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FRAGILE CULM 18 encodes a UDP-glucuronic acid decarboxylase required for xylan biosynthesis and plant growth in rice

Authors: Nan Ruan, Zhengjun Dang, Meihan Wang, Liyu Cao, Ye Wang, Sitong Liu, Yijun Tang, Yuwei Huang, Qun Zhang, Quan Xu, Wenfu Chen, Fengcheng Li

Journal: J Exp Bot

PubMed ID: 35104839

Doi: 10.1093/jxb/erac036

Products & Services: Protein Tools

Identification and Expression Analysis of WRKY Gene Family in Response to Abiotic Stress in

Authors: Tingting Zhang, Ying Xu, Yadan Ding, Wengang Yu, Jian Wang, Hanggui Lai, Yang Zhou

Journal: Front Genet

PubMed ID: 35186030

Doi: 10.3389/fgene.2022.800019

Products & Services: Protein Tools

Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses

Authors: Lin-Fa Wang, Chee Wah Tan, Wan Ni Chia, Feng Zhu, Barnaby Young, Napaporn Chantasrisawad, Shi-Hsia Hwa, Aileen Ying-Yan Yeoh, Beng Lee Lim, Wee Chee Yap, Surinder Kaur Pada, Seow Yen Tan, Watsamon Jantarabenjakul, Shiwei Chen, Jinyan Zhang, Yun Yan Mah, Vivian Chen, Mark Chen, Supaporn Wacharapluesadee, Commit-Kzn Team, Opass Putcharoen, David Lye

Journal: Res Sq

PubMed ID: 35233568

Doi: 10.21203/rs.3.rs-1362541/v1

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Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity

Authors: Sindhu Manivasagam, Jessica L Williams, Lauren L Vollmer, Bryan Bollman, Juliet M Bartleson, Shenjian Ai, Gregory F Wu, Robyn S Klein

Journal: J Immunol

PubMed ID: 35181638

Doi: 10.4049/jimmunol.2101041

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Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair

Authors: Robert J Lake, Rabeya Bilkis, Hua-Ying Fan

Journal: Biomedicines

PubMed ID: 35203571

Doi: 10.3390/biomedicines10020361

Products & Services: Protein Electrophoresis and Western

Construction and characterization of two SARS-CoV-2 minigenome replicon systems

Authors: Hu Zhang, Douglas K Fischer, Masahiro Shuda, Patrick S Moore, Shou-Jiang Gao, Zandrea Ambrose, Haitao Guo

Journal: J Med Virol

PubMed ID: 35137972

Doi: 10.1002/jmv.27650

Products & Services: ORF cDNA Clones/MolecularCloud

The function of glucose metabolism in embryonic diapause of annual killifish

Authors: Xiaowen Gao, Tianyi Cai, Yongtong Lin, Rui Zhu, Wenxin Hao, Shuming Guo, Guangfu Hu

Journal: Comp Biochem Physiol Part D Genomics Proteomics

PubMed ID: 35149343

Doi: 10.1016/j.cbd.2022.100965

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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Authors: Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen

Journal: Nucleic Acids Res

PubMed ID: 35212371

Doi: 10.1093/nar/gkac133

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Expression and characterization of a novel lytic polysaccharide monooxygenase, PdLPMO9A, from the edible fungus Pleurotus djamor and its synergistic interactions with cellulase in corn straw biomass saccharification

Authors: Yanli Li, Tongbing Li, Juntong Guo, Gang Wang, Guang Chen

Journal: Bioresour Technol

PubMed ID: 35121098

Doi: 10.1016/j.biortech.2022.126792

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Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1

Authors: Anastasia Zekeridou, Binxia Yang, Vanda A Lennon, Yong Guo, Liang Wu, Claudia F Lucchinetti, Andrew McKeon, Sean J Pittock, Eoin P Flanagan

Journal: Ann Neurol

PubMed ID: 35150165

Doi: 10.1002/ana.26320

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Dissecting Molecular Phenotypes Through FACS-Based Pooled CRISPR Screens

Authors: Oriana Genolet, Liat Ravid Lustig, Edda G Schulz

Journal: Methods Mol Biol

PubMed ID: 35218528

Doi: 10.1007/7651_2021_457

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Characterization, mRNA expression profile, subcellular distribution and association analysis with piglet diarrhea of porcine matrix metallopeptidase 7 (pMMP7)

Authors: Buyue Niu, Lu Liu, Zhihua Chen, Mingxing Kou, Xiuqin Yang, Yuan Sun, Shengwei Di, Xibiao Wang, Jiancheng Cai, Dongchun Guo

Journal: Gene

PubMed ID: 35182673

Doi: 10.1016/j.gene.2022.146319

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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability

Authors: Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian

Journal: Bioengineered

PubMed ID: 35081868

Doi: 10.1080/21655979.2021.2024962

Products & Services: ORF cDNA Clones/MolecularCloud

Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection

Authors: Yang Yang, Minghui Yang, Yun Peng, Yanhua Liang, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan, Yingxia Liu

Journal: Nat Microbiol

PubMed ID: 35132197

Doi: 10.1038/s41564-021-01051-2

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Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

Authors: Marta Ferraroni, Andrea Angeli, Simone Carradori, Claudiu T Supuran

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234146

Doi: 10.1107/S2059798322000079

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Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

Authors: Marta Ferraroni, Andrea Angeli, Simone Carradori, Claudiu T Supuran

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234146

Doi: 10.1107/S2059798322000079

Products & Services: Codon Optimization

FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

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PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

Authors: Ruhul H Choudhury, Peter Symonds, Samantha J Paston, Ian Daniels, Katherine W Cook, Mohamed Gijon, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 35140112

Doi: 10.1136/jitc-2021-003526

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CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

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Engineering laboratory/factory-specific phage-resistant strains of Escherichia coli by mutagenesis and screening

Authors: Qi Shen, Xiao-Ting Zhou, Qian Guo, Ya-Ping Xue, Yu-Guo Zheng

Journal: World J Microbiol Biotechnol

PubMed ID: 35128603

Doi: 10.1007/s11274-022-03239-y

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Engineering laboratory/factory-specific phage-resistant strains of Escherichia coli by mutagenesis and screening

Authors: Qi Shen, Xiao-Ting Zhou, Qian Guo, Ya-Ping Xue, Yu-Guo Zheng

Journal: World J Microbiol Biotechnol

PubMed ID: 35128603

Doi: 10.1007/s11274-022-03239-y

Products & Services: Protein Electrophoresis and Western

The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

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Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies

Authors: S Saellström, H Sharif, K K Jagarlamudi, H Rönnberg, L Wang, S Eriksson

Journal: Res Vet Sci

PubMed ID: 35245727

Doi: 10.1016/j.rvsc.2022.02.019

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Authors: Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan

Journal: Hum Vaccin Immunother

PubMed ID: 35209809

Doi: 10.1080/21645515.2022.2029111

Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro

Authors: Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35106909

Doi: 10.1111/jcmm.17212

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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

Authors: Lifeng Qin, Xin Liu, Li'na Lan, Xiaoping Lv

Journal: Int J Gen Med

PubMed ID: 35173468

Doi: 10.2147/IJGM.S343968

Products & Services: Gene Fragments

A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy

Authors: Yue Wang, Yaxian Mei, Zhenghong Ao, Yuanzhi Chen, Yichao Jiang, Xiaoqing Chen, Ruoyao Qi, Baorong Fu, Jixian Tang, Mujin Fang, Min You, Tianying Zhang, Quan Yuan, Wenxin Luo, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 35183645

Doi: 10.1016/j.antiviral.2022.105265

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Extended β-Strands Contribute to Reversible Amyloid Formation

Authors: Kevin A Murray, Declan Evans, Michael P Hughes, Michael R Sawaya, Carolyn J Hu, Kendall N Houk, David Eisenberg

Journal: ACS Nano

PubMed ID: 35132852

Doi: 10.1021/acsnano.1c08043

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Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

Authors: Nishanth Belugali Nataraj, Ashish Noronha, Joo Sang Lee, Soma Ghosh, Harsha Raj Mohan Raju, Arunachalam Sekar, Binyamin Zuckerman, Moshit Lindzen, Emilio Tarcitano, Swati Srivastava, Michael Selitrennik, Ido Livneh, Diana Drago-Garcia, Oscar Rueda, Carlos Caldas, Sima Lev, Tamar Geiger, Aaron Ciechanover, Igor Ulitsky, Rony Seger, Eytan Ruppin, Yosef Yarden

Journal: Cell Rep

PubMed ID: 35196484

Doi: 10.1016/j.celrep.2022.110418

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SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy

Authors: Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D Kwong, Walther Mothes, Maolin Lu

Journal: MBio

PubMed ID: 35164561

Doi: 10.1128/mbio.03227-21

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Germinal centre-driven maturation of B cell response to mRNA vaccination

Authors: Wooseob Kim, Julian Q Zhou, Stephen C Horvath, Aaron J Schmitz, Alexandria J Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, Sean P J Whelan, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: Nature

PubMed ID: 35168246

Doi: 10.1038/s41586-022-04527-1

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Disentangling the recognition complexity of a protein hub using a nanopore

Authors: Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S Cosgrove, Aaron James Wolfe, Liviu Movileanu

Journal: Nat Commun

PubMed ID: 35190547

Doi: 10.1038/s41467-022-28465-8

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A novel peptide-based electrochemical biosensor for breast cancer characterization over a poly 3-(3-aminophenyl) propionic acid matrix

Authors: Rafael da Fonseca Alves, Isabella Castro Martins, Diego Leoni Franco, Adriane das Graças Silva, Paula de Souza Santos, Luiz Ricardo Goulart, Yara Cristina de Paiva Maia, Alinne Tatiane Faria Silva, Thaise Gonçalves Araújo, Maria Del Pilar Taboada Sotomayor

Journal: Biosens Bioelectron

PubMed ID: 35217253

Doi: 10.1016/j.bios.2022.114081

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Performance evaluation of novel fluorescent-based lateral flow immunoassay (LFIA) for rapid detection and quantification of total anti-SARS-CoV-2 S-RBD binding antibodies in infected individuals

Authors: Farah M Shurrab, Nadin Younes, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Int J Infect Dis

PubMed ID: 35231609

Doi: 10.1016/j.ijid.2022.02.052

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Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants

Authors: Sing Mei Lim, Hoi Lok Cheng, Huan Jia, Patthara Kongsuphol, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Shuvan Prashant Turaga, Sascha P Heussler, Jyoti Somani, Sharmila Sengupta, Dousabel M Y Tay, Megan E McBee, Barnaby E Young, Paul A MacAry, Hadley D Sikes, Peter R Preiser

Journal: Bioeng Transl Med

PubMed ID: 35600666

Doi: 10.1002/btm2.10293

Elucidating the acid-base mechanisms underlying otolith overgrowth in fish exposed to ocean acidification

Authors: Garfield T Kwan, Martin Tresguerres

Journal: Sci Total Environ

PubMed ID: 35143791

Doi: 10.1016/j.scitotenv.2022.153690

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Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS

Authors: Jordan M Anderson, Jing Li, Timothy A Springer

Journal: Mol Biol Cell

PubMed ID: 35108026

Doi: 10.1091/mbc.E21-11-0536

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Functional antibody-dependent cell mediated cytotoxicity (ADCC) responses to vaccine and circulating influenza strains following vaccination

Authors: Xuemin Chen, He-Ying Sun, Chun Yi Lee, Christina A Rostad, Jessica Trost, Rodrigo B Abreu, Michael A Carlock, Jason R Wilson, Shane Gansebom, Ted M Ross, David A Steinhauer, Evan J Anderson, Larry J Anderson

Journal: Virology

PubMed ID: 35255298

Doi: 10.1016/j.virol.2022.02.004

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Design of Synthetic Mammalian Promoters Using Highly Palindromic Subsequences

Authors: Polina Govorkova, Chee Ka Candice Lam, Kevin Truong

Journal: ACS Synth Biol

PubMed ID: 35225601

Doi: 10.1021/acssynbio.1c00600

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A Necroptosis-Related Prognostic Model of Uveal Melanoma Was Constructed by Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases

Authors: Jiaheng Xie, Liang Chen, Qikai Tang, Wei Wei, Yuan Cao, Chuyan Wu, Jing Hang, Kai Zhang, Jingping Shi, Ming Wang

Journal: Front Immunol

PubMed ID: 35242144

Doi: 10.3389/fimmu.2022.847624

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Safety and immunogenicity of a live recombinant Newcastle disease virus-based COVID-19 vaccine (Patria) administered via the intramuscular or intranasal route: Interim results of a non-randomized open label phase I trial in Mexico

Authors: Samuel Ponce-de-León, Martha Torres, Luis Enrique Soto-Ramírez, Juan José Calva, Patricio Santillán-Doherty, Dora Eugenia Carranza-Salazar, Juan Manuel Carreño, Claudia Carranza, Esmeralda Juárez, Laura E Carreto-Binaghi, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Rosalía Vigueras-Moreno, Alejandro Ortiz-Stern, Yolanda López-Vidal, Alejandro E Macías, Jesús Torres-Flores, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Hisaaki Kawabata, Irene González-Domínguez, José Luis Martínez-Guevara, Weina Sun, David Sarfati-Mizrahi, Ernesto Soto-Priante, Héctor Elías Chagoya-Cortés, Constantino López-Macías, Felipa Castro-Peralta, Peter Palese, Adolfo García-Sastre, Florian Krammer, Bernardo Lozano-Dubernard

Journal: medrxiv

PubMed ID: 35169806

Doi: 10.1101/2022.02.08.22270676

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A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Authors: Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross A D Bathgate

Journal: Int J Mol Sci

PubMed ID: 35163827

Doi: 10.3390/ijms23031908

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Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

Authors: Bertrand Simon, Hua Jane Lou, Clotilde Huet-Calderwood, Guangda Shi, Titus J Boggon, Benjamin E Turk, David A Calderwood

Journal: Nat Commun

PubMed ID: 35136069

Doi: 10.1038/s41467-022-28427-0

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Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering

Authors: Andreas Santamaria, Krishna C Batchu, Olga Matsarskaia, Sylvain F Prévost, Daniela Russo, Francesca Natali, Tilo Seydel, Ingo Hoffmann, Valérie Laux, Michael Haertlein, Tamim A Darwish, Robert A Russell, Giacomo Corucci, Giovanna Fragneto, Armando Maestro, Nathan R Zaccai

Journal: J Am Chem Soc

PubMed ID: 35157798

Doi: 10.1021/jacs.1c09856

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Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus

Authors: Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Gülşen Sürmeli

Journal: Elife

PubMed ID: 35188100

Doi: 10.7554/eLife.73162

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Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase

Authors: Sabrina Patzelt, Manuela Pigors, Heiko Steenbock, Leonard Diel, Katharina Boch, Lenche Chakievska, Sven Künzel, Hauke Busch, Anke Fähnrich, Jürgen Brinckmann, Enno Schmidt

Journal: Front Immunol

PubMed ID: 35197965

Doi: 10.3389/fimmu.2021.812627

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An engineered bispecific human monoclonal antibody against SARS-CoV-2

Authors: Zhaohui Li, Shihua Li, Gen Zhang, Weiyu Peng, Zhen Chang, Xue Zhang, Zheng Fan, Yan Chai, Feiran Wang, Xin Zhao, Dedong Li, Rong Zhang, Zhanlong He, Weiwei Zou, Ke Xu, Wenwen Lei, Peipei Liu, Junfeng Hao, Jingjing Zhang, Litao Sun, Guizhen Wu, Shuguang Tan, George Fu Gao, Feng Gao, Yan Wu

Journal: Nat Immunol

PubMed ID: 35228696

Doi: 10.1038/s41590-022-01138-w

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Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Authors: Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman

Journal: Nat Commun

PubMed ID: 35136084

Doi: 10.1038/s41467-022-28424-3

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CRISPR-dCas9 based DNA detection scheme for diagnostics in resource-limited settings

Authors: Michel Bengtson, Mitasha Bharadwaj, Oskar Franch, Jaco van der Torre, Veronique Meerdink, Henk Schallig, Cees Dekker

Journal: Nanoscale

PubMed ID: 35044397

Doi: 10.1039/d1nr06557b

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Colicin E1 opens its hinge to plug TolC

Authors: S Jimmy Budiardjo, Jacqueline J Stevens, Anna L Calkins, Ayotunde P Ikujuni, Virangika K Wimalasena, Emre Firlar, David A Case, Julie S Biteen, Jason T Kaelber, Joanna S G Slusky

Journal: Elife

PubMed ID: 35199644

Doi: 10.7554/eLife.73297

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Jasmonic acid biosynthetic genes TgLOX4 and TgLOX5 are involved in daughter bulb development in tulip (Tulipa gesneriana)

Authors: Qi Sun, Bei Zhang, Chaolong Yang, Weiliang Wang, Lin Xiang, Yanping Wang, Zhulong Chan

Journal: Hortic Res

PubMed ID: 35147193

Doi: 10.1093/hr/uhac006

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Authors: Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B Hinkle, David Kan, Ehud Segal, Jason E Long, Tony Lima, Nicholas P D Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R Junttila, Andrey S Shaw, Mark Merchant, Matthew T Chang, Donald S Kirkpatrick, Shiva Malek

Journal: Cell Rep

PubMed ID: 35139374

Doi: 10.1016/j.celrep.2022.110351

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Role of IL-17 in Morphogenesis and Dissemination of during Murine Infection

Authors: Nuria Trevijano-Contador, Elena Roselletti, Rocío García-Rodas, Anna Vecchiarelli, Óscar Zaragoza

Journal: Microorganisms

PubMed ID: 35208830

Doi: 10.3390/microorganisms10020373

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Placental methylome reveals a 22q1333 brain regulatory gene locus associated with autism

Authors: Yihui Zhu, J Antonio Gomez, Benjamin I Laufer, Charles E Mordaunt, Julia S Mouat, Daniela C Soto, Megan Y Dennis, Kelly S Benke, Kelly M Bakulski, John Dou, Ria Marathe, Julia M Jianu, Logan A Williams, Orangel J Gutierrez Fugón, Cheryl K Walker, Sally Ozonoff, Jason Daniels, Luke P Grosvenor, Heather E Volk, Jason I Feinberg, M Daniele Fallin, Irva Hertz-Picciotto, Rebecca J Schmidt, Dag H Yasui, Janine M LaSalle

Journal: Genome Biol

PubMed ID: 35168652

Doi: 10.1186/s13059-022-02613-1

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Antibody responses to 2 doses of mRNA Covid vaccine in pediatric renal patients

Authors: Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu-Lung Lau

Journal: Kidney Int

PubMed ID: 35231464

Doi: 10.1016/j.kint.2022.01.035

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Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy

Authors: Hung X Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P Landstrom, Craig Henriquez, Nenad Bursac

Journal: Nat Commun

PubMed ID: 35110560

Doi: 10.1038/s41467-022-28251-6

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Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

Authors: Zhifeng Liu, Jianlin Xu, Haili Liu, Yong Wang

Journal: Microb Biotechnol

PubMed ID: 35174640

Doi: 10.1111/1751-7915.14000

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Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection

Authors: Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Viruses

PubMed ID: 35216022

Doi: 10.3390/v14020429

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Recombinant Mosquito Densovirus with Toxins Significantly Improves Pathogenicity against

Authors: Khadija Batool, Intikhab Alam, Peiwen Liu, Zeng Shu, Siyu Zhao, Wenqiang Yang, Xiao Jie, Jinbao Gu, Xiao-Guang Chen

Journal: Toxins (Basel)

PubMed ID: 35202174

Doi: 10.3390/toxins14020147

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Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis

Authors: Dogan Can Kirman, Bhuvanasundar Renganathan, Wai Kit Chui, Ming Wei Chen, Neslihan Arife Kaya, Ruowen Ge

Journal: Cell Death Dis

PubMed ID: 35197459

Doi: 10.1038/s41419-022-04618-x

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Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity

Authors: Monica Mesa-Perez, Phineas T Hamilton, Alex Miranda, Nicholas Brodie, Connor O'Sullivan, Jennifer Christie, Bridget C Ryan, Robert L Chow, David Goodlett, Christopher J Nelson, Perry L Howard

Journal: Nucleic Acids Res

PubMed ID: 35104878

Doi: 10.1093/nar/gkac033

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MPLA-Adjuvanted Liposomes Encapsulating S-Trimer or RBD or S1, but Not S-ECD, Elicit Robust Neutralization Against SARS-CoV-2 and Variants of Concern

Authors: Jian Wang, Xu-Guang Yin, Yu Wen, Jie Lu, Ru-Yan Zhang, Shi-Hao Zhou, Chun-Miao Liao, Hua-Wei Wei, Jun Guo

Journal: J Med Chem

PubMed ID: 35108485

Doi: 10.1021/acs.jmedchem.1c02025

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Heterologous Synthesis and Secretion of Ricinoleic Acid in Starmerella bombicola with Sophorolipid as an Intermediate

Authors: Mohor Chatterjee , Jay B Patel , Spencer T Stober, Xiaozhou Zhang

Journal: ACS Synth Biol

PubMed ID: 35157794

Doi: 10.1021/acssynbio.1c00457

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Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing

Authors: Guoxu Song , Fei Zhang , Chunhong Tian , Xing Gao, Xiaoxiao Zhu, Dongdong Fan, Yong Tian

Journal: Nucleic Acids Res

PubMed ID: 35188577

Doi: doi.org/10.1093/nar/gkac099

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African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-B Signaling Pathway

Authors: Qi Wang , Luyu Zhou , Jiang Wang , Dan Su , Dahua Li , Yongkun Du , Guoyu Yang , Gaiping Zhang , Beibei Chu

Journal: Viruses

PubMed ID: 35215987

Doi: 10.3390/v14020394

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Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

Authors: Cong Sun , Yin-Feng Kang , Yuan-Tao Liu , Xiang-Wei Kong , Hui-Qin Xu , Dan Xiong , Chu Xie , Yi-Hao Liu , Sui Peng , Guo-Kai Feng , Zheng Liu , Mu-Sheng Zeng

Journal: Signal Transduct Target Ther

PubMed ID: 35136040

Doi: 10.1038/s41392-022-00910-6

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Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3

Authors: Zhonggang Hou , Chunyi Hu , Ailong Ke , Yan Zhang

Journal: Curr Protoc

PubMed ID: 35129865

Doi: 10.1002/cpz1.361

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The receptor CgIL-17R1 expressed in granulocytes mediates the CgIL-17 induced haemocytes proliferation in Crassostrea gigas

Authors: Wanqing Cao, Weilin Wang, Siqi Fan, Jialuo Li, Qing Li, Shasha Wu, Lingling Wang, Linsheng Song

Journal: Dev Comp Immunol

PubMed ID: 35183562

Doi: 10.1016/j.dci.2022.104376

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High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors: Rosa Maria Chura-Chambi, Alvaro Rossan de Brandão Prieto-da-Silva, Matheus Martins Di Lela, João Ezequiel Oliveira, Patricia Estima Antonia Abreu, Luciana Regina Meireles, Heitor Franco de Andrade Junior, Ligia Morganti

Journal: PLoS ONE

PubMed ID: 35113919

Doi: 10.1371/journal.pone.0262591

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Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: Sci Transl Med

PubMed ID: 35166573

Doi: 10.1126/scitranslmed.abn8057

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Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine

Authors: Sayoni Ray, David M Wirth, Oscar A Ortega-Rivera, Nicole F Steinmetz, Jonathan K Pokorski

Journal: Biomacromolecules

PubMed ID: 35139303

Doi: 10.1021/acs.biomac.1c01345

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Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor

Authors: Hongmao Sun, Nathan P Coussens, Carina Danchik, Leah M Wachsmuth, Mark J Henderson, Samarjit Patnaik, Matthew D Hall, Ashley L Molinaro, Dayle A Daines, Min Shen

Journal: J Chem Inf Model

PubMed ID: 35103473

Doi: 10.1021/acs.jcim.1c01188

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Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics

Authors: Simon D Weaver, Naviya Schuster-Little, Rebecca J Whelan

Journal: Anal Methods

PubMed ID: 35175250

Doi: 10.1039/d1ay02145a

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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability

Authors: Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian

Journal: Bioengineered

PubMed ID: 35081868

Doi: 10.1080/21655979.2021.2024962

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Challenges of expressing recombinant human tissue factor as a secreted protein in

Authors: Mohammad Jalili-Nik, Mohammad Soukhtanloo, Majid Mojarrad, Mohammad Hadi Sadeghian, Baratali Mashkani

Journal: Prep Biochem Biotechnol

PubMed ID: 35133942

Doi: 10.1080/10826068.2021.2023823

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Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

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Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

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Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

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Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Authors: Gail Brenda Cross, Claire M Naftalin, Jinghao Nicholas Ngiam, Natasha Bagdasarian, Chek Meng Poh, Yun Shan Goh, Wan Ni Chia, Siti Naqiah Amrun, Sai Meng Tham, Hazel Teng, Rawan Alagha, Shoban Krishna Kumar, Shaun Shi Yan Tan, Lin Fa Wang, Paul Anantharajah Tambyah, Laurent Renia, Dale Fisher, Lisa F P Ng

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2

Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger

Journal: Vaccines (Basel)

PubMed ID: 35214780

Doi: 10.3390/vaccines10020322

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High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

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SARS-CoV-2 neutralizing capacity among blood donors without prior COVID-19 symptomatic history vs blood donors with prior COVID-19 symptomatic history: A comparative study

Authors: Ushasree Ravula, Srinivasa Rao Chunchu, Srujaleswari Mooli, Ravi Naik, Pandu Ranga Rao Sarangapati

Journal: Transfus Clin Biol

PubMed ID: 35167958

Doi: 10.1016/j.tracli.2022.02.004