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Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target

Authors: Kendra J. Gallo; Nicolas J. Wheeler; Abdifatah M. Elmi; Paul M. Airs; Mostafa Zamanian

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 36602350

Doi: 10.1128/aac.01188-22

Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice

Authors: Zhi Li, Ning Wu, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang

Journal: Int J Biol Macromol

PubMed ID: 35841956

Doi: doi.org/10.1016/j.ijbiomac.2022.07.053

Products & Services: Protein Electrophoresis and Western

Genome-wide CRISPR Screening Reveals Pyrimidine Metabolic Reprogramming in 5-FU Chronochemotherapy of Colorectal Cancer

Authors: Ya Niu, Xinyi Fan, Yaping Wang, Jiaxin Lin, Luchun Hua, Xiaobo Li, Ruizhe Qian, Chao Lu

Journal: Front Oncol

PubMed ID: 35903686

Doi: 10.3389/fonc.2022.949715

Products & Services: Recombinant Proteins

Oral Administration with Recombinant Attenuated Regulated Delayed Lysis Vaccines Protecting against Kidney Abscess Formation

Authors: Yanchen Liang, Haochi Zhang, Na Pan, Yang Liu, Shouxin Sheng, Haotian Li, Xuemei Bao, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 35891237

Doi: 10.3390/vaccines10071073

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Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing

Authors: Lennart Hoengenaert, Marlies Wouters, Hoon Kim, Barbara De Meester, Kris Morreel, Steven Vandersyppe, Jacob Pollier, Sandrien Desmet, Geert Goeminne, John Ralph, Wout Boerjan, Ruben Vanholme

Journal: Sci Adv

PubMed ID: 35857515

Doi: 10.1126/sciadv.abo5738

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A time-resolved, multi-symbol molecular recorder via sequential genome editing

Authors: Junhong Choi, Wei Chen, Anna Minkina, Florence M Chardon, Chase C Suiter, Samuel G Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M Daza, Jay Shendure

Journal: Nature

PubMed ID: 35794474

Doi: 10.1038/s41586-022-04922-8

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Pharmacokinetic Characteristics, Safety, and Tolerability of Telitacicept, an Injectable Recombinant Human B-Lymphocyte Stimulating Factor Receptor-Antibody Fusion Protein, in Healthy Chinese Subjects

Authors: Jing Xie, Xiaoyun Fan, Yue Su, Huan Zhou, Shugang Cao, Xingyu Zhu, Minhui Zhu, Cuixia He, Ying Wang, Ling Fan, Qin Ge, Juan Zhu, Bingyan Liu, Xiao Chen, Yunqiu Xie, Ling Ma, Yuanyuan Liu, Juan Chen, Huaxue Wang, Zhijun Li

Journal: Clin Pharmacol Drug Dev

PubMed ID: 35844038

Doi: 10.1002/cpdd.1136

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A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry

Authors: Liangqin Tong, Lin Wang, Shumin Liao, Xiaoping Xiao, Jing Qu, Chunli Wu, Yibin Zhu, Wanbo Tai, Yanhong Huang, Penghua Wang, Liang Li, Renli Zhang, Ye Xiang, Gong Cheng

Journal: MBio

PubMed ID: 35862773

Doi: 10.1128/mbio.01485-22

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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Authors: Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio

Journal: Pharmaceuticals (Basel)

PubMed ID: 35890155

Doi: 10.3390/ph15070855

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Mycoplasma hyopneumoniae membrane protein Mhp271 interacts with host UPR protein GRP78 to facilitate infection

Authors: Qiao Pan, Qingyuan Xu, Tong Liu, Yujuan Zhang, Jiuqing Xin

Journal: Mol Microbiol

PubMed ID: 35791781

Doi: 10.1111/mmi.14963

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Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach

Authors: Theo Battista, Stefano Federico, Simone Brogi, Luca Pozzetti, Tuhina Khan, Stefania Butini, Anna Ramunno, Eleonora Fiorentino, Stefania Orsini, Trentina Di Muccio, Annarita Fiorillo, Cécile Exertier, Daniel Di Risola, Gianni Colotti, Sandra Gemma, Andrea Ilari, Giuseppe Campiani

Journal: ACS Infect Dis

PubMed ID: 35880849

Doi: 10.1021/acsinfecdis.2c00325

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Grp94 Works Upstream of BiP in Protein Remodeling Under Heat Stress

Authors: Yaa S Amankwah, Preston Collins, Yasmeen Fleifil, Erin Unruh, Kevin J Ruiz Márquez, Katherine Vitou, Andrea N Kravats

Journal: J Mol Biol

PubMed ID: 35905823

Doi: 10.1016/j.jmb.2022.167762

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Proteomic and Phosphoproteomic Analyses Reveal Gibel Carp Responses to Cyprinid Herpesvirus 2 Infection

Authors: Chen Xu, Yiqun Li, Zidong Xiao, Jie Yang, Mingyang Xue, Nan Jiang, Yan Meng, Wenzhi Liu, Yuding Fan, Yong Zhou

Journal: J Proteome Res

PubMed ID: 35792615

Doi: 10.1021/acs.jproteome.2c00253

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Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

Authors: Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Journal: J Physiol Biochem

PubMed ID: 35902547

Doi: 10.1007/s13105-022-00901-9

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Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter

Authors: Deepthi Joseph, Smruti Ranjan Nayak, Aravind Penmatsa

Journal: EMBO J

PubMed ID: 35796008

Doi: 10.15252/embj.2022110735

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Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines

Authors: Brianna M Doratt, Elizabeth Vance, Delphine C Malherbe, Mark T W Ebbert, Ilhem Messaoudi

Journal: Front Cell Infect Microbiol

PubMed ID: 35959363

Doi: 10.3389/fcimb.2022.943587

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A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever

Authors: Robert W Cross, Courtney Woolsey, Abhishek N Prasad, Viktoriya Borisevich, Krystle N Agans, Daniel J Deer, Joan B Geisbert, Natalie S Dobias, Karla A Fenton, Thomas W Geisbert

Journal: Cell Rep

PubMed ID: 35858566

Doi: 10.1016/j.celrep.2022.111094

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SARS-CoV-2 Delta spike protein enhances the viral fusogenicity and inflammatory cytokine production

Authors: Zhujun Ao, Maggie Jing Ouyang, Titus Abiola Olukitibi, Xiaojian Yao

Journal: iScience

PubMed ID: 35854977

Doi: 10.1016/j.isci.2022.104759

Products & Services: Plasmid DNA Preparation

Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information

Authors: James M Heather, Matthew J Spindler, Marta Herrero Alonso, Yifang Ivana Shui, David G Millar, David S Johnson, Mark Cobbold, Aaron N Hata

Journal: Nucleic Acids Res

PubMed ID: 35325179

Doi: 10.1093/nar/gkac190

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A biepitope, adjuvant-free, self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice

Authors: Yongbo Qiao, YaXin Zhang, Jie Chen, Shenghui Jin, Yaming Shan

Journal: Nano Res

PubMed ID: 35911479

Doi: 10.1007/s12274-022-4482-4

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Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers

Authors: Xiuling Gu, Yufan Zhang, Wei Jiang, Dongfang Wang, Jiao Lu, Guanglei Gu, Chengfeng Qin, Min Fang

Journal: Vaccines (Basel)

PubMed ID: 35891248

Doi: 10.3390/vaccines10071084

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A hydrogel platform for co-delivery of immunomodulatory proteins for pancreatic islet allografts

Authors: Juan D Medina, Graham F Barber, Maria M Coronel, Michael D Hunckler, Stephen W Linderman, Michelle J Quizon, Vahap Ulker, Esma S Yolcu, Haval Shirwan, Andrés J García

Journal: J Biomed Mater Res A

PubMed ID: 35841329

Doi: 10.1002/jbm.a.37429

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Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma

Authors: Shoshana T Levi, Amy R Copeland, Shirley Nah, Jessica S Crystal, Gabriel D Ivey, Almin Lalani, Mohammad Jafferji, Bradley S White, Neilesh B Parikh, Vid Leko, Sri Krishna, Frank Lowery, Todd D Prickett, Jared J Gartner, Li Jia, Yong F Li, Abraham Sachs, Sivasish Sindiri, Welles Robinson, Billel Gasmi, James C Yang, Stephanie L Goff, Steven A Rosenberg, Paul F Robbins

Journal: Clin Cancer Res

PubMed ID: 35247926

Doi: 10.1158/1078-0432.CCR-21-4499

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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals

Authors: Zehra Karakoese, Mara Schwerdtfeger, Christina B Karsten, Stefan Esser, Ulf Dittmer, Kathrin Sutter

Journal: Front Immunol

PubMed ID: 35911692

Doi: 10.3389/fimmu.2022.936918

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Structural insight into apelin receptor-G protein stoichiometry

Authors: Yang Yue , Lier Liu , Li-Jie Wu , Yiran Wu , Ling Wang , Fei Li , Junlin Liu , Gye-Won Han , Bo Chen , Xi Lin , Rebecca L Brouillette , Émile Breault , Jean-Michel Longpré , Songting Shi , Hui Lei , Philippe Sarret , Raymond C Stevens , Michael A Hanson , Fei Xu

Journal: Nat Struct Mol Biol

PubMed ID: 35817871

Doi: 10.1038/s41594-022-00797-5

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Purification, characterization, and preliminary serial crystallography diffraction advances structure determination of full-length human particulate guanylyl cyclase A receptor

Authors: Shangji Zhang, Debra T Hansen, Jose M Martin-Garcia, James D Zook, Shuchong Pan, Felicia M Craciunescu, John C Burnett, Petra Fromme

Journal: Sci Rep

PubMed ID: 35821229

Doi: 10.1038/s41598-022-15798-z

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gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

Authors: Ying Zhang, Alexander J Vontz, Ethan M Kallenberger, Xin Xu, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Berhane Ghebrehiwet, Brian V Geisbrecht

Journal: Front Immunol

PubMed ID: 35865516

Doi: 10.3389/fimmu.2022.887742

Products & Services: Mammalian Expression

[C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease

Authors: Tharick A Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Joseph Therriault, Firoza Z Lussier, Frederick A Schroeder, Jonathan M DuBois, Baileigh G Hightower, Tonya M Gilbert, Nicole R Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T Hyman, Bradford C Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M Hooker, Pedro Rosa-Neto

Journal: Nat Commun

PubMed ID: 35853847

Doi: 10.1038/s41467-022-30653-5

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Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes.

Authors: Uxue Ballesteros , Asier Etxaniz , Marina N Iriondo , Yaiza R Varela , Melisa Lázaro , Ana R Viguera , L Ruth Montes , Mikel Valle , Félix M Goñi , Alicia Alonso

Journal: Int J Biol Macromol

PubMed ID: 35618088

Doi: 10.1016/j.ijbiomac.2022.05.129.

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Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant

Authors: Gen Li , Zhongcheng Zhou , Peng Du , Meixiao Zhan , Ning Li 1、, Xinxin Xiong , Shengjun Tang , Miao Man, Daniel T Baptista-Hon, Ligong Lu

Journal: Signal Transduct Target Ther

PubMed ID: 35853864

Doi: 10.1038/s41392-022-01062-3.

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Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

Authors: Xingxing Li , Liuqing He , Jianhua Luo , Yangling Zheng , Yao Zhou , Danyang Li , Yuanyuan Zhang , Zhenrui Pan , Yanyan Li , Liang Tao

Journal: Nat Commun

PubMed ID: 35882856

Doi: 10.1038/s41467-022-31994-x

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Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission

Authors: Yi Cao , Clifford T H Hayashi , Fidel Zavala , Abhai K Tripathi , Hayk Simonyan , Colin N Young , Leor C Clark , Yukari Usuda , Jacob M Van Parys , Nirbhay Kumar

Journal: Vaccines (Basel)

PubMed ID: 35891298

Doi: 10.3390/vaccines10071134

Products & Services: Plasmid DNA Preparation

One-pot isothermal LAMP-CRISPR-based assay for Klebsiella pneumoniae detection

Authors: Xiaotong Qiu , Xueping Liu , Xiao Ma , Ruixue Wang , Shenglin Chen , Fang Li , Zhenjun Li

Journal: Microbiol Spectr

PubMed ID: 35856669

Doi: 10.1128/spectrum.01545-22

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Direct adenylation from 5?-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase

Authors: Zhengquan Yang , Chengliang Zhang , Guojun Lian , Shijie Dong , Menghui Song , Hengrong Shao , Jingmei Wang , Tao Zhong , Zhenni Luo , Shengnan Jin , Chunming Ding

Journal: Nucleic Acids Res

PubMed ID: 35819229

Doi: org/10.1093/nar/gkac604

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Structural insights into the activation of neurokinin 2 receptor by neurokinin A

Authors: Wenjing Sun , Qingning Yuan , Huanhuan Zhang , Fan Yang , Shenglong Ling , Yifan Luo , Pei Lv , H Eric Xu , Changlin Tian , Wanchao Yin , Pan Shi

Journal: Cell Discov

PubMed ID: 35882833

Doi: 10.1038/s41421-022-00437-8

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Discrimination between Different DNA Lesions by Monitoring Single-Molecule Polymerase Stalling Kinetics during Nanopore Sequencing

Authors: Jinyue Zhang , Yu Wang , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: Nano Lett

PubMed ID: 35713465

Doi: 10.1021/acs.nanolett.2c01833

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Development of a Multi-Epitope Vaccine for and Evaluation of Its Immune Responses in Mice and Piglets

Authors: Gaojian Li, Jinqi Shu, Jing Jin, Jianhong Shu, Huapeng Feng, Jian Chen, Yulong He

Journal: Int J Mol Sci

PubMed ID: 35887246

Doi: 10.3390/ijms23147899

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Microfluidic Paper-Based Preconcentration and Retrieval for Rapid Ribonucleic Acid Biomarker Detection and Visualization

Authors: Yannan Yu, Fengya Fan, Zachary J Smith, Xi Wei

Journal: Anal Chem

PubMed ID: 35858837

Doi: 10.1021/acs.analchem.2c01442

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Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

Authors: Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Yu Jiang, Sheng Yang

Journal: Sci China Life Sci

PubMed ID: 35907113

Doi: 10.1007/s11427-021-2137-3

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Biglycan neo-epitope (BGN), a novel biomarker for screening early changes in equine osteoarthritic subchondral bone

Authors: S Adepu, S Ekman, J Leth, U Johansson, A Lindahl, E Skiöldebrand

Journal: Osteoarthritis Cartilage

PubMed ID: 35870736

Doi: 10.1016/j.joca.2022.07.005

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Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model

Authors: Kyle Rosenke, Atsushi Okumura, Matthew C Lewis, Friederike Feldmann, Kimberly Meade-White, W Forrest Bohler, Amanda Griffin, Rebecca Rosenke, Carl Shaia, Michael A Jarvis, Heinz Feldmann

Journal: JCI Insight

PubMed ID: 35579953

Doi: 10.1172/jci.insight.160108

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HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Authors: Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers, Laura Fumagalli, Lieselot Dedeene, Matthieu Moisse, Ilse Geudens, Nicole Hersmus, Arpan R Mehta, Bhuvaneish T Selvaraj, Siddharthan Chandran, Ritchie Ho, Dietmar R Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 35895140

Doi: 10.1007/s00401-022-02471-y

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KIL1 terminates fertility in maize by controlling silk senescence

Authors: M Ria Šim Škov, Anna Daneva, Nicolas Doll, Neeltje Schilling, Marta Cubr A-Rad O, Liangzi Zhou, Freya De Winter, Stijn Aesaert, Riet De Rycke, Laurens Pauwels, Thomas Dresselhaus, Norbert Brugi Re, Carl R Simmons, Jeffrey E Habben, Moritz K Nowack

Journal: Plant Cell

PubMed ID: 35608197

Doi: 10.1093/plcell/koac151

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Cap Is the Protease of the Porcine Circovirus 2

Authors: Xuechen Yang, Wei Yang, Wei Zhang, Jiamei Li, Guoyu Yang, Shuhong Zhao, Yueting Zheng

Journal: Viruses

PubMed ID: 35891530

Doi: 10.3390/v14071550

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The structure of Vibrio cholerae FeoC reveals conservation of the helix-turn-helix motif but not the cluster-binding domain

Authors: Janae B Brown, Mark A Lee, Aaron T Smith

Journal: J Biol Inorg Chem

PubMed ID: 35796835

Doi: 10.1007/s00775-022-01945-4

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Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26COV2S

Authors: Dominique J Barbeau, Judith M Martin, Emily Carney, Emily Dougherty, Joshua D Doyle, Terence S Dermody, Alejandro Hoberman, John V Williams, Marian G Michaels, John F Alcorn, W Paul Duprex, Anita K McElroy

Journal: npj Vaccines

PubMed ID: 35794181

Doi: 10.1038/s41541-022-00504-x

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A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins

Authors: Noureddine Lazar, Carl H Mesarich, Yohann Petit-Houdenot, Nacera Talbi, Ines Li de la Sierra-Gallay, Emilie Zélie, Karine Blondeau, Jérôme Gracy, Bénédicte Ollivier, Françoise Blaise, Thierry Rouxel, Marie-Hélène Balesdent, Alexander Idnurm, Herman van Tilbeurgh, Isabelle Fudal

Journal: PLoS Pathog

PubMed ID: 35793393

Doi: 10.1371/journal.ppat.1010664

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Combined strategies for suppressing nonspecific cationic adduction to G-quadruplexes in electrospray ionization mass spectrometry

Authors: Wen Lei, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu

Journal: Anal Chim Acta

PubMed ID: 35868693

Doi: 10.1016/j.aca.2022.340146

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Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS

Authors: Wen Chen, Dickson Kirui, Nancy J Millenbaugh

Journal: Future Sci OA

PubMed ID: 35909998

Doi: 10.2144/fsoa-2022-0013

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CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1

Authors: Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu

Journal: Theranostics

PubMed ID: 35836803

Doi: 10.7150/thno.72365

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Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

Authors: Asif Alam Chowdhury, Nachiket M Godbole, Neha Chataut, Stanley Kosanke, Karla Rodgers, Shanjana Awasthi

Journal: Physiol Rep

PubMed ID: 35838161

Doi: 10.14814/phy2.15353

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Humanin derivative, HNG, enhances neurotransmitter release

Authors: Natsumi Ikegawa, Ayari Kozuka, Nozomi Morita, Minetaka Murakami, Nobuyuki Sasakawa, Takako Niikura

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 35843407

Doi: 10.1016/j.bbagen.2022.130204

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Connexin 43 overexpression induces lung cancer angiogenesis following phosphorylation at Ser279 in its C-terminus

Authors: Zizi Zhou, Wenxiang Chai, Yi Liu, Yao Liu, Huiyu Pan, Qiang Wu, Xiaoming Zhang

Journal: Oncol Lett

PubMed ID: 35949588

Doi: 10.3892/ol.2022.13413

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Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients

Authors: L Sánchez-Ruano, C Fernández-Lozano, M Ferrer, F Gómez, B de la Hoz, J Martínez-Botas, M J Goikoetxea

Journal: Front Allergy

PubMed ID: 35935018

Doi: 10.3389/falgy.2022.896617

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Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Authors: Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao

Journal: Nat Commun

PubMed ID: 35879296

Doi: 10.1038/s41467-022-32000-0

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A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

Authors: Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li

Journal: Virol Sin

PubMed ID: 35835315

Doi: 10.1016/j.virs.2022.07.003

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Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells

Authors: Yichen Wu, Min Chen, Zilong Chen, Jiangcheng Shu, Luoying Zhang, Jiong Hu, Hongjun Yu, Kai Huang, Minglu Liang

Journal: Front Pharmacol

PubMed ID: 35903325

Doi: 10.3389/fphar.2022.861319

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Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Authors: Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W Chu, Dennis R Voelker, Monica Kraft, Julie G Ledford

Journal: Front Immunol

PubMed ID: 35874703

Doi: 10.3389/fimmu.2022.900022

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Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding

Authors: Kim-Marie A Dam, Patricia S Mutia, Pamela J Bjorkman

Journal: Sci Rep

PubMed ID: 35778473

Doi: 10.1038/s41598-022-15506-x

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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Authors: Clint M Upchurch, Scott Yeudall, Caitlin M Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S Raghavan, Irina M Bochkis, Michael M Scott, Edward Perez-Reyes, Norbert Leitinger

Journal: Sci Adv

PubMed ID: 35857497

Doi: 10.1126/sciadv.abn0050

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Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals

Authors: Armel Landry Batchi-Bouyou, Jean Claude Djontu, Jeannhey Christevy Vouvoungui, Claujens Chastel Mfoutou Mapanguy, Line Lobaloba Ingoba, Jiré Séphora Mougany, Kamal Rauchelvy Boumpoutou, Steve Diafouka-Kietela, Raoul Ampa, Francine Ntoumi

Journal: BMC Infect Dis

PubMed ID: 35831798

Doi: 10.1186/s12879-022-07593-y

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A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Authors: Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Journal: Cancer Res Commun

PubMed ID: 35937460

Doi: 10.1158/2767-9764.crc-21-0084

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A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

Authors: Brooke D Huisman, Zheng Dai, David K Gifford, Michael E Birnbaum

Journal: Elife

PubMed ID: 35781135

Doi: 10.7554/eLife.78589

Products & Services: Recombinant Antibody Expression

Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles

Authors: Shani Bekker, Henk Huismans, Vida van Staden

Journal: Viruses

PubMed ID: 35893692

Doi: 10.3390/v14081624

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The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Authors: Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G F Rasmussen, Magnus Andersson, Tristan Croll, Kamil Gotfryd, Pontus Gourdon

Journal: Sci Adv

PubMed ID: 35857505

Doi: 10.1126/sciadv.abn4331

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Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae

Authors: Jimstan Periselneris, Carolin T Turner, Giuseppe Ercoli, Gabriella Szylar, Caroline M Weight, Teresa Thurston, Matthew Whelan, Gillian Tomlinson, Mahdad Noursadeghi, Jeremy Brown

Journal: Immunology

PubMed ID: 35835695

Doi: 10.1111/imm.13546

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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

Authors: Xinlei Zhuang, Zhe Wang, Jiansheng Fan, Xuefei Bai, Yingchun Xu, James J Chou, Tingjun Hou, Shuqing Chen, Liqiang Pan

Journal: Nat Commun

PubMed ID: 35907884

Doi: 10.1038/s41467-022-32159-6

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Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade

Authors: Peter H Wang, Robert Washburn, Rohan Maniar, Michael Mu, Olivia Ringham, Radomir Kratchmarov, Brian S Henick, Steven L Reiner

Journal: J Immunol

PubMed ID: 35905999

Doi: 10.4049/jimmunol.2200317

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Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein

Authors: Mohammad Islamuddin, Abuzer Ali, Wajihul Hasan Khan, Amena Ali, Syed Kazim Hasan, Mohd Abdullah, Kentaro Kato, Malik Zainul Abdin, Shama Parveen

Journal: Infect Drug Resist

PubMed ID: 35924014

Doi: 10.2147/IDR.S347545

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Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase

Authors: Felipe A M Otsuka, Sinisa Bjelic

Journal: Protein Sci

PubMed ID: 35762721

Doi: 10.1002/pro.4354

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Proteomic Network of Antibiotic-Induced Outer Membrane Vesicles Released by Extensively Drug-Resistant Elizabethkingia anophelis

Authors: Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen

Journal: Microbiol Spectr

PubMed ID: 35852325

Doi: 10.1128/spectrum.00262-22

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HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Matthew D Surette, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright

Journal: Mol Cell

PubMed ID: 35907401

Doi: 10.1016/j.molcel.2022.06.019

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Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Authors: Huiyun Liu, Daniel Heller-Trulli, Claire L Moore

Journal: iScience

PubMed ID: 35992060

Doi: 10.1016/j.isci.2022.104804

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Phase transition modulation and biophysical characterization of biomolecular condensates using microfluidics

Authors: Katherine W Y Chan, Maryam Navi, Jennifer Kieda, Thomas Moran, Daniel Hammers, Shaun Lee, Scott S H Tsai

Journal: Lab Chip

PubMed ID: 35616128

Doi: 10.1039/d2lc00037g

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A cell-free paper-based biosensor dependent on allosteric transcription factors (aTFs) for on-site detection of harmful metals Hg and Pb in water

Authors: Yongkang Zhang, Chen Zhao, Huaixiu Bi, Xi Zhang, Bin Xue, Chenyu Li, Shang Wang, Xiaobo Yang, Zhigang Qiu, Jingfeng Wang, Zhiqiang Shen

Journal: J Hazard Mater

PubMed ID: 35816794

Doi: 10.1016/j.jhazmat.2022.129499

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BioWF: A Naturally-Fused, Di-Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope

Authors: Shona M Richardson, Peter J Harrison, Michael A Herrera, Menglu Wang, Rebecca Verez, Gustavo Perez Ortiz, Dominic J Campopiano

Journal: Chembiochem

PubMed ID: 35695820

Doi: 10.1002/cbic.202200171

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PLAA suppresses ovarian cancer metastasis via METTL3-mediated mA modification of TRPC3 mRNA

Authors: Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu

Journal: Oncogene

PubMed ID: 35869392

Doi: 10.1038/s41388-022-02411-w

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Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant and

Authors: Ifeoluwa D Gbala, Rosaline W Macharia, Joel L Bargul, Gabriel Magoma

Journal: Molecules

PubMed ID: 35889198

Doi: 10.3390/molecules27144325

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FOXM1 regulates glycolysis and energy production in multiple myeloma

Authors: Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A Katzenellenbogen, Benita S Katzenellenbogen, Parameswaran Hari, Siegfried Janz

Journal: Oncogene

PubMed ID: 35794249

Doi: 10.1038/s41388-022-02398-4

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Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage

Authors: Diana Lin, Darcy Sutherland, Sambina Islam Aninta, Nathan Louie, Ka Ming Nip, Chenkai Li, Anat Yanai, Lauren Coombe, René L Warren, Caren C Helbing, Linda M N Hoang, Inanc Birol

Journal: Antibiotics (Basel)

PubMed ID: 35884206

Doi: 10.3390/antibiotics11070952

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CROWN ROOTLESS1 binds DNA with a relaxed specificity and activates OsROP and OsbHLH044 genes involved in crown root formation in rice

Authors: Mathieu Gonin, Kwanho Jeong, Yoan Coudert, Jeremy Lavarenne, Giang Thi Hoang, Martine Bes, Huong Thi Mai To, Marie-Rose Ndella Thiaw, Toan Van Do, Daniel Moukouanga, Soazig Guyomarc'h, Kevin Bellande, Jean-Rémy Brossier, Boris Parizot, Hieu Trang Nguyen, Tom Beeckman, Véronique Bergougnoux, Jacques Rouster, Christophe Sallaud, Laurent Laplaze, Antony Champion, Pascal Gantet

Journal: Plant J

PubMed ID: 35596715

Doi: 10.1111/tpj.15838

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Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines

Authors: Zi-Wei Ye, Yilan Fan, Kaiming Tang, Chon Phin Ong, Cuiting Luo, Hon-Lam Chung, Tsun-Lam Leong, Ronghui Liang, Wai-Yin Lui, Runhong Zhou, Yun Cheng, Lu Lu, Pak-Hin Hinson Cheung, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Shuofeng Yuan, Kelvin Kai-Wang To, Dong-Yan Jin

Journal: Int J Biol Sci

PubMed ID: 35874942

Doi: 10.7150/ijbs.72109

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

Authors: Ryan J Boyd, Tien L Olson, James D Zook, Derek Stein, Manuel Aceves, Wan-Hsin Lin, Felicia M Craciunescu, Debra T Hansen, Panos Z Anastasiadis, Abhishek Singharoy, Petra Fromme

Journal: FASEB J

PubMed ID: 35639414

Doi: 10.1096/fj.202101808RR

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Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target

Authors: Kendra J. Gallo; Nicolas J. Wheeler; Abdifatah M. Elmi; Paul M. Airs; Mostafa Zamanian

Journal: Antimicrobial Agents and Chemotherapy

PubMed ID: 36602350

Doi: 10.1128/aac.01188-22

PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells

Authors: Fan Ye, Yucui Jiang, Yingxin Zong, Jian Zhang, Chan Zhu, Yan Yang, Zongxiang Tang

Journal: Immunol Lett

PubMed ID: 35714789

Doi: 10.1016/j.imlet.2022.06.006

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The Texture Change of Chinese Traditional Pig Trotter with Soy Sauce during Stewing Processing: Based on a Thermal Degradation Model of Collagen Fibers

Authors: Yuhai Lin, Ying Wang, Guofeng Jin, Junjie Duan, Yuemei Zhang, Jinxuan Cao

Journal: Foods

PubMed ID: 35741970

Doi: 10.3390/foods11121772

Products & Services: Molecular Biology Reagents

A cytosolic pentatricopeptide repeat protein is essential for tapetal plastid development by regulating OsGLK1 transcript levels in rice

Authors: Shaoyan Zheng , Jingfang Dong , Jingqin Lu , Jing Li , Dagang Jiang , Haopeng Yu , Simiao Ye , Wenli Bu , Zhenlan Liu , Hai Zhou , Yiliang Ding , Chuxiong Zhuang

Journal: New Phytol .

PubMed ID: 35306663

Doi: 10.1111/nph.18105

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Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies

Authors: Araceli Aguilar-González, Juan Elías González-Correa, Eliana Barriocanal-Casado, Iris Ramos-Hernández, Miguel A Lerma-Juárez, Sara Greco, Juan José Rodríguez-Sevilla, Francisco Javier Molina-Estévez, Valle Montalvo-Romeral, Giuseppe Ronzitti, Rosario María Sánchez-Martín, Francisco Martín, Pilar Muñoz

Journal: Int J Mol Sci

PubMed ID: 35682977

Doi: 10.3390/ijms23116298

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Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

Authors: Xin-Zi Emily Tang, Shu Xuan Tan, Shawn Hoon, Gene W Yeo

Journal: Nat Med

PubMed ID: 35668177

Doi: 10.1038/s41591-022-01848-6

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COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir

Authors: Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin L Dewar, Sophie E M Kelly, Heather Kalish, Tauseef Rehman, Jeroen Highbarger, Adam Rupert, Gregory Kocher, Michael R Holbrook, Andrea Lisco, Maura Manion, Richard A Koup, Irini Sereti

Journal: medrxiv

PubMed ID: 35734093

Doi: 10.1101/2022.06.16.22276392

Identification of Antigenic Properties of Acinetobacter baumannii Proteins as Novel Putative Vaccine Candidates Using Reverse Vaccinology Approach

Authors: Tohid Piri-Gharaghie, Abbas Doosti, Seyed Abbas Mirzaei

Journal: Appl Biochem Biotechnol

PubMed ID: 35670904

Doi: 10.1007/s12010-022-03995-5

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Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish

Authors: Sarah LaPotin, Mary E Swartz, David M Luecke, Savvas J Constantinou, Jason R Gallant, Johann K Eberhart, Harold H Zakon

Journal: Sci Adv

PubMed ID: 35648851

Doi: 10.1126/sciadv.abm2970

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Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochem J

PubMed ID: 35670457

Doi: 10.1042/BCJ20220037

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Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy

Authors: Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo

Journal: J Immunol

PubMed ID: 35725271

Doi: 10.4049/jimmunol.2100938

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Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)

Authors: Johannes C van der Mijn, Qiuying Chen, Kristian B Laursen, Francesca Khani, Xiaofei Wang, Princesca Dorsaint, Andrea Sboner, Steven S Gross, David M Nanus, Lorraine J Gudas

Journal: Mol Carcinog

PubMed ID: 35726553

Doi: 10.1002/mc.23437

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Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

Authors: Amy R Rappaport, Sue-Jean Hong, Ciaran D Scallan, Leonid Gitlin, Arvin Akoopie, Gregory R Boucher, Milana Egorova, J Aaron Espinosa, Mario Fidanza, Melissa A Kachura, Annie Shen, Gloria Sivko, Anne Van Abbema, Robert L Veres, Karin Jooss

Journal: Nat Commun

PubMed ID: 35672369

Doi: 10.1038/s41467-022-31005-z

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Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma

Authors: Victor O Oria, Hongyi Zhang, Christopher R Zito, Chetan K Rane, Xian-Yong Ma, Olivia K Provance, Thuy T Tran, Adebowale Adeniran, Yuval Kluger, Mario Sznol, Marcus W Bosenberg, Harriet M Kluger, Lucia B Jilaveanu

Journal: Cell Mol Life Sci

PubMed ID: 35737114

Doi: 10.1007/s00018-022-04364-5

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Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186

Authors: Danielle E Dettling, Eilene Kwok, Lucy Quach, Aakash Datt, Jeremiah D Degenhardt, Anand Panchal, Pui Seto, Jessica L Krakow, Russell Wall, Brian J Hillier, Ying Zhu, Maia Vinogradova, Robert B DuBridge, Chad May

Journal: J Immunother Cancer

PubMed ID: 35728872

Doi: 10.1136/jitc-2021-004336

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Molecular insights into intra-complex signal transmission during stressosome activation

Authors: Algirdas Miksys, Lifei Fu, M Gregor Madej, Duarte N Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J Lewis, Conor O'Byrne, Jan Pané-Farré, Christine Ziegler

Journal: Commun Biol

PubMed ID: 35760945

Doi: 10.1038/s42003-022-03549-9

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SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues

Authors: Siqian Feng, Richard S Mann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696584

Doi: 10.1073/pnas.2122900119

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