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Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors

Authors: Jiemiao Hu, Qing Yang, Wendong Zhang, Hongwei Du, Yuhui Chen, Qingnan Zhao, Long Dao, Xueqing Xia, Fowlkes Natalie Wall, Zhongting Zhang, Kris Mahadeo, Richard Gorlick, S Kopetz, Gianpietro Dotti, Shulin Li

Journal: J Immunother Cancer

PubMed ID: 35027427

Doi: 10.1136/jitc-2021-003633

Products & Services: Mammalian Expression

Blue-light receptor phototropin 1 suppresses immunity to promote Phytophthora infestans infection

Authors: Shaista Naqvi, Qin He, Franziska Trusch, Huishan Qiu, Jasmine Pham, Qingguo Sun, John M Christie, Eleanor M Gilroy, Paul R J Birch

Journal: New Phytol

PubMed ID: 34923631

Doi: 10.1111/nph.17929

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Sterility of Sustained-release Buprenorphine

Authors: Shraddha I Cantara, Crystal Gergye, Vanessa K Lee, Michael Huerkamp

Journal: J Am Assoc Lab Anim Sci

PubMed ID: 35082006

Doi: 10.30802/AALAS-JAALAS-21-000105

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ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway

Authors: Xin Le, You-Fen Fan

Journal: J Plast Surg Hand Surg

PubMed ID: 34978504

Doi: 10.1080/2000656X.2021.2017944

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Investigation of putative antimicrobial peptides in Carassius gibel, revealing a practical approach to screening antimicrobials

Authors: Yujun Zhang, Ping Deng, Caijiao Dai, Mengke Wu, Xueqin Liu, Lijuan Li, Xiaoyi Pan, Junfa Yuan

Journal: Fish Shellfish Immunol

PubMed ID: 34990806

Doi: 10.1016/j.fsi.2021.12.050

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Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells

Authors: Bruna Cristina Falavinha, María Julia Barisón, Carmen Lúcia Kuniyoshi Rebelatto, Bruna Hilzendeger Marcon, Alessandra de Melo Aguiar, Evelin Brandão da Silva, Marco Augusto Stimamiglio, Patrícia Shigunov

Journal: Stem Cells Int

PubMed ID: 35047041

Doi: 10.1155/2022/4930932

Products & Services: ORF cDNA Clones/MolecularCloud

Inhibition of microRNA-448 suppresses CD4 T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus

Authors: Jing Zhang, Yun Guo, Yue Sun, Lihua Chang, Xiaofei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 35121374

Doi: 10.1016/j.bbrc.2022.01.097

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Hempseed () Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line

Authors: Ivan Cruz-Chamorro, Guillermo Santos-Sánchez, Carlotta Bollati, Martina Bartolomei, Jianqiang Li, Anna Arnoldi, Carmen Lammi

Journal: J Agric Food Chem

PubMed ID: 35007086

Doi: 10.1021/acs.jafc.1c07520

Products & Services: Proteins, Expression, Isolation and Analysis

NCAPH promotes cell proliferation and inhibits cell apoptosis of bladder cancer cells through MEK/ERK signaling pathway

Authors: Bo Li, Qian Xiao, Liping Shan, Yongsheng Song

Journal: Cell Cycle

PubMed ID: 34974790

Doi: 10.1080/15384101.2021.2021050

Products & Services: Plasmid DNA Preparation

Degradation of dimethachlon by a newly isolated bacterium Paenarthrobacter sp strain JH-1 relieves its toxicity against Chlorella ellipsoidea

Authors: Mingliang Zhang, Wankui Jiang, Siyuan Gao, Qian Zhu, Zhijian Ke, Mingli Jiang, Jiguo Qiu, Qing Hong

Journal: Environ Res

PubMed ID: 35031339

Doi: 10.1016/j.envres.2022.112706

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Clinical Potential of lncRNA PPP1R26-AS1 in Breast Cancer and Its Contribution to Cancer Progression

Authors: Shuping Zhou, Shaoli Zhang, Hui Zhang, Junxia Ma, Huangzhen Dai, Lili Qu, Meixiang Zhou

Journal: Mol Biotechnol

PubMed ID: 35064892

Doi: 10.1007/s12033-022-00452-w

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Mesenchymal Stem Cell-Derived Exosomes Improved Cerebral Infarction via Transferring miR-23a-3p to Activate Microglia

Authors: Chenglong Dong, Maogang Chen, Binggang Cai, Cheng Zhang, Guodong Xiao, Weifeng Luo

Journal: Neuromolecular Med

PubMed ID: 35001328

Doi: 10.1007/s12017-021-08686-8

Products & Services: ORF cDNA Clones/MolecularCloud

Genome-Wide Identification and Expression Profile Analysis of the SnRK2 Gene Family in Nicotiana tabacum

Authors: Jinghao Li, Jiangyu Song, Changjun Li, Juntao Ma, Jiawang Liu, Xiaowei Zhu, Jingchao Li, Fan He, Chao Yang

Journal: Biochem Genet

PubMed ID: 35048221

Doi: 10.1007/s10528-021-10170-8

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RBP4 regulates androgen receptor expression and steroid synthesis in Sertoli cells from Bactrian camels

Authors: Qi Wang, Quanwei Zhang, Yina Li, Xingxu Zhao, Yong Zhang

Journal: Reprod Domest Anim

PubMed ID: 35014100

Doi: 10.1111/rda.14081

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Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2

Authors: Katarzyna Piadel, Amin Haybatollahi, Angus George Dalgleish, Peter Lawrence Smith

Journal: J Gen Virol

PubMed ID: 35014605

Doi: 10.1099/jgv.0.001698

Products & Services: Peptide Synthesis

An endogenous bornavirus-like nucleoprotein in miniopterid bats retains the RNA-binding properties of the original viral protein

Authors: Yahiro Mukai, Masayuki Horie, Shohei Kojima, Junna Kawasaki, Ken Maeda, Keizo Tomonaga

Journal: FEBS Lett

PubMed ID: 35043395

Doi: 10.1002/1873-3468.14290

Products & Services: Recombinant Antibody Expression

Protocol for structure determination of SARS-CoV-2 main protease at near-physiological-temperature by serial femtosecond crystallography

Authors: Fatma Betul Ertem, Omur Guven, Cengizhan Buyukdag, Oktay Gocenler, Esra Ayan, Busra Yuksel, Mehmet Gul, Gozde Usta, Barıs Cakılkaya, J Austin Johnson, E Han Dao, Zhen Su, Frederic Poitevin, Chun Hong Yoon, Christopher Kupitz, Brandon Hayes, Mengning Liang, Mark S Hunter, Alexander Batyuk, Raymond G Sierra, Gihan Ketawala, Sabine Botha, Çağdaş Dağ, Hasan DeMirci

Journal: STAR Protoc

PubMed ID: 35194584

Doi: 10.1016/j.xpro.2022.101158

Products & Services: Proteins, Expression, Isolation and Analysis

Anion binding to a cationic europium(III) probe enables the first real-time assay of heparan sulfotransferase activity

Authors: Simon Wheeler, Colum Breen, Yong Li, Sarah H Hewitt, Erin Robertson, Edwin A Yates, Igor L Barsukov, David G Fernig, Stephen J Butler

Journal: Org Biomol Chem

PubMed ID: 34951618

Doi: 10.1039/d1ob02071d

Products & Services: Proteins, Expression, Isolation and Analysis

Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue

Authors: Yingzi Tan, Miao Wang, Yijun Chen

Journal: ACS Synth Biol

PubMed ID: 35006674

Doi: 10.1021/acssynbio.1c00578

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H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus

Authors: Miguel V Guerra, Matías I Cáceres, Andrea Herrera-Soto, Sebastián B Arredondo, Manuel Varas-Godoy, Brigitte van Zundert, Lorena Varela-Nallar

Journal: Front Cell Dev Biol

PubMed ID: 35096813

Doi: 10.3389/fcell.2021.778345

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Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Authors: Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez, Jean-Jacques Diaz

Journal: Nat Commun

PubMed ID: 35013311

Doi: 10.1038/s41467-021-27847-8

Products & Services: PCR Cloning and Subcloning

CD46 Isoforms Influence the Mode of Entry by Human Herpesvirus 6A/B in T Cells

Authors: Litten Sørensen Rossen, Vivien R Schack, Katrine Kyd Holstein Thuesen, Bettina Bundgaard, Per Höllsberg

Journal: J Virol

PubMed ID: 35019717

Doi: 10.1128/JVI.01557-21

Products & Services: Proteins, Expression, Isolation and Analysis

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy

Authors: D P Tonge, D Darling, F Farzaneh, G T Williams

Journal: Sci Rep

PubMed ID: 34997014

Doi: 10.1038/s41598-021-03983-5

Products & Services: Plasmid DNA Preparation

Comparison of Carbonic Anhydrases for CO Sequestration

Authors: Franziska Steger, Johanna Reich, Werner Fuchs, Simon K-M R Rittmann, Georg M Gübitz, Doris Ribitsch, Günther Bochmann

Journal: Int J Mol Sci

PubMed ID: 35055147

Doi: 10.3390/ijms23020957

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Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Authors: Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K Shoemark, A Sofia F Oliveira, David A Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K N Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J Mulholland, Andrew D Davidson, Christiane Schaffitzel, Imre Berger

Journal: Nat Commun

PubMed ID: 35017512

Doi: 10.1038/s41467-021-27881-6

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A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in

Authors: Andrés Martin Bellido, Ayelén Mariana Distéfano, Nicolás Setzes, María Milagros Cascallares, Jana Oklestkova, Ondrej Novak, Javier Alberto Ramirez, Eduardo J Zabaleta, Diego F Fiol, Gabriela C Pagnussat

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35046016

Doi: 10.1073/pnas.2000482119

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Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Authors: Yannik Bollen, Joris H Hageman, Petra van Leenen, Lucca L M Derks, Bas Ponsioen, Julian R Buissant des Amorie, Ingrid Verlaan-Klink, Myrna van den Bos, Leon W M M Terstappen, Ruben van Boxtel, Hugo J G Snippert

Journal: PLoS Biol

PubMed ID: 35089911

Doi: 10.1371/journal.pbio.3001527

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Ultrasound-mediated gene delivery of factor VIII plasmids for hemophilia A gene therapy in mice

Authors: Shuxian Song, Meghan J Lyle, Misty L Noble-Vranish, Dominic M Min-Tran, James Harrang, Weidong Xiao, Evan C Unger, Carol H Miao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35141050

Doi: 10.1016/j.omtn.2022.01.006

Products & Services: Plasmid DNA Preparation

Humoral Immune Response in IBD Patients Three and Six Months after Vaccination with the SARS-CoV-2 mRNA Vaccines mRNA-1273 and BNT162b2

Authors: Richard Vollenberg, Phil-Robin Tepasse, Joachim Ewald Kühn, Marc Hennies, Markus Strauss, Florian Rennebaum, Tina Schomacher, Göran Boeckel, Eva Lorentzen, Arne Bokemeyer, Tobias Max Nowacki

Journal: Biomedicines

PubMed ID: 35052849

Doi: 10.3390/biomedicines10010171

Immunity to Sda1 Protects against Infection by Sda1 and Sda1 Serotypes of Group A

Authors: Shuai Bi, Jie Wang, Meiyi Xu, Ning Li, Beinan Wang

Journal: Vaccines (Basel)

PubMed ID: 35062763

Doi: 10.3390/vaccines10010102

Products & Services: Proteins, Expression, Isolation and Analysis

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

Authors: Juexiao Gong, Man Luo, Yonghong Yong, Shan Zhong, Peng Li

Journal: Cell Death Discov

PubMed ID: 35022384

Doi: 10.1038/s41420-022-00822-y

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Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

Authors: Naroa Serna, Aïda Falgàs, Annabel García-León, Ugutz Unzueta, Yáiza Núñez, Alejandro Sánchez-Chardi, Carlos Martínez-Torró, Ramón Mangues, Esther Vazquez, Isolda Casanova, Antonio Villaverde

Journal: Pharmaceutics

PubMed ID: 35057088

Doi: 10.3390/pharmaceutics14010192

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy

Authors: Manon Locatelli, Flavien Delhaes, Ophélie Cherpin, Margaret E Black, Stéphanie Carnesecchi, Olivier Preynat-Seauve, Youssef Hibaoui, Karl-Heinz Krause

Journal: Cells

PubMed ID: 35159311

Doi: 10.3390/cells11030502

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Zika virus baculovirus-expressed envelope protein elicited humoral and cellular immunity in immunocompetent mice

Authors: Minna Shin, Kiju Kim, Hyo-Ji Lee, Rangyeon Lee, Yu-Jin Jung, Jeongho Park, Tae-Wook Hahn

Journal: Sci Rep

PubMed ID: 35027643

Doi: 10.1038/s41598-021-04713-7

Products & Services: Proteins, Expression, Isolation and Analysis

BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence

Authors: Soumita Dutta, Ileana D Corsi, Naomi Bier, Theresa M Koehler

Journal: MBio

PubMed ID: 35073743

Doi: 10.1128/mbio.03640-21

Products & Services: Proteins, Expression, Isolation and Analysis

Effects of the Chloroplast Fructose-1,6-Bisphosphate Aldolase Gene on Growth and Low-Temperature Tolerance of Tomato

Authors: Bingbing Cai, Yu Ning, Qiang Li, Qingyun Li, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 35054921

Doi: 10.3390/ijms23020728

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Plant expression systems as an economical alternative for the production of iELISA coating antigen AHSV VP7

Authors: Shelley H Fearon, Susan J Dennis, Inga I Hitzeroth, Edward P Rybicki, Ann E Meyers

Journal: N Biotechnol

PubMed ID: 35114407

Doi: 10.1016/j.nbt.2022.01.009

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Hyperproduction of PHA copolymers containing high fractions of 4-hydroxybutyrate (4HB) by outer membrane-defected Halomonas bluephagenesis grown in bioreactors

Authors: Ziyu Wang, Yifei Zheng, Mengke Ji, Xu Zhang, Huan Wang, Yuemeng Chen, Qiong Wu, Guo-Qiang Chen

Journal: Microb Biotechnol

PubMed ID: 34978757

Doi: 10.1111/1751-7915.13999

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SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons

Authors: Hila Asraf, Milos Bogdanovic, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel

Journal: iScience

PubMed ID: 35118363

Doi: 10.1016/j.isci.2022.103751

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Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1

Authors: Qi Sun, Yufen Wang, Adam Officer, Brianna Pecknold, Garrett Lee, Olivier Harismendy, Jay S Desgrosellier

Journal: NPJ Breast Cancer

PubMed ID: 35027548

Doi: 10.1038/s41523-021-00375-w

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Proline-specific aminopeptidase P prevents replication-associated genome instability

Authors: Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez

Journal: PLoS Genet

PubMed ID: 35081133

Doi: 10.1371/journal.pgen.1010025

Products & Services: Proteins, Expression, Isolation and Analysis

Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9

Authors: Ali Movahedi, Hui Wei, Xiaohong Zhou, Jake C Fountain, Zhong-Hua Chen, Zhiying Mu, Weibo Sun, Jiaxin Zhang, Dawei Li, Baozhu Guo, Rajeev K Varshney, Liming Yang, Qiang Zhuge

Journal: Hortic Res

PubMed ID: 36133672

Doi: 10.1093/hr/uhac154

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USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma

Authors: Yang Chen, Yin Zhao, Xiaojing Yang, Xianyue Ren, Shengyan Huang, Sha Gong, Xirong Tan, Junyan Li, Shiwei He, Yingqin Li, Xiaohong Hong, Qian Li, Cong Ding, Xueliang Fang, Jun Ma, Na Liu

Journal: Nat Commun

PubMed ID: 35079021

Doi: 10.1038/s41467-022-28158-2

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Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

Authors: Lucía Barbier-Torres, Ben Murray, Jin Won Yang, Jiaohong Wang, Michitaka Matsuda, Aaron Robinson, Aleksandra Binek, Wei Fan, David Fernández-Ramos, Fernando Lopitz-Otsoa, Maria Luque-Urbano, Oscar Millet, Nirmala Mavila, Hui Peng, Komal Ramani, Roberta Gottlieb, Zhaoli Sun, Suthat Liangpunsakul, Ekihiro Seki, Jennifer E Van Eyk, Jose M Mato, Shelly C Lu

Journal: Nat Commun

PubMed ID: 35091576

Doi: 10.1038/s41467-022-28201-2

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Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes

Authors: Melody Gao, D Alex Johnson, Isabel M Piper, Hanna M Kodama, Justin E Svendsen, Elise Tahti, Frederick Longshore-Neate, Brandon Vogel, John M Antos, Jeanine F Amacher

Journal: Protein Sci

PubMed ID: 34939250

Doi: 10.1002/pro.4266

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A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca signalling through IP receptors

Authors: Andrew R Lavik, Karen S McColl, Fernanda O Lemos, Martijn Kerkhofs, Fei Zhong, Michael Harr, Daniela Schlatzer, Kozo Hamada, Katsuhiko Mikoshiba, Francesco Crea, Geert Bultynck, Martin D Bootman, Jan B Parys, Clark W Distelhorst

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35026348

Doi: 10.1016/j.bbamcr.2021.119206

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MicroRNA analysis reveals the role of miR-214 in duck adipocyte differentiation

Authors: Laidi Wang, Xiaodan Hu, Shasha Wang, Chunyou Yuan, Zhixiu Wang, Guobin Chang, Guohong Chen

Journal: Anim Biosci

PubMed ID: 35073666

Doi: 10.5713/ab.21.0441

Products & Services: Proteins, Expression, Isolation and Analysis

Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant

Authors: Khadija Khan, Farina Karim, Sandile Cele, James Emmanuel San, Gila Lustig, Houriiyah Tegally, Yuval Rosenberg, Mallory Bernstein, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Nokuthula Ngcobo, Yoliswa Miya, Matilda Mazibuko, Ntombifuthi Mthabela, Zoey Mhlane, Nikiwe Mbatha, Jennifer Giandhari, Yajna Ramphal, Taryn Naidoo, Nithendra Manickchund, Nombulelo Magula, Salim Abdool Karim, Glenda Gray, Willem Hanekom, Anne von Gottberg, Ron Milo, Bernadett Gosnell, Richard Lessells, Tulio de Oliveira, Penny Moore, Yunus S Moosa, Alex Sigal

Journal: medrxiv

PubMed ID: 34981076

Doi: 10.1101/2021.12.27.21268439

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Quantitation of Trastuzumab and an Antibody to SARS-CoV-2 in Minutes Using Affinity Membranes in 96-Well Plates

Authors: Hui Yin Tan, Junyan Yang, Jacqueline C Linnes, Christopher J Welch, Merlin L Bruening

Journal: Anal Chem

PubMed ID: 34982935

Doi: 10.1021/acs.analchem.1c03654

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Development of a radioiodinated thioflavin-T-Congo-red hybrid probe for diagnosis of systemic amyloidosis

Authors: Yoshie Haratake, Kohei Sano, Miki Tsuchiya, Kaori Minaki, Masayuki Munekane, Toshihide Yamasaki, Masayori Hagimori, Takahiro Mukai

Journal: Bioorg Med Chem

PubMed ID: 35033883

Doi: 10.1016/j.bmc.2021.116591

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A network of Gα signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF

Authors: Naincy R Chandan, Saji Abraham, Shuvasree SenGupta, Carole A Parent, Alan V Smrcka

Journal: Sci Signal

PubMed ID: 35041463

Doi: 10.1126/scisignal.abi9869

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Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma

Authors: Sofie Kirial Mørk, Mohammad Kadivar, Kalijn Fredrike Bol, Arianna Draghi, Marie Christine Wulff Westergaard, Signe Koggersbøl Skadborg, Nana Overgaard, Anders Bundgård Sørensen, Ida Svahn Rasmussen, Lars Vibe Andreasen, Christina Westmose Yde, Thomas Trolle, Christian Garde, Jens Friis-Nielsen, Nis Nørgaard, Dennis Christensen, Jens Vindahl Kringelum, Marco Donia, Sine Reker Hadrup, Inge Marie Svane

Journal: Oncoimmunology

PubMed ID: 35036074

Doi: 10.1080/2162402X.2021.2023255

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Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide

Authors: Nathalie Vanderheijden, Annelies Stevaert, Jiexiong Xie, Xiaolei Ren, Cyril Barbezange, Sam Noppen, Isabelle Desombere, Bruno Verhasselt, Peter Geldhof, Nick Vereecke, Veerle Stroobants, Dayoung Oh, Merijn Vanhee, Lieve M J Naesens, Hans J Nauwynck

Journal: Front Immunol

PubMed ID: 35069571

Doi: 10.3389/fimmu.2021.790415

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Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Authors: Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen

Journal: iScience

PubMed ID: 35118359

Doi: 10.1016/j.isci.2022.103746

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CRISPR/Cas12a Technology Combined With RPA for Rapid and Portable SFTSV Detection

Authors: Mengqian Huang, Sihua Liu, Yanan Xu, Aqian Li, Wei Wu, Mifang Liang, Guoyu Niu, Zhiyun Wang, Tao Wang

Journal: Front Microbiol

PubMed ID: 35145502

Doi: 10.3389/fmicb.2022.754995

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Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity

Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang

Journal: Cell Calcium

Doi: doi.org/10.1016/j.ceca.2022.102538

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RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern

Authors: Shi-Hao Zhou 1 , Ru-Yan Zhang, Hai-Wei Zhang, Yan-Ling Liu, Yu Wen, Jian Wang, Yu-Ting Li, Zi-Wei You, Xu-Guang Yin, Hong Qiu, Rui Gong, Guang-Fu Yang, Jun Guo

Journal: Chem Commun (Camb)

PubMed ID: 35040862

Doi: 10.1039/d1cc06520c

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A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control

Authors: Griffin M Schroeder, Chapin E Cavender , Maya E Blau, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind

Journal: Nat Commun

PubMed ID: 35017488

Doi: 10.1038/s41467-021-27790-8

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Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: the inhibitory role of receptor N-glycosylation

Authors: Sangmin Lee

Journal: Peptides

PubMed ID: 35007660

Doi: 10.1016/j.peptides.2022.170735

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Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability

Authors: Bo Yang, Bojie Xu,Ruicheng Yang, Jiyang Fu, Liang Li, Dong Huo,Jiaqi Chen, Xiaopei Yang,Chen Tan,Huanchun Chen and Xiangru Wang

Journal: Mol Neurobiol

PubMed ID: 34985734

Doi: 10.1007/s12035-021-02690-6

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A VLP-Based Vaccine Candidate Protects Mice against Japanese Encephalitis Virus Infection

Authors: Limin Yang , Aibo Xiao , Hu Wang , Xiaojuan Zhang , Yuan Zhang , Yunlong Li, Yanqiu Wei , Wenjun Liu , Chuangfu Chen

Journal: Vaccines (Basel)

PubMed ID: 35214656

Doi: 10.3390/vaccines10020197

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Computer-Informed Engineering a New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of Unusual C10-(S)- Bicyclogermacrene

Authors: Xiaoguang Yan, Jiahui Zhou, Jianjun Ge, Weiguo Li, Dongmei Liang, Warispreet Singh, Gary Black, Shengxin Nie, Jian Liu, Meiqing Sun, Jianjun Qiao, and Meilan Huang

Journal: ACS catalysis

Doi: 10.1021/acscatal.2c00013

Products & Services: Proteins, Expression, Isolation and Analysis

The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c-di-GMP

Authors: Ya Gao , Yurui Xu , Yanyan Li , Kerong Chen , Xiaotong Wu , Yuhang Liu , Xuli Feng , Desheng Kong , Xinghai Ning

Journal: Nano Lett

PubMed ID: 34994567

Doi: 10.1021/acs.nanolett.1c03970

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Plasmodium falciparum Kelch13 and its artemisinin-resistant mutants assemble as hexamers in solution: a SAXS data-driven modelling study

Authors: Nainy Goel, Kanika Dhiman, Nidhi Kalidas, Anwesha Mukhopadhyay, Fnu Ashish, Souvik Bhattacharjee

Journal: FEBS J

PubMed ID: 35092154

Doi: 10.1111/febs.16378

Products & Services: Proteins, Expression, Isolation and Analysis

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies

Authors: Jeong A Park, Nai-Kong V Cheung

Journal: J Immunother Cancer

PubMed ID: 35086947

Doi: 10.1136/jitc-2021-003771

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Fukutin regulates tau phosphorylation and synaptic function: Novel properties of fukutin in neurons

Authors: Ryota Tsukui, Tomoko Yamamoto, Yukinori Okamura, Yoichiro Kato, Noriyuki Shibata

Journal: Neuropathology

PubMed ID: 35026860

Doi: 10.1111/neup.12797

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Backbone NMR assignment of the nucleotide binding domain of the Bacillus subtilis ABC multidrug transporter BmrA in the post-hydrolysis state

Authors: Victor Hugo Pérez Carrillo, Dania Rose-Sperling, Mai Anh Tran, Christoph Wiedemann, Ute A Hellmich

Journal: Biomol NMR Assign

PubMed ID: 34988902

Doi: 10.1007/s12104-021-10063-2

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Expression, Purification, and Biophysical Characterization of Klebsiella Pneumoniae Nicotinate Nucleotide Adenylyltransferase

Authors: Tasvi Daya, Olamide Jeje, Reabetswe Maake, Chinyere Aloke, Thandeka Khoza, Ikechukwu Achilonu

Journal: Protein J

PubMed ID: 35083643

Doi: 10.1007/s10930-021-10037-2

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Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus

Authors: Liqi Liu, Zi Li, Jianfang Zhou, Jia Liu, Xiyan Li, Weijuan Huang, Ning Xiao, Dayan Wang

Journal: Influenza Other Respir Viruses

PubMed ID: 35037399

Doi: 10.1111/irv.12954

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Formation of β-Strand Oligomers of Antimicrobial Peptide Magainin 2 Contributes to Disruption of Phospholipid Membrane

Authors: Munehiro Kumashiro, Ryoga Tsuji, Shoma Suenaga, Koichi Matsuo

Journal: Membranes (Basel)

PubMed ID: 35207051

Doi: 10.3390/membranes12020131

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Inhibiting L1CAM Reverses Cisplatin Resistance of Triple Negative Breast Cancer Cells by Blocking AKT Signaling Pathway

Authors: Lu-Yao Zhang, Zhi-Xin Shen, Lu Guo

Journal: Cancer Invest

PubMed ID: 35040385

Doi: 10.1080/07357907.2021.2016801

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Formation of β-Strand Oligomers of Antimicrobial Peptide Magainin 2 Contributes to Disruption of Phospholipid Membrane

Authors: Munehiro Kumashiro, Ryoga Tsuji, Shoma Suenaga, Koichi Matsuo

Journal: Membranes (Basel)

PubMed ID: 35207051

Doi: 10.3390/membranes12020131

Products & Services: Peptide Synthesis

Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis

Authors: Qian Guo, Tingting Guo, Yuanyuan Sun, Tianrong Chen

Journal: Neuroreport

PubMed ID: 34874325

Doi: 10.1097/WNR.0000000000001743

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Hempseed () Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line

Authors: Ivan Cruz-Chamorro, Guillermo Santos-Sánchez, Carlotta Bollati, Martina Bartolomei, Jianqiang Li, Anna Arnoldi, Carmen Lammi

Journal: J Agric Food Chem

PubMed ID: 35007086

Doi: 10.1021/acs.jafc.1c07520

Products & Services: Proteins, Expression, Isolation and Analysis

Bio-nanocapsules for oriented immobilization of DNA aptamers on aptasensors

Authors: Masumi Iijima, Yuki Yamada, Hideo Nakano, Tsutomu Nakayama, Shun'ichi Kuroda

Journal: Analyst

PubMed ID: 35023508

Doi: 10.1039/d1an02278d

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The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential

Authors: Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-Chen Wang, Lei Wang

Journal: Redox Biol

PubMed ID: 35077997

Doi: 10.1016/j.redox.2022.102244

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Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence

Authors: Stefano Perni, Kurt Beam

Journal: J Gen Physiol

PubMed ID: 35089322

Doi: 10.1085/jgp.202113024

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Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles

Authors: Yueyue Duan, Liyan Cao, Cong Yuan, Xuepeng Suo, Xiangyu Kong, Yulong Gao, Xiangtong Li, Haixue Zheng, Xiaomei Wang, Qi Wang

Journal: MBio

PubMed ID: 35038897

Doi: 10.1128/mbio.03287-21

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Conditional Alternative Protein Splicing Promoted by Inteins from

Authors: Vaishnavi R Yalala, Abigeal K Lynch, Kenneth V Mills

Journal: Biochemistry

PubMed ID: 35073064

Doi: 10.1021/acs.biochem.1c00788

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Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity

Authors: Ming Xia, Md Rejaul Hoq, Pengwei Huang, Wen Jiang, Xi Jiang, Ming Tan

Journal: Nano Res

PubMed ID: 35106126

Doi: 10.1007/s12274-021-4011-x

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Trichodysplasia spinulosa polyomavirus small T antigen synergistically modulates S6 protein translation and DNA damage response pathways to shape host cell environment

Authors: Deepika Narayanan, Danyal Tahseen, Brooke R Bartley, Stephen A Moore, Rebecca Simonette, Peter L Rady, Stephen K Tyring

Journal: Virus Genes

PubMed ID: 35000075

Doi: 10.1007/s11262-021-01880-7

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Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity

Authors: Ming Xia, Md Rejaul Hoq, Pengwei Huang, Wen Jiang, Xi Jiang, Ming Tan

Journal: Nano Res

PubMed ID: 35106126

Doi: 10.1007/s12274-021-4011-x

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HOTAIR Induces the Downregulation of miR-200 Family Members in Gastric Cancer Cell Lines

Authors: Fatemeh Bossaghzadeh, Mohammadreza Hajjari, Abdolkarim Sheikhi, Iman Salahshourifar, Shiva Irani

Journal: Iran Biomed J

PubMed ID: 34923813

Doi: 10.52547/ibj.26.1.77

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Formation of Calprotectin-Derived Peptides in the Airways of Children with Cystic Fibrosis

Authors: Teagan S Edwards, Nina Dickerhof, Nicholas J Magon, Louise N Paton, Peter D Sly, Anthony J Kettle

Journal: J Immunol

PubMed ID: 35046105

Doi: 10.4049/jimmunol.2001017

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Genome-Wide Identification and Expression Profile Analysis of the SnRK2 Gene Family in Nicotiana tabacum

Authors: Jinghao Li, Jiangyu Song, Changjun Li, Juntao Ma, Jiawang Liu, Xiaowei Zhu, Jingchao Li, Fan He, Chao Yang

Journal: Biochem Genet

PubMed ID: 35048221

Doi: 10.1007/s10528-021-10170-8

Products & Services: Protein Tools

Development of an enzymatic method for the evaluation of protein deposition on contact lenses

Authors: Simin Masoudi, Mark Willcox

Journal: Biofouling

PubMed ID: 35016572

Doi: 10.1080/08927014.2021.2019225

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A Micrarchaeon isolate is covered by a proteinaceous S-Layer

Authors: Sabrina Gfrerer, Dennis Winkler, Julia Novion Ducassou, Yohann Couté, Reinhard Rachel, Johannes Gescher

Journal: Appl Environ Microbiol

PubMed ID: 35020453

Doi: 10.1128/AEM.01553-21

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A Micrarchaeon isolate is covered by a proteinaceous S-Layer

Authors: Sabrina Gfrerer, Dennis Winkler, Julia Novion Ducassou, Yohann Couté, Reinhard Rachel, Johannes Gescher

Journal: Appl Environ Microbiol

PubMed ID: 35020453

Doi: 10.1128/AEM.01553-21

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The Novel microRNA Rno-miR-686-3p Is Associated with the Ischaemic Penumbra

Authors: Wei Wang, Jin-Pin Li, Jing-Li Liu

Journal: Eur Neurol

PubMed ID: 35100587

Doi: 10.1159/000521491

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Survey of SARS-CoV-2 in dogs and cats in high-risk areas during the second wave of COVID-19 outbreak, Thailand

Authors: Waleemas Jairak, Kamonpan Charoenkul, Ekkapat Chamsai, Kitikhun Udom, Supassama Chaiyawong, Aphinya Hangsawek, Suchart Waenkaew, Anek Mungaomklang, Ratanaporn Tangwangvivat, Alongkorn Amonsin

Journal: Zoonoses Public Health

PubMed ID: 34981900

Doi: 10.1111/zph.12907

Safety and Immunogenicity of the Third Booster Dose with Inactivated, Viral Vector, and mRNA COVID-19 Vaccines in Fully Immunized Healthy Adults with Inactivated Vaccine

Authors: Sitthichai Kanokudom, Suvichada Assawakosri, Nungruthai Suntronwong, Chompoonut Auphimai, Pornjarim Nilyanimit, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Ritthideach Yorsaeng, Donchida Srimuan, Thaksaporn Thatsanatorn, Sirapa Klinfueng, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Sittisak Honsawek, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 35062747

Doi: 10.3390/vaccines10010086

Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway

Authors: Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentini

Journal: Mol Neurobiol

PubMed ID: 35044626

Doi: 10.1007/s12035-022-02748-z

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In vivo HSC gene therapy for SARS-CoV2 infection using a decoy receptor

Authors: Hongjie Wang, Chang Li, Adebimpe Obadan, Hannah Frizzell, Tien-Ying Hsiang, Sucheol Gil, Audrey Germond, Connie Fountain, Audrey Baldessari, Steve Roffler, Hans-Peter Kiem, Deborah Fuller, Andre Lieber

Journal: Hum Gene Ther

PubMed ID: 35057635

Doi: 10.1089/hum.2021.295

Products & Services: Recombinant Antibody Expression

Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3

Authors: Jie Zhang, Miaomiao Li, Yunwen Ou, Danian Chen, Yaozhong Ding, Weibing Zhang, Yanjun Li, Qian Hou, Xiaoyun Li, Luoyi Zhou, Katarzyna Podgorska, Alexei D Zaberezhny, Anna Szczotka-Bochniarz, Yongsheng Liu, Yang Wang

Journal: Front Microbiol

PubMed ID: 35095787

Doi: 10.3389/fmicb.2021.758064

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Optimization of loop-mediated isothermal amplification (LAMP) assay for robust visualization in SARS-CoV-2 and emerging variants diagnosis

Authors: Zhen Luo, Chunhong Ye, Heng Xiao, Jialing Yin, Yicong Liang, Zhihui Ruan, Danju Luo, Daolong Gao, Qiuping Tan, Yongkui Li, Qiwei Zhang, Weiyong Liu, Jianguo Wu

Journal: Chem Eng Sci

PubMed ID: 35043022

Doi: 10.1016/j.ces.2022.117430

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miR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy

Authors: Yujie Guo, Xiaoyan Xu, Tian Tang, Lin Sun, Xiong Zhang, Xia Shen, Dan Li, Lixin Wang, Libo Zhao, Peng Xie

Journal: J Gen Virol

PubMed ID: 35060474

Doi: 10.1099/jgv.0.001713

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Prognostic significance of a complement factor H autoantibody in early stage NSCLC

Authors: Elizabeth B Gottlin, Michael J Campa, Rikesh Gandhi, Ryan T Bushey, James E Herndon, Edward F Patz

Journal: Cancer Biomark

PubMed ID: 35068447

Doi: 10.3233/CBM-210355

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An AAV vaccine targeting the RBD of the SARS-CoV-2 S protein induces effective neutralizing antibody titers in mice and canines

Authors: Fei Liu, Canbin Feng, Shiqi Xu, Qiang Wu, Jian Tang, Yan Chen, Ruisheng Xu, Fuliang Chen, Ni Gao, Zhengzheng Xu, Shihui Gu, Yang Lan, Haibo Zhou, Xinde Hu, Xiaojing Wang

Journal: Vaccine

PubMed ID: 35094871

Doi: 10.1016/j.vaccine.2022.01.030

Products & Services: Mammalian Expression

ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway

Authors: Xin Le, You-Fen Fan

Journal: J Plast Surg Hand Surg

PubMed ID: 34978504

Doi: 10.1080/2000656X.2021.2017944

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Downregulation of estrogen receptor-α36 expression attenuates metastasis of hepatocellular carcinoma cells

Authors: Ruobing Wang, Jiaming Chen, Haiyan Yu, Zhixuan Wei, Min Ma, Xueyan Ye, Weiqi Wu, Hongfei Chen, Zhengqi Fu

Journal: Environ Toxicol

PubMed ID: 35044086

Doi: 10.1002/tox.23469

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