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Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors: Olawale G Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M Lange, Cristian Polo Rivera, Tom D Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P M Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M K Muqit

Journal: SCIENCE ADVANCES

PubMed ID: 38848361

Doi: 10.1126/sciadv.adn7191

Products & Services: Proteins, Expression, Isolation and Analysis

Understanding the Phase Behavior of a Multistimuli-Responsive Elastin-like Polymer: Insights from Dynamic Light Scattering Analysis

Authors: Peter C Swanson, Galen P Arnold, Carolyn E Curley, Savannah C Wakita, Jeffery D V Waters, Eva Rose M Balog

Journal: J Phys Chem B

PubMed ID: 38830627

Doi: 10.1021/acs.jpcb.4c00070

Products & Services: Molecular Biology Reagents

Cholesterol neutralized vemurafenib treatment by promoting melanoma stem‑like cells via its metabolite 27‑hydroxycholesterol

Authors: Xiaohong Wang, Feiliang Zhong, Tingting Chen, Hongbo Wang, Weifang Wang, Hongkai Jin, Chouyang Li, Xuan Guo, Ying Liu, Yu Zhang, Bo Li

Journal: Cell Mol Life Sci

PubMed ID: 38775844

Doi: 10.1007/s00018-024-05267-3

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery

Authors: Maoyi Li, Nanhui Liu, Jiafei Zhu, Yumin Wu, Le Niu, Yi Liu, Linfu Chen, Boxiong Bai, Yu Miao, Yang Yang, Qian Chen

Journal: Biomaterials

PubMed ID: 38735180

Doi: doi.org/10.1016/j.biomaterials.2024.122584

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Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry

Authors: Sarah Fox, Antoine Gaudreau-LaPierre, Ryan Reshke, Irina Podinic, Derrick J Gibbings, Laura Trinkle-Mulcahy, John W Copeland

Journal: Int J Mol Sci

PubMed ID: 38891874

Doi: 10.3390/ijms25115686

Products & Services: Proteins, Expression, Isolation and Analysis

Blue light-mediated gene expression as a promising strategy to reduce antibiotic resistance in Escherichia coli

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Fengxia Lu, Libang Zhou

Journal: Biotechnol J

PubMed ID: 38719589

Doi: 10.1002/biot.202400023

Products & Services: Proteins, Expression, Isolation and Analysis

Effect of Free Cysteine Residues to Serine Mutation on Cellodextrin Phosphorylase

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: J Appl Glycosci (1999)

PubMed ID: 38863949

Doi: 10.5458/jag.jag.JAG-2023_0011

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Micro-and nano-plastics induce kidney damage and suppression of innate immune function in zebrafish (Danio rerio) larvae

Authors: Hui Yang, Jian Ju, Yuting Wang, Zhu Zhu, Wenyan Lu, Yingying Zhang

Journal: Sci Total Environ

PubMed ID: 38703841

Doi: 10.1016/j.scitotenv.2024.172952

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Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

Authors: Dan Gao, Wei-Wei Yi, Bo Liu, Cong-En Zhang, Cui-Cui Yang, Li Zeng, Lin Li, Guangbin Luo, Lan Zhang, Zhen-Yu Ju, Jia-Bo Wang

Journal: J Adv Res

PubMed ID: 38704089

Doi: 10.1016/j.jare.2024.04.027

Products & Services: Proteins, Expression, Isolation and Analysis

CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma

Authors: Lin Tan, Han Zhang, Yun Ding, Yangyun Huang, Daqiang Sun

Journal: Sci Rep

PubMed ID: 38755183

Doi: 10.1038/s41598-024-61804-x

Products & Services: Proteins, Expression, Isolation and Analysis

A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy

Authors: Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley

Journal: J Cell Biol

PubMed ID: 38728007

Doi: 10.1083/jcb.202309015

Products & Services: Molecular Biology Reagents

Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4

Authors: Jianyao Zeng, Yuan Fang, Zixuan Zhang, Zhenzhen Lv, Xiaodie Wang, Qian Huang, Zhidan Tian, Jiaguo Li, Wenfeng Xu, Weimin Zhu, Jing Yu, Tao Liu, Qijun Qian

Journal: Oncogene

PubMed ID: 38806619

Doi: 10.1038/s41388-024-03066-5

Products & Services: Proteins, Expression, Isolation and Analysis

Post-transcriptional regulation of the T-box gene midline via the 3'UTR in Drosophila is complex and cell and tissue-dependent

Authors: Kalpana Makhijani, Jordan Mar, Ivana Gaziova, Krishna Moorthi Bhat

Journal: Genetics

PubMed ID: 38805187

Doi: 10.1093/genetics/iyae087

Products & Services: Molecular Biology Reagents

Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids

Authors: Eduardo Reyes-Serratos, Joy Ramielle L Santos, Lakshmi Puttagunta, Stephen J Lewis, Mechiko Watanabe, Aron Gonshor, Robert Buck, A Dean Befus, Marcelo Marcet-Palacios

Journal: PLoS ONE

PubMed ID: 38753592

Doi: 10.1371/journal.pone.0301855

EDA2R knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway

Authors: Zhi-Hui Guan, Di Yang, Yi Wang, Jia-Bin Ma, Guo-Nian Wang

Journal: Exp Anim

PubMed ID: 38797667

Doi: 10.1538/expanim.24-0020

Products & Services: Molecular Biology Reagents

Filtered Saliva for Rapid and Accurate Analyte Detection for POC Diagnostics

Authors: Nadia Farsaeivahid, Christian Grenier, Ming L Wang

Journal: Diagnostics (Basel)

PubMed ID: 38893615

Doi: 10.3390/diagnostics14111088

Products & Services: Proteins, Expression, Isolation and Analysis

BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation

Authors: Swati Garg, Wei Ni, Basudev Chowdhury, Ellen L Weisberg, Martin Sattler, James D Griffin

Journal: Cell Death Differ

PubMed ID: 38816579

Doi: 10.1038/s41418-024-01306-5

Products & Services: Molecular Biology Reagents

L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase

Authors: Loredano Pollegioni, Barbara Campanini, Jean-Marc Good, Zoraide Motta, Giulia Murtas, Valeria Buoli Comani, Despina-Christina Pavlidou, Noëlle Mercier, Laureane Mittaz-Crettol, Silvia Sacchi, Francesco Marchesani

Journal: Sci Rep

PubMed ID: 38816452

Doi: 10.1038/s41598-024-63164-y

Products & Services: Proteins, Expression, Isolation and Analysis

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

Authors: Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G Seidah

Journal: Cells

PubMed ID: 38786080

Doi: 10.3390/cells13100857

Products & Services: Mutant Libraries

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy

Authors: Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera

Journal: J Immunother Cancer

PubMed ID: 38724462

Doi: 10.1136/jitc-2023-008104

Products & Services: Gene Synthesis

CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis

Authors: Jiaxin Chen, Huijuan Wang, Jianbin Xu, Engeng Chen, Qing Meng, Jiawei Wang, Haoyi Xiang, Wei Zhou, Ge Shan, Zhenyu Ju, Zhangfa Song

Journal: Sci China Life Sci

PubMed ID: 38805063

Doi: 10.1007/s11427-023-2514-y

Products & Services: Proteins, Expression, Isolation and Analysis

Construction of a grpE-based plasmid addiction system in Escherichia coli and its application in phloroglucinol biosynthesis

Authors: Ji-Ming Wang, Yu-Jin Cao, Xiao Men, Hai-Bo Zhang

Journal: J Appl Microbiol

PubMed ID: 38724452

Doi: 10.1093/jambio/lxae116

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of calcitonin gene-related peptide based on increased antigen-driven interaction with antibody variable regions

Authors: Yueqing Cheng, Yujie Gao, Shengshuo Zhang, Yujie Zou, Guangwei Zhao, Liyuan Zheng, Binghui Hou, Mei Li, Jinhua Dong

Journal: Front Bioeng Biotechnol

PubMed ID: 38882635

Doi: 10.3389/fbioe.2024.1395330

Products & Services: Molecular Biology Reagents

Glycan Profile and Sequence Variants of Certified Ricin Reference Material and Other Ricin Samples Yield Unique Molecular Signature Features

Authors: Roland Josuran, Andreas Wenger, Christian Müller, Bettina Kampa, Sylvia Worbs, Brigitte G Dorner, Sabina Gerber

Journal: Toxins (Basel)

PubMed ID: 38922138

Doi: 10.3390/toxins16060243

Products & Services: Proteins, Expression, Isolation and Analysis

TOP CAR with TMIGD2 as a safe and effective costimulatory domain in CAR cells treating human solid tumors

Authors: Christopher D Nishimura, Devin Corrigan, Xiang Yu Zheng, Phillip M Galbo, Shan Wang, Yao Liu, Yao Wei, Linna Suo, Wei Cui, Nadia Mercado, Deyou Zheng, Cheng Cheng Zhang, Xingxing Zang

Journal: Sci Adv

PubMed ID: 38718110

Doi: 10.1126/sciadv.adk1857

Products & Services: Proteins, Expression, Isolation and Analysis

HIV BG505 SOSIP664 trimer with 3M-052-AF/alum induces human autologous tier-2 neutralizing antibodies

Authors: William O Hahn, K Rachael Parks, Mingchao Shen, Gabriel Ozorowski, Holly Janes, Lamar Ballweber-Fleming, Amanda S Woodward Davis, Chris Duplessis, Mark Tomai, Antu K Dey, Zachary K Sagawa, Stephen C De Rosa, Aaron Seese, Latha Kallur Siddaramaiah, Leonidas Stamatatos, Wen-Hsin Lee, Leigh M Sewall, Dalton Karlinsey, Hannah L Turner, Vanessa Rubin, Sarah Furth, Kellie MacPhee, Michael Duff, Lawrence Corey, Michael C Keefer, Srilatha Edupuganti, Ian Frank, Janine Maenza, Lindsey R Baden, Ollivier Hyrien, Rogier W Sanders, John P Moore, Andrew B Ward, Georgia D Tomaras, David C Montefiori, Nadine Rouphael, M Juliana McElrath

Journal: medrxiv

PubMed ID: 38766048

Doi: 10.1101/2024.05.08.24306957

Products & Services: Monoclonal Antibody Services

The intrinsic substrate specificity of the human tyrosine kinome

Authors: Tomer M. Yaron-Barir, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari Sagum, Mark T. Bedford, R. Max Wynn, Shih-Chia Tso, David T. Chuang, Lei Li, Shawn S.-C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D. Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C. Frame, Peter V. Hornbeck, Lewis C. Cantley, Benjamin E. Turk, Michael B. Yaffe & Jared L. Johnson

Journal: Nature

PubMed ID: 38720073

Doi: 10.1038/s41586-024-07407-y

Products & Services: Codon Optimization

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

Authors: Hongjun Bai, Eric Lewitus, Yifan Li, Paul V. Thomas, Michelle Zemil, Mélanie Merbah, Caroline E. Peterson, Thujitha Thuraisamy, Phyllis A. Rees, Agnes Hajduczki, Vincent Dussupt, Bonnie Slike, Letzibeth Mendez-Rivera, Annika Schmid, Erin Kavusak, Mekhala Rao, Gabriel Smith, Jessica Frey, Alicea Sims, Lindsay Wieczorek, Victoria Polonis, Shelly J. Krebs, Julie A. Ake, Sandhya Vasan, Diane L. Bolton, M. Gordon Joyce, Samantha Townsley & Morgane Rolland

Journal: Nat Commun

PubMed ID: 38724518

Doi: 10.1038/s41467-024-48139-x

Products & Services: Gene Synthesis

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Authors: Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich & Dirk Schnappinger

Journal: Nat Commun

PubMed ID: 38755122

Doi: 10.1038/s41467-024-48448-1.

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Enhanced detection of ligand-PPARγ binding based on surface plasmon resonance through complexation with SRC1- or NCOR2-related polypeptide

Authors: Yiting Wang , Mingzhu Luo , Luyang Che , Qixin Wu , Jingzhe Li , Yanyan Ma , Jingyi Wang , Changzhen Liu

Journal: International Journal of Biological Macromolecules

PubMed ID: 38670200

Doi: 10.1016/j.ijbiomac.2024.131865

Products & Services: Gene Synthesis

A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries

Authors: Angele Bruce , Victor Adebomi , Patrick Czabala , Jonathan Palmer , William M McFadden , Zachary C Lorson , Ryan L Slack , Gaurav Bhardwaj , Stefan G Sarafianos , Monika Raj

Journal: Angew Chem Int Ed Engl

PubMed ID: 38529717

Doi: 10.1002/anie.202320045

Products & Services: PCR Cloning and Subcloning

Computer-Aided Semi-Rational Design to Enhance the Activity of l-Sorbosone Dehydrogenase from Gluconobacter oxidans WSH-004

Authors: Dong Li, Xinglong Wang, Lin Huo, Weizhu Zeng, Jianghua Li, Jingwen Zhou

Journal: J Agric Food Chem

PubMed ID: 38701424

Doi: 10.1021/acs.jafc.3c08365

Products & Services: Codon Optimization

ICG-labeled PD-L1-antagonistic affibody dimer for tumor imaging and enhancement of tumor photothermal-immunotherapy

Authors: Dianlong Jia, Shiqi Zhao, Huimin Liu, Xinyu Zhan, Zhongxia Zhou, Mingjia Lv, Xiufeng Tang, Wen Guo, Hui Li, Lilan Sun, Yidong Zhong, Baoqing Tian, Dandan Yuan, Xiaohui Tang, Qing Fan

Journal: Int J Biol Macromol

PubMed ID: 38704065

Doi: 10.1016/j.ijbiomac.2024.132058

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Ferritinophagy mediates adaptive resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer

Authors: Hui Wang, Qianfan Hu, Yuzhong Chen, Xing Huang, Yipeng Feng, Yuanjian Shi, Rutao Li, Xuewen Yin, Xuming Song, Yingkuan Liang, Te Zhang, Lin Xu, Gaochao Dong, Feng Jiang

Journal: Nat Commun

PubMed ID: 38760351

Doi: 10.1038/s41467-024-48433-8

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HIV-1 with gag processing defects activates cGAS sensing

Authors: Rebecca P Sumner, Henry Blest, Meiyin Lin, Carlos Maluquer de Motes, Greg J Towers

Journal: Retrovirology

PubMed ID: 38778414

Doi: 10.1186/s12977-024-00643-0

Products & Services: Molecular Biology Reagents

CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice

Authors: Henriette Reventlow Frederiksen, Alexandra Glantz, Kåre Kryger Vøls, Søren Skov, Pernille Tveden-Nyborg, Kristine Freude, Ulrik Doehn

Journal: Front Genome Ed

PubMed ID: 38863835

Doi: 10.3389/fgeed.2024.1403395

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Understanding the Enzyme ()-Norcoclaurine Synthase Promiscuity to Aldehydes and Ketones

Authors: Brunno A Salvatti, Marcelo A Chagas, Phillipe O Fernandes, Yan F X Ladeira, Aline S Bozzi, Veronica S Valadares, Ana Paula Valente, Amanda S de Miranda, Willian R Rocha, Vinicius G Maltarollo, Adolfo H Moraes

Journal: J Chem Inf Model

PubMed ID: 38776464

Doi: 10.1021/acs.jcim.3c01773

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Therapeutic potentials of nonpeptidic V2R agonists for partial cNDI-causing V2R mutants

Authors: Ritsuki Kuramoto, Ryoji Kise, Mayu Kanno, Kouki Kawakami, Tatsuya Ikuta, Noriko Makita, Asuka Inoue

Journal: PLoS ONE

PubMed ID: 38748623

Doi: 10.1371/journal.pone.0303507

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A systematic analysis of affinity tags in the haloarchaeal expression system, for protein purification

Authors: Ram Karan, Dominik Renn, Thorsten Allers, Magnus Rueping

Journal: Front Microbiol

PubMed ID: 38873150

Doi: 10.3389/fmicb.2024.1403623

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Preamplification-free ultra-fast and ultra-sensitive point-of-care testing via LwaCas13a

Authors: Wanting Zeng, Wanping Chen, Yang Liu, Ting Zhang, Chao Zhai, Wenqiang Li, Longyu Wang, Cheng Zhang, Qili Zeng, Fei Wang, Lixin Ma

Journal: Biosens Bioelectron

PubMed ID: 38776799

Doi: 10.1016/j.bios.2024.116400

Products & Services: Proteins, Expression, Isolation and Analysis

Design, Construction, and Validation of a Yeast-Displayed Chemically Expanded Antibody Library

Authors: Arlinda Rezhdo, Rebecca L Hershman, James A Van Deventer

Journal: biorxiv

PubMed ID: 38853888

Doi: 10.1101/2024.05.29.596443

Products & Services: Proteins, Expression, Isolation and Analysis

Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges

Authors: Bryce M Warner, Jacob G E Yates, Robert Vendramelli, Thang Truong, Courtney Meilleur, Lily Chan, Alexander Leacy, Phuc H Pham, Yanlong Pei, Leonardo Susta, Sarah K Wootton, Darwyn Kobasa

Journal: npj Vaccines

PubMed ID: 38782986

Doi: 10.1038/s41541-024-00870-8

Products & Services: Proteins, Expression, Isolation and Analysis

Development and characterization of an antibody that recognizes influenza virus N1 neuraminidases

Authors: Nan Chen, Renxi Wang, Wanlu Zhu, Xiangjun Hao, Jing Wang, Guojiang Chen, ChunXia Qiao, Xinying Li, Chenghua Liu, Beifen Shen, Jiannan Feng, Lihui Chai, Zuyin Yu, He Xiao

Journal: PLoS ONE

PubMed ID: 38723016

Doi: 10.1371/journal.pone.0302865

Products & Services: Proteins, Expression, Isolation and Analysis

Temperature-dependent iron motion in extremophile rubredoxins - no need for 'corresponding states'

Authors: Francis E Jenney, Hongxin Wang, Simon J George, Jin Xiong, Yisong Guo, Leland B Gee, Juan José Marizcurrena, Susana Castro-Sowinski, Anna Staskiewicz, Yoshitaka Yoda, Michael Y Hu, Kenji Tamasaku, Nobumoto Nagasawa, Lei Li, Hiroaki Matsuura, Tzanko Doukov, Stephen P Cramer

Journal: Sci Rep

PubMed ID: 38806591

Doi: 10.1038/s41598-024-62261-2

Products & Services: Proteins, Expression, Isolation and Analysis

Stacked mutations in wheat homologues of rice SEMI-DWARF1 confer a novel semi-dwarf phenotype

Authors: Barbora Ndreca, Alison Huttly, Sajida Bibi, Carlos Bayon, George Lund, Joshua Ham, Rocío Alarcón-Reverte, John Addy, Danuše Tarkowská, Stephen Pearce, Peter Hedden, Stephen G Thomas, Andrew L Phillips

Journal: BMC Plant Biol

PubMed ID: 38724935

Doi: 10.1186/s12870-024-05098-1

Products & Services: Mutant Libraries

Accuracy of Anti-SARS-CoV-2 Antibody in Comparison with Surrogate Viral Neutralization Test in Persons Living with HIV, Systemic Lupus Erythematosus, and Chronic Kidney Disease

Authors: Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Journal: Vaccines (Basel)

PubMed ID: 38793809

Doi: 10.3390/vaccines12050558

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Acts as a Positive Regulator of Secondary Cell Wall Synthesis in Sudan Grass ( S)

Authors: Yanzhong Huang, Juanzi Wu, Jianyu Lin, Zhiwei Liu, Zhengfeng Mao, Chen Qian, Xiaoxian Zhong

Journal: Plants (Basel)

PubMed ID: 38794423

Doi: 10.3390/plants13101352

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Development and validation of an HILIC/MS/MS method for determination of nusinersen in rabbit plasma

Authors: Xiao Zhang, Chunjie Sha, Wei Zhang, Fengjuan Zhao, Mingli Zhu, Guangyi Leng, Wanhui Liu

Journal: Heliyon

PubMed ID: 38799737

Doi: 10.1016/j.heliyon.2024.e31213

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Effect of three oral pathogens on the TMA-TMAO metabolic pathway

Authors: Xixuan Wang, Liyuan Chen, Ye Teng, Weige Xie, Lingyan Huang, Juan Wu, Hongwei Wang, Sijing Xie

Journal: Front Cell Infect Microbiol

PubMed ID: 38836053

Doi: 10.3389/fcimb.2024.1413787

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4-Octyl Itaconate Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis Via Regulating Microglia

Authors: Ning Zhao, Ming Yi, Lin-Jie Zhang, Qiu-Xia Zhang, Li Yang

Journal: Inflammation

PubMed ID: 38761250

Doi: 10.1007/s10753-024-02050-1

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Design of antiviral AGO2-dependent short hairpin RNAs

Authors: Yuanyuan Bie, Jieling Zhang, Jiyao Chen, Yumin Zhang, Muhan Huang, Leike Zhang, Xi Zhou, Yang Qiu

Journal: Virol Sin

PubMed ID: 38734183

Doi: 10.1016/j.virs.2024.05.001

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The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a model of Parkinson's disease

Authors: Shuanglong Yi, Linfang Wang, Margaret S Ho, Shiping Zhang

Journal: Neural Regen Res

PubMed ID: 37862221

Doi: 10.4103/1673-5374.382259

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Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma

Authors: Feng-Lin Dong, Zong-Zhen Xu, Ying-Qiao Wang, Tao Li, Xin Wang, Jie Li

Journal: J Nanobiotechnology

PubMed ID: 38811968

Doi: 10.1186/s12951-024-02582-6

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Graph-Based Pangenome of Actinidia chinensis Reveals Structural Variations Mediating Fruit Degreening

Authors: Yingzhen Wang, Pengwei Li, Yanyan Zhu, Feng Zhang, Sijia Zhang, Yan He, Ying Wu, Yunzhi Lin, Hongtao Wang, Wangmei Ren, Lihuan Wang, Ying Yang, Runze Wang, Pengpeng Zheng, Yongsheng Liu, Songhu Wang, Junyang Yue

Journal: Adv Sci (Weinh)

PubMed ID: 38757662

Doi: 10.1002/advs.202400322

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Construction and immune effect evaluation of the S protein heptad repeat-based nanoparticle vaccine against porcine epidemic diarrhea virus

Authors: Dan Yang, Xinglin Wang, Xu Yang, Shanshan Qi, Feiyu Zhao, Donghua Guo, Chunqiu Li, Qinghe Zhu, Xiaoxu Xing, Yang Cao, Dongbo Sun

Journal: Virology

PubMed ID: 38801794

Doi: 10.1016/j.virol.2024.110113

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An Active and Versatile Electron Transport System for Cytochrome P450 Monooxygenases from the Alkane Degrading Organism Acinetobacter sp OC4

Authors: Fabian Peter Josef Schultes, Leon Welter, Doreen Hufnagel, Melanie Heghmanns, Müge Kasanmascheff, Carolin Muegge

Journal: Chembiochem

PubMed ID: 38787654

Doi: 10.1002/cbic.202400098

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The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner

Authors: Wannapa Sornjai, Ploenphit Promma, Suphansa Priewkhiew, Suwipa Ramphan, Janejira Jaratsittisin, Pailin Jinagool, Nitwara Wikan, Michael Greenwood, David Murphy, Duncan R Smith

Journal: Sci Rep

PubMed ID: 38710792

Doi: 10.1038/s41598-024-61195-z

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Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors

Authors: Hongjin Zhang, Guohao Lin, Suyun Jia, Jianbo Wu, Ying Zhang, Yanxin Tao, Weixue Huang, Meiru Song, Ke Ding, Dawei Ma, Mengyang Fan

Journal: Bioorg Chem

PubMed ID: 38761706

Doi: 10.1016/j.bioorg.2024.107456

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Kanglexin counters vascular smooth muscle cell dedifferentiation and associated arteriosclerosis through inhibiting PDGFR

Authors: Shuang Yang, Yixiu Zhao, Shifeng Cao, Xinxin Liu, Min Feng, Yi Chen, Chunyue Ma, Tingting Zhan, Qi Zhang, Honglin Jia, Yu Zhao, Ming Tong, Yuanyuan Yu, Xue Liu, Baofeng Yang, Yan Zhang

Journal: Phytomedicine

PubMed ID: 38759316

Doi: 10.1016/j.phymed.2024.155704

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Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16

Authors: Kejue Wu, Yinfeng Guo, Tiefeng Xu, Weifeng Huang, Deyin Guo, Liu Cao, Jinping Lei

Journal: Molecules

PubMed ID: 38792173

Doi: 10.3390/molecules29102312

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Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete,

Authors: Michael J Rudolph, Yang Chen, Clint Vorauer, David J Vance, Carol Lyn Piazza, Graham G Willsey, Kathleen McCarthy, Beatrice Muriuki, Lisa A Cavacini, Miklos Guttman, Nicholas J Mantis

Journal: biorxiv

PubMed ID: 38746285

Doi: 10.1101/2024.04.29.591597

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N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma

Authors: Alex Miranda, Swetansu Pattnaik, Phineas T Hamilton, Monica Alvaro Fuss, Shreena Kalaria, Céline M Laumont, Julian Smazynski, Monica Mesa, Allyson Banville, Xinpei Jiang, Russell Jenkins, Israel Cañadas, Brad H Nelson

Journal: Sci Adv

PubMed ID: 38748789

Doi: 10.1126/sciadv.adj5428

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Development of novel monoclonal antibodies for blocking NF-κB activation induced by CD2v protein in African swine fever virus

Authors: Rongrong Fan, Zeliang Wei, Mengmeng Zhang, Shanshan Jia, Zhiyang Jiang, Yao Wang, Junyu Cai, Guojiang Chen, He Xiao, Yinxiang Wei, Yanchun Shi, Jiannan Feng, Beifen Shen, Yuanqiang Zheng, Yaojiang Huang, Jing Wang

Journal: Front Immunol

PubMed ID: 38846950

Doi: 10.3389/fimmu.2024.1352404

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Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry

Authors: Junshi Yazaki, Takashi Yamanashi, Shino Nemoto, Atsuo Kobayashi, Yong-Woon Han, Tomoko Hasegawa, Akira Iwase, Masaki Ishikawa, Ryo Konno, Koshi Imami, Yusuke Kawashima, Jun Seita

Journal: Biol Methods Protoc

PubMed ID: 38884001

Doi: 10.1093/biomethods/bpae039

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Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate

Authors: Venkadesh Sarkarai Nadar, Kunie Yoshinaga-Sakurai, Barry P Rosen

Journal: Organometallics

PubMed ID: 38817537

Doi: 10.1021/acs.organomet.4c00082

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A Novel Fluorescence-Based Microplate Assay for High-Throughput Screening of hSULT1As Inhibitors

Authors: Xiaoting Niu, Yufan Fan, Liwei Zou, Guangbo Ge

Journal: Biosensors (Basel)

PubMed ID: 38920579

Doi: 10.3390/bios14060275

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Structural basis for double-stranded RNA recognition by SID1

Authors: Runhao Wang, Ye Cong, Dandan Qian, Chuangye Yan, Deshun Gong

Journal: Nucleic Acids Res

PubMed ID: 38742627

Doi: 10.1093/nar/gkae395

Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

Authors: Di Yin # 1, Yiye Zhong # 1, Sikai Ling # 1 2, Sicong Lu # 1, Xiaoyuan Wang # 2, Zhuofan Jiang 1, Jie Wang 1, Yao Dai 1, Xiaolong Tian 3, Qijing Huang 1, Xingbo Wang 4, Junsong Chen 1, Ziying Li 1, Yang Li 1, Zhijue Xu 1, Hewei Jiang 1, Yuqing Wu 5, Yi Shi 6, Quanjun Wang 7, Jianjiang Xu 5, Wei Hong 8 9, Heng Xue 8 9, Hang Yang 8 9 10, Yan Zhang 1, Lintai Da 1, Ze-Guang Han 1, Sheng-Ce Tao 1, Ruijiao Dong 1, Tianlei Ying 3, Jiaxu Hong 11, Yujia Cai 12

Journal: Nat Biomed Eng

PubMed ID: 38714892

Doi: 10.1038/s41551-024-01208-4

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Interaction between Chromodomain Y-like Protein and Androgen Receptor Signaling in Sertoli Cells Accounts for Spermatogenesis

Authors: Kuo-Chung Lan, Yin-Hua Cheng, Yun-Chiao Chang, Kuo-Ting Wei, Pei-Ling Weng, Hong-Yo Kang

Journal: Cells

PubMed ID: 38786072

Doi: 10.3390/cells13100851

Products & Services: Proteins, Expression, Isolation and Analysis

Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Authors: Zhe Li, Zhi-Min Xu, Wei-Peng Chen, Xiao-Jing Du, Chun-Xian Ou, Zi-Kang Luo, Rong Wang, Chu-Qing Zhang, Chao-Dong Ge, Meng Han, Fudi Wang, Rong-Rong He, Wan-Yang Sun, Jun Ma, Xiao-Yu Liang, Zhuo-Wei Liu

Journal: Nat Chem Biol

PubMed ID: 38720107

Doi: 10.1038/s41589-024-01612-6

Products & Services: Proteins, Expression, Isolation and Analysis

Outer membrane vesicles generated by an exogenous bacteriophage lysin and protection against Acinetobacter baumannii infection

Authors: Changchang Li, Heng Xue, Xinjing Du, Raphael Nyaruaba, Hang Yang, Hongping Wei

Journal: J Nanobiotechnology

PubMed ID: 38773507

Doi: 10.1186/s12951-024-02553-x

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The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

Authors: Xiaolei Huang, Cheng Zhang, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, Shaoming Shen, Yanli Liu

Journal: Cell Death Dis

PubMed ID: 38744853

Doi: 10.1038/s41419-024-06714-6

Products & Services: Proteins, Expression, Isolation and Analysis

Improvement of tumor neoantigen detection by high field asymmetric waveform ion mobility mass spectrometry

Authors: Wei Meng, Yoshiko Takeuchi, Jeffrey P Ward, Hussein Sultan, Cora D Arthur, Elaine R Mardis, Maxim N Artyomov, Cheryl F Lichti, Robert D Schreiber

Journal: Cancer Immunol Res

PubMed ID: 38768391

Doi: 10.1158/2326-6066.CIR-23-0900

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Curing of a field strain of Salmonella enterica serovar Infantis isolated from poultry from its highly stable pESI like plasmid

Authors: Nadya Gruzdev, Chen Katz, Itamar Yadid

Journal: J Microbiol Methods

PubMed ID: 38782300

Doi: 10.1016/j.mimet.2024.106959

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CaptureSelect FcXP affinity medium exhibits strong aggregate separation capability

Authors: Wanyuan Dong, Dan Zhang, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 38759705

Doi: 10.1016/j.pep.2024.106503

Products & Services: Proteins, Expression, Isolation and Analysis

Kaposi sarcoma-associated herpesvirus complement control protein (KCP) and glycoprotein K81 are not required for viral infection or

Authors: Murali Muniraju, Lorraine Z Mutsvunguma, Ivana G Reidel, Gabriela M Escalante, Simeon Cua, Webster Musonda, Jonathan Calero-Landa, Mafalda A Farelo, Esther Rodriguez, Zhou Li, Javier Gordon Ogembo

Journal: J Virol

PubMed ID: 38767375

Doi: 10.1128/jvi.00576-24

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant chimeric antigen constructed with B-cell epitopes from Mycobacterium leprae hypothetical proteins is effective for the diagnosis of leprosy

Authors: Bárbara P N Assis, Ana T Chaves, Daniela P Lage, Mariana M Cardoso, Isabela A G Pereira, Raquel S B Câmara, Camila S Freitas, Vívian T Martins, Fernanda Ludolf, Ana Laura G de Oliveira, João A Oliveira-da-Silva, Grasiele S V Tavares, Alexsandro S Galdino, Miguel A Chávez-Fumagalli, Ricardo A Machado-de-Ávila, Myron Christodoulides, Denise U Gonçalves, Lílian L Bueno, Ricardo T Fujiwara, Eduardo A F Coelho, Manoel Otávio da Costa Rocha

Journal: Diagn Microbiol Infect Dis

PubMed ID: 38718661

Doi: 10.1016/j.diagmicrobio.2024.116338

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Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

Authors: Alexandra Houser, Isabelle Baconguis

Journal: biorxiv

PubMed ID: 38853903

Doi: 10.1101/2024.05.28.595834

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Effective Control of Sclerotinia Stem Rot in Canola Plants Through Application of Exogenous Hairpin RNA of Multiple Genes

Authors: Abdolbaset Azizi, Luis E Del Río Mendoza

Journal: Phytopathology

PubMed ID: 38506733

Doi: 10.1094/PHYTO-10-23-0395-KC

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Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones

Authors: Jennifer A Smith, Benjamin T K Yuen, Whitney Purtha, Jared M Balolong, Jonah D Phipps, Frances Crawford, Jeffrey A Bluestone, John W Kappler, Mark S Anderson

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38709934

Doi: 10.1073/pnas.2320268121

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Type IX Collagen Turnover Is Altered in Patients with Solid Tumors

Authors: Helena Port, Yi He, Morten A Karsdal, Emilie A Madsen, Anne-Christine Bay-Jensen, Nicholas Willumsen, Signe Holm Nielsen

Journal: Cancers (Basel)

PubMed ID: 38893155

Doi: 10.3390/cancers16112035

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Biochemical synthesis of taxanes from mevalonate

Authors: Jing Li, Xiaonan Liu, Xiaoxi Zhu, Jiayu Liu, Lei Zhang, Nida Ahmed, Jian Qi, Bihuan Chen, Daliang Tang, Jinsheng Yu, Zhijin Fan, Huifeng Jiang

Journal: Synth Syst Biotechnol

PubMed ID: 38868609

Doi: 10.1016/j.synbio.2024.05.002

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Dimerization and antidepressant recognition at noradrenaline transporter

Authors: Heng Zhang # 1, Yu-Ling Yin # 2, Antao Dai # 3 4, Tianwei Zhang 2 5, Chao Zhang 4 6, Canrong Wu 1, Wen Hu 1 7, Xinheng He 1 8, Benxun Pan 2, Sanshan Jin 2, Qingning Yuan 1 7, Ming-Wei Wang 9 10 11, Dehua Yang 12 13 14, H Eric Xu 15 16 17, Yi Jiang 18 19

Journal: Nature

PubMed ID: 38750358

Doi: 10.1038/s41586-024-07437-6.

Products & Services: Proteins, Expression, Isolation and Analysis

Biochemical characterization of a novel thermostable ulvan lyase from Tamlana fucoidanivorans CW2-9

Authors: Yan Xu, Jin Li, Lu An, Yuankai Qiu, Aihua Mao, Zhixiao He, Jialing Guo, Hanbing Yan, Han Li, Zhong Hu

Journal: J Agric Food Chem

PubMed ID: 38722333

Doi: 10.1021/acs.jafc.4c01717

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UV-Inactivated rVSV-M2e-Based Influenza Vaccine Protected against the H1N1 Influenza Challenge

Authors: Titus Abiola Olukitibi, Zhujun Ao, Hiva Azizi, Maggie J Ouyang, Tosin Omole, Lyle McKinnon, Darwyn Kobasa, Kevin Coombs, Gary Kobinger, Xiaojian Yao

Journal: Front Biosci (Landmark Ed)

PubMed ID: 38812326

Doi: 10.31083/j.fbl2905195

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Localizing Protein Expression of Transporters in Epithelial Cell Membranes of Mosquitoes

Authors: Andrea C Durant, Andrew Donini

Journal: Cold Spring Harb Protoc

PubMed ID: 37648374

Doi: 10.1101/pdb.prot108326

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Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin

Authors: Huihui Hong, Jingdian Li, Tong Tong, Ting Yang, Hui Wang, Yudong Xu, Xiqin Lin, Jinxian Lin, Sicheng Liu, Kun Luo, Zhengping Yu, Wei Yuan, Huifeng Pi, Zhou Zhou

Journal: Sci Total Environ

PubMed ID: 38750743

Doi: 10.1016/j.scitotenv.2024.173119

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Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid

Authors: Yi-Ke Qi, Jiang Pan, Zhi-Jun Zhang, Jian-He Xu

Journal: Bioresour Bioprocess

PubMed ID: 38780695

Doi: 10.1186/s40643-024-00770-8

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COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection

Authors: Aniza P Mahyuddin, Hannah L F Swa, Ruifen Weng, Jingxian Zhang, Janice P Dhanaraj, Binny P Sesurajan, Mary Rauff, Pradip Dashraath, Abhiram Kanneganti, Rachel Lee, Lin-Fa Wang, Barnaby E Young, Paul A Tambyah, David C Lye, Louis Y A Chai, Sidney Yee, Mahesh Choolani, Citra N Z Mattar

Journal: Int J Infect Dis

PubMed ID: 38823622

Doi: 10.1016/j.ijid.2024.107121

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Engineered coiled-coil HIF1α protein domain mimic

Authors: Dustin Britton, Olga Katsara, Orin Mishkit, Andrew Wang, Neelam Pandya, Chengliang Liu, Heather Mao, Jakub Legocki, Sihan Jia, Yingxin Xiao, Orlando Aristizabal, Deven Paul, Yan Deng, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: Biomater Sci

PubMed ID: 38656316

Doi: 10.1039/d4bm00354c

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CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

Authors: Ali M Nasser, Lisa Melamed, Ethan Wetzel, Chia-Chen Chang, Hiroaki Nagashima, Yosuke Kitagawa, Logan Muzyka, Hiroaki Wakimoto, Daniel P Cahill, Julie J Miller

Journal: Clin Cancer Res

PubMed ID: 38718141

Doi: 10.1158/1078-0432.CCR-24-0562

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HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice

Authors: Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: Cell Death Dis

PubMed ID: 38744826

Doi: 10.1038/s41419-024-06716-4

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Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop

Authors: Rongze Ma, Deyi Feng, Jing Chen, Jiecan Zhou, Kun Xia, Xiangyin Kong, Guohong Hu, Pengfei Lu

Journal: Adv Sci (Weinh)

PubMed ID: 38708713

Doi: doi.org/10.1002/advs.202307452

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Exploring roles of the chitinase ChiC in modulating virulence phenotypes

Authors: Per Kristian Thorén Edvardsen, Fatemeh Askarian, Raymond Zurich, Victor Nizet, Gustav Vaaje-Kolstad

Journal: Microbiol Spectr

PubMed ID: 38819151

Doi: 10.1128/spectrum.00546-24

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PKD2 regulates autophagy and forms a protein complex with BECN1 at the primary cilium of hypothalamic neuronal cells

Authors: Camila García-Navarrete, Catalina Kretschmar, Jorge Toledo, Karla Gutiérrez, María Paz Hernández-Cáceres, Mauricio Budini, Valentina Parra, Patricia V Burgos, Sergio Lavandero, Eugenia Morselli, Daniel Peña-Oyarzún, Alfredo Criollo

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38782303

Doi: 10.1016/j.bbadis.2024.167256

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Generation and application of immortalized sheep fetal fibroblast cell line

Authors: Guoyu Du, Cheng Zhang, Xiaoan Cao, Lingxia Li, Yong Zhang, Youjun Shang, Jinyan Wu

Journal: BMC Vet Res

PubMed ID: 38745180

Doi: 10.1186/s12917-024-04054-3

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Targeted Clearance of Senescent Cells Via Engineered Extracellular Vesicles Reprograms Tumor Immunosuppressive Microenvironment

Authors: Panpan Ji, Chen Wang, Yang Liu, Xin Guo, Yuan Liang, Jiangpeng Wei, Zhaoyou Liu, Li Gong, Guodong Yang, Gang Ji

Journal: Adv Healthc Mater

PubMed ID: 38794820

Doi: 10.1002/adhm.202400945

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Mucosal vaccination in a murine gnotobiotic model of infection

Authors: Sozaburo Ihara, Brian V Nguyen, Yukiko Miyamoto, Lars Eckmann

Journal: Infect Immun

PubMed ID: 38722167

Doi: 10.1128/iai.00065-24

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Retinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD

Authors: M Akula, S M McNamee, Z Love, N Nasraty, N P M Chan, M Whalen, M O Avola, A M Olivares, B D Leehy, A S Jelcick, P Singh, A K Upadhyay, D F Chen, N B Haider

Journal: Gene Ther

PubMed ID: 38755404

Doi: 10.1038/s41434-024-00455-z

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A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice

Authors: Dujuan Li, Yuxin Lu, Fengjun Xiao, Xiaochen Cheng, Chunsheng Hu, Xuefeng Zhu, Xiaoying Wang, Haiying Duan, Li Du, Qinglin Zhang

Journal: J Radiat Res

PubMed ID: 38682896

Doi: 10.1093/jrr/rrae011

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