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CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma

Authors: Wen Lei, Qian Ye, Yuanyuan Hao, Jie Chen, Yu Huang, Liu Yang, Shibing Wang, Wenbin Qian

Journal: Blood Cancer J

PubMed ID: 35228544

Doi: 10.1038/s41408-022-00634-4

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A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Authors: Mingzhe Sun, Shihao Li, Songjun Jin, Xuechun Li, Jianhai Xiang, Fuhua Li

Journal: Front Immunol

PubMed ID: 35281067

Doi: 10.3389/fimmu.2022.819881

Products & Services: Protein and Antibody Isolation

Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management

Authors: Marlène Damin-Pernik, Abdessalem Hammed, Ludivine Giraud, Joffrey Goulois, Etienne Benoît, Virginie Lattard

Journal: Pestic Biochem Physiol

PubMed ID: 35430058

Doi: 10.1016/j.pestbp.2022.105052

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Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors

Authors: Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton

Journal: Biosensors (Basel)

PubMed ID: 35323413

Doi: 10.3390/bios12030143

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Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing

Authors: Bo Zhao, Weiding Wang, Yu Liu, Siyu Guan, Manman Wang, Fang Song, Wenfeng Shangguan, Shuai Miao, Xiaowei Zhang, Huijia Liu, Enzhao Liu, Xue Liang

Journal: J Interv Card Electrophysiol

PubMed ID: 35124782

Doi: 10.1007/s10840-022-01120-4

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Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2

Authors: Stéphane Hazebrouck, Sarita U Patil, Blanche Guillon, Nicole Lahood, Stephen C Dreskin, Karine Adel-Patient, Hervé Bernard

Journal: J Allergy Clin Immunol

PubMed ID: 35150723

Doi: 10.1016/j.jaci.2021.12.796

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

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Genome-wide association study and functional follow-up identifies 14q12 as a candidate risk locus for cervical cancer

Authors: Dhanya Ramachandran, Joe Dennis, Laura Fachal, Peter Schürmann, Kristine Bousset, Fabienne Hülse, Qianqian Mao, Yingying Wang, Matthias Jentschke, Gerd Böhmer, Hans-Georg Strauß, Christine Hirchenhain, Monika Schmidmayr, Florian Müller, Ingo Runnebaum, Alexander Hein, Frederik Stübs, Martin Koch, Matthias Ruebner, Matthias W Beckmann, Peter A Fasching, Alexander Luyten, Matthias Dürst, Peter Hillemanns, Douglas F Easton, Thilo Dörk

Journal: Hum Mol Genet

PubMed ID: 35157032

Doi: 10.1093/hmg/ddac031

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

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Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Authors: Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan

Journal: Hum Vaccin Immunother

PubMed ID: 35209809

Doi: 10.1080/21645515.2022.2029111

Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro

Authors: Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35106909

Doi: 10.1111/jcmm.17212

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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

Authors: Lifeng Qin, Xin Liu, Li'na Lan, Xiaoping Lv

Journal: Int J Gen Med

PubMed ID: 35173468

Doi: 10.2147/IJGM.S343968

Products & Services: Gene Fragments

Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

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A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy

Authors: Yue Wang, Yaxian Mei, Zhenghong Ao, Yuanzhi Chen, Yichao Jiang, Xiaoqing Chen, Ruoyao Qi, Baorong Fu, Jixian Tang, Mujin Fang, Min You, Tianying Zhang, Quan Yuan, Wenxin Luo, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 35183645

Doi: 10.1016/j.antiviral.2022.105265

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Metal Dependence and Functional Diversity of Type I Cas3 Nucleases

Authors: Sining Sun, Zunyu He, Paul Jiang, Rishika Baral, Maria-Eirini Pandelia

Journal: Biochemistry

PubMed ID: 35184547

Doi: 10.1021/acs.biochem.1c00779

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Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2

Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger

Journal: Vaccines (Basel)

PubMed ID: 35214780

Doi: 10.3390/vaccines10020322

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Development of a Test Card Based on Colloidal Gold Immunochromatographic Strips for Rapid Detection of Antibodies against Theileria equi and Babesia caballi

Authors: Guangpu Yang, Kewei Chen, Wei Guo, Zhe Hu, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du, Xiaojun Wang

Journal: Microbiol Spectr

PubMed ID: 35196786

Doi: 10.1128/spectrum.02411-21

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Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment

Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng

Journal: Plant Cell Environ

PubMed ID: 35141923

Doi: 10.1111/pce.14286

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Cytolysin A-mediated protein exportation efficiency and its role in enhancing the fitness of live recombinant Salmonella Typhi vaccine strain

Authors: F-K Loh, S Nathan, S-C Chow, C-M Fang

Journal: Lett Appl Microbiol

PubMed ID: 35138654

Doi: 10.1111/lam.13669

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Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Authors: Mingxin Liu, Guizhou Tao, Yiming Cao, Yu Hu, Zhe Zhang

Journal: J Biochem Mol Toxicol

PubMed ID: 35179253

Doi: 10.1002/jbt.22994

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High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

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Inhibition of the Interaction of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival in Hepatic Ischemia/Reperfusion

Authors: Timothy Borjas, Asha Jacob, HaoTing Yen, Vihas Patel, Gene F Coppa, Monowar Aziz, Ping Wang

Journal: Shock

PubMed ID: 34864782

Doi: 10.1097/SHK.0000000000001894

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

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IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine

Authors: Lina G Mettler, Karin Brecht, Veronika Butterweck, Henriette E Meyer Zu Schwabedissen

Journal: Biomed Pharmacother

PubMed ID: 35149385

Doi: 10.1016/j.biopha.2022.112698

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Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol

PubMed ID: 35231466

Doi: 10.1016/j.dci.2022.104379

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Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S Manola, Panagiotis Malandrakis, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Biomedicines

PubMed ID: 35203547

Doi: 10.3390/biomedicines10020338

Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

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Distinct Homologous and Variant-Specific Memory B-Cell and Antibody Response Over Time after SARS-CoV-2 mRNA Vaccination

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: J Infect Dis

PubMed ID: 35137144

Doi: 10.1093/infdis/jiac042

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Biochemical Screening of Potent Zika Virus Protease Inhibitors

Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele

Journal: ChemMedChem

PubMed ID: 35104396

Doi: 10.1002/cmdc.202100695

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A genome-wide CRISPR screen identifies HuR as a regulator of apoptosis induced by dsRNA and virus

Authors: Huixin Gao, Yuxia Lin, Changbai Huang, Xiaobo Li, Michael S Diamond, Chao Liu, Rong Zhang, Ping Zhang

Journal: J Cell Sci

PubMed ID: 35112703

Doi: 10.1242/jcs.258855

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SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: Emerg Infect Dis

PubMed ID: 35076009

Doi: 10.3201/eid2802.211725

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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Authors: Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries

Journal: Front Mol Biosci

PubMed ID: 35211509

Doi: 10.3389/fmolb.2022.811116

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A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma

Authors: Mengshang Xiong, Ruoqi Liu, Xiaomin Lei, Dongmei Fan, Fangzhen Lin, Wei Hao, Xiangfei Yuan, Yuanyuan Yang, Xiaolong Zhang, Zhou Ye, Yang Lu, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

Journal: J Immunother

PubMed ID: 34711791

Doi: 10.1097/CJI.0000000000000401

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LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis

Authors: Yang Li, Yuanyuan Lv, Jiangya Wang, Xiuli Zhu, Jian Chen, Wenting Zhang, Chuan Wang, Lian Jiang

Journal: Arch Med Res

PubMed ID: 35164979

Doi: 10.1016/j.arcmed.2022.01.004

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Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins

Authors: Frederik G Tidemand, Sara Blemmer, Nicolai T Johansen, Lise Arleth, Martin Cramer Pedersen

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35182589

Doi: 10.1016/j.bbamem.2022.183884

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RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics

Authors: Thomas Biedenbänder, Vanessa de Jesus, Martina Schmidt-Dengler, Mark Helm, Björn Corzilius, Boris Fürtig

Journal: Nucleic Acids Res

PubMed ID: 35137185

Doi: 10.1093/nar/gkac040

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Authors: Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel M Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay

Journal: Nat Commun

PubMed ID: 35105861

Doi: 10.1038/s41467-022-28198-8

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TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer

Authors: Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae

Journal: Int J Mol Sci

PubMed ID: 35216272

Doi: 10.3390/ijms23042157

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From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion

Authors: Ana Catarina Lopes, Julien Brechbühl, Flavio Ferreira, Marjorie Amez-Droz, Marie-Christine Broillet

Journal: Animals (Basel)

PubMed ID: 35158677

Doi: 10.3390/ani12030356

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Far-Red Light Triggered Production of Bispecific T Cell Engagers (BiTEs) from Engineered Cells for Antitumor Application

Authors: Cuilin Zhang, Yingjun Shi, Lingjie Wu, Chenyi Wang, Naishun Liao, Fei Wang, Bixing Zhao, Yingchao Wang, Xiaolong Liu

Journal: ACS Synth Biol

PubMed ID: 35113526

Doi: 10.1021/acssynbio.1c00523

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The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice

Authors: Spencer Iner Thomas Berg, Justin Knapp, Marsela Braunstein, Cody Shirriff

Journal: Autoimmunity

PubMed ID: 35137667

Doi: 10.1080/08916934.2022.2027921

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SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

Authors: David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse Erasmus

Journal: Elife

PubMed ID: 35191378

Doi: 10.7554/eLife.75537

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Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease

Authors: Richard G Lee, Shanti Balasubramaniam, Maike Stentenbach, Tom Kralj, Timothy McCubbin, Benjamin Padman, Janine Smith, Lisa G Riley, Archana Priyadarshi, Liuyu Peng, Madison R Nuske, Richard Webster, Ken Peacock, Philip Roberts, Zornitza Stark, Gabrielle Lemire, Yoko A Ito, Kym M Boycott, Michael T Geraghty, Jan Bert Klinken, Sacha Ferdinandusse, Ying Zhou, Rebecca Walsh, Esteban Marcellin, David R Thorburn, Tony Rosciolli, Janice Fletcher, Oliver Rackham, Frédéric M Vaz, Gavin E Reid, Aleksandra Filipovska

Journal: Hum Mol Genet

PubMed ID: 35147173

Doi: 10.1093/hmg/ddac040

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Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa

Authors: Yan Hui Yang, Mu Rong Yang, Jian Yu Zhu, Ke Wei Dong, Yan Jie Yi, Rui Fang Li, Lei Zeng, Chang Fu Zhang

Journal: Planta

PubMed ID: 35147783

Doi: 10.1007/s00425-022-03849-8

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Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque

Authors: Xuedong Dai, Weijun Zhao, Xin Tong, Wei Liu, Xianhuan Zeng, Xiaohui Duan, Hua Wu, Lili Wang, Zhen Huang, Xinying Tang, Yong Yang

Journal: Arch Toxicol

PubMed ID: 35226134

Doi: 10.1007/s00204-021-03221-x

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Ca Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells

Authors: Beibei Wu, Jin Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack

Journal: J Immunol

PubMed ID: 35217583

Doi: 10.4049/jimmunol.2100871

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Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB

Authors: Maira Rivera, Pablo Galaz-Davison, Ignacio Retamal-Farfán, Elizabeth A Komives, César A Ramírez-Sarmiento

Journal: Biophys J

PubMed ID: 35151633

Doi: 10.1016/j.bpj.2022.02.012

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Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines

Authors: XiaoJing Chen, Yite Xue, Lingfang Wang, Yang Weng, Sen Li, Weiguo Lü, Xing Xie, Xiaodong Cheng

Journal: Bioengineered

PubMed ID: 35038949

Doi: 10.1080/21655979.2021.2022844

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Rapid, Visual, and Sequence-Specific Detection of in Egg Liquid with vis-NEAA, a CRISPR/Cas12 Empowered New Strategy

Authors: Linlin Bai, Liu Wang, Shuqin Huang, Rong Bai, Xucong Lv, Liping Sun, Fang Zhang, Xiahong Xu

Journal: J Agric Food Chem

PubMed ID: 35138842

Doi: 10.1021/acs.jafc.1c06715

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encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in

Authors: Yan-Hua Liu, Hao Wang, Jie-Xia Liu, Sheng Shu, Guo-Fei Tan, Meng-Yao Li, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: PeerJ

PubMed ID: 35233296

Doi: 10.7717/peerj.12976

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encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in

Authors: Yan-Hua Liu, Hao Wang, Jie-Xia Liu, Sheng Shu, Guo-Fei Tan, Meng-Yao Li, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: PeerJ

PubMed ID: 35233296

Doi: 10.7717/peerj.12976

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Challenges of expressing recombinant human tissue factor as a secreted protein in

Authors: Mohammad Jalili-Nik, Mohammad Soukhtanloo, Majid Mojarrad, Mohammad Hadi Sadeghian, Baratali Mashkani

Journal: Prep Biochem Biotechnol

PubMed ID: 35133942

Doi: 10.1080/10826068.2021.2023823

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Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection

Authors: Yang Yang, Minghui Yang, Yun Peng, Yanhua Liang, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan, Yingxia Liu

Journal: Nat Microbiol

PubMed ID: 35132197

Doi: 10.1038/s41564-021-01051-2

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Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

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A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

Authors: M Gordon Joyce, Hannah A D King, Ines Elakhal-Naouar, Aslaa Ahmed, Kristina K Peachman, Camila Macedo Cincotta, Caroline Subra, Rita E Chen, Paul V Thomas, Wei-Hung Chen, Rajeshwer S Sankhala, Agnes Hajduczki, Elizabeth J Martinez, Caroline E Peterson, William C Chang, Misook Choe, Clayton Smith, Parker J Lee, Jarrett A Headley, Mekdi G Taddese, Hanne A Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James Brett Case, Jeffrey R Currier, Kerri G Lal, Sebastian Molnar, Manoj S Nair, Vincent Dussupt, Sharon P Daye, Xiankun Zeng, Erica K Barkei, Hilary M Staples, Kendra Alfson, Ricardo Carrion, Shelly J Krebs, Dominic Paquin-Proulx, Nicos Karasavva, Victoria R Polonis, Linda L Jagodzinski, Mihret F Amare, Sandhya Vasan, Paul T Scott, Yaoxing Huang, David D Ho, Natalia de Val, Michael S Diamond, Mark G Lewis, Mangala Rao, Gary R Matyas, Gregory D Gromowski, Sheila A Peel, Nelson L Michael, Diane L Bolton, Kayvon Modjarrad

Journal: Sci Transl Med

PubMed ID: 34914540

Doi: 10.1126/scitranslmed.abi5735

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Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

Authors: Yingying Wang, Xi Chen, Katharina Spengler, Karoline Terberger, Marko Boehm, Jens Appel, Thomas Barske, Stefan Timm, Natalia Battchikova, Martin Hagemann, Kirstin Gutekunst

Journal: Elife

PubMed ID: 35138247

Doi: 10.7554/eLife.71339

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The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory human intestinal model

Authors: Benthe van der Lugt, Maartje C P Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink, Wilma T Steegenga

Journal: Heliyon

PubMed ID: 35169646

Doi: 10.1016/j.heliyon.2022.e08883

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Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus

Authors: Shikun Ge, Rao Wu, Tingting Zhou, Xiang Liu, Jin Zhu, Xiaoying Zhang

Journal: AMB Express

PubMed ID: 35150368

Doi: 10.1186/s13568-022-01355-4

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Characterization of gluten-degrading prolyl endoprotease from Thermococcus kodakarensis

Authors: Radhakrishna Shetty, Claus Heiner Bang-Berthelsen, Klaudia Weronika Ciurkot, Mike Vestergaard, Per Mårten Hägglund, Harishchandra S Prakash, Timothy John Hobley

Journal: FEMS Microbiol Lett

PubMed ID: 35038331

Doi: 10.1093/femsle/fnac006

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Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

Authors: Jingwei Xu, Charles F Ericson, Yun-Wei Lien, Florentine U N Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165385

Doi: 10.1038/s41564-022-01059-2

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A truncated CC-NB-ARC gene TaRPP13L1-3D positively regulates powdery mildew resistance in wheat via the RanGAP-WPP complex-mediated nucleocytoplasmic shuttle

Authors: Xiangyu Zhang, Guanghao Wang, Xiaojian Qu, Mengmeng Wang, Huan Guo, Lu Zhang, Tingdong Li, Yajuan Wang, Hong Zhang, Wanquan Ji

Journal: Planta

PubMed ID: 35133503

Doi: 10.1007/s00425-022-03843-0

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Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis

Authors: Ya Yang, Yanfei Chen, Yalei Zhao, Feiyang Ji, Lingjian Zhang, Shima Tang, Sainan Zhang, Qingqing Hu, Zuhong Li, Fen Zhang, Qian Li, Lanjuan Li

Journal: Stem Cell Res Ther

PubMed ID: 35123555

Doi: 10.1186/s13287-022-02734-1

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Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice

Authors: Lucía Pérez, Rui Alves, Laura Perez-Fons, Alfonso Albacete, Gemma Farré, Erika Soto, Ester Vilaprinyó, Cristina Martínez-Andújar, Oriol Basallo, Paul D Fraser, Vicente Medina, Changfu Zhu, Teresa Capell, Paul Christou

Journal: Transgenic Res

PubMed ID: 35201538

Doi: 10.1007/s11248-022-00299-6

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The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging

Authors: Yilin Ying, Xuefei Hu, Peng Han, Aaron Mendez-Bermudez, Serge Bauwens, Rita Eid, Li Tan, Mélanie Pousse, Marie-Joseph Giraud-Panis, Yiming Lu, Eric Gilson, Jing Ye

Journal: Nucleic Acids Res

PubMed ID: 35150283

Doi: 10.1093/nar/gkac065

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Immune Response of Adult Sickle Cell Disease Patients after COVID-19 Vaccination: The Experience of a Greek Center

Authors: Christos Varelas, Eleni Gavriilaki, Ioanna Sakellari, Philippos Klonizakis, Evaggelia-Evdoxia Koravou, Ioanna Christodoulou, Ioulia Mavrikou, Andreas Kourelis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Tasoula Touloumenidou, Apostolia Papalexandri, Achilles Anagnostopoulos, Efthimia Vlachaki

Journal: J Clin Med

PubMed ID: 35207208

Doi: 10.3390/jcm11040937

Expressing 2-keto acid pathway enzymes significantly increases photosynthetic isobutanol production

Authors: Hao Xie, Peter Lindblad

Journal: Microb Cell Fact

PubMed ID: 35105340

Doi: 10.1186/s12934-022-01738-z

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

Authors: Mingzhu Yang, Hanwen Yu, Xiu Yu, Shiqi Liang, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvák, Chuanbo Sun, Jichang Wang

Journal: Cell Stem Cell

PubMed ID: 35143761

Doi: 10.1016/j.stem.2022.01.010

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Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA

Authors: Fernando Rodriguez, Irina A Yushenova, Daniel DiCorpo, Irina R Arkhipova

Journal: Nat Commun

PubMed ID: 35228526

Doi: 10.1038/s41467-022-28471-w

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Metabolic Division in an Coculture System for Efficient Production of Kaempferide

Authors: Zetian Qiu, Xue Liu, Jia Li, Bin Qiao, Guang-Rong Zhao

Journal: ACS Synth Biol

PubMed ID: 35167258

Doi: 10.1021/acssynbio.1c00510

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Grafting Watermelon Onto Pumpkin Increases Chilling Tolerance by Up Regulating to Increase Putrescine Biosynthesis

Authors: Junyang Lu, Fei Cheng, Yuan Huang, Zhilong Bie

Journal: Front Plant Sci

PubMed ID: 35242149

Doi: 10.3389/fpls.2021.812396

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ATPase subunits of the 26S proteasome are important for oocyte maturation in the brown planthopper

Authors: Xu Cheng, Wei Wang, Lu Zhang, Rui-Rui Yang, Ya Ma, Yan-Yuan Bao

Journal: Insect Mol Biol

PubMed ID: 35084067

Doi: 10.1111/imb.12761

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The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

Authors: Galen J Correy, Daniel W Kneller, Gwyndalyn Phillips, Swati Pant, Silvia Russi, Aina E Cohen, George Meigs, James M Holton, Stefan Gahbauer, Michael C Thompson, Alan Ashworth, Leighton Coates, Andrey Kovalevsky, Flora Meilleur, James S Fraser

Journal: biorxiv

PubMed ID: 35169801

Doi: 10.1101/2022.02.07.479477

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Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer

Authors: Kwang-Hyeok Kim, Jin-Ock Kim, Jeong-Yang Park, Min-Duk Seo, Sang Gyu Park

Journal: Int J Mol Sci

PubMed ID: 35216379

Doi: 10.3390/ijms23042264

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

Authors: Chi-Chuan Lin, Kin Man Suen, Polly-Anne Jeffrey, Lukasz Wieteska, Jessica A Lidster, Peng Bao, Alistair P Curd, Amy Stainthorp, Caroline Seiler, Hans Koss, Eric Miska, Zamal Ahmed, Stephen D Evans, Carmen Molina-París, John E Ladbury

Journal: Mol Cell

PubMed ID: 35231400

Doi: 10.1016/j.molcel.2022.02.005

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Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis

Authors: Albert Tsai, Justin Crocker

Journal: Development

PubMed ID: 35142344

Doi: 10.1242/dev.200266

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Strategy for Conjugating Oligopeptides to Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers

Authors: Md Arif Khan, Ramy W Ghanim, Maelyn R Kiser, Mahsa Moradipour, Dennis T Rogers, John M Littleton, Luke H Bradley, Bert C Lynn, Stephen E Rankin, Barbara L Knutson

Journal: Nanomaterials (Basel)

PubMed ID: 35214937

Doi: 10.3390/nano12040608

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Phosphorylation of MdERF17 by MdMPK4 Promotes Apple Fruit Peel Degreening during Light/Dark Transitions

Authors: Shuai Wang, Ting Wang, Qiqi Li, Chen Xu, Ji Tian, Yi Wang, Xinzhong Zhang, Xuefeng Xu, Zhenhai Han, Ting Wu

Journal: Plant Cell

PubMed ID: 35166845

Doi: 10.1093/plcell/koac049

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Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients

Authors: Jessica Bassi, Olivier Giannini, Chiara Silacci-Fregni, Laura Pertusini, Paolo Hitz, Tatiana Terrot, Yves Franzosi, Francesco Muoio, Christian Saliba, Marcel Meury, Exequiel A Dellota, Josh R Dillen, Patrick Hernandez, Nadine Czudnochowski, Elisabetta Cameroni, Nicola Beria, Mariangela Ventresca, Alberto Badellino, Soraya Lavorato-Hadjeres, Elisabetta Lecchi, Tecla Bonora, Matteo Mattiolo, Guido Trinci, Daniela Garzoni, Giuseppe Bonforte, Valentina Forni-Ogna, Davide Giunzioni, Lorenzo Berwert, Ravindra K Gupta, Paolo Ferrari, Alessandro Ceschi, Pietro Cippà, Davide Corti, Antonio Lanzavecchia, Luca Piccoli

Journal: PLoS ONE

PubMed ID: 35143540

Doi: 10.1371/journal.pone.0263328

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Microsphere Peptide-Based Immunoassay for the Detection of Recombinant Bovine Somatotropin in Injection Preparations

Authors: Nathalie G E Smits, Toine F H Bovee, Sidharam P Pujari, Leendert A van Ginkel, Michel W F Nielen, Bauke Albada

Journal: Biosensors (Basel)

PubMed ID: 35323408

Doi: 10.3390/bios12030138

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Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective cohort

Authors: Sakir Ahmed, Pankti Mehta, Aby Paul, S Anu, Somy Cherian, Veena Shenoy, Kaveri K Nalianda, Sanjana Joseph, Anagha Poulose, Padmanabha Shenoy

Journal: Ann Rheum Dis

PubMed ID: 35135831

Doi: 10.1136/annrheumdis-2021-221922

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PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner

Authors: Minghua Cao, Karol Nawalaniec, Amrendra K Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser

Journal: Transl Oncol

PubMed ID: 35196602

Doi: 10.1016/j.tranon.2022.101377

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Vasoactive Intestinal Peptide Indirectly Elicits Pituitary LH Secretion Independent of GnRH in Female Zebrafish

Authors: Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar

Journal: Endocrinology

PubMed ID: 34978328

Doi: 10.1210/endocr/bqab264

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p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Authors: Chao Ma, Yuhan Li, Yanan Zong, Tony Velkov, Chenxi Wang , Xinyu Yang , Ming Zhang, Zhimin Jiang, Haoran Sun, Qi Tong, Honglei Sun , Juan Pu, Munir Iqbal, Jinhua Liu , Chongshan Dai , Yipeng Sun

Journal: PLoS Pathog

PubMed ID: 35180274

Doi: 10.1371/journal.ppat.1010295

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LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

Authors: Rongze Ma , Difei Gong , Huanyang You , Chongshen Xu , Yunzhe Lu , Gabriele Bergers , Zena Werb , Ophir D Klein , Claudia K Petritsch , Pengfei Lu

Journal: Cell Rep

PubMed ID: 35172155

Doi: 10.1016/j.celrep.2022.110375

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The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance G/G Signaling

Authors: Qiu-Yan Xu, Yong-Jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang

Journal: Front Immunol

PubMed ID: 35296084

Doi: 10.3389/fimmu.2022.818151

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The Secreted Protein PA3611 Promotes Bronchial Epithelial Cell Epithelial-Mesenchymal Transition via Integrin αvβ6-Mediated TGF-β1-Induced p38/NF-κB Pathway Activation

Authors: Lei Shu, Sixia Chen, Shaoqing Lin, Huan Lin, Yan Shao, Jing Yao, Lili Qu, Yunshi Zhang, Xing Liu, Xingran Du, Kaili Deng, Xiaolin Chen, Ganzhu Feng

Journal: Front Microbiol

PubMed ID: 35197937

Doi: 10.3389/fmicb.2021.763749

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Genome-edited powdery mildew resistance in wheat without growth penalties

Authors: Shengnan Li #, Dexing Lin # , Yunwei Zhang # , Min Deng # , Yongxing Chen , Bin Lv , Boshu Li , Yuan Lei , Yanpeng Wang , Long Zhao , Yueting Liang , Jinxing Liu , Kunling Chen , Zhiyong Liu , Jun Xiao , Jin-Long Qiu , Caixia Gao

Journal: Nature

PubMed ID: 35140403

Doi: 10.1038/s41586-022-04395-9

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Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase

Authors: Kaiwen Luo, Yaohui Chen, Fan Wang

Journal: J Immunol

PubMed ID: 35149533

Doi: 10.4049/jimmunol.2100595

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Effect of gastrointestinal alterations mimicking elderly conditions on in vitro digestion of meat and soy proteins

Authors: Chong Wang, Fan Zhao, Yun Bai, Chunbao Li, Xinglian Xu, Karsten Kristiansen, Guanghong Zhou

Journal: Food chemistry

Doi: 10.1016/j.foodchem.2022.132465

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CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Authors: Yiru Long , Jianhua Sun , Tian-Zhang Song , Tingting Liu , Feng Tang , Xinxin Zhang, Longfei Ding , Yunqiu Miao , Weiliang Zhu , Xiaoyan Pan , Qi An, Mian Qin , Xiankun Tong , Xionghua Peng , Pan Yu, Peng Zhu , Jianqing Xu , Xiaoyan Zhang , Yachun Zhang , Datao Liu, Ben Chen , Huilin Chen , Leike Zhang , Gengfu Xiao, Jianping Zuo , Wei Tang , Ji Zhou, Heng Li , Zhijian Xu, Hong-Yi Zheng , Xin-Yan Long , Qiuping Qin , Yong Gan , Jin Ren , Wei Huang , Yong-Tang Zheng , Guangyi Jin , Likun Gong

Journal: Cell Discov .

PubMed ID: 35102138

Doi: 10.1038/s41421-021-00370-2

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