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Engineering a Pseudo-26-kDa Glutathione Transferase from / for Structure, Kinetics, and Ligandin Studies

Authors: Neo Padi, Blessing Oluebube Akumadu, Olga Faerch, Chinyere Aloke, Vanessa Meyer, Ikechukwu Achilonu

Journal: Biomolecules

PubMed ID: 34944488

Doi: 10.3390/biom11121844

Products & Services: PCR Cloning and Subcloning

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice NF-ĸB Activation

Authors: Jie Xia, Wenqi Tang, Jiangmei Wang, Dengming Lai, Qi Xu, Ruoqiong Huang, Yaoqin Hu, Xiaojue Gong, Jiajie Fan, Qiang Shu, Jianguo Xu

Journal: Front Immunol

PubMed ID: 34950152

Doi: 10.3389/fimmu.2021.791753

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 seroprevalence, seroconversion and neutralizing antibodies in a systemic lupus erythematosus cohort and comparison to controls

Authors: Hannah R Mathew, May Y Choi, Katherine Buhler, Xenia Gukova, Francesca S Cardwell, Heather Waldhauser, Ann E Clarke, Marvin J Fritzler

Journal: Lupus

PubMed ID: 34874781

Doi: 10.1177/09612033211063793

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Soybean miR159 Regulatory Network Involved in Gibberellin-Modulated Resistance to

Authors: Piao Lei, Nawei Qi, Yuan Zhou, Yuanyuan Wang, Xiaofeng Zhu, Yuanhu Xuan, Xiaoyu Liu, Haiyan Fan, Lijie Chen, Yuxi Duan

Journal: Int J Mol Sci

PubMed ID: 34884977

Doi: 10.3390/ijms222313172

Products & Services: Proteins, Expression, Isolation and Analysis

Expression profile of RNA binding protein in cervical cancer using bioinformatics approach

Authors: Zhiyuan Huang, Fang Li, Qinchuan Li

Journal: Cancer Cell Int

PubMed ID: 34863153

Doi: 10.1186/s12935-021-02319-7

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Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma

Authors: Caroline T Seebauer, Matthew S Graus, Lan Huang, Alex J McCann, Jill Wylie-Sears, Frank R Fontaine, Tara Karnezis, David Zurakowski, Steven J Staffa, Frédéric A Meunier, John B Mulliken, Joyce Bischoff, Mathias Francois

Journal: J Clin Invest

PubMed ID: 34874911

Doi: 10.1172/JCI151109

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RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Authors: Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, Georg Stoecklin

Journal: Nat Commun

PubMed ID: 34887419

Doi: 10.1038/s41467-021-27471-6

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HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

Authors: Benjy Jy Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono, Yorifumi Satou

Journal: J Clin Invest

PubMed ID: 34907908

Doi: 10.1172/JCI150472

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Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium

Authors: Yukiko Sato, Kamila R Mustafina, Yishan Luo, Carolina Martini, David Y Thomas, Paul W Wiseman, John W Hanrahan

Journal: Sci Rep

PubMed ID: 34853321

Doi: 10.1038/s41598-021-02420-x

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GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Authors: Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum

Journal: Nat Commun

PubMed ID: 34880217

Doi: 10.1038/s41467-021-27442-x

Products & Services: Mammalian Expression

Rice stripe virus activates the bZIP17/28 branch of the unfolded protein response signalling pathway to promote viral infection

Authors: Chenyang Li, Tianze Zhang, Yu Liu, Zongdi Li, Yaqin Wang, Shuai Fu, Yi Xu, Tong Zhou, Jianxiang Wu, Xueping Zhou

Journal: Mol Plant Pathol

PubMed ID: 34897936

Doi: 10.1111/mpp.13171

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Construction, expression, purification, characterization, and structural analysis of microbial transglutaminase variants

Authors: Xiaoping Song, Hefang Sheng, Yueqiao Zhou, Yin Yu, Yingjiao He, Zihan Wang

Journal: Biotechnol Appl Biochem

PubMed ID: 34894362

Doi: 10.1002/bab.2298

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Edaravone Improves the Post-traumatic Brain Injury Dysfunction in Learning and Memory by Modulating Nrf2/ARE Signal Pathway

Authors: Xiushan Li, Jing Yu, Dongzhou Ma, Xuehui Weng

Journal: Clinics (Sao Paulo)

PubMed ID: 34878029

Doi: 10.6061/clinics/2021/e3131

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Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus

Authors: Jiao Lan, Ke Li, Austin Gresham, Jifei Miao

Journal: Eur J Pharmacol

PubMed ID: 34896110

Doi: 10.1016/j.ejphar.2021.174693

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Seven-Month Analysis of Five SARS-CoV-2 Antibody Assay Results after ChAdOx1 nCoV-19 Vaccination: Significant Decrease in SARS-CoV-2 Antibody Titer

Authors: Seri Jeong, Nuri Lee, Su-Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun-Ju Jung, Heungjeong Woo, Yu-Bin Seo, Jin-Ju Park, Hyun-Soo Kim

Journal: Diagnostics (Basel)

PubMed ID: 35054251

Doi: 10.3390/diagnostics12010085

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Seven-Month Analysis of Five SARS-CoV-2 Antibody Assay Results after ChAdOx1 nCoV-19 Vaccination: Significant Decrease in SARS-CoV-2 Antibody Titer

Authors: Seri Jeong, Nuri Lee, Su-Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun-Ju Jung, Heungjeong Woo, Yu-Bin Seo, Jin-Ju Park, Hyun-Soo Kim

Journal: Diagnostics (Basel)

PubMed ID: 35054251

Doi: 10.3390/diagnostics12010085

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Deferasirox combination with eltrombopag shows anti-myelodysplastic syndrome effects by enhancing iron deprivation-related apoptosis

Authors: Lei Huang, Mengyue Tian, Zhaoyun Liu, Chunyan Liu, Rong Fu

Journal: J Investig Med

PubMed ID: 34921125

Doi: 10.1136/jim-2021-002147

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CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study

Authors: Yazdan Rahmati, Hasan Mollanoori, Sajad Najafi, Sajjad Esmaeili, Mohammad Reza Alivand

Journal: BMC Pediatr

PubMed ID: 34895171

Doi: 10.1186/s12887-021-03003-5

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Critical residues for proteolysis activity of maize chlorotic dwarf virus (MCDV) 3C-like protease and comparison of activity of orthologous waikavirus proteases

Authors: Lucy R Stewart, Matthew Willman, DeeMarie Marty, Anna Emmick Cole, Kristen Willie

Journal: Virology

PubMed ID: 34998226

Doi: 10.1016/j.virol.2021.12.008

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Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

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Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

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A periplasmic cupredoxin with a green CuT15 center is involved in bacterial copper tolerance

Authors: Anne Durand, Mélanie Fouesnard, Marie-Line Bourbon, Anne-Soisig Steunou, Elisabeth Lojou, Pierre Dorlet, Soufian Ouchane

Journal: Metallomics

PubMed ID: 34791351

Doi: 10.1093/mtomcs/mfab067

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miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia

Authors: Enbo Wang, Yunyan Zhang, Rongmei Ding, Xiaohua Wang, Shumin Zhang, Xinghua Li

Journal: Mol Med Rep

PubMed ID: 34821370

Doi: 10.3892/mmr.2021.12543

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Incomplete radiofrequency ablation induced chemoresistance by up-regulating heat shock protein 70 in hepatocellular carcinoma

Authors: Fuan Wang, Chuan Xu, Guiling Li, Penghua Lv, Jianping Gu

Journal: Exp Cell Res

PubMed ID: 34801560

Doi: 10.1016/j.yexcr.2021.112910

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Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor

Authors: Varsha Ashok Walvekar, Karthik Ramesh, Chacko Jobichen, Muthu Kannan, J Sivaraman, R Manjunatha Kini, Yu Keung Mok

Journal: Protein Sci

PubMed ID: 34800067

Doi: 10.1002/pro.4245

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Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Authors: Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A L Bennett, Angela M Crawley, Patrick M Giguère, Curtis Cooper, Marc-André Langlois

Journal: EBioMedicine

PubMed ID: 34861490

Doi: 10.1016/j.ebiom.2021.103700

Products & Services: Codon Optimization

The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits and Mammalian Thioredoxin Reductases by Targeting Different Residues

Authors: Ricardo Colon, Michelle Wheater, Emily J Joyce, Emma J Ste Marie, Robert J Hondal, Kathleen S Rein

Journal: J Nat Prod

PubMed ID: 34752085

Doi: 10.1021/acs.jnatprod.1c00795

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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Authors: Sophie M-C Gobeil, Benjamin G Bobay, Praveen R Juvvadi, D Christopher Cole, Joseph Heitman, William J Steinbach, Ronald A Venters, Leonard D Spicer

Journal: MBio

PubMed ID: 34809463

Doi: 10.1128/mBio.03000-21

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Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation

Authors: Anne Schreiber, Ben C Collins, Colin Davis, Radoslav I Enchev, Angie Sedra, Rocco D'Antuono, Ruedi Aebersold, Matthias Peter

Journal: Mol Cell

PubMed ID: 34798055

Doi: 10.1016/j.molcel.2021.10.024

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Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides

Authors: Xiaolong Chen, Hanjie Liu, Ang Li, Shuangshuang Ji, Hao Fei

Journal: J Biol Chem

PubMed ID: 34736897

Doi: 10.1016/j.jbc.2021.101364

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Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

Authors: Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau

Journal: EMBO J

PubMed ID: 34842295

Doi: 10.15252/embj.2021108591

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TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease

Authors: Christian B Lindstad, Alisa E Dewan, Jorunn Stamnaes, Ludvig M Sollid, M Fleur du Pré

Journal: PLoS ONE

PubMed ID: 34731200

Doi: 10.1371/journal.pone.0259082

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T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Authors: Adrienn Angyal, Stephanie Longet, Shona C Moore, Rebecca P Payne, Adam Harding, Tom Tipton, Patpong Rongkard, Mohammad Ali, Luisa M Hering, Naomi Meardon, James Austin, Rebecca Brown, Donal Skelly, Natalie Gillson, Sue L Dobson, Andrew Cross, Gurjinder Sandhar, Jonathan A Kilby, Jessica K Tyerman, Alexander R Nicols, Jarmila S Spegarova, Hema Mehta, Hailey Hornsby, Rachel Whitham, Christopher P Conlon, Katie Jeffery, Philip Goulder, John Frater, Christina Dold, Matthew Pace, Ane Ogbe, Helen Brown, M Azim Ansari, Emily Adland, Anthony Brown, Meera Chand, Adrian Shields, Philippa C Matthews, Susan Hopkins, Victoria Hall, William James, Sarah L Rowland-Jones, Paul Klenerman, Susanna Dunachie, Alex Richter, Christopher J A Duncan, Eleanor Barnes, Miles Carroll, Lance Turtle, Thushan I de Silva

Journal: Lancet Microbe

PubMed ID: 34778853

Doi: 10.1016/S2666-5247(21)00275-5

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Identification of immunogenic MHC class II human HER3 peptides that mediate anti-HER3 CD4+ Th1 responses and potential use as a cancer vaccine

Authors: Amrita Basu, Gabriella K Albert, Sabrina Awshah, Jashodeep Datta, Krithika N Kodumudi, Corey Gallen, Amber Beyer, Keiran S M Smalley, Paulo C Rodriguez, Derek R Dukett, Peter A Forsyth, Aixa Soyano, Gary K Koski, Ricardo Lima Barros Costa, Heather Han, Hatem Soliman, Marie Catherine Lee, Pawel Kalinski, Brian J Czerniecki

Journal: Cancer Immunol Res

PubMed ID: 34785506

Doi: 10.1158/2326-6066.CIR-21-0454

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Peptide-coating 2D and small chemical molecules prolong the passage of porcine spermatogonia stem cells

Authors: Ying Zhang, Camila Bruna de Lima, Zhe Zhou, Qiaoyan Shen, Zhenshuo Zhu, Jinlian Hua

Journal: Reprod Domest Anim

PubMed ID: 34748668

Doi: 10.1111/rda.14042

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Suppression of a Novel Vitellogenesis-Inhibiting Hormone Significantly Increases Ovarian Vitellogenesis in the Black Tiger Shrimp,

Authors: Phaivit Laphyai, Thanapong Kruangkum, Charoonroj Chotwiwatthanakun, Wanita Semchuchot, Prawporn Thaijongrak, Prasert Sobhon, Pei-San Tsai, Rapeepun Vanichviriyakit

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34867802

Doi: 10.3389/fendo.2021.760538

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Neoantigen Dendritic Cell Vaccination Combined with Anti-CD38 and CpG Elicits Anti-Tumor Immunity against the Immune Checkpoint Therapy-Resistant Murine Lung Cancer Cell Line LLC1

Authors: Changbo Sun, Koji Nagaoka, Yukari Kobayashi, Hidewaki Nakagawa, Kazuhiro Kakimi, Jun Nakajima

Journal: Cancers (Basel)

PubMed ID: 34771674

Doi: 10.3390/cancers13215508

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Engineering of for 24-Methylene-Cholesterol Production

Authors: Jiao Yang, Changfu Li, Yansheng Zhang

Journal: Biomolecules

PubMed ID: 34827708

Doi: 10.3390/biom11111710

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High-Throughput On-Chip Human Mesenchymal Stromal Cell Potency Prediction

Authors: Rebecca S Schneider, Alexandra C Vela, Evelyn Kendall Williams, Karen E Martin, Wilbur A Lam, Andrés J García

Journal: Adv Healthc Mater

PubMed ID: 34725948

Doi: 10.1002/adhm.202101995

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The flagellin of Vibrio parahaemolyticus induces the inflammatory response of Tetraodon nigroviridis through TLR5M

Authors: Xue Yu, Songze Gao, Jiachang Xu, Yulin Zhao, Yuyou Lu, Niuniu Deng, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Fish Shellfish Immunol

PubMed ID: 34737057

Doi: 10.1016/j.fsi.2021.10.024

Products & Services: Proteins, Expression, Isolation and Analysis

HO Functions as a Downstream Signal of IAA to Mediate HS-Induced Chilling Tolerance in Cucumber

Authors: Xiaowei Zhang, Yanyan Zhang, Chenxiao Xu, Kun Liu, Huangai Bi, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 34884713

Doi: 10.3390/ijms222312910

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sp nov, isolated from Arctic tundra soil, and emended descriptions of , and

Authors: Yongping Zhang, Xiaoya Peng, Kun Qin, Jia Liu, Qiang Xu, Jingjing Niu, Yanyan Zheng, Fang Peng

Journal: Int J Syst Evol Microbiol

PubMed ID: 34846279

Doi: 10.1099/ijsem.0.005103

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Pharmacokinetic Assessment of Rottlerin from Using a Highly Sensitive Liquid Chromatography-Tandem Mass Spectrometry-Based Bioanalytical Method

Authors: Diksha Manhas, Abhishek Gour, Nivedita Bhardwaj, Deepak K Sharma, Kuhu Sharma, Bhavna Vij, Shreyans K Jain, Gurdarshan Singh, Utpal Nandi

Journal: ACS Omega

PubMed ID: 34901612

Doi: 10.1021/acsomega.1c04266

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Geminin is essential for DNA re-replication in the silk gland cells of silkworms

Authors: Tai-Hang Liu, Xiao-Long Dong, Peng Chen, Qian Zhang, Xiao-Lin Zhou, Cheng Lu, Min-Hui Pan

Journal: Exp Cell Res

PubMed ID: 34843715

Doi: 10.1016/j.yexcr.2021.112951

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Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

Authors: Byung Chull An, Yeo-Sang Yoon, Ho Jin Park, Sangkyun Park, Tai Yeub Kim, Jun Young Ahn, Daebeom Kwon, Oksik Choi, Jin Young Heo, Yongku Ryu, Joong-Hyun Kim, Heejong Eom, Myung Jun Chung

Journal: Drug Des Devel Ther

PubMed ID: 34866901

Doi: 10.2147/DDDT.S319930

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Preparation of multiplexed control materials for cancer mutation analysis by genome editing in GM12878 cells

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jinming Li

Journal: J Clin Lab Anal

PubMed ID: 34811797

Doi: 10.1002/jcla.24139

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Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine

Authors: Yajuan Zhang, Hua Yu, Jie Zhang, Hong Gao, Siyao Wang, Shuxian Li, Ping Wei, Ji Liang, Guanzhen Yu, Xiongjun Wang, Xinxiang Li, Dawei Li, Weiwei Yang

Journal: J Clin Invest

PubMed ID: 34720086

Doi: 10.1172/JCI146187

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ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling

Authors: Beibei Wu, Arunachalam Ramaiah, Gustavo Garcia, Spyridon Hasiakos, Vaithilingaraja Arumugaswami, Sonal Srikanth

Journal: J Immunol

PubMed ID: 34819389

Doi: 10.4049/jimmunol.2100742

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Trichinella spiralis: Knockdown of gamma interferon inducible lysosomal thiol reductase (GILT) results in the reduction of worm burden

Authors: Hong Fei, Muhammad Ali-Ul-Husnain Naqvi, Sana Zahra Naqvi, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: PLoS Negl Trop Dis

PubMed ID: 34847145

Doi: 10.1371/journal.pntd.0009958

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Key carboxylate residues for iron transit through the prokaryotic ferritin Ftn

Authors: Justin M Bradley, Joshua Fair, Andrew M Hemmings, Nick E Le Brun

Journal: Microbiology (Reading)

PubMed ID: 34825885

Doi: 10.1099/mic.0.001105

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Development of a novel promoter engineering-based strategy for creating an efficient para-nitrophenol-mineralizing bacterium

Authors: Kaiyue Huo, Yujie Liu, Rui Huang, Yiting Zhang, Honglu Liu, You Che, Chao Yang

Journal: J Hazard Mater.

PubMed ID: 34753648

Doi: 10.1016/j.jhazmat.2021.127672.

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Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine : Secondary Analysis of a Randomized Trial

Authors: Deepali Kumar, Victor H Ferreira, Victoria G Hall, Queenie Hu, Reuben Samson, Terrance Ku, Matthew Ierullo, Beata Majchrzak-Kita, George Tomlinson, Anne-Claude Gingras, Atul Humar

Journal: Ann Intern Med

PubMed ID: 34807716

Doi: 10.7326/M21-3480

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Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

Authors: Mary S Morrison, Tina Wang, Aditya Raguram, Colin Hemez, David R Liu

Journal: Nat Commun

PubMed ID: 34789771

Doi: 10.1038/s41467-021-27102-0

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The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity

Authors:

Journal: JAMA

PubMed ID: 34673883

Doi: 10.1001/jama.2021.18919

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Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

Authors: Jia-Min Yan, Wen-Kang Zhang, Li-Na Yan, Yong-Jun Jiao, Chuan-Min Zhou, Xue-Jie Yu

Journal: Autophagy

PubMed ID: 34747299

Doi: 10.1080/15548627.2021.1994296

Products & Services: Proteins, Expression, Isolation and Analysis

Porcine Epidemic Diarrhea Virus Envelope Protein Blocks SLA-DR Expression in Barrow-Derived Dendritic Cells by Inhibiting Promoters Activation

Authors: Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao, Yuchen Nan, Chunyan Wu

Journal: Front Immunol

PubMed ID: 34858400

Doi: 10.3389/fimmu.2021.741425

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface

Authors: Devan Diwanji, Raphael Trenker, Tarjani M Thaker, Feng Wang, David A Agard, Kliment A Verba, Natalia Jura

Journal: Nature

PubMed ID: 34759323

Doi: 10.1038/s41586-021-04084-z

Products & Services: Proteins, Expression, Isolation and Analysis

Aggregation and the Intrinsic Structural Disorder of Dipeptide Repeat Peptides of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Characterized by NMR

Authors: Bankala Krishnarjuna, Magdalena I Ivanova, Ayyalusamy Ramamoorthy

Journal: J Phys Chem B

PubMed ID: 34751579

Doi: 10.1021/acs.jpcb.1c08149

Products & Services: Proteins, Expression, Isolation and Analysis

Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems

Authors: Lin Qi, Peter-James H Zushin, Ching-Fang Chang, Yue Tung Lee, Diana L Alba, Suneil K Koliwad, Andreas Stahl

Journal: Small

PubMed ID: 34761526

Doi: 10.1002/smll.202103157

Products & Services: Proteins, Expression, Isolation and Analysis

YAP Promotes Cell Proliferation and Stemness Maintenance of Porcine Muscle Stem Cells under High-Density Condition

Authors: Zheng Liu, Ling Lin, Haozhe Zhu, Zhongyuan Wu, Xi Ding, Rongrong Hu, Yichen Jiang, Changbo Tang, Shijie Ding, Renpeng Guo

Journal: Cells

PubMed ID: 34831292

Doi: 10.3390/cells10113069

Products & Services: Proteins, Expression, Isolation and Analysis

Chromium induced neurotoxicity by altering metabolism in zebrafish larvae

Authors: Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34781135

Doi: 10.1016/j.ecoenv.2021.112983

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A venom protein of ectoparasitoid Pachycrepoideus vindemiae, PvG6PDH, contributes to parasitism by inhibiting host glucose-6-phosphate metabolism

Authors: Lei Yang, Liming Qiu, Qi Fang, Shaoying Wu, Gongyin Ye

Journal: Insect Sci

PubMed ID: 34724344

Doi: 10.1111/1744-7917.12935

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Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vaccine for Shigellosis

Authors: Namrata Baruah, Nadim Ahamad, Suhrid Maiti, Debaki R Howlader, Ushasi Bhaumik, Vinod V Patil, Manoj K Chakrabarti, Hemanta Koley, Dhirendra S Katti

Journal: ACS Infect Dis

PubMed ID: 34734708

Doi: 10.1021/acsinfecdis.1c00345

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Improved production of the non-native cofactor F in Escherichia coli

Authors: Mihir V Shah, Hadi Nazem-Bokaee, James Antoney, Suk Woo Kang, Colin J Jackson, Colin Scott

Journal: Sci Rep

PubMed ID: 34741069

Doi: 10.1038/s41598-021-01224-3

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A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets

Authors: Daniel Zamith-Miranda, Heino M Heyman, Meagan C Burnet, Sneha P Couvillion, Xueyun Zheng, Nathalie Munoz, William C Nelson, Jennifer E Kyle, Erika M Zink, Karl K Weitz, Kent J Bloodsworth, Geremy Clair, Jeremy D Zucker, Jeremy R Teuton, Samuel H Payne, Young-Mo Kim, Morayma Reyes Gil, Erin S Baker, Erin L Bredeweg, Joshua D Nosanchuk, Ernesto S Nakayasu

Journal: MBio

PubMed ID: 34809453

Doi: 10.1128/mBio.02972-21

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Evaluation of recombinase-based isothermal amplification assays for point-of-need detection of SARS-CoV-2 in resource-limited settings

Authors: Prakash Ghosh, Rajashree Chowdhury, Mohammad Enayet Hossain, Faria Hossain, Mojnu Miah, Md Utba Rashid, James Baker, Mohammed Ziaur Rahman, Mustafizur Rahman, Xuejun Ma, Malcolm S Duthie, Ahmed Abd El Wahed, Dinesh Mondal

Journal: Int J Infect Dis

PubMed ID: 34758392

Doi: 10.1016/j.ijid.2021.11.007

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Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Authors: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong, Quanxin Long, Zihui Zhu, Yanying Yu, Jianping Wu, Jin Zhong, Rong Zhang, Shilong Fan, Guocai Zhong, Ailong Huang, Xinquan Wang, Qiang Ding

Journal: PLoS Pathog

PubMed ID: 34748603

Doi: 10.1371/journal.ppat.1010053

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ABAT targeted by miR-183-5p regulates cell functions in liver cancer

Authors: Hui Han, Shenkang Zhou, Gengzhen Chen, Yandi Lu, Hui Lin

Journal: Int J Biochem Cell Biol

PubMed ID: 34742920

Doi: 10.1016/j.biocel.2021.106116

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Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants

Authors: Qingbo Shu, Tara Kenny, Jia Fan, Christopher J Lyon, Lisa H Cazares, Tony Y Hu

Journal: PLoS Pathog

PubMed ID: 34748613

Doi: 10.1371/journal.ppat.1010039

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Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2

Authors: Junpei Ohtsuka, Masaki Imai, Masayuki Fukumura, Mitsuyo Maeda, Asami Eguchi, Ryoichi Ono, Tadashi Maemura, Mutsumi Ito, Seiya Yamayoshi, Yosky Kataoka, Yoshihiro Kawaoka, Tetsuya Nosaka

Journal: iScience

PubMed ID: 34805782

Doi: 10.1016/j.isci.2021.103379

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A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean

Authors: Weidong Wang, Liyang Chen, Kevin Fengler, Joy Bolar, Victor Llaca, Xutong Wang, Chancelor B Clark, Tomara J Fleury, Jon Myrvold, David Oneal, Maria Magdalena van Dyk, Ashley Hudson, Jesse Munkvold, Andy Baumgarten, Jeff Thompson, Guohong Cai, Oswald Crasta, Rajat Aggarwal, Jianxin Ma

Journal: Nat Commun

PubMed ID: 34741017

Doi: 10.1038/s41467-021-26554-8

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BAG3 induces α-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients

Authors: Margot De Marco, Nicoletta Del Papa, Francesca Reppucci, Vittoria Iorio, Anna Basile, Antonia Falco, Roberta Iaccarino, Sergio Brongo, Francesco De Caro, Mario Capunzo, Maria Caterina Turco, Alessandra Rosati, Liberato Marzullo

Journal: J Cell Biochem

PubMed ID: 34741483

Doi: 10.1002/jcb.30171

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An early wave of macrophage infiltration intertwined with antigen specific proinflammatory T-cells and browning of adipose tissue characterizes the onset of orbital inflammation in a mouse model of Graves' orbitopathy

Authors: Svenja Philipp, Mareike Horstmann, Matthias Hose, Anke Daser, Gina-Eva Görtz, Christoph Jesenek, Ulrich Flögel, Wiebke Hansen, Nikolaos Bechrakis, J Paul S Banga, Anja Eckstein, Utta Berchner-Pfannschmidt

Journal: Thyroid

PubMed ID: 34779257

Doi: 10.1089/thy.2021.0464

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Clinical Considerations During Breakthrough Coronavirus Disease 2019 Infections in Vaccinated Individuals With Autoimmunity

Authors: Joseph M Rocco, Luxin Pei, Frances Galindo, Elizabeth Laidlaw, Irini Sereti

Journal: Open Forum Infect Dis

PubMed ID: 34917696

Doi: 10.1093/ofid/ofab577

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Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Authors: Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol

Journal: Rev Soc Bras Med Trop

PubMed ID: 34787263

Doi: 10.1590/0037-8682-0385-2021

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High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation

Authors: Haide Chen, Yuan Liao, Guodong Zhang , Zhongyi Sun, Lei Yang, Xing Fang, Huiyu Sun, Lifeng Ma, Yuting Fu, Jingyu Li, Qile Guo, Xiaoping Han, Guoji Guo

Journal: Cell Discov

PubMed ID: 34750394

Doi: 10.1038/s41421-021-00333-7

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Secretion of Gluconic Acid From sp L1 Is Responsible for Solubilization of Aluminum Phosphate

Authors: Xiao Li Li, Xue Qiang Zhao, Xiao Ying Dong, Jian Feng Ma, Ren Fang Shen

Journal: Front Microbiol

PubMed ID: 34867925

Doi: 10.3389/fmicb.2021.784025

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Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases

Authors: Kaushik Sen, Sudeshna Datta, Arup Ghosh, Atimukta Jha, Abdul Ahad, Sanchari Chatterjee, Sandhya Suranjika, Soumya Sengupta, Gargee Bhattacharya, Omprakash Shriwas, Kiran Avula, Jayasingh Kshatri, Punit Prasad, Rajeeb Swain, Ajay K Parida, Sunil K Raghav

Journal: Front Immunol

PubMed ID: 34899693

Doi: 10.3389/fimmu.2021.733539

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A Novel ELISA-Based Peptide Biosensor Assay for Screening ABL1 Activity : A Challenge for Precision Therapy in BCR-ABL1 and BCR-ABL1 Like Leukemias

Authors: Oksana Montecchini, Stefania Braidotti, Raffaella Franca, Giulia Zudeh, Christian Boni, Claudio Sorio, Eleonora Toffoletti, Marco Rabusin, Alberto Tommasini, Giuliana Decorti, Gabriele Stocco

Journal: Front Pharmacol

PubMed ID: 34867354

Doi: 10.3389/fphar.2021.749361

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A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probe

Authors: Fan Hu, Lei Wang, Yishen Hu, Dongqi Wang, Weijie Wang, Jianbing Jiang, Nan Li, Peng Yin

Journal: Brief Bioinform

PubMed ID: 34368837

Doi: 10.1093/bib/bbab301

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Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair

Authors: M C Echave, I Erezuma, N Golafshan, M Castilho, F B Kadumudi, C Pimenta-Lopes, F Ventura, A Pujol, J J Jimenez, J A Camara, R Hernáez-Moya, L Iturriaga, L Sáenz Del Burgo, I Iloro, M Azkargorta, F Elortza, R Lakshminarayanan, T H Al-Tel, P García-García, R Reyes, A Delgado, C Évora, J L Pedraz, A Dolatshahi-Pirouz, G Orive

Journal: Biomater Adv

PubMed ID: 35513949

Doi: 10.1016/j.msec.2021.112539

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Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use

Authors: Chunyu Wang, Jiaxu Hong, Zhenlin Yang, Xujiao Zhou, Yuhan Yang, Yu Kong, Binfan Chen, Huifang Wu, Bin-Zhi Qian, Dimiter S Dimitrov, Xingtao Zhou, Yanling Wu, Tianlei Ying

Journal: Small Methods

PubMed ID: 35174992

Doi: 10.1002/smtd.202100966

Products & Services: Mammalian Expression

Robust Antibody Levels in Both Diabetic and Non-Diabetic Individuals After BNT162b2 mRNA COVID-19 Vaccination

Authors: Hamad Ali, Abdulmohsen Alterki, Sardar Sindhu, Barrak Alahmad, Maha Hammad, Salman Al-Sabah, Mohammad Alghounaim, Mohammad H Jamal, Ali Aldei, Mohammad J Mairza, Maitham Husain, Sriraman Deverajan, Rasheed Ahmad, Preethi Cherian, Irina Alkhairi, Abdullah Alkandari, Jehad Abubaker, Mohamed Abu-Farha, Fahd Al-Mulla

Journal: Front Immunol

PubMed ID: 34899701

Doi: 10.3389/fimmu.2021.752233

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Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia

Authors: Zhengli Bai, Menglong Xu, Ying Mei, Tuo Hu, Panpan Zhang, Manman Chen, Wenxiu Lv, Chenchen Lu, Shuhua Tan

Journal: Biomedicines

PubMed ID: 34944600

Doi: 10.3390/biomedicines9121783

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Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies

Authors: Jishnu Das, Jonathan K Fallon, Timothy C Yu, Ashlin Michell, Todd J Suscovich, Caitlyn Linde, Harini Natarajan, Joshua Weiner, Margherita Coccia, Scott Gregory, Margaret E Ackerman, Elke Bergmann-Leitner, Laura Fontana, Sheetij Dutta, Douglas A Lauffenburger, Erik Jongert, Ulrike Wille-Reece, Galit Alter

Journal: Med (N Y)

PubMed ID: 35590199

Doi: 10.1016/j.medj.2021.10.003

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Methodology to Quantify Collagen Subtypes and Crosslinks: Application in Minipig Cartilages

Authors: Benjamin J Bielajew, Jerry C Hu, Kyriacos A Athanasiou

Journal: Cartilage

PubMed ID: 34823380

Doi: 10.1177/19476035211060508

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Eurasian Avian-like M1 Plays More Important Role than M2 in Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice

Authors: Lixiang Xie, Guanlong Xu, Lingxiang Xin, Zhaofei Wang, Rujuan Wu, Mingqing Wu, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jingjiao Ma, Jianhe Sun

Journal: Viruses

PubMed ID: 34960604

Doi: 10.3390/v13122335

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Immuno-transcriptomic profiling of extracranial pediatric solid malignancies

Authors: Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia R C Toledo, Paul S Meltzer, Ching Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, Javed Khan

Journal: Cell Rep

PubMed ID: 34818552

Doi: 10.1016/j.celrep.2021.110047

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Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors

Authors: Kira Gysel, Mette Laursen, Mikkel B Thygesen, Damiano Lironi, Zoltán Bozsóki, Christian T Hjuler, Nicolai N Maolanon, Jeryl Cheng, Peter K Bjørk, Maria Vinther, Lene H Madsen, Henriette Rübsam, Artur Muszyński, Arshia Ghodrati, Parastoo Azadi, John T Sullivan, Clive W Ronson, Knud J Jensen, Mickaël Blaise, Simona Radutoiu, Jens Stougaard, Kasper R Andersen

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34716271

Doi: 10.1073/pnas.2111031118

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ACE Inhibitory Peptide from Skin Collagen Hydrolysate of as Potential for Protecting HUVECs Injury

Authors: Shuilin Cai, Nan Pan, Min Xu, Yongchang Su, Kun Qiao, Bei Chen, Bingde Zheng, Meitian Xiao, Zhiyu Liu

Journal: Mar Drugs

PubMed ID: 34940654

Doi: 10.3390/md19120655

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Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

Authors: Jorieke Weiden, Marjolein Schluck, Melina Ioannidis, Eric A W van Dinther, Mahboobeh Rezaeeyazdi, Fawad Omar, Juulke Steuten, Dion Voerman, Jurjen Tel, Mustafa Diken, Sidi A Bencherif, Carl G Figdor, Martijn Verdoes

Journal: ACS Biomater Sci Eng

PubMed ID: 34734689

Doi: 10.1021/acsbiomaterials.0c01648

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Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

Authors: Samuel Rivero-Hinojosa, Melanie Grant, Aswini Panigrahi, Huizhen Zhang, Veronika Caisova, Catherine M Bollard, Brian R Rood

Journal: Nat Commun

PubMed ID: 34795224

Doi: 10.1038/s41467-021-26936-y

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Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

Authors: Dennis J Doorduijn, Dani A C Heesterbeek, Maartje Ruyken, Carla J C de Haas, Daphne A C Stapels, Piet C Aerts, Suzan H M Rooijakkers, Bart W Bardoel

Journal: PLoS Pathog

PubMed ID: 34752492

Doi: 10.1371/journal.ppat.1010051

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Regulation of neuronal excitation-transcription coupling by Kv21-induced clustering of somatic L-type Ca channels at ER-PM junctions

Authors: Nicholas C Vierra, Samantha C O'Dwyer, Collin Matsumoto, L Fernando Santana, James S Trimmer

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34750263

Doi: 10.1073/pnas.2110094118

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Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Authors: Yaozong Chen, Lulu Sun, Irfan Ullah, Guillaume Beaudoin-Bussières, Sai Priya Anand, Andrew P Hederman, William D Tolbert, Rebekah Sherburn, Dung N Nguyen, Lorie Marchitto, Shilei Ding, Di Wu, Yuhong Luo, Suneetha Gottumukkala, Sean Moran, Priti Kumar, Grzegorz Piszczek, Walther Mothes, Margaret E Ackerman, Andrés Finzi, Pradeep D Uchil, Frank J Gonzalez, Marzena Pazgier

Journal: biorxiv

PubMed ID: 34845451

Doi: 10.1101/2021.11.24.469776

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AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

Authors: Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang

Journal: Nat Commun

PubMed ID: 34824276

Doi: 10.1038/s41467-021-27279-4

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Pharmacokinetics of Monoclonal Antibody and Antibody Fragments in the Mouse Eye Following Systemic Administration

Authors: David Bussing, Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo, Ashwni Verma, Dhaval K Shah

Journal: AAPS J

PubMed ID: 34750690

Doi: 10.1208/s12248-021-00647-0

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A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

Authors: Novalia Pishesha, Thibault J Harmand, Paul W Rothlauf, Patrique Praest, Ryan K Alexander, Renate van den Doel, Mariel J Liebeskind, Maria A Vakaki, Nicholas McCaul, Charlotte Wijne, Elisha Verhaar, William Pinney, Hailey Heston, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Ma Xenia G Ilagan, Robert Jan Lebbink, William J Buchser, Emmanuel J H J Wiertz, Sean P J Whelan, Hidde L Ploegh

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34654739

Doi: 10.1073/pnas.2116147118

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First cases of SARS-CoV-2 infection in dogs and cats in Thailand

Authors: Waleemas Jairak, Kamonpan Charoenkul, Ekkapat Chamsai, Kitikhun Udom, Supassama Chaiyawong, Napawan Bunpapong, Supanat Boonyapisitsopa, Rachod Tantilertcharoen, Navapon Techakriengkrai, Sirilak Surachetpong, Ratanaporn Tangwangvivat, Kamol Suwannakarn, Alongkorn Amonsin

Journal: Transbound Emerg Dis

PubMed ID: 34739748

Doi: 10.1111/tbed.14383

Immune signatures underlying post-acute COVID-19 lung sequelae

Authors: I S Cheon, C Li, Y M Son, N P Goplen, Y Wu, T Cassmann, Z Wang, X Wei, J Tang, Y Li, H Marlow, S Hughes, L Hammel, T M Cox, E Goddery, K Ayasoufi, D Weiskopf, J Boonyaratanakornkit, H Dong, H Li, R Chakraborty, A J Johnson, E Edell, J J Taylor, M H Kaplan, A Sette, B J Bartholmai, R Kern, R Vassallo, J Sun

Journal: Sci Immunol

PubMed ID: 34591653

Doi: 10.1126/sciimmunol.abk1741

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