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Ligand-directed bias of G protein signaling at the dopamine D2 receptor

Authors: Ee Von Moo , Kasper Harpsøe , Alexander S Hauser , Ikuo Masuho , Hans Bräuner-Osborne , David E Gloriam , Kirill A Martemyanov

Journal: Cell Chem Biol .

PubMed ID: 34302750

Doi: 10.1016/j.chembiol.2021.07.004

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and evaluation of imatinib as an inhibitor for SARS-CoV-2

Authors: Nirmitee Mulgaonkar, Haoqi Wang, Samavath Mallawarachchi, Daniel Růžek, Byron Martina, Sandun Fernando

Journal: J Biomol Struct Dyn

PubMed ID: 35220926

Doi: 10.1080/07391102.2022.2045221

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orter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Authors: Chan Zou, Jordan A Beard, Guoping Yang, William E Evans, Erik J Bonten

Journal: J Inflamm Res

PubMed ID: 35221708

Doi: 10.2147/JIR.S333725

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High density lipoprotein nanoparticle as delivery system for radio-sensitising miRNA: An investigation in 2D/3D head and neck cancer models

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Parisa Badiee, Benjamin Thierry

Journal: Int J Pharm

PubMed ID: 35176332

Doi: 10.1016/j.ijpharm.2022.121585

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A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds

Authors: Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu

Journal: Nanoscale

PubMed ID: 35167631

Doi: 10.1039/d1nr07452k

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Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation

Authors: Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Journal: J Leukoc Biol

PubMed ID: 35188700

Doi: 10.1002/JLB.1MA0122-513R

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Aqueous Extract of Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Authors: Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu, Xuemei Sun

Journal: J Inflamm Res

PubMed ID: 35210810

Doi: 10.2147/JIR.S345497

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Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects

Authors: Tzong-Shiann Ho, Pin-Xian Du, Wen-Yu Su, Harvey M Santos, Ya-Lan Lin, Yi-Yu Chou, Batuhan Birol Keskin, Chi Ho Pau, Guan-Da Syu

Journal: Biosens Bioelectron

PubMed ID: 35168024

Doi: 10.1016/j.bios.2022.114067

Vaccination Strategies at a COVID-19 Mass Vaccination Site

Authors: Sheng-Huang Hsiao, Sheng-Jean Huang, Chiao-Yu Huang

Journal: Int J Health Policy Manag

PubMed ID: 35247942

Doi: 10.34172/ijhpm.2022.6881

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Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Authors: Lingling Xu, Yinling Tan, Fengxia Xu, Yong Zhang

Journal: Bioengineered

PubMed ID: 35030964

Doi: 10.1080/21655979.2021.2019872

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membrane vesicles cause endothelial barrier failure and lung injury

Authors: Mark J McVey, Mazharul Maishan, Anna Foley, Razan Turki, Elyse J Roach, Rose Deschler, Sarah Weidenfeld, Neil M Goldenberg, Cezar M Khursigara, Wolfgang M Kuebler

Journal: Eur Respir J

PubMed ID: 35169027

Doi: 10.1183/13993003.01500-2021

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

Products & Services: ORF cDNA Clones/MolecularCloud

FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

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Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

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Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Sheng Luan, Dileep Vasudevan

Journal: Int J Biol Macromol

PubMed ID: 35218805

Doi: 10.1016/j.ijbiomac.2022.02.107

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OmpA may be used as a novel target to enrich and detect Escherichia coli in milk samples

Authors: Yichen Tian, Kaiqing Yang, Yaoqiang Shi, Jinyang Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song

Journal: J Dairy Sci

PubMed ID: 35151480

Doi: 10.3168/jds.2021-20974

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

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RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma

Authors: Mengshang Xiong, Ruoqi Liu, Xiaomin Lei, Dongmei Fan, Fangzhen Lin, Wei Hao, Xiangfei Yuan, Yuanyuan Yang, Xiaolong Zhang, Zhou Ye, Yang Lu, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

Journal: J Immunother

PubMed ID: 34711791

Doi: 10.1097/CJI.0000000000000401

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Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1

Authors: Yazhou Xiang, Yingjie Duan, Zhong Peng, Hong Huang, Wenjun Ding, En Chen, Zilong Liu, Chengyun Dou, Jianlong Li, Jihong Ou, Qingsong Wan, Bo Yang, Zhangxiu He

Journal: Calcif Tissue Int

PubMed ID: 35195734

Doi: 10.1007/s00223-022-00960-6

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Physiological ROS controls Upd3-dependent modeling of ECM to support cardiac function in

Authors: Jayati Gera, Prerna Budakoti, Meghna Suhag, Lolitika Mandal, Sudip Mandal

Journal: Sci Adv

PubMed ID: 35179958

Doi: 10.1126/sciadv.abj4991

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Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis

Authors: Ana Cristina Medeiros-Ribeiro, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Henrique Carriço da Silva, Carla G S Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Carlo Scognamiglio Renner Araujo, Tatiane Lie Nakai, Clóvis Artur Silva, Tatiana Pedrosa, Léonard de Vinci Kanda Kupa, Matheus Santos Rodrigues Silva, Guilherme Guimarães Moreira Balbi, Esper Georges Kallas, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35135832

Doi: 10.1136/annrheumdis-2021-221735

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miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level

Authors: Dapeng Wang, Jianbo Xiu, Jiangyue Zhao, Junli Luo

Journal: EMBO Rep

PubMed ID: 35201651

Doi: 10.15252/embr.202153691

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KIF18B promotes breast cancer cell proliferation, migration and invasion by targeting TRIP13 and activating the Wnt/β-catenin signaling pathway

Authors: Lan Liu, Zhaofeng Zhang, Xiulin Xia, Jing Lei

Journal: Oncol Lett

PubMed ID: 35251343

Doi: 10.3892/ol.2022.13232

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A CRISPR-based nucleic acid detection method for severe fever with thrombocytopenia syndrome virus

Authors: Yansong Zhang, Xuanyang Bai, Jinhui Li, Jing Xie, Huan Li, Lang Yang, Peihan Li, Peng Li, Hao Dong, Qichao Chen, Xinyan Hu, Yun Wang, Tingting Jiang, Hongbin Song, Leili Jia, Lizhong Li

Journal: Virus Res

PubMed ID: 35143909

Doi: 10.1016/j.virusres.2022.198691

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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Authors: Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard

Journal: Nat Commun

PubMed ID: 35110538

Doi: 10.1038/s41467-022-28113-1

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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Authors: Sheng-Han Kuo, Inmaculada Tasset, Melody M Cheng, Antonio Diaz, Ming-Kai Pan, Ori J Lieberman, Samantha J Hutten, Roy N Alcalay, Sangjun Kim, Pilar Ximénez-Embún, Li Fan, Donghoon Kim, Han Seok Ko, Talene Yacoubian, Ellen Kanter, Ling Liu, Guomei Tang, Javier Muñoz, Sergio Pablo Sardi, Aiqun Li, Li Gan, Ana Maria Cuervo, David Sulzer

Journal: Sci Adv

PubMed ID: 35138901

Doi: 10.1126/sciadv.abm6393

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CNOT6: A Novel Regulator of DNA Mismatch Repair

Authors: Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen

Journal: Cells

PubMed ID: 35159331

Doi: 10.3390/cells11030521

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mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

Authors: Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Journal: Life Sci Alliance

PubMed ID: 35169017

Doi: 10.26508/lsa.202201381

Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes

Authors: Jean-Pierre Bikorimana, Jamilah Abusarah, Natasha Salame, Nehme El-Hachem, Riam Shammaa, Moutih Rafei

Journal: Cells

PubMed ID: 35203247

Doi: 10.3390/cells11040596

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Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing

Authors: Xiaoxu Cui, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz

Journal: Virus Genes

PubMed ID: 35190939

Doi: 10.1007/s11262-022-01889-6

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Enzyme immunoassays (EIA) for serodiagnosis of human leptospirosis: specific IgG3/IgG1 isotyping may further inform diagnosis of acute disease

Authors: Elsa Fortes-Gabriel, Mariana Soares Guedes, Advait Shetty, Charles Klazer Gomes, Teresa Carreira, Maria Luísa Vieira, Lisa Esteves, Luísa Mota-Vieira, Maria Gomes-Solecki

Journal: PLoS Negl Trop Dis

PubMed ID: 35196321

Doi: 10.1371/journal.pntd.0010241

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Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins

Authors: Marina Pribanić Matešić, Paola Kučan Brlić, Tihana Lenac Roviš, Željka Mačak Šafranko, Abigael Eva Chaouat, Karmela Miklić, Suzana Malić, Nina Ivanković, Maren Schubert, Federico Bertoglio, Alemka Markotić, Ofer Mandelboim, Stipan Jonjić, Ilija Brizić

Journal: Viruses

PubMed ID: 35216036

Doi: 10.3390/v14020443

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Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

Authors: Onofrio Valente, Raffaella Messina, Giuseppe Ingravallo, Emilio Bellitti, Domenico Sergio Zimatore, Luigi de Gennaro, Pasqua Abbrescia, Roberta Pati, Claudia Palazzo, Grazia Paola Nicchia, Maria Trojano, Francesco Signorelli, Antonio Frigeri

Journal: Cell Mol Life Sci

PubMed ID: 35187599

Doi: 10.1007/s00018-021-04123-y

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ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Authors: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian

Journal: J Exp Clin Cancer Res

PubMed ID: 35227287

Doi: 10.1186/s13046-022-02288-3

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Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Authors: Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh-Ichi Nagata

Journal: Cells

PubMed ID: 35203342

Doi: 10.3390/cells11040696

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Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene

Authors: Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M Larabee, Cinthia B Drachenberg, Harris Yfantis, Jean-Pierre Raufman

Journal: JCI Insight

PubMed ID: 35015732

Doi: 10.1172/jci.insight.150894

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The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines

Authors: Izabela Figiel, Ewa Bączyńska, Tomasz Wójtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Włodarczyk

Journal: Sci Rep

PubMed ID: 35169214

Doi: 10.1038/s41598-022-06462-7

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Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Authors: Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su

Journal: Nat Commun

PubMed ID: 35228542

Doi: 10.1038/s41467-022-28721-x

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Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active

Authors: Kayla Glockzin, Thomas D Meek, Ardala Katzfuss

Journal: PLoS Negl Trop Dis

PubMed ID: 35104286

Doi: 10.1371/journal.pntd.0009926

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Immunogenicity and safety of an intradermal fractional third dose of ChAdOx1 nCoV-19/AZD1222 vaccine compared with those of a standard intramuscular third dose in volunteers who previously received two doses of CoronaVac: A randomized controlled trial

Authors: Kriangkrai Tawinprai, Taweegrit Siripongboonsitti, Thachanun Porntharukchareon, Kasiruck Wittayasak, Nawarat Thonwirak, Kamonwan Soonklang, Gaidganok Sornsamdang, Chirayu Auewarakul, Nithi Mahanonda

Journal: Vaccine

PubMed ID: 35210118

Doi: 10.1016/j.vaccine.2022.02.019

Reduced α-galactosidase A activity in zebrafish ( mirrors distinct features of Fabry nephropathy phenotype

Authors: Hassan O A Elsaid, Jessica Furriol, Maria Blomqvist, Mette Diswall, Sabine Leh, Naouel Gharbi, Jan Haug Anonsen, Janka Babickova, Camilla Tøndel, Einar Svarstad, Hans-Peter Marti, Maximilian Krause

Journal: Mol Genet Metab Rep

PubMed ID: 35242583

Doi: 10.1016/j.ymgmr.2022.100851

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Characterization of a Group of UDP-Glycosyltransferases Involved in the Biosynthesis of Triterpenoid Saponins of

Authors: Yanting Li, Jianxiu Li, Mengxue Diao, Longyun Peng, Shihai Huang, Nengzhong Xie

Journal: ACS Synth Biol

PubMed ID: 35107265

Doi: 10.1021/acssynbio.1c00469

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Poly(ADP-ribose) drives condensation of FUS via a transient interaction

Authors: Kevin Rhine, Morgan Dasovich, Joseph Yoniles, Mohsen Badiee, Sophie Skanchy, Laura R Ganser, Yingda Ge, Charlotte M Fare, James Shorter, Anthony K L Leung, Sua Myong

Journal: Mol Cell

PubMed ID: 35182479

Doi: 10.1016/j.molcel.2022.01.018

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Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease

Authors: Ádám Diós, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R Korponay-Szabó

Journal: Int J Mol Sci

PubMed ID: 35269639

Doi: 10.3390/ijms23052498

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Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer

Authors: Chao Zhang, Shuangqing Fu, Fanghua Zhang, Mengnan Han, Xuming Wang, Jie Du, Honglei Zhang, Wei Li

Journal: Nanomaterials (Basel)

PubMed ID: 35215023

Doi: 10.3390/nano12040696

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Blockage of NDUFB9‑SCD1 pathway inhibits adipogenesis

Authors: Shenglong Zhu, Jingwei Zhang, Wei Wang, Xuan Jiang, Yong Q Chen

Journal: J Physiol Biochem

PubMed ID: 35122619

Doi: 10.1007/s13105-022-00876-7

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Omicron adopts a different strategy from Delta and other variants to adapt to host

Authors: Xiaohong Du , Haijun Tang , Long Gao , Zhao Wu , Fang Meng , Ruhong Yan , Shigang Qiao, Jianzhong An , Chen Wang , F Xiao-Feng Qin

Journal: Signal Transduct Target Ther

PubMed ID: 35145066

Doi: 10.1038/s41392-022-00903-5

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Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Authors: Jung-Wan Mok , Kwang-Wook Choi

Journal: Cell Death Dis

PubMed ID: 35110540

Doi: 10.1038/s41419-022-04532-2

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Lack of Induction of RBD-Specific Neutralizing Antibodies despite Repeated Heterologous SARS-CoV-2 Vaccination Leading to Seroconversion and Establishment of T Cell-Specific Memory in a Patient in Remission of Multiple Myeloma

Authors: Bernhard Kratzer, Doris Trapin, Pia Gattinger, Teresa Oberhofer, Al Nasar Ahmed Sehgal, Petra Waidhofer-Söllner, Arno Rottal, Ulrike Körmöczi, Katharina Grabmeier-Pfistershammer, Gerhard H Kopetzky, Franz Tischer, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 35335006

Doi: 10.3390/vaccines10030374

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Myricetin reverses epithelial-endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Authors: Ming Wang, Shanfa Ren, Zhun Bi, Liang Zhang, Mengqi Cui, Ronghao Sun, Jiali Bao, Dandi Gao, Bo Yang, Xiaoping Li, Mingjiang Li, Ting Xiao, Hong-Gang Zhou, Cheng Yang

Journal: Phytother Res

PubMed ID: 35229382

Doi: 10.1002/ptr.7427

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Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment

Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng

Journal: Plant Cell Environ

PubMed ID: 35141923

Doi: 10.1111/pce.14286

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Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Authors: Mingxin Liu, Guizhou Tao, Yiming Cao, Yu Hu, Zhe Zhang

Journal: J Biochem Mol Toxicol

PubMed ID: 35179253

Doi: 10.1002/jbt.22994

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Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

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Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening

Authors: Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C E Tosatto

Journal: Cancers (Basel)

PubMed ID: 35205757

Doi: 10.3390/cancers14041009

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Melanocortin receptor agonists suppress experimental autoimmune uveitis

Authors: Tat Fong Ng, Kaleb Dawit, Andrew W Taylor

Journal: Exp Eye Res

PubMed ID: 35196505

Doi: 10.1016/j.exer.2022.108986

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Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking

Authors: Constancio Gonzalez-Obeso, Fredrik G Backlund, David L Kaplan

Journal: Biomacromolecules

PubMed ID: 35113522

Doi: 10.1021/acs.biomac.1c01192

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Photodynamic Activation of the Cholecystokinin 1 Receptor with Tagged Genetically Encoded Protein Photosensitizers: Optimizing the Tagging Patterns

Authors: Yuan Li, Zong Jie Cui

Journal: Photochem Photobiol

PubMed ID: 35211987

Doi: 10.1111/php.13611

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Photodynamic Activation of the Cholecystokinin 1 Receptor with Tagged Genetically Encoded Protein Photosensitizers: Optimizing the Tagging Patterns

Authors: Yuan Li, Zong Jie Cui

Journal: Photochem Photobiol

PubMed ID: 35211987

Doi: 10.1111/php.13611

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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Fitness benefits play a vital role in the retention of the Pi-ta susceptible alleles

Authors: Jia Liu, Suobing Zhang, Pengfei Xie, Long Wang, Jia-Yu Xue, Yanmei Zhang, Ruisen Lu, Yueyu Hang, Yue Wang, Xiaoqin Sun

Journal: Genetics

PubMed ID: 35143673

Doi: 10.1093/genetics/iyac019

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

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SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: Emerg Infect Dis

PubMed ID: 35076009

Doi: 10.3201/eid2802.211725

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Long noncoding RNASEH1-AS1 exacerbates the progression of non-small cell lung cancer by acting as a ceRNA to regulate microRNA-516a-5p/FOXK1 and thereby activating the Wnt/β-catenin signaling pathway

Authors: Chan Zhang, Jian Huang, Ke Lou, Hui Ouyang

Journal: Cancer Med

PubMed ID: 35166053

Doi: 10.1002/cam4.4509

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LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis

Authors: Yang Li, Yuanyuan Lv, Jiangya Wang, Xiuli Zhu, Jian Chen, Wenting Zhang, Chuan Wang, Lian Jiang

Journal: Arch Med Res

PubMed ID: 35164979

Doi: 10.1016/j.arcmed.2022.01.004

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Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins

Authors: Frederik G Tidemand, Sara Blemmer, Nicolai T Johansen, Lise Arleth, Martin Cramer Pedersen

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35182589

Doi: 10.1016/j.bbamem.2022.183884

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RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics

Authors: Thomas Biedenbänder, Vanessa de Jesus, Martina Schmidt-Dengler, Mark Helm, Björn Corzilius, Boris Fürtig

Journal: Nucleic Acids Res

PubMed ID: 35137185

Doi: 10.1093/nar/gkac040

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Authors: Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel M Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay

Journal: Nat Commun

PubMed ID: 35105861

Doi: 10.1038/s41467-022-28198-8

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E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2

Authors: Stephanie N Langel, Francine L Kelly, David M Brass, Andrew E Nagler, Dylan Carmack, Joshua J Tu, Tatianna Travieso, Ria Goswami, Sallie R Permar, Maria Blasi, Scott M Palmer

Journal: Cell Death Discov

PubMed ID: 35169120

Doi: 10.1038/s41420-022-00855-3

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Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana

Authors: Xiaodong Su, Duanfang Cao, Xiaowei Pan, Lifang Shi, Zhenfeng Liu, Luca Dall'Osto, Roberto Bassi, Xinzheng Zhang, Mei Li

Journal: Mol Plant

PubMed ID: 35123031

Doi: 10.1016/j.molp.2022.01.020

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Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

Authors: Xinxin Wang, Jie Luo, Zhiyuan Wen, Lei Shuai, Chong Wang, Gongxun Zhong, Xijun He, Huizhen Cao, Renqiang Liu, Jinying Ge, Ronghong Hua, Ziruo Sun, Xijun Wang, Jinliang Wang, Zhigao Bu

Journal: PLoS Pathog

PubMed ID: 35176124

Doi: 10.1371/journal.ppat.1010343

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Mesophyll conductance is unaffected by expression of Arabidopsis PIP1 aquaporins in the plasmalemma of Nicotiana

Authors: Victoria C Clarke, Baxter Massey, Aleu Mani George, John R Evans, Susanne von Caemmerer, Michael Groszmann

Journal: J Exp Bot

PubMed ID: 35184158

Doi: 10.1093/jxb/erac065

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Rapid, High Throughput, Automated Detection Of SARS-Cov-2 Neutralizing Antibodies Against Native-Like Vaccine And Delta Variant Spike Trimers

Authors: Narayanaiah Cheedarla, Hans Verkerke, Sindhu Potlapalli, Kaleb McLendon, Anamika Patel, Filipp Frank, Gregory Damhorst, Huixia Wu, William O'Sick, Daniel Graciaa, Fuad Hudaib, David Alter, Jeannette Bryksin, Eric Ortlund, Jeannette Guarner, Sara Auld, Sarita Shah, Wilbur Lam, Dawn Mattoon, Joseph Johnson, David Wilson, Madhav Dhodapkar, Sean Stowell, Andrew Neish, John Roback

Journal: Res Sq

PubMed ID: 35194599

Doi: 10.21203/rs.3.rs-1322411/v1

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Engineering of thick human functional myocardium via static stretching and electrical stimulation

Authors: Danielle Pretorius, Asher M Kahn-Krell, Wesley C LaBarge, Xi Lou, Jianyi Zhang

Journal: iScience

PubMed ID: 35243219

Doi: 10.1016/j.isci.2022.103824

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Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Authors: Christopher Chevillard, Axelle Amen, Solène Besson, Dalil Hannani, Isabelle Bally, Valentin Dettling, Evelyne Gout, Christophe J Moreau, Marlyse Buisson, Salomé Gallet, Daphna Fenel, Emilie Vassal-Stermann, Guy Schoehn, Pascal Poignard, Marie-Claire Dagher, Pascal Fender

Journal: Mol Ther

PubMed ID: 35151843

Doi: 10.1016/j.ymthe.2022.02.011

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Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1)

Authors: Lihua Liu, Aihua Liu, Jun Dong, Zhongfu Zuo, Xuezheng Liu

Journal: Exp Cell Res

PubMed ID: 35192838

Doi: 10.1016/j.yexcr.2022.113075

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