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E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2

Authors: Stephanie N Langel, Francine L Kelly, David M Brass, Andrew E Nagler, Dylan Carmack, Joshua J Tu, Tatianna Travieso, Ria Goswami, Sallie R Permar, Maria Blasi, Scott M Palmer

Journal: Cell Death Discov

PubMed ID: 35169120

Doi: 10.1038/s41420-022-00855-3

Products & Services: Plasmid DNA Preparation

Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana

Authors: Xiaodong Su, Duanfang Cao, Xiaowei Pan, Lifang Shi, Zhenfeng Liu, Luca Dall'Osto, Roberto Bassi, Xinzheng Zhang, Mei Li

Journal: Mol Plant

PubMed ID: 35123031

Doi: 10.1016/j.molp.2022.01.020

Products & Services: Gene Synthesis

Rapid, High Throughput, Automated Detection Of SARS-Cov-2 Neutralizing Antibodies Against Native-Like Vaccine And Delta Variant Spike Trimers

Authors: Narayanaiah Cheedarla, Hans Verkerke, Sindhu Potlapalli, Kaleb McLendon, Anamika Patel, Filipp Frank, Gregory Damhorst, Huixia Wu, William O'Sick, Daniel Graciaa, Fuad Hudaib, David Alter, Jeannette Bryksin, Eric Ortlund, Jeannette Guarner, Sara Auld, Sarita Shah, Wilbur Lam, Dawn Mattoon, Joseph Johnson, David Wilson, Madhav Dhodapkar, Sean Stowell, Andrew Neish, John Roback

Journal: Res Sq

PubMed ID: 35194599

Doi: 10.21203/rs.3.rs-1322411/v1

Products & Services: Mammalian Expression

Mesophyll conductance is unaffected by expression of Arabidopsis PIP1 aquaporins in the plasmalemma of Nicotiana

Authors: Victoria C Clarke, Baxter Massey, Aleu Mani George, John R Evans, Susanne von Caemmerer, Michael Groszmann

Journal: J Exp Bot

PubMed ID: 35184158

Doi: 10.1093/jxb/erac065

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Engineering of thick human functional myocardium via static stretching and electrical stimulation

Authors: Danielle Pretorius, Asher M Kahn-Krell, Wesley C LaBarge, Xi Lou, Jianyi Zhang

Journal: iScience

PubMed ID: 35243219

Doi: 10.1016/j.isci.2022.103824

Products & Services: Proteins, Expression, Isolation and Analysis

Construction and characterization of two SARS-CoV-2 minigenome replicon systems

Authors: Hu Zhang, Douglas K Fischer, Masahiro Shuda, Patrick S Moore, Shou-Jiang Gao, Zandrea Ambrose, Haitao Guo

Journal: J Med Virol

PubMed ID: 35137972

Doi: 10.1002/jmv.27650

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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Authors: Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen

Journal: Nucleic Acids Res

PubMed ID: 35212371

Doi: 10.1093/nar/gkac133

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Expression and characterization of a novel lytic polysaccharide monooxygenase, PdLPMO9A, from the edible fungus Pleurotus djamor and its synergistic interactions with cellulase in corn straw biomass saccharification

Authors: Yanli Li, Tongbing Li, Juntong Guo, Gang Wang, Guang Chen

Journal: Bioresour Technol

PubMed ID: 35121098

Doi: 10.1016/j.biortech.2022.126792

Products & Services: Recombinant Antibody Expression

The function of glucose metabolism in embryonic diapause of annual killifish

Authors: Xiaowen Gao, Tianyi Cai, Yongtong Lin, Rui Zhu, Wenxin Hao, Shuming Guo, Guangfu Hu

Journal: Comp Biochem Physiol Part D Genomics Proteomics

PubMed ID: 35149343

Doi: 10.1016/j.cbd.2022.100965

Products & Services: Recombinant Proteins

Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1

Authors: Anastasia Zekeridou, Binxia Yang, Vanda A Lennon, Yong Guo, Liang Wu, Claudia F Lucchinetti, Andrew McKeon, Sean J Pittock, Eoin P Flanagan

Journal: Ann Neurol

PubMed ID: 35150165

Doi: 10.1002/ana.26320

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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability

Authors: Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian

Journal: Bioengineered

PubMed ID: 35081868

Doi: 10.1080/21655979.2021.2024962

Products & Services: ORF cDNA Clones/MolecularCloud

Characterization, mRNA expression profile, subcellular distribution and association analysis with piglet diarrhea of porcine matrix metallopeptidase 7 (pMMP7)

Authors: Buyue Niu, Lu Liu, Zhihua Chen, Mingxing Kou, Xiuqin Yang, Yuan Sun, Shengwei Di, Xibiao Wang, Jiancheng Cai, Dongchun Guo

Journal: Gene

PubMed ID: 35182673

Doi: 10.1016/j.gene.2022.146319

Products & Services: Protein Tools

Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies

Authors: S Saellström, H Sharif, K K Jagarlamudi, H Rönnberg, L Wang, S Eriksson

Journal: Res Vet Sci

PubMed ID: 35245727

Doi: 10.1016/j.rvsc.2022.02.019

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Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Authors: Rhye-Samuel Kanassatega, Thomas A Bunch, Victoria C Lepak, Christopher Wang, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 35227736

Doi: 10.1016/j.yjmcc.2022.02.005

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Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

Authors: Mushtaq A Ansari, Ahmed Nadeem, Musaad A Alshammari, Sabry M Attia, Saleh A Bakheet, Mohammad R Khan, Thamer H Albekairi, Abdullah F Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A Al-Mazroua, Sheikh F Ahmad

Journal: Exp Neurol

PubMed ID: 35122866

Doi: 10.1016/j.expneurol.2022.113997

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Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro

Authors: Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35106909

Doi: 10.1111/jcmm.17212

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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

Authors: Lifeng Qin, Xin Liu, Li'na Lan, Xiaoping Lv

Journal: Int J Gen Med

PubMed ID: 35173468

Doi: 10.2147/IJGM.S343968

Products & Services: GenParts™ DNA Fragments

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Authors: Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan

Journal: Hum Vaccin Immunother

PubMed ID: 35209809

Doi: 10.1080/21645515.2022.2029111

A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy

Authors: Yue Wang, Yaxian Mei, Zhenghong Ao, Yuanzhi Chen, Yichao Jiang, Xiaoqing Chen, Ruoyao Qi, Baorong Fu, Jixian Tang, Mujin Fang, Min You, Tianying Zhang, Quan Yuan, Wenxin Luo, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 35183645

Doi: 10.1016/j.antiviral.2022.105265

Products & Services: Proteins, Expression, Isolation and Analysis

Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

Products & Services: PCR and Cloning

Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening

Authors: Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C E Tosatto

Journal: Cancers (Basel)

PubMed ID: 35205757

Doi: 10.3390/cancers14041009

Products & Services: Plasmid DNA Preparation

Melanocortin receptor agonists suppress experimental autoimmune uveitis

Authors: Tat Fong Ng, Kaleb Dawit, Andrew W Taylor

Journal: Exp Eye Res

PubMed ID: 35196505

Doi: 10.1016/j.exer.2022.108986

Products & Services: Mammalian Expression

Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking

Authors: Constancio Gonzalez-Obeso, Fredrik G Backlund, David L Kaplan

Journal: Biomacromolecules

PubMed ID: 35113522

Doi: 10.1021/acs.biomac.1c01192

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Photodynamic Activation of the Cholecystokinin 1 Receptor with Tagged Genetically Encoded Protein Photosensitizers: Optimizing the Tagging Patterns

Authors: Yuan Li, Zong Jie Cui

Journal: Photochem Photobiol

PubMed ID: 35211987

Doi: 10.1111/php.13611

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Photodynamic Activation of the Cholecystokinin 1 Receptor with Tagged Genetically Encoded Protein Photosensitizers: Optimizing the Tagging Patterns

Authors: Yuan Li, Zong Jie Cui

Journal: Photochem Photobiol

PubMed ID: 35211987

Doi: 10.1111/php.13611

Products & Services: Plasmid DNA Preparation

Fitness benefits play a vital role in the retention of the Pi-ta susceptible alleles

Authors: Jia Liu, Suobing Zhang, Pengfei Xie, Long Wang, Jia-Yu Xue, Yanmei Zhang, Ruisen Lu, Yueyu Hang, Yue Wang, Xiaoqin Sun

Journal: Genetics

PubMed ID: 35143673

Doi: 10.1093/genetics/iyac019

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: Emerg Infect Dis

PubMed ID: 35076009

Doi: 10.3201/eid2802.211725

Products & Services: Recombinant Proteins

Long noncoding RNASEH1-AS1 exacerbates the progression of non-small cell lung cancer by acting as a ceRNA to regulate microRNA-516a-5p/FOXK1 and thereby activating the Wnt/β-catenin signaling pathway

Authors: Chan Zhang, Jian Huang, Ke Lou, Hui Ouyang

Journal: Cancer Med

PubMed ID: 35166053

Doi: 10.1002/cam4.4509

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Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins

Authors: Frederik G Tidemand, Sara Blemmer, Nicolai T Johansen, Lise Arleth, Martin Cramer Pedersen

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35182589

Doi: 10.1016/j.bbamem.2022.183884

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LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis

Authors: Yang Li, Yuanyuan Lv, Jiangya Wang, Xiuli Zhu, Jian Chen, Wenting Zhang, Chuan Wang, Lian Jiang

Journal: Arch Med Res

PubMed ID: 35164979

Doi: 10.1016/j.arcmed.2022.01.004

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African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-B Signaling Pathway

Authors: Qi Wang , Luyu Zhou , Jiang Wang , Dan Su , Dahua Li , Yongkun Du , Guoyu Yang , Gaiping Zhang , Beibei Chu

Journal: Viruses

PubMed ID: 35215987

Doi: 10.3390/v14020394

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Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

Authors: Cong Sun , Yin-Feng Kang , Yuan-Tao Liu , Xiang-Wei Kong , Hui-Qin Xu , Dan Xiong , Chu Xie , Yi-Hao Liu , Sui Peng , Guo-Kai Feng , Zheng Liu , Mu-Sheng Zeng

Journal: Signal Transduct Target Ther

PubMed ID: 35136040

Doi: 10.1038/s41392-022-00910-6

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

Heterologous Synthesis and Secretion of Ricinoleic Acid in Starmerella bombicola with Sophorolipid as an Intermediate

Authors: Mohor Chatterjee , Jay B Patel , Spencer T Stober, Xiaozhou Zhang

Journal: ACS Synth Biol

PubMed ID: 35157794

Doi: 10.1021/acssynbio.1c00457

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Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing

Authors: Guoxu Song , Fei Zhang , Chunhong Tian , Xing Gao, Xiaoxiao Zhu, Dongdong Fan, Yong Tian

Journal: Nucleic Acids Res

PubMed ID: 35188577

Doi: doi.org/10.1093/nar/gkac099

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MPLA-Adjuvanted Liposomes Encapsulating S-Trimer or RBD or S1, but Not S-ECD, Elicit Robust Neutralization Against SARS-CoV-2 and Variants of Concern

Authors: Jian Wang, Xu-Guang Yin, Yu Wen, Jie Lu, Ru-Yan Zhang, Shi-Hao Zhou, Chun-Miao Liao, Hua-Wei Wei, Jun Guo

Journal: J Med Chem

PubMed ID: 35108485

Doi: 10.1021/acs.jmedchem.1c02025

Products & Services: Proteins, Expression, Isolation and Analysis

Jasmonic acid biosynthetic genes TgLOX4 and TgLOX5 are involved in daughter bulb development in tulip (Tulipa gesneriana)

Authors: Qi Sun, Bei Zhang, Chaolong Yang, Weiliang Wang, Lin Xiang, Yanping Wang, Zhulong Chan

Journal: Hortic Res

PubMed ID: 35147193

Doi: 10.1093/hr/uhac006

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Role of IL-17 in Morphogenesis and Dissemination of during Murine Infection

Authors: Nuria Trevijano-Contador, Elena Roselletti, Rocío García-Rodas, Anna Vecchiarelli, Óscar Zaragoza

Journal: Microorganisms

PubMed ID: 35208830

Doi: 10.3390/microorganisms10020373

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Authors: Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B Hinkle, David Kan, Ehud Segal, Jason E Long, Tony Lima, Nicholas P D Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R Junttila, Andrey S Shaw, Mark Merchant, Matthew T Chang, Donald S Kirkpatrick, Shiva Malek

Journal: Cell Rep

PubMed ID: 35139374

Doi: 10.1016/j.celrep.2022.110351

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Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis

Authors: Dogan Can Kirman, Bhuvanasundar Renganathan, Wai Kit Chui, Ming Wei Chen, Neslihan Arife Kaya, Ruowen Ge

Journal: Cell Death Dis

PubMed ID: 35197459

Doi: 10.1038/s41419-022-04618-x

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Recombinant Mosquito Densovirus with Toxins Significantly Improves Pathogenicity against

Authors: Khadija Batool, Intikhab Alam, Peiwen Liu, Zeng Shu, Siyu Zhao, Wenqiang Yang, Xiao Jie, Jinbao Gu, Xiao-Guang Chen

Journal: Toxins (Basel)

PubMed ID: 35202174

Doi: 10.3390/toxins14020147

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Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity

Authors: Monica Mesa-Perez, Phineas T Hamilton, Alex Miranda, Nicholas Brodie, Connor O'Sullivan, Jennifer Christie, Bridget C Ryan, Robert L Chow, David Goodlett, Christopher J Nelson, Perry L Howard

Journal: Nucleic Acids Res

PubMed ID: 35104878

Doi: 10.1093/nar/gkac033

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Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection

Authors: Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Viruses

PubMed ID: 35216022

Doi: 10.3390/v14020429

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Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3

Authors: Zhonggang Hou , Chunyi Hu , Ailong Ke , Yan Zhang

Journal: Curr Protoc

PubMed ID: 35129865

Doi: 10.1002/cpz1.361

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A Necroptosis-Related Prognostic Model of Uveal Melanoma Was Constructed by Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases

Authors: Jiaheng Xie, Liang Chen, Qikai Tang, Wei Wei, Yuan Cao, Chuyan Wu, Jing Hang, Kai Zhang, Jingping Shi, Ming Wang

Journal: Front Immunol

PubMed ID: 35242144

Doi: 10.3389/fimmu.2022.847624

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Safety and immunogenicity of a live recombinant Newcastle disease virus-based COVID-19 vaccine (Patria) administered via the intramuscular or intranasal route: Interim results of a non-randomized open label phase I trial in Mexico

Authors: Samuel Ponce-de-León, Martha Torres, Luis Enrique Soto-Ramírez, Juan José Calva, Patricio Santillán-Doherty, Dora Eugenia Carranza-Salazar, Juan Manuel Carreño, Claudia Carranza, Esmeralda Juárez, Laura E Carreto-Binaghi, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Rosalía Vigueras-Moreno, Alejandro Ortiz-Stern, Yolanda López-Vidal, Alejandro E Macías, Jesús Torres-Flores, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Hisaaki Kawabata, Irene González-Domínguez, José Luis Martínez-Guevara, Weina Sun, David Sarfati-Mizrahi, Ernesto Soto-Priante, Héctor Elías Chagoya-Cortés, Constantino López-Macías, Felipa Castro-Peralta, Peter Palese, Adolfo García-Sastre, Florian Krammer, Bernardo Lozano-Dubernard

Journal: medrxiv

PubMed ID: 35169806

Doi: 10.1101/2022.02.08.22270676

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A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Authors: Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross A D Bathgate

Journal: Int J Mol Sci

PubMed ID: 35163827

Doi: 10.3390/ijms23031908

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Colicin E1 opens its hinge to plug TolC

Authors: S Jimmy Budiardjo, Jacqueline J Stevens, Anna L Calkins, Ayotunde P Ikujuni, Virangika K Wimalasena, Emre Firlar, David A Case, Julie S Biteen, Jason T Kaelber, Joanna S G Slusky

Journal: Elife

PubMed ID: 35199644

Doi: 10.7554/eLife.73297

Products & Services: Proteins, Expression, Isolation and Analysis

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Authors: Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman

Journal: Nat Commun

PubMed ID: 35136084

Doi: 10.1038/s41467-022-28424-3

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CRISPR-dCas9 based DNA detection scheme for diagnostics in resource-limited settings

Authors: Michel Bengtson, Mitasha Bharadwaj, Oskar Franch, Jaco van der Torre, Veronique Meerdink, Henk Schallig, Cees Dekker

Journal: Nanoscale

PubMed ID: 35044397

Doi: 10.1039/d1nr06557b

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An engineered bispecific human monoclonal antibody against SARS-CoV-2

Authors: Zhaohui Li, Shihua Li, Gen Zhang, Weiyu Peng, Zhen Chang, Xue Zhang, Zheng Fan, Yan Chai, Feiran Wang, Xin Zhao, Dedong Li, Rong Zhang, Zhanlong He, Weiwei Zou, Ke Xu, Wenwen Lei, Peipei Liu, Junfeng Hao, Jingjing Zhang, Litao Sun, Guizhen Wu, Shuguang Tan, George Fu Gao, Feng Gao, Yan Wu

Journal: Nat Immunol

PubMed ID: 35228696

Doi: 10.1038/s41590-022-01138-w

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Placental methylome reveals a 22q1333 brain regulatory gene locus associated with autism

Authors: Yihui Zhu, J Antonio Gomez, Benjamin I Laufer, Charles E Mordaunt, Julia S Mouat, Daniela C Soto, Megan Y Dennis, Kelly S Benke, Kelly M Bakulski, John Dou, Ria Marathe, Julia M Jianu, Logan A Williams, Orangel J Gutierrez Fugón, Cheryl K Walker, Sally Ozonoff, Jason Daniels, Luke P Grosvenor, Heather E Volk, Jason I Feinberg, M Daniele Fallin, Irva Hertz-Picciotto, Rebecca J Schmidt, Dag H Yasui, Janine M LaSalle

Journal: Genome Biol

PubMed ID: 35168652

Doi: 10.1186/s13059-022-02613-1

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Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy

Authors: Hung X Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P Landstrom, Craig Henriquez, Nenad Bursac

Journal: Nat Commun

PubMed ID: 35110560

Doi: 10.1038/s41467-022-28251-6

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Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

Authors: Zhifeng Liu, Jianlin Xu, Haili Liu, Yong Wang

Journal: Microb Biotechnol

PubMed ID: 35174640

Doi: 10.1111/1751-7915.14000

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Antibody responses to 2 doses of mRNA Covid vaccine in pediatric renal patients

Authors: Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu-Lung Lau

Journal: Kidney Int

PubMed ID: 35231464

Doi: 10.1016/j.kint.2022.01.035

Products & Services: Proteins, Expression, Isolation and Analysis

Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus

Authors: Sau Yee Tsoi, Merve Öncül, Ella Svahn, Mark Robertson, Zuzanna Bogdanowicz, Christina McClure, Gülşen Sürmeli

Journal: Elife

PubMed ID: 35188100

Doi: 10.7554/eLife.73162

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Performance evaluation of novel fluorescent-based lateral flow immunoassay (LFIA) for rapid detection and quantification of total anti-SARS-CoV-2 S-RBD binding antibodies in infected individuals

Authors: Farah M Shurrab, Nadin Younes, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Int J Infect Dis

PubMed ID: 35231609

Doi: 10.1016/j.ijid.2022.02.052

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Elucidating the acid-base mechanisms underlying otolith overgrowth in fish exposed to ocean acidification

Authors: Garfield T Kwan, Martin Tresguerres

Journal: Sci Total Environ

PubMed ID: 35143791

Doi: 10.1016/j.scitotenv.2022.153690

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Functional antibody-dependent cell mediated cytotoxicity (ADCC) responses to vaccine and circulating influenza strains following vaccination

Authors: Xuemin Chen, He-Ying Sun, Chun Yi Lee, Christina A Rostad, Jessica Trost, Rodrigo B Abreu, Michael A Carlock, Jason R Wilson, Shane Gansebom, Ted M Ross, David A Steinhauer, Evan J Anderson, Larry J Anderson

Journal: Virology

PubMed ID: 35255298

Doi: 10.1016/j.virol.2022.02.004

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High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 90

Authors: Rosa Maria Chura-Chambi, Alvaro Rossan de Brandão Prieto-da-Silva, Matheus Martins Di Lela, João Ezequiel Oliveira, Patricia Estima Antonia Abreu, Luciana Regina Meireles, Heitor Franco de Andrade Junior, Ligia Morganti

Journal: PLoS ONE

PubMed ID: 35113919

Doi: 10.1371/journal.pone.0262591

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Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: Sci Transl Med

PubMed ID: 35166573

Doi: 10.1126/scitranslmed.abn8057

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Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine

Authors: Sayoni Ray, David M Wirth, Oscar A Ortega-Rivera, Nicole F Steinmetz, Jonathan K Pokorski

Journal: Biomacromolecules

PubMed ID: 35139303

Doi: 10.1021/acs.biomac.1c01345

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Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Authors: Gail Brenda Cross, Claire M Naftalin, Jinghao Nicholas Ngiam, Natasha Bagdasarian, Chek Meng Poh, Yun Shan Goh, Wan Ni Chia, Siti Naqiah Amrun, Sai Meng Tham, Hazel Teng, Rawan Alagha, Shoban Krishna Kumar, Shaun Shi Yan Tan, Lin Fa Wang, Paul Anantharajah Tambyah, Laurent Renia, Dale Fisher, Lisa F P Ng

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease

Authors: Gapisha Karunakaran, Yidai Yang, Véronique Tremblay, Zhibin Ning, Jade Martin, Amine Belaouad, Daniel Figeys, Joseph S Brunzelle, Patrick M Giguere, Alain Stintzi, Jean-François Couture

Journal: FEBS Lett

PubMed ID: 35122247

Doi: 10.1002/1873-3468.14295

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APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Authors: Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A Hu

Journal: Biochem J

PubMed ID: 35084016

Doi: 10.1042/BCJ20210813

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Tetrahymena thermophila granule lattice protein 3 improves solubility of sexual stage malaria antigens expressed in Escherichia coli

Authors: Cengiz Akkale, Donna Marie Cassidy-Hanley, Theodore G Clark

Journal: Protein Expr Purif

PubMed ID: 35134517

Doi: 10.1016/j.pep.2022.106060

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Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis

Authors: Divya Goel, Sudhir Kumar, Gopal Krishna Joshi, Prashant Rai, Rakesh Bhatnagar

Journal: Protein Expr Purif

PubMed ID: 35114377

Doi: 10.1016/j.pep.2022.106059

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Discrepant serological findings in SARS-CoV-2 PCR negative, hospitalised patients with fever and acute respiratory symptoms during the pandemic

Journal: J Med Virol

PubMed ID: 35171507

Doi: 10.1002/jmv.27656

Immunoaffinity monoliths for multiplexed extraction of preterm birth biomarkers from human blood serum in 3D printed microfluidic devices

Authors: Haifa M Almughamsi, Makella K Howell, Samuel R Parry, Joule E Esene, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

Journal: Analyst

PubMed ID: 35103723

Doi: 10.1039/d1an01365c

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Comparison of Neutralizing Antibody Responses at 6 Months Post Vaccination with BNT162b2 and AZD1222

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Zoi Evangelakou, Maria Gavriatopoulou, Maria S Manola, Panagiotis Malandrakis, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Biomedicines

PubMed ID: 35203547

Doi: 10.3390/biomedicines10020338

The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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Calcium and integrin-binding protein 1-like interacting with an integrin α-cytoplasmic domain facilitates cellular immunity in Helicoverpa armigera

Authors: Ming-Ming Zhang, Ling-Ling Luo, Yu Liu, Gui-Jie Wang, Huan-Huan Zheng, Xu-Sheng Liu, Jia-Lin Wang

Journal: Dev Comp Immunol

PubMed ID: 35231466

Doi: 10.1016/j.dci.2022.104379

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Fitness benefits play a vital role in the retention of the Pi-ta susceptible alleles

Authors: Jia Liu, Suobing Zhang, Pengfei Xie, Long Wang, Jia-Yu Xue, Yanmei Zhang, Ruisen Lu, Yueyu Hang, Yue Wang, Xiaoqin Sun

Journal: Genetics

PubMed ID: 35143673

Doi: 10.1093/genetics/iyac019

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Circular dichroism spectroscopic assessment of structural changes upon protein thermal unfolding at contrasting pH: Comparison with molecular dynamics simulations

Authors: Ponciano García-Gutiérrez, Menandro Camarillo-Cadena, Liliana I Vera-Robles, Rafael A Zubillaga, Andrés Hernández-Arana

Journal: Spectrochim Acta A Mol Biomol Spectrosc

PubMed ID: 35245803

Doi: 10.1016/j.saa.2022.121039

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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Authors: Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries

Journal: Front Mol Biosci

PubMed ID: 35211509

Doi: 10.3389/fmolb.2022.811116

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Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells

Authors: Weijiang Wu, Zhe Wang, Zhijian Zhang, Wenjing Yang, Xin Fan, Jili Xu, Zhiqiang Huang, Qixiang Shao

Journal: Cell Tissue Bank

PubMed ID: 35147838

Doi: 10.1007/s10561-022-09994-4

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Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells

Authors: Weijiang Wu, Zhe Wang, Zhijian Zhang, Wenjing Yang, Xin Fan, Jili Xu, Zhiqiang Huang, Qixiang Shao

Journal: Cell Tissue Bank

PubMed ID: 35147838

Doi: 10.1007/s10561-022-09994-4

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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines

Authors: Noëmi Johanna Roos, Riccardo Vincenzo Mancuso, Gerda Mawududzi Sanvee, Jamal Bouitbir, Stephan Krähenbühl

Journal: Food Chem Toxicol

PubMed ID: 35182693

Doi: 10.1016/j.fct.2022.112869

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RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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Structural characterization of the ANTAR antiterminator domain bound to RNA

Authors: James L Walshe, Rezwan Siddiquee, Karishma Patel, Sandro F Ataide

Journal: Nucleic Acids Res

PubMed ID: 35150565

Doi: 10.1093/nar/gkac074

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Structural characterization of the ANTAR antiterminator domain bound to RNA

Authors: James L Walshe, Rezwan Siddiquee, Karishma Patel, Sandro F Ataide

Journal: Nucleic Acids Res

PubMed ID: 35150565

Doi: 10.1093/nar/gkac074

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Neoantigens as potential vaccines in hepatocellular carcinoma

Authors: David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Belén Aparicio, Josune Egea, Ibon Tamayo-Uria, Sandra Hervás-Stubbs, Jorge García-Balduz, Carla Castro, Mercedes Iñarrairaegui, Maria Tagliamonte, Angela Mauriello, Beatrice Cavalluzzo, Luigi Buonaguro, Charlotte Rohrer, Kathrin Heim, Catrin Tauber, Maike Hofmann, Robert Thimme, Bruno Sangro, Pablo Sarobe

Journal: J Immunother Cancer

PubMed ID: 35193931

Doi: 10.1136/jitc-2021-003978

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Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial

Authors: Jorge Rojas-Serrano, Angelica Margarita Portillo-Vásquez, Ireri Thirion-Romero, Joel Vázquez-Pérez, Fidencio Mejía-Nepomuceno, Alejandra Ramírez-Venegas, Karla Midori Pérez-Kawabe, Rogelio Pérez-Padilla

Journal: PLoS ONE

PubMed ID: 35139097

Doi: 10.1371/journal.pone.0261980

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Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

Authors: Bertrand Simon, Hua Jane Lou, Clotilde Huet-Calderwood, Guangda Shi, Titus J Boggon, Benjamin E Turk, David A Calderwood

Journal: Nat Commun

PubMed ID: 35136069

Doi: 10.1038/s41467-022-28427-0

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Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase

Authors: Sabrina Patzelt, Manuela Pigors, Heiko Steenbock, Leonard Diel, Katharina Boch, Lenche Chakievska, Sven Künzel, Hauke Busch, Anke Fähnrich, Jürgen Brinckmann, Enno Schmidt

Journal: Front Immunol

PubMed ID: 35197965

Doi: 10.3389/fimmu.2021.812627

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A novel peptide-based electrochemical biosensor for breast cancer characterization over a poly 3-(3-aminophenyl) propionic acid matrix

Authors: Rafael da Fonseca Alves, Isabella Castro Martins, Diego Leoni Franco, Adriane das Graças Silva, Paula de Souza Santos, Luiz Ricardo Goulart, Yara Cristina de Paiva Maia, Alinne Tatiane Faria Silva, Thaise Gonçalves Araújo, Maria Del Pilar Taboada Sotomayor

Journal: Biosens Bioelectron

PubMed ID: 35217253

Doi: 10.1016/j.bios.2022.114081

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Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants

Authors: Sing Mei Lim, Hoi Lok Cheng, Huan Jia, Patthara Kongsuphol, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Shuvan Prashant Turaga, Sascha P Heussler, Jyoti Somani, Sharmila Sengupta, Dousabel M Y Tay, Megan E McBee, Barnaby E Young, Paul A MacAry, Hadley D Sikes, Peter R Preiser

Journal: Bioeng Transl Med

PubMed ID: 35600666

Doi: 10.1002/btm2.10293

Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS

Authors: Jordan M Anderson, Jing Li, Timothy A Springer

Journal: Mol Biol Cell

PubMed ID: 35108026

Doi: 10.1091/mbc.E21-11-0536

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The receptor CgIL-17R1 expressed in granulocytes mediates the CgIL-17 induced haemocytes proliferation in Crassostrea gigas

Authors: Wanqing Cao, Weilin Wang, Siqi Fan, Jialuo Li, Qing Li, Shasha Wu, Lingling Wang, Linsheng Song

Journal: Dev Comp Immunol