.1038/s41598-021-02445-2
Products & Services: Proteins, Expression, Isolation and Analysis   
Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases
Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent
Journal: J Bacteriol
PubMed ID: 34843376
Doi: 10.1128/JB.00498-21
Products & Services: Proteins, Expression, Isolation and Analysis   
Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex
Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang
Journal: Structure
PubMed ID: 34793709
Doi: 10.1016/j.str.2021.10.013
Products & Services: Proteins, Expression, Isolation and Analysis   
Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction
Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang
Journal: J Clin Invest
PubMed ID: 34752417
Doi: 10.1172/JCI151268
Products & Services: Proteins, Expression, Isolation and Analysis   
Mitochondrial Localization Signal of Porcine Circovirus Type 2 Capsid Protein Plays a Critical Role in Cap-Induced Apoptosis
Authors: Wanting Yu, Yuao Sun, Qing He, Chaoying Sun, Tian Dong, Luhua Zhang, Yang Zhan, Naidong Wang, Yi Yang, Yujie Sun
Journal: Vet Sci
PubMed ID: 34822645
Doi: 10.3390/vetsci8110272
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Inducing I and phase 1 repolarization of the cardiac action potential with a Kv43/KChIP21 bicistronic transgene
Authors: Nan Wang, Eef Dries, Ewan D Fowler, Stephen C Harmer, Jules C Hancox, Mark B Cannell
Journal: J Mol Cell Cardiol
PubMed ID: 34823101
Doi: 10.1016/j.yjmcc.2021.11.004
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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome
Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan
Journal: Microbiome
PubMed ID: 34814938
Doi: 10.1186/s40168-021-01147-1
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CD4+ effector T cells accelerate Alzheimer's disease in mice
Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman
Journal: J Neuroinflammation
PubMed ID: 34798897
Doi: 10.1186/s12974-021-02308-7
Products & Services: Recombinant Proteins   
Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p
Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang
Journal: Cancer Cell Int
PubMed ID: 34844630
Doi: 10.1186/s12935-021-02353-5
Products & Services: Proteins, Expression, Isolation and Analysis   
Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri
Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick
Journal: MBio
PubMed ID: 34749532
Doi: 10.1128/mBio.02573-21
Products & Services: Plasmid DNA Preparation   
MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia
Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati
Journal: J Mol Neurosci
PubMed ID: 34811713
Doi: 10.1007/s12031-021-01945-0
Products & Services: Molecular Biology Tools   
Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts
Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo
Journal: Front Cell Infect Microbiol
PubMed ID: 34869065
Doi: 10.3389/fcimb.2021.758898
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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection
Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon
Journal: Viruses
PubMed ID: 34835083
Doi: 10.3390/v13112277
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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution
Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda
Journal: ACS Omega
PubMed ID: 34841168
Doi: 10.1021/acsomega.1c04982
Products & Services: Plasmid DNA Preparation   
Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily
Authors: Kyrylo Yu Manoilov, Agnidipta Ghosh, Steven C Almo, Vladislav V Verkhusha
Journal: J Mol Biol
PubMed ID: 34798132
Doi: 10.1016/j.jmb.2021.167359
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Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine
Authors: Felipe Melo-González, Jorge A Soto, Liliana A González, Jorge Fernández, Luisa F Duarte, Bárbara M Schultz, Nicolás M S Gálvez, Gaspar A Pacheco, Mariana Ríos, Yaneisi Vázquez, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Carolina Iturriaga, Omar P Vallejos, Roslye V Berríos-Rojas, Guillermo Hoppe-Elsholz, Marcela Urzúa, Nicole Bruneau, Rodrigo A Fasce, Judith Mora, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Gang Zeng, Weining Meng, José V González-Aramundiz, Pablo A González, Katia Abarca, Eugenio Ramírez, Alexis M Kalergis, Susan M Bueno
Journal: Front Immunol
PubMed ID: 34858404
Doi: 10.3389/fimmu.2021.747830
Products & Services: Recombinant Antibody Expression   
Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies
Authors: Rashmi Patel, Siddharth Khare, Vinay S Mahajan
Journal: Clin Lab Med
PubMed ID: 35153048
Doi: 10.1016/j.cll.2021.10.007
A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and Display
Authors: Krista G Freeman, Katherine S Wetzel, Yu Zhang, Kira M Zack, Deborah Jacobs-Sera, Sara M Walters, Dominique J Barbeau, Anita K McElroy, John V Williams, Graham F Hatfull
Journal: Microorganisms
PubMed ID: 34946016
Doi: 10.3390/microorganisms9122414
Products & Services: Recombinant Antibody Expression   
Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
Authors: Hui-Tsu Lin, Cheng-Cheung Chen, Der-Jiang Chiao, Tein-Yao Chang, Xin-An Chen, Jenn-Jong Young, Szu-Cheng Kuo
Journal: Int J Biol Macromol
PubMed ID: 34774590
Doi: 10.1016/j.ijbiomac.2021.11.020
Products & Services: Insect Expression   
Nanovaccines Mediated Subcutis-to-Intestine Cascade for Improved Protection against Intestinal Infections
Authors: Xiaofang Zhong, Guangsheng Du, Xuanyu Wang, Yangsen Ou, Hairui Wang, Yining Zhu, Xinyan Hao, Zhiqiang Xie, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Journal: Small
PubMed ID: 34825482
Doi: 10.1002/smll.202105530
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Baculovirus Vectors Induce the Production of Interferons in Swine: Their Potential in the Development of Antiviral Strategies
Authors: Guido Nicolás Molina, Sabrina Amalfi, Ignacio Otero, Oscar Taboga, María Paula Molinari
Journal: Vet Sci
PubMed ID: 34822651
Doi: 10.3390/vetsci8110278
Products & Services: Plasmid DNA Preparation   
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity
Authors: Debabrata Chowdhury, Jason C Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo, Julio A Landero Figueroa, Kavitha Subramanian Vignesh
Journal: Front Immunol
PubMed ID: 34867993
Doi: 10.3389/fimmu.2021.755961
Products & Services: Proteins, Expression, Isolation and Analysis   
Long Non-Coding RNA Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development
Authors: Elpinickie Ninou, Artemis Michail, Panagiotis K Politis
Journal: Front Cell Dev Biol
PubMed ID: 34900989
Doi: 10.3389/fcell.2021.726857
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Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos
Authors: Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya M Colpitts, Stephanie E Mohr, Yanhui Hu, Norbert Perrimon
Journal: Nat Commun
PubMed ID: 34819517
Doi: 10.1038/s41467-021-27129-3
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An Efficient Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Protein 9 Mutagenesis System for Oil Palm ()
Authors: Wan-Chin Yeap, Muhammad Rashdan Muad, David Ross Appleton
Journal: Front Plant Sci
PubMed ID: 34880893
Doi: 10.3389/fpls.2021.773656
Products & Services: Gene Synthesis   
SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells
Authors: Dante Barreda, César Santiago, Juan R Rodríguez, José F Rodríguez, José M Casasnovas, Isabel Mérida, Antonia Ávila-Flores
Journal: Cells
PubMed ID: 34943787
Doi: 10.3390/cells10123279
Products & Services: Protein Reagents and Products   
Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients
Authors: Belén G Sanchez, Jose M Gasalla, Manuel Sánchez-Chapado, Alicia Bort, Inés Diaz-Laviada
Journal: J Clin Med
PubMed ID: 34884175
Doi: 10.3390/jcm10235474
Products & Services: Mammalian Expression   
Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region
Authors: Junping Hong, Dongmei Wei, Qian Wu, Ling Zhong, Kaiyun Chen, Yang Huang, Wanlin Zhang, Junyu Chen, Ningshao Xia, Xiao Zhang, Yixin Chen
Journal: Viruses
PubMed ID: 34960650
Doi: 10.3390/v13122380
Products & Services: Proteins, Expression, Isolation and Analysis   
The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer
Authors: Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M Noordermeer, Toshiro K Ohsumi, Nicole Hustedt, Rachel K Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T F Young, Michael Zinda, Manuel Stucki, Daniel Durocher
Journal: Nat Cancer
PubMed ID: 35121901
Doi: 10.1038/s43018-021-00266-w
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
Authors: Chensu Wang, Ang Cui, Maurice Bukenya, Aereas Aung, Dikshant Pradhan, Charles A Whittaker, Yash Agarwal, Ayush Thomas, Simon Liang, Parastoo Amlashi, Heikyung Suh, Stefani Spranger, Nir Hacohen, Darrell J Irvine
Journal: Cell Rep
PubMed ID: 34818534
Doi: 10.1016/j.celrep.2021.110021
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Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling
Authors: In-Chi Young, Bogang Wu, Jaclyn Andricovich, Sung-Ting Chuang, Rong Li, Alexandros Tzatsos, Ray-Chang Wu, Mei-Yi Wu
Journal: Cell Rep
PubMed ID: 34818550
Doi: 10.1016/j.celrep.2021.110036
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Assessment of in vitro activities of novel modified antimicrobial peptides against clarithromycin resistant Mycobacterium abscessus
Authors: Phantitra Sudadech, Sittiruk Roytrakul, Orawee Kaewprasert, Auttawit Sirichoat, Ploenchan Chetchotisakd, Sakawrat Kanthawong, Kiatichai Faksri
Journal: PLoS ONE
PubMed ID: 34780520
Doi: 10.1371/journal.pone.0260003
Products & Services: Peptide Synthesis   
A molecular dynamics-guided mutagenesis identifies two aspartic acid residues involved in the pH-dependent activity of OG-OXIDASE 1
Authors: Anna Scortica, Matteo Capone, Daniele Narzi, Mario Frezzini, Valentina Scafati, Moira Giovannoni, Francesco Angelucci, Leonardo Guidoni, Benedetta Mattei, Manuel Benedetti
Journal: Plant Physiol Biochem
PubMed ID: 34800821
Doi: 10.1016/j.plaphy.2021.11.011
Products & Services: Gene Synthesis   
Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection
Authors: Henry Daniell, Smruti K Nair, Nardana Esmaeili, Geetanjali Wakade, Naila Shahid, Prem Kumar Ganesan, Md Reyazul Islam, Ariel Shepley-McTaggart, Sheng Feng, Ebony N Gary, Ali R Ali, Manunya Nuth, Selene Nunez Cruz, Jevon Graham-Wooten, Stephen J Streatfield, Ruben Montoya-Lopez, Paul Kaznica, Margaret Mawson, Brian J Green, Robert Ricciardi, Michael Milone, Ronald N Harty, Ping Wang, David B Weiner, Kenneth B Margulies, Ronald G Collman
Journal: Mol Ther
PubMed ID: 34774754
Doi: 10.1016/j.ymthe.2021.11.008
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The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway
Authors: Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang
Journal: Bioengineered
PubMed ID: 34783297
Doi: 10.1080/21655979.2021.2005932
Products & Services: Plasmid DNA Preparation   
Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant
Authors: Ehab Al-Moubarak, Holly A Shiels, Yihong Zhang, Chunyun Du, Oliver Hanington, Stephen C Harmer, Christopher E Dempsey, Jules C Hancox
Journal: Cell Mol Life Sci
PubMed ID: 34727194
Doi: 10.1007/s00018-021-03967-8
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The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain
Authors: María Rodríguez-Muñoz, Elsa Cortés-Montero, Yara Onetti, Pilar Sánchez-Blázquez, Javier Garzón-Niño
Journal: Biomolecules
PubMed ID: 34827679
Doi: 10.3390/biom11111681
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Authors: Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L Udaskin, Ahmet Mentes, Richard Huang, Betty P K Poon, Wenguang He, Ivette Valencia-Sama, Claire M Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S Irwin, Jeffrey E Lee, Ming-Sound Tsao, Brian Raught, Christopher B Marshall, Michael Ohh, Mitsuhiko Ikura
Journal: Nat Commun
PubMed ID: 34725361
Doi: 10.1038/s41467-021-26526-y
Products & Services: Bacterial Expression   
Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells
Authors: Yuanyuan Shi, Jian Chen, Wei-Jie Zeng, Miao Li, Wenxue Zhao, Xing-Ding Zhang, Jie Yao
Journal: BMC Biol
PubMed ID: 34789250
Doi: 10.1186/s12915-021-01178-y
Products & Services: Gene Synthesis   
Tasquinimod efficacy and S100A9 expression in glucose-treated HREC cells
Authors: Ji Jin, Ji Zhang, Shuyang Bu
Journal: Int Ophthalmol
PubMed ID: 34796432
Doi: 10.1007/s10792-021-02038-y
Products & Services: Gene Synthesis   
DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
Authors: Ronghui Lou, Weizhen Liu, Rongjie Li, Shanshan Li, Xuming He, Wenqing Shui
Journal: Nat Commun
PubMed ID: 34795227
Doi: 10.1038/s41467-021-26979-1
Products & Services: Peptide Synthesis   
ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments
Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal
Journal: Molecules
Doi: 10.3390/molecules26237155
Products & Services: Gene Synthesis   
A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library
Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun
Journal: Front Oncol.
PubMed ID: 34912719
Doi: doi.org/10.3389/fonc.2021.781046
Products & Services: Recombinant Proteins   
SARS-CoV-2 exposure in wild white-tailed deer ()
Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner
Journal: Proc Natl Acad Sci U S A
PubMed ID: 34732584
Doi: 10.1073/pnas.2114828118
Products & Services: Serology SARS-Cov-2 detection kits   
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
Authors: Mohamed S Abdel-Hakeem, Sasikanth Manne, Jean-Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L Johnson, Josephine R Giles, Divij Mathew, Allison R Greenplate, Golnaz Vahedi, E John Wherry
Journal: Nat Immunol
PubMed ID: 34588688
Doi: 10.1038/s41590-021-01057-2
Products & Services: Recombinant Proteins   
Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China
Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan
Journal: Innovation (N Y)
PubMed ID: 34746904
Doi: 10.1016/j.xinn.2021.100181
Products & Services: Proteins, Expression, Isolation and Analysis   
Heterologous Expression of a Thermostable Chitinase from and Its Application for High Yield Production of Glucosamine from Shrimp Shell
Authors: Yongmei Lyu, Feng Zheng, Chuanxing Qiu, Meng Wang, Dujun Wang, Xiaoyang Zhang, Josef Voglmeir, Li Liu, Xiaohong Yu
Journal: Foods
PubMed ID: 34829089
Doi: 10.3390/foods10112808
Products & Services: Proteins, Expression, Isolation and Analysis   
Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection
Authors: Sun Hee Moon, Yihong Kaufmann, Ryoichi Fujiwara, En Huang
Journal: BMC Microbiol
PubMed ID: 34819026
Doi: 10.1186/s12866-021-02383-z
Products & Services: Proteins, Expression, Isolation and Analysis   
Surface-Functionalized Silica-Coated Calcium Phosphate Nanoparticles Efficiently Deliver DNA-Based HIV-1 Trimeric Envelope Vaccines against HIV-1
Authors: Shuang Li, Bo Wang, Shun Jiang, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan
Journal: ACS Appl Mater Interfaces
PubMed ID: 34735127
Doi: 10.1021/acsami.1c16989
Products & Services: Plasmid DNA Preparation   
LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3
Authors: Jing Li, Xiaojie Quan, Saifei Lei, Gang Chen, Jiawei Hong, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang
Journal: Environ Pollut
PubMed ID: 34801623
Doi: 10.1016/j.envpol.2021.118542
Products & Services: Plasmid DNA Preparation   
Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine suicide system for canine melanoma
Authors: Gerardo C Glikin, Jesica B Allende, Liliana M E Finocchiaro
Journal: Vet Comp Oncol
PubMed ID: 34724324
Doi: 10.1111/vco.12780
Products & Services: PCR Cloning and Subcloning   
Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
Authors: Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere, Lennart Martens, Sven Degroeve, Wim De Neve, Wim Vranken, Nico Callewaert
Journal: Nat Commun
PubMed ID: 34741024
Doi: 10.1038/s41467-021-26720-y
Products & Services: PCR Cloning and Subcloning   
The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function
Authors: Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T Burgess, Mark N Adams, Kenneth J O'Byrne, Derek J Richard, Neha S Gandhi, Emma Bolderson
Journal: Front Cell Dev Biol
PubMed ID: 34820387
Doi: 10.3389/fcell.2021.775441
Products & Services: PCR Cloning and Subcloning   
Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system
Authors: Federico Camicia, Hugo R Vaca, Sang-Kyu Park, Augusto E Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M Celentano, Jonathan S Marchant, Mara C Rosenzvit
Journal: PLoS ONE
PubMed ID: 34762657
Doi: 10.1371/journal.pone.0259104
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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
Authors: Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel-Hagen, Christopher S Seet, Gay M Crooks, Sarah M Larson, Joshua P Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B Kohn, Owen Witte, Pin Wang, Lili Yang
Journal: Cell Rep Med
PubMed ID: 34841295
Doi: 10.1016/j.xcrm.2021.100449
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G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D receptor desensitization
Authors: Richard Ågren, Kristoffer Sahlholm
Journal: FASEB J
PubMed ID: 34699610
Doi: 10.1096/fj.202100704RR
Products & Services: DNA Sequencing   
MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3
Authors: Xiaochen Hu, Hongjun Miao
Journal: Mol Biol Rep
PubMed ID: 34757596
Doi: 10.1007/s11033-021-06849-1
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Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances
Authors: Madison M Mann, James D Tang, Bryan W Berger
Journal: Biotechnol Bioeng
PubMed ID: 34723386
Doi: 10.1002/bit.27981
Products & Services: Custom Vector Construction   
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
Authors: Jasmine George, Yongsheng Li, Ishaque P Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S Rader, Anil K Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Journal: Cell Rep
PubMed ID: 34731628
Doi: 10.1016/j.celrep.2021.109934
Products & Services: Custom DNA/RNA Oligos   
G3BP1 inhibits Cul3 to amplify AR signaling and promote prostate cancer
Authors: Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian D Robinson, Arul M Chinnaiyan, Mark A Rubin, Christopher E Barbieri, Pengbo Zhou
Journal: Nat Commun
PubMed ID: 34795264
Doi: 10.1038/s41467-021-27024-x
The B-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine
Authors: William G Walls, James D Moody, Elizabeth C McDaniel, Maria Villanueva, Eric M Shepard, William E Broderick, Joan B Broderick
Journal: J Inorg Biochem
PubMed ID: 34847521
Doi: 10.1016/j.jinorgbio.2021.111662
Products & Services: Codon Optimization   
Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation
Authors: Marek Jindra, William J McKinstry, Thomas Nebl, Lenka Bittova, Bin Ren, Jan Shaw, Tram Phan, Louis Lu, Jason K K Low, Joel P Mackay, Lindsay G Sparrow, George O Lovrecz, Ronald J Hill
Journal: J Biol Chem
PubMed ID: 34758356
Doi: 10.1016/j.jbc.2021.101387
Products & Services: Codon Optimization   
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products
Authors: Julia K Lewis, Andrew S Jochimsen, Sarah J Lefave, Anthony P Young, William M Kincannon, Andrew G Roberts, Matthew T Kieber-Emmons, Vahe Bandarian
Journal: Biochemistry
PubMed ID: 34730336
Doi: 10.1021/acs.biochem.1c00469
Products & Services: Codon Optimization   
In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum
Authors: Luis Ariel Espinosa, Yassel Ramos, Ivan Andújar, Enso Onill Torres, Gleysin Cabrera, Alejandro Martín, Diamilé Roche, Glay Chinea, Mónica Becquet, Isabel González, Camila Canaán-Haden, Elías Nelson, Gertrudis Rojas, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Tamy Boggiano, Julio Palacio, Sum Lai Lozada Chang, Lourdes Hernández, Kathya Rashida de la Luz Hernández, Saloheimo Markku, Marika Vitikainen, Yury Valdés-Balbín, Darielys Santana-Medero, Daniel G Rivera, Vicente Vérez-Bencomo, Mark Emalfarb, Ronen Tchelet, Gerardo Guillén, Miladys Limonta, Eulogio Pimentel, Marta Ayala, Vladimir Besada, Luis Javier González
Journal: Anal Bioanal Chem
PubMed ID: 34739558
Doi: 10.1007/s00216-021-03721-w
Products & Services: Codon Optimization   
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant
Authors: Bassel Akache, Tyler M Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A Harrison, Diana Duque, Julie Haukenfrers, Martin A Rossotti, Francis Gaudreault, Usha D Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J McCluskie
Journal: Sci Rep
PubMed ID: 34750472
Doi: 10.1038/s41598-021-01363-7
Products & Services: Codon Optimization   
Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Authors: Barbora Novotná, Lucie Holá, Monika Staś, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zdeněk Vavřina, Miloš Buděšínský, Radek Liboska, Florian Chevrier, Juraj Dobiaš, Evzen Boura, Lubomír Rulíšek, Gabriel Birkuš
Journal: Biochemistry
PubMed ID: 34788017
Doi: 10.1021/acs.biochem.1c00692
Products & Services: Codon Optimization   
Two C1-oxidizing AA9 lytic polysaccharide monooxygenases from Sordaria brevicollis differ in thermostability, activity, and synergy with cellulase
Authors: Xi Zhang, Kaixiang Chen, Liangkun Long, Shaojun Ding
Journal: Appl Microbiol Biotechnol
PubMed ID: 34748039
Doi: 10.1007/s00253-021-11677-1
Products & Services: Codon Optimization   

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