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MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Authors: Yan Li, Nianling Yao, Yan Gao, Yunping Wang, Lu Bai, Jia Xu, Haixu Wang

Journal: Bioengineered

PubMed ID: 34637688

Doi: 10.1080/21655979.2021.1987125

Products & Services: Custom DNA/RNA Oligos

Genome-wide identification and expression analysis of ammonium transporter 1 (AMT1) gene family in cassava ( Crantz) and functional analysis of in transgenic

Authors: Youquan Xia, Yindi Liu, Tingting Zhang, Yu Wang, Xingyu Jiang, Yang Zhou

Journal: 3 Biotech

PubMed ID: 34926117

Doi: 10.1007/s13205-021-03070-6

Products & Services: Protein Tools

Immunization with short peptide particles reveals a functional CD8 T-cell neoepitope in a murine renal carcinoma model

Authors: Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott I Abrams, John M L Ebos, Jonathan F Lovell

Journal: J Immunother Cancer

PubMed ID: 34862254

Doi: 10.1136/jitc-2021-003101

Products & Services: Peptide Synthesis

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

Authors: Wei-Shuo Lin, I-Chen Chen, Hui-Chen Chen, Yi-Chien Lee, Suh-Chin Wu

Journal: Front Immunol

PubMed ID: 34925381

Doi: 10.3389/fimmu.2021.795741

Products & Services: Mutagenesis Services

Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Proteins

Authors: Clara L Kielkopf, William Bauer, Ina L Urbatsch

Journal: Cold Spring Harb Protoc

PubMed ID: 34853120

Doi: 10.1101/pdb.prot102228

Products & Services: Proteins, Expression, Isolation and Analysis

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

Authors: Siyu Liu, Jintao Zhang, Zine Eddine Kherraf, Shuya Sun, Xin Zhang, Caroline Cazin, Charles Coutton, Raoudha Zouari, Shuqin Zhao, Fan Hu, Selima Fourati Ben Mustapha, Christophe Arnoult, Pierre F Ray, Mingxi Liu

Journal: Development

PubMed ID: 34792097

Doi: 10.1242/dev.199805

Products & Services: Plasmid DNA Preparation

De novo design of a transcription factor for a progesterone biosensor

Authors: Kun Liu, Yunsen Zhang, Ke Liu, Yunqiu Zhao, Bei Gao, Xinyi Tao, Ming Zhao, Feng-Qing Wang, Dongzhi Wei

Journal: Biosens Bioelectron

PubMed ID: 35134684

Doi: 10.1016/j.bios.2021.113897

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Phylogeny of Leptographium qinlingensis cytochrome P450 genes and transcription levels of six CYPs in response to different nutrition media or terpenoids

Authors: Lulu Dai, Jie Zheng, Jiaqi Ye, Hui Chen

Journal: Arch Microbiol

PubMed ID: 34894279

Doi: 10.1007/s00203-021-02616-9

Products & Services: DNA Sequencing

The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway

Authors: Ping Zhang, Zhiqiang Cui, Shuai Li

Journal: Bioengineered

PubMed ID: 34605740

Doi: 10.1080/21655979.2021.1979914

Products & Services: Mammalian Expression

Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity

Authors: Zhenghai Tang, Dominique Davidson, Rui Li, Ming-Chao Zhong, Jin Qian, Jun Chen, André Veillette

Journal: Cell Rep

PubMed ID: 34910922

Doi: 10.1016/j.celrep.2021.110111

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SlpB Protein Enhances the Probiotic Potential of NCDO 2118 in Colitis Mice Model

Authors: Giovanna A Belo, Bárbara F Cordeiro, Emiliano R Oliveira, Marina P Braga, Sara H da Silva, Bruno G Costa, Flaviano Dos S Martins, Gwénaël Jan, Yves Le Loir, Alfonso Gala-García, Enio Ferreira, Vasco Azevedo, Fillipe L R do Carmo

Journal: Front Pharmacol

PubMed ID: 34987390

Doi: 10.3389/fphar.2021.755825

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Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34893762

Doi: 10.1038/s42003-021-02940-2

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ER proteins decipher the tubulin code to regulate organelle distribution

Authors: Pengli Zheng, Christopher J Obara, Ewa Szczesna, Jonathon Nixon-Abell, Kishore K Mahalingan, Antonina Roll-Mecak, Jennifer Lippincott-Schwartz, Craig Blackstone

Journal: Nature

PubMed ID: 34912111

Doi: 10.1038/s41586-021-04204-9

Products & Services: Mutant Libraries

Multiplexed CRISPR-mediated engineering of protein secretory pathway genes in the thermotolerant methylotrophic yeast Ogataea thermomethanolica

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34941944

Doi: 10.1371/journal.pone.0261754

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A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses

Authors: Xuexue Liu, Yanli Zhang, Wujun Liu, Yefang Li, Jianfei Pan, Yabin Pu, Jianlin Han, Ludovic Orlando, Yuehui Ma, Lin Jiang

Journal: Curr Biol

PubMed ID: 34906355

Doi: 10.1016/j.cub.2021.11.052

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Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)

Authors: Lina You, Haidong Jiang

Journal: Bioengineered

PubMed ID: 34592907

Doi: 10.1080/21655979.2021.1987066

Products & Services: Plasmid DNA Preparation

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Authors: Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng, Yan-Heng Zhou, Qihong Yan, Ling Chen, Guo-Ying Yu, Junbiao Chang, Xia Jin, Jincun Zhao, Xin-Wen Chen, Yong-Tang Zheng, Jian-Hua Wang

Journal: Signal Transduct Target Ther

PubMed ID: 34921131

Doi: 10.1038/s41392-021-00849-0

Products & Services: Proteins, Expression, Isolation and Analysis

Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity

Authors: Alberto Domingo López-Muñoz, Ivan Kosik, Jaroslav Holly, Jonathan W Yewdell

Journal: biorxiv

PubMed ID: 34931195

Doi: 10.1101/2021.12.10.472169

Products & Services: Mammalian Expression

Kinetic Characterization of Human Histone Deacetylase 8 With Medium-Chain Fatty Acyl Lysine

Authors: Harrison Yoo, Gregory A Polsinelli

Journal: Epigenet Insights

PubMed ID: 34917889

Doi: 10.1177/25168657211065685

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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

Authors: Clement A Meseda, Charles B Stauft, Prabhuanand Selvaraj, Christopher Z Lien, Cyntia Pedro, Ivette A Nuñez, Amy M Woerner, Tony T Wang, Jerry P Weir

Journal: npj Vaccines

PubMed ID: 34862398

Doi: 10.1038/s41541-021-00410-8

Products & Services: Proteins, Expression, Isolation and Analysis

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

Authors: Jian Chen, Jun Fan, Zhilu Chen, Miaomiao Zhang, Haoran Peng, Jian Liu, Longfei Ding, Mingbin Liu, Chen Zhao, Ping Zhao, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34873039

Doi: 10.1073/pnas.2111011118

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African Swine Fever Virus cysteine protease pS273R Inhibits Pyroptosis by Non-canonically Cleaving Gasdermin D

Authors: Gaihong Zhao, Tingting Li, Xuemin Liu, Taoqing Zhang, Zhaoxia Zhang, Li Kang, Jie Song, Shijun Zhou, Xin Chen, Xiao Wang, Jiangnan Li, Li Huang, Changyao Li, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: J Biol Chem

PubMed ID: 34890644

Doi: 10.1016/j.jbc.2021.101480

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Structure, mechanism, and inhibition of Hedgehog acyltransferase

Authors: Claire E Coupland, Sebastian A Andrei, T Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A Schwab, Eamon F X Byrne, Els Pardon, Jan Steyaert, Anthony I Magee, Thomas Lanyon-Hogg, Mark S P Sansom, Edward W Tate, Christian Siebold

Journal: Mol Cell

PubMed ID: 34890564

Doi: 10.1016/j.molcel.2021.11.018

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Analysis of CcGASA family members in Citrus clementina (Hort ex Tan) by a genome-wide approach

Authors: Tianli Wu, Yun Zhong, Min Chen, Bo Wu, Ting Wang, Bo Jiang, Guangyan Zhong

Journal: BMC Plant Biol

PubMed ID: 34852791

Doi: 10.1186/s12870-021-03326-6

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Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions

Authors: Charline Mary, Aurélien Fouillen, Pierre Moffatt, Dainelys Guadarrama Bello, Rima M Wazen, Daniel Grenier, Antonio Nanci

Journal: Sci Rep

PubMed ID: 34887426

Doi: 10.1038/s41598-021-02661-w

Products & Services: Mammalian Expression

The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity

Authors: Kari H Ecklund, Megan E Bailey, Kelly A Kossen, Carsten K Dietvorst, Charles L Asbury, Steven M Markus

Journal: J Cell Sci

PubMed ID: 34854468

Doi: 10.1242/jcs.258510

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KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Authors: John Fadul, Teresa Zulueta-Coarasa, Gloria M Slattum, Nadja M Redd, Mauricio Franco Jin, Michael J Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt

Journal: Nat Commun

PubMed ID: 34893591

Doi: 10.1038/s41467-021-27513-z

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RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors

Authors: Alexander Kuzin, Brendan Redler, Jaya Onuska, Alexei Slesarev

Journal: Sci Rep

PubMed ID: 34880355

Doi: 10.1038/s41598-021-03160-8

Products & Services: Mammalian Expression

Structural insights into Ubr1-mediated N-degron polyubiquitination

Authors: Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu, Minglei Zhao

Journal: Nature.

PubMed ID: 34789879

Doi: 10.1038/s41586-021-04097-8

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EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Mol Cancer

PubMed ID: 34856977

Doi: 10.1186/s12943-021-01456-x

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Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway

Authors: Baorong Jiang, Gehui Yuan, Jialin Wu, Qian Wu, Lei Li, Ping Jiang

Journal: Biochim Biophys Acta Mol Basis Dis

Doi: 10.1016/j.bbadis.2021.166320

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Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes

Authors: Ziyi Guo, Xunjin Zeng, Yu Zheng

Journal: Bioengineered

PubMed ID: 34787067

Doi: 10.1080/21655979.2021.2005895

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ axis

Authors: Xiaohui Lu, Haijie Gao, Bo Zhu, Guilan Lin

Journal: Bioengineered

PubMed ID: 34546853

Doi: 10.1080/21655979.2021.1964157

Products & Services: DNA Sequencing

The Retropepsin-Type Protease APRc as a Novel Ig-Binding Protein and Moonlighting Immune Evasion Factor of

Authors: Pedro Curto, Andreia Barro, Carla Almeida, Ricardo S Vieira-Pires, Isaura Simões

Journal: MBio

PubMed ID: 34872352

Doi: 10.1128/mBio.03059-21

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The WalR-WalK signaling pathway modulates the activities of both CwlO and LytE through control of the peptidoglycan deacetylase PdaC in

Authors: Genevieve S Dobihal, Josué Flores-Kim, Ian J Roney, Xindan Wang, David Z Rudner

Journal: J Bacteriol

PubMed ID: 34871030

Doi: 10.1128/JB.00533-21

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Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci

Authors: Hongming Dong, Yaolei Zhang, Jiahao Wang, Haitao Xiang, Tianhang Lv, Likun Wei, Shaosen Yang, Xiaopan Liu, Bingzhao Ren, Xiuqing Zhang, Lirong Liu, Jun Cao, Meiniang Wang, Jiahai Shi, Naibo Yang

Journal: J Immunol

PubMed ID: 34880108

Doi: 10.4049/jimmunol.2100844

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Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins

Authors: Fatemeh Haghayegh, Razieh Salahandish, Azam Zare, Mahmood Khalghollah, Amir Sanati-Nezhad

Journal: Lab Chip

PubMed ID: 34860233

Doi: 10.1039/d1lc00879j

Products & Services: Proteins, Expression, Isolation and Analysis

Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis

Authors: Zachary G Beamer, Pratyush Routray, Won-Gyu Choi, Margaret K Spangler, Ansul Lokdarshi, Daniel M Roberts

Journal: Plant Physiol

PubMed ID: 34890456

Doi: 10.1093/plphys/kiab196

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Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

Authors: Nadia E Aikawa, Leonard V K Kupa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Emily F N Yuki, Carla G S Saad, Tatiana Pedrosa, Ricardo Fuller, Samuel K Shinjo, Percival D Sampaio-Barros, Danieli C O Andrade, Rosa M R Pereira, Luciana P C Seguro, Juliana M L Valim, Filipe Waridel, Ana Marli C Sartori, Alberto J S Duarte, Leila Antonangelo, Ester C Sabino, Paulo Rossi Menezes, Esper G Kallas, Clovis A Silva, Eloisa Bonfa

Journal: Lancet Rheumatol

PubMed ID: 34901885

Doi: 10.1016/S2665-9913(21)00327-1

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Cleavage-Free Human Genome Editing

Authors: Chenzhong Kuang, Yan Xiao, Dirk Hondmann

Journal: Mol Ther

PubMed ID: 34864205

Doi: 10.1016/j.ymthe.2021.12.001

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Aquaporin expression and cholesterol content in eel swimbladder tissue

Authors: Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P Cutler, Bernd Pelster

Journal: J Fish Biol

PubMed ID: 34882794

Doi: 10.1111/jfb.14973

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Novel Variations in the Gene Causing X-Linked Intellectual Disability

Authors: Po-Ming Wu, Wen-Hao Yu, Chi-Wu Chiang, Chen-Yu Wu, Jia-Shing Chen, Yi-Fang Tu

Journal: Neurol Genet

PubMed ID: 34877407

Doi: 10.1212/NXG.0000000000000646

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FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Authors: Wenlu Fan, Xiaoye Jin, Man Xu, Yongmei Xi, Weiguo Lu, Xiaohang Yang, Min-Xin Guan, Wanzhong Ge

Journal: Nucleic Acids Res

PubMed ID: 34878141

Doi: 10.1093/nar/gkab1187

Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Authors: Brandon M Lane, Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C Middleton, Kinsie Huggins, Amika Sood, Alejandro Ochoa, Andrew F Malone, Ricardo Vancini, Sara E Miller, Gentzon Hall, So Young Kim, David N Howell, Jameela A Kari, Rasheed Gbadegesin

Journal: JCI Insight

PubMed ID: 34874915

Doi: 10.1172/jci.insight.152102

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The large nonstructural protein (NS1) of the human bocavirus 1 (HBoV1) directly interacts with Ku70, which plays an important role in virus replication in human airway epithelia

Authors: Liting Shao, Kang Ning, Jianke Wang, Fang Cheng, Shengqi Wang, Jianming Qiu

Journal: J Virol

PubMed ID: 34878919

Doi: 10.1128/JVI.01840-21

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins

Authors: Jieping Deng , Junping Pan, Minghui Qiu, Lipeng Mao , Zhigang Wang , Guodong Zhu , Lijuan Gao , Jun Su , Yutian Hu , Oscar Junhong Luo , Guobing Chen , Pengcheng Wang

Journal: J Leukoc Biol

PubMed ID: 34231935

Doi: 10.1002/JLB.4MA0621-020R

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Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice

Authors: Wenjuan Li , Xingxing Li , Danhua Zhao , Jingjing Liu , Ling Wang , Miao Li , Xinyu Liu , Jia Li , Xiaohong Wu , Yuhua Li

Journal: Signal Transduct Target Ther

PubMed ID: 34903732

Doi: 10.1038/s41392-021-00843-6

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Nano-immobilization of PETase enzyme for enhanced polyethylene terephthalate biodegradation

Authors: Yunpu Jia , Nadia A. Samak , Xuemi Hao , Zheng Chen , Gama Yang , Xuhao Zhao , Tingzhen Mu , Maohua Yang , Jianmin Xing

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2021.108205

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Cell-Penetrating Antimicrobial Peptides Derived from an Atypical Staphylococcal δ-Toxin

Authors: Kathyana Deeyagahage, Antonio Ruzzini

Journal: Microbiol Spectr

PubMed ID: 34937169

Doi: 10.1128/spectrum.01584-21

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SARS-CoV-2 prevalence and immunity: a hospital-based study from Malawi

Authors: C Meinus, R Singer, B Nandi, O Jagot, B Becker-Ziaja, B Karo, B Mvula, A Jansen, J Baumann, A Schultz

Journal: Int J Infect Dis

PubMed ID: 34929356

Doi: 10.1016/j.ijid.2021.12.336

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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children

Authors: Eder Gatti Fernandes, Giselle Ibette Silva López-Lopes, Valeria Oliveira Silva, Rosemeire Yamashiro, Karen Cristina Rolim Madureira, Juliana Failde Gallo, José Angelo Lindoso, Helena Keico Sato, Núbia Virginia D'Avila Limeira de Araujo, Maria Ligia Bacciotte Ramos Nerger, Luis Fernando Macedo Brigido

Journal: Rev Inst Med Trop Sao Paulo

PubMed ID: 34878041

Doi: 10.1590/S1678-9946202163083

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Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1

Authors: Wenliang Song, Tiening Zhang, Ni Yang, Tao Zhang, Ri Wen, Chunfeng Liu

Journal: Bioengineered

PubMed ID: 34002676

Doi: 10.1080/21655979.2021.1926201

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Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases

Authors: Bruno Gualano, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J Pinto, Bruna C Mazzolani, Fabiana I Smaira, Sofia M Sieczkowska, Nadia E Aikawa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuk, Clovis A Silva, Paul Swinton, Pedro C Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Brain Behav Immun

PubMed ID: 34954325

Doi: 10.1016/j.bbi.2021.12.016

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ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit

Authors: Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luis Vázquez-Ibar

Journal: Emerg Microbes Infect

PubMed ID: 33372863

Doi: 10.1080/22221751.2020.1870413

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Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study

Authors: Hyun Jin Kim, Heon Jeong Yun, Jungok Kim, Sungmin Kym, Qute Choi

Journal: Vaccine

PubMed ID: 34953606

Doi: 10.1016/j.vaccine.2021.12.012

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Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Authors: Lorenzo Azzi, Daniela Dalla Gasperina, Giovanni Veronesi, Mariam Shallak, Giuseppe Ietto, Domenico Iovino, Andreina Baj, Francesco Gianfagna, Vittorio Maurino, Daniele Focosi, Fabrizio Maggi, Marco Mario Ferrario, Francesco Dentali, Giulio Carcano, Angelo Tagliabue, Lorenzo Stefano Maffioli, Roberto Sergio Accolla, Greta Forlani

Journal: EBioMedicine

PubMed ID: 34954658

Doi: 10.1016/j.ebiom.2021.103788

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Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method

Authors: Dafu Zhu, Haixia Su, Changqiang Ke, Chunping Tang, Matthias Witt, Ronald J Quinn, Yechun Xu, Jia Liu, Yang Ye

Journal: J Pharm Biomed Anal

PubMed ID: 34929567

Doi: 10.1016/j.jpba.2021.114538

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Gene-specific quantification of nascent transcription following targeted degradation of endogenous proteins in cultured cells

Authors: Alissa D Guarnaccia, April M Weissmiller, William P Tansey

Journal: STAR Protoc

PubMed ID: 34917979

Doi: 10.1016/j.xpro.2021.101000

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Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer

Authors: Jie Wang, Chen Zhang

Journal: Bioengineered

PubMed ID: 33682613

Doi: 10.1080/21655979.2021.1890377

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Generation and utility of a single-chain fragment variable monoclonal antibody platform against a baculovirus expressed recombinant receptor binding domain of SARS-CoV-2 spike protein

Authors: Reda Salem, Alaa A El-Kholy, Fatma R Waly, Dalia Ayman, Aya Sakr, Mai Hussein

Journal: Mol Immunol

PubMed ID: 34915268

Doi: 10.1016/j.molimm.2021.12.006

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Deep mutational scanning for therapeutic antibody engineering

Authors: Kyrin R Hanning, Mason Minot, Annmaree K Warrender, William Kelton, Sai T Reddy

Journal: Trends Pharmacol Sci

PubMed ID: 34895944

Doi: 10.1016/j.tips.2021.11.010

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Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients

Authors: Serge Ouoba, Mafumi Okimoto, Shintaro Nagashima, Yoshihiro Kitahara, Kei Miwata, Ko Ko, Bunthen E, Aya Sugiyama, Kazuaki Takahashi, Takemasa Sakaguchi, Toshiro Takafuta, Junko Tanaka

Journal: J Med Virol

PubMed ID: 34897741

Doi: 10.1002/jmv.27518

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A Pathogen-Inducible Rice NAC Transcription Factor ONAC096 Contributes to Immunity Against and pv by Direct Binding to the Promoters of , Magnaprothe oryzae, and Xanthomonas oryzaeoryzae OsRap26 OsWRKY62 OsPAL1

Authors: Hui Wang, Yan Bi, Yizhou Gao, Yuqing Yan, Xi Yuan, Xiaohui Xiong, Jiajing Wang, Jiayu Liang, Dayong Li, Fengming Song

Journal: Front Plant Sci

PubMed ID: 34956298

Doi: 10.3389/fpls.2021.802758

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Novel sequential immunocapture microflow LC/MS/MS approach to measuring PTH-Fc protein in human serum

Authors: Haixing Wang, Jiang Wu, Peng Pan, Thuy Nguyen, Michael Cwik, Ling Morgan

Journal: Bioanalysis

PubMed ID: 34894717

Doi: 10.4155/bio-2021-0233

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Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

Authors: Marie-Claude Gaudreau, Radhika R Gudi, Gongbo Li, Benjamin M Johnson, Chenthamarakshan Vasu

Journal: Autoimmunity

PubMed ID: 34882054

Doi: 10.1080/08916934.2021.2012165

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Cryopreservation of network bioactivity and multi-lineage stromal cell differentiation potential within three-dimensional synthetic hydrogels

Authors:

Journal: Cryobiology

PubMed ID: 34922883

Doi: 10.1016/j.cryobiol.2021.12.003

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Structural Insight into the Mechanism of PALB2 Interaction with MRG15

Authors: Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

Journal: Genes (Basel)

PubMed ID: 34946951

Doi: 10.3390/genes12122002

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MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells

Authors: Siyuan Gao, Jing Zhao, Qinglei Xu, Yanli Guo, Mingzheng Liu, Chunlei Zhang, Allan P Schinckel, Bo Zhou

Journal: Theriogenology

PubMed ID: 34959084

Doi: 10.1016/j.theriogenology.2021.12.014

Products & Services: Proteins, Expression, Isolation and Analysis

The impact of benzo[a]pyrene on murine allergic airway inflammation via epigenetic remodeling

Authors: Xihua Wang, Shuyuan Guan, Lingbin Sun, Zhongliang Dai

Journal: Environ Toxicol Pharmacol

PubMed ID: 34883242

Doi: 10.1016/j.etap.2021.103782

Products & Services: Proteins, Expression, Isolation and Analysis

Adenovirus-mediated RNA interference against herpes simplex virus infection in vitro

Authors: Lin Chen, Zhi-Qiang Pan, Chang-Bin Zhai

Journal: Folia Histochem Cytobiol

PubMed ID: 34905214

Doi: 10.5603/FHC.a2021.0031

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Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men

Authors: Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu, Biauw Chi Ong

Journal: Emerg Microbes Infect

PubMed ID: 34709140

Doi: 10.1080/22221751.2021.1999777

Convergent phenotypic evolution of rhodopsin for dim-light sensing across deep-diving vertebrates

Authors: Yu Xia , Yimeng Cui , Aishan Wang , Fangnan Liu , Hai Chi , Joshua H T Potter , Joseph Williamson , Xiaolan Chen , Stephen J Rossiter , Yang Liu

Journal: Mol Biol Evol

PubMed ID: 34463769

Doi: 10.1093/molbev/msab262

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Nanopore-based measurement of the interaction of P450cam monooxygenase and putidaredoxin at the single-molecule level

Authors: Hui Chen, Yao Lin, Yi-Tao Long, Shelley D Minteer, Yi-Lun Ying

Journal: Faraday Discuss

PubMed ID: 34889330

Doi: 10.1039/d1fd00042j

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Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Authors: Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi

Journal: Biomedicines

PubMed ID: 34944698

Doi: 10.3390/biomedicines9121882

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Synergistic enzyme cocktail between levansucrase and inulosucrase for superb levan-type fructooligosaccharide synthesis

Authors: Karan Wangpaiboon, Methus Klaewkla, Thanapon Charoenwongpaiboon, Napas Vongkusolkit, Pawinee Panpetch, Kamontip Kuttiyawong, Wonnop Visessanguan, Rath Pichyangkura

Journal: Enzyme Microb Technol

PubMed ID: 34923315

Doi: 10.1016/j.enzmictec.2021.109960

Products & Services: Proteins, Expression, Isolation and Analysis

Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding

Authors: Lori I Robins, Erika K Keim, Deborah B Robins, John S Edgar, John S Meschke, Philip R Gafken, Jeffrey F Williams

Journal: ACS Omega

PubMed ID: 34984290

Doi: 10.1021/acsomega.1c05297

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Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides

Authors: Francesca Troilo, Marco Pedretti, Carlo Travaglini-Allocatelli, Alessandra Astegno, Adele Di Matteo

Journal: Biochem Biophys Res Commun

PubMed ID: 34974297

Doi: 10.1016/j.bbrc.2021.12.077

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An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

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Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

Products & Services: Proteins, Expression, Isolation and Analysis

COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer

Authors: Cong Zeng, John P Evans, Karthik Chakravarthy, Panke Qu, Sarah Reisinger, No-Joon Song, Mark P Rubinstein, Peter G Shields, Zihai Li, Shan-Lu Liu

Journal: Cancer Cell

PubMed ID: 34986328

Doi: 10.1016/j.ccell.2021.12.014

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A metabolic labeling protocol to enrich myristoylated proteins from

Authors: Xin Gong, Yanwen Feng, Hongyun Tang

Journal: STAR Protoc

PubMed ID: 34917984

Doi: 10.1016/j.xpro.2021.101013

Products & Services: Proteins, Expression, Isolation and Analysis

BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

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A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

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A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

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Safety evaluation of the mouse TCRα - transduced T cell product in preclinical models in vivo and in vitro

Authors: Anastasiia Kalinina, Alexandra Bruter, Nadezhda Persiyantseva, Yulia Silaeva, Maria Zamkova, Ludmila Khromykh, Dmitry Kazansky

Journal: Biomed Pharmacother

PubMed ID: 34915667

Doi: 10.1016/j.biopha.2021.112480

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Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients: A Randomized Clinical Trial

Authors: Roman Reindl-Schwaighofer, Andreas Heinzel, Manuel Mayrdorfer, Rhea Jabbour, Thomas M Hofbauer, Anne Merrelaar, Michael Eder, Florina Regele, Konstantin Doberer, Paul Spechtl, Constantin Aschauer, Maximilian Koblischke, Christopher Paschen, Farsad Eskandary, Karin Hu, Barbara Öhler, Arshdeep Bhandal, Sabine Kleibenböck, Rahel I Jagoditsch, Bianca Reiskopf, Florian Heger, Gregor Bond, Georg A Böhmig, Robert Strassl, Lukas Weseslindtner, Alexander Indra, Judith H Aberle, Michael Binder, Rainer Oberbauer

Journal: JAMA Intern Med

PubMed ID: 34928302

Doi: 10.1001/jamainternmed.2021.7372

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Bio inspired growth factor loaded self assembling peptide nano hydrogel for chronic wound healing

Authors: E Santhini, R Parthasarathy, M Shalini, S Dhivya, L Amalorpava Mary, V Vijaya Padma

Journal: Int J Biol Macromol

PubMed ID: 34920072

Doi: 10.1016/j.ijbiomac.2021.12.026

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Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

Authors: Nai-Hsiang Chung, Ying-Chin Chen, Shiu-Ju Yang, Yu-Ching Lin, Horng-Yunn Dou, Lily Hui-Ching Wang, Ching-Len Liao, Yen-Hung Chow

Journal: Vaccine

PubMed ID: 34952759

Doi: 10.1016/j.vaccine.2021.12.024

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SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

Authors: Laís Teodoro da Silva, Marina Mazzilli Ortega, Bruna Tiaki Tiyo, Isabelle Freire Tabosa Viana, Tayná Evily de Lima, Tania Regina Tozetto-Mendoza, Luanda Mara da Silva Oliveira, Franciane Mouradian Emidio Teixeira, Roberto Dias Lins, Alexandre de Almeida, Maria Cassia Mendes-Correa, Alberto Jose da Silva Duarte, Telma Miyuki Oshiro

Journal: Clinics (Sao Paulo)

PubMed ID: 34878034

Doi: 10.6061/clinics/2021/e3548

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Porcine Genome-Wide CRISPR Screen Identifies the Golgi Apparatus Complex Protein COG8 as a Pivotal Regulator of Influenza Virus Infection

Authors: Ao Zhou, Wenhua Zhang, Xia Dong, Bin Tang

Journal: CRISPR J

PubMed ID: 34935491

Doi: 10.1089/crispr.2021.0054

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Anisotropic Rod-Shaped Particles Influence Injectable Granular Hydrogel Properties and Cell Invasion

Authors: Taimoor H Qazi, Jingyu Wu, Victoria G Muir, Shoshana Weintraub, Sarah E Gullbrand, Daeyeon Lee, David Issadore, Jason A Burdick

Journal: Adv Mater

PubMed ID: 34932833

Doi: 10.1002/adma.202109194

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Development of competitive and noncompetitive immunoassays for clothianidin with high sensitivity and specificity using phage-displayed peptides

Authors: Tianyang You, Yuan Ding, He Chen, Guangyue Song, Lianrun Huang, Minghua Wang, Xiude Hua

Journal: J Hazard Mater

PubMed ID: 34896720

Doi: 10.1016/j.jhazmat.2021.128011

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A New Testing Platform Using Fingerstick Blood for Quantitative Antibody Response Evaluation after SARS-CoV-2 Vaccination

Authors: Jinwei Du, Dayu Zhang, Joseph A Pathakamuri, Daniel Kuebler, Ying Yang, Yulia Loginova, Eric Chu, Roberta Madej, Jocelyn V Neves, Brianna Singer, Holly Radke, Naomi Spencer, Elizabeth Rizk, Aiguo Zhang, Chuanyi M Lu, Michael Y Sha

Journal: Emerg Microbes Infect

PubMed ID: 34951566

Doi: 10.1080/22221751.2021.2023328

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Rapid directed molecular evolution of fluorescent proteins in mammalian cells

Authors: Siranush Babakhanova, Erica E Jung, Kazuhiko Namikawa, Hanbin Zhang, Yangdong Wang, Oksana M Subach, Dmitry A Korzhenevskiy, Tatiana V Rakitina, Xian Xiao, Wenjing Wang, Jing Shi, Mikhail Drobizhev, Demian Park, Lea Eisenhard, Hongyun Tang, Reinhard W Köster, Fedor V Subach, Edward S Boyden, Kiryl D Piatkevich

Journal: Protein Sci

PubMed ID: 34913537

Doi: 10.1002/pro.4261

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Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB

Authors: Xiuyuan Lu, Masatsugu Oh-Hora, Kiyoshi Takeda, Sho Yamasaki

Journal: Int Immunol

PubMed ID: 34953165

Doi: 10.1093/intimm/dxab112

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Simplified Point-of-Care Full SARS-CoV-2 Genome Sequencing Using Nanopore Technology

Authors: Anton Pembaur, Erwan Sallard, Patrick Philipp Weil, Jennifer Ortelt, Parviz Ahmad-Nejad, Jan Postberg

Journal: Microorganisms

PubMed ID: 34946199

Doi: 10.3390/microorganisms9122598

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Rhomboid-like Protein 5 Provided Partial Protection against Homologous Challenge in Forms of Recombinant Protein and DNA Plasmid in Chickens

Authors: Di Tian, Xiaoqian Liu, Xiangrui Li, Lixin Xu, Ruofeng Yan, Xiaokai Song

Journal: Vaccines (Basel)

PubMed ID: 35062693

Doi: 10.3390/vaccines10010032

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Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors

Authors: Viacheslav V Senichkin, Nikolay V Pervushin, Alexey V Zamaraev, Elena V Sazonova, Anton P Zuev, Alena Y Streletskaia, Tatiana A Prikazchikova, Timofei S Zatsepin, Olga V Kovaleva, Elena M Tchevkina, Boris Zhivotovsky, Gelina S Kopeina

Journal: Cancers (Basel)

PubMed ID: 35008345

Doi: 10.3390/cancers14010181

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