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Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial

Authors: Jorge Rojas-Serrano, Angelica Margarita Portillo-Vásquez, Ireri Thirion-Romero, Joel Vázquez-Pérez, Fidencio Mejía-Nepomuceno, Alejandra Ramírez-Venegas, Karla Midori Pérez-Kawabe, Rogelio Pérez-Padilla

Journal: PLoS ONE

PubMed ID: 35139097

Doi: 10.1371/journal.pone.0261980

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Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

Authors: Bertrand Simon, Hua Jane Lou, Clotilde Huet-Calderwood, Guangda Shi, Titus J Boggon, Benjamin E Turk, David A Calderwood

Journal: Nat Commun

PubMed ID: 35136069

Doi: 10.1038/s41467-022-28427-0

Products & Services: Proteins, Expression, Isolation and Analysis

Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase

Authors: Sabrina Patzelt, Manuela Pigors, Heiko Steenbock, Leonard Diel, Katharina Boch, Lenche Chakievska, Sven Künzel, Hauke Busch, Anke Fähnrich, Jürgen Brinckmann, Enno Schmidt

Journal: Front Immunol

PubMed ID: 35197965

Doi: 10.3389/fimmu.2021.812627

Products & Services: Proteins, Expression, Isolation and Analysis

A novel peptide-based electrochemical biosensor for breast cancer characterization over a poly 3-(3-aminophenyl) propionic acid matrix

Authors: Rafael da Fonseca Alves, Isabella Castro Martins, Diego Leoni Franco, Adriane das Graças Silva, Paula de Souza Santos, Luiz Ricardo Goulart, Yara Cristina de Paiva Maia, Alinne Tatiane Faria Silva, Thaise Gonçalves Araújo, Maria Del Pilar Taboada Sotomayor

Journal: Biosens Bioelectron

PubMed ID: 35217253

Doi: 10.1016/j.bios.2022.114081

Products & Services: DNA Sequencing

Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants

Authors: Sing Mei Lim, Hoi Lok Cheng, Huan Jia, Patthara Kongsuphol, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Shuvan Prashant Turaga, Sascha P Heussler, Jyoti Somani, Sharmila Sengupta, Dousabel M Y Tay, Megan E McBee, Barnaby E Young, Paul A MacAry, Hadley D Sikes, Peter R Preiser

Journal: Bioeng Transl Med

PubMed ID: 35600666

Doi: 10.1002/btm2.10293

Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS

Authors: Jordan M Anderson, Jing Li, Timothy A Springer

Journal: Mol Biol Cell

PubMed ID: 35108026

Doi: 10.1091/mbc.E21-11-0536

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The receptor CgIL-17R1 expressed in granulocytes mediates the CgIL-17 induced haemocytes proliferation in Crassostrea gigas

Authors: Wanqing Cao, Weilin Wang, Siqi Fan, Jialuo Li, Qing Li, Shasha Wu, Lingling Wang, Linsheng Song

Journal: Dev Comp Immunol

PubMed ID: 35183562

Doi: 10.1016/j.dci.2022.104376

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide identification and functional characterization of gene family reveal their involvement in response to drought stress in

Authors: Guangzhen Shi, Xinxia Zhu

Journal: PeerJ

PubMed ID: 35186477

Doi: 10.7717/peerj.12883

Products & Services: Protein Tools

Challenges of expressing recombinant human tissue factor as a secreted protein in

Authors: Mohammad Jalili-Nik, Mohammad Soukhtanloo, Majid Mojarrad, Mohammad Hadi Sadeghian, Baratali Mashkani

Journal: Prep Biochem Biotechnol

PubMed ID: 35133942

Doi: 10.1080/10826068.2021.2023823

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Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

Products & Services: Mutant Libraries

Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability

Authors: Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian

Journal: Bioengineered

PubMed ID: 35081868

Doi: 10.1080/21655979.2021.2024962

Products & Services: ORF cDNA Clones/MolecularCloud

Trans-seeding of Alzheimer-related tau protein by a yeast prion

Authors: Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkler

Journal: Alzheimers Dement

PubMed ID: 35142027

Doi: 10.1002/alz.12581

Products & Services: Mutant Libraries

Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2

Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger

Journal: Vaccines (Basel)

PubMed ID: 35214780

Doi: 10.3390/vaccines10020322

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SARS-CoV-2 neutralizing capacity among blood donors without prior COVID-19 symptomatic history vs blood donors with prior COVID-19 symptomatic history: A comparative study

Authors: Ushasree Ravula, Srinivasa Rao Chunchu, Srujaleswari Mooli, Ravi Naik, Pandu Ranga Rao Sarangapati

Journal: Transfus Clin Biol

PubMed ID: 35167958

Doi: 10.1016/j.tracli.2022.02.004

Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles

Authors: Yifei Yang, Zhenning Sun, Huopeng Li, Jijing Tian, Mingyong Chen, Tianlong Liu

Journal: Nanomaterials (Basel)

PubMed ID: 35214924

Doi: 10.3390/nano12040595

Products & Services: Plasmid DNA Preparation

Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles

Authors: Yifei Yang, Zhenning Sun, Huopeng Li, Jijing Tian, Mingyong Chen, Tianlong Liu

Journal: Nanomaterials (Basel)

PubMed ID: 35214924

Doi: 10.3390/nano12040595

Products & Services: Plasmid DNA Preparation

The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases

Authors: Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer, Alisa Markgraf, Philine Falk, Jakob Reich, Friedrich Riess, Philipp Girl, Katharina Müller, Katja Radon, Jessica Michelle Guggenbuehl Noller, Roman Wölfel, Michael Hoelscher, Inge Kroidl, Andreas Wieser, Laura Olbrich

Journal: Virology

PubMed ID: 35245784

Doi: 10.1016/j.virol.2022.02.002

Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering

Authors: Andreas Santamaria, Krishna C Batchu, Olga Matsarskaia, Sylvain F Prévost, Daniela Russo, Francesca Natali, Tilo Seydel, Ingo Hoffmann, Valérie Laux, Michael Haertlein, Tamim A Darwish, Robert A Russell, Giacomo Corucci, Giovanna Fragneto, Armando Maestro, Nathan R Zaccai

Journal: J Am Chem Soc

PubMed ID: 35157798

Doi: 10.1021/jacs.1c09856

Products & Services: Peptide Synthesis

Design of Synthetic Mammalian Promoters Using Highly Palindromic Subsequences

Authors: Polina Govorkova, Chee Ka Candice Lam, Kevin Truong

Journal: ACS Synth Biol

PubMed ID: 35225601

Doi: 10.1021/acssynbio.1c00600

Products & Services: PCR Cloning and Subcloning

Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor

Authors: Hongmao Sun, Nathan P Coussens, Carina Danchik, Leah M Wachsmuth, Mark J Henderson, Samarjit Patnaik, Matthew D Hall, Ashley L Molinaro, Dayle A Daines, Min Shen

Journal: J Chem Inf Model

PubMed ID: 35103473

Doi: 10.1021/acs.jcim.1c01188

Products & Services: Recombinant Antibody Expression

Preparative capillary electrophoresis (CE) fractionation of protein digests improves protein and peptide identification in bottom-up proteomics

Authors: Simon D Weaver, Naviya Schuster-Little, Rebecca J Whelan

Journal: Anal Methods

PubMed ID: 35175250

Doi: 10.1039/d1ay02145a

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Genome-wide identification and characterization of AINTEGUMENTA-LIKE (AIL) family genes in apple (Malus domestica Borkh)

Authors: Xiaolei Han, Kai Liu, Gaopeng Yuan, Shanshan He, Peihua Cong, Caixia Zhang

Journal: Genomics

PubMed ID: 35151838

Doi: 10.1016/j.ygeno.2022.110313

Products & Services: Protein Tools

Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Authors: Wallace H Liu, Robert E Miner, Brittany N Albaugh, Gene E Ananiev, Scott A Wildman, John M Denu

Journal: Biochemistry

PubMed ID: 35143176

Doi: 10.1021/acs.biochem.1c00698

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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Ecology and Diversity of Culturable Fungal Species Associated with Soybean Seedling Diseases in the Midwestern United States

Authors: Mirian F Pimentel, Ali Y Srour, Amanda J Warner, Jason P Bond, Carl A Bradley, John Rupe, Martin I Chilvers, J Alejandro Rojas, Janette L Jacobs, Christopher R Little, Alison E Robertson, Loren J Giesler, Dean Malvick, Kiersten Wise, Albert Tenuta, Ahmad M Fakhoury

Journal: J Appl Microbiol

PubMed ID: 35226387

Doi: 10.1111/jam.15507

Products & Services: PCR and Cloning

High-throughput split-protein profiling by combining transposon mutagenesis and regulated protein-protein interactions with deep sequencing

Authors: Kai Zhou, Thomas Litfin, Md Solayman, Huijun Zhao, Yaoqi Zhou, Jian Zhan

Journal: Int J Biol Macromol

PubMed ID: 35120933

Doi: 10.1016/j.ijbiomac.2022.01.173

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Authors: Minghua Deng, Jinhua Li, Bichen Xiao, Zhanpeng Ren, Ziqin Li, Haiyang Yu, Jiashen Li, Jianying Wang, Zhaowei Chen, Xianbao Wang

Journal: Anal Chem

PubMed ID: 35147418

Doi: 10.1021/acs.analchem.1c05309

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Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Authors: Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Matthew Gagne, Daniel Douek, C Todd DeMarco, Thomas N Denny, Thomas H Oguin, Alecia Brown, Wes Rountree, Yunfei Wang, Katayoun Mansouri, Robert J Edwards, Guido Ferrari, Gregory D Sempowski, Amanda Eaton, Juanjie Tang, Derek W Cain, Sampa Santra, Norbert Pardi, Drew Weissman, Mark Tomai, Christopher Fox, Ian N Moore, Hanne Andersen, Mark G Lewis, Hana Golding, Surender Khurana, Robert Seder, Ralph S Baric, David C Montefiori, Kevin O Saunders, Barton F Haynes

Journal: biorxiv

PubMed ID: 35118474

Doi: 10.1101/2022.01.26.477915

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Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Journal: biorxiv

PubMed ID: 35118474

Doi: 10.1101/2022.01.26.477915

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E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2

Authors: Stephanie N Langel, Francine L Kelly, David M Brass, Andrew E Nagler, Dylan Carmack, Joshua J Tu, Tatianna Travieso, Ria Goswami, Sallie R Permar, Maria Blasi, Scott M Palmer

Journal: Cell Death Discov

PubMed ID: 35169120

Doi: 10.1038/s41420-022-00855-3

Products & Services: Plasmid DNA Preparation

Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana

Authors: Xiaodong Su, Duanfang Cao, Xiaowei Pan, Lifang Shi, Zhenfeng Liu, Luca Dall'Osto, Roberto Bassi, Xinzheng Zhang, Mei Li

Journal: Mol Plant

PubMed ID: 35123031

Doi: 10.1016/j.molp.2022.01.020

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Structure−Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels

Authors: Naglaa Salem El-Sayed, Young-Woo Nam, Polina A Egorova, Hai Minh Nguyen, Razan Orfali, Mohammad Asikur Rahman, Grace Yang, Heike Wulff, Ilya Bezprozvanny, Keykavous Parang, Miao Zhang

Journal: J Med Chem

PubMed ID: 34962403

Doi: doi/10.1021/acs.jmedchem.1c01473.

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A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Authors: Qian Yuan, Qian Ren, Li Li , Huishi Tan, Meizhi Lu, Yuan Tian, Lu Huang, Boxin Zhao, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu

Journal: Nat Commun

PubMed ID: 35064106

Doi: 10.1038/s41467-022-28096-z

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A Novel Peptide Derived from Induces Apoptosis in Colorectal Cancer Cells through Mitochondria and the p38 MAPK Pathway

Authors: Chunlei Li, Sirui Zhang, Jianhua Zhu, Weijuan Huang, Yuanyuan Luo, Hui Shi, Dongbo Yu, Liguo Chen, Liyan Song, Rongmin Yu

Journal: Mar Drugs

PubMed ID: 35200639

Doi: 10.3390/md20020110

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Channelopathy-causing mutations in the SA/SB and HA/HB helices of K23 and K31 channels alter their apparent Ca sensitivity

Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang

Journal: Cell Calcium

PubMed ID: 35030515

Doi: 10.1016/j.ceca.2022.102538

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Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens

Authors: Xiahui Chen, Shoukai Kang, Md Ashif Ikbal, Zhi Zhao, Yuxin Pan, Jiawei Zuo, Liangcai Gu, Chao Wang

Journal: Biosens Bioelectron

PubMed ID: 35051851

Doi: 10.1016/j.bios.2022.113971

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping Critical Residues in ATG11's Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy

Authors: Mitchell D Meyer, Jasmine Winzeler, Sophia M Taylor, Alex Kilgore, Kimberly Edicha, Chase Chitwood, Zachary Spearin, S K Nadia Rahman Silvia, Ronith Chakraborty, Jesse E Smith, Bridget Kennedy, Carson Zois, Hayley Cawthon, Mukiri Gilruth, Steven K Backues

Journal: Front Cell Dev Biol

PubMed ID: 35118068

Doi: 10.3389/fcell.2021.775364

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Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression

Authors: Cláudia Martins-Lima, Vera Miranda-Gonçalves, João Lobo, Vera Constâncio, Pedro Leite-Silva, Catarina Guimarães-Teixeira, Sara Monteiro-Reis, José Pedro Sequeira, Mariana Cantante, Céline S Gonçalves, Bruno M Costa, Rui Henrique, Carmen Jerónimo

Journal: Cell Oncol (Dordr)

PubMed ID: 35064910

Doi: 10.1007/s13402-021-00657-2

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Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice

Authors: Anny Treat, Vianie Henri, Junke Liu, Joyce Shen, Mauricio Gil-Silva, Alejandro Morales, Avaneesh Rade, Kevin Joseph Tidgewell, Benedict Kolber, Young Shen

Journal: ACS Omega

PubMed ID: 35097287

Doi: 10.1021/acsomega.1c05727

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Peroxisomal ATP Uptake Is Provided by Two Adenine Nucleotide Transporters and the ABCD Transporters

Authors: Carlo W T van Roermund, Lodewijk IJlst, Nicole Linka, Ronald J A Wanders, Hans R Waterham

Journal: Front Cell Dev Biol

PubMed ID: 35127709

Doi: 10.3389/fcell.2021.788921

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An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine

Authors: Bo Wu, Zehua Li, Zepeng Kang, Chunling Ma, Haiyan Song, Fuping Lu, Zhiguang Zhu

Journal: Biosensors (Basel)

PubMed ID: 35200327

Doi: 10.3390/bios12020066

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CD8 T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2

Authors: Congling Qiu, Chanchan Xiao, Zhigang Wang, Guodong Zhu, Lipeng Mao, Xiongfei Chen, Lijuan Gao, Jieping Deng, Jun Su, Huanxing Su, Evandro Fei Fang, Zhang-Jin Zhang, Jikai Zhang, Caojun Xie, Jun Yuan, Oscar Junhong Luo, Li An Huang, Pengcheng Wang, Guobing Chen

Journal: Front Immunol

PubMed ID: 35116022

Doi: 10.3389/fimmu.2021.764949

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Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Authors: Jia-Wei Yang, Yu-Rou Lin, Ying-Ling Chu, Johnson H Y Chung, Huai-En Lu, Guan-Yu Chen

Journal: Commun Biol

PubMed ID: 35046486

Doi: 10.1038/s42003-022-03026-3

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Development and Evaluation of a Molecular Hepatitis A Virus Assay for Serum and Stool Specimens

Authors: Robert A Kozak, Candace Rutherford, Melissa Richard-Greenblatt, N Y Elizabeth Chau, Ana Cabrera, Mia Biondi, Jamie Borlang, Jaqueline Day, Carla Osiowy, Sumathi Ramachandran, Nancy Mayer, Laurel Glaser, Marek Smieja

Journal: Viruses

PubMed ID: 35062362

Doi: 10.3390/v14010159

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Differential T cell immune responses to deamidated adeno-associated virus vector

Authors: So Jin Bing, Sune Justesen, Wells W Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35211638

Doi: 10.1016/j.omtm.2022.01.005

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Characterization of a Novel Chimeric p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice

Authors: Leah Whittle, Ros Chapman, Michiel van Diepen, Edward P Rybicki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 35214669

Doi: 10.3390/vaccines10020210

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Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

Authors: Jing Zhao, Siyuan Gao, Yanli Guo, Qinglei Xu, Mingzheng Liu, Chunlei Zhang, Meng Cheng, Xianle Zhao, Allan P Schinckel, Bo Zhou

Journal: Biology (Basel)

PubMed ID: 35053133

Doi: 10.3390/biology11010135

Products & Services: Proteins, Expression, Isolation and Analysis

Azole-Resistant Alleles of in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors

Authors: Bao Gia Vu, W Scott Moye-Rowley

Journal: Antimicrob Agents Chemother

PubMed ID: 35007132

Doi: 10.1128/AAC.02098-21

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Three-repeat and four-repeat tau isoforms form different oligomers

Authors: Hedieh Shahpasand-Kroner, Jennifer Portillo, Carter Lantz, Paul M Seidler, Natalie Sarafian, Joseph A Loo, Gal Bitan

Journal: Protein Sci

PubMed ID: 34902187

Doi: 10.1002/pro.4257

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FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape

Authors: Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li

Journal: Theranostics

PubMed ID: 34976216

Doi: 10.7150/thno.66575

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Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

Authors: Sanjib K Mukherjee, Jim-Marcel Knop, Roland Winter

Journal: Chemistry

PubMed ID: 34882862

Doi: 10.1002/chem.202104182

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A model for DHX15 mediated disassembly of A-complex spliceosomes

Authors: Hannah M Maul-Newby, Angela N Amorello, Turvi Sharma, John H Kim, Matthew S Modena, Beth E Prichard, Melissa S Jurica

Journal: RNA

PubMed ID: 35046126

Doi: 10.1261/rna.078977.121

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Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Authors: Rhia Kundu, Janakan Sam Narean, Lulu Wang, Joseph Fenn, Timesh Pillay, Nieves Derqui Fernandez, Emily Conibear, Aleksandra Koycheva, Megan Davies, Mica Tolosa-Wright, Seran Hakki, Robert Varro, Eimear McDermott, Sarah Hammett, Jessica Cutajar, Ryan S Thwaites, Eleanor Parker, Carolina Rosadas, Myra McClure, Richard Tedder, Graham P Taylor, Jake Dunning, Ajit Lalvani

Journal: Nat Commun

PubMed ID: 35013199

Doi: 10.1038/s41467-021-27674-x

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Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria

Authors: Karol M Córdoba, Irantzu Serrano-Mendioroz, Daniel Jericó, María Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, María J Garrido, Paolo G V Martini, José Luis Lanciego, Jesús Prieto, Pedro Berraondo, Antonio Fontanellas

Journal: Sci Transl Med

PubMed ID: 35020410

Doi: 10.1126/scitranslmed.abc0700

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Physicochemical Characterization and In Vitro Digestibility Study of an In Silico Designed Recombinant Protein Enriched with Large Neutral Amino Acids and Lacking Phenylalanine for Phenylketonuria

Authors: Prakruthi Appaiah, L Sunil, Asha Martin, Prasanna Vasu

Journal: Protein J

PubMed ID: 35064867

Doi: 10.1007/s10930-021-10039-0

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Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Authors: Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B Weiner, Kate Broderick, Bin Wang

Journal: Hum Vaccin Immunother

PubMed ID: 35061975

Doi: 10.1080/21645515.2021.2016201

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Enzymatic synthesis of cellulose in space: gravity is a crucial factor for building cellulose II gel structure

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: Cellulose (Lond)

PubMed ID: 35125685

Doi: 10.1007/s10570-021-04399-0

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Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor

Authors: Longying Jiang, Xueke Liu, Hudie Wei, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Yongheng Chen

Journal: Biochem Biophys Res Commun

PubMed ID: 35091108

Doi: 10.1016/j.bbrc.2022.01.069

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Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

Authors: Grega Popovic, Nicholas C Kirby, Taylor C Dement, Kristine M Peterson, Caroline E Daub, Heather A Belcher, Martin Guthold, Adam R Offenbacher, Nathan E Hudson

Journal: Int J Mol Sci

PubMed ID: 35162976

Doi: 10.3390/ijms23031054

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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Authors: Enquan Xu, Ravindra Boddu, Hisham A Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M Carlisle, Elliot J Lefkowitz, Ashley S Harms, Etty N Benveniste, Talene A Yacoubian, Laura A Volpicelli-Daley, David G Standaert, Andrew B West

Journal: Mol Neurodegener

PubMed ID: 35012605

Doi: 10.1186/s13024-021-00509-5

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Distribution of serotypes and antibiotic resistance of invasive Pseudomonas aeruginosa in a multi-country collection

Authors: Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D Tapia, J Kristie Johnson, Samba O Sow, Joshua T Thaden, Vance G Fowler, Karen A Krogfelt, Annelie Brauner, Efthymia Protonotariou, Eirini Christaki, Yuichiro Shindo, Andrea L Kwa, Sadia Shakoor, Ashika Singh-Moodley, Olga Perovic, Jan Jacobs, Octavie Lunguya, Raphael Simon, Alan S Cross, Sharon M Tennant

Journal: BMC Microbiol

PubMed ID: 34991476

Doi: 10.1186/s12866-021-02427-4

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Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

Authors: Kylie M Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Himanshi Chawla, Jianqiu Du, Nicholas J Tursi, Alan Moore, Jared Adolf-Bryfogle, Mansi Purwar, Emma L Reuschel, Drew Frase, Matthew Sullivan, Benjamin Fry, Igor Maricic, Viviane M Andrade, Christel Iffland, Max Crispin, Kate E Broderick, Laurent M P F Humeau, Ami Patel, Trevor R F Smith, Jesper Pallesen, David B Weiner, Daniel W Kulp

Journal: Cell Rep

PubMed ID: 35090597

Doi: 10.1016/j.celrep.2022.110318

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Identification of a plant endophytic growth-promoting bacteria capable of inhibiting cadmium uptake in rice

Authors: Wei Tian, Le Li, Xiao Xiao, Huili Wu, Yulong Wang, Zhaoyang Hu, Nahmina Begum, Yiping Zou, Laiqing Lou, Ming Chang, Qingsheng Cai

Journal: J Appl Microbiol

PubMed ID: 34216530

Doi: 10.1111/jam.15201

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CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors

Authors: Daniela Nasif, Sebastian Real, María Roqué, María T Branham

Journal: Breast Cancer

PubMed ID: 35094293

Doi: 10.1007/s12282-022-01334-4

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Nanobody-based anti-CD22-chimeric antigen receptor T cell immunotherapy exhibits improved remission against B-cell acute lymphoblastic leukemia

Authors: Tingting Zhang, Tian Wang, Fengtao You, Zixuan Li, Dan Chen, Kailu Zhang, Shuaiyu Tian, Binjie Sheng, Hai Wu, Licui Jiang, Renyuxue Ma, Gangli An, Huimin Meng, Lin Yang

Journal: Transpl Immunol

PubMed ID: 35051588

Doi: 10.1016/j.trim.2022.101538

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Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workers

Authors: Maria Nikolova, Yana Todorova, Radoslava Emilova, Iva Trifonova, Teodora Gladnishka, Nina Petrova-Yancheva, Tatyana Chervenyakova, Elena Dragusheva, Georgi Popov, Iva Christova

Journal: J Med Virol

PubMed ID: 34997611

Doi: 10.1002/jmv.27572

MPP1 Determines the Mobility of Flotillins and Controls the Confinement of Raft-Associated Molecules

Authors: Agnieszka Biernatowska, Karolina Wójtowicz, Tomasz Trombik, Aleksander F Sikorski, Aleksander Czogalla

Journal: Cells

PubMed ID: 35159121

Doi: 10.3390/cells11030311

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A Novel Potent Carrier for Unconventional Protein Export in

Authors: Magnus Philipp, Kai P Hussnaetter, Michèle Reindl, Kira Müntjes, Michael Feldbrügge, Kerstin Schipper

Journal: Front Cell Dev Biol

PubMed ID: 35083222

Doi: 10.3389/fcell.2021.816335

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Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Authors: Anusyah Rathakrishnan, Samuel Connell, Vlad Petrovan, Katy Moffat, Lynnette C Goatley, Tamara Jabbar, Pedro J Sánchez-Cordón, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 35044212

Doi: 10.1128/jvi.01899-21

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Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding

Authors: Natalie Jay, Sean R Duffy, D Fernando Estrada

Journal: Biochemistry

PubMed ID: 34979083

Doi: 10.1021/acs.biochem.1c00770

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Blue-light receptor phototropin 1 suppresses immunity to promote Phytophthora infestans infection

Authors: Shaista Naqvi, Qin He, Franziska Trusch, Huishan Qiu, Jasmine Pham, Qingguo Sun, John M Christie, Eleanor M Gilroy, Paul R J Birch

Journal: New Phytol

PubMed ID: 34923631

Doi: 10.1111/nph.17929

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Expression, purification and characterization of the suppressor of copper sensitivity (Scs) B membrane protein from Proteus mirabilis

Authors: Russell J Jarrott, Emily J Furlong, Guillaume A Petit, David Drew, Jennifer L Martin, Maria A Halili

Journal: Protein Expr Purif

PubMed ID: 35026386

Doi: 10.1016/j.pep.2022.106047

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Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to regulate TORC1 signaling

Authors: Shreya Goyal, Verónica A Segarra, Aaron M Stetcher, Andrew W Truman, Adam M Reitzel, Richard J Chi

Journal: Traffic

PubMed ID: 35098628

Doi: 10.1111/tra.12833

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The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release

Authors: Mila M Paul, Sven Dannhäuser, Lydia Morris, Achmed Mrestani, Martha Hübsch, Jennifer Gehring, Georgios N Hatzopoulos, Martin Pauli, Genevieve M Auger, Grit Bornschein, Nicole Scholz, Dmitrij Ljaschenko, Martin Müller, Markus Sauer, Hartmut Schmidt, Robert J Kittel, Aaron DiAntonio, Ioannis Vakonakis, Manfred Heckmann, Tobias Langenhan

Journal: Brain

PubMed ID: 35022694

Doi: 10.1093/brain/awac011

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Investigation of putative antimicrobial peptides in Carassius gibel, revealing a practical approach to screening antimicrobials

Authors: Yujun Zhang, Ping Deng, Caijiao Dai, Mengke Wu, Xueqin Liu, Lijuan Li, Xiaoyi Pan, Junfa Yuan

Journal: Fish Shellfish Immunol

PubMed ID: 34990806

Doi: 10.1016/j.fsi.2021.12.050

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Sterility of Sustained-release Buprenorphine

Authors: Shraddha I Cantara, Crystal Gergye, Vanessa K Lee, Michael Huerkamp

Journal: J Am Assoc Lab Anim Sci

PubMed ID: 35082006

Doi: 10.30802/AALAS-JAALAS-21-000105

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Core-shell "loading-type" nanomaterials towards: Simultaneous imaging analysis of glutathione and microRNA

Authors: Lin-Lin Lu, Qin Zhang, Yu Gu, Xiang-Ling Li, Jing Jing Xie

Journal: Anal Chim Acta

PubMed ID: 35151402

Doi: 10.1016/j.aca.2022.339551

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Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses

Authors: Bo Wang, Shuang Li, Yongbo Qiao, Yu Fu, Jiaojiao Nie, Shun Jiang, Xin Yao, Yi Pan, Linye Zhao, Congmei Wu, Yuhua Shi, Yuhe Yin, Yaming Shan

Journal: J Nanobiotechnology

PubMed ID: 35012571

Doi: 10.1186/s12951-021-01229-0

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Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates

Authors: Xi Liu, Shuliu Dai, Yu Zhou, Jinyue Liu, Dong Li, Jun Zhang, Yushan Zhu, Qiao Zhao, Yue Feng, Yi Zhang

Journal: Biochem Biophys Res Commun

PubMed ID: 35066379

Doi: 10.1016/j.bbrc.2022.01.037

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Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates

Authors: Xi Liu, Shuliu Dai, Yu Zhou, Jinyue Liu, Dong Li, Jun Zhang, Yushan Zhu, Qiao Zhao, Yue Feng, Yi Zhang

Journal: Biochem Biophys Res Commun

PubMed ID: 35066379

Doi: 10.1016/j.bbrc.2022.01.037

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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Authors: Zhengqi Zha, Yaoyao Liu, Yinghua Miao, Shiying Liao, Su-Yan Wang, Huiling Tang, Hongping Yin

Journal: Int J Biol Macromol

PubMed ID: 34998873

Doi: 10.1016/j.ijbiomac.2021.12.098

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Nitroreduction of flutamide by NADPH: Cytochrome P450 reductase

Authors: Mohd Faheem Khan, Cormac D Murphy

Journal: Biochem Biophys Rep

PubMed ID: 35097225

Doi: 10.1016/j.bbrep.2022.101209

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Nitroreduction of flutamide by NADPH: Cytochrome P450 reductase

Authors: Mohd Faheem Khan, Cormac D Murphy

Journal: Biochem Biophys Rep

PubMed ID: 35097225

Doi: 10.1016/j.bbrep.2022.101209

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Bio-nanocapsules for oriented immobilization of DNA aptamers on aptasensors

Authors: Masumi Iijima, Yuki Yamada, Hideo Nakano, Tsutomu Nakayama, Shun'ichi Kuroda

Journal: Analyst

PubMed ID: 35023508

Doi: 10.1039/d1an02278d

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Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test

Authors: Qiao Wang, Lili Feng, Haohai Zhang, Juehua Gao, Changchuin Mao, Esther Landesman-Bollag, Gustavo Mostoslavsky, Justin M Lunderberg, Weina Zheng, Shushun Hao, Wenda Gao

Journal: Antib Ther

PubMed ID: 35146332

Doi: 10.1093/abt/tbac004

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Degradation of dimethachlon by a newly isolated bacterium Paenarthrobacter sp strain JH-1 relieves its toxicity against Chlorella ellipsoidea

Authors: Mingliang Zhang, Wankui Jiang, Siyuan Gao, Qian Zhu, Zhijian Ke, Mingli Jiang, Jiguo Qiu, Qing Hong

Journal: Environ Res

PubMed ID: 35031339

Doi: 10.1016/j.envres.2022.112706

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Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis

Authors: Qian Guo, Tingting Guo, Yuanyuan Sun, Tianrong Chen

Journal: Neuroreport

PubMed ID: 34874325

Doi: 10.1097/WNR.0000000000001743

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Involvement of β-cyanoalanine synthase (β-CAS) and sulfurtransferase (ST) in cyanide (CN) assimilation in rice seedlings

Authors: Yu-Xi Feng, Cheng-Zhi Li, Yu-Juan Lin, Xiao-Zhang Yu

Journal: Chemosphere

PubMed ID: 35101430

Doi: 10.1016/j.chemosphere.2022.133789

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Crystal Structure Analysis and IgE Epitope Mapping of Allergic Predominant Region in Filamin C, Scy p 9

Authors: Xin-Rong He, Yang Yang, Shuai Kang, Ye-Xin Chen, Pei-Yi Zheng, Gui-Xia Chen, Xiao-Mei Chen, Min-Jie Cao, Tengchuan Jin, Guang-Ming Liu

Journal: J Agric Food Chem

PubMed ID: 35040643

Doi: 10.1021/acs.jafc.1c07922

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Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells

Authors: Yong Bian, Gang Yin, Gang Wang, Tiantian Liu, Li Liang, Xinyue Yang, Wen Zhang, Decai Tang

Journal: Cell Biol Toxicol

PubMed ID: 35083610

Doi: 10.1007/s10565-021-09681-2

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Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells

Authors: Yong Bian, Gang Yin, Gang Wang, Tiantian Liu, Li Liang, Xinyue Yang, Wen Zhang, Decai Tang

Journal: Cell Biol Toxicol

PubMed ID: 35083610

Doi: 10.1007/s10565-021-09681-2

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Roles of Close Homologues SigB and SigD in Heat and High Light Acclimation of the Cyanobacterium sp PCC 6803

Authors: Otso Turunen, Satu Koskinen, Juha Kurkela, Outi Karhuvaara, Kaisa Hakkila, Taina Tyystjärvi

Journal: Life (Basel)

PubMed ID: 35207450

Doi: 10.3390/life12020162

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Roles of Close Homologues SigB and SigD in Heat and High Light Acclimation of the Cyanobacterium sp PCC 6803

Authors: Otso Turunen, Satu Koskinen, Juha Kurkela, Outi Karhuvaara, Kaisa Hakkila, Taina Tyystjärvi

Journal: Life (Basel)

PubMed ID: 35207450

Doi: 10.3390/life12020162

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Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence

Authors: Stefano Perni, Kurt Beam

Journal: J Gen Physiol

PubMed ID: 35089322

Doi: 10.1085/jgp.202113024

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CryoEM analysis of small plant biocatalysts at sub-2 Å resolution

Authors: Nicole Dimos, Carl P O Helmer, Andrea M Chánique, Markus C Wahl, Robert Kourist, Tarek Hilal, Bernhard Loll

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 34981767

Doi: 10.1107/S205979832101216X

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Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia

Authors: Stefan Hirschberg, Anton Dvorzhak, Seyed M A Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn

Journal: Front Cell Neurosci

PubMed ID: 35173582

Doi: 10.3389/fncel.2021.792652

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Journal: Front Cell Neurosci

PubMed ID: 35173582

Doi: 10.3389/fncel.2021.792652

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DNA methylation analysis of ELOVL2 gene using droplet digital PCR for age estimation purposes

Authors: Licínio Manco, Helena Correia Dias

Journal: FORENSIC SCI INT

PubMed ID: 35131731

Doi: 10.1016/j.forsciint.2022.111206

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