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HOTAIR Induces the Downregulation of miR-200 Family Members in Gastric Cancer Cell Lines

Authors: Fatemeh Bossaghzadeh, Mohammadreza Hajjari, Abdolkarim Sheikhi, Iman Salahshourifar, Shiva Irani

Journal: Iran Biomed J

PubMed ID: 34923813

Doi: 10.52547/ibj.26.1.77

Products & Services: Molecular Biology Tools

Anagliptin prevents lipopolysaccharide (LPS)- induced inflammation and activation of macrophages

Authors: Fangfang Yu, Wenxia Tian, Jie Dong

Journal: Int Immunopharmacol

PubMed ID: 35045357

Doi: 10.1016/j.intimp.2021.108514

Products & Services: Gene Synthesis

Development of an enzymatic method for the evaluation of protein deposition on contact lenses

Authors: Simin Masoudi, Mark Willcox

Journal: Biofouling

PubMed ID: 35016572

Doi: 10.1080/08927014.2021.2019225

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Penetration of the SARS-CoV-2 Spike Protein across the Blood-Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical Biosensing

Authors: Dániel Petrovszki, Fruzsina R Walter, Judit P Vigh, Anna Kocsis, Sándor Valkai, Mária A Deli, András Dér

Journal: Biomedicines

PubMed ID: 35052867

Doi: 10.3390/biomedicines10010188

Products & Services: Monoclonal Antibody Services

Deletion of Specific Conserved Motifs from the N-Terminal Domain of B-Crystallin Results in the Activation of Chaperone Functions

Authors: Sundararajan Mahalingam Goutham Shankar, Brian P. Mooney, Kamal Singh, Puttur Santhoshkumar, and Krishna K. Sharma

Journal: International Journal of Molecular Sciences

Doi: 10.3390/ijms23031099

Products & Services: Gene Synthesis Gene Synthesis

Functionality of a bicistronic construction containing and genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

Authors: Alisa A Shaimardanova, Daria S Chulpanova, Valeriya V Solovyeva, Aleksandr M Aimaletdinov, Albert A Rizvanov

Journal: Neural Regen Res

PubMed ID: 34100447

Doi: 10.4103/1673-5374.314310

Products & Services: Gene Synthesis

Predictive Factors for Neutralizing Antibody Levels Nine Months after Full Vaccination with BNT162b2: Results of a Machine Learning Analysis

Authors: Dimitris Papadopoulos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Zoi Evangelakou, Panagiotis Malandrakis, Maria S Manola, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos, Vangelis Karalis, Evangelos Terpos

Journal: Biomedicines

PubMed ID: 35203412

Doi: 10.3390/biomedicines10020204

Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether

Authors: Elise S Bruguera, Jacob P Mahoney, William I Weis

Journal: J Biol Chem

PubMed ID: 35074428

Doi: 10.1016/j.jbc.2022.101628

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In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Authors: Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard

Journal: Nat Commun

PubMed ID: 35058427

Doi: 10.1038/s41467-022-27974-w

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SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease

Authors: Stefania Colarusso, Federica Ferrigno, Simona Ponzi, Francesca Pavone, Immacolata Conte, Luigi Abate, Elisa Beghetto, Antonino Missineo, Jerome Amaudrut, Alberto Bresciani, Giacomo Paonessa, Licia Tomei, Christian Montalbetti, Elisabetta Bianchi, Carlo Toniatti, Jesus M Ontoria

Journal: Bioorg Med Chem

PubMed ID: 35123179

Doi: 10.1016/j.bmc.2022.116631

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Recombinant Pap31 for the Diagnosis of Canine and Human Bartonelloses

Authors: Pradeep Neupane, Ricardo G Maggi, Manoj Basnet, Erin Lashnits, Gerard P Andrews, Edward B Breitschwerdt

Journal: Pathogens

PubMed ID: 35215127

Doi: 10.3390/pathogens11020182

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of the human ATM kinase and mechanism of Nbs1 binding

Authors: Christopher Warren, Nikola P Pavletich

Journal: Elife

PubMed ID: 35076389

Doi: 10.7554/eLife.74218

Products & Services: Mammalian Expression

Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19

Authors: Mihaela Chivu-Economescu, Coralia Bleotu, Camelia Grancea, Daniela Chiriac, Anca Botezatu, Iulia V Iancu, Ioana Pitica, Laura G Necula, Ana Neagu, Lilia Matei, Denisa Dragu, Camelia Sultana, Elena L Radu, Alina Nastasie, Oana Voicu, Marius Ataman, Saviana Nedeianu, Cristina Mambet, Carmen C Diaconu, Simona Maria Ruta

Journal: J Cell Mol Med

PubMed ID: 35043552

Doi: 10.1111/jcmm.17186

Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases

Authors: Rong Chen, Lin Zhao, Rong Gan, Zhixin Feng, Chenxi Cui, Xing Xie, Fei Hao, Zhenzhen Zhang, Li Wang, Tingting Ran, Weiwu Wang, Shuijun Zhang, Yufeng Li, Wei Zhang, Maoda Pang, Qiyan Xiong, Guoqing Shao

Journal: Front Mol Biosci

PubMed ID: 35145997

Doi: 10.3389/fmolb.2021.811106

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Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

Authors: Charles A Specht, E Jane Homan, Chrono K Lee, Zhongming Mou, Christina L Gomez, Maureen M Hester, Ambily Abraham, Florentina Rus, Gary R Ostroff, Stuart M Levitz

Journal: MBio

PubMed ID: 35089095

Doi: 10.1128/mbio.03367-21

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Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering

Authors: Yile Hao, Qinhua Wang, Jie Li, Shihui Yang, Yanli Zheng, Wenfang Peng

Journal: Open Biol

PubMed ID: 35016549

Doi: 10.1098/rsob.210241

Products & Services: Plasmid DNA Preparation

Transcriptome analysis of Leucojum aestivum and identification of genes involved in norbelladine biosynthesis

Authors: Laurence Tousignant, Aracely Maribel Diaz-Garza, Bharat Bhusan Majhi, Sarah-Eve Gélinas, Aparna Singh, Isabel Desgagne-Penix

Journal: Planta

PubMed ID: 34981205

Doi: 10.1007/s00425-021-03741-x

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Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer

Authors: Junko Matsuzaki, Shashikant Lele, Kunle Odunsi, Takemasa Tsuji

Journal: Oncoimmunology

PubMed ID: 35003898

Doi: 10.1080/2162402X.2021.2020983

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Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer

Authors: Junko Matsuzaki, Shashikant Lele, Kunle Odunsi, Takemasa Tsuji

Journal: Oncoimmunology

PubMed ID: 35003898

Doi: 10.1080/2162402X.2021.2020983

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Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus

Authors: Liqi Liu, Zi Li, Jianfang Zhou, Jia Liu, Xiyan Li, Weijuan Huang, Ning Xiao, Dayan Wang

Journal: Influenza Other Respir Viruses

PubMed ID: 35037399

Doi: 10.1111/irv.12954

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The H, N and C resonance assignments of the low-complexity domain from the oncogenic fusion protein EWS-FLI1

Authors: Courtney N Johnson, Xiaoping Xu, Stephen P Holloway, David S Libich

Journal: Biomol NMR Assign

PubMed ID: 34994941

Doi: 10.1007/s12104-021-10061-4

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Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells

Authors: Bruna Cristina Falavinha, María Julia Barisón, Carmen Lúcia Kuniyoshi Rebelatto, Bruna Hilzendeger Marcon, Alessandra de Melo Aguiar, Evelin Brandão da Silva, Marco Augusto Stimamiglio, Patrícia Shigunov

Journal: Stem Cells Int

PubMed ID: 35047041

Doi: 10.1155/2022/4930932

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The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione

Authors: Mana Murae, Yoshimi Shimizu, Yuichiro Yamamoto, Asuka Kobayashi, Masumi Houri, Tetsuya Inoue, Takuya Irie, Ryutaro Gemba, Yosuke Kondo, Yoshio Nakano, Satoru Miyazaki, Daisuke Yamada, Akiyoshi Saitoh, Isao Ishii, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi

Journal: Biochem Biophys Res Commun

PubMed ID: 35123263

Doi: 10.1016/j.bbrc.2022.01.106

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The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione

Journal: Biochem Biophys Res Commun

PubMed ID: 35123263

Doi: 10.1016/j.bbrc.2022.01.106

Products & Services: Monoclonal Antibody Services

Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles

Authors: Yueyue Duan, Liyan Cao, Cong Yuan, Xuepeng Suo, Xiangyu Kong, Yulong Gao, Xiangtong Li, Haixue Zheng, Xiaomei Wang, Qi Wang

Journal: MBio

PubMed ID: 35038897

Doi: 10.1128/mbio.03287-21

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LbCas12a-D156R Efficiently Edits Effector Binding Elements to Generate Canker-Resistant Citrus Plants

Authors: Hongge Jia, Yuanchun Wang, Hang Su, Xiaoen Huang, Nian Wang

Journal: Cells

PubMed ID: 35159125

Doi: 10.3390/cells11030315

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Heterologous immunization with BNT162b2 followed by mRNA-1273 in dialysis patients: seroconversion and presence of neutralizing antibodies

Authors: Niko Kohmer, Holger F Rabenau, Sandra Ciesek, Bernhard K Krämer, Uwe Göttmann, Christine Keller, Daniela Rose, Carsten Blume, Michael Thomas, Alexander Lammert, Anne Lammert

Journal: Nephrol Dial Transplant

PubMed ID: 35099023

Doi: 10.1093/ndt/gfac018

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SARS-CoV-2 Seroprevalence Among Whole Blood Donors During First Wave of Covid-19 Pandemic in India

Authors: Srinivasa Rao Chunchu, Ushasree Ravula, Vikram Kumar Gente, Srinivas Bacchu, S Pandu Ranga Rao, Srujaleswari Mooli

Journal: Indian J Hematol Blood Transfus

PubMed ID: 35125705

Doi: 10.1007/s12288-021-01512-y

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UM171A-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells

Authors: Natasha Salame, Jean-Pierre Bikorimana, Nehme El-Hachem, Wael Saad, Mazen Kurdi, Jing Zhao, Nicoletta Eliopoulos, Riam Shammaa, Moutih Rafei

Journal: Stem Cell Res Ther

PubMed ID: 35012668

Doi: 10.1186/s13287-021-02693-z

Products & Services: Peptide Synthesis

Cloning and Functional Characterization of a Double-Stranded RNA-Degrading Nuclease in the Tawny Crazy Ant ()

Authors: Jiaxin Lei, Yongan Tan, Fabian List, Robert Puckett, Aaron M Tarone, Edward L Vargo, Keyan Zhu-Salzman

Journal: Front Physiol

PubMed ID: 35153841

Doi: 10.3389/fphys.2022.833652

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A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells

Authors: Rong Hu, Umar Farook Shahul Hameed, Xiang Sun, Balakrishnan Shenbaga Moorthy, Wen Zhang, Philip D Jeffrey, Li Zhou, Xin Ma, Fangjin Chen, Jianfeng Pei, Pankaj K Giri, Yonggao Mou, Kunchithapadam Swaminathan, Ping Yuan

Journal: Cell Prolif

PubMed ID: 36321378

Doi: 10.1111/cpr.13350

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Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance

Authors: Hyo Jung Sim, Chanmi Cho, Ha Eun Kim, Ju Yeon Hong, Eun Kyung Song, Keun Yeong Kwon, Dong Gil Jang, Seok-Jung Kim, Hyun-Shik Lee, Changwook Lee, Taejoon Kwon, Siyoung Yang, Tae Joo Park

Journal: Sci Adv

PubMed ID: 35061535

Doi: 10.1126/sciadv.abl4222

Products & Services: Recombinant Antibody Expression

NanoBRET in C elegans illuminates functional receptor interactions in real time

Authors: Victoria Elisabeth Groß, Miron Mikhailowitsch Gershkovich, Torsten Schöneberg, Anette Kaiser, Simone Prömel

Journal: BMC Mol Cell Biol

PubMed ID: 35100990

Doi: 10.1186/s12860-022-00405-w

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Cytokines in the Immune Microenvironment Change the Glycosylation of IgG by Regulating Intracellular Glycosyltransferases

Authors: Yedi Cao, Zhijing Song, Zhendong Guo, Xue Zhao, Yan Gong, Keli Zhao, Chenxue Qu, Youyuan Huang, Yan Li, Ying Gao, Junqing Zhang, Xiaohui Guo

Journal: Front Immunol

PubMed ID: 35140700

Doi: 10.3389/fimmu.2021.724379

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

Authors: Le Thi My Le, James Robert Thompson, Phuoc Xuan Dang, Janarjan Bhandari, Amer Alam

Journal: Commun Biol

PubMed ID: 35013584

Doi: 10.1038/s42003-021-02970-w

Products & Services: Proteins, Expression, Isolation and Analysis

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Authors: Roanne Keeton, Marius B Tincho, Amkele Ngomti, Richard Baguma, Ntombi Benede, Akiko Suzuki, Khadija Khan, Sandile Cele, Mallory Bernstein, Farina Karim, Sharon V Madzorera, Thandeka Moyo-Gwete, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Daniel Mutithu, Olukayode Aremu, Cari Stek, Elsa du Bruyn, Mieke A Van Der Mescht, Zelda de Beer, Talita R de Villiers, Annie Bodenstein, Gretha van den Berg, Adriano Mendes, Amy Strydom, Marietjie Venter, Jennifer Giandhari, Yeshnee Naidoo, Sureshnee Pillay, Houriiyah Tegally, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Robert J Wilkinson, Tulio de Oliveira, Linda-Gail Bekker, Glenda Gray, Veronica Ueckermann, Theresa Rossouw, Michael T Boswell, Jinal N Bhiman, Penny L Moore, Alex Sigal, Ntobeko A B Ntusi, Wendy A Burgers, Catherine Riou

Journal: Nature

PubMed ID: 35102311

Doi: 10.1038/s41586-022-04460-3

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Engineered human antibodies for the opsonization and killing of

Authors: Xinhai Chen, Olaf Schneewind, Dominique Missiakas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35058363

Doi: 10.1073/pnas.2114478119

Products & Services: Proteins, Expression, Isolation and Analysis

Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance

Authors: Anil Kumar, Kumaran Sundaram, Yun Teng, Jingyao Mu, Mukesh K Sriwastva, Lifeng Zhang, Joshua L Hood, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Huang-Ge Zhang

Journal: Theranostics

PubMed ID: 35154496

Doi: 10.7150/thno.62514

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The Predictive Efficacy of Serum Exosomal microRNA-122 and microRNA-148a for Hepatocellular Carcinoma Based on Smart Healthcare

Authors: Peng Deng, Mi Li, Yuni Wu

Journal: J Healthc Eng

PubMed ID: 35028121

Doi: 10.1155/2022/5914541

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miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages

Authors: Ying Huang, Daomin Lu, Wukai Ma, Jun Liu, Qiaoyi Ning, Fang Tang, Long Li

Journal: Mol Immunol

PubMed ID: 35042119

Doi: 10.1016/j.molimm.2022.01.002

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Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells

Authors: Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J Moon, Max S Wicha, Bashir Kaspo, Joel Whitfield, Alfred E Chang, Qiao Li

Journal: Cancer Immunol Immunother

PubMed ID: 35098344

Doi: 10.1007/s00262-021-03129-6

Products & Services: Recombinant Proteins

An Active Peptide-Based Packaging System to Improve the Freshness and Safety of Fish Products: A Case Study

Authors: Rosa Luisa Ambrosio, Marta Gogliettino, Bruna Agrillo, Yolande T R Proroga, Marco Balestrieri, Lorena Gratino, Daniela Cristiano, Gianna Palmieri, Aniello Anastasio

Journal: Foods

PubMed ID: 35159493

Doi: 10.3390/foods11030338

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Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

Authors: Jinliang Wang, Jie Luo, Zhiyuan Wen, Xinxin Wang, Lei Shuai, Gongxun Zhong, Chong Wang, Ziruo Sun, Weiye Chen, Jinying Ge, Renqiang Liu, Xijun Wang, Zhigao Bu

Journal: MBio

PubMed ID: 35012335

Doi: 10.1128/mbio.02443-21

Products & Services: Proteins, Expression, Isolation and Analysis

Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

Authors: Hanna Klingel, Maike Lauen, Alexander Krüttgen, Matthias Imöhl, Michael Kleines

Journal: Clin Exp Vaccine Res

PubMed ID: 35223673

Doi: 10.7774/cevr.2022.11.1.121

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Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells

Authors: Xiaohong Zhang, Stephen H Wright

Journal: Int J Mol Sci

PubMed ID: 35163393

Doi: 10.3390/ijms23031472

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Solid-Phase Extraction Approaches for Improving Oligosaccharide and Small Peptide Identification with Liquid Chromatography-High-Resolution Mass Spectrometry: A Case Study on Proteolyzed Almond Extract

Authors: Yu-Ping Huang, Randall C Robinson, Fernanda Furlan Goncalves Dias, Juliana Maria Leite Nobrega de Moura Bell, Daniela Barile

Journal: Foods

PubMed ID: 35159490

Doi: 10.3390/foods11030340

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Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults

Authors: Juandy Jo, Astia Sanjaya, Reinhard Pinontoan, Maroloan Aruan, Rury Mega Wahyuni, Venansi Viktaria

Journal: Clin Exp Vaccine Res

PubMed ID: 35223672

Doi: 10.7774/cevr.2022.11.1.116

Products & Services: Proteins, Expression, Isolation and Analysis

RBP4 regulates androgen receptor expression and steroid synthesis in Sertoli cells from Bactrian camels

Authors: Qi Wang, Quanwei Zhang, Yina Li, Xingxu Zhao, Yong Zhang

Journal: Reprod Domest Anim

PubMed ID: 35014100

Doi: 10.1111/rda.14081

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Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours

Authors: Xiaoyu Yu, Ying Bai, Bing Han, Minzi Ju, Tianci Tang, Ling Shen, Mingyue Li, Li Yang, Zhao Zhang, Guoku Hu, Jie Chao, Yuan Zhang, Honghong Yao

Journal: J Extracell Vesicles

PubMed ID: 35029057

Doi: 10.1002/jev2.12185

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Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours

Authors: Xiaoyu Yu, Ying Bai, Bing Han, Minzi Ju, Tianci Tang, Ling Shen, Mingyue Li, Li Yang, Zhao Zhang, Guoku Hu, Jie Chao, Yuan Zhang, Honghong Yao

Journal: J Extracell Vesicles

PubMed ID: 35029057

Doi: 10.1002/jev2.12185

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miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7

Authors: Xibao Shi, Yuanhao Yang, Xiaozhuan Zhang, Xiaobo Chang, Jing Chen, Chao Wang, Aiping Wang, Jianhua Wang, Jianru Qin, Xianlong Ye, Wei Jin, Gaiping Zhang

Journal: Viruses

PubMed ID: 35062330

Doi: 10.3390/v14010126

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Safety and Immunogenicity of the Third Booster Dose with Inactivated, Viral Vector, and mRNA COVID-19 Vaccines in Fully Immunized Healthy Adults with Inactivated Vaccine

Authors: Sitthichai Kanokudom, Suvichada Assawakosri, Nungruthai Suntronwong, Chompoonut Auphimai, Pornjarim Nilyanimit, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Ritthideach Yorsaeng, Donchida Srimuan, Thaksaporn Thatsanatorn, Sirapa Klinfueng, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Sittisak Honsawek, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 35062747

Doi: 10.3390/vaccines10010086

Anticancer Vaccination with Immunogenic Micelles That Capture and Release Pristine CD8 T-Cell Epitopes and Adjuvants

Authors: He Ren, Jiexin Li, Gengqi Liu, Yaping Sun, Xingyue Yang, Zhen Jiang, Jingyu Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34986639

Doi: 10.1021/acsami.1c18117

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Identification and characterization of natural PR-1 protein as major allergen from Humulus japonicus pollen

Authors: Ye Wang, Ling-Xiao Tan, Zhi-Qiang Xu, Yong-Xin Jiao, Dan-Xuan Zhu, Yong-Shi Yang, Ji-Fu Wei, Jin-Lyu Sun, Man Tian

Journal: Mol Immunol

PubMed ID: 36525884

Doi: 10.1016/j.molimm.2022.11.023

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Surveillance of emerging infectious diseases for biosecurity

Authors: Rongzhang Hao, Yuqi Liu, Wanzhu Shen, Rongtao Zhao, Bo Jiang, Hongbin Song, Muyang Yan, Hui Ma

Journal: Sci China Life Sci

PubMed ID: 35287183

Doi: 10.1007/s11427-021-2071-x

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Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2

Authors: Bo Hou, Yu-Min Zhang, Han-Yi Liao, Li-Feng Fu, De-Dong Li, Xin Zhao, Jian-Xun Qi, Wei Yang, Geng-Fu Xiao, Lian Yang, Zheng-Yu Zuo, Lin Wang, Xiang-Lei Zhang, Fang Bai, Liu Yang, George F Gao, Hao Song, Jiang-Miao Hu, Wei-Juan Shang, Jun Zhou

Journal: J Nat Prod

PubMed ID: 35084181

Doi: 10.1021/acs.jnatprod.1c00805

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Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants

Authors: Taichi Kuramochi, Siok Wan Gan, Adrian W S Ho, Bei Wang, Nagisa Kageji, Takeru Nambu, Sayaka Iida, Momoko Okuda-Miura, Wei Shan Chia, Chiew Ying Yeo, Dan Chen, Wen-Hsin Lee, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Cheng-I Wang, Tomoyuki Igawa, Hideaki Shimada

Journal: MAbs

PubMed ID: 35293276

Doi: 10.1080/19420862.2022.2040350

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Activation of the plant mevalonate pathway by extracellular ATP

Authors: Sung-Hwan Cho, Katalin Tóth, Daewon Kim, Phuc H Vo, Chung-Ho Lin, Pubudu P Handakumbura, Albert Rivas Ubach, Sterling Evans, Ljiljana Paša-Tolić, Gary Stacey

Journal: Nat Commun

PubMed ID: 35064110

Doi: 10.1038/s41467-022-28150-w

Products & Services: Proteins, Expression, Isolation and Analysis

Recognition and Chaperoning by Pex19, Followed by Trafficking and Membrane Insertion of the Peroxisome Proliferation Protein, Pex11

Authors: Katarzyna M Zientara-Rytter, Shanmuga S Mahalingam, Jean-Claude Farré, Krypton Carolino, Suresh Subramani

Journal: Cells

PubMed ID: 35011719

Doi: 10.3390/cells11010157

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Objective to identify and verify the regulatory mechanism of DTNBP1 as a prognostic marker for hepatocellular carcinoma

Authors: Xianyi Cheng, Dezhi Li, Tiangyang Qi, Jia Sun, Tao Zhou, Wei V Zheng

Journal: Sci Rep

PubMed ID: 34997064

Doi: 10.1038/s41598-021-04055-4

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CRISPR guides induce gene silencing in plants in the absence of Cas

Authors: Veerendra Kumar Sharma, Sandeep Marla, Wenguang Zheng, Divya Mishra, Jun Huang, Wei Zhang, Geoffrey Preston Morris, David Edward Cook

Journal: Genome Biol

PubMed ID: 34980227

Doi: 10.1186/s13059-021-02586-7

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De Novo Transcriptome of (Cactaceae) under In Vitro Conditions and Identification of Glyoxalase Genes

Authors: Carolina Enríquez-González, Cristina Garcidueñas-Piña, Osvaldo Adrián Castellanos-Hernández, Sergio Enríquez-Aranda, Abraham Loera-Muro, Gilberto Ocampo, Eugenio Pérez-Molphe Balch, José Francisco Morales-Domínguez

Journal: Plants (Basel)

PubMed ID: 35161380

Doi: 10.3390/plants11030399

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Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

Authors: Wei Shi, Lingshu Wang, Tongqing Zhou, Mallika Sastry, Eun Sung Yang, Yi Zhang, Man Chen, Xuejun Chen, Misook Choe, Adrian Creanga, Kwan Leung, Adam S Olia, Amarendra Pegu, Reda Rawi, Chen-Hsiang Shen, Erik-Stephane D Stancofski, Chloe Adrienna Talana, I-Ting Teng, Shuishu Wang, Kizzmekia S Corbett, Yaroslav Tsybovsky, John R Mascola, Peter D Kwong

Journal: biorxiv

PubMed ID: 35118472

Doi: 10.1101/2022.01.25.477770

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Rapid sequence evolution is associated with genetic incompatibilities in the plastid Clp complex

Authors: Salah E Abdel-Ghany, Lisa M LaManna, Haleakala T Harroun, Pal Maliga, Daniel B Sloan

Journal: Plant Mol Biol

PubMed ID: 35039977

Doi: 10.1007/s11103-022-01241-4

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Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

Authors: Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C Baños, Jack Rivers-Auty, Pablo Pelegrín

Journal: BMC Biol

PubMed ID: 34996441

Doi: 10.1186/s12915-021-01220-z

Products & Services: Mammalian Expression

A Palette of Fluorescent A42 Peptides Labelled at a Range of Surface-Exposed Sites

Authors: Dev Thacker, Mara Bless, Mohammad Barghouth, Enming Zhang, Sara Linse

Journal: Int J Mol Sci

PubMed ID: 35163577

Doi: 10.3390/ijms23031655

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USF1 Transcriptionally Regulates UGT1A3 and Promotes Lung Adenocarcinoma Progression by Regulating Neurotrophin Signaling Pathway

Authors: Yu Wang, Yun-Xia Zhao, Xiang-Wei Zhang, Yuan-Zhu Jiang, Wei Ma, Lin Zhang, Wei Dong

Journal: Front Mol Biosci

PubMed ID: 35155573

Doi: 10.3389/fmolb.2022.758968

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Ion currents through Kir potassium channels are gated by anionic lipids

Authors: Ruitao Jin, Sitong He, Katrina A Black, Oliver B Clarke, Di Wu, Jani R Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M Colman, Carol V Robinson, Derek Laver, Brian J Smith, Jacqueline M Gulbis

Journal: Nat Commun

PubMed ID: 35079013

Doi: 10.1038/s41467-022-28148-4

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Covalent coupling of Spike's receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2

Authors:

Journal: Sci Rep

PubMed ID: 35027583

Doi: 10.1038/s41598-021-03675-0

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Cardiac troponin T and autoimmunity in skeletal muscle aging

Authors: Tan Zhang, Xin Feng, Juan Dong, Zherong Xu, Bo Feng, Karen M Haas, Peggy M Cawthon, Kristen M Beavers, Barbara Nicklas, Stephen Kritchevsky

Journal: Geroscience

PubMed ID: 35034279

Doi: 10.1007/s11357-022-00513-7

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Fifty Shades of E: Innate Immune Evasion by the Viral Endonucleases of All Pestivirus Species

Authors: Elena de Martin, Matthias Schweizer

Journal: Viruses

PubMed ID: 35215858

Doi: 10.3390/v14020265

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DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3

Authors: Feng Hu, Ki On Fong, May Pui Lai Cheung, Jessica Aijia Liu, Rui Liang, Tsz Wai Li, Rakesh Sharma, Philip Pun-Ching Ip, Xintao Yang, Martin Cheung

Journal: Adv Sci (Weinh)

PubMed ID: 35088579

Doi: 10.1002/advs.202105226

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Elucidating the 3D Structure of a Surface Membrane Antigen from as a Serodiagnostic Biomarker of Chagas Disease

Authors: Flavio Di Pisa, Stefano De Benedetti, Enrico Mario Alessandro Fassi, Mauro Bombaci, Renata Grifantini, Angelo Musicò, Roberto Frigerio, Angela Pontillo, Cinzia Rigo, Sandra Abelli, Romualdo Grande, Nadia Zanchetta, Davide Mileto, Alessandro Mancon, Alberto Rizzo, Alessandro Gori, Marina Cretich, Giorgio Colombo, Martino Bolognesi, Louise Jane Gourlay

Journal: Vaccines (Basel)

PubMed ID: 35062732

Doi: 10.3390/vaccines10010071

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Mechanism of MyD88S mediated signal termination

Authors: Katarzyna Pustelny, Katarzyna Kuska, Andrzej Gorecki, Bogdan Musielak, Ewelina Dobosz, Benedykt Wladyka, Joanna Koziel, Anna Czarna, Tad Holak, Grzegorz Dubin

Journal: Cell Commun Signal

PubMed ID: 35057808

Doi: 10.1186/s12964-021-00811-1

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Antigenic and immunogenic properties of recombinant proteins consisting of two immunodominant African swine fever virus proteins fused with bacterial lipoprotein OprI

Authors: Guanglei Zhang, Wei Liu, Zhan Gao, Yanyan Chang, Sicheng Yang, Qian Peng, Sudan Ge, Bijing Kang, Junjun Shao, Huiyun Chang

Journal: Virol J

PubMed ID: 35062983

Doi: 10.1186/s12985-022-01747-9

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RIPPA: Identification of MHC-II Binding Peptides from Antigen Using a Yeast Display-Based Approach

Authors: Rongzeng Liu, Wei Jiang, Ying Li, Elizabeth D Mellins

Journal: Curr Protoc

PubMed ID: 35041265

Doi: 10.1002/cpz1.350

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Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein

Authors: Yunwen Zhang, Zhengrong Yang, Mingyuan Tang, Hao Li, Tian Tang, Guilian Li, Yifan Zhong, Xiaomin Zhang, Xiaohui Wang, Chuan Wang

Journal: Front Immunol

PubMed ID: 35154095

Doi: 10.3389/fimmu.2022.752622

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Severe Natural Outbreak of in Gilthead Seabream Produces Leukocyte Mobilization and Innate Immunity at the Gill Tissue

Authors: Laura Cervera, Carmen González-Fernández, Marta Arizcun, Alberto Cuesta, Elena Chaves-Pozo

Journal: Int J Mol Sci

PubMed ID: 35055122

Doi: 10.3390/ijms23020937

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Isoforms of the neuropeptide myosuppressin differentially modulate the cardiac neuromuscular system of the American lobster,

Authors: Emily R Oleisky, Meredith E Stanhope, J Joe Hull, Patsy S Dickinson

Journal: J Neurophysiol

PubMed ID: 35044860

Doi: 10.1152/jn.00338.2021

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The ectomycorrhizal basidiomycete Laccaria bicolor releases a GH28 polygalacturonase that plays a key role in symbiosis establishment

Authors: Feng Zhang, Aurore Labourel, Mireille Haon, Minna Kemppainen, Emilie Da Silva Machado, Nicolas Brouilly, Claire Veneault-Fourrey, Annegret Kohler, Marie-Noëlle Rosso, Alejandro Pardo, Bernard Henrissat, Jean-Guy Berrin, Francis Martin

Journal: New Phytol

PubMed ID: 34942023

Doi: 10.1111/nph.17940

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Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Authors: Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J M Huijbers, Danielle R J Verboogen, Matthias Reichel, Victor L Thijssen, Arjan W Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson

Journal: Cancer Immunol Immunother

PubMed ID: 35018481

Doi: 10.1007/s00262-021-03139-4

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Experimental Periodontitis Deteriorated Atherosclerosis Associated With Trimethylamine N-Oxide Metabolism in Mice

Authors: Lingling Xiao, Lingyan Huang, Xin Zhou, Dan Zhao, Yan Wang, Haiyan Min, Shiyu Song, Weibin Sun, Qian Gao, Qingang Hu, Sijing Xie

Journal: Front Cell Infect Microbiol

PubMed ID: 35118014

Doi: 10.3389/fcimb.2021.820535

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The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities

Authors: Raffaele Iennaco, Giulio Formenti, Camilla Trovesi, Riccardo Lorenzo Rossi, Chiara Zuccato, Tiziana Lischetti, Vittoria Dickinson Bocchi, Andrea Scolz, Cristina Martínez-Labarga, Olga Rickards, Michela Pacifico, Angelica Crottini, Anders Pape Møller, Richard Zhenghuan Chen, Thomas Francis Vogt, Giulio Pavesi, David Stephen Horner, Nicola Saino, Elena Cattaneo

Journal: Cell Death Differ

PubMed ID: 34974533

Doi: 10.1038/s41418-021-00914-9

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Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids

Authors: Icaro Putinhon Caruso, Vitor Dos Santos Almeida, Mariana Juliani do Amaral, Guilherme Caldas de Andrade, Gabriela Rocha de Araújo, Talita Stelling de Araújo, Jéssica Moreira de Azevedo, Glauce Moreno Barbosa, Leonardo Bartkevihi, Peter Reis Bezerra, Katia Maria Dos Santos Cabral, Isabella Otênio de Lourenço, Clara L F Malizia-Motta, Aline de Luna Marques, Nathane Cunha Mebus-Antunes, Thais Cristtina Neves-Martins, Jéssica Maróstica de Sá, Karoline Sanches, Marcos Caique Santana-Silva, Ariana Azevedo Vasconcelos, Marcius da Silva Almeida, Gisele Cardoso de Amorim, Cristiane Dinis Anobom, Andrea T Da Poian, Francisco Gomes-Neto, Anderson S Pinheiro, Fabio C L Almeida

Journal: Int J Biol Macromol

PubMed ID: 35077748

Doi: 10.1016/j.ijbiomac.2022.01.121

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Improving one-step scarless genome editing in by combining co-CRISPR selection with sgRNA target site masking

Authors: Katharina J Götze, Achmed Mrestani, Paula Beckmann, Knut Krohn, Diana Le Duc, Akhil Velluva, Mathias A Böhme, Manfred Heckmann, Rami Abou Jamra, Johannes R Lemke, Hendrik Bläker, Nicole Scholz, Dmitrij Ljaschenko, Tobias Langenhan

Journal: Biol Methods Protoc

PubMed ID: 35087953

Doi: 10.1093/biomethods/bpac003

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A murine Skint6 W168X allele contributes to autoimmune disease in a transgenic model

Authors: Jiyu Ju, Hui Wang, Meng Lian, Yatao Bao, Yanyan Zhang, Zhiwei Xu

Journal: Lupus

PubMed ID: 35045734

Doi: 10.1177/09612033221074544

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A Peptide from Budding Yeast GAPDH Serves as a Promising Antifungal against Cryptococcus neoformans

Authors: Yang Zhang , Liyan Zhou , Yan Liu , Xi Zhao , Xianqiang Lian , Jie Zhang, De Zhao , Yujuan Wang , Jin Zhong , Junfeng Wang , Hongli Wang , Linqi Wang , Yu V Fu

Journal: Microbiol Spectr

PubMed ID: 35019693

Doi: 10.1128/spectrum.00826-21

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Rapid and Specific Detection of Active SARS-CoV-2 With CRISPR/Cas12a

Authors: Xinyi Liu , Yanhua Li , Xin Wang , Yifan Song , Lina Wu , Benyuan Yu , Xiaodong Ma , Peixiang Ma, Ming Liu , Xingxu Huang , Xinjie Wang

Journal: Front Microbiol

PubMed ID: 35154046

Doi: 10.3389/fmicb.2021.820698

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An effective cytokine combination for ex vivo expansion of porcine muscle stem cells

Authors: Qingzi Lei, Mei Li, Guocheng Du, Jingwen Zhou, Xin Guan

Journal: Food Bioscience

Doi: 10.1016/j.fbio.2022.101571

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Long-Term High-Fat Diet Consumption Depletes Glial Cells and Tyrosine Hydroxylase-Containing Neurons in the Brain of Middle-Aged Rats

Authors: Mei-Chuan Chou, Hsiang-Chun Lee, Yen-Chin Liu, Patrick Szu-Ying Yen, Ching-Kuan Liu, Chu-Huang Chen, Tzu-Han Hsieh, Shiou-Lan Chen

Journal: Cells

PubMed ID: 35053411

Doi: 10.3390/cells11020295

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Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation

Authors: Ruth Galindo, Elena Sánchez-López, María José Gómara, Marta Espina, Miren Ettcheto, Amanda Cano, Isabel Haro, Antoni Camins, María Luisa García

Journal: Pharmaceutics

PubMed ID: 35214019

Doi: 10.3390/pharmaceutics14020285

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Minc03328 effector gene downregulation severely affects Meloidogyne incognita parasitism in transgenic Arabidopsis thaliana

Authors: Valdeir Junio Vaz Moreira, Isabela Tristan Lourenço-Tessutti, Marcos Fernando Basso, Maria Eugênia Lisei-de-Sa, Carolina Vianna Morgante, Bruno Paes-de-Melo, Fabrício Barbosa Monteiro Arraes, Diogo Martins-de-Sa, Maria Cristina Mattar Silva, Janice de Almeida Engler, Maria Fatima Grossi-de-Sa

Journal: Planta

PubMed ID: 35050413

Doi: 10.1007/s00425-022-03823-4

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The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a

Authors: Luiza Mamigonian Bessa, Serafima Guseva, Aldo R Camacho-Zarco, Nicola Salvi, Damien Maurin, Laura Mariño Perez, Maiia Botova, Anas Malki, Max Nanao, Malene Ringkjøbing Jensen, Rob W H Ruigrok, Martin Blackledge

Journal: Sci Adv

PubMed ID: 35044811

Doi: 10.1126/sciadv.abm4034

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Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Authors: Sunesh Sethumadhavan, Marie Barth, Robbert M Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé

Journal: Sci Rep

PubMed ID: 35087068

Doi: 10.1038/s41598-022-05000-9

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Genome-wide characterization of Histone gene family and expression profiling during microspore development in radish (Raphanus sativus L)

Authors: Qijiao Wang, Lianxue Fan, Xiaojun Su, Jiali Ying, Liang Xu, Cui Li, Yan Wang, Liwang Liu

Journal: Gene

PubMed ID: 34990794

Doi: 10.1016/j.gene.2021.146180

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Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening

Authors: Meghan J O'Melia, Adriana Mulero-Russe, Jihoon Kim, Alyssa Pybus, Deborah DeRyckere, Levi Wood, Douglas K Graham, Edward Botchwey, Andrés J García, Susan N Thomas

Journal: Adv Mater

PubMed ID: 34989049

Doi: 10.1002/adma.202108084

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Single-conformation spectroscopy of cold, protonated PG-containing peptides: switching β-turn types and formation of a sequential type II/II' double β-turn

Authors: John T Lawler, Christopher P Harrilal, Andrew F DeBlase, Edwin L Sibert, Scott A McLuckey, Timothy S Zwier

Journal: Phys Chem Chem Phys

PubMed ID: 35019911

Doi: 10.1039/d1cp04852j

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GRIM-19 is a target of mycobacterial Zn metalloprotease 1 and indispensable for NLRP3 inflammasome activation

Authors: Tomomi Kurane, Tetsuro Matsunaga, Tomoaki Ida, Kazuko Sawada, Akira Nishimura, Masayuki Fukui, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Sohkichi Matsumoto, Takaaki Akaike, Goro Matsuzaki, Giichi Takaesu

Journal: FASEB J

PubMed ID: 34907600

Doi: 10.1096/fj.202101074RR

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Efficacy of Convalescent Plasma to Treat Mild to Moderate COVID-19 in Kidney Transplant Patients: A Propensity Score Matching Analysis

Authors: Marina Pontello Cristelli, Dante Mário Langhi Junior, Laila Almeida Viana, Luis Gustavo Modelli de Andrade, Suelen Bianca Stopa Martins, Yasmim Cardoso Dreige, José Orlando Bordim, Helio Tedesco-Silva, José Medina-Pestana

Journal: Transplantation

PubMed ID: 34581314

Doi: 10.1097/TP.0000000000003962

Nucleic acid biomarkers to assess graft injury after liver transplantation

Authors: Elissa Bardhi, Jennifer McDaniels, Thomas Rousselle, Daniel G Maluf, Valeria R Mas

Journal: JHEP Rep

PubMed ID: 35243279

Doi: 10.1016/j.jhepr.2022.100439

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