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Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy

Authors: Songfa Zhang, Chuan Yan, David G Millar, Qiqi Yang, James M Heather, Adam Langenbucher, Laura T Morton, Sean Sepulveda, Eric Alpert, Lauren R Whelton, Dominique T Zarrella, Mei Guo, Eleanor Minogue, Michael S Lawrence, Bo R Rueda, David R Spriggs, Weiguo Lu, David M Langenau, Mark Cobbold

Journal: Cancer Res

PubMed ID: 34965933

Doi: 10.1158/0008-5472.CAN-21-2200

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The N-terminal helices of amphiphysin and endophilin have different capabilities of membrane remodeling

Authors: Chinta M Aryal, Nhat Nguyen Bui, Likai Song, Jianjun Pan

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35247332

Doi: 10.1016/j.bbamem.2022.183907

Products & Services: Stable Cell Lines

SARS-CoV-2's high rate of genetic mutation under immune selective pressure: from oropharyngeal B117 to intrapulmonary B1533 in a post-vaccine patient

Authors: Nicolò Musso, Jessica Giuseppina Maugeri, Dafne Bongiorno, Stefano Stracquadanio, Giovanni Bartoloni, Stefania Stefani, Emanuela Daniela Di Stefano

Journal: Int J Infect Dis

PubMed ID: 35247550

Doi: 10.1016/j.ijid.2022.02.044

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Enantioselectivity and key residue of Herbaspirillum huttiense monooxygenase in asymmetric epoxidation of styrenes

Authors: Shuang Dong, Donglin Fan, Qian Liu, Yinyin Meng, Xinyu Liu, Sen Yang, Hui Lin, Na Li, Hongge Chen

Journal: Appl Microbiol Biotechnol

PubMed ID: 35230494

Doi: 10.1007/s00253-022-11843-z

Products & Services: Protein Electrophoresis and Western

Mxi1-0 Promotes Hypoxic Pulmonary Hypertension ERK/c-Myc-dependent Proliferation of Arterial Smooth Muscle Cells

Authors: Liang Dong, Xinning Liu, Bo Wu, Chengwei Li, Xiaomin Wei, Gulinuer Wumaier, Xiujuan Zhang, Jing Wang, Jingwen Xia, Yuanyuan Zhang, Ruzetuoheti Yiminniyaze, Ning Zhu, Jing Li, Daibing Zhou, Youzhi Zhang, Shuanghui Li, Junzhu Lv, Shengqing Li

Journal: Front Genet

PubMed ID: 35401684

Doi: 10.3389/fgene.2022.810157

Products & Services: Recombinant Antibody Expression

New insights into the resistance mechanism for the BceAB-type transporter SaNsrFP

Authors: Julia Gottstein, Julia Zaschke-Kriesche, Sandra Unsleber, Irina Voitsekhovskaia, Andreas Kulik, Lara V Behrmann, Nina Overbeck, Kai Stühler, Evi Stegmann, Sander H J Smits

Journal: Sci Rep

PubMed ID: 35273305

Doi: 10.1038/s41598-022-08095-2

Products & Services: Protein and Antibody Isolation

Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX-a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine

Authors: Samantha M Y Chen, Yik Chun Wong, Lok Yan Yim, Haoji Zhang, Hui Wang, Grace Chung Yan Lui, Xin Li, Xian Tang, Lin Cheng, Yanhua Du, Qiaoli Peng, Jinlin Wang, Hau-Yee Kwok, Haode Huang, Thomas Tsz-Kan Lau, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Li Liu, Lisa A Chakrabarti, Shui Shan Lee, Zhiwei Chen

Journal: J Virol

PubMed ID: 35297660

Doi: 10.1128/jvi.02161-21

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Novel Secreted Peptides From var With Immunomodulatory Effects That Enhance Fungal Pathogenesis

Authors: Sameh S M Soliman, Eman M El-Labbad, Ameera Abu-Qiyas, Bahgat Fayed, Alshaimaa M Hamoda, Ahmed M Al-Rawi, Salam Dakalbab, Abdel-Nasser A El-Shorbagi, Mawieh Hamad, Ashraf S Ibrahim, Mohammad G Mohammad

Journal: Front Microbiol

PubMed ID: 35387075

Doi: 10.3389/fmicb.2022.863133

Products & Services: Peptide Synthesis

Chromatin remodeling factors OsYAF9 and OsSWC4 interact to promote internode elongation in rice

Authors: Aziz Ul Ikram, Fei Zhang, Zuntao Xu, Enze Li, Gan Xue, Shiliang Wang, Cheng Zhang, Yachun Yang, Yanhua Su, Yong Ding

Journal: Plant Physiol

PubMed ID: 35157083

Doi: 10.1093/plphys/kiac031

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Identification and Validation of Autophagy-Related Genes in Vitiligo

Authors: Yiwen Yang, Xiuyi Wu, Xiaoli Lu, Chen Wang, Leihong Xiang, Chengfeng Zhang

Journal: Cells

PubMed ID: 35406685

Doi: 10.3390/cells11071116

Products & Services: Protein and Antibody Isolation

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

Authors: Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H Apponi, Pachamuthu Kandasamy, Chandra Vargeese

Journal: Nat Biotechnol

PubMed ID: 35256816

Doi: 10.1038/s41587-022-01225-1

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Symmetric and asymmetric receptor conformation continuum induced by a new insulin

Authors: Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G Menting, Ingmar B Schäfer, Heidi L Schubert, Rahul Agrawal, Theresia Gutmann, Carlie Delaine, Yi Wolf Zhang, Gizem Olay Artik, Allanah Merriman, Debbie Eckert, Michael C Lawrence, Ünal Coskun, Simon J Fisher, Briony E Forbes, Helena Safavi-Hemami, Christopher P Hill, Danny Hung-Chieh Chou

Journal: Nat Chem Biol

PubMed ID: 35289328

Doi: 10.1038/s41589-022-00981-0

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Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals

Authors: Nicolás A Muena, Tamara García-Salum, Catalina Pardo-Roa, María José Avendaño, Eileen F Serrano, Jorge Levican, Leonardo I Almonacid, Gonzalo Valenzuela, Estefany Poblete, Shirin Strohmeier, Erick Salinas, Andres Muñoz, Denise Haslwanter, Maria Eugenia Dieterle, Rohit K Jangra, Kartik Chandran, Claudia González, Arnoldo Riquelme, Florian Krammer, Nicole D Tischler, Rafael A Medina

Journal: EBioMedicine

PubMed ID: 35366624

Doi: 10.1016/j.ebiom.2022.103972

Products & Services: Protein and Antibody Isolation

A Faster, Novel Technique to Detect COVID-19 Neutralizing Antibodies

Authors: Wei-Huai Chiu, Wei-Yi Kong, Yu-Jang Su, Jyun-Wei Wen, Ciao-Ming Tsai, Chitsung Hong, Pang-Yen Chen, Cheng-Hao Ko

Journal: Med Sci Monit

PubMed ID: 35340017

Doi: 10.12659/MSM.935812

Design and Characterization of Novel Antibody-Cytokine Fusion Proteins Based on Interleukin-21

Authors: Cesare Di Nitto, Dario Neri, Tobias Weiss, Michael Weller, Roberto De Luca

Journal: Antibodies (Basel)

PubMed ID: 35323193

Doi: 10.3390/antib11010019

Products & Services: Protein Electrophoresis and Western

Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate

Authors: Ian Seim, Ammon E Posey, Wilton T Snead, Benjamin M Stormo, Daphne Klotsa, Rohit V Pappu, Amy S Gladfelter

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35333653

Doi: 10.1073/pnas.2120799119

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Anti-SARS-CoV-2 Neutralizing Antibody Responses after Two Doses of ChAdOx1 nCoV-19 vaccine (AZD1222) in Healthcare Workers

Authors: Sera Lim, Yuil Lee, Dong Wan Kim, Won Sang Park, Jung Hwan Yoon, Jung Young Lee

Journal: Infect Chemother

PubMed ID: 35384425

Doi: 10.3947/ic.2022.0009

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Determination of T Cell Responses in Thai Systemic Sclerosis Patients

Authors: Oranit Likhit, Worawit Louthrenoo, Sa-Nga Pattanakitsakul, Aroonroong Suttitheptumrong, Supot Hannongbua, Thanyada Rungrotmongkol, Hiroshi Noguchi, Fujio Takeuchi, Kobporn Boonnak

Journal: J Immunol Res

PubMed ID: 35310606

Doi: 10.1155/2022/5072154

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Multimodal evaluation of an interphotoreceptor retinoid-binding protein-induced mouse model of experimental autoimmune uveitis

Authors: Jee Myung Yang, KyungA Yun, Jehwi Jeon, Hae Young Yang, Bora Kim, Sunhong Jeong, Junyeop Lee, Wang-Yuhl Oh, Akiyoshi Uemura, Joon Seon Song, Pilhan Kim, Joo Yong Lee

Journal: Exp Mol Med

PubMed ID: 35264718

Doi: 10.1038/s12276-022-00733-z

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The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

Authors: Jindong Xu, William W Du, Nan Wu, Feiya Li, Xiangmin Li, Yizhen Xie, Sheng Wang, Burton B Yang

Journal: Mol Ther Nucleic Acids

PubMed ID: 35402068

Doi: 10.1016/j.omtn.2022.03.007

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Structural and functional analysis of the human cone-rod homeobox transcription factor

Authors: Penelope-Marie B Clanor, Christine N Buchholz, Jonathan E Hayes, Michael A Friedman, Andrew M White, Ray A Enke, Christopher E Berndsen

Journal: Proteins

PubMed ID: 35255174

Doi: 10.1002/prot.26332

Products & Services: Mammalian Expression

CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Authors: Luana Moraes, Monalisa Martins Trentini, Dimitrios Fousteris, Silas Fernandes Eto, Ana Marisa Chudzinski-Tavassi, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno

Journal: Front Immunol

PubMed ID: 35432328

Doi: 10.3389/fimmu.2022.867195

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OsASHL1 and OsASHL2, two members of the COMPASS-like complex, control floral transition and plant development in rice

Authors: Guangxin Zhao, Jingying Wang, Xi Chen, Hanjing Sha, Xin Liu, Yunfei Han, Guankai Qiu, Fantao Zhang, Jun Fang

Journal: J Genet Genomics

PubMed ID: 35306222

Doi: 10.1016/j.jgg.2022.02.026

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Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

Authors: Indrani Das Jana, Prabuddha Bhttacharya, Karthick Mayilsamy, Saptarshi Banerjee, Gourab Bhattacharje, Sayan Das, Seemanti Aditya, Anandita Ghosh, Andrew R McGill, Syamanthak Srikrishnan, Amit Kumar Das, Amit Basak, Shyam S Mohapatra, Bala Chandran, Devesh Bhimsaria, Subhra Mohapatra, Arunava Roy, Arindam Mondal

Journal: biorxiv

PubMed ID: 35313575

Doi: 10.1101/2022.03.16.484554

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mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

Authors: Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-Mao Xia, Amanda Eaton, Mattia Bonsignori, David Montefiori, Qifeng Han, Sravani Venkatayogi, Tyler Evangelous, Yunfei Wang, Wes Rountree, Bette Korber, Kshitij Wagh, Ying Tam, Christopher Barbosa, S Munir Alam, Wilton B Williams, Ming Tian, Frederick W Alt, Norbert Pardi, Drew Weissman, Barton F Haynes

Journal: Cell Rep

PubMed ID: 35294883

Doi: 10.1016/j.celrep.2022.110514

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Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

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TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis

Authors: Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhuo

Journal: Biomaterials

PubMed ID: 35378413

Doi: 10.1016/j.biomaterials.2022.121484

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Downregulation of m A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Authors: Catarina Guimarães-Teixeira, João Lobo, Vera Miranda-Gonçalves, Daniela Barros-Silva, Cláudia Martins-Lima, Sara Monteiro-Reis, José Pedro Sequeira, Isa Carneiro, Margareta P Correia, Rui Henrique, Carmen Jerónimo

Journal: Mol Oncol

PubMed ID: 35048498

Doi: 10.1002/1878-0261.13181

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Robust Pharmacology of Tmod, a Synthetic Dual-Signal Integrator for Cancer Cell Therapy

Authors: Diane Manry, Kristian Bolanos, Breanna DiAndreth, Jee-Young Mock, Alexander Kamb

Journal: Front Immunol

PubMed ID: 35359952

Doi: 10.3389/fimmu.2022.826747

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Current Status and Future Perspectives on MRNA Drug Manufacturing

Authors: Cameron Webb, Shell Ip, Nuthan V Bathula, Petya Popova, Shekinah K V Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C Ramsay, Yvonne Perrie, Anna K Blakney

Journal: Mol Pharm

PubMed ID: 35238565

Doi: 10.1021/acs.molpharmaceut.2c00010

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Protein chain collapse modulation and folding stimulation by GroEL-ES

Authors: Mohsin M Naqvi, Mario J Avellaneda, Andrew Roth, Eline J Koers, Antoine Roland, Vanda Sunderlikova, Günter Kramer, Hays S Rye, Sander J Tans

Journal: Sci Adv

PubMed ID: 35245117

Doi: 10.1126/sciadv.abl6293

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Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

Authors: Mario Fragoso-Saavedra, Carmen Ramírez-Estudillo, Diana L Peláez-González, Jorge O Ramos-Flores, Gustavo Torres-Franco, Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, María G Segura-Covarrubias, Rogelio González-González, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Amanda Gayosso-Vázquez, Silvia Reyes-Maya, Vianey Ramírez-Andoney, Rogelio A Alonso-Morales, Marco A Vega-López

Journal: Front Immunol

PubMed ID: 35432364

Doi: 10.3389/fimmu.2022.848054

Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

Authors: Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, David L Kaplan, Feng Wang, Qingyou Xia

Journal: Acta Biomater

PubMed ID: 35288310

Doi: 10.1016/j.actbio.2022.03.012

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Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Authors: Huan Yang, Caroline Sibilla, Raymond Liu, Jina Yun, Bruce A Hay, Craig Blackstone, David C Chan, Robert J Harvey, Ming Guo

Journal: Nat Commun

PubMed ID: 35332133

Doi: 10.1038/s41467-022-29071-4

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Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury

Authors: Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu

Journal: Kidney Dis (Basel)

PubMed ID: 35702708

Doi: 10.1159/000522584

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Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Authors: Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C Fragoso, Brittany N Dugger, Paul F Wilson, Matthew A Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M Monjazeb, Aijun Wang, William J Murphy, Hsing-Jien Kung, Kit S Lam, Hong-Wu Chen, Jian Jian Li

Journal: Nat Commun

PubMed ID: 35314680

Doi: 10.1038/s41467-022-29137-3

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Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

Authors: Marwa Arbi, Imen Larbi, Jihen Nsiri, Imen El Behi, Ahmed Rejeb, Khaled Miled, Adeljelil Ghram, Mehdi Houimel

Journal: Virus Res

PubMed ID: 35306102

Doi: 10.1016/j.virusres.2022.198745

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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Authors: Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang

Journal: iScience

PubMed ID: 35291264

Doi: 10.1016/j.isci.2022.104043

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KIR3DL05 and KIR3DS02 Recognition of a Nonclassical MHC Class I Molecule in the Rhesus Macaque Implicated in Pregnancy Success

Authors: Rachel E Nicholas, Kjell Sandstrom, Jennifer L Anderson, Willow R Smith, Molly Wetzel, Priyankana Banerjee, Sanath Kumar Janaka, David T Evans

Journal: Front Immunol

PubMed ID: 35401580

Doi: 10.3389/fimmu.2022.841136

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AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition

Authors: Yongchao Xie, Laixing Zhang, Zhengyu Gao, Peipei Yin, Hao Wang, Hang Li, Zeliang Chen, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nat Chem Biol

PubMed ID: 35301482

Doi: 10.1038/s41589-022-00995-8

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A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Authors: Yun Ji Park, Richard J Jodts, Jeffrey W Slater, Reyvin M Reyes, Valerie J Winton, Rana A Montaser, Paul M Thomas, William B Dowdle, Anahi Ruiz, Neil L Kelleher, J Martin Bollinger, Carsten Krebs, Brian M Hoffman, Amy C Rosenzweig

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35320042

Doi: 10.1073/pnas.2123566119

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ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma

Authors: Ji-Ye Kim, Entaz Bahar, Jung-Yun Lee, Sunhee Chang, Se Hoon Kim, Eun Young Park, Sung-Im Do, Hyonok Yoon, Hyun-Soo Kim

Journal: Cell Death Dis

PubMed ID: 35293383

Doi: 10.1038/s41419-022-04568-4

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DNA methylation in Friedreich ataxia silences expression of frataxin isoform E

Authors: Layne N Rodden, Kaitlyn M Gilliam, Christina Lam, Teerapat Rojsajjakul, Clementina Mesaros, Chiara Dionisi, Mark Pook, Massimo Pandolfo, David R Lynch, Ian A Blair, Sanjay I Bidichandani

Journal: Sci Rep

PubMed ID: 35322126

Doi: 10.1038/s41598-022-09002-5

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FSH blockade improves cognition in mice with Alzheimer's disease

Authors: Jing Xiong, Seong Su Kang, Zhihao Wang, Xia Liu, Tan-Chun Kuo, Funda Korkmaz, Ashley Padilla, Sari Miyashita, Pokman Chan, Zhaohui Zhang, Pavel Katsel, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Shan-Ping Yu, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki A Goosens, Sakshi Gera, Clifford J Rosen, Vahram Haroutunian, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye

Journal: Nature

PubMed ID: 35236988

Doi: 10.1038/s41586-022-04463-0

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Protein Electrostatics Investigated through Paramagnetic NMR for Nonpolar Groups

Authors: Binhan Yu, Channing C Pletka, Junji Iwahara

Journal: J Phys Chem B

PubMed ID: 35266708

Doi: 10.1021/acs.jpcb.1c10930

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RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Authors: Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M Kümmerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sébastien Pfeffer, Laurent Meertens, Ali Amara

Journal: J Virol

PubMed ID: 35266803

Doi: 10.1128/jvi.01962-21

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OvoA from ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities

Authors: Ronghai Cheng, Andrew C Weitz, Jared Paris, Yijie Tang, Jingyu Zhang, Heng Song, Nathchar Naowarojna, Kelin Li, Lu Qiao, Juan Lopez, Mark W Grinstaff, Lixin Zhang, Yisong Guo, Sean Elliott, Pinghua Liu

Journal: Chem Sci

PubMed ID: 35432880

Doi: 10.1039/d1sc05479a

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Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes

Authors: Colin S McHugh, Paul D Cook

Journal: Acta Crystallogr F Struct Biol Commun

PubMed ID: 35400666

Doi: 10.1107/S2053230X22002400

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Identifying Function Determining Residues in Neuroimmune Semaphorin 4A

Authors: Svetlana P Chapoval, Mariah Lee, Aaron Lemmer, Oluwaseyi Ajayi, Xiulan Qi, Andrew F Neuwald, Achsah D Keegan

Journal: Int J Mol Sci

PubMed ID: 35328445

Doi: 10.3390/ijms23063024

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Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2

Authors: Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui, Ya Bian, Sanghoon Lee, Lianjin Zhang, Byeong Chun Lee, Zhong-Hua Liu

Journal: Antioxidants (Basel)

PubMed ID: 35453372

Doi: 10.3390/antiox11040687

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MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Authors: Lu Feng, Zhengmeng Yang, Yucong Li, Qi Pan, Xiaoting Zhang, Xiaomin Wu, Jessica Hiu Tung Lo, Haixing Wang, Shanshan Bai, Xuan Lu, Ming Wang, Sien Lin, Xiaohua Pan, Gang Li

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474736

Doi: 10.1016/j.omtn.2022.03.016

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Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury

Authors: Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh, Prasad Kanteti, Jalees Rehman, Asrar B Malik

Journal: ACS Nano

PubMed ID: 35230826

Doi: 10.1021/acsnano.1c09762

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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Authors: Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin

Journal: Cell Mol Immunol

PubMed ID: 35352010

Doi: 10.1038/s41423-022-00855-4

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations

Authors: Samuel M Goodfellow, Robert A Nofchissey, Chunyan Ye, Jonathan L Dunnum, Joseph A Cook, Steven B Bradfute

Journal: Viruses

PubMed ID: 35458412

Doi: 10.3390/v14040682

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Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Authors: Michael Puckette, J Barrera, M Schwarz, M Rasmussen

Journal: BMC Biotechnol

PubMed ID: 35351081

Doi: 10.1186/s12896-022-00743-9

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Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Authors: Neha Singh, András Zeke, Attila Reményi

Journal: Int J Mol Sci

PubMed ID: 35328741

Doi: 10.3390/ijms23063320

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Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Authors: Dayana Soto, Jahir Orozco

Journal: Anal Chim Acta

PubMed ID: 35414399

Doi: 10.1016/j.aca.2022.339739

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Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Authors: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro

Journal: Nature

PubMed ID: 35264791

Doi: 10.1038/s41586-022-04487-6

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Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

Authors: Hang Yang, Huijun Yuan, Xiaohui Zhao, Meng Xun, Shangrui Guo, Nan Wang, Bing Liu, Hongliang Wang

Journal: Virol Sin

PubMed ID: 35272059

Doi: 10.1016/j.virs.2022.03.003

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Aquaporin OsPIP2;2 links the H2O2 signal and a membrane-anchored transcription factor to promote plant defense

Authors: Mou Zhang, Haotian Shi, Ningning Li, Nana Wei, Yan Tian, Jinfeng Peng, Xiaochen Chen, Liyuan Zhang, Meixiang Zhang, Hansong Dong

Journal: Plant Physiol

PubMed ID: 34958388

Doi: 10.1093/plphys/kiab604

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CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses

Authors: Bezawit A Woldemeskel, Arbor G Dykema, Caroline C Garliss, Saphira Cherfils, Kellie N Smith, Joel N Blankson

Journal: J Clin Invest

PubMed ID: 35061630

Doi: 10.1172/JCI156083

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Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Authors: Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric A Cohen, Nabil G Seidah

Journal: J Virol

PubMed ID: 35343766

Doi: 10.1128/jvi.00128-22

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SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Authors: Youri Lee, Gabrielle Grubbs, Sabrina C Ramelli, Andrea R Levine, Allison Bathula, Kapil Saharia, Madeleine Purcell, Shreya Singireddy, Colleen L Dugan, Lindsey Kirchoff, Allison Lankford, Sarah Cipriano, Ryan A Curto, Jocelyn Wu, Katherine Raja, Emily Kelley, Daniel Herr, Kevin M Vannella, Supriya Ravichandran, Juanjie Tang, Anthony Harris, Mohammad Sajadi, Daniel S Chertow, Alison Grazioli, Surender Khurana

Journal: EBioMedicine

PubMed ID: 35301181

Doi: 10.1016/j.ebiom.2022.103940

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Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Authors: Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Journal: Stem Cell Res Ther

PubMed ID: 35313965

Doi: 10.1186/s13287-022-02787-2

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CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome

Authors: Guoxin Liang, Yang He, Li Zhao, Jiayue Ouyang, Wenqing Geng, Xiaowei Zhang, Xiaoxu Han, Yongjun Jiang, Haibo Ding, Ying Xiong, Jinxiu Dong, Mei Liu, Hong Shang

Journal: Cell Rep

PubMed ID: 35294870

Doi: 10.1016/j.celrep.2022.110533

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RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates

Authors: Rabia Laghmach, Ibraheem Alshareedah, Matthew Pham, Muralikrishna Raju, Priya R Banerjee, Davit A Potoyan

Journal: iScience

PubMed ID: 35378855

Doi: 10.1016/j.isci.2022.104105

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HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Authors: Jennifer R Habel, Andrea T Nguyen, Louise C Rowntree, Christopher Szeto, Nicole A Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane Nelson, Jane Davies, Adrian Miller, Steven Y C Tong, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Luca Hensen, Katherine Kedzierska, Patricia T Illing

Journal: PLoS Pathog

PubMed ID: 35255101

Doi: 10.1371/journal.ppat.1010337

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Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators

Authors: Jürgen A Ripperger, Rohit Chavan, Urs Albrecht, Andrea Brenna

Journal: Clocks Sleep

PubMed ID: 35323171

Doi: 10.3390/clockssleep4010017

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Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress

Authors: Aijun Liu, Yonglin Zhang, Shucan Xun, Guangzhi Zhou, Li Lin, Yong Mei

Journal: Peptides

PubMed ID: 35304156

Doi: 10.1016/j.peptides.2022.170786

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The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production

Authors: Binyan Wu, Ping Li, Xiufang Hong, Cuihong Xu, Ran Wang, Yan Liang

Journal: Mol Plant

PubMed ID: 35276409

Doi: 10.1016/j.molp.2022.03.003

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Understanding desaturation/hydroxylation activity of castor stearoyl Δ9-Desaturase through rational mutagenesis

Authors: Michal Tupec , Martin Culka , Aleš Machara , Stanislav Machácˇek , Daniel Bím , Aleš Svatoš , Lubomír Rulíšek , Iva Pichová

Journal: Elsevier B.V.

Doi: 10.1016/j.csbj.2022.03.010

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Expression of a Cytochrome P450 Gene from Bermuda Grass in Soybean Confers Tolerance to Multiple Herbicides

Authors: Ting Zheng, Xiaoxing Yu, Yongzheng Sun, Qing Zhang, Xianwen Zhang, Mengzhen Tang, Chaoyang Lin, Zhicheng Shen

Journal: Plants (Basel)

PubMed ID: 35406929

Doi: 10.3390/plants11070949

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Changes in genotoxic stress response, ribogenesis and PAP (3'-phosphoadenosine 5'-phosphate) levels are associated with loss of desiccation tolerance in overprimed Medicago truncatula seeds

Authors: Andrea Pagano, Lorena Zannino, Paola Pagano, Enrico Doria, Daniele Dondi, Anca Macovei, Marco Biggiogera, Susana de Sousa Araújo, Alma Balestrazzi

Journal: Plant Cell Environ

PubMed ID: 35188276

Doi: 10.1111/pce.14295

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An ArsRC fusion protein enhances arsenate sensing and detoxification

Authors: Jian Chen, Adriana E Galván, Venkadesh Sarkarai Nadar, Masafumi Yoshinaga, Barry P Rosen

Journal: Environ Microbiol

PubMed ID: 35229439

Doi: 10.1111/1462-2920.15957

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miR-2055 regulates lipid metabolism via fatty acid synthase expression

Authors: Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zhen Zou

Journal: Open Biol

PubMed ID: 35232249

Doi: 10.1098/rsob.210307

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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender

Journal: AIDS

PubMed ID: 35084382

Doi: 10.1097/QAD.0000000000003111

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Authors: Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md Ashraf, Prince M Z Hasan, Anas Shamsi

Journal: Int J Biol Macromol

PubMed ID: 35247420

Doi: 10.1016/j.ijbiomac.2022.03.004

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Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet

Authors: Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison

Journal: J Diet Suppl

PubMed ID: 35229700

Doi: 10.1080/19390211.2022.2039340

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV15 and ranolazine reverses the phenotype

Authors: Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Journal: Clin Sci (Lond)

PubMed ID: 35190819

Doi: 10.1042/CS20211151

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Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

Authors: Jinping Wang, Xuehui Li, Yuchong Wang, Yuyu Li, Fan Shi, Hongyan Diao

Journal: Cell Death Discov

PubMed ID: 35246529

Doi: 10.1038/s41420-022-00904-x

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Structural and functional characterizations of infectivity and immune evasion of SARS-COV-2Omicron

Authors: Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tianming Chu, Leilei Feng, Yide Wang, Xinran Pei, Peng Yang, Xiaoliang Sunney Xie, Lei Cao, Yunlong Cao, Xiangxi Wang

Journal: Cell

PubMed ID: 35120603

Doi: 10.1016/j.cell.2022.01.019

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

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Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies

Authors: S Saellström, H Sharif, K K Jagarlamudi, H Rönnberg, L Wang, S Eriksson

Journal: Res Vet Sci

PubMed ID: 35245727

Doi: 10.1016/j.rvsc.2022.02.019

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling

Authors: Dan Chen, Yi Zhang, Lian Ji, Yubin Wu

Journal: Cell Biol Int

PubMed ID: 35143104

Doi: 10.1002/cbin.11777

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

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Immunological characterization of chicken tumor necrosis factor-α (TNF-α) using new sets of monoclonal antibodies specific for poultry TNF-α

Authors: Mingmin Lu, Youngsub Lee, Charles Li, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 35157961

Doi: 10.1016/j.dci.2022.104374

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Metal Dependence and Functional Diversity of Type I Cas3 Nucleases

Authors: Sining Sun, Zunyu He, Paul Jiang, Rishika Baral, Maria-Eirini Pandelia