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Engineering Ligand and Receptor Pairs with LIPSTIC to Track Cell-Cell Interactions

Authors: Dafne Alberti, Michelle Guarniero, Agnieszka K Maciola, Enrico Dotta, Giulia Pasqual

Journal: Curr Protoc

PubMed ID: 34870906

Doi: 10.1002/cpz1.311

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Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Authors:

Journal: Lancet Infect Dis

PubMed ID: 34953520

Doi: 10.1016/S1473-3099(21)00751-9

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Cryptic splicing events result in unexpected protein products from calpain-10 (CAPN10) cDNA

Authors: Yasuko Ono, Naoko Doi, Mayumi Shindo, Pablo Pánico, Ana María Salazar

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 34906616

Doi: 10.1016/j.bbamcr.2021.119188

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 vaccine in patients with systemic sclerosis: Impact of disease subtype and therapy

Authors: Percival Degrava Sampaio-Barros, Ana Cristina Medeiros-Ribeiro, Ana Paula Luppino-Assad, Renata Miossi, Henrique Carriço da Silva, Emily F V N Yuki, Sandra G Pasoto, Carla G S Saad, Clóvis A Silva, Léonard V K Kupa, Giordano B H Deveza, Tatiana N Pedrosa, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34894235

Doi: 10.1093/rheumatology/keab886

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

Authors: Kimberly Nellenbach, Alexander Kyu, Nina Guzzetta, Ashley C Brown

Journal: Blood Adv

PubMed ID: 34555851

Doi: 10.1182/bloodadvances.2021004417

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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Authors: Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Cathrine Knetter, Mete Can Odabasi, Ravi Chand Bollineni, Xinbo Yang, Zsofia Foldvari, Maxi-Lu Böschen, Eli Taraldsrud, Erlend Strønen, Mireille Toebes, Amy Hillen, Stefania Mazzi, Arnoud H de Ru, George M C Janssen, Arne Kolstad, Geir Erland Tjønnfjord, Benedicte A Lie, Marieke Griffioen, Sören Lehmann, Liv Toril Osnes, Jochen Buechner, K Christopher Garcia, Ton N Schumacher, Peter A van Veelen, Matthias Leisegang, Sten Eirik W Jacobsen, Petter Woll, Johanna Olweus

Journal: Nat Biotechno.

PubMed ID: 34873326

Doi: 10.1038/s41587-021-01089-x

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Increased SERPINA3 Level Is Associated with Ulcerative Colitis

Authors: Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen

Journal: Diagnostics (Basel)

PubMed ID: 34943607

Doi: 10.3390/diagnostics11122371

Products & Services: Recombinant Proteins

Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

Authors: Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, and Moutih Rafe

Journal: Cell Reports Medicine

PubMed ID: 35028603

Doi: 10.1016/j.xcrm.2021.100455

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An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility

Authors: Abhishek Das, Satarupa Dutta, Dewanshu Sharma, Amit Pal, Nirmalya Ganguli, Subeer S Majumdar

Journal: Bioengineered

PubMed ID: 34436976

Doi: 10.1080/21655979.2021.1955509

Products & Services: PCR Cloning and Subcloning

Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM

Authors: Fuji Lai, Huiqin Zhang, Binbin Xu, Yangyang Xie, Hua Yu

Journal: Bioengineered

PubMed ID: 34506209

Doi: 10.1080/21655979.2021.1958558

Products & Services: PCR and Cloning

Study protocol for a randomised clinical trial of a decision aid and values clarification method for parents of a fetus or neonate diagnosed with a life-threatening congenital heart defect

Authors: Rebecca K Delaney, Nelangi M Pinto, Elissa M Ozanne, Louisa A Stark, Mandy L Pershing, Alistair Thorpe, Holly O Witteman, Praveen Thokala, Linda M Lambert, Lisa M Hansen, Tom H Greene, Angela Fagerlin

Journal: BMJ Open

PubMed ID: 34893487

Doi: 10.1136/bmjopen-2021-055455

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Analysis of Immunoreactivity of α/α-Tropomyosin from , Based on IgE Epitopes and Structural Characteristics

Authors: Nai-Ru Ji, Xin-Yu Han, Chen-Chen Yu, Yu-Jia Wang, Xin-Rong He, Hong Liu, Fei Huan, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: J Agric Food Chem

PubMed ID: 34881872

Doi: 10.1021/acs.jafc.1c06401

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Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity

Authors: Meng-Meng Chen, Si-Ru Yang, Jian Wang, Ya-Li Fang, You-Liang Peng, Jun Fan

Journal: J Exp Bot

PubMed ID: 34864987

Doi: 10.1093/jxb/erab530

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In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion

Authors: Xiaocui Li, Min An, Zhenjun Gao

Journal: J Oncol

PubMed ID: 34899909

Doi: 10.1155/2021/7430468

Products & Services: Proteins, Expression, Isolation and Analysis

Lysine β-Hydroxybutyrylation Improves Stability of COVID-19 Antibody

Authors: Zihua Li, Yudian Zhang, Meng Han, Haiteng Deng, Fuqing Wu, Gang Liu, Guo-Qiang Chen

Journal: Biomacromolecules

PubMed ID: 34879647

Doi: 10.1021/acs.biomac.1c01435

Products & Services: Proteins, Expression, Isolation and Analysis

Novel carotenogenic gene combinations from red yeasts enhanced lycopene and beta-carotene production in Saccharomyces cerevisiae from the low-cost substrate sucrose

Authors: Akaraphol Watcharawipas, Kitisak Sansatchanon, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Weerawat Runguphan, Kanokarn Kocharin

Journal: FEMS Yeast Res

PubMed ID: 34865010

Doi: 10.1093/femsyr/foab062

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Different response of Acipenser gueldenstaedtii CRP/SAP and SAA to bacterial challenge and chronic thermal stress sheds light on the innate immune system of sturgeons

Authors: Marcio Aversa-Marnai, Mauricio Castellano, Ignacio Quartiani, Daniel Conijesky, Alejandro Perretta, Andrea Villarino, Valeria Silva-Álvarez, Ana María Ferreira

Journal: Fish Shellfish Immunol

PubMed ID: 34971737

Doi: 10.1016/j.fsi.2021.12.029

Products & Services: Recombinant Proteins

Development of a Highly Sensitive Luciferase-Based Reporter System To Study Two-Step Protein Secretion in Cyanobacteria

Authors: David A Russo, Julie A Z Zedler, Fabian D Conradi, Nils Schuergers, Poul Erik Jensen, Conrad W Mullineaux, Annegret Wilde, Georg Pohnert

Journal: J Bacteriol

PubMed ID: 34898262

Doi: 10.1128/JB.00504-21

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BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

Authors: Qing-Tao Meng, Xian-Yu Liu, Xue-Ting Liu, Juan Liu, Admire Munanairi, Devin M Barry, Benlong Liu, Hua Jin, Yu Sun, Qianyi Yang, Fang Gao, Li Wan, Jiahang Peng, Jin-Hua Jin, Kai-Feng Shen, Ray Kim, Jun Yin, Ailin Tao, Zhou-Feng Chen

Journal: Elife

PubMed ID: 34919054

Doi: 10.7554/eLife.71689

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Characterization of Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-Angle X-ray Scattering (SAXS)

Authors: Tatjana Schamber, Oliver Binas, Andreas Schlundt, Anna Wacker, Harald Schwalbe

Journal: Chembiochem

PubMed ID: 34847270

Doi: 10.1002/cbic.202100564

Products & Services: Plasmid DNA Preparation

Synthesis of Human Bone Morphogenetic Protein-2 (hBMP-2) in Periplasmic Space: Its Characterization and Preclinical Testing

Authors: João E Oliveira, Miriam F Suzuki, Renata Damiani, Eliana R Lima, Kleicy C Amaral, Anderson M S Santos, Geraldo S Magalhães, Leonardo P Faverani, Luís A V D Pereira, Paolo Bartolini

Journal: Cells

PubMed ID: 34944033

Doi: 10.3390/cells10123525

Products & Services: Proteins, Expression, Isolation and Analysis

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

Authors: Kangli Cao, Xiang Wang, Haoran Peng, Longfei Ding, Xiangwei Wang, Yangyang Hu, Lanlan Dong, Tianhan Yang, Xiujing Hong, Man Xing, Duoduo Li, Cuisong Zhu, Xiangchuan He, Chen Zhao, Ping Zhao, Dongming Zhou, Xiaoyan Zhang, Jianqing Xu

Journal: J Virol

PubMed ID: 34908443

Doi: 10.1128/JVI.01578-21

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Silencing an E3 Ubiquitin Ligase Gene OsJMJ715 Enhances the Resistance of Rice to a Piercing-Sucking Herbivore by Activating ABA and JA Signaling Pathways

Authors: Yuebai Zhang , Mengting Chen , Shuxing Zhou , Yonggen Lou , Jing Lu

Journal: Int J Mol Sci

PubMed ID: 34884830

Doi: 10.3390/ijms222313020

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of Mutations Causing CYP21A2 Deficiency in Brazilian and Portuguese Populations

Authors: Mayara J Prado, Shripriya Singh, Rodrigo Ligabue-Braun, Bruna V Meneghetti, Thaiane Rispoli, Cristiane Kopacek, Karina Monteiro, Arnaldo Zaha, Maria L R Rossetti, Amit V Pandey

Journal: Int J Mol Sci

PubMed ID: 35008721

Doi: 10.3390/ijms23010296

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Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway

Authors: Kelan Yuan, Jiao Zheng, Xiao Shen, Yaying Wu, Yu Han, Xiuming Jin, Xiaodan Huang

Journal: Int Immunopharmacol

PubMed ID: 34906854

Doi: 10.1016/j.intimp.2021.108426

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting cIAPs attenuates CCl-induced liver fibrosis by increasing MMP9 expression derived from neutrophils

Authors: Yi Wu, Suwen Lu, Xuan Huang, Yuanyuan Liu, Kuiyuan Huang, Ziying Liu, Weikang Xu, Wei Zhu, Jinlin Hou, Hongyan Liu, Xiaoyong Zhang

Journal: Life Sci

PubMed ID: 34914932

Doi: 10.1016/j.lfs.2021.120235

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Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

Products & Services: Proteins, Expression, Isolation and Analysis

GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver

Authors: Leire Goicoechea, Fabian Arenas, Fernanda Castro, Susana Nuñez, Sandra Torres, Carmen Garcia-Ruiz, José C Fernandez-Checa

Journal: STAR Protoc

PubMed ID: 35024626

Doi: 10.1016/j.xpro.2021.101068

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An immunochromatographic assay utilizing magnetic nanoparticles to detect major peanut allergen Ara h 1 in processed foods

Authors: Hsin-Yi Yin, Yi-Ting Li, Wen-Che Tsai, Hong-Yu Dai, Hsiao-Wei Wen

Journal: Food Chem

PubMed ID: 34952385

Doi: 10.1016/j.foodchem.2021.131844

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The key regulator LcERF056 enhances salt tolerance by modulating reactive oxygen species-related genes in Lotus corniculatus

Authors: Dan Wang, Zhanmin Sun, Xinxu Hu, Junbo Xiong, Lizhen Hu, Yuandong Xu, Yixiong Tang, Yanmin Wu

Journal: BMC Plant Biol

PubMed ID: 34965872

Doi: 10.1186/s12870-021-03336-4

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KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3

Authors: Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun

Journal: Int J Mol Sci

PubMed ID: 35008530

Doi: 10.3390/ijms23010104

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Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T‑Cell Epitopes for Cancer Immunotherapy

Authors: Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, and Yumiao Zhang

Journal: Chem. Mater.

Doi: 10.1021/acs.chemmater.1c03681

Products & Services: Peptide Synthesis

Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)

Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller

Journal: Biophys Chem

PubMed ID: 34953381

Doi: 10.1016/j.bpc.2021.106745

Products & Services: Mutagenesis Services

Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers

Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen

Journal: Hum Mutat

PubMed ID: 34923709

Doi: 10.1002/humu.24321

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Critical residues for proteolysis activity of maize chlorotic dwarf virus (MCDV) 3C-like protease and comparison of activity of orthologous waikavirus proteases

Authors: Lucy R Stewart, Matthew Willman, DeeMarie Marty, Anna Emmick Cole, Kristen Willie

Journal: Virology

PubMed ID: 34998226

Doi: 10.1016/j.virol.2021.12.008

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BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

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hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis

Authors: Pei Cao, Bo Ma, Ding Sun, Weigang Zhang, Junyi Qiu, Lei Qin, Xiaofeng Xue

Journal: Cancer Sci

PubMed ID: 34890089

Doi: 10.1111/cas.15238

Products & Services: Mammalian Expression

Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling

Authors: Yingrui Deng, Xiaoting Zhang, Rui Li, Zhuo Li, Boguang Yang, Peng Shi, Honglu Zhang, Chunming Wang, Chunyi Wen, Gang Li, Liming Bian

Journal: Biomaterials

PubMed ID: 34959028

Doi: 10.1016/j.biomaterials.2021.121316

Products & Services: Proteins, Expression, Isolation and Analysis

Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials

Authors: Jill Whitley, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, Hong Liao, Sean Chiou, Tina Marmura, Holly Zoeller, Ben Hudson, John Peart, Monica Johnson, Amelia Karlsson, Yunfei Wang, Cynthia Nagle, Cherell Harris, Daniel Tonkin, Stephanie Fraser, Lieza Capiz, Christina L Zeno, Yvonne Meli, Diana Martik, Daniel A Ozaki, Amy Caparoni, Jason E Dickens, Drew Weissman, Kevin O Saunders, Barton F Haynes, Gregory D Sempowski, Thomas N Denny, Matthew R Johnson

Journal: Transl Res

PubMed ID: 34871810

Doi: 10.1016/j.trsl.2021.11.009

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Authors: Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 34992737

Doi: 10.1080/20002297.2021.2015130

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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

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Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

Authors: Nessma A El-Zawawy, Mahy M Mona

Journal: Sci Rep

PubMed ID: 34934098

Doi: 10.1038/s41598-021-03664-3

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Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

Authors: I-Ting Teng, Alexandra F Nazzari, Misook Choe, Tracy Liu, Matheus Oliveira de Souza, Yuliya Petrova, Yaroslav Tsybovsky, Shuishu Wang, Baoshan Zhang, Mykhaylo Artamonov, Bharat Madan, Aric Huang, Sheila N Lopez Acevedo, Xiaoli Pan, Tracy J Ruckwardt, Brandon J DeKosky, John R Mascola, John Misasi, Nancy J Sullivan, Tongqing Zhou, Peter D Kwong

Journal: biorxiv

PubMed ID: 35018379

Doi: 10.1101/2021.12.29.474491

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Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model

Authors: Gustavo Luis Verón, María Florencia Veiga, Mónica Cameo, Clara Isabel Marín-Briggiler, Mónica Hebe Vazquez-Levin

Journal: Cells

PubMed ID: 35011663

Doi: 10.3390/cells11010102

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Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

Authors: Richard N Day, Kathleen H Day, Fredrick M Pavalko

Journal: PLoS ONE

PubMed ID: 34941939

Doi: 10.1371/journal.pone.0261660

Products & Services: Proteins, Expression, Isolation and Analysis

Single-Dose Vaccination of Recombinant Chimeric Newcastle Disease Virus (NDV) LaSota Vaccine Strain Expressing Infectious Bursal Disease Virus (IBDV) VP2 Gene Provides Full Protection against Genotype VII NDV and IBDV Challenge

Authors: Qilong Qiao, Mingzhen Song, Congcong Song, Yihang Zhang, Xiangdong Wang, Qing Huang, Baiyu Wang, Panpan Yang, Shiyi Zhao, Yongtao Li, Zeng Wang, Jun Zhao

Journal: Vaccines (Basel)

PubMed ID: 34960229

Doi: 10.3390/vaccines9121483

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Tandem mass tag (TMT)-based proteomic analysis of Cryptosporidium andersoni oocysts before and after excystation

Authors: Dong-Fang Li, Zhao-Hui Cui, Lu-Yang Wang, Kai-Hui Zhang, Le-Tian Cao, Shuang-Jian Zheng, Long-Xian Zhang

Journal: Parasit Vectors

PubMed ID: 34922597

Doi: 10.1186/s13071-021-05113-6

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Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Authors: Ru Dong, Cheng Zhang, Chao Wang, Xin Zhou, Wen Li, Jin-Yang Zhang, Min Wang, Yong Xu, Li-Ping Sun

Journal: Bioorg Med Chem

PubMed ID: 34999525

Doi: 10.1016/j.bmc.2021.116592

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ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes

Authors: Jessica M Hong, Michael Gibbons, Ali Bashir, Diana Wu, Shirley Shao, Zachary Cutts, Mariya Chavarha, Ye Chen, Lauren Schiff, Mikelle Foster, Victoria A Church, Llyke Ching, Sara Ahadi, Anna Hieu-Thao Le, Alexander Tran, Michelle Dimon, Marc Coram, Brian Williams, Phillip Jess, Marc Berndl, Annalisa Pawlosky

Journal: iScience

PubMed ID: 35005536

Doi: 10.1016/j.isci.2021.103586

Products & Services: Proteins, Expression, Isolation and Analysis

NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes

Authors: Juan Fan, Jiawei Shi, Yong Zhang, Junwei Liu, Chenyi An, Huaying Zhu, Peng Wu, Wei Hu, Rui Qin, Danmei Yao, Xin Shou, Yibing Xu, Zhou Tong, Xue Wen, Jianpo Xu, Jin Zhang, Weijia Fang, Jizhong Lou, Weiwei Yin, Wei Chen

Journal: EMBO J

PubMed ID: 34913508

Doi: 10.15252/embj.2021107739

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Cloning and Characterization of Two Putative P-Type ATPases from the Marine Microalga Similar to Plant H-ATPases and Their Gene Expression Analysis under Conditions of Hyperosmotic Salt Shock

Authors: Dmitrii A Matalin, Dmitrii E Khramov, Alexey V Shuvalov, Vadim S Volkov, Yurii V Balnokin, Larissa G Popova

Journal: Plants (Basel)

PubMed ID: 34961138

Doi: 10.3390/plants10122667

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Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

Authors: Yifan Ge, Sivakumar Boopathy, Tran H Nguyen, Camila Makhlouta Lugo, Luke H Chao

Journal: Front Mol Biosci

PubMed ID: 35004847

Doi: 10.3389/fmolb.2021.769135

Products & Services: Mammalian Expression

MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Authors: Yan Li, Nianling Yao, Yan Gao, Yunping Wang, Lu Bai, Jia Xu, Haixu Wang

Journal: Bioengineered

PubMed ID: 34637688

Doi: 10.1080/21655979.2021.1987125

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Genome-wide identification and expression analysis of ammonium transporter 1 (AMT1) gene family in cassava ( Crantz) and functional analysis of in transgenic

Authors: Youquan Xia, Yindi Liu, Tingting Zhang, Yu Wang, Xingyu Jiang, Yang Zhou

Journal: 3 Biotech

PubMed ID: 34926117

Doi: 10.1007/s13205-021-03070-6

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Immunization with short peptide particles reveals a functional CD8 T-cell neoepitope in a murine renal carcinoma model

Authors: Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott I Abrams, John M L Ebos, Jonathan F Lovell

Journal: J Immunother Cancer

PubMed ID: 34862254

Doi: 10.1136/jitc-2021-003101

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Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

Authors: Wei-Shuo Lin, I-Chen Chen, Hui-Chen Chen, Yi-Chien Lee, Suh-Chin Wu

Journal: Front Immunol

PubMed ID: 34925381

Doi: 10.3389/fimmu.2021.795741

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Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Proteins

Authors: Clara L Kielkopf, William Bauer, Ina L Urbatsch

Journal: Cold Spring Harb Protoc

PubMed ID: 34853120

Doi: 10.1101/pdb.prot102228

Products & Services: Proteins, Expression, Isolation and Analysis

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

Authors: Siyu Liu, Jintao Zhang, Zine Eddine Kherraf, Shuya Sun, Xin Zhang, Caroline Cazin, Charles Coutton, Raoudha Zouari, Shuqin Zhao, Fan Hu, Selima Fourati Ben Mustapha, Christophe Arnoult, Pierre F Ray, Mingxi Liu

Journal: Development

PubMed ID: 34792097

Doi: 10.1242/dev.199805

Products & Services: Plasmid DNA Preparation

De novo design of a transcription factor for a progesterone biosensor

Authors: Kun Liu, Yunsen Zhang, Ke Liu, Yunqiu Zhao, Bei Gao, Xinyi Tao, Ming Zhao, Feng-Qing Wang, Dongzhi Wei

Journal: Biosens Bioelectron

PubMed ID: 35134684

Doi: 10.1016/j.bios.2021.113897

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Phylogeny of Leptographium qinlingensis cytochrome P450 genes and transcription levels of six CYPs in response to different nutrition media or terpenoids

Authors: Lulu Dai, Jie Zheng, Jiaqi Ye, Hui Chen

Journal: Arch Microbiol

PubMed ID: 34894279

Doi: 10.1007/s00203-021-02616-9

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The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway

Authors: Ping Zhang, Zhiqiang Cui, Shuai Li

Journal: Bioengineered

PubMed ID: 34605740

Doi: 10.1080/21655979.2021.1979914

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Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity

Authors: Zhenghai Tang, Dominique Davidson, Rui Li, Ming-Chao Zhong, Jin Qian, Jun Chen, André Veillette

Journal: Cell Rep

PubMed ID: 34910922

Doi: 10.1016/j.celrep.2021.110111

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SlpB Protein Enhances the Probiotic Potential of NCDO 2118 in Colitis Mice Model

Authors: Giovanna A Belo, Bárbara F Cordeiro, Emiliano R Oliveira, Marina P Braga, Sara H da Silva, Bruno G Costa, Flaviano Dos S Martins, Gwénaël Jan, Yves Le Loir, Alfonso Gala-García, Enio Ferreira, Vasco Azevedo, Fillipe L R do Carmo

Journal: Front Pharmacol

PubMed ID: 34987390

Doi: 10.3389/fphar.2021.755825

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Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34893762

Doi: 10.1038/s42003-021-02940-2

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ER proteins decipher the tubulin code to regulate organelle distribution

Authors: Pengli Zheng, Christopher J Obara, Ewa Szczesna, Jonathon Nixon-Abell, Kishore K Mahalingan, Antonina Roll-Mecak, Jennifer Lippincott-Schwartz, Craig Blackstone

Journal: Nature

PubMed ID: 34912111

Doi: 10.1038/s41586-021-04204-9

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Multiplexed CRISPR-mediated engineering of protein secretory pathway genes in the thermotolerant methylotrophic yeast Ogataea thermomethanolica

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34941944

Doi: 10.1371/journal.pone.0261754

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A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses

Authors: Xuexue Liu, Yanli Zhang, Wujun Liu, Yefang Li, Jianfei Pan, Yabin Pu, Jianlin Han, Ludovic Orlando, Yuehui Ma, Lin Jiang

Journal: Curr Biol

PubMed ID: 34906355

Doi: 10.1016/j.cub.2021.11.052

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Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)

Authors: Lina You, Haidong Jiang

Journal: Bioengineered

PubMed ID: 34592907

Doi: 10.1080/21655979.2021.1987066

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SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Authors: Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng, Yan-Heng Zhou, Qihong Yan, Ling Chen, Guo-Ying Yu, Junbiao Chang, Xia Jin, Jincun Zhao, Xin-Wen Chen, Yong-Tang Zheng, Jian-Hua Wang

Journal: Signal Transduct Target Ther

PubMed ID: 34921131

Doi: 10.1038/s41392-021-00849-0

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Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity

Authors: Alberto Domingo López-Muñoz, Ivan Kosik, Jaroslav Holly, Jonathan W Yewdell

Journal: biorxiv

PubMed ID: 34931195

Doi: 10.1101/2021.12.10.472169

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Kinetic Characterization of Human Histone Deacetylase 8 With Medium-Chain Fatty Acyl Lysine

Authors: Harrison Yoo, Gregory A Polsinelli

Journal: Epigenet Insights

PubMed ID: 34917889

Doi: 10.1177/25168657211065685

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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

Authors: Clement A Meseda, Charles B Stauft, Prabhuanand Selvaraj, Christopher Z Lien, Cyntia Pedro, Ivette A Nuñez, Amy M Woerner, Tony T Wang, Jerry P Weir

Journal: npj Vaccines

PubMed ID: 34862398

Doi: 10.1038/s41541-021-00410-8

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Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

Authors: Jian Chen, Jun Fan, Zhilu Chen, Miaomiao Zhang, Haoran Peng, Jian Liu, Longfei Ding, Mingbin Liu, Chen Zhao, Ping Zhao, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34873039

Doi: 10.1073/pnas.2111011118

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African Swine Fever Virus cysteine protease pS273R Inhibits Pyroptosis by Non-canonically Cleaving Gasdermin D

Authors: Gaihong Zhao, Tingting Li, Xuemin Liu, Taoqing Zhang, Zhaoxia Zhang, Li Kang, Jie Song, Shijun Zhou, Xin Chen, Xiao Wang, Jiangnan Li, Li Huang, Changyao Li, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: J Biol Chem

PubMed ID: 34890644

Doi: 10.1016/j.jbc.2021.101480

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Structure, mechanism, and inhibition of Hedgehog acyltransferase

Authors: Claire E Coupland, Sebastian A Andrei, T Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A Schwab, Eamon F X Byrne, Els Pardon, Jan Steyaert, Anthony I Magee, Thomas Lanyon-Hogg, Mark S P Sansom, Edward W Tate, Christian Siebold

Journal: Mol Cell

PubMed ID: 34890564

Doi: 10.1016/j.molcel.2021.11.018

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Analysis of CcGASA family members in Citrus clementina (Hort ex Tan) by a genome-wide approach

Authors: Tianli Wu, Yun Zhong, Min Chen, Bo Wu, Ting Wang, Bo Jiang, Guangyan Zhong

Journal: BMC Plant Biol

PubMed ID: 34852791

Doi: 10.1186/s12870-021-03326-6

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Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions

Authors: Charline Mary, Aurélien Fouillen, Pierre Moffatt, Dainelys Guadarrama Bello, Rima M Wazen, Daniel Grenier, Antonio Nanci

Journal: Sci Rep

PubMed ID: 34887426

Doi: 10.1038/s41598-021-02661-w

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The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity

Authors: Kari H Ecklund, Megan E Bailey, Kelly A Kossen, Carsten K Dietvorst, Charles L Asbury, Steven M Markus

Journal: J Cell Sci

PubMed ID: 34854468

Doi: 10.1242/jcs.258510

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KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Authors: John Fadul, Teresa Zulueta-Coarasa, Gloria M Slattum, Nadja M Redd, Mauricio Franco Jin, Michael J Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt

Journal: Nat Commun

PubMed ID: 34893591

Doi: 10.1038/s41467-021-27513-z

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RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors

Authors: Alexander Kuzin, Brendan Redler, Jaya Onuska, Alexei Slesarev

Journal: Sci Rep

PubMed ID: 34880355

Doi: 10.1038/s41598-021-03160-8

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Structural insights into Ubr1-mediated N-degron polyubiquitination

Authors: Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu, Minglei Zhao

Journal: Nature.

PubMed ID: 34789879

Doi: 10.1038/s41586-021-04097-8

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EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Mol Cancer

PubMed ID: 34856977

Doi: 10.1186/s12943-021-01456-x

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Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway

Authors: Baorong Jiang, Gehui Yuan, Jialin Wu, Qian Wu, Lei Li, Ping Jiang

Journal: Biochim Biophys Acta Mol Basis Dis

Doi: 10.1016/j.bbadis.2021.166320

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Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes

Authors: Ziyi Guo, Xunjin Zeng, Yu Zheng

Journal: Bioengineered

PubMed ID: 34787067

Doi: 10.1080/21655979.2021.2005895

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Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ axis

Authors: Xiaohui Lu, Haijie Gao, Bo Zhu, Guilan Lin

Journal: Bioengineered

PubMed ID: 34546853

Doi: 10.1080/21655979.2021.1964157

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The Retropepsin-Type Protease APRc as a Novel Ig-Binding Protein and Moonlighting Immune Evasion Factor of

Authors: Pedro Curto, Andreia Barro, Carla Almeida, Ricardo S Vieira-Pires, Isaura Simões

Journal: MBio

PubMed ID: 34872352

Doi: 10.1128/mBio.03059-21

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The WalR-WalK signaling pathway modulates the activities of both CwlO and LytE through control of the peptidoglycan deacetylase PdaC in

Authors: Genevieve S Dobihal, Josué Flores-Kim, Ian J Roney, Xindan Wang, David Z Rudner

Journal: J Bacteriol

PubMed ID: 34871030

Doi: 10.1128/JB.00533-21

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Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci

Authors: Hongming Dong, Yaolei Zhang, Jiahao Wang, Haitao Xiang, Tianhang Lv, Likun Wei, Shaosen Yang, Xiaopan Liu, Bingzhao Ren, Xiuqing Zhang, Lirong Liu, Jun Cao, Meiniang Wang, Jiahai Shi, Naibo Yang

Journal: J Immunol

PubMed ID: 34880108

Doi: 10.4049/jimmunol.2100844

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Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins

Authors: Fatemeh Haghayegh, Razieh Salahandish, Azam Zare, Mahmood Khalghollah, Amir Sanati-Nezhad

Journal: Lab Chip

PubMed ID: 34860233

Doi: 10.1039/d1lc00879j

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Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis

Authors: Zachary G Beamer, Pratyush Routray, Won-Gyu Choi, Margaret K Spangler, Ansul Lokdarshi, Daniel M Roberts

Journal: Plant Physiol

PubMed ID: 34890456

Doi: 10.1093/plphys/kiab196

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Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

Authors: Nadia E Aikawa, Leonard V K Kupa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Emily F N Yuki, Carla G S Saad, Tatiana Pedrosa, Ricardo Fuller, Samuel K Shinjo, Percival D Sampaio-Barros, Danieli C O Andrade, Rosa M R Pereira, Luciana P C Seguro, Juliana M L Valim, Filipe Waridel, Ana Marli C Sartori, Alberto J S Duarte, Leila Antonangelo, Ester C Sabino, Paulo Rossi Menezes, Esper G Kallas, Clovis A Silva, Eloisa Bonfa

Journal: Lancet Rheumatol

PubMed ID: 34901885

Doi: 10.1016/S2665-9913(21)00327-1

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Cleavage-Free Human Genome Editing

Authors: Chenzhong Kuang, Yan Xiao, Dirk Hondmann

Journal: Mol Ther

PubMed ID: 34864205

Doi: 10.1016/j.ymthe.2021.12.001

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Aquaporin expression and cholesterol content in eel swimbladder tissue

Authors: Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P Cutler, Bernd Pelster

Journal: J Fish Biol

PubMed ID: 34882794

Doi: 10.1111/jfb.14973

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Novel Variations in the Gene Causing X-Linked Intellectual Disability

Authors: Po-Ming Wu, Wen-Hao Yu, Chi-Wu Chiang, Chen-Yu Wu, Jia-Shing Chen, Yi-Fang Tu

Journal: Neurol Genet

PubMed ID: 34877407

Doi: 10.1212/NXG.0000000000000646

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FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Authors: Wenlu Fan, Xiaoye Jin, Man Xu, Yongmei Xi, Weiguo Lu, Xiaohang Yang, Min-Xin Guan, Wanzhong Ge

Journal: Nucleic Acids Res

PubMed ID: 34878141

Doi: 10.1093/nar/gkab1187

Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Authors: Brandon M Lane, Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C Middleton, Kinsie Huggins, Amika Sood, Alejandro Ochoa, Andrew F Malone, Ricardo Vancini, Sara E Miller, Gentzon Hall, So Young Kim, David N Howell, Jameela A Kari, Rasheed Gbadegesin

Journal: JCI Insight

PubMed ID: 34874915

Doi: 10.1172/jci.insight.152102

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The large nonstructural protein (NS1) of the human bocavirus 1 (HBoV1) directly interacts with Ku70, which plays an important role in virus replication in human airway epithelia

Authors: Liting Shao, Kang Ning, Jianke Wang, Fang Cheng, Shengqi Wang, Jianming Qiu

Journal: J Virol

PubMed ID: 34878919

Doi: 10.1128/JVI.01840-21

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Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins

Authors: Jieping Deng , Junping Pan, Minghui Qiu, Lipeng Mao , Zhigang Wang , Guodong Zhu , Lijuan Gao , Jun Su , Yutian Hu , Oscar Junhong Luo , Guobing Chen , Pengcheng Wang

Journal: J Leukoc Biol

PubMed ID: 34231935

Doi: 10.1002/JLB.4MA0621-020R

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