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Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Authors: Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti

Journal: Lipids Health Dis

PubMed ID: 35614477

Doi: 10.1186/s12944-022-01654-6

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Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

Authors: Lili Li, Meiling Gao, Peng Jiao, Shulong Zu, Yong-Qiang Deng, Dingyi Wan, Yang Cao, Jing Duan, Saba R Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng-Feng Qin, Yu Guo, Genhong Cheng, Heng Yang

Journal: Cell Biosci

PubMed ID: 35581593

Doi: 10.1186/s13578-022-00794-7

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Identification, expression and subcellular localization of Orc1 in the microsporidian Nosema bombycis

Authors: Fuzhen Sun, Guanyu Zhu, Ping He, Erjun Wei, Runpeng Wang, Qiang Wang, Xudong Tang, Yiling Zhang, Zhongyuan Shen

Journal: Gene

PubMed ID: 35609797

Doi: 10.1016/j.gene.2022.146607

Products & Services: Protein and Antibody Isolation

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Authors: Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Journal: Biomedicines

PubMed ID: 35740244

Doi: 10.3390/biomedicines10061223

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Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

Authors: Erin E Deans, Judy L M Kotler, Wei-Shao Wei, Timothy O Street

Journal: J Mol Biol

PubMed ID: 35597552

Doi: 10.1016/j.jmb.2022.167638

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A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Authors: Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D Weber, Cristian Smerdou

Journal: Cell Biosci

PubMed ID: 35641984

Doi: 10.1186/s13578-022-00803-9

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Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay

Authors: Phong Phan, Di Liang, Min Zhao, Russell C Wyeth, Conor Fogarty, Mary G Duke, Donald P McManus, Tianfang Wang, Scott F Cummins

Journal: Sci Rep

PubMed ID: 35581232

Doi: 10.1038/s41598-022-11996-x

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Characterization of the Biomass Degrading Enzyme GuxA from

Authors: Neal N Hengge, Sam J B Mallinson, Patthra Pason, Vladimir V Lunin, Markus Alahuhta, Daehwan Chung, Michael E Himmel, Janet Westpheling, Yannick J Bomble

Journal: Int J Mol Sci

PubMed ID: 35682749

Doi: 10.3390/ijms23116070

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Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral , Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme

Authors: Nicole E Avalon, Jordan Nafie, Carolina De Marco Verissimo, Luke C Warrensford, Sarah G Dietrick, Amanda R Pittman, Ryan M Young, Fiona L Kearns, Tracess Smalley, Jennifer M Binning, John P Dalton, Mark P Johnson, H Lee Woodcock, A Louise Allcock, Bill J Baker

Journal: J Nat Prod

PubMed ID: 35549259

Doi: 10.1021/acs.jnatprod.2c00054

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A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection

Authors: Mahnaz D Gholami, Kristyan Guppy-Coles, Serena Nihal, Daman Langguth, Prashant Sonar, Godwin A Ayoko, Chamindie Punyadeera, Emad L Izake

Journal: Talanta

PubMed ID: 35660992

Doi: 10.1016/j.talanta.2022.123630

Products & Services: Recombinant Antibody Expression

Reduction of Influenza A Virus Transmission in Mice by a Universal Intranasal Vaccine Candidate is Long-Lasting and Does Not Require Antibodies

Authors: Graeme E Price, Chia-Yun Lo, Julia A Misplon, Suzanne L Epstein

Journal: J Virol

PubMed ID: 35638848

Doi: 10.1128/jvi.00320-22

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Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Authors: Zhi Liu, Tian Chen, Sicheng Zhang, Tianfang Yang, Yun Gong, Hong-Wen Deng, Ding Bai, Weidong Tian, YiPing Chen

Journal: Elife

PubMed ID: 35503096

Doi: 10.7554/eLife.77740

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The Carotenoid Esterification Gene Controls Pale-Yellow Petal Color in Flowering Chinese Cabbage ( L subsp )

Authors: Peirong Li, Sirui Lv, Deshuang Zhang, Tongbing Su, Xiaoyun Xin, Weihong Wang, Xiuyun Zhao, Yangjun Yu, Yaowei Zhang, Shuancang Yu, Fenglan Zhang

Journal: Front Plant Sci

PubMed ID: 35592555

Doi: 10.3389/fpls.2022.844140

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Novel small molecules targeting bZIP23 TF improve stomatal conductance and photosynthesis under mild drought stress by regulating ABA

Authors: Vanitha Pa, Preethi Vijayaraghavareddy, Akshay Uttarkar, Akashata Dawane, Sujitha D, Ashwin V, Babitha Kc, Vidya Niranjan, Sheshshayee Ms, Anuradha Cv, Udayakumar Makarla, Ramu S Vemanna

Journal: FEBS J

PubMed ID: 35445538

Doi: 10.1111/febs.16461

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Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway

Authors: Tian Xie, Jun Yuan, Ling Mei, Ping Li, Ruijie Pan

Journal: Exp Ther Med

PubMed ID: 35747154

Doi: 10.3892/etm.2022.11396

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Performance analysis among multiple fully automated anti-SARS-CoV-2 antibody measurement reagents: A potential indicator for the correlation of protection in the antibody titer

Authors: Ryo Kobayashi, Ema Suzuki, Ryosei Murai, Makito Tanaka, Yoshihiro Fujiya, Satoshi Takahashi

Journal: J Infect Chemother

PubMed ID: 35667939

Doi: 10.1016/j.jiac.2022.05.016

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Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation

Authors: Debabrata Das, Shalini Trivedi, Jitka Blazícková, Swathi Arur, Nicola Silva

Journal: G3 (Bethesda)

PubMed ID: 35389463

Doi: 10.1093/g3journal/jkac079

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Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome

Authors: Flavio Signorelli, Gustavo Guimarães Moreira Balbi, Nadia E Aikawa, Clovis A Silva, Léonard de Vinci Kanda Kupa, Ana C Medeiros-Ribeiro, Emily Fn Yuki, Sandra G Pasoto, Carla Gs Saad, Eduardo F Borba, Luciana Parente Costa Seguro, Tatiana Pedrosa, Vitor Antonio de Angeli Oliveira, Ana Luisa Cerqueira de Sant'Ana Costa, Carolina T Ribeiro, Roseli Eliana Beseggio Santos, Danieli Castro Oliveira Andrade, Eloisa Bonfá

Journal: Lupus

PubMed ID: 35593174

Doi: 10.1177/09612033221102073

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Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Authors: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N Hobbie, Sven Panke, Martin Held

Journal: BMC Biol

PubMed ID: 35578204

Doi: 10.1186/s12915-022-01304-4

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CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4

Authors: Yajuan Zhang, Hongxiu Zhang, Xiaolei Zhang, Bin Liu

Journal: Dis Markers

PubMed ID: 35655916

Doi: 10.1155/2022/7155525

Products & Services: Plasmid DNA Preparation

The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization

Authors: Xiang Chen, Justin M Mirazee, Katarzyna A Skorupka, Hiroshi Matsuo, Philippe Youkharibache, Naomi Taylor, Kylie J Walters

Journal: J Magn Reson

PubMed ID: 35617919

Doi: 10.1016/j.jmr.2022.107234

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SOLVx therapeutics vaccine - Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2

Authors: Md Shamsuddin Sultan Khan, John A Catanzaro

Journal: Biomed Pharmacother

PubMed ID: 35653885

Doi: 10.1016/j.biopha.2022.113212

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Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Authors: Qing Zhang, Jun Ren, Fangfang Wang, Manman Pan, Long Cui, Mingqian Li, Fan Qu

Journal: Free Radic Biol Med

PubMed ID: 35594990

Doi: 10.1016/j.freeradbiomed.2022.05.010

Products & Services: Protein Electrophoresis and Western

Multiple stem-loop primers induced cascaded loop-mediated isothermal amplification for direct recognition and specific detection of circular RNAs

Authors: Xin Liu, Pengbo Zhang, Kejian Gao, Xiaoyu Wang, Zhengping Li

Journal: Analyst

PubMed ID: 35506753

Doi: 10.1039/d2an00261b

Products & Services: Protein and Antibody Isolation

A Transfected Parasite Line Expressing eGFP Is Able to Complete the Full Life Cycle of the Parasite in Mammalian and Tick Hosts

Authors: Wendell C Johnson, Hala E Hussein, Janaina Capelli-Peixoto, Jacob M Laughery, Naomi S Taus, Carlos E Suarez, Massaro W Ueti

Journal: Pathogens

PubMed ID: 35745477

Doi: 10.3390/pathogens11060623

Products & Services: Plasmid DNA Preparation

Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules

Authors: Janine Dilchert, Martin Hofmann, Felix Unverdorben, Roland Kontermann, Sebastian Bunk

Journal: Antibodies (Basel)

PubMed ID: 35645207

Doi: 10.3390/antib11020034

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Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine

Authors: Shigehiro Tsukahara, Masaki Shiota, Dai Takamatsu, Shohei Nagakawa, Takashi Matsumoto, Ryo Kiyokoba, Mikako Yagi, Daiki Setoyama, Nozomi Noda, Shinya Matsumoto, Tetsutaro Hayashi, Alberto Contreras-Sanz, Peter C Black, Junichi Inokuchi, Kenichi Kohashi, Yoshinao Oda, Takeshi Uchiumi, Masatoshi Eto, Dongchon Kang

Journal: Sci Rep

PubMed ID: 35595780

Doi: 10.1038/s41598-022-12528-3

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LncRNA JPX Promotes Esophageal Squamous Cell Carcinoma Progression by Targeting miR-516b-5p/VEGFA Axis

Authors: Yi He, Rong Hua, Yang Yang, Bin Li, Xufeng Guo, Zhigang Li

Journal: Cancers (Basel)

PubMed ID: 35681693

Doi: 10.3390/cancers14112713

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Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

Authors: Christine S Hopp, Jeff Skinner, Sarah L Anzick, Christopher M Tipton, Mary E Peterson, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Craig Martens, Boubacar Traore, Peter D Crompton

Journal: Sci Immunol

PubMed ID: 35559666

Doi: 10.1126/sciimmunol.abn1250

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Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti-spike neutralizing IgG to SARS-CoV-2 variants, but preserved antigen-specific T cell responses

Authors: Brendan Beaton, Sarah C Sasson, Katherine Rankin, Juliette Raedemaeker, Alexander Wong, Priyanka Hastak, Chansavath Phetsouphanh, Andrew Warden, Vera Klemm, C Mee Ling Munier, Alexandra Carey Hoppe, Fiona Tea, Aleha Pillay, Alberto Ospina Stella, Anupriya Aggarwal, Orly Lavee, Ian D Caterson, Stuart Turville, Anthony D Kelleher, Fabienne Brilot, Judith Trotman

Journal: Am J Hematol

PubMed ID: 35607995

Doi: 10.1002/ajh.26619

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Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

Authors: Prabhakargouda B Patil, Shaibal Kumar Dasgupta, Kevin Gorman, Angela Pickl-Herk, Mirel Puinean, Andrew McKemey, Bharat Char, Usha B Zehr, Shirish R Barwale

Journal: PLoS Negl Trop Dis

PubMed ID: 35576193

Doi: 10.1371/journal.pntd.0010315

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Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens

Authors: Javier Ibanez, Rolf Fendel, Freia-Raphaella Lorenz, Patricia Granados-Bayon, Sina Brückner, Meral Esen, Mihály Sulyok, Zita Sulyok, Steffen Borrmann, Petra Bacher, Alexander Scheffold, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmüller

Journal: npj Vaccines

PubMed ID: 35641527

Doi: 10.1038/s41541-022-00473-1

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Carboxymethylcellulose biofunctionalized ternary quantum dots for subcellular-targeted brain cancer nanotheranostics

Authors: Alexandra A P Mansur, Mayara R B Paiva, Oliver A L Cotta, Luciana M Silva, Isadora C Carvalho, Nádia S V Capanema, Sandhra M Carvalho, Érica A Costa, Nelson R Martin, Roselene Ecco, Beatriz S Santos, Silvia L Fialho, Zélia I P Lobato, Herman S Mansur

Journal: Int J Biol Macromol

PubMed ID: 35513094

Doi: 10.1016/j.ijbiomac.2022.04.207

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Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration

Authors: Zhigang Xie, Vytas A Bankaitis

Journal: Cell Rep

PubMed ID: 35649377

Doi: 10.1016/j.celrep.2022.110869

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The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Authors: Robert D Murphy, Tiantian Chen, Jianping Lin, Rongjun He, Li Wu, Caden R Pearson, Savita Sharma, Carl D Vander Kooi, Anthony P Sinai, Zhong-Yin Zhang, Craig W Vander Kooi, Matthew S Gentry

Journal: J Biol Chem

PubMed ID: 35640720

Doi: 10.1016/j.jbc.2022.102089

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Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Authors: Robert Blassberg, Harshil Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M Joaquina Delás, James Briscoe

Journal: Nat Cell Biol

PubMed ID: 35550614

Doi: 10.1038/s41556-022-00910-2

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Candidate Chemosensory Genes Identified in the Adult Antennae of and Binding Property of Odorant-Binding Protein 15

Authors: Xiao Li, Jian-Wen Li, Wen-Xiu Sun, Wei Li, Hua-Yuan Gao, Tong-Xian Liu, Ming-Jing Qu

Journal: Front Physiol

PubMed ID: 35711318

Doi: 10.3389/fphys.2022.907667

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Structural variation between neuropeptide isoforms affects function in the lobster cardiac system

Authors: Audrey J Muscato, Daniel J Powell, Warsameh Bulhan, Evalyn S Mackenzie, Alixander Pupo, Madeline Rolph, Andrew E Christie, Patsy S Dickinson

Journal: Gen Comp Endocrinol

PubMed ID: 35623446

Doi: 10.1016/j.ygcen.2022.114065

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Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment

Authors: Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng, Peng-Fei Tu

Journal: ACS Cent Sci

PubMed ID: 36032766

Doi: 10.1021/acscentsci.2c00107

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Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant

Authors: Kanwal Khan, Salman Ali Khan, Khurshid Jalal, Zaheer Ul-Haq, Reaz Uddin

Journal: Virology

PubMed ID: 35576833

Doi: 10.1016/j.virol.2022.05.001

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Combinatorial Engineering Enables Photoautotrophic Growth in High Cell Density Phosphite-Buffered Media to Support Engineered Chlamydomonas reinhardtii Bio-Production Concepts

Authors: Malak N Abdallah, Gordon B Wellman, Sebastian Overmans, Kyle J Lauersen

Journal: Frontiers in Microbiology

Doi: 10.3389/fmicb.2022.885840

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Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

Authors: Jack Rhodes , Andra-Octavia Roman , Marta Bjornson , Benjamin Brandt , Paul Derbyshire , Michele Wyler , Marc W Schmid , Frank LH Menke , Julia Santiago , Cyril Zipfel

Journal: Elife

Doi: doi.org/10.7554/eLife.74687

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Antigen mimicry as an effective strategy to induce CSPG4-targeted immunity in dogs with oral melanoma: a veterinary trial

Authors: Federica Riccardo, Lidia Tarone, Mariateresa Camerino, Davide Giacobino, Selina Iussich, Giuseppina Barutello, Maddalena Arigoni, Laura Conti, Elisabetta Bolli, Elena Quaglino, Irene Fiore Merighi, Emanuela Morello, Alfredo Dentini, Soldano Ferrone, Paolo Buracco, Federica Cavallo

Journal: J Immunother Cancer

PubMed ID: 35580930

Doi: 10.1136/jitc-2021-004007

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A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

Authors: Junyu Chen, Pui Wang, Lunzhi Yuan, Liang Zhang, Limin Zhang, Hui Zhao, Congjie Chen, Xijing Wang, Jinle Han, Yaode Chen, Jizong Jia, Zhen Lu, Junping Hong, Zicen Lu, Qian Wang, Rirong Chen, Ruoyao Qi, Jian Ma, Min Zhou, Huan Yu, Chunlan Zhuang, Xiaohui Liu, Qiangyuan Han, Guosong Wang, Yingying Su, Quan Yuan, Tong Cheng, Ting Wu, Xiangzhong Ye, Tianying Zhang, Changgui Li, Jun Zhang, Huachen Zhu, Yixin Chen, Honglin Chen, Ningshao Xia

Journal: Sci Bull (Beijing)

PubMed ID: 35637645

Doi: 10.1016/j.scib.2022.05.018

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Infrared Spectroscopic Study of Multi-Component Lipid Systems: A Closer Approximation to Biological Membrane Fluidity

Authors: Maria C Klaiss-Luna, Marcela Manrique-Moreno

Journal: Membranes (Basel)

PubMed ID: 35629860

Doi: 10.3390/membranes12050534

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BcWRKY1 confers salt sensitivity via inhibiting Reactive oxygen species scavenging

Authors: Shuilin Yuan, Die Hu, Yuan Wang, Cen Shao, Tongkun Liu, Changwei Zhang, Feng Cheng, Xilin Hou, Ying Li

Journal: Plant Mol Biol

PubMed ID: 35553313

Doi: 10.1007/s11103-022-01272-x

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Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese

Authors: Rie Midorikawa, Moriyuki Nakama, Hiroshi Furukawa, Shomi Oka, Takashi Higuchi, Hideaki Nagai, Nobuhiro Nagai, Shigeto Tohma

Journal: Viruses

PubMed ID: 35632710

Doi: 10.3390/v14050965

B-Cell-Epitope-Based Fluorescent Quantum Dot Biosensors for SARS-CoV-2 Enable Highly Sensitive COVID-19 Antibody Detection

Authors: Yucheng Zheng, Kun Song, Kun Cai, Linlin Liu, Dixiao Tang, Wenbo Long, Bohui Zhai, Jianjun Chen, Yanbing Tao, Yunong Zhao, Simeng Liang, Qing Huang, Qianyun Liu, Qi Zhang, Yu Chen, Yingle Liu, Huayao Li, Ping Wang, Ke Lan, Huan Liu, Ke Xu

Journal: Viruses

PubMed ID: 35632772

Doi: 10.3390/v14051031

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Pytheas: a software package for the automated analysis of RNA sequences and modifications via tandem mass spectrometry

Authors: Luigi D'Ascenzo, Anna M Popova, Scott Abernathy, Kai Sheng, Patrick A Limbach, James R Williamson

Journal: Nat Commun

PubMed ID: 35505047

Doi: 10.1038/s41467-022-30057-5

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Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies

Authors: Kerri Beth Boggs, Kearstin Edmonds, Nicolas Cifuentes-Munoz, Farah El Najjar, Conny Ossandón, McKenna Roe, Chao Wu, Carole L Moncman, Trevor P Creamer, Gaya K Amarasinghe, Daisy W Leung, Rebecca Ellis Dutch

Journal: MBio

PubMed ID: 35536005

Doi: 10.1128/mbio.01099-22

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DNA tile self-assembly driven by antibody-mediated four-way branch migration

Authors: Xingdi Cui, Yuan Liu, Qiang Zhang

Journal: Analyst

PubMed ID: 35467671

Doi: 10.1039/d1an02273c

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Rgs16 promotes antitumor CD8 T cell exhaustion

Authors: Nina Weisshaar, Jingxia Wu, Yanan Ming, Alaa Madi, Agnes Hotz-Wagenblatt, Sicong Ma, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Kerstin Mohr, Tilo Schlimbach, Nora Ten Bosch, Franziska Hertel, Lisann Müller, Hannah Byren, Mona Wang, Helena Borgers, Mareike Munz, Lukas Schmitt, Franciscus van der Hoeven, Ulrich Kloz, Rafael Carretero, Nikolai Schleußner, Rene-Filip Jackstadt, Ilse Hofmann, Guoliang Cui

Journal: Sci Immunol

PubMed ID: 35622904

Doi: 10.1126/sciimmunol.abh1873

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Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation

Authors: Vidhyavathi Raman, Clemencia M Rojas, Balaji Vasudevan, Kevin Dunning, Jaydeep Kolape, Sunhee Oh, Jianfei Yun, Lishan Yang, Guangming Li, Bikram D Pant, Qingzhen Jiang, Kirankumar S Mysore

Journal: Nat Commun

PubMed ID: 35546550

Doi: 10.1038/s41467-022-30180-3

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The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNAPyl pairs in the same organism

Authors: Haolin Zhang, Xuemei Gong, Qianqian Zhao, Takahito Mukai, Oscar Vargas-Rodriguez, Huiming Zhang, Yuxing Zhang, Paul Wassel, Kazuaki Amikura, Julie Maupin-Furlow, Yan Ren, Xun Xu, Yuri I Wolf, Kira S Makarova, Eugene V Koonin, Yue Shen, Dieter Söll, Xian Fu

Journal: Nucleic Acids Res

PubMed ID: 35466371

Doi: 10.1093/nar/gkac271

Products & Services: Protein and Antibody Isolation

BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju

Journal: Mol Neurodegener

PubMed ID: 35526014

Doi: 10.1186/s13024-022-00535-x

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A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME

Authors: Xuejun Xiao, Yan Peng, Zheyue Wang, Louqian Zhang, Tingting Yang, Yangyang Sun, Yufeng Chen, Wenqing Zhang, Xinxia Chang, Wen Huang, Shuning Tian, Zhenqing Feng, Nabi Xinhua, Qi Tang, Yuan Mao

Journal: Pharmacol Res

PubMed ID: 35605813

Doi: 10.1016/j.phrs.2022.106269

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Plantaricin A, Derived from Lactiplantibacillus plantarum, Reduces the Intrinsic Resistance of Gram-Negative Bacteria to Hydrophobic Antibiotics

Authors: Fanqiang Meng, Yanan Liu, Ting Nie, Chao Tang, Fengxia Lyu, Xiaomei Bie, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: Appl Environ Microbiol

PubMed ID: 35499329

Doi: 10.1128/aem.00371-22

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Preclinical Assessment of IgY Antibodies Against Recombinant SARS-CoV-2 RBD Protein for Prophylaxis and Post-Infection Treatment of COVID-19

Authors: Andres Agurto-Arteaga, Astrid Poma-Acevedo, Dora Rios-Matos, Ricardo Choque-Guevara, Ricardo Montesinos-Millán, Ángela Montalván, Gisela Isasi-Rivas, Yudith Cauna-Orocollo, María de Grecia Cauti-Mendoza, Norma Pérez-Martínez, Kristel Gutierrez-Manchay, Ingrid Ramirez-Ortiz, Dennis Núñez-Fernández, Mario I Salguedo-Bohorquez, Stefany Quiñones-Garcia, Manolo Fernández Díaz, Luis A Guevara Sarmiento, Mirko Zimic

Journal: Front Immunol

PubMed ID: 35664008

Doi: 10.3389/fimmu.2022.881604

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Assessing four subdomain-specific affinity resins' capability to separate half-antibody from intact bispecific antibody

Authors: Wei Chen, Ting Zhang, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 35661701

Doi: 10.1016/j.pep.2022.106124

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Porcine ZC3H11A Is Essential for the Proliferation of Pseudorabies Virus and Porcine Circovirus 2

Authors: Lin Yang, Ziru Wang, Hongsheng Ouyang, Yuanzhu Zhang, Wenyu Xiao, Ying Liu, Jiacheng Deng, Mengjing Li, Lerong Ma, Chunyun Qi, Daxin Pang, Hongming Yuan

Journal: ACS Infect Dis

PubMed ID: 35559610

Doi: 10.1021/acsinfecdis.2c00150

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Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

Authors: Chinnu Rose Joseph, Sabrina Dusi, Michele Giannattasio, Dana Branzei

Journal: Nat Commun

PubMed ID: 35513396

Doi: 10.1038/s41467-022-30215-9

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Bioengineered miR-34a modulates mitochondrial inner membrane protein 17 like 2 (MPV17L2) expression toward the control of cancer cell mitochondrial functions

Authors: Wan-Rong Yi, Mei-Juan Tu, Ai-Xi Yu, Jun Lin, Ai-Ming Yu

Journal: Bioengineered

PubMed ID: 35579419

Doi: 10.1080/21655979.2022.2076399

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De Novo Arginine Synthesis Is Required for Full Virulence of pv During Walnut Bacterial Blight Disease

Authors: Cíntia H D Sagawa, Renata de A B Assis, Paulo A Zaini, Houston Saxe, Phillip A Wilmarth, Michelle Salemi, Brett S Phinney, Abhaya M Dandekar

Journal: Phytopathology

PubMed ID: 34941365

Doi: 10.1094/PHYTO-07-21-0302-R

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Green Tea Catechins, (-)-Catechin Gallate, and (-)-Gallocatechin Gallate are Potent Inhibitors of ABA-Induced Stomatal Closure

Authors: Kanane Sato, Shunya Saito, Kohsuke Endo, Masaru Kono, Taishin Kakei, Haruka Taketa, Megumi Kato, Shin Hamamoto, Matteo Grenzi, Alex Costa, Shintaro Munemasa, Yoshiyuki Murata, Yasuhiro Ishimaru, Nobuyuki Uozumi

Journal: Adv Sci (Weinh)

PubMed ID: 35524639

Doi: 10.1002/advs.202201403

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Depolarizing Na and hyperpolarizing K channels are co-trafficked in sensory neurons

Authors: Grant P Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, Elizabeth J Akin, Fadia B Dib-Hajj, Shujun Liu, Daniel Sosniak, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman

Journal: J Neurosci

PubMed ID: 35589395

Doi: 10.1523/JNEUROSCI.0058-22.2022

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Engineered SH2 Domains for Targeted Phosphoproteomics

Authors: Gregory D Martyn, Gianluca Veggiani, Ulrike Kusebauch, Seamus R Morrone, Bradley P Yates, Alex U Singer, Jiefei Tong, Noah Manczyk, Gerald Gish, Zhi Sun, Igor Kurinov, Frank Sicheri, Michael F Moran, Robert L Moritz, Sachdev S Sidhu

Journal: ACS Chem Biol

PubMed ID: 35613471

Doi: 10.1021/acschembio.2c00051

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Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients

Authors: Eva Schrezenmeier, Hector Rincon-Arevalo, Annika Jens, Ana-Luisa Stefanski, Charlotte Hammett, Bilgin Osmanodja, Nadine Koch, Bianca Zukunft, Julia Beck, Michael Oellerich, Vanessa Proß, Carolin Stahl, Mira Choi, Friederike Bachmann, Lutz Liefeldt, Petra Glander, Ekkehard Schütz, Kirsten Bornemann-Kolatzki, Covadonga López Del Moral, Hubert Schrezenmeier, Carolin Ludwig, Bernd Jahrsdörfer, Kai-Uwe Eckardt, Nils Lachmann, Katja Kotsch, Thomas Dörner, Fabian Halleck, Arne Sattler, Klemens Budde

Journal: JCI Insight

PubMed ID: 35349490

Doi: 10.1172/jci.insight.157836

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Structural and functional insights into the DNA damage-inducible protein 1 (Ddi1) from protozoa

Authors: Killivalavan Asaithambi, Iman Biswas, Kaza Suguna

Journal: Curr Res Struct Biol

PubMed ID: 35677776

Doi: 10.1016/j.crstbi.2022.05.003

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Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation

Authors: Narendran Annadurai, Lukáš Malina, Jakub Malohlava, Marián Hajdúch, Viswanath Das

Journal: Biochimie

PubMed ID: 35623497

Doi: 10.1016/j.biochi.2022.05.013

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The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy

Authors: Peter John, Marc C Pulanco, Phillip M Galbo, Yao Wei, Kim C Ohaegbulam, Deyou Zheng, Xingxing Zang

Journal: Nat Commun

PubMed ID: 35523809

Doi: 10.1038/s41467-022-30143-8

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Enhancement of Farnesoid X Receptor Inhibits Migration, Adhesion and Angiogenesis through Proteasome Degradation and VEGF Reduction in Bladder Cancers

Authors: Chien-Rui Lai, Hisao-Hsien Wang, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Chen-Ray Lee, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen

Journal: Int J Mol Sci

PubMed ID: 35563650

Doi: 10.3390/ijms23095259

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Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT

Authors: Sarah Heckmatt Shafik, Sashika Natasha Richards, Ben Corry, Rowena Elizabeth Martin

Journal: PLoS Biol

PubMed ID: 35507548

Doi: 10.1371/journal.pbio.3001616

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Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses

Authors: Jeeva Subbbiah, Judy Oh, Ki-Hye Kim, Chong Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Yu-Jin Jung, Youri Lee, Bao-Zhong Wang, Baik-Lin Seong, Sang-Moo Kang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35755946

Doi: 10.1016/j.omtm.2022.05.007

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Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain

Authors: Sucharita Sarkar, Brent Runge, Ryan W Russell, Kumar Tekwani Movellan, Daniel Calero, Somayeh Zeinalilathori, Caitlin M Quinn, Manman Lu, Guillermo Calero, Angela M Gronenborn, Tatyana Polenova

Journal: J Am Chem Soc

PubMed ID: 35638584

Doi: 10.1021/jacs.2c03320

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Expression and purification of the NG domain from human SRα, a key component of the Signal Recognition Particle (SRP) receptor

Authors: Madeline S McRae, Brendon Wang, RobertM G Hyson, Rezwan Siddiquee, Anthony P Duff, Sandro F Ataide, Ann H Kwan

Journal: Protein Expr Purif

PubMed ID: 35640773

Doi: 10.1016/j.pep.2022.106121

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Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding

Authors: Lucas R Struble, Audrey L Smith, William E Lutz, Gabrielle Grubbs, Satish Sagar, Kenneth W Bayles, Prakash Radhakrishnan, Surender Khurana, Dalia El-Gamal, Gloria E O Borgstahl

Journal: Protein Sci

PubMed ID: 35481636

Doi: 10.1002/pro.4300

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CARs-DB: A Database of Cryptic Amyloidogenic Regions in Intrinsically Disordered Proteins

Authors: Carlos Pintado-Grima, Oriol Bárcenas, Zoe Manglano-Artuñedo, Rita Vilaça, Sandra Macedo-Ribeiro, Irantzu Pallarès, Jaime Santos, Salvador Ventura

Journal: Front Mol Biosci

PubMed ID: 35898309

Doi: 10.3389/fmolb.2022.882160

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A vaccine targeting resistant tumours by dual T cell plus NK cell attack

Authors: Soumya Badrinath, Maxence O Dellacherie, Aileen Li, Shiwei Zheng, Xixi Zhang, Miguel Sobral, Jason W Pyrdol, Kathryn L Smith, Yuheng Lu, Sabrina Haag, Hamza Ijaz, Fawn Connor-Stroud, Tsuneyasu Kaisho, Glenn Dranoff, Guo-Cheng Yuan, David J Mooney, Kai W Wucherpfennig

Journal: Nature

PubMed ID: 35614223

Doi: 10.1038/s41586-022-04772-4

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Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis

Authors: Do Hoon Kwon, Feng Zhang, Justin G Fedor, Yang Suo, Seok-Yong Lee

Journal: Nat Commun

PubMed ID: 35610228

Doi: 10.1038/s41467-022-30602-2

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Rapid evolution and mechanism elucidation for efficient cellobiose-utilizing Saccharomyces cerevisiae through Synthetic Chromosome Rearrangement and Modification by LoxPsym-mediated Evolution

Authors: Yuwei Zhang, Zhaoxian Xu, Minrui Lu, Boning Ding, Sitong Chen, Zhiqiang Wen, Yang Yu, Linlin Zhou, Mingjie Jin

Journal: Bioresour Technol

PubMed ID: 35533888

Doi: 10.1016/j.biortech.2022.127268

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Evaluating blood-brain barrier disruption and infarction volume concurrently in rats subjected to ischemic stroke using an optical imaging system

Authors: Yao He, Yingqian Zhang, Wanxin Li, Qinxi Li, Bangcheng Zhao, Xun Tang, Daojun Chen, Ting Zhang, Tao Zhang, Zhihui Zhong

Journal: J Neurosci Methods

PubMed ID: 35613659

Doi: 10.1016/j.jneumeth.2022.109630

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Functionalization of a symmetric protein scaffold: Redundant folding nuclei and alternative oligomeric folding pathways

Authors: Connie A Tenorio, Joseph B Parker, Michael Blaber

Journal: Protein Sci

PubMed ID: 35481645

Doi: 10.1002/pro.4301

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The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

Authors: Andrew B Janowski, Hongbing Jiang, Chika Fujii, Macee C Owen, Traci L Bricker, Tamarand L Darling, Houda H Harastani, Kuljeet Seehra, Stephen Tahan, Ana Jung, Binita Febles, Joshua A Blatter, Scott A Handley, Bijal A Parikh, Valeria Lulla, Adrianus Cm Boon, David Wang

Journal: biorxiv

PubMed ID: 35547847

Doi: 10.1101/2022.04.30.486882

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Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling

Authors: Yao Gao, Liang Zhao, Jun Seok Son, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei-Jun Zhu, Gordon K Murdoch, Min Du

Journal: Thyroid

PubMed ID: 35286177

Doi: 10.1089/thy.2021.0639

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Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis

Authors: Andy Weiss, Caitlin C Murdoch, Katherine A Edmonds, Matthew R Jordan, Andrew J Monteith, Yasiru R Perera, Aslin M Rodríguez Nassif, Amber M Petoletti, William N Beavers, Matthew J Munneke, Sydney L Drury, Evan S Krystofiak, Kishore Thalluri, Hongwei Wu, Angela R S Kruse, Richard D DiMarchi, Richard M Caprioli, Jeffrey M Spraggins, Walter J Chazin, David P Giedroc, Eric P Skaar

Journal: Cell

PubMed ID: 35584702

Doi: 10.1016/j.cell.2022.04.011

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Circular RNA testis-expressed 14 overexpression induces apoptosis and suppresses migration of ox-LDL-stimulated vascular smooth muscle cells via regulating the microRNA 6509-3p/thanatos-associated domain-containing apoptosis-associated protein 1 axis

Authors: Lu Kou, Ning Yang, Bo Dong, Jingyu Yang, Yanqiu Song, Yang Li, Qin Qin

Journal: Bioengineered

PubMed ID: 35635088

Doi: 10.1080/21655979.2022.2070582

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Application of CRISPR/CasΦ2 System for Genome Editing in Plants

Authors: Qinan Cai, Dongmei Guo, Yujun Cao, Yuan Li, Rui Ma, Wenping Liu

Journal: Int J Mol Sci

PubMed ID: 35628563

Doi: 10.3390/ijms23105755

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Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 PPPY Motif

Authors: Xin Dong, Xianbin Zhang, Peng Liu, Yu Tian, Li Li, Peng Gong

Journal: Front Oncol

PubMed ID: 35586495

Doi: 10.3389/fonc.2022.896412

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Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling

Authors: Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E Biehn, Charles K Mobley, Monique J Rogals, Yoonkyoo Kim, Sushil K Mishra, Robert J Doerksen, Steffen Lindert, James H Prestegard, Joshua S Sharp

Journal: Commun Biol

PubMed ID: 35551273

Doi: 10.1038/s42003-022-03411-y

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Specific bio-functional CBD-PR1P peptide binding VEGF to collagen hydrogels promotes the recovery of cerebral ischemia in rats

Authors: Jia Yin, Chunying Shi, Wenli He, Wenjing Yan, Jin Deng, Bing Zhang, Mengmeng Yin, Haitao Pei, Haiping Wang

Journal: J Biomed Mater Res A

PubMed ID: 35603700

Doi: 10.1002/jbm.a.37409

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Structural basis for the synthesis of the core 1 structure by C1GalT1

Authors: Andrés Manuel González-Ramírez, Ana Sofia Grosso, Zhang Yang, Ismael Compañón, Helena Coelho, Yoshiki Narimatsu, Henrik Clausen, Filipa Marcelo, Francisco Corzana, Ramon Hurtado-Guerrero

Journal: Nat Commun

PubMed ID: 35504880

Doi: 10.1038/s41467-022-29833-0

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Characterization and clustering of kinase isoform expression in metastatic melanoma

Authors: David O Holland, Valer Gotea, Kevin Fedkenheuer, Sushil K Jaiswal, Catherine Baugher, Hua Tan, Michael Fedkenheuer, Laura Elnitski

Journal: PLoS Comput Biol

PubMed ID: 35560144

Doi: 10.1371/journal.pcbi.1010065

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Two Liberibacter Proteins Combine to Suppress Critical Innate Immune Defenses in Citrus

Authors: Supratim Basu, Loan Huynh, Shujian Zhang, Roel Rabara, Hau Nguyen, Jeanette Velásquez Guzmán, Guixia Hao, Godfrey Miles, Qingchun Shi, Ed Stover, Goutam Gupta

Journal: Front Plant Sci

PubMed ID: 35586217

Doi: 10.3389/fpls.2022.869178

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FastCAT Accelerates Absolute Quantification of Proteins Using Multiple Short Nonpurified Chimeric Standards

Authors: Ignacy Rzagalinski, Aliona Bogdanova, Bharath Kumar Raghuraman, Eric R Geertsma, Lena Hersemann, Tjalf Ziemssen, Andrej Shevchenko

Journal: J Proteome Res

PubMed ID: 35561006

Doi: 10.1021/acs.jproteome.2c00014

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Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/b-catenin signaling

Authors: Xiaowen Chen , Huishi Tan , Jie Xu , Yuan Tian , Qian Yuan , Yangyang Zuo , Qiyan Chen , Xue Hong , Haiyan Fu , Fan Fan Hou , Lili Zhou , Youhua Liu

Journal: Kidney Int

PubMed ID: 35644285

Doi: 10.1016/j.kint.2022.04.028

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Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Authors: Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire, Rienk Offringa, Claudia Gebhard, Rainer Spang, Michael Rehli, Michael Boutros, Christian Schmidl, Nisit Khandelwal, Philipp Beckhove

Journal: J Immunother Cancer

PubMed ID: 35606086

Doi: 10.1136/jitc-2021-004258

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SARS-CoV-2-mRNA Booster Vaccination Reverses Non-Responsiveness and Early Antibody Waning in Immunocompromised Patients - A Phase Four Study Comparing Immune Responses in Patients With Solid Cancers, Multiple Myeloma and Inflammatory Bowel Disease

Authors: Angelika Wagner, Erika Garner-Spitzer, Anna-Margarita Schötta, Maria Orola, Andrea Wessely, Ines Zwazl, Anna Ohradanova-Repic, Lukas Weseslindtner, Gabor Tajti, Laura Gebetsberger, Bernhard Kratzer, Elena Tomosel, Maximilian Kutschera, Selma Tobudic, Winfried F Pickl, Michael Kundi, Hannes Stockinger, Gottfried Novacek, Walter Reinisch, Christoph Zielinski, Ursula Wiedermann

Journal: Front Immunol

PubMed ID: 35634285

Doi: 10.3389/fimmu.2022.889138

Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA

Authors: Elin Karlsson, Jan Schnatwinkel, Cristina Paissoni, Eva Andersson, Christian Herrmann, Carlo Camilloni, Per Jemth

Journal: J Mol Biol

PubMed ID: 35605677

Doi: 10.1016/j.jmb.2022.167643

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A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

Authors: Inna Rozman Grinberg, Markel Martínez-Carranza, Ornella Bimai, Ghada Nouaïria, Saher Shahid, Daniel Lundin, Derek T Logan, Britt-Marie Sjöberg, Pål Stenmark

Journal: Nat Commun

PubMed ID: 35577776

Doi: 10.1038/s41467-022-30328-1

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Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaques

Authors: Nerea Zabaleta, Urja Bhatt, Cécile Hérate, Pauline Maisonnasse, Julio Sanmiguel, Cheikh Diop, Sofia Castore, Reynette Estelien, Dan Li, Nathalie Dereuddre-Bosquet, Mariangela Cavarelli, Anne-Sophie Gallouët, Quentin Pascal, Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Francis Relouzat, Giuseppe Ronzitti, Hendrik Jan Thibaut, Emanuele Montomoli, James M Wilson, Roger Le Grand, Luk H Vandenberghe

Journal: Mol Ther

PubMed ID: 35546782

Doi: 10.1016/j.ymthe.2022.05.007

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