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Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA

Authors: Fernando Rodriguez, Irina A Yushenova, Daniel DiCorpo, Irina R Arkhipova

Journal: Nat Commun

PubMed ID: 35228526

Doi: 10.1038/s41467-022-28471-w

Products & Services: Plasmid DNA Preparation

Grafting Watermelon Onto Pumpkin Increases Chilling Tolerance by Up Regulating to Increase Putrescine Biosynthesis

Authors: Junyang Lu, Fei Cheng, Yuan Huang, Zhilong Bie

Journal: Front Plant Sci

PubMed ID: 35242149

Doi: 10.3389/fpls.2021.812396

Products & Services: Molecular Biology Tools

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

Authors: Galen J Correy, Daniel W Kneller, Gwyndalyn Phillips, Swati Pant, Silvia Russi, Aina E Cohen, George Meigs, James M Holton, Stefan Gahbauer, Michael C Thompson, Alan Ashworth, Leighton Coates, Andrey Kovalevsky, Flora Meilleur, James S Fraser

Journal: biorxiv

PubMed ID: 35169801

Doi: 10.1101/2022.02.07.479477

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Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis

Authors: Albert Tsai, Justin Crocker

Journal: Development

PubMed ID: 35142344

Doi: 10.1242/dev.200266

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Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective cohort

Authors: Sakir Ahmed, Pankti Mehta, Aby Paul, S Anu, Somy Cherian, Veena Shenoy, Kaveri K Nalianda, Sanjana Joseph, Anagha Poulose, Padmanabha Shenoy

Journal: Ann Rheum Dis

PubMed ID: 35135831

Doi: 10.1136/annrheumdis-2021-221922

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Strategy for Conjugating Oligopeptides to Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers

Authors: Md Arif Khan, Ramy W Ghanim, Maelyn R Kiser, Mahsa Moradipour, Dennis T Rogers, John M Littleton, Luke H Bradley, Bert C Lynn, Stephen E Rankin, Barbara L Knutson

Journal: Nanomaterials (Basel)

PubMed ID: 35214937

Doi: 10.3390/nano12040608

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Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients

Authors: Jessica Bassi, Olivier Giannini, Chiara Silacci-Fregni, Laura Pertusini, Paolo Hitz, Tatiana Terrot, Yves Franzosi, Francesco Muoio, Christian Saliba, Marcel Meury, Exequiel A Dellota, Josh R Dillen, Patrick Hernandez, Nadine Czudnochowski, Elisabetta Cameroni, Nicola Beria, Mariangela Ventresca, Alberto Badellino, Soraya Lavorato-Hadjeres, Elisabetta Lecchi, Tecla Bonora, Matteo Mattiolo, Guido Trinci, Daniela Garzoni, Giuseppe Bonforte, Valentina Forni-Ogna, Davide Giunzioni, Lorenzo Berwert, Ravindra K Gupta, Paolo Ferrari, Alessandro Ceschi, Pietro Cippà, Davide Corti, Antonio Lanzavecchia, Luca Piccoli

Journal: PLoS ONE

PubMed ID: 35143540

Doi: 10.1371/journal.pone.0263328

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Phosphorylation of MdERF17 by MdMPK4 Promotes Apple Fruit Peel Degreening during Light/Dark Transitions

Authors: Shuai Wang, Ting Wang, Qiqi Li, Chen Xu, Ji Tian, Yi Wang, Xinzhong Zhang, Xuefeng Xu, Zhenhai Han, Ting Wu

Journal: Plant Cell

PubMed ID: 35166845

Doi: 10.1093/plcell/koac049

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Microsphere Peptide-Based Immunoassay for the Detection of Recombinant Bovine Somatotropin in Injection Preparations

Authors: Nathalie G E Smits, Toine F H Bovee, Sidharam P Pujari, Leendert A van Ginkel, Michel W F Nielen, Bauke Albada

Journal: Biosensors (Basel)

PubMed ID: 35323408

Doi: 10.3390/bios12030138

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Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus

Authors: Shikun Ge, Rao Wu, Tingting Zhou, Xiang Liu, Jin Zhu, Xiaoying Zhang

Journal: AMB Express

PubMed ID: 35150368

Doi: 10.1186/s13568-022-01355-4

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A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

Authors: M Gordon Joyce, Hannah A D King, Ines Elakhal-Naouar, Aslaa Ahmed, Kristina K Peachman, Camila Macedo Cincotta, Caroline Subra, Rita E Chen, Paul V Thomas, Wei-Hung Chen, Rajeshwer S Sankhala, Agnes Hajduczki, Elizabeth J Martinez, Caroline E Peterson, William C Chang, Misook Choe, Clayton Smith, Parker J Lee, Jarrett A Headley, Mekdi G Taddese, Hanne A Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James Brett Case, Jeffrey R Currier, Kerri G Lal, Sebastian Molnar, Manoj S Nair, Vincent Dussupt, Sharon P Daye, Xiankun Zeng, Erica K Barkei, Hilary M Staples, Kendra Alfson, Ricardo Carrion, Shelly J Krebs, Dominic Paquin-Proulx, Nicos Karasavva, Victoria R Polonis, Linda L Jagodzinski, Mihret F Amare, Sandhya Vasan, Paul T Scott, Yaoxing Huang, David D Ho, Natalia de Val, Michael S Diamond, Mark G Lewis, Mangala Rao, Gary R Matyas, Gregory D Gromowski, Sheila A Peel, Nelson L Michael, Diane L Bolton, Kayvon Modjarrad

Journal: Sci Transl Med

PubMed ID: 34914540

Doi: 10.1126/scitranslmed.abi5735

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Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

Authors: Yingying Wang, Xi Chen, Katharina Spengler, Karoline Terberger, Marko Boehm, Jens Appel, Thomas Barske, Stefan Timm, Natalia Battchikova, Martin Hagemann, Kirstin Gutekunst

Journal: Elife

PubMed ID: 35138247

Doi: 10.7554/eLife.71339

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Genome-edited powdery mildew resistance in wheat without growth penalties

Authors: Shengnan Li #, Dexing Lin # , Yunwei Zhang # , Min Deng # , Yongxing Chen , Bin Lv , Boshu Li , Yuan Lei , Yanpeng Wang , Long Zhao , Yueting Liang , Jinxing Liu , Kunling Chen , Zhiyong Liu , Jun Xiao , Jin-Long Qiu , Caixia Gao

Journal: Nature

PubMed ID: 35140403

Doi: 10.1038/s41586-022-04395-9

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Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase

Authors: Kaiwen Luo, Yaohui Chen, Fan Wang

Journal: J Immunol

PubMed ID: 35149533

Doi: 10.4049/jimmunol.2100595

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Effect of gastrointestinal alterations mimicking elderly conditions on in vitro digestion of meat and soy proteins

Authors: Chong Wang, Fan Zhao, Yun Bai, Chunbao Li, Xinglian Xu, Karsten Kristiansen, Guanghong Zhou

Journal: Food chemistry

Doi: 10.1016/j.foodchem.2022.132465

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p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Authors: Chao Ma, Yuhan Li, Yanan Zong, Tony Velkov, Chenxi Wang , Xinyu Yang , Ming Zhang, Zhimin Jiang, Haoran Sun, Qi Tong, Honglei Sun , Juan Pu, Munir Iqbal, Jinhua Liu , Chongshan Dai , Yipeng Sun

Journal: PLoS Pathog

PubMed ID: 35180274

Doi: 10.1371/journal.ppat.1010295

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LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

Authors: Rongze Ma , Difei Gong , Huanyang You , Chongshen Xu , Yunzhe Lu , Gabriele Bergers , Zena Werb , Ophir D Klein , Claudia K Petritsch , Pengfei Lu

Journal: Cell Rep

PubMed ID: 35172155

Doi: 10.1016/j.celrep.2022.110375

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Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

Authors: Jingwei Xu, Charles F Ericson, Yun-Wei Lien, Florentine U N Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165385

Doi: 10.1038/s41564-022-01059-2

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Characterization of gluten-degrading prolyl endoprotease from Thermococcus kodakarensis

Authors: Radhakrishna Shetty, Claus Heiner Bang-Berthelsen, Klaudia Weronika Ciurkot, Mike Vestergaard, Per Mårten Hägglund, Harishchandra S Prakash, Timothy John Hobley

Journal: FEMS Microbiol Lett

PubMed ID: 35038331

Doi: 10.1093/femsle/fnac006

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Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice

Authors: Lucía Pérez, Rui Alves, Laura Perez-Fons, Alfonso Albacete, Gemma Farré, Erika Soto, Ester Vilaprinyó, Cristina Martínez-Andújar, Oriol Basallo, Paul D Fraser, Vicente Medina, Changfu Zhu, Teresa Capell, Paul Christou

Journal: Transgenic Res

PubMed ID: 35201538

Doi: 10.1007/s11248-022-00299-6

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

Authors: Mingzhu Yang, Hanwen Yu, Xiu Yu, Shiqi Liang, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvák, Chuanbo Sun, Jichang Wang

Journal: Cell Stem Cell

PubMed ID: 35143761

Doi: 10.1016/j.stem.2022.01.010

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Expressing 2-keto acid pathway enzymes significantly increases photosynthetic isobutanol production

Authors: Hao Xie, Peter Lindblad

Journal: Microb Cell Fact

PubMed ID: 35105340

Doi: 10.1186/s12934-022-01738-z

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The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging

Authors: Yilin Ying, Xuefei Hu, Peng Han, Aaron Mendez-Bermudez, Serge Bauwens, Rita Eid, Li Tan, Mélanie Pousse, Marie-Joseph Giraud-Panis, Yiming Lu, Eric Gilson, Jing Ye

Journal: Nucleic Acids Res

PubMed ID: 35150283

Doi: 10.1093/nar/gkac065

Products & Services: Proteins, Expression, Isolation and Analysis

Immune Response of Adult Sickle Cell Disease Patients after COVID-19 Vaccination: The Experience of a Greek Center

Authors: Christos Varelas, Eleni Gavriilaki, Ioanna Sakellari, Philippos Klonizakis, Evaggelia-Evdoxia Koravou, Ioanna Christodoulou, Ioulia Mavrikou, Andreas Kourelis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Tasoula Touloumenidou, Apostolia Papalexandri, Achilles Anagnostopoulos, Efthimia Vlachaki

Journal: J Clin Med

PubMed ID: 35207208

Doi: 10.3390/jcm11040937

ATPase subunits of the 26S proteasome are important for oocyte maturation in the brown planthopper

Authors: Xu Cheng, Wei Wang, Lu Zhang, Rui-Rui Yang, Ya Ma, Yan-Yuan Bao

Journal: Insect Mol Biol

PubMed ID: 35084067

Doi: 10.1111/imb.12761

Products & Services: Proteins, Expression, Isolation and Analysis

PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner

Authors: Minghua Cao, Karol Nawalaniec, Amrendra K Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser

Journal: Transl Oncol

PubMed ID: 35196602

Doi: 10.1016/j.tranon.2022.101377

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The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory human intestinal model

Authors: Benthe van der Lugt, Maartje C P Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink, Wilma T Steegenga

Journal: Heliyon

PubMed ID: 35169646

Doi: 10.1016/j.heliyon.2022.e08883

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Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation

Authors: Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Journal: J Leukoc Biol

PubMed ID: 35188700

Doi: 10.1002/JLB.1MA0122-513R

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Aqueous Extract of Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Authors: Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu, Xuemei Sun

Journal: J Inflamm Res

PubMed ID: 35210810

Doi: 10.2147/JIR.S345497

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orter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Authors: Chan Zou, Jordan A Beard, Guoping Yang, William E Evans, Erik J Bonten

Journal: J Inflamm Res

PubMed ID: 35221708

Doi: 10.2147/JIR.S333725

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High density lipoprotein nanoparticle as delivery system for radio-sensitising miRNA: An investigation in 2D/3D head and neck cancer models

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Parisa Badiee, Benjamin Thierry

Journal: Int J Pharm

PubMed ID: 35176332

Doi: 10.1016/j.ijpharm.2022.121585

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A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds

Authors: Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu

Journal: Nanoscale

PubMed ID: 35167631

Doi: 10.1039/d1nr07452k

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

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Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma

Authors: Mengshang Xiong, Ruoqi Liu, Xiaomin Lei, Dongmei Fan, Fangzhen Lin, Wei Hao, Xiangfei Yuan, Yuanyuan Yang, Xiaolong Zhang, Zhou Ye, Yang Lu, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

Journal: J Immunother

PubMed ID: 34711791

Doi: 10.1097/CJI.0000000000000401

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Ligand-directed bias of G protein signaling at the dopamine D2 receptor

Authors: Ee Von Moo , Kasper Harpsøe , Alexander S Hauser , Ikuo Masuho , Hans Bräuner-Osborne , David E Gloriam , Kirill A Martemyanov

Journal: Cell Chem Biol .

PubMed ID: 34302750

Doi: 10.1016/j.chembiol.2021.07.004

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and evaluation of imatinib as an inhibitor for SARS-CoV-2

Authors: Nirmitee Mulgaonkar, Haoqi Wang, Samavath Mallawarachchi, Daniel Růžek, Byron Martina, Sandun Fernando

Journal: J Biomol Struct Dyn

PubMed ID: 35220926

Doi: 10.1080/07391102.2022.2045221

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Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Authors: Lingling Xu, Yinling Tan, Fengxia Xu, Yong Zhang

Journal: Bioengineered

PubMed ID: 35030964

Doi: 10.1080/21655979.2021.2019872

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membrane vesicles cause endothelial barrier failure and lung injury

Authors: Mark J McVey, Mazharul Maishan, Anna Foley, Razan Turki, Elyse J Roach, Rose Deschler, Sarah Weidenfeld, Neil M Goldenberg, Cezar M Khursigara, Wolfgang M Kuebler

Journal: Eur Respir J

PubMed ID: 35169027

Doi: 10.1183/13993003.01500-2021

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Vaccination Strategies at a COVID-19 Mass Vaccination Site

Authors: Sheng-Huang Hsiao, Sheng-Jean Huang, Chiao-Yu Huang

Journal: Int J Health Policy Manag

PubMed ID: 35247942

Doi: 10.34172/ijhpm.2022.6881

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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway

Authors: Jia Li, Zhao Xu

Journal: Mol Med Rep

PubMed ID: 35191517

Doi: 10.3892/mmr.2022.12649

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OmpA may be used as a novel target to enrich and detect Escherichia coli in milk samples

Authors: Yichen Tian, Kaiqing Yang, Yaoqiang Shi, Jinyang Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song

Journal: J Dairy Sci

PubMed ID: 35151480

Doi: 10.3168/jds.2021-20974

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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Sheng Luan, Dileep Vasudevan

Journal: Int J Biol Macromol

PubMed ID: 35218805

Doi: 10.1016/j.ijbiomac.2022.02.107

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis

Authors: Ana Cristina Medeiros-Ribeiro, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Henrique Carriço da Silva, Carla G S Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Carlo Scognamiglio Renner Araujo, Tatiane Lie Nakai, Clóvis Artur Silva, Tatiana Pedrosa, Léonard de Vinci Kanda Kupa, Matheus Santos Rodrigues Silva, Guilherme Guimarães Moreira Balbi, Esper Georges Kallas, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35135832

Doi: 10.1136/annrheumdis-2021-221735

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Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1

Authors: Yazhou Xiang, Yingjie Duan, Zhong Peng, Hong Huang, Wenjun Ding, En Chen, Zilong Liu, Chengyun Dou, Jianlong Li, Jihong Ou, Qingsong Wan, Bo Yang, Zhangxiu He

Journal: Calcif Tissue Int

PubMed ID: 35195734

Doi: 10.1007/s00223-022-00960-6

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Physiological ROS controls Upd3-dependent modeling of ECM to support cardiac function in

Authors: Jayati Gera, Prerna Budakoti, Meghna Suhag, Lolitika Mandal, Sudip Mandal

Journal: Sci Adv

PubMed ID: 35179958

Doi: 10.1126/sciadv.abj4991

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

Authors: Chi-Chuan Lin, Kin Man Suen, Polly-Anne Jeffrey, Lukasz Wieteska, Jessica A Lidster, Peng Bao, Alistair P Curd, Amy Stainthorp, Caroline Seiler, Hans Koss, Eric Miska, Zamal Ahmed, Stephen D Evans, Carmen Molina-París, John E Ladbury

Journal: Mol Cell

PubMed ID: 35231400

Doi: 10.1016/j.molcel.2022.02.005

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CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Authors: Yiru Long , Jianhua Sun , Tian-Zhang Song , Tingting Liu , Feng Tang , Xinxin Zhang, Longfei Ding , Yunqiu Miao , Weiliang Zhu , Xiaoyan Pan , Qi An, Mian Qin , Xiankun Tong , Xionghua Peng , Pan Yu, Peng Zhu , Jianqing Xu , Xiaoyan Zhang , Yachun Zhang , Datao Liu, Ben Chen , Huilin Chen , Leike Zhang , Gengfu Xiao, Jianping Zuo , Wei Tang , Ji Zhou, Heng Li , Zhijian Xu, Hong-Yi Zheng , Xin-Yan Long , Qiuping Qin , Yong Gan , Jin Ren , Wei Huang , Yong-Tang Zheng , Guangyi Jin , Likun Gong

Journal: Cell Discov .

PubMed ID: 35102138

Doi: 10.1038/s41421-021-00370-2

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Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects

Authors: Tzong-Shiann Ho, Pin-Xian Du, Wen-Yu Su, Harvey M Santos, Ya-Lan Lin, Yi-Yu Chou, Batuhan Birol Keskin, Chi Ho Pau, Guan-Da Syu

Journal: Biosens Bioelectron

PubMed ID: 35168024

Doi: 10.1016/j.bios.2022.114067

CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

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Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

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Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

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IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes

Authors: Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio

Journal: Front Cell Dev Biol

PubMed ID: 35186929

Doi: 10.3389/fcell.2022.814165

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IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy

Authors: Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D Kwong, Walther Mothes, Maolin Lu

Journal: MBio

PubMed ID: 35164561

Doi: 10.1128/mbio.03227-21

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Germinal centre-driven maturation of B cell response to mRNA vaccination

Authors: Wooseob Kim, Julian Q Zhou, Stephen C Horvath, Aaron J Schmitz, Alexandria J Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, Sean P J Whelan, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: Nature

PubMed ID: 35168246

Doi: 10.1038/s41586-022-04527-1

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Disentangling the recognition complexity of a protein hub using a nanopore

Authors: Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S Cosgrove, Aaron James Wolfe, Liviu Movileanu

Journal: Nat Commun

PubMed ID: 35190547

Doi: 10.1038/s41467-022-28465-8

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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Authors: Sheng-Han Kuo, Inmaculada Tasset, Melody M Cheng, Antonio Diaz, Ming-Kai Pan, Ori J Lieberman, Samantha J Hutten, Roy N Alcalay, Sangjun Kim, Pilar Ximénez-Embún, Li Fan, Donghoon Kim, Han Seok Ko, Talene Yacoubian, Ellen Kanter, Ling Liu, Guomei Tang, Javier Muñoz, Sergio Pablo Sardi, Aiqun Li, Li Gan, Ana Maria Cuervo, David Sulzer

Journal: Sci Adv

PubMed ID: 35138901

Doi: 10.1126/sciadv.abm6393

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Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes

Authors: Jean-Pierre Bikorimana, Jamilah Abusarah, Natasha Salame, Nehme El-Hachem, Riam Shammaa, Moutih Rafei

Journal: Cells

PubMed ID: 35203247

Doi: 10.3390/cells11040596

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CNOT6: A Novel Regulator of DNA Mismatch Repair

Authors: Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen

Journal: Cells

PubMed ID: 35159331

Doi: 10.3390/cells11030521

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mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

Authors: Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Journal: Life Sci Alliance

PubMed ID: 35169017

Doi: 10.26508/lsa.202201381

Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

Authors: Onofrio Valente, Raffaella Messina, Giuseppe Ingravallo, Emilio Bellitti, Domenico Sergio Zimatore, Luigi de Gennaro, Pasqua Abbrescia, Roberta Pati, Claudia Palazzo, Grazia Paola Nicchia, Maria Trojano, Francesco Signorelli, Antonio Frigeri

Journal: Cell Mol Life Sci

PubMed ID: 35187599

Doi: 10.1007/s00018-021-04123-y

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Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing

Authors: Xiaoxu Cui, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz

Journal: Virus Genes

PubMed ID: 35190939

Doi: 10.1007/s11262-022-01889-6

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Enzyme immunoassays (EIA) for serodiagnosis of human leptospirosis: specific IgG3/IgG1 isotyping may further inform diagnosis of acute disease

Authors: Elsa Fortes-Gabriel, Mariana Soares Guedes, Advait Shetty, Charles Klazer Gomes, Teresa Carreira, Maria Luísa Vieira, Lisa Esteves, Luísa Mota-Vieira, Maria Gomes-Solecki

Journal: PLoS Negl Trop Dis

PubMed ID: 35196321

Doi: 10.1371/journal.pntd.0010241

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Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins

Authors: Marina Pribanić Matešić, Paola Kučan Brlić, Tihana Lenac Roviš, Željka Mačak Šafranko, Abigael Eva Chaouat, Karmela Miklić, Suzana Malić, Nina Ivanković, Maren Schubert, Federico Bertoglio, Alemka Markotić, Ofer Mandelboim, Stipan Jonjić, Ilija Brizić

Journal: Viruses

PubMed ID: 35216036

Doi: 10.3390/v14020443

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Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene

Authors: Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M Larabee, Cinthia B Drachenberg, Harris Yfantis, Jean-Pierre Raufman

Journal: JCI Insight

PubMed ID: 35015732

Doi: 10.1172/jci.insight.150894

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The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines

Authors: Izabela Figiel, Ewa Bączyńska, Tomasz Wójtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Włodarczyk

Journal: Sci Rep

PubMed ID: 35169214

Doi: 10.1038/s41598-022-06462-7

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ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Authors: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian

Journal: J Exp Clin Cancer Res

PubMed ID: 35227287

Doi: 10.1186/s13046-022-02288-3

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Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Authors: Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh-Ichi Nagata

Journal: Cells

PubMed ID: 35203342

Doi: 10.3390/cells11040696

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Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active

Authors: Kayla Glockzin, Thomas D Meek, Ardala Katzfuss

Journal: PLoS Negl Trop Dis

PubMed ID: 35104286

Doi: 10.1371/journal.pntd.0009926

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Immunogenicity and safety of an intradermal fractional third dose of ChAdOx1 nCoV-19/AZD1222 vaccine compared with those of a standard intramuscular third dose in volunteers who previously received two doses of CoronaVac: A randomized controlled trial

Authors: Kriangkrai Tawinprai, Taweegrit Siripongboonsitti, Thachanun Porntharukchareon, Kasiruck Wittayasak, Nawarat Thonwirak, Kamonwan Soonklang, Gaidganok Sornsamdang, Chirayu Auewarakul, Nithi Mahanonda

Journal: Vaccine

PubMed ID: 35210118

Doi: 10.1016/j.vaccine.2022.02.019

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Authors: Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su

Journal: Nat Commun

PubMed ID: 35228542

Doi: 10.1038/s41467-022-28721-x

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Reduced α-galactosidase A activity in zebrafish ( mirrors distinct features of Fabry nephropathy phenotype

Authors: Hassan O A Elsaid, Jessica Furriol, Maria Blomqvist, Mette Diswall, Sabine Leh, Naouel Gharbi, Jan Haug Anonsen, Janka Babickova, Camilla Tøndel, Einar Svarstad, Hans-Peter Marti, Maximilian Krause

Journal: Mol Genet Metab Rep

PubMed ID: 35242583

Doi: 10.1016/j.ymgmr.2022.100851

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Characterization of a Group of UDP-Glycosyltransferases Involved in the Biosynthesis of Triterpenoid Saponins of

Authors: Yanting Li, Jianxiu Li, Mengxue Diao, Longyun Peng, Shihai Huang, Nengzhong Xie

Journal: ACS Synth Biol

PubMed ID: 35107265

Doi: 10.1021/acssynbio.1c00469

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miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level

Authors: Dapeng Wang, Jianbo Xiu, Jiangyue Zhao, Junli Luo

Journal: EMBO Rep

PubMed ID: 35201651

Doi: 10.15252/embr.202153691

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Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease

Authors: Ádám Diós, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R Korponay-Szabó

Journal: Int J Mol Sci

PubMed ID: 35269639

Doi: 10.3390/ijms23052498

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Poly(ADP-ribose) drives condensation of FUS via a transient interaction

Authors: Kevin Rhine, Morgan Dasovich, Joseph Yoniles, Mohsen Badiee, Sophie Skanchy, Laura R Ganser, Yingda Ge, Charlotte M Fare, James Shorter, Anthony K L Leung, Sua Myong

Journal: Mol Cell

PubMed ID: 35182479

Doi: 10.1016/j.molcel.2022.01.018

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Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer

Authors: Chao Zhang, Shuangqing Fu, Fanghua Zhang, Mengnan Han, Xuming Wang, Jie Du, Honglei Zhang, Wei Li

Journal: Nanomaterials (Basel)

PubMed ID: 35215023

Doi: 10.3390/nano12040696

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KIF18B promotes breast cancer cell proliferation, migration and invasion by targeting TRIP13 and activating the Wnt/β-catenin signaling pathway

Authors: Lan Liu, Zhaofeng Zhang, Xiulin Xia, Jing Lei

Journal: Oncol Lett

PubMed ID: 35251343

Doi: 10.3892/ol.2022.13232

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