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Molecular spikes: a gold standard for single-cell RNA counting

Authors: Christoph Ziegenhain, Gert-Jan Hendriks, Michael Hagemann-Jensen, Rickard Sandberg

Journal: Nat Methods

PubMed ID: 35468967

Doi: 10.1038/s41592-022-01446-x

Products & Services: Gene Synthesis

NADH oxidase of Mycoplasma hyopneumoniae functions as a potential mediator of virulence

Authors: Fei Hao, Xing Xie, Zhixin Feng, Rong Chen, Yanna Wei, Jin Liu, Qiyan Xiong, Guoqing Shao, Johnson Lin

Journal: BMC Vet Res

PubMed ID: 35366872

Doi: 10.1186/s12917-022-03230-7

Products & Services: Bacterial Expression

Transcriptome analysis reveals the regulatory mechanism by which suppresses adventitious shoot formation in apple

Authors: Jiangping Mao, Doudou Ma, Chundong Niu, Xiaolong Ma, Ke Li, Muhammad Mobeen Tahir, Shiyue Chen, Xiuxiu Liu, Dong Zhang

Journal: Hortic Res

PubMed ID: 35669707

Doi: 10.1093/hr/uhac080

Products & Services: Polyclonal Antibody Services

Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp Hel_I_6 consumes alpha-mannan from fungi

Authors: Vipul Solanki, Karen Krüger, Conor J Crawford, Alonso Pardo-Vargas, José Danglad-Flores, Kim Le Mai Hoang, Leeann Klassen, D Wade Abbott, Peter H Seeberger, Rudolf I Amann, Hanno Teeling, Jan-Hendrik Hehemann

Journal: ISME J

PubMed ID: 35414716

Doi: 10.1038/s41396-022-01223-w

Products & Services: Plasmid DNA Preparation

Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Authors: Zhe Li, Hao Zhang, Chunjing Cai, Zhong Lin, Zhen Zhen, Jie Chu, Kai Guo

Journal: Appl Microbiol Biotechnol

PubMed ID: 35376971

Doi: 10.1007/s00253-022-11897-z

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Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata

Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li

Journal: Nat Commun

PubMed ID: 35468919

Doi: 10.1038/s41467-022-29908-y

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Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire

Journal: Commun Biol

PubMed ID: 35411021

Doi: 10.1038/s42003-022-03262-7

Products & Services: Recombinant Proteins

Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers

Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai

Journal: Vaccine

PubMed ID: 35430106

Doi: 10.1016/j.vaccine.2022.04.020

Topology of the Enterobacterial Common Antigen polymerase WzyE

Authors: Nicholas T Maczuga, Elizabeth N H Tran, Renato Morona

Journal: Microbiology (Reading)

PubMed ID: 35470793

Doi: 10.1099/mic.0.001183

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Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

Authors: Jessica Hong, Hyung Joon Kwon, Raul Cachau, Catherine Z Chen, Kevin John Butay, Zhijian Duan, Dan Li, Hua Ren, Tianyuzhou Liang, Jianghai Zhu, Venkata P Dandey, Negin P Martin, Dominic Esposito, Uriel Ortega-Rodriguez, Miao Xu, Mario J Borgnia, Hang Xie, Mitchell Ho

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35476528

Doi: 10.1073/pnas.2201433119

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Specification of CNS macrophage subsets occurs postnatally in defined niches

Authors: Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernández-Klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto Tsuda, Claudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-Peter Knobeloch, Tim Lämmermann, Josef Priller, Katrin Kierdorf, Marco Prinz

Journal: Nature

PubMed ID: 35444273

Doi: 10.1038/s41586-022-04596-2

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Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions

Authors: Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A Stashko, Kenneth H Pearce, Stephen B Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang

Journal: J Med Chem

PubMed ID: 35467861

Doi: 10.1021/acs.jmedchem.2c00220

Products & Services: Mammalian Expression

The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain

Authors: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri

Journal: Biomolecules

PubMed ID: 35625560

Doi: 10.3390/biom12050633

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Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes

Authors: Colin J Raposo, Judith D Cserny, Gloria Serena, Jonathan N Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, Shinu John

Journal: Front Immunol

PubMed ID: 35444659

Doi: 10.3389/fimmu.2022.869669

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Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature

Authors: Congyue A Peng, Sophie Altamirano, Namrata Paladugu, Logan P Crowe, Inas F Aboobakar, Srikripa Chandrasekaran, Lukasz Kozubowski

Journal: Fungal Genet Biol

PubMed ID: 35472450

Doi: 10.1016/j.fgb.2022.103697

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Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

Authors: Beomki Lee, Jae-Hoon Ko, Jiho Park, Hee-Won Moon, Jin Yang Baek, Sunhee Jung, Hee-Young Lim, Kyung-Chang Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Hee Jae Huh, Chi Ryang Chung, Yae-Jean Kim, Eun-Jeong Joo, Eun-Suk Kang, Kyong Ran Peck

Journal: Front Cell Infect Microbiol

PubMed ID: 35493733

Doi: 10.3389/fcimb.2022.822599

Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"

Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang

Journal: ACS Omega

PubMed ID: 35465124

Doi: 10.1021/acsomega.2c01716

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Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar

Journal: Microbiologyopen

PubMed ID: 35478283

Doi: 10.1002/mbo3.1270

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NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer

Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi

Journal: Life Sci

PubMed ID: 35378140

Doi: 10.1016/j.lfs.2022.120523

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Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel

Journal: Data Brief

PubMed ID: 35516001

Doi: 10.1016/j.dib.2022.108206

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CCPG1 involved in corneal infection

Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

Journal: Int J Ophthalmol

PubMed ID: 35450172

Doi: 10.18240/ijo.2022.04.03

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Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast

Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien

Journal: Int J Mol Sci

PubMed ID: 35409414

Doi: 10.3390/ijms23074054

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LPS Response Is Impaired by Urban Fine Particulate Matter

Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva

Journal: Int J Mol Sci

PubMed ID: 35409273

Doi: 10.3390/ijms23073913

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Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung

Journal: Int J Mol Sci

PubMed ID: 35563411

Doi: 10.3390/ijms23095020

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BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of pv

Authors: Xiu-Qi Tian, Yao Wu, Zhen Cai, Wei Qian

Journal: Appl Environ Microbiol

PubMed ID: 35369702

Doi: 10.1128/aem.00031-22

Products & Services: Recombinant Proteins

Restoration of Sarco/Endoplasmic Reticulum Ca-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca Depletion

Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin

Journal: Front Pharmacol

PubMed ID: 35517826

Doi: 10.3389/fphar.2022.877175

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Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Authors: Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Alessandro Laio, Pilar Cossio

Journal: Front Immunol

PubMed ID: 35572587

Doi: 10.3389/fimmu.2022.862851

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A conserved module regulates receptor kinase signalling in immunity and development

Authors: Thomas A DeFalco, Pauline Anne, Sean R James, Andrew C Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L H Menke, Cyril Zipfel, Christian S Hardtke, Zachary L Nimchuk

Journal: Nat Plants

PubMed ID: 35422079

Doi: 10.1038/s41477-022-01134-w

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Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

Authors: Nathan L Absalom, Vivian W Y Liao, Katrine M H Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S Møller, Philip K Ahring

Journal: Nat Commun

PubMed ID: 35383156

Doi: 10.1038/s41467-022-29280-x

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Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi

Authors: Yujie Yuan, Shu Cheng, Guangkai Bian, Pan Yan, Zhengning Ma, Wen Dai, Rong Chen, Shuai Fu, Huiwen Huang, Haoming Chi, Yousheng Cai, Zixin Deng & Tiangang Liu

Journal: Nature Catalysis

Doi: 10.1038/s41929-022-00762-x

Products & Services: Plasmid DNA Preparation

Indirubin-3’-monoxime acts as proteasome inhibitor:Therapeutic application in multiple myeloma

Authors: Zhen Yu , Xiaojing Wei , Lanting Liu , Hao Sun , Teng Fang , Lu Wang , Ying Li , Weiwei Sui , Kefei Wang , Yi He , Yaozhong Zhao , Wenyang Huang , Gang An , Fancui Meng , Changjiang Huang , Tengteng Yu , Kenneth C Anderson , Tao Cheng , Lugui Qiu , Mu Hao

Journal: EBioMedicine

PubMed ID: 35344764

Doi: 10.1016/j.ebiom.2022.103950

Products & Services: Protein and Antibody Isolation

Multifunctional polyphenol-based silk hydrogel alleviate soxidative stress and enhances endogenous regeneration of osteochondral defects.

Authors: Wei Zhang 1 2 3, Yanan Zhang 1, Xiaolong Li 1, Zhicheng Cao 1 4, Qingyun Mo 1, Renwang Sheng 1, Chen Ling 1 4, Jiayu Chi 1, Qingqiang Yao 4 3, Jialin Chen 1 2 3, Hongmei Wang 1

Journal: Mater Today Bio

PubMed ID: 35469254

Doi: 10.1016/j.mtbio.2022.100251

Products & Services: Recombinant Proteins

A polyesterase from the Antarctic bacterium Moraxella sp degrades highly crystalline synthetic polymers

Authors: Efstratios Nikolaivits, George Taxeidis, Christina Gkountela, Stamatina Vouyiouka, Veselin Maslak, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: J Hazard Mater

PubMed ID: 35452981

Doi: 10.1016/j.jhazmat.2022.128900

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SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Authors: Anastasia A Minervina, Mikhail V Pogorelyy, Allison M Kirk, Jeremy Chase Crawford, E Kaitlynn Allen, Ching-Heng Chou, Robert C Mettelman, Kim J Allison, Chun-Yang Lin, David C Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R Olsen, Stacey Schultz-Cherry, Jeremie H Estepp, Maureen A McGargill, Joshua Wolf, Paul G Thomas

Journal: Nat Immunol

PubMed ID: 35383307

Doi: 10.1038/s41590-022-01184-4

Products & Services: Gene Fragments

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry

Authors: Tanaya Bagga, Nikhil Kumar Tulsian, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Cell Mol Life Sci

PubMed ID: 35397701

Doi: 10.1007/s00018-022-04245-x

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Impaired Humoral Immunity with Concomitant Preserved T Cell Reactivity in IBD Patients on Treatment with Infliximab 6 Month after Vaccination with the SARS-CoV-2 mRNA Vaccine BNT162b2: A Pilot Study

Authors: Richard Vollenberg, Phil-Robin Tepasse, Eva Lorentzen, Tobias Max Nowacki

Journal: J Pers Med

PubMed ID: 35629116

Doi: 10.3390/jpm12050694

A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz

Journal: J Immunol

PubMed ID: 35418467

Doi: 10.4049/jimmunol.2100790

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Structural insight into UV-B-activated UVR8 bound to COP1

Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin

Journal: Sci Adv

PubMed ID: 35442727

Doi: 10.1126/sciadv.abn3337

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Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine

Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic

Journal: Clin Transl Immunology

PubMed ID: 35505864

Doi: 10.1002/cti2.1391

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Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways

Authors: Jingni He, Ying Zhang, Baiyu Yao, Lidong Wang, Zhong Tian

Journal: Mol Cell Endocrinol

PubMed ID: 35390449

Doi: 10.1016/j.mce.2022.111639

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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions

Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin

Journal: Chem Sci

PubMed ID: 35655557

Doi: 10.1039/d2sc00676f

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Peptide of Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells

Authors: Pichet Ruenchit, Onrapak Reamtong, Ladawan Khowawisetsut, Poom Adisakwattana, Monrat Chulanetra, Kasem Kulkeaw, Wanpen Chaicumpa

Journal: Front Cell Infect Microbiol

PubMed ID: 35558100

Doi: 10.3389/fcimb.2022.882608

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Gene Expression in a Humanized 21-Hydroxylase Mouse Model Does Not Affect Adrenocortical Morphology and Function

Authors: Tina Schubert, Nicole Reisch, Ronald Naumann, Ilka Reichardt, Dana Landgraf, Friederike Quitter, Shamini Ramkumar Thirumalasetty, Anne-Kristin Heninger, Mihail Sarov, Mirko Peitzsch, Angela Huebner, Katrin Koehler

Journal: J Endocr Soc

PubMed ID: 35592511

Doi: 10.1210/jendso/bvac062

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Melatonin Mediated Differential Regulation of Drought Tolerance in Sensitive and Tolerant Varieties of Upland Cotton (

Authors: Laha Supriya, Pullaiahgari Durgeshwar, Mehanathan Muthamilarasan, Gudipalli Padmaja

Journal: Front Plant Sci

PubMed ID: 35444676

Doi: 10.3389/fpls.2022.821353

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Nutrient sensitive protein -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Authors: Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

Journal: Life Sci Alliance

PubMed ID: 35470239

Doi: 10.26508/lsa.202201385

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Alternative splicing of an exitron determines the subnuclear localization of the Arabidopsis DNA glycosylase MBD4L under heat stress

Authors: Nicolás Miguel Cecchini , José Roberto Torres , Ignacio Lescano López, Santiago Cobo, Florencia Nota, María Elena Alvarez

Journal: Plant J

PubMed ID: 35061303

Doi: 10.1111/tpj.15675

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Mechanism of RNA polymerase I selection by transcription factor UAF

Authors: Florence Baudin, Brice Murciano, Herman K H Fung, Simon A Fromm, Simone Mattei, Julia Mahamid, Christoph W Müller

Journal: Sci Adv

PubMed ID: 35442737

Doi: 10.1126/sciadv.abn5725

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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Authors: Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan

Journal: Nat Commun

PubMed ID: 35413950

Doi: 10.1038/s41467-022-29552-6

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A Novel Homozygous Variant Leading to Type-1 Familial Glucocorticoid Deficiency

Authors: Idris Mohammed, Basma Haris, Khalid Hussain

Journal: J Endocr Soc

PubMed ID: 35506146

Doi: 10.1210/jendso/bvac058

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Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Authors: Chongzhao You , Yumu Zhang , Peiyu Xu , Sijie Huang , Wanchao Yin, H Eric Xu , Yi Jiang

Journal: Nat Commun

PubMed ID: 35440625

Doi: 10.1038/s41467-022-29683-w

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Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the Mutant Susceptibility for Lead Compound Development

Authors: Robert J Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R Wiedman

Journal: Microbiol Spectr

PubMed ID: 35377230

Doi: 10.1128/spectrum.00439-22

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The C-Terminal Transmembrane Domain of Cowpea Mild Mottle Virus TGBp2 Is Critical for Plasmodesmata Localization and for Its Interaction With TGBp1 and TGBp3

Authors: Chong Jiang, Shiqi Shan, Yue Huang, Chenyang Mao, Hehong Zhang, Yanjun Li, Jianping Chen, Zhongyan Wei, Zongtao Sun

Journal: Front Microbiol

PubMed ID: 35495691

Doi: 10.3389/fmicb.2022.860695

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The structure of Phocaeicola vulgatus sialic acid acetylesterase

Authors: Hannah Scott, Gideon J Davies, Zachary Armstrong

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503212

Doi: 10.1107/S2059798322003357

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N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Authors: Feng Jiang, Jiawei Shen, Jiaxuan Cheng, Xia Wang, Jianguo Yang, Ningning Li, Ning Gao, Qi Jin

Journal: Sci Adv

PubMed ID: 35486720

Doi: 10.1126/sciadv.abm2343

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Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Authors: Fanfan Shu, Yu Li, Wenlun Chu, Xuehua Chen, Ziding Zhang, Yaqiong Guo, Yaoyu Feng, Lihua Xiao, Na Li

Journal: Front Microbiol

PubMed ID: 35558125

Doi: 10.3389/fmicb.2022.883674

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The Copper Resistome of Group B Streptococcus Reveals Insight into the Genetic Basis of Cellular Survival during Metal Ion Stress

Authors: Kelvin G K Goh, Matthew J Sullivan, Glen C Ulett

Journal: J Bacteriol

PubMed ID: 35404113

Doi: 10.1128/jb.00068-22

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Family 1 Glycosyltransferase UGT706F8 from Selectively Catalyzes the Synthesis of Silibinin 7--β-d-Glucoside

Authors: Gonzalo N Bidart, Natalia Putkaradze, Folmer Fredslund, Christian Kjeldsen, Ander Garralda Ruiz, Jens Ø Duus, David Teze, Ditte H Welner

Journal: ACS Sustain Chem Eng

PubMed ID: 35493695

Doi: 10.1021/acssuschemeng.1c07593

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Novel insight into the transformation of peptides and potential benefits in brown fermented goat milk by mesoporous magnetic dispersive solid phase extraction-based peptidomics

Authors: Wei Jia, An Du, Zibian Fan, Lin Shi

Journal: Food Chem

PubMed ID: 35504074

Doi: 10.1016/j.foodchem.2022.133110

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-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone

Authors: Océane Tournière, James M Gahan, Henriette Busengdal, Natascha Bartsch, Fabian Rentzsch

Journal: Sci Adv

PubMed ID: 35442742

Doi: 10.1126/sciadv.abi7109

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Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis

Authors: Inés Abatedaga, Bárbara Perez Mora, Marisel Tuttobene, Gabriela Müller, Daiana Biancotti, Claudio D Borsarelli, Lorena Valle, Maria A Mussi

Journal: PLoS ONE

PubMed ID: 35442978

Doi: 10.1371/journal.pone.0254291

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The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Authors: Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang

Journal: Cell Death Dis

PubMed ID: 35440106

Doi: 10.1038/s41419-022-04832-7

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Immunization With Recombinant Y75B8A8 Partially Protects Local Crossbred Female Goats From Infection

Authors: Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li

Journal: Front Vet Sci

PubMed ID: 35445096

Doi: 10.3389/fvets.2022.765700

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Development of an Indirect ELISA Kit for Rapid Detection of Varicella-Zoster Virus Antibody by Glycoprotein E

Authors: Yan Niu, Aiping Wang, Jingming Zhou, Hongliang Liu, Yumei Chen, Peiyang Ding, Yanhua Qi, Chao Liang, Xifang Zhu, Gaiping Zhang

Journal: Front Microbiol

PubMed ID: 35572642

Doi: 10.3389/fmicb.2022.897752

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Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists

Authors: Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen, Qing Lin

Journal: ACS Chem Biol

PubMed ID: 35417146

Doi: 10.1021/acschembio.2c00175

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Suppression of lysosomal-associated protein transmembrane 5 ameliorates cardiac function and inflammatory response by inhibiting the nuclear factor-kappa B (NF-κB) pathway after myocardial infarction in mice

Authors: Zhanchun Song, Xiaozeng Wang, Lianqi He, Liang Chen, Zhichao Ren, Siyu Song

Journal: Exp Anim

PubMed ID: 35491099

Doi: 10.1538/expanim.22-0008

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is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment

Authors: Jieung Baek, Paola A Lopez, Sangmin Lee, Taek-Soo Kim, Sanjay Kumar, David V Schaffer

Journal: Sci Adv

PubMed ID: 35427160

Doi: 10.1126/sciadv.abm4646

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A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility

Authors: Nonlawat Boonyalai, Kirakarn Kirativanich, Chatchadaporn Thamnurak, Chantida Praditpol, Brian A Vesely, Mariusz Wojnarski, John S Griesenbeck, Norman C Waters

Journal: Malar J

PubMed ID: 35459163

Doi: 10.1186/s12936-022-04148-z

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MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

Authors: Jorvani Cruz Villarreal, Rory Kruithoff, Ana Egatz-Gomez, Paul D Coleman, Robert Ros, Todd R Sandrin, Alexandra Ros

Journal: Anal Bioanal Chem

PubMed ID: 35385983

Doi: 10.1007/s00216-022-04038-y

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Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice

Authors: Chunjie Wei, Hao Liu, Wenwen Wang, Pengyu Luo, Qiuling Chen, Rou Li, Chong Wang, José Ramón Botella, Hui Zhang

Journal: Front Plant Sci

PubMed ID: 35548314

Doi: 10.3389/fpls.2022.865848

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Artemether inhibits proliferation, invasion and migration of hepatocellular carcinoma cells via targeting of CYP2J2

Authors: Xionglin Zhu, Mei Yang, Zhiling Song, Guangbing Yao, Qifeng Shi

Journal: Oncol Lett

PubMed ID: 35464300

Doi: 10.3892/ol.2022.13300

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Hypericin nanoparticles for self-illuminated photodynamic cytotoxicity based on bioluminescence resonance energy transfer

Authors: Hao-Han Yu, Qiu-Ping Deng, Qing-Hua Zheng, Yi Wang, Jian Shen, Jia-Hong Zhou

Journal: Int J Pharm

PubMed ID: 35427744

Doi: 10.1016/j.ijpharm.2022.121738

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Secretes Small RNA to Target Host and Retard Plant Floral Transition During Infection

Authors: Bo-Sen Zhang, Ying-Chao Li, Hui-Shan Guo, Jian-Hua Zhao

Journal: Front Plant Sci

PubMed ID: 35519822

Doi: 10.3389/fpls.2022.847086

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Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng

Journal: Nat Commun

PubMed ID: 35411005

Doi: 10.1038/s41467-022-29581-1

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Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

Authors: John J Wright, Olivier Biner, Injae Chung, Nils Burger, Hannah R Bridges, Judy Hirst

Journal: J Am Chem Soc

PubMed ID: 35380814

Doi: 10.1021/jacs.2c00274

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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Authors: Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B Harley, Bahram Namjou, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch, Guojun Hou, Nan Shen

Journal: Nat Commun

PubMed ID: 35388006

Doi: 10.1038/s41467-022-29514-y

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Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs

Authors: Guoping Li, Aidan C Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D Laurent, Sary F Aranki, Maria I Kontaridis, Louise C Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M Lowe, Saumya Das

Journal: Adv Sci (Weinh)

PubMed ID: 35373532

Doi: 10.1002/advs.202200829

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A Novel Multi-Epitope Edible Vaccine Candidate for Newcastle Disease Virus: Approach

Authors: Atena Mozafari, Jafar Amani, Shahla Shahsavandi, Ali Hatef Salmanian

Journal: Iran J Biotechnol

PubMed ID: 36337069

Doi: 10.30498/ijb.2022.298822.3119

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SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Authors: Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen

Journal: PLoS Biol

PubMed ID: 35417450

Doi: 10.1371/journal.pbio.3001601

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Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022

Authors: Paz Beatriz Tabilo Valenzuela, Gabriela Flores Balter, Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Catalina Moreno Calderón, Constanza Bohle Venegas, Marcia Guajardo Rivera, Francisco Silva Ojeda, Maria Jesus Vial Covarrubias

Journal: Life (Basel)

PubMed ID: 35455024

Doi: 10.3390/life12040534

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A Novel Immunochromatographic Strip Based on Latex Microspheres for the Rapid Detection of North American-Type Porcine Reproductive and Respiratory Syndrome Virus

Authors: Wansheng Li, Minhua Li, Hongliang Zhang, Chao Li, Hu Xu, Bangjun Gong, Jun Fu, Zhenyang Guo, Jinmei Peng, Guohui Zhou, Zhijun Tian, Qian Wang

Journal: Front Microbiol

PubMed ID: 35572691

Doi: 10.3389/fmicb.2022.882112

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Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma

Authors: Stacia L Koppenhafer, Kelli L Goss, Ellen Voigt, Emma Croushore, William W Terry, Jason Ostergaard, Peter M Gordon, David J Gordon

Journal: Oncogene

PubMed ID: 35422476

Doi: 10.1038/s41388-022-02310-0

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Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22

Authors: Zehua Sun, Wei Li, John W Mellors, Rimas Orentas, Dimiter S Dimitrov

Journal: Front Immunol

PubMed ID: 35464476

Doi: 10.3389/fimmu.2022.869825

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Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors

Authors: Jeppe Thorlacius-Ussing, Christina Jensen, Emilie A Madsen, Neel I Nissen, Tina Manon-Jensen, Inna M Chen, Julia S Johansen, Hadi M H Diab, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen

Journal: Int J Mol Sci

PubMed ID: 35456962

Doi: 10.3390/ijms23084144

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Multi-Omics Analysis Reveals That Synergistically Regulates SGAs and Fruit Development

Authors: Hao Guo, Mengdi Mao, Yuan Deng, Lisong Sun, Ridong Chen, Peng Cao, Jun Lai, Yueran Zhang, Chao Wang, Chun Li, Yiran Li, Qunhang Bai, Tingting Tan, Jun Yang, Shouchuang Wang

Journal: Front Plant Sci

PubMed ID: 35463452

Doi: 10.3389/fpls.2022.860577

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Dynamics of Neutralizing Antibody and T-Cell Responses to SARS-CoV-2 and Variants of Concern after Primary Immunization with CoronaVac and Booster with BNT162b2 or ChAdOx1 in Health Care Workers

Authors: Watsamon Jantarabenjakul, Pimpayao Sodsai, Napaporn Chantasrisawad, Anusara Jitsatja, Sasiprapa Ninwattana, Nattakarn Thippamom, Vichaya Ruenjaiman, Chee Wah Tan, Rakchanok Pradit, Jiratchaya Sophonphan, Supaporn Wacharapluesadee, Lin-Fa Wang, Thanyawee Puthanakit, Nattiya Hirankarn, Opass Putcharoen

Journal: Vaccines (Basel)

PubMed ID: 35632395

Doi: 10.3390/vaccines10050639

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Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Authors: Yiqi Yang , Yixuan Lin , Minqi Wang , Kai Yuan , Qishan Wang , Pei Mu , Jingke Du , Zhifeng Yu , Shengbing Yang ， Kai Huang , Yugang Wang , Hanjun Li , Tingting Tang

Journal: Bone Res

PubMed ID: 35260560

Doi: doi.org/10.1038/s41413-022-00198-w

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DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas

Authors: Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S Bhojnagarwala , Devivasha Bordoloi , Daniel H Park, Kevin Liaw, Mamadou A Bah, Paul M Lieberman , Ebony N Gary , Ami Patel , David B Weiner

Journal: Mol Ther Oncolytics

PubMed ID: 35071745

Doi: 10.1016/j.omto.2021.12.017

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RNF115 Inhibits the Post-ER Trafficking ofTLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination ofRAB1A and RAB13

Authors: Zhi-Dong Zhang , Hong-Xu Li , Hu Gan , Zhen Tang , Yu-Yao Guo , Shu-Qi Yao , Tianzi Liuyu , Bo Zhong , Dandan Lin

Journal: Adv Sci (Weinh)

PubMed ID: 35343654

Doi: doi.org/10.1002/advs.202105391

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SARS-CoV-2 variant B.1.1.7 caused HLA-A2 CD8 T cell epitope mutations for impaired cellular immune response.

Authors: Chanchan Xiao, Lipeng Mao , Zhigang Wang , Lijuan Gao , Guodong Zhu , Jun Su , Xiongfei Chen , Jun Yuan , Yutian Hu, Zhinan Yin, Jun Xie , Weiqing Ji , Haitao Niu , Feng Gao, Oscar Junhong Luo , Lianbo Xiao , Pengcheng Wang , Guobing Chen

Journal: iScience

PubMed ID: 35194575

Doi: 10.1016/j.isci.2022.103934

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Evaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2

Authors: Natalie Hofmann, Marica Grossegesse, Markus Neumann, Lars Schaade, Andreas Nitsche

Journal: Sci Rep

PubMed ID: 35241780

Doi: 10.1038/s41598-022-07597-3

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Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells

Authors: Himanshu Arora, Rehana Qureshi, Kajal Khodamoradi, Deepa Seetharam, Madhumita Parmar, Derek J Van Booven, Isabelle Catherine Issa, Robert Sackstein, Dolores Lamb, Joshua M Hare, Ranjith Ramasamy

Journal: Cell Death Dis

PubMed ID: 35246515

Doi: 10.1038/s41419-022-04658-3

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Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination

Authors: Doris Urlaub, Natalie Wolfsdorff, Jan-Erik Hoffmann, Stefanie Dorok, Markus Hoffmann, Moritz Anft, Naomi Pieris, Patrick Günther, Bernhard Schaaf, Uwe Cassens, Peter Bröde, Maren Claus, Lea K Picard, Sabine Wingert, Simone Backes, Deniz Durak, Nina Babel, Stefan Pöhlmann, Frank Renken, Stefan Raunser, Carsten Watzl

Journal: Eur J Immunol

PubMed ID: 35247269

Doi: 10.1002/eji.202149758

Development of spirulina for the manufacture and oral delivery of protein therapeutics

Authors: Benjamin W Jester, Hui Zhao, Mesfin Gewe, Thomas Adame, Lisa Perruzza, David T Bolick, Jan Agosti, Nhi Khuong, Rolf Kuestner, Caitlin Gamble, Kendra Cruickshank, Jeremy Ferrara, Rachelle Lim, Troy Paddock, Colin Brady, Stacey Ertel, Miaohua Zhang, Alex Pollock, Jamie Lee, Jian Xiong, Michael Tasch, Tracy Saveria, David Doughty, Jacob Marshall, Damian Carrieri, Lauren Goetsch, Jason Dang, Nathaniel Sanjaya, David Fletcher, Anissa Martinez, Bryce Kadis, Kristjan Sigmar, Esha Afreen, Tammy Nguyen, Amanda Randolph, Alexandria Taber, Ashley Krzeszowski, Brittney Robinett, David B Volkin, Fabio Grassi, Richard Guerrant, Ryo Takeuchi, Brian Finrow, Craig Behnke, James Roberts

Journal: Nat Biotechnol

PubMed ID: 35314813

Doi: 10.1038/s41587-022-01249-7

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Efficacy and Safety of Heterologous Booster Vaccination after Ad5-nCoV (CanSino Biologics) Vaccine: A Preliminary Descriptive Study

Authors: José Francisco Muñoz-Valle, Gabriela Athziri Sánchez-Zuno, Mónica Guadalupe Matuz-Flores, Cristian Oswaldo Hernández-Ramírez, Saúl Alberto Díaz-Pérez, Christian Johana Baños-Hernández, Francisco Javier Turrubiates-Hernández, Alejandra Natali Vega-Magaña, Jorge Hernández-Bello

Journal: Vaccines (Basel)

PubMed ID: 35335032

Doi: 10.3390/vaccines10030400

Spectrum of Phenotypic, Genetic, and Functional Characteristics in Patients With Epilepsy With Pathogenic Variants

Authors: Niklas Schwarz, Simone Seiffert, Manuela Pendziwiat, Annika Verena Rademacher, Tobias Brünger, Ulrike B S Hedrich, Paul B Augustijn, Hartmut Baier, Allan Bayat, Francesca Bisulli, Russell J Buono, Ben Zeev Bruria, Michael G Doyle, Renzo Guerrini, Gali Heimer, Michele Iacomino, Hugh Kearney, Karl Martin Klein, Ioanna Kousiappa, Wolfram S Kunz, Holger Lerche, Laura Licchetta, Ebba Lohmann, Raffaella Minardi, Marie McDonald, Sarah Montgomery, Lejla Mulahasanovic, Renske Oegema, Barel Ortal, Savvas S Papacostas, Francesca Ragona, Tiziana Granata, Phillip S Reif, Felix Rosenow, Annick Rothschild, Paolo Scudieri, Pasquale Striano, Paolo Tinuper, George A Tanteles, Annalisa Vetro, Felix Zahnert, Ethan M Goldberg, Federico Zara, Dennis Lal, Patrick May, Hiltrud Muhle, Ingo Helbig, Yvonne Weber

Journal: Neurology

PubMed ID: 35314505

Doi: 10.1212/WNL.0000000000200660

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Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging

Authors: Laura Teodori, Marjan Omer, Anders Märcher, Mads K Skaanning, Veronica L Andersen, Jesper S Nielsen, Emil Oldenburg, Yuchen Lin, Kurt V Gothelf, Jørgen Kjems

Journal: J Biol Methods

PubMed ID: 35510035

Doi: 10.14440/jbm.2022.381

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Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

Authors: Lauren B Rodda, Peter A Morawski, Kurt B Pruner, Mitchell L Fahning, Christian A Howard, Nicholas Franko, Jennifer Logue, Julie Eggenberger, Caleb Stokes, Inah Golez, Malika Hale, Michael Gale, Helen Y Chu, Daniel J Campbell, Marion Pepper

Journal: Cell

PubMed ID: 35413241

Doi: 10.1016/j.cell.2022.03.018

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Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Authors: Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Xu-Jie Zhang

Journal: Front Immunol

PubMed ID: 35386704

Doi: 10.3389/fimmu.2022.873982

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Therapeutic Effect of Melittin-dKLA Targeting Tumor-Associated Macrophages in Melanoma

Authors: Ik-Hwan Han, Chanmi Jeong, Juwon Yang, Seung-Hyeok Park, Deok-Sang Hwang, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35328518

Doi: 10.3390/ijms23063094

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Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling

Authors: Kim van Kuijk, Jasper A F Demandt, Javier Perales-Patón, Thomas L Theelen, Christoph Kuppe, Elke Marsch, Jenny de Bruijn, Han Jin, Marion J Gijbels, Ljubica Matic, Barend M E Mees, Chris P M Reutelingsperger, Ulf Hedin, Erik A L Biessen, Peter Carmeliet, Andrew H Baker, Rafael K Kramann, Leon J Schurgers, Julio Saez-Rodriguez, Judith C Sluimer

Journal: Cardiovasc Res

PubMed ID: 33913468

Doi: 10.1093/cvr/cvab152

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