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DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation

Authors: Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li

Journal: Biochem Biophys Res Commun

PubMed ID: 35533489

Doi: 10.1016/j.bbrc.2022.04.129

Products & Services: Mammalian Expression

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Authors: Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand

Journal: Nat Biomed Eng

PubMed ID: 35379957

Doi: 10.1038/s41551-022-00875-5

Products & Services: PCR Cloning and Subcloning

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran

Journal: Cancer Cell

PubMed ID: 35413272

Doi: 10.1016/j.ccell.2022.03.005

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QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®

Authors: Morteza Jaffar-Aghaei, Farzad Khanipour, Amir Maghsoudi, Rahim Sarvestani, Mahdi Mohammadian, Maryam Maleki, Forugh Havasi, Hossein Rahmani, Amir-Hossein Karagah, Mohammad-Reza Kazemali

Journal: Eur J Pharm Sci

PubMed ID: 35378209

Doi: 10.1016/j.ejps.2022.106171

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A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

Products & Services: Mammalian Expression

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

Authors: Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini

Journal: Int J Mol Sci

PubMed ID: 35563348

Doi: 10.3390/ijms23094961

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Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in

Authors: Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin

Journal: STAR Protoc

PubMed ID: 35496799

Doi: 10.1016/j.xpro.2022.101324

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Neutralization of SARS-CoV-2 Omicron sub-lineages BA1, BA11, and BA2

Authors: John P Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J Saif, Eugene M Oltz, Peter J Mohler, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 35526534

Doi: 10.1016/j.chom.2022.04.014

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Exopolysaccharides from Pantoea alhagi NX-11 specifically improve its root colonization and rice salt resistance

Authors: Liang Sun, Lifangyu Cheng, Yuhang Ma, Peng Lei, Rui Wang, Yian Gu, Sha Li, Fuhai Zhang, Hong Xu

Journal: Int J Biol Macromol

PubMed ID: 35413311

Doi: 10.1016/j.ijbiomac.2022.04.015

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Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Authors: Andrea J Parsons, Sabrina I Ophir, J Andrew Duty, Thomas A Kraus, Kathryn R Stein, Thomas M Moran, Domenico Tortorella

Journal: Commun Biol

PubMed ID: 35468974

Doi: 10.1038/s42003-022-03294-z

Products & Services: Mammalian Expression

Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2

Authors: Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani, Lara Manganaro, Matteo Conti, Renata Grifantini, Raffaele De Francesco, Cristina Nativi, Stefano Roelens

Journal: iScience

PubMed ID: 35434540

Doi: 10.1016/j.isci.2022.104239

Products & Services: Mammalian Expression

Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C

Authors: Chang Yoon Doh, Katherine L Dominic, Caitlin E Swanberg, Nikhil Bharambe, Belinda B Willard, Ling Li, Rajesh Ramachandran, Julian E Stelzer

Journal: ACS Omega

PubMed ID: 35573219

Doi: 10.1021/acsomega.2c00799

Products & Services: Mutant Libraries

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Authors: Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Journal: Cell Death Dis

PubMed ID: 35440077

Doi: 10.1038/s41419-022-04826-5

Products & Services: Recombinant Proteins

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Authors: Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin

Journal: PLoS ONE

PubMed ID: 35417479

Doi: 10.1371/journal.pone.0266143

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PINK1/Parkin-mediated mitophagy as a protective mechanism against AFB-induced liver injury in mice

Authors: Qi Wang, Fubo Jia, Chen Guo, Yuping Wang, Xuliang Zhang, Yilong Cui, Miao Song, Zheng Cao, Yanfei Li

Journal: Food Chem Toxicol

PubMed ID: 35447291

Doi: 10.1016/j.fct.2022.113043

Products & Services: Protein and Antibody Isolation

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Authors: Elodie Picarda, Phillip M Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Börgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang

Journal: Sci Adv

PubMed ID: 35476450

Doi: 10.1126/sciadv.abm7012

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Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Authors: Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca

Journal: Biomolecules

PubMed ID: 35454150

Doi: 10.3390/biom12040561

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Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P falciparum Malaria

Authors: Ananya Ray, Miti Mathur, Deepak Choubey, Krishanpal Karmodiya, Namita Surolia

Journal: MBio

PubMed ID: 35420484

Doi: 10.1128/mbio.00630-22

Products & Services: Catalog Antibodies

Characterization of a universal neutralizing monoclonal antibody against Glaesserella parasuis CdtB

Authors: Qichao Chen, Huan Wang, Liang Li, Shibang Guo, Zhankui Liu, Zizhe Hu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Vet Microbiol

PubMed ID: 35640412

Doi: 10.1016/j.vetmic.2022.109446

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as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Matthew V Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R Blount, Luke Hong, Wei-Ling Tsou, Sokol V Todi

Journal: Cells

PubMed ID: 35406787

Doi: 10.3390/cells11071223

Products & Services: PCR Cloning and Subcloning

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5'-UTR

Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao

Journal: Mob DNA

PubMed ID: 35414110

Doi: 10.1186/s13100-022-00268-0

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Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

Authors: Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

Journal: Life Sci Alliance

PubMed ID: 35459736

Doi: 10.26508/lsa.202101309

Products & Services: Codon Optimization

Full-Length Transcriptome Analysis Provides New Insights Into the Diversity of Immune-Related Genes in

Authors: Yi Zhang, Mengqi Ni, Yunhui Bai, Qiao Shi, Jinbin Zheng, Zhaoxia Cui

Journal: Front Immunol

PubMed ID: 35464434

Doi: 10.3389/fimmu.2022.843347

Products & Services: Protein and Antibody Isolation

Regulation of Mannitol Metabolism in Enterococcus faecalis and Association with Toxin-Antitoxin Locus Function

Authors: Srivishnupriya Anbalagan, Jessie Sadlon, Keith Weaver

Journal: J Bacteriol

PubMed ID: 35404112

Doi: 10.1128/jb.00047-22

Products & Services: Stable Cell Lines

Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Authors: Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso

Journal: Nat Commun

PubMed ID: 35484164

Doi: 10.1038/s41467-022-30068-2

Products & Services: Recombinant Proteins

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

Authors: Fatemeh Adiliaghdam, Hajera Amatullah, Sreehaas Digumarthi, Tahnee L Saunders, Raza-Ur Rahman, Lai Ping Wong, Ruslan Sadreyev, Lindsay Droit, Jean Paquette, Philippe Goyette, John D Rioux, Richard Hodin, Kathie A Mihindukulasuriya, Scott A Handley, Kate L Jeffrey

Journal: Sci Immunol

PubMed ID: 35394816

Doi: 10.1126/sciimmunol.abn6660

Products & Services: Mammalian Expression

The neural basis of heat seeking in a human-infective parasitic worm

Authors: Astra S Bryant, Felicitas Ruiz, Joon Ha Lee, Elissa A Hallem

Journal: Curr Biol

PubMed ID: 35483361

Doi: 10.1016/j.cub.2022.04.010

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Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Authors: Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S Toss, Mohammed Aleskandarany, Emiel A Janssen, Håvard Søiland, Meenakshi V Gupta, Michelle D Reid, Emad A Rakha, Ritu Aneja

Journal: Mol Cancer Res

PubMed ID: 34933912

Doi: 10.1158/1541-7786.MCR-20-0798

Products & Services: Plasmid DNA Preparation

The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments

Authors: Talyta do Nascimento Soares, Verônica Silva Valadares, Gisele Cardoso Amorim, Mayara de Mattos Lacerda de Carvalho, Marcia Berrêdo-Pinho, Fábio Ceneviva Lacerda Almeida, Paulo Mascarello Bisch, Paulo Ricardo Batista, Letícia Miranda Santos Lery

Journal: Proteins

PubMed ID: 35430767

Doi: 10.1002/prot.26344

Products & Services: PCR Cloning and Subcloning

FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P-dependent switch

Authors: Nathan R Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K Umasankar, Antoni G Wrobel, Jonathan G G Kaufman, Sally R Gray, Kun Qu, Philip R Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A G Briggs, Bernard T Kelly, David J Owen, Linton M Traub

Journal: Sci Adv

PubMed ID: 35486718

Doi: 10.1126/sciadv.abn2018

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Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Authors: Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu

Journal: JCI Insight

PubMed ID: 35290246

Doi: 10.1172/jci.insight.157597

Products & Services: Mammalian Expression

Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM

Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

Journal: Acta Pharm Sin B

PubMed ID: 35865098

Doi: 10.1016/j.apsb.2022.04.012

Products & Services: Mutant Libraries

Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease

Authors: Kai S Yang, Syuan-Ting Alex Kuo, Lauren R Blankenship, Zhi Zachary Geng, Shuhua G Li, David H Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu

Journal: Curr Res Chem Biol

PubMed ID: 35815070

Doi: 10.1016/j.crchbi.2022.100025

Products & Services: Protein and Antibody Isolation

Non-homologous End Joining-Mediated Insertional Mutagenesis Reveals a Novel Target for Enhancing Fatty Alcohols Production in

Authors: Mengxu Li, Jinlai Zhang, Qiuyan Bai, Lixia Fang, Hao Song, Yingxiu Cao

Journal: Front Microbiol

PubMed ID: 35547152

Doi: 10.3389/fmicb.2022.898884

Products & Services: Codon Optimization

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Authors: Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Xiumei Huang, Aishat Motolani, Mengyao Sun, Guanglong Jiang, Harikrishna Nakshatri, Melissa L Fishel, Steven Sun, Ahmad Safa, Rommie E Amaro, Mark R Kelley, Yunlong Liu, Zhong-Yin Zhang, Tao Lu

Journal: Genes Dis

PubMed ID: 37013054

Doi: 10.1016/j.gendis.2022.04.001

Products & Services: Protein and Antibody Isolation

Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yao Liu, Liying Wang, Shanyu Zhang, Qiang Zhu, Yuming Gu, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: ACS Nano

PubMed ID: 35394745

Doi: 10.1021/acsnano.2c01017

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A Nanopore Based Molnupiravir Sensor

Authors: Wendong Jia , Chengzhen Hu , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: ACS Sens

PubMed ID: 35427117

Doi: 10.1021/acssensors.2c00447

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USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

Authors: Shuwen Zhang , Shitao Zou , Deyao Yin , Lihong Zhao , Daniel Finley , Zhaolong Wu , Youdong Mao

Journal: Nature

PubMed ID: 35477760

Doi: 10.1038/s41586-022-04671-8

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A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models

Authors: Anurupa A Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim

Journal: Int J Mol Sci

PubMed ID: 35457082

Doi: 10.3390/ijms23084262

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Bioactive Hydrolysates from : Optimal Process and Bioactive Properties

Authors: Sara A Cunha, Ezequiel R Coscueta, Paulo Nova, Joana Laranjeira Silva, Maria Manuela Pintado

Journal: Molecules

PubMed ID: 35458702

Doi: 10.3390/molecules27082505

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A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer

Authors: Vitor M Almeida, J Patrick Loria, Sandro R Marana

Journal: PLoS ONE

PubMed ID: 35452497

Doi: 10.1371/journal.pone.0267536

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Silencing of Chitin-Binding Protein with PYPV-Rich Domain Impairs Cuticle and Wing Development in the Asian Citrus Psyllid,

Authors: Haizhong Yu, Long Yi, Zhanjun Lu

Journal: Insects

PubMed ID: 35447795

Doi: 10.3390/insects13040353

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The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption

Authors: Sachin Wani, Anna Daroszewska, Donald M Salter, Rob J van 't Hof, Stuart H Ralston, Omar M E Albagha

Journal: Dis Model Mech

PubMed ID: 35229101

Doi: 10.1242/dmm.049318

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Recombinant human N-acetylneuraminate lyase as a tool to study clinically relevant mutant variants

Authors: Cheng Cheng, Zi-Xuan Hu, Meng He, Li Liu, Josef Voglmeir

Journal: Carbohydr Res

PubMed ID: 35487178

Doi: 10.1016/j.carres.2022.108561

Products & Services: Mammalian Expression

Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells

Authors: Hideki Izumi, Yuanyuan Li, Michio Yasunami, Seiji Sato, Takao Mae, Yasuhiko Kaneko, Akira Nakagawara

Journal: Stem Cells

PubMed ID: 35284915

Doi: 10.1093/stmcls/sxac007

Products & Services: DNA Sequencing

Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate

Authors: Bárbara Fernandes, Rute Castro, Farien Bhoelan, Denzel Bemelman, Ricardo A Gomes, Júlia Costa, Patrícia Gomes-Alves, Toon Stegmann, Mario Amacker, Paula M Alves, Sylvain Fleury, António Roldão

Journal: Pharmaceutics

PubMed ID: 35456687

Doi: 10.3390/pharmaceutics14040854

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G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2

Authors: Wei Xu, Frank Bearoff, Sandhya Kortagere

Journal: Pharmacol Res

PubMed ID: 35429668

Doi: 10.1016/j.phrs.2022.106223

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CLEVER assay: A visual and rapid RNA extraction-free detection of SARS-CoV-2 based on CRISPR-Cas integrated RT-LAMP technology

Authors: Akansha Bhatt, Zeeshan Fatima, Munindra Ruwali, Chitra Seetharam Misra, Shyam Sunder Rangu, Devashish Rath, Ashok Rattan, Saif Hameed

Journal: J Appl Microbiol

PubMed ID: 35396760

Doi: 10.1111/jam.15571

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Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

Authors: Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii

Journal: Int J Mol Sci

PubMed ID: 35563117

Doi: 10.3390/ijms23094726

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Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity

Authors: Shaolei Xiong, Wei Wang, Alexander Kenzior, Luke Olsen, Jaya Krishnan, Jenna Persons, Kyle Medley, Robert Peuß, Yongfu Wang, Shiyuan Chen, Ning Zhang, Nancy Thomas, John M Miles, Alejandro Sánchez Alvarado, Nicolas Rohner

Journal: Curr Biol

PubMed ID: 35390280

Doi: 10.1016/j.cub.2022.03.038

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Expression of the K74 Killer Toxin from Saccharomyces paradoxus Is Modulated by the Toxin-Encoding M74 Double-Stranded RNA 5' Untranslated Terminal Region

Authors: Nieves Rodriguez-Cousiño, Pilar Gómez, Rosa Esteban

Journal: Appl Environ Microbiol

PubMed ID: 35389250

Doi: 10.1128/aem.02030-21

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A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells

Authors: Yumei Li, Lingjun Wu, Yueying Liu, Siwen Ma, Biyi Huang, Xianjing Feng, Hui Wang

Journal: Transl Oncol

PubMed ID: 35477065

Doi: 10.1016/j.tranon.2022.101424

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The Model for Mucolipidosis Type IV

Authors: Claire Y Allan, Paul R Fisher

Journal: Front Cell Dev Biol

PubMed ID: 35493081

Doi: 10.3389/fcell.2022.741967

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Role of Chitinase-3-like Protein 1 in Cardioprotection and Angiogenesis by Post-Infarction Exercise Training

Authors: Zhuo Li, Fangnan Wu, Lei Xi, Zhenjun Tian

Journal: Biomedicines

PubMed ID: 35625766

Doi: 10.3390/biomedicines10051028

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CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia

Authors: Kai Wang, Shiyue Sun, Guigui Zhang, Zixian Lu, Hui Chen, Xia Fan, Chunjie Gu, Xiaohong Pan, Qian Lin, Oscar Chen, Lu Cai, Xiaozhen Dai, Xiao Wang, Chaosheng Lu, Xiaoqing Yan, Yi Tan

Journal: Cardiovasc Drugs Ther

PubMed ID: 35471717

Doi: 10.1007/s10557-022-07337-9

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Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Authors: Caridad Miró-Pina, Olivia Charmant, Takayuki Kawaguchi, Daniel Holoch, Audrey Michaud, Isadora Cohen, Adeline Humbert, Yan Jaszczyszyn, Guillaume Chevreux, Laurence Del Maestro, Slimane Ait-Si-Ali, Olivier Arnaiz, Raphaël Margueron, Sandra Duharcourt

Journal: Dev Cell

PubMed ID: 35429435

Doi: 10.1016/j.devcel.2022.03.014

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A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers

Authors: Ken-Ichi Hanada, Chihao Zhao, Raul Gil-Hoyos, Jared J Gartner, Christopher Chow-Parmer, Frank J Lowery, Sri Krishna, Todd D Prickett, Scott Kivitz, Maria R Parkhurst, Nathan Wong, Zachary Rae, Michael C Kelly, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg, James C Yang

Journal: Cancer Cell

PubMed ID: 35452604

Doi: 10.1016/j.ccell.2022.03.012

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OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer

Authors: Fatemeh Yousefi, Hadi Najafi, Mehrdad Behmanesh, Bahram M Soltani

Journal: Mol Biol Rep

PubMed ID: 35397713

Doi: 10.1007/s11033-021-07110-5

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Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Authors: Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 35380812

Doi: 10.1021/acs.jafc.1c08262

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Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Authors: Kareem A Heslop, Pieter Burger, Christiana Kappler, Ashish K Solanki, Monika Gooz, Yuri K Peterson, Catherine Mills, Thomas Benton, Stephen A Duncan, Patrick M Woster, Eduardo N Maldonado

Journal: Biomed Pharmacother

PubMed ID: 35447542

Doi: 10.1016/j.biopha.2022.112928

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The development of a candidate of desensitization vaccines against Der f 2 nearly without IgE-binding activity

Authors: Xiao-Jing Ling, Chen Pan, Ling-Xiao Tan, Ying Zhu, Yu-Xing Yang, Xiao-Fei Zeng, Jin-Lyu Sun, Ji-Fu Wei, Chen Lu

Journal: Immunobiology

PubMed ID: 35580444

Doi: 10.1016/j.imbio.2022.152217

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Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis

Authors: Takafumi Kato, Giorgia Radicioni, Micah J Papanikolas, Georgi V Stoychev, Matthew R Markovetz, Kazuhiro Aoki, Melody Porterfield, Kenichi Okuda, Selene M Barbosa Cardenas, Rodney C Gilmore, Cameron B Morrison, Camille Ehre, Kimberlie A Burns, Kristen K White, Tara A Brennan, Henry P Goodell, Holly Thacker, Henry T Loznev, Lawrence J Forsberg, Takahide Nagase, Michael Rubinstein, Scott H Randell, Michael Tiemeyer, David B Hill, Mehmet Kesimer, Wanda K O'Neal, Stephen T Ballard, Ronit Freeman, Brian Button, Richard C Boucher

Journal: Sci Adv

PubMed ID: 35363522

Doi: 10.1126/sciadv.abm9718

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First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine

Authors: Luis Martínez, Iker Malaina, David Salcines-Cuevas, Héctor Terán-Navarro, Andrea Zeoli, Santos Alonso, Ildefonso M De la Fuente, Elena Gonzalez-Lopez, J Gonzalo Ocejo-Vinyals, Mónica Gozalo-Margüello, Jorge Calvo-Montes, Carmen Alvarez-Dominguez

Journal: Sci Rep

PubMed ID: 35440789

Doi: 10.1038/s41598-022-09615-w

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Authors: Francisco J Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E Shepard, Santiago Rodríguez de Córdoba, M Cristina Vega

Journal: Nat Commun

PubMed ID: 35413960

Doi: 10.1038/s41467-022-29580-2

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Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract

Authors: Drishya Kurup, Christoph Wirblich, Rachael Lambert, Leila Zabihi Diba, Benjamin E Leiby, Matthias J Schnell

Journal: npj Vaccines

PubMed ID: 35440656

Doi: 10.1038/s41541-022-00464-2

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Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

Authors: Johannes Gubat, Karthik Selvaraju, Linda Sjöstrand, Dhananjay Kumar Singh, Maria V Turkina, Bernhard Schmierer, Pierre Sabatier, Roman A Zubarev, Stig Linder, Pádraig D'Arcy

Journal: Front Oncol

PubMed ID: 35530310

Doi: 10.3389/fonc.2022.852980

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Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

Authors: Matthew P Ostrowski, Sabina Leanti La Rosa, Benoit J Kunath, Andrew Robertson, Gabriel Pereira, Live H Hagen, Neha J Varghese, Ling Qiu, Tianming Yao, Gabrielle Flint, James Li, Sean P McDonald, Duna Buttner, Nicholas A Pudlo, Matthew K Schnizlein, Vincent B Young, Harry Brumer, Thomas M Schmidt, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Bruce Hamaker, Emiley A Eloe-Fadrosh, Ashootosh Tripathi, Phillip B Pope, Eric C Martens

Journal: Nat Microbiol

PubMed ID: 35365790

Doi: 10.1038/s41564-022-01093-0

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Combination of resolvin E1 and lipoxin A4 promotes the resolution of pulpitis by inhibiting NF-κB activation through upregulating sirtuin 7 in dental pulp fibroblasts

Authors: Xiaochen Liu, Chunmeng Wang, Liping Pang, Liangliang Pan, Qi Zhang

Journal: Cell Prolif

PubMed ID: 35411569

Doi: 10.1111/cpr.13227

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Rapid and sensitive detection of African swine fever virus in pork using recombinase aided amplification combined with QDMs-based test strip

Authors: Xiaoyun Wen, Qingyun Xie, Jiahao Li, Yanrui Pei, Yun Bai, Fei Liu, Haiying Cui, Guoqing Shao, Zhixin Feng

Journal: Anal Bioanal Chem

PubMed ID: 35380231

Doi: 10.1007/s00216-022-04030-6

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Efficacy of convalescent plasma therapy in the patient with COVID-19: a randomised control trial (COPLA-II trial)

Authors: Meenu Bajpai, Ashish Maheshwari, Vikas Dogra, Suresh Kumar, Ekta Gupta, Pratibha Kale, Vandana Saluja, Sherin S Thomas, Nirupama Trehanpati, Chhagan Bihari, Reshu Agarwal, Praveen Bharti, Prabha Shankar, Javid Hussain, Karan Chhabra, Amita Gupta, Ashad Narayanan, Sarika Agarwal, Shruti Jain, Ankit Bhardwaj, Guresh Kumar, Birendra Kumar Yadav, Shiv Kumar Sarin

Journal: BMJ Open

PubMed ID: 35387813

Doi: 10.1136/bmjopen-2021-055189

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Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning

Authors: Michael R Schamber , Reza Vafabakhsh

Journal: Nat Commun

PubMed ID: 35459864

Doi: 10.1038/s41467-022-29897-y

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Coenzyme B 12 -dependent and independent photoregulation of carotenogenesis across Myxococcales

Authors: Ricardo Pérez-Castaño , Eva Bastida-Martínez , Jesús Fernández-Zapata , María Del Carmen Polanco , María Luisa Galbis-Martínez , Antonio A Iniesta , Marta Fontes , S Padmanabhan , Montserrat Elías-Arnanz

Journal: Environ Microbiol

PubMed ID: 35005822

Doi: 10.1111/1462-2920.15895

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Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia

Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498405

Doi: 10.3389/fendo.2022.863940

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Blocking TGF- Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

Authors: Yifei Fang, Xiyao Li, Yuxuan Jiang, Zhihan Ge

Journal: J Oncol

PubMed ID: 35498537

Doi: 10.1155/2022/3447185

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β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Authors: Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen

Journal: Behav Brain Res

PubMed ID: 35398487

Doi: 10.1016/j.bbr.2022.113888

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CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Authors: Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu

Journal: Nat Biotechnol

PubMed ID: 35379961

Doi: 10.1038/s41587-022-01256-8

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PPARγ phase separates with RXRα at PPREs to regulate target gene expression

Authors: Zhean Li, Lingling Luo, Wenxia Yu, Ping Li, Danfeng Ou, Jia Liu, Hanhui Ma, Qinhu Sun, Aibin Liang, Cheng Huang, Tian Chi, Xingxu Huang, Yu Zhang

Journal: Cell Discov

PubMed ID: 35473936

Doi: 10.1038/s41421-022-00388-0

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Identification of Potential Peptide Marker(s) for Evaluating Pork Meat Freshness via Mass Spectrometry-Based Peptidomics during Storage under Different Temperatures

Authors: Zhenqian Wei, Chen Dai, Anthony P Bassey, Changbo Tang, Yu Han, Chong Wang, Guanghong Zhou

Journal: Foods

PubMed ID: 35454731

Doi: 10.3390/foods11081144

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Exploration of Pyrrolysyl-tRNA Synthetase Activity in Yeast

Authors: Jessica T Stieglitz, Priyanka Lahiri, Matthew I Stout, James A Van Deventer

Journal: ACS Synth Biol

PubMed ID: 35417129

Doi: 10.1021/acssynbio.2c00001

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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35440653

Doi: 10.1038/s41522-022-00285-0

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Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation

Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Journal: J Phys Chem B

PubMed ID: 35388695

Doi: 10.1021/acs.jpcb.1c10966

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MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2

Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury

Journal: Life Sci

PubMed ID: 35504332

Doi: 10.1016/j.lfs.2022.120592

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A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis

Authors: Casper Wilkens, Marlene Vuillemin, Bo Pilgaard, Igor Polikarpov, Jens Preben Morth

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35503213

Doi: 10.1107/S2059798322003527

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Premetazoan Origin of Neuropeptide Signaling

Authors: Luis Alfonso Yañez-Guerra, Daniel Thiel, Gáspár Jékely

Journal: Mol Biol Evol

PubMed ID: 35277960

Doi: 10.1093/molbev/msac051

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Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs

Authors: Helena Tossavainen, Hasan Uğurlu, Mikael Karjalainen, Maarit Hellman, Lina Antenucci, Riku Fagerlund, Kalle Saksela, Perttu Permi

Journal: Structure

PubMed ID: 35390274

Doi: 10.1016/j.str.2022.03.006

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Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response

Authors: Sammy Patyna, Timon Eckes, Benjamin F Koch, Stephan Sudowe, Anke Oftring, Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Despina Avaniadi, Rahel Steiner, Ingeborg A Hauser, Josef M Pfeilschifter, Christoph Betz

Journal: Vaccines (Basel)

PubMed ID: 35455334

Doi: 10.3390/vaccines10040585

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BRAF Modulates Lipid Use and Accumulation

Authors: Jacqueline A Turner, Emily L Paton, Robert Van Gulick, Davide Stefanoni, Francesca Cendali, Julie Reisz, Richard P Tobin, Martin McCarter, Angelo D'Alessandro, Raul M Torres, William A Robinson, Kasey L Couts, Isabel R Schlaepfer

Journal: Cancers (Basel)

PubMed ID: 35565240

Doi: 10.3390/cancers14092110

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production of pederin by labrenzin pathway expansion

Authors: Dina Kačar, Carmen Schleissner, Librada M Cañedo, Pilar Rodríguez, Fernando de la Calle, Carmen Cuevas, Beatriz Galán, José Luis García

Journal: Metab Eng Commun

PubMed ID: 35517715

Doi: 10.1016/j.mec.2022.e00198

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Real meat and plant-based meat analogues have different in vitro protein digestibility properties

Authors: Yunting Xie, Linlin Cai, Di Zhao, Hui Liu, Xinglian Xu, Guanghong Zhou, Chunbao Li

Journal: Food Chem

PubMed ID: 35413556

Doi: 10.1016/j.foodchem.2022.132917

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NADPH-Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from

Authors: Mingxuan Wang, Jing Li, Wenjie Cong, Jianguo Zhang

Journal: Curr Issues Mol Biol

PubMed ID: 35678654

Doi: 10.3390/cimb44050125

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Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow Analyzer

Authors: Andrew Cameron, Jessica L Bohrhunter, Claire A Porterfield, Rupinder Mangat, Michael H Karasick, Zachary Pearson, Stephen Angeloni, Nicole D Pecora

Journal: Microbiol Spectr

PubMed ID: 35389244

Doi: 10.1128/spectrum.02507-21

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Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody

Authors: Kristi Tsz-Wan Lai, Emilie Yuen-Ting Lai Wan Loong, Terry Ling-Hiu Fung, Luke Wing-Pan Luk, Chor-Chiu Lau, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang

Journal: Vaccines (Basel)

PubMed ID: 35455305

Doi: 10.3390/vaccines10040556

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Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147

Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana

Journal: Sci Rep

PubMed ID: 35468972

Doi: 10.1038/s41598-022-10657-3

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A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan

Journal: Nat Commun

PubMed ID: 35393441

Doi: 10.1038/s41467-022-29574-0

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pH-Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

Authors: Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, Yi Zhao, Brian S Yandell, Shaoqin Gong

Journal: Adv Mater

PubMed ID: 35119139

Doi: 10.1002/adma.202110618

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Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Typhimurium Infection in Mouse

Authors: Astrid Tuxpan-Pérez, Marco Antonio Ibarra-Valencia, Blanca Elisa Estrada, Herlinda Clement, Ligia Luz Corrales-García, Gerardo Pavel Espino-Solis, Gerardo Corzo

Journal: Antibiotics (Basel)

PubMed ID: 35625251

Doi: 10.3390/antibiotics11050607

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Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Authors: Alexander F Flynn, Rebekah T Taylor, Marzena E Pazgier, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Brynna I Gleeson, Tim K Maugel, Thomas B Nutman, Edward Mitre

Journal: MBio

PubMed ID: 35475643

Doi: 10.1128/mbio.03742-21

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Ferritin Light Chain: A Candidate Autoantigen in Immuno-Related Pancytopenia

Authors: Yang Zhang, Shanfeng Hao, Na Xiao, Yu Zhang, Huaquan Wang, Lijuan Li, Rong Fu, Zonghong Shao

Journal: Front Immunol

PubMed ID: 35572557

Doi: 10.3389/fimmu.2022.851096

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Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells

Authors: Siyu Chen, Zhiquan Liu, Hao Yu, Liangxue Lai, Zhanjun Li

Journal: J Genet Genomics

PubMed ID: 35421582

Doi: 10.1016/j.jgg.2022.03.007

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TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG

Authors: Jing Wang, Xiaotao Pan, Jie Li, Jin Zhao

Journal: Mol Med Rep

PubMed ID: 35485284

Doi: 10.3892/mmr.2022.12719

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