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SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Journal: Vaccines (Basel)

PubMed ID: 38932392

Doi: 10.3390/vaccines12060663

Products & Services: Molecular Biology Reagents

Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse

Authors: Aoxiang Wang, Jinxi Zhou, Yiwen Hong, Yamei Cui, Yishen Wang, Jianying Pan, Yue Wu, Yan Luo

Journal: Ophthalmic Res

PubMed ID: 38857592

Doi: 10.1159/000539605

Products & Services: Proteins, Expression, Isolation and Analysis

Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice NF-κb-signaling pathway

Authors: Tao-Lin Qing, Xuan-Yao Jiang, Jin-Feng Li, Qi Shen, Xin-Yi Zhao, Li-Jun Ren, Xiao-Yu Dai, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Bin Zhang, Lang Yan, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Inhal Toxicol

PubMed ID: 38836332

Doi: 10.1080/08958378.2024.2351098

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Yeast Expressing a Phage Endolysin Reduces Endogenous in 21-Day-Old Broiler Chicken Intestinal Fluids

Authors: Michael R Barnas, Wendy D Attuquayefio, David M Donovan, Christopher D Skory, Rosemarie W Hammond, Gregory R Siragusa, Jennifer R Timmons

Journal: Avian Dis

PubMed ID: 38885054

Doi: 10.1637/aviandiseases-D-23-00088

Products & Services: Molecular Biology Reagents

Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity

Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee

Journal: J Allergy Clin Immunol

PubMed ID: 38878020

Doi: 10.1016/j.jaci.2024.03.029

Products & Services: Proteins, Expression, Isolation and Analysis

Dietary intake of a MFGM/EV-rich concentrate promotes accretion of very long odd-chain sphingolipids and increases lipid metabolic turnover at the whole-body level

Authors: Richard R Sprenger, Mesut Bilgin, Marie S Ostenfeld, Ann Bjørnshave, Jan T Rasmussen, Christer S Ejsing

Journal: Food Res Int

PubMed ID: 38945615

Doi: 10.1016/j.foodres.2024.114601

Products & Services: Proteins, Expression, Isolation and Analysis

Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles

Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei

Journal: Macromol Rapid Commun

PubMed ID: 38923127

Doi: 10.1002/marc.202400173

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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning

Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos

Journal: Tumour Virus Res

PubMed ID: 38909779

Doi: 10.1016/j.tvr.2024.200287

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses

Authors: Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan

Journal: J Virol

PubMed ID: 38829138

Doi: 10.1128/jvi.00769-24

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Mapping the structural landscape of the yeast Ty3 retrotransposon RNA genome

Authors: Angelika Andrzejewska-Romanowska, Julita Gumna, Ewa Tykwińska, Katarzyna Pachulska-Wieczorek

Journal: Nucleic Acids Res

PubMed ID: 38864374

Doi: 10.1093/nar/gkae494

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside

Authors: Yating Liu, Xiaoyang Han, Mengya Zhao, Lan Liu, Zixin Deng, Qiu Zhao, Yi Yu

Journal: PLANT JOURNAL

PubMed ID: 38872484

Doi: 10.1111/tpj.16807

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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis

Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan

Journal: Biochem Biophys Res Commun .

PubMed ID: 38626621

Doi: 10.1016/j.bbrc.2024.149934

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Next-generation nanovaccine induces durable immunity and protects against SARS-CoV-2

Authors: Kathleen A Ross, Sean Kelly, Kruttika S Phadke, Nathan Peroutka-Bigus, Olufemi Fasina, Alaric Siddoway, Surya K Mallapragada, Michael J Wannemuehler, Bryan H Bellaire, Balaji Narasimhan

Journal: Acta Biomater

PubMed ID: 38844193

Doi: 10.1016/j.actbio.2024.05.048

Products & Services: Molecular Biology Reagents

Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma

Journal: Clinics (Sao Paulo)

PubMed ID: 38901133

Doi: 10.1016/j.clinsp.2024.100410

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Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics

Authors: Eun Jung Sohn, Kun-Taek Park

Journal: Neuroreport

PubMed ID: 38935077

Doi: 10.1097/WNR.0000000000002066

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High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling

Authors: Jayati Gera, Dheeraj Kumar, Gunjan Chauhan, Adarsh Choudhary, Lavi Rani, Lolitika Mandal, Sudip Mandal

Journal: J Cell Biol

PubMed ID: 38916917

Doi: 10.1083/jcb.202306087

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Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells

Authors: Tania G Heredia-Torres, Veronica Alvarado-Martínez, Ana R Rincon-Sanchez, Sonia A Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Ana M Rivas-Estilla

Journal: Ann Hepatol

PubMed ID: 38852781

Doi: 10.1016/j.aohep.2024.101517

Products & Services: Molecular Biology Reagents

Sequence and structure analyses of lytic polysaccharide monooxygenases mined from metagenomic DNA of humus samples around white-rot fungi in Cuc Phuong tropical forest, Vietnam

Authors: Nam-Hai Truong, Thi-Thu-Hong Le, Hong-Duong Nguyen, Hong-Thanh Nguyen, Trong-Khoa Dao, Thi-Minh-Nguyet Tran, Huyen-Linh Tran, Dinh-Trong Nguyen, Thi-Quy Nguyen, Thi-Hong-Thao Phan, Thi-Huyen Do, Ngoc-Han Phan, Thi-Cam-Nhung Ngo, Van-Van Vu

Journal: PeerJ

PubMed ID: 38938609

Doi: 10.7717/peerj.17553

Products & Services: Molecular Biology Reagents

nCas9 Engineering for Improved Target Interaction Presents an Effective Strategy to Enhance Base Editing

Authors: Guiquan Zhang, Ziguo Song, Shisheng Huang, Yafeng Wang, Jiayuan Sun, Lu Qiao, Guanglei Li, Yuanyuan Feng, Wei Han, Jin Tang, Yulin Chen, Xingxu Huang, Furui Liu, Xiaolong Wang, Jianghuai Liu

Journal: Adv Sci (Weinh)

PubMed ID: 38881503

Doi: 10.1002/advs.202405426

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Improvement of TaC9-ABE mediated correction of human SMN2 gene

Authors: Xiaohua Peng, Yue Chi, Jinling Wang, Shuangpeng Li, Yang Liu, Chengcheng Tang, Xiaoqing Zhou, Xuan Lu, Yue Gao, Liangxue Lai, Min Chen, Qingjian Zou

Journal: Biotechnol Bioeng

PubMed ID: 38923503

Doi: 10.1002/bit.28780

Products & Services: GenCrispr Cas9 Genome Editing

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor

Authors: Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H Eric Xu, Jia Duan

Journal: Cell Rep

PubMed ID: 38935498

Doi: 10.1016/j.celrep.2024.114389

Products & Services: Recombinant Proteins

Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly

Journal: Structure

PubMed ID: 38870939

Doi: 10.1016/j.str.2024.05.011

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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

Journal: PLoS Pathog

PubMed ID: 38829892

Doi: 10.1371/journal.ppat.1012289

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The role of shear forces in primary and secondary nucleation of amyloid fibrils

Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38875148

Doi: 10.1073/pnas.2322572121

Products & Services: Molecular Biology Reagents

Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu

Journal: Pharmaceutics

PubMed ID: 38931944

Doi: 10.3390/pharmaceutics16060824

Products & Services: Molecular Biology Reagents

The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis

Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem

Journal: G3 (Bethesda)

PubMed ID: 38839055

Doi: 10.1093/g3journal/jkae122

Products & Services: Molecular Biology Reagents

The annotation of has been concealed by its protein-coding pseudogene

Authors: Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten

Journal: Sci Adv

PubMed ID: 38924406

Doi: 10.1126/sciadv.adk1296

Products & Services: Proteins, Expression, Isolation and Analysis

Arabidopsis pollen prolyl-hydroxylases P4H4/6 are relevant for correct hydroxylation and secretion of LRX11 in pollen tubes

Authors: Ana R Sede, Diego L Wengier, Cecilia Borassi, Martiniano Ricardi, Sofía C Somoza, Rafael Aguiló, José M Estevez, Jorge P Muschietti

Journal: J Exp Bot

PubMed ID: 38877792

Doi: 10.1093/jxb/erae269

Products & Services: Proteins, Expression, Isolation and Analysis

Ancient nitrogenases are ATP dependent

Authors: Derek F Harris, Holly R Rucker, Amanda K Garcia, Zhi-Yong Yang, Scott D Chang, Hannah Feinsilber, Betül Kaçar, Lance C Seefeldt

Journal: MBio

PubMed ID: 38869277

Doi: 10.1128/mbio.01271-24

Products & Services: Proteins, Expression, Isolation and Analysis

MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling

Authors: Yan Cai, Yi Zhang, Sihan Wang, E Changyong

Journal: Mol Immunol

PubMed ID: 38901181

Doi: 10.1016/j.molimm.2024.06.002

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PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2

Authors: Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito

Journal: Sci Rep

PubMed ID: 38844490

Doi: 10.1038/s41598-024-63239-w

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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns

Authors: Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco

Journal: RNA

PubMed ID: 38575347

Doi: 10.1261/rna.079933.123

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of Monovalent Direct Degraders of BRD4 That Act Via the Recruitment of DCAF11

Authors: Gregory S Parker, Julia I Toth, Sarah Fish, Gabrielle A Blanco, Taylor Kampert, Xiaoming Li, Linette Yang, Craig R Stumpf, Kenneth Steadman, Aleksandar Jamborcic, Stephen Chien, Elizabeth Daniele, Alejandro Dearie, Geoffray Leriche, Simon Bailey, Peggy A Thompson

Journal: Mol Cancer Ther

PubMed ID: 38907538

Doi: 10.1158/1535-7163.MCT-24-0219

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular Mechanism of WWOX Inhibiting the Development of Esophageal Cancer by Inhibiting Hippo Signaling Pathway

Authors: Zihan Chen, Jingyu Sun, Lili Zhang, Yanglin Sun, Qingqing Ni, Hongkun Zhu, Miao Hui, Longzhen Zhang, Qiang Wang

Journal: Biochem Genet

PubMed ID: 38902482

Doi: 10.1007/s10528-024-10856-9

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Integration of Image Pattern Recognition and Photon Sensor for Analyzing Cytokine Gene Expression Using πCode MicroDisc

Authors: On-Anong Juntit, Kanokporn Sornsuwan, Umpa Yasamut, Chatchai Tayapiwatana

Journal: Biosensors (Basel)

PubMed ID: 38920610

Doi: 10.3390/bios14060306

Products & Services: Recombinant Proteins

T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector

Authors: Ingrid Fert, Laëtitia Douguet, Benjamin Vesin, Fanny Moncoq, Amandine Noirat, Pierre Authié, Sylvain Ciret, Fabien Le Chevalier, Catherine Blanc, Yakov Vitrenko, Pierre Charneau, Laleh Majlessi, François Anna

Journal: npj Vaccines

PubMed ID: 38858404

Doi: 10.1038/s41541-024-00894-0

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of transmission-blocking potential of PvPSOP25 using transgenic murine malaria parasite and clinical isolates

Authors: Biying Zhang, Hao Feng, Yan Zhao, Di Zhang, Xinxin Yu, Yusi Li, Ying Zeng, Sataporn Thongpoon, Wanlapa Roobsoong, Yudi Wu, Fei Liu, Jetsumon Sattabongkot, Hui Min, Liwang Cui, Yaming Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 38865344

Doi: 10.1371/journal.pntd.0012231

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Comparison of the performance of SAG2, GRA6, and GRA7 for serological diagnosis of infection in cats

Authors: Serges Sabukunze, Haorong Gu, Lin Zhao, Honglin Jia, Huanping Guo

Journal: Front Vet Sci

PubMed ID: 38898997

Doi: 10.3389/fvets.2024.1423581

Products & Services: Proteins, Expression, Isolation and Analysis

Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesion Ability

Authors: Yuanxing Shi, Yun Xu, Longyu Zhang, Yunjun Yan, Jinyong Yan

Journal: ACS Appl Bio Mater

PubMed ID: 38926913

Doi: 10.1021/acsabm.4c00455

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Liver-specific DICER1 syndrome model mice develop cystic liver tumors with defective primary cilia

Authors: Keiki Oikawa, Shin-Ichiro Ohno, Kana Ono, Kaito Hirao, Ayano Murakami, Yuichirou Harada, Katsuyoshi Kumagai, Katsuko Sudo, Masakatsu Takanashi, Akio Ishikawa, Shouichirou Mineo, Koji Fujita, Tomohiro Umezu, Noriko Watanabe, Yoshiki Murakami, Shinichiro Ogawa, Kris Ann Schultz, Masahiko Kuroda

Journal: J Pathol

PubMed ID: 38922876

Doi: 10.1002/path.6320

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Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients

Authors: Truong Nguyen Duy, Hoang Le Huy, Quyen Đao Thanh, Hoai Ngo Thi, Hanh Ngo Thi Minh, Manh Nguyen Dang, Song Le Huu, Trung Ngo Tat

Journal: Anaerobe

PubMed ID: 38942229

Doi: 10.1016/j.anaerobe.2024.102880

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Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences

Authors: Michal Chappleboim, Segev Naveh-Tassa, Miri Carmi, Yaakov Levy, Naama Barkai

Journal: Nucleic Acids Res

PubMed ID: 38597680

Doi: 10.1093/nar/gkae249

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A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy

Authors: Zhiyong Shi , Miaomiao Liu , Xiaowen Zhang , Jingyang Wang , Junwei Zhang , Zeyan Peng , Li Meng , Ruijing Wang ,Yang Xu , Jie Yan , Jianlin Cui , Shan Ren , Yang Gao , Yanming Wang , Zhi Qi

Journal: Theranostics

PubMed ID: 38948069

Doi: 10.7150/thno.92119

Products & Services: Nucleic Acid Purification & Analysis

Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot Nematode

Authors: Chenmi Mo, Lei Zhang

Journal: Int J Mol Sci

PubMed ID: 38928010

Doi: 10.3390/ijms25126300

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Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission

Authors: Ellen A Kearney, Punam Amratia, Su Yun Kang, Paul A Agius, Kefyalew Addis Alene, Katherine O'Flaherty, Win Han Oo, Julia C Cutts, Win Htike, Daniela Da Silva Goncalves, Zahra Razook, Alyssa E Barry, Damien Drew, Aung Thi, Kyaw Zayar Aung, Htin Kyaw Thu, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, James G Beeson, Julie A Simpson, Peter W Gething, Ewan Cameron, Freya J I Fowkes

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38833464

Doi: 10.1073/pnas.2320898121

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Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles

Authors: Leticia Guzman Ruiz, Alexander M Zollner, Irene Hoxie, Elsa Arcalis, Florian Krammer, Miriam Klausberger, Alois Jungbauer, Reingard Grabherr

Journal: Front Immunol

PubMed ID: 38915410

Doi: 10.3389/fimmu.2024.1425842

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Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

Authors: Ignacio Fernández, Nell Saunders, Stéphane Duquerroy, William H Bolland, Atousa Arbabian, Eduard Baquero, Catherine Blanc, Pierre Lafaye, Ahmed Haouz, Julian Buchrieser, Olivier Schwartz, Félix A Rey

Journal: Cell

PubMed ID: 38964326

Doi: 10.1016/j.cell.2024.06.007

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Trichostatin A Promotes Cytotoxicity of Cisplatin, as Evidenced by Enhanced Apoptosis/Cell Death Markers

Authors: Yang Zhou, Qun Luo, Fangang Zeng, Xingkai Liu, Juanjuan Han, Liangzhen Gu, Xiao Tian, Yanyan Zhang, Yao Zhao, Fuyi Wang

Journal: Molecules

PubMed ID: 38893499

Doi: 10.3390/molecules29112623

Products & Services: Proteins, Expression, Isolation and Analysis

The porcine circovirus 3 humoral response: characterization of maternally derived antibodies and dynamic following experimental infection

Authors: Molly Kroeger, Gun Temeeyasen, Steven Dilberger-Lawson, Eric Nelson, Ronaldo Magtoto, Luis Gimenez-Lirola, Pablo Piñeyro

Journal: Microbiol Spectr

PubMed ID: 38916319

Doi: 10.1128/spectrum.00870-24

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High-yield porphyrin production through metabolic engineering and biocatalysis

Authors: Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Liming Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang

Journal: Nat Biotechnol

PubMed ID: 38839873

Doi: 10.1038/s41587-024-02267-3

Products & Services: Proteins, Expression, Isolation and Analysis

Drosophila immune cells transport oxygen through PPO2 protein phase transition

Authors: Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim

Journal: Nature

PubMed ID: 38926577

Doi: 10.1038/s41586-024-07583-x

Products & Services: Proteins, Expression, Isolation and Analysis

Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM

Authors: Rajeswari Basu, Richard Dambra, Di Jiang, Sophia A Schätzlein, Shu Njiyang, Joseph Ashour, Abhilash I Chiramel, Adam Vigil, Vladimir V Papov

Journal: Microbiol Spectr

PubMed ID: 38916347

Doi: 10.1128/spectrum.03651-23

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Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis

Authors: Sergi Torres-Puig, Silvia Crespo-Pomar, Hatice Akarsu, Thatcha Yimthin, Valentina Cippà, Thomas Démoulins, Horst Posthaus, Nicolas Ruggli, Peter Kuhnert, Fabien Labroussaa, Jörg Jores

Journal: Commun Biol

PubMed ID: 38942984

Doi: 10.1038/s42003-024-06497-8

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Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage

Authors: Sarah Stuart, Daniel Tarade, Michael Ohh

Journal: Sci Rep

PubMed ID: 38926538

Doi: 10.1038/s41598-024-65537-9

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Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Authors: Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Dustin S Siegel, Jason K Perry, Joy Y Feng, John P Bilello, Matthias Götte

Journal: J Biol Chem

PubMed ID: 38945449

Doi: 10.1016/j.jbc.2024.107514

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Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen

Authors: Ann Fernando, Amanda Sparkes, Esther I Matus, Ayushi Patel, F Stuart Foster, David Goertz, Peter Lee, Jean Gariépy

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38898951

Doi: 10.1021/acsptsci.4c00140

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Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

Authors: Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun, Yuliang Zhang, Sean F Gilmore, Megan Shelby, Feliza Bourguet, Mariam Mohagheghi, Aleksandr Noy, Amy Rasley, Luis M de la Maza, Matthew A Coleman

Journal: biorxiv

PubMed ID: 38895407

Doi: 10.1101/2024.06.04.597210

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Deciphering Structural Traits for Thermal and Kinetic Stability Across Protein Family Evolution through Ancestral Sequence Reconstruction

Authors: Pablo A Cea, Myriam Pérez, Sixto M Herrera, Sebastián M Muñoz, Nicolás Fuentes-Ugarte, José Coche-Miranda, Pablo Maturana, Victoria Guixé, Victor Castro-Fernandez

Journal: Mol Biol Evol

PubMed ID: 38913681

Doi: 10.1093/molbev/msae127

Products & Services: DNA Sequencing

Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Expression Correlates With a Metastatic-like Phenotype in Epidermoid Carcinoma, Pediatric Medulloblastoma, and Mesothelioma

Authors: Jorge Marquez, Jianping Dong, Jun Hayashi, Ginette Serrero

Journal: J Cell Biochem

PubMed ID: 38924562

Doi: 10.1002/jcb.30616

Products & Services: Proteins, Expression, Isolation and Analysis

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Authors: Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang

Journal: Nat Prod Bioprospect

PubMed ID: 38833115

Doi: 10.1007/s13659-024-00458-8

Products & Services: Proteins, Expression, Isolation and Analysis

A Plasmodium apicoplast-targeted unique exonuclease/FEN exhibits interspecies functional differences attributable to an insertion that alters DNA-binding

Authors: Tribeni Chatterjee, Anupama Tiwari, Ritika Gupta, Himadri Shukla, Aastha Varshney, Satish Mishra, Saman Habib

Journal: Nucleic Acids Res

PubMed ID: 38888125

Doi: 10.1093/nar/gkae512

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A chimeric membrane enzyme and an engineered whole-cell biocatalyst for efficient 1-alkene production

Authors: Tabish Iqbal, Subhashini Murugan, Debasis Das

Journal: Sci Adv

PubMed ID: 38924395

Doi: 10.1126/sciadv.adl2492

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of dilution rate and mixed carbon feed for continuous production of recombinant plant sucrose:sucrose 1-fructosyltransferase in Komagataella phaffii

Authors: Avijeet S Jaswal, Ravikrishnan Elangovan, Saroj Mishra

Journal: Bioprocess Biosyst Eng

PubMed ID: 38904715

Doi: 10.1007/s00449-024-03045-w

Products & Services: PCR Cloning and Subcloning

CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels

Authors: Yin Liu, Xinyi Liu, Dongyi Wei, Lu Dang, Xiaoran Xu, Shisheng Huang, Liwen Li, Sanyun Wu, Jinxian Wu, Xiaoyan Liu, Wenjun Sun, Wanyu Tao, Yongchang Wei, Xingxu Huang, Kui Li, Xinjie Wang, Fuling Zhou

Journal: Nat Commun

PubMed ID: 38866774

Doi: 10.1038/s41467-024-49414-7

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SepM mutation in Streptococcus mutans clinical isolates and related function analysis

Authors: Shanshan Liu, Yidan Shao, Zhenzhen Zhang, Wen Xu, Yudong Liu, Kai Zhang, Li Xu, Qingwei Zheng, Yu Sun

Journal: BMC Oral Health

PubMed ID: 38918777

Doi: 10.1186/s12903-024-04436-x

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Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria

Authors: Hunter L Abrahamsen, Tristan C Sanford, Casie E Collamore, Bronte A Johnstone, Michael J Coyne, Leonor García-Bayona, Michelle P Christie, Jordan C Evans, Allison J Farrand, Katia Flores, Craig J Morton, Michael W Parker, Laurie E Comstock, Rodney K Tweten

Journal: Nat Commun

PubMed ID: 38866748

Doi: 10.1038/s41467-024-49103-5

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GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway

Authors: Jiahua Yang, Xuechuan Li, Shili Chen, Guoqiang Li, Peng Pu, Yang Yang, Wenguang Wu, Yajun Geng, Yingbin Liu

Journal: Cancer Lett

PubMed ID: 38942137

Doi: 10.1016/j.canlet.2024.217067

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OsNLP3 enhances grain weight and reduces grain chalkiness in rice

Authors: Liang-Qi Sun, Yu Bai, Jie Wu, Shi-Jun Fan, Si-Yan Chen, Zheng-Yi Zhang, Jin-Qiu Xia, Shi-Mei Wang, Yu-Ping Wang, Peng Qin, Shi-Gui Li, Ping Xu, Zhong Zhao, Cheng-Bin Xiang, Zi-Sheng Zhang

Journal: Plant Commun

PubMed ID: 38853433

Doi: 10.1016/j.xplc.2024.100999

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M tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia

Authors: Yannik A Haller, Jiapei Jiang, Zijian Wan, Alexia Childress, Shaopeng Wang, Shelley E Haydel

Journal: Tuberculosis (Edinb)

PubMed ID: 38885567

Doi: 10.1016/j.tube.2024.102531

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Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2

Authors: Lesley Umeda, Amada Torres, Braden P Kunihiro, Noelle C Rubas, Riley K Wells, Krit Phankitnirundorn, Rafael Peres, Ruben Juarez, Alika K Maunakea

Journal: Vaccines (Basel)

PubMed ID: 38932366

Doi: 10.3390/vaccines12060637

Products & Services: Gene Synthesis

An optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS

Authors: Mariana Lopes, Peder J Lund, Benjamin A Garcia

Journal: biorxiv

PubMed ID: 38915586

Doi: 10.1101/2024.06.11.596744

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Identification of a human type XVII collagen fragment with high capacity for maintaining skin health

Authors: Xinglong Wang, Shuyao Yu, Ruoxi Sun, Kangjie Xu, Kun Wang, Ruiyan Wang, Junli Zhang, Wenwen Tao, Shangyang Yu, Kai Linghu, Xinyi Zhao, Jingwen Zhou

Journal: Synth Syst Biotechnol

PubMed ID: 38911060

Doi: 10.1016/j.synbio.2024.06.001

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The Gene Network That Regulates Head Organizer Activity in Is Differentially Regulated in Epidermis and Gastrodermis

Authors: Laura Iglesias Ollé, Chrystelle Perruchoud, Paul Gerald Layague Sanchez, Matthias Christian Vogg, Brigitte Galliot

Journal: Biomedicines

PubMed ID: 38927481

Doi: 10.3390/biomedicines12061274

Products & Services: DNA Sequencing

A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle

Authors: Xiaoyou Hu, Xu Bai, Fangling Tian, Yifan Xing, Yi Shi, Yimin Tong, Jin Zhong

Journal: Emerg Microbes Infect

PubMed ID: 38747061

Doi: 10.1080/22221751.2024.2356149

Metabolic Engineering of for Production of Canthaxanthin, Zeaxanthin, and Astaxanthin

Authors: Peerada Promdonkoy, Akaraphol Watcharawipas, Suriyaporn Bubphasawan, Kitisak Sansatchanon, Nattida Suwanakitti, Kanokarn Kocharin, Weerawat Runguphan

Journal: J Fungi (Basel)

PubMed ID: 38921419

Doi: 10.3390/jof10060433

Products & Services: Codon Optimization

Distance tuneable integral membrane protein containing floating bilayers directed self-assembly

Authors: Stephen C L Hall, David J Hardy, Éilís C Bragginton, Hannah Johnston, Tudor Onose, Rachel Holyfield, Pooja Sridhar, Timothy J Knowles, Luke A Clifton

Journal: Nanoscale

PubMed ID: 38940744

Doi: 10.1039/d3nr04622b

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant Art v401 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model

Authors: Tao Wang, Jiaoni Chi, Zhimin Li, Yue Zhang, Yaojun Wang, Ming Ding, Bin Zhou, JiaChen Gui, Qiang Li

Journal: PLoS ONE

PubMed ID: 38941291

Doi: 10.1371/journal.pone.0280418

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Plasmodium vivax serological exposure markers: PvMSP1-42-induced humoral and memory B-cell response generates long-lived antibodies

Authors: Feng Lu, Jiahui Xu, Yaobao Liu, Zhenyu Ren, Junhu Chen, Weijuan Gong, Yi Yin, Yinyue Li, Li Qian, Xinlong He, Xiu Han, Zhijie Lin, Jingyuan Lu, Wenwen Zhang, Jiali Liu, Didier Menard, Eun-Taek Han, Jun Cao

Journal: PLoS Pathog

PubMed ID: 38941356

Doi: 10.1371/journal.ppat.1012334

Products & Services: Proteins, Expression, Isolation and Analysis

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer

Authors: Jianbo Shen, Niliang Qian, Guili Xu, Xiaoqian Dou, Ying An, Cuima Yang, Yujie Liu, Yunhui Liu, Xiujie Pan, Jingjing Wang, Guijun Bai, Hao Chen, Xiaolin Zhu, Xin Gao, Guoxiong Zhou, Qinzhi Xu

Journal: Int Immunopharmacol

PubMed ID: 38878486

Doi: 10.1016/j.intimp.2024.112424

Products & Services: Proteins, Expression, Isolation and Analysis

Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity

Authors: Hua-Lin You, Bo Zhou, Meng-Jia Guo, Xin-Man Zhao, Xiao-Long Li, Xiang-Chun Shen, Nen-Ling Zhang

Journal: Phytochemistry

PubMed ID: 38945281

Doi: 10.1016/j.phytochem.2024.114197

Products & Services: PCR Cloning and Subcloning

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Authors: Gi Young Lee, Jeongmin Song

Journal: Nat Commun

PubMed ID: 38898034

Doi: 10.1038/s41467-024-49590-6

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A 14-amino acid cationic peptide Bolespleenin from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential

Authors: Yuqi Bai, Weibin Zhang, Wenbin Zheng, Xin-Zhan Meng, Yingyi Duan, Chang Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Biochem Pharmacol

PubMed ID: 38852647

Doi: 10.1016/j.bcp.2024.116344

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The role of MASP1 in the complement system and expression characteristics in response to GCRV infection in grass carp

Authors: Yuling Wei, Zhao Lv, Tiaoyi Xiao, Zongjun Du

Journal: Fish Shellfish Immunol

PubMed ID: 38901682

Doi: 10.1016/j.fsi.2024.109712

Products & Services: Proteins, Expression, Isolation and Analysis

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Authors: Vadim A Klenchin, Natasha M Clark, Nida K Keles, Saverio Capuano, Rosemarie Mason, Guangping Gao, Aimee Broman, Emek Kose, Taina T Immonen, Christine M Fennessey, Brandon F Keele, Jeffrey D Lifson, Mario Roederer, Matthew R Gardner, David T Evans

Journal: biorxiv

PubMed ID: 38895320

Doi: 10.1101/2024.05.30.593694

Products & Services: Codon Optimization

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Authors: Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu, Jielin Tang, Mengrong Yan, Qiong Wu, Ruyi Chen, Anqi Zhou, Lijie Liu, Junjun Liu, Changbin Qu, Qingxin Wu, Muqing Fu, Jiayi Zhong, Jianwei Dong, Sijie Chen, Fan Wang, Yuan Zhou, Jie Zheng, Wei Peng, Jinsai Shang, Xinwen Chen

Journal: Signal Transduct Target Ther

PubMed ID: 38853183

Doi: 10.1038/s41392-024-01858-5

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Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Authors: Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridge

Journal: J Neuroinflammation

PubMed ID: 38840206

Doi: 10.1186/s12974-024-03130-7

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Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

Authors: Shenlin Hsiao, Shuanghong Chen, Yanhong Jiang, Qiudao Wang, Yang Yang, Yongrong Lai, Tao Zhong, Jiaoyang Liao, Yuxuan Wu

Journal: Adv Sci (Weinh)

PubMed ID: 38874509

Doi: 10.1002/advs.202309004

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Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Authors: Shan-Shan Zhang, Lance Larrabee, Andrew H Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C Hartman, Abby Whitnall, Joseph Mason, Nicholas P Barton, Audrey Y Chu, Jonathan M Davitte, Adam J Csakai, Caitlin Vestal Tibbetts, Audrey E Tolbert, Heather O'Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P Mayer, Patrick Koenig, Davide Foletti, Steven J Pitts, Christine G Schnackenberg

Journal: Sci Rep

PubMed ID: 38851835

Doi: 10.1038/s41598-024-62804-7

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A phage nucleus-associated protein from the jumbophage Churi inhibits bacterial growth through protein translation interference

Authors: Wichanan Wannasrichan, Sucheewin Krobthong, Chase J Morgan, Emily G Armbruster, Milan Gerovac, Yodying Yingchutrakul, Patompon Wongtrakoongate, Jörg Vogel, Chanat Aonbangkhen, Poochit Nonejuie, Joe Pogliano, Vorrapon Chaikeeratisak

Journal: biorxiv

PubMed ID: 38915640

Doi: 10.1101/2024.06.15.599175

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The pigeon circovirus evolution, epidemiology and interaction with the host immune system under One Loft Race rearing conditions

Authors: Tomasz Stenzel, Daria Dziewulska, Ewa Łukaszuk, Joy M Custer, Matthew D De Koch, Simona Kraberger, Arvind Varsani

Journal: Sci Rep

PubMed ID: 38877168

Doi: 10.1038/s41598-024-64587-3

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Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Authors: Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini

Journal: Acta Neuropathologica

PubMed ID: 38886865

Doi: 10.1186/s40478-024-01813-z

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A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in Klebsiella pneumoniae

Authors: Chunyu Jiang, Chengzhi Yu, Shuyi Sun, Jiajia Lin, Mufeng Cai, Zhenquan Wei, Lingling Feng, Jianhui Li, Yan Zhang, Ke Dong ... Show moreAuthor Notes

Journal: Nucleic Acids Res

PubMed ID: 38888121

Doi: 10.1093/nar/gkae516

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Structural basis for an early stage of the photosystem II repair cycle in Chlamydomonas reinhardtii

Authors: Anjie Li, Tingting You, Xiaojie Pang, Yidi Wang, Lijin Tian, Xiaobo Li & Zhenfeng Liu

Journal: Nature Communications

PubMed ID: 38890314

Doi: 10.1038/s41467-024-49532-2

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Improved protein splicing through viral passaging

Authors: Adam J Hume , Dylan J Deeney , John S Smetana , Jacquelyn Turcinovic , John H Connor , Marlene Belfort , Elke Mühlberger , Christopher W Lennon

Journal: MBio

PubMed ID: 38780266

Doi: 10.1128/mbio.00984-24

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Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency

Authors: Yanli Song, Jiaolei Wang, Zhihui Yang, Changgui Li

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2024.1406138

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Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function

Authors: Zichao Zhang , Jing Chen , Rongze Ma , Chongshen Xu , Yunzhe Lu , Jiecan Zhou , Kun Xia , Pengfei Lu

Journal: Adv Sci (Weinh)

PubMed ID: 38884279

Doi: 10.1002/advs.202308822

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A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses

Authors: Yingdan Wang # 1 2, Aihua Hao # 1, Ping Ji # 1, Yunping Ma # 1 3, Zhaoyong Zhang # 4, Jiali Chen 1, Qiyu Mao 1, Xinyi Xiong 4, Palizhati Rehati 1, Yajie Wang 1, Yanqun Wang 4, Yumei Wen 1, Lu Lu 1, Zhenguo Chen 1, Jincun Zhao 5 6, Fan Wu 7, Jinghe Huang 8 9, Lei Sun 10

Journal: Nat Commun

PubMed ID: 38879565

Doi: 10.1038/s41467-024-49096-1

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The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

Authors: Pengfei Yan , Xi Lin , Lijie Wu , Lu Xu , Fei Li , Junlin Liu , Fei Xu

Journal: Nat Commun

PubMed ID: 38898050

Doi: 10.1038/s41467-024-49625-y

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Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Authors: Zhongyuan Zhang , You Zheng , Lu Xu , Yang Yue , Kexin Xu , Fei Li 1, Fei Xu

Journal: Cell Discov

PubMed ID: 38918398

Doi: 10.1038/s41421-024-00698-5

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