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OmpA may be used as a novel target to enrich and detect Escherichia coli in milk samples

Authors: Yichen Tian, Kaiqing Yang, Yaoqiang Shi, Jinyang Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song

Journal: J Dairy Sci

PubMed ID: 35151480

Doi: 10.3168/jds.2021-20974

Products & Services: Catalog Antibodies

Cytolysin A-mediated protein exportation efficiency and its role in enhancing the fitness of live recombinant Salmonella Typhi vaccine strain

Authors: F-K Loh, S Nathan, S-C Chow, C-M Fang

Journal: Lett Appl Microbiol

PubMed ID: 35138654

Doi: 10.1111/lam.13669

Products & Services: Gene Synthesis

Inhibition of the Interaction of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival in Hepatic Ischemia/Reperfusion

Authors: Timothy Borjas, Asha Jacob, HaoTing Yen, Vihas Patel, Gene F Coppa, Monowar Aziz, Ping Wang

Journal: Shock

PubMed ID: 34864782

Doi: 10.1097/SHK.0000000000001894

Products & Services: Peptide Synthesis

Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening

Authors: Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C E Tosatto

Journal: Cancers (Basel)

PubMed ID: 35205757

Doi: 10.3390/cancers14041009

Products & Services: Plasmid DNA Preparation

Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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Melanocortin receptor agonists suppress experimental autoimmune uveitis

Authors: Tat Fong Ng, Kaleb Dawit, Andrew W Taylor

Journal: Exp Eye Res

PubMed ID: 35196505

Doi: 10.1016/j.exer.2022.108986

Products & Services: Mammalian Expression

Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking

Authors: Constancio Gonzalez-Obeso, Fredrik G Backlund, David L Kaplan

Journal: Biomacromolecules

PubMed ID: 35113522

Doi: 10.1021/acs.biomac.1c01192

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SARS-CoV-2 neutralizing capacity among blood donors without prior COVID-19 symptomatic history vs blood donors with prior COVID-19 symptomatic history: A comparative study

Authors: Ushasree Ravula, Srinivasa Rao Chunchu, Srujaleswari Mooli, Ravi Naik, Pandu Ranga Rao Sarangapati

Journal: Transfus Clin Biol

PubMed ID: 35167958

Doi: 10.1016/j.tracli.2022.02.004

Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

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IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine

Authors: Lina G Mettler, Karin Brecht, Veronika Butterweck, Henriette E Meyer Zu Schwabedissen

Journal: Biomed Pharmacother

PubMed ID: 35149385

Doi: 10.1016/j.biopha.2022.112698

Products & Services: Protein Electrophoresis and Western

The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases

Authors: Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer, Alisa Markgraf, Philine Falk, Jakob Reich, Friedrich Riess, Philipp Girl, Katharina Müller, Katja Radon, Jessica Michelle Guggenbuehl Noller, Roman Wölfel, Michael Hoelscher, Inge Kroidl, Andreas Wieser, Laura Olbrich

Journal: Virology

PubMed ID: 35245784

Doi: 10.1016/j.virol.2022.02.002

Biochemical Screening of Potent Zika Virus Protease Inhibitors

Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele

Journal: ChemMedChem

PubMed ID: 35104396

Doi: 10.1002/cmdc.202100695

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Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression

Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin

Journal: Mol Med Rep

PubMed ID: 35169864

Doi: 10.3892/mmr.2022.12639

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Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression

Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin

Journal: Mol Med Rep

PubMed ID: 35169864

Doi: 10.3892/mmr.2022.12639

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Circular dichroism spectroscopic assessment of structural changes upon protein thermal unfolding at contrasting pH: Comparison with molecular dynamics simulations

Authors: Ponciano García-Gutiérrez, Menandro Camarillo-Cadena, Liliana I Vera-Robles, Rafael A Zubillaga, Andrés Hernández-Arana

Journal: Spectrochim Acta A Mol Biomol Spectrosc

PubMed ID: 35245803

Doi: 10.1016/j.saa.2022.121039

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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines

Authors: Noëmi Johanna Roos, Riccardo Vincenzo Mancuso, Gerda Mawududzi Sanvee, Jamal Bouitbir, Stephan Krähenbühl

Journal: Food Chem Toxicol

PubMed ID: 35182693

Doi: 10.1016/j.fct.2022.112869

Products & Services: Protein Electrophoresis and Western

Long noncoding RNASEH1-AS1 exacerbates the progression of non-small cell lung cancer by acting as a ceRNA to regulate microRNA-516a-5p/FOXK1 and thereby activating the Wnt/β-catenin signaling pathway

Authors: Chan Zhang, Jian Huang, Ke Lou, Hui Ouyang

Journal: Cancer Med

PubMed ID: 35166053

Doi: 10.1002/cam4.4509

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Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system

Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana

Journal: Parasitol Res

PubMed ID: 35169884

Doi: 10.1007/s00436-022-07466-y

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Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system

Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana

Journal: Parasitol Res

PubMed ID: 35169884

Doi: 10.1007/s00436-022-07466-y

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Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C

Authors: Juanjie Tang, Adrienne G Randolph, Tanya Novak, Tracie C Walker, Laura L Loftis, Matt S Zinter, Katherine Irby, Surender Khurana

Journal: Vaccines (Basel)

PubMed ID: 35214728

Doi: 10.3390/vaccines10020270

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Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ-Mediated Neurotoxicity

Authors: Xinyu Li, Yiyu Zhang, Hui-Wang Ai

Journal: ACS Sens

PubMed ID: 35226474

Doi: 10.1021/acssensors.1c01381

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Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy

Authors: Yashika Rustagi, Ahmed S Abouhashem, Priyanka Verma, Sumit S Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R Guda, Rajneesh Srivastava, Sujit K Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E Wanczyk, Savita Khanna, Michael P Murphy, Gayle M Gordillo, Sashwati Roy, Jun Wan, Chandan K Sen, Kanhaiya Singh

Journal: Diabetes

PubMed ID: 35192691

Doi: 10.2337/db21-0830

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Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1

Authors: Yu-Syuan Wei, Wan-Zhen Lin, Tse-En Wang, Wei-Yun Lee, Sheng-Hsiang Li, Fu-Jung Lin, Brett Nixon, Petra Sipilä, Pei-Shiue Tsai

Journal: J Reprod Dev

PubMed ID: 35228412

Doi: 10.1262/jrd.2021-128

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Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383

Authors: Chaorui Xu, Zhuowen Jia, Xuefei Cao, Sha Wang, Jipeng Wang, Liping An

Journal: Cell Cycle

PubMed ID: 35192424

Doi: 10.1080/15384101.2022.2040122

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Rapid colloidal gold immunochromatographic assay for the detection of SARS-CoV-2 total antibodies after vaccination

Authors: Liya Ye, Xinxin Xu, Shanshan Song, Liguang Xu, Hua Kuang, Chuanlai Xu

Journal: J Mater Chem B

PubMed ID: 35212337

Doi: 10.1039/d1tb02521j

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Adaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from CH4

Authors: Deepika Awasthi, Yung-Hsu Tang, Bashar Amer, Edward E K Baidoo, Jennifer Gin, Yan Chen, Christopher J Petzold, Marina Kalyuzhnaya, Steven W Singer

Journal: J Ind Microbiol Biotechnol

PubMed ID: 35134957

Doi: 10.1093/jimb/kuac002

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Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

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PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

Authors: Ruhul H Choudhury, Peter Symonds, Samantha J Paston, Ian Daniels, Katherine W Cook, Mohamed Gijon, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 35140112

Doi: 10.1136/jitc-2021-003526

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Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

Products & Services: Gene Synthesis

APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

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IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy

Authors: Pengsen Wu, Bingying Lin, Siyu Huang, Jie Meng, Fan Zhang, Min Zhou, Xiangqing Hei, Yu Ke, Huasheng Yang, Danping Huang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35273577

Doi: 10.3389/fendo.2022.846106

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Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D

Authors: Hongyan Long, Bart E Vos, Timo Betz, Brendon M Baker, Britta Trappmann

Journal: Adv Sci (Weinh)

PubMed ID: 35187856

Doi: 10.1002/advs.202105325

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The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin

Authors: Shengnan Zheng, Biyu Zheng, Zhenbang Liu, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Wenfan Wei, Chuanhai Fu

Journal: J Cell Sci

PubMed ID: 35048989

Doi: 10.1242/jcs.259228

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Fine mapping and cloning of the major seed protein quantitative trait loci on soybean chromosome 20

Authors: Christina E Fliege, Russell A Ward, Pamela Vogel, Hanh Nguyen, Truyen Quach, Ming Guo, João Paulo Gomes Viana, Lucas Borges Dos Santos, James E Specht, Tom E Clemente, Matthew E Hudson, Brian W Diers

Journal: Plant J

PubMed ID: 34978122

Doi: 10.1111/tpj.15658

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Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato

Authors: Anurag Kashyap, Álvaro Luis Jiménez-Jiménez, Weiqi Zhang, Montserrat Capellades, Sumithra Srinivasan, Anna Laromaine, Olga Serra, Mercè Figueras, Jorge Rencoret, Ana Gutiérrez, Marc Valls, Nuria S Coll

Journal: New Phytol

PubMed ID: 35152435

Doi: 10.1111/nph.17982

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CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

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Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Authors: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Journal: Sci Signal

PubMed ID: 35192416

Doi: 10.1126/scisignal.abj3

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Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Authors: Shenglong Zhu , Wei Wang , Jingwei Zhang , Siyu Ji , Zhe Jing , Yong Q Chen

Journal: Cell Mol Biol Lett

PubMed ID: 35109789

Doi: 10.1186/s11658-022-00314-y

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Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein

Authors: Oskar Staufer, Kapil Gupta, Jochen Estebano Hernandez Bücher, Fabian Kohler, Christian Sigl, Gunjita Singh, Kate Vasileiou, Ana Yagüe Relimpio, Meline Macher, Sebastian Fabritz, Hendrik Dietz, Elisabetta Ada Cavalcanti Adam, Christiane Schaffitzel, Alessia Ruggieri, Ilia Platzman, Imre Berger, Joachim P Spatz

Journal: Nat Commun

PubMed ID: 35165285

Doi: 10.1038/s41467-022-28446-x

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A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody Detection

Authors: Rui-Lin Huang, Yi-Chen Fu, Yung-Chih Wang, Chitsung Hong, Wei-Chieh Yang, I-Jen Wang, Jun-Ren Sun, Yunching Chen, Ching-Fen Shen, Chao-Min Cheng

Journal: Vaccines (Basel)

PubMed ID: 35214731

Doi: 10.3390/vaccines10020271

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Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Authors: Youwen Zhuang, Lei Wang, Jia Guo, Dapeng Sun, Yue Wang, Weiyi Liu, H Eric Xu, Cheng Zhang

Journal: Nat Commun

PubMed ID: 35217703

Doi: 10.1038/s41467-022-28586-0

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N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Authors: Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Journal: Biochem J

PubMed ID: 35023554

Doi: 10.1042/BCJ20210829

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Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly

Authors: Krishnendu Khan, Briana Long, Camelia Baleanu-Gogonea, Valentin Gogonea, Gauravi M Deshpande, Kommireddy Vasu, Paul L Fox

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35140182

Doi: 10.1073/pnas.2115799119

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Hot Hydrogen Atom Irradiation of Protonated/Deprotonated Peptide in an Ion Trap Facilitates Fragmentation through Heated Radical Formation

Authors: Daiki Asakawa, Hidenori Takahashi, Shinichi Iwamoto, Koichi Tanaka

Journal: J Am Chem Soc

PubMed ID: 35138819

Doi: 10.1021/jacs.1c11081

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Molecular Characterization and Gene Expression Analysis of Aquaporin in

Authors: Qingli Niu, Rongzeng Hao, Yuping Pan, Zhijie Liu, Jifei Yang, Guiquan Guan, Jianxun Luo, Hong Yin

Journal: Front Physiol

PubMed ID: 35250616

Doi: 10.3389/fphys.2022.811628

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Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-b1Induced OCT4/Nanog Pathway

Authors: Wenting Li, Xiaoqiong Duan, Chuanlong Zhu, Xiao Liu, Andre J Jeyarajan, Min Xu, Zeng Tu, Qiuju Sheng, Dong Chen, Chuanwu Zhu, Tuo Shao, Zhimeng Cheng, Shadi Salloum, Esperance A Schaefer, Annie J Kruger, Jacinta A Holmes, Raymond T Chung, Wenyu Lin

Journal: J Immunol

PubMed ID: 35022275

Doi: doi/10.4049/jimmunol.2001453

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Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Authors: Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35193873

Doi: 10.1136/annrheumdis-2021-221916

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Evolution and conserved functionality of organ size and shape regulator PEAPOD

Authors: Ruth Cookson, Somrutai Winichayakul, Hong Xue, Kim Richardson, Roger Moraga, Aurelie Laugraud, Ambarish Biswas, Greg Bryan, Nick Roberts

Journal: PLoS ONE

PubMed ID: 35148336

Doi: 10.1371/journal.pone.0263928

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Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination Strategies

Authors: Matthaios Speletas, Ioanna Voulgaridi, Styliani Sarrou, Aikaterini Dadouli, Varvara A Mouchtouri, Dimitrios J Nikoulis, Maria Tsakona, Maria A Kyritsi, Athanasia-Marina Peristeri, Ioanna Avakian, Asimina Nasika, Paraskevi C Fragkou, Charalampos D Moschopoulos, Stamatia Zoubouneli, Ilias Onoufriadis, Lemonia Anagnostopoulos, Alexia Matziri, Georgia Papadamou, Aikaterini Theodoridou, Sotirios Tsiodras, Christos Hadjichristodoulou

Journal: Vaccines (Basel)

PubMed ID: 35214774

Doi: 10.3390/vaccines10020316

Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis

Authors: Kevin Yau, Christopher T Chan, Kento T Abe, Yidi Jiang, Mohammad Atiquzzaman, Sarah I Mullin, Ellen Shadowitz, Lisa Liu, Ema Kostadinovic, Tatjana Sukovic, Anny Gonzalez, Margaret E McGrath-Chong, Matthew J Oliver, Jeffrey Perl, Jerome A Leis, Shelly Bolotin, Vanessa Tran, Adeera Levin, Peter G Blake, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: CMAJ

PubMed ID: 35115375

Doi: 10.1503/cmaj.211881

Products & Services: Mammalian Expression

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs

Authors: Margarida Saramago, Vanessa G Costa, Caio S Souza, Cátia Bárria, Susana Domingues, Sandra C Viegas, Diana Lousa, Cláudio M Soares, Cecília M Arraiano, Rute G Matos

Journal: Microorganisms

PubMed ID: 35208797

Doi: 10.3390/microorganisms10020342

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The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Authors: Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina

Journal: Nat Commun

PubMed ID: 35115561

Doi: 10.1038/s41467-022-28360-2

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Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Authors: Siew C Ng, Ye Peng, Lin Zhang, Chris Kp Mok, Shilin Zhao, Amy Li, Jessica Yl Ching, Yingzhi Liu, Shuai Yan, Dream L S Chan, Jie Zhu, Chunke Chen, Adrian Ch Fung, Kenneth Ky Wong, David Sc Hui, Francis Kl Chan, Hein M Tun

Journal: Gut

PubMed ID: 35140064

Doi: 10.1136/gutjnl-2021-326563

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Inhibition of base editors with anti-deaminases derived from viruses

Authors: Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li

Journal: Nat Commun

PubMed ID: 35105899

Doi: 10.1038/s41467-022-28300-0

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Sensitivity of eight types of ALK fusion variant to alectinib in ALK-transformed cells

Authors: Koh Furugaki, Naoki Harada, Yasushi Yoshimura

Journal: Anticancer Drugs

PubMed ID: 34520436

Doi: 10.1097/CAD.0000000000001249

Products & Services: Mammalian Expression

Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination

Authors: Christina Strauch, Thu-Huong Hoang, Frank Angenstein, Denise Manahan-Vaughan

Journal: Cereb Cortex

PubMed ID: 34379749

Doi: 10.1093/cercor/bhab226

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Chloroplast translational regulation uncovers nonessential photosynthesis genes as key players in plant cold acclimation

Authors: Yang Gao, Wolfram Thiele, Omar Saleh, Federico Scossa, Fayezeh Arabi, Hongmou Zhang, Arun Sampathkumar, Kristina Kühn, Alisdair Fernie, Ralph Bock, Mark A Schöttler, Reimo Zoschke

Journal: Plant Cell

PubMed ID: 35171295

Doi: 10.1093/plcell/koac056

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Vaccine Candidate Double Mutant Variants of Enterotoxigenic Heat-Stable Toxin

Authors: Ephrem Debebe Zegeye, Yuleima Diaz, Pål Puntervoll

Journal: Vaccines (Basel)

PubMed ID: 35214698

Doi: 10.3390/vaccines10020241

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Performance evaluation of four surrogate Virus Neutralization Tests (sVNTs) in comparison to the gold standard test

Authors: Massimo Pieri, Maria Infantino, Mariangela Manfredi, Marzia Nuccetelli, Valentina Grossi, Barbara Lari, Flaminia Tomassetti, Serena Sarubbi, Edda Russo, Amedeo Amedei, Maurizio Benucci, Patrizia Casprini, Lorenzo Stacchini, Concetta Castilletti, Sergio Bernardini

Journal: Front Biosci (Landmark Ed)

PubMed ID: 35227017

Doi: 10.31083/j.fbl2702074

Structural characterization of a new subclass of panicum mosaic virus-like 3' cap-independent translation enhancer

Authors: Philip Z Johnson, Wojciech K Kasprzak, Bruce A Shapiro, Anne E Simon

Journal: Nucleic Acids Res

PubMed ID: 35104872

Doi: 10.1093/nar/gkac007

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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Authors: Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder

Journal: Nat Commun

PubMed ID: 35149678

Doi: 10.1038/s41467-022-28396-4

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Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort

Authors: Hoa Thi My Vo, Alvino Maestri, Heidi Auerswald, Sopheak Sorn, Sokchea Lay, Heng Seng, Sotheary Sann, Nisa Ya, Polidy Pean, Philippe Dussart, Olivier Schwartz, Sovann Ly, Timothée Bruel, Sowath Ly, Veasna Duong, Erik A Karlsson, Tineke Cantaert

Journal: Front Immunol

PubMed ID: 35185909

Doi: 10.3389/fimmu.2022.817905

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Defining molecular glues with a dual-nanobody cannabidiol sensor

Authors: Shiyun Cao, Shoukai Kang, Haibin Mao, Jiayu Yao, Liangcai Gu, Ning Zheng

Journal: Nat Commun

PubMed ID: 35145136

Doi: 10.1038/s41467-022-28507-1

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Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

Authors: Fin J Milder, Mandy Jongeneelen, Tina Ritschel, Pascale Bouchier, Ilona J M Bisschop, Martijn de Man, Daniel Veldman, Lam Le, Baerbel Kaufmann, Mark J G Bakkers, Jarek Juraszek, Boerries Brandenburg, Johannes P M Langedijk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35131851

Doi: 10.1073/pnas.2115379119

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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Authors: Daichao Wu, Ragul Gowathaman, Brian G Pierce, Roy A Mariuzza

Journal: J Biol Chem

PubMed ID: 35124005

Doi: 10.1016/j.jbc.2022.101684

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Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism

Authors: Elif Eren, Bing Wang, Dennis C Winkler, Norman R Watts, Alasdair C Steven, Paul T Wingfield

Journal: Structure

PubMed ID: 35150605

Doi: 10.1016/j.str.2022.01.008

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Optical Sensors and Actuators for Probing Proximity-Dependent Biotinylation in Living Cells

Authors: Rui Chen, Ningxia Zhang, Yubin Zhou, Ji Jing

Journal: Front Cell Neurosci

PubMed ID: 35250484

Doi: 10.3389/fncel.2022.801644

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Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses

Authors: Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Jarvis Hill, Naomi E Kramer, Jackelyn Murray, Brady M O'Boyle, Emmanuel Onobun, Michael G Pirrone, Justin D Shepard, Suzanne Enos, Yagya P Subedi, Kapil Upadhyaya, Ralph A Tripp, Brian S Cummings, David Crich, Scott D Pegan

Journal: ACS Infect Dis

PubMed ID: 35199517

Doi: 10.1021/acsinfecdis.1c00631

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Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase

Authors: Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F AlAsmari, Mohd A Rauf, Krishna K Inampudi, Deepak Sehgal

Journal: Molecules

PubMed ID: 35268608

Doi: 10.3390/molecules27051505

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DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse

Authors: Kelsey S Moore, Reece Moore, Diana B Fulmer, Lilong Guo, Cortney Gensemer, Rebecca Stairley, Janiece Glover, Tyler C Beck, Jordan E Morningstar, Rachel Biggs, Rupak Muhkerjee, Alexander Awgulewitsch, Russell A Norris

Journal: J Cardiovasc Dev Dis

PubMed ID: 35200715

Doi: 10.3390/jcdd9020062

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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies

Authors: Garima Kumar, Sarah Sterrett, Lucinda Hall, Edlue Tabengwa, Kazuhito Honjo, Michael Larimer, Randall S Davis, Paul A Goepfert, Benjamin M Larimer

Journal: Protein Eng Des Sel

PubMed ID: 35174857

Doi: 10.1093/protein/gzab033

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Systematic profiling of antigen bias in humoral response against SARS-CoV-2

Authors: Nana Wei, Qiujing Wang, Zhibing Lin, Liyun Xu, Zheen Zhang, Yan Wang, Zhejuan Yang, Lue Li, Tingxiao Zhao, Lu Wang, Haifei Lou, Mingfang Han, Mingliang Ma, Yaosheng Jiang, Jinmiao Lu, Shilan Zhu, Li Cui, Shibo Li

Journal: Virus Res

PubMed ID: 35176329

Doi: 10.1016/j.virusres.2022.198711

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Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

Authors: Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi, Mostafa T Mohammed, Brigid Bohan, Vikram Pattanayak, Ivy Rosales, Paolo Cravedi, Camille N Kotton, Jamil R Azzi, Leonardo V Riella

Journal: Front Immunol

PubMed ID: 35281011

Doi: 10.3389/fimmu.2022.838985

miR-145-5p inhibits the proliferation of glioma stem cells by targeting translationally controlled tumor protein

Authors: Qiujian Zhang, Zhe Cheng, Lei Shi, Gengsheng Mao

Journal: J Cancer

PubMed ID: 35371310

Doi: 10.7150/jca.65543

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Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene

Authors: Yue Zhao, Zhengzheng Cao, Luqing Cui, Tianyu Hu, Kaixuan Guo, Fan Zhang, Xiangru Wang, Zhong Peng, Quan Liu, Menghong Dai

Journal: Front Microbiol

PubMed ID: 35250901

Doi: 10.3389/fmicb.2021.773664

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In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

Authors: Fang-Yi Su, Qingyang Henry Zhao, Shreyas N Dahotre, Lena Gamboa, Swapnil Subhash Bawage, Aaron D Silva Trenkle, Ali Zamat, Hathaichanok Phuengkham, Rafi Ahmed, Philip J Santangelo, Gabriel A Kwong

Journal: Sci Adv

PubMed ID: 35196075

Doi: 10.1126/sciadv.abm7950

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Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias

Authors: Giuditta Dal Cortivo , Carlo Giorgio Barracchia , Valerio Marino , Mariapina D'Onofrio , Daniele Dell'Orco

Journal: Cell Mol Life Sci

PubMed ID: 35133504

Doi: 10.1007/s00018-022-04165-w

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The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane

Authors: Melissa S Traver , Sarah E Bradford , Jose Luis Olmos Jr , Zachary J Wright , Mitchell D Miller , Weijun Xu , George N Phillips Jr , Bonnie Bartel

Journal: Front Cell Dev Biol

PubMed ID: 35300425

Doi: 10.3389/fcell.2022.838923

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A continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity

Authors: Thomas Asensio , Cyril Dian , Jean-Baptiste Boyer , Frédéric Rivière, Thierry Meinnel , Carmela Giglione

Journal: Front Plant Sci

PubMed ID: 35273627

Doi: 10.3389/fpls.2022.832144

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Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor in Lamb

Authors: Peizhen Chen, Rong Li, Lingzhi Zhu, Qingqing Hao, Sheng Yao, Jiahe Liu, Kongshu Ji

Journal: Int J Mol Sci

PubMed ID: 35216196

Doi: 10.3390/ijms23042079

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Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Authors: Gregor L Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165386

Doi: 10.1038/s41564-021-01055-y

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Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)

Authors: Guanying Wang, Zhongping Xu, Fuqiu Wang, Yuefan Huang, Yanfeng Xin, Sijia Liang, Bo Li, Huan Si, Lin Sun, Qiongqiong Wang, Xiao Ding, Xiangqian Zhu, Luo Chen, Lu Yu, Keith Lindsey, Xianlong Zhang, Shuangxia Jin

Journal: BMC Biol

PubMed ID: 35164736

Doi: 10.1186/s12915-022-01232-3

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WIN site inhibition disrupts a subset of WDR5 function

Authors: Andrew J Siladi, Jing Wang, Andrea C Florian, Lance R Thomas, Joy H Creighton, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Gregory C Howard, Stephen W Fesik, April M Weissmiller, Qi Liu, William P Tansey

Journal: Sci Rep

PubMed ID: 35115608

Doi: 10.1038/s41598-022-05947-9

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TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A

Authors: X Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M Rodriguez, Caiwei Guo, Tetsuya Akiyama, H Broder Schmidt, Beryl B Cummings, David W Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D Rubien, Karen Jansen-West, Casey N Cook, Sarah Pickles, Björn Oskarsson, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Dennis W Dickson, James Shorter, Sua Myong, Eric M Green, William W Seeley, Leonard Petrucelli, Aaron D Gitler

Journal: Nature

PubMed ID: 35197626

Doi: 10.1038/s41586-022-04424-7

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An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library

Authors: Shuhua G Li, Kai S Yang, Lauren R Blankenship, Chia-Chuan D Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu

Journal: Front Chem

PubMed ID: 35252116

Doi: 10.3389/fchem.2022.816576

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A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

Authors: Sarah F Andrews, Julie E Raab, Jason Gorman, Rebecca A Gillespie, Crystal S F Cheung, Reda Rawi, Lauren Y Cominsky, Jeffrey C Boyington, Adrian Creanga, Chen-Hsiang Shen, Darcy R Harris, Adam S Olia, Alexandra F Nazzari, Tongqing Zhou, Katherine V Houser, Grace L Chen, John R Mascola, Barney S Graham, Masaru Kanekiyo, Julie E Ledgerwood, Peter D Kwong, Adrian B McDermott

Journal: Nat Med

PubMed ID: 35115707

Doi: 10.1038/s41591-021-01636-8

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Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

Authors: Jacqueto Zephyr, Desaboini Nageswara Rao, Sang V Vo, Mina Henes, Klajdi Kosovrasti, Ashley N Matthew, Adam K Hedger, Jennifer Timm, Elise T Chan, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer

Journal: J Mol Biol

PubMed ID: 35183560

Doi: 10.1016/j.jmb.2022.167503

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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration

Authors: Elena I Ilina, Camille Cialini, Dietlind L Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P Niclou, Tanja Müller, Michel Mittelbronn

Journal: iScience

PubMed ID: 35198895

Doi: 10.1016/j.isci.2022.103842

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Molecular basis of receptor binding and antibody neutralization of Omicron

Authors: Qin Hong, Wenyu Han, Jiawei Li, Shiqi Xu, Yifan Wang, Cong Xu, Zuyang Li, Yanxing Wang, Chao Zhang, Zhong Huang, Yao Cong

Journal: Nature

PubMed ID: 35228716

Doi: 10.1038/s41586-022-04581-9

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DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice

Authors: Jinni Chen, Yao Deng, Baoying Huang, Di Han, Wen Wang, Mengjing Huang, Chengcheng Zhai, Zhimin Zhao, Ren Yang, Ying Zhao, Wenling Wang, Desheng Zhai, Wenjie Tan

Journal: Front Immunol

PubMed ID: 35281016

Doi: 10.3389/fimmu.2022.827605

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Human Milk SARS-CoV-2 Antibodies up to 6 Months After Vaccination

Authors: Stephanie E Perez, Luis Diego Luna Centeno, Wesley A Cheng, Carolyn Jennifer Marentes Ruiz, Yesun Lee, Zion Congrave-Wilson, Rebecca L Powell, Lisa Stellwagen, Pia S Pannaraj

Journal: Pediatrics

PubMed ID: 34981122

Doi: 10.1542/peds.2021-054260

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Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E coli

Authors: Parthasarathy Manikandan, Sankaran Sandhya, Kavyashree Nadig, Souradip Paul, Narayanaswamy Srinivasan, Ulli Rothweiler, Mahavir Singh

Journal: Nucleic Acids Res

PubMed ID: 35018473

Doi: 10.1093/nar/gkab1264

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Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population

Authors: Sonja Kopanja, Pia Gattinger, Klara Schmidthaler, Justyna Sieber, Katarzyna Niepodziana, Thomas Schlederer, Lukas Weseslindtner, Karin Stiasny, Florian Götzinger, Winfried F Pickl, Thomas Frischer, Rudolf Valenta, Zsolt Szépfalusi

Journal: Pediatr Allergy Immunol

PubMed ID: 35212039

Doi: 10.1111/pai.13737

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From musk to body odor: Decoding olfaction through genetic variation

Authors: Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang

Journal: PLoS Genet

PubMed ID: 35113854

Doi: 10.1371/journal.pgen.1009564

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Detection of SARS-CoV-2 Omicron variant (B11529) infection of white-tailed deer

Authors: Kurt J Vandegrift, Michele Yon, Meera Surendran-Nair, Abhinay Gontu, Saranya Amirthalingam, Ruth H Nissly, Nicole Levine, Tod Stuber, Anthony J DeNicola, Jason R Boulanger, Nathan Kotschwar, Sarah Grimké Aucoin, Richard Simon, Katrina Toal, Randall J Olsen, James J Davis, Dashzeveg Bold, Natasha N Gaudreault, Juergen A Richt, James M Musser, Peter J Hudson, Vivek Kapur, Suresh V Kuchipudi

Journal: biorxiv

PubMed ID: 35169802

Doi: 10.1101/2022.02.04.479189

Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

Authors: Mark Stoneley, Robert F Harvey, Thomas E Mulroney, Ryan Mordue, Rebekah Jukes-Jones, Kelvin Cain, Kathryn S Lilley, Ritwick Sawarkar, Anne E Willis

Journal: Mol Cell

PubMed ID: 35180429

Doi: 10.1016/j.molcel.2022.01.019

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Selective Detection of Serogroup 1 and 5 with a Digital Photocorrosion Biosensor Using Antimicrobial Peptide-Antibody Sandwich Strategy

Authors: M Amirul Islam, Walid M Hassen, Ishika Ishika, Azam F Tayabali, Jan J Dubowski

Journal: Biosensors (Basel)

PubMed ID: 35200365

Doi: 10.3390/bios12020105

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A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protects Pigs against PCV2b Challenge and Induces Serum Neutralizing Antibody Response against CSFV

Authors: Selvaraj Pavulraj, Katrin Pannhorst, Rhett W Stout, Daniel B Paulsen, Mariano Carossino, Denise Meyer, Paul Becher, Shafiqul I Chowdhury

Journal: Vaccines (Basel)

PubMed ID: 35214763

Doi: 10.3390/vaccines10020305

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