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Synthetic genomes unveil the effects of synonymous recoding

Authors: Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Dawn Chen, Jenny Ahn, Owen Spencer, Venkat Ayalavarapu, Angela Tarver, Miranda Harmon-Smith, Matthew Hamilton, Ian Blaby, Yasuo Yoshikuni, Behnoush Hajian, Adeline Jin, Balint Kintses, Monika Szamel, Viktoria Seregi, Yue Shen, Zilong Li, George M Church

Journal: biorxiv

PubMed ID: 38915524

Doi: 10.1101/2024.06.16.599206

Products & Services: Gene Synthesis

The Human Genetic Differences in the Outcomes of mRNA Vaccination against COVID-19: A Prospective Cohort Study

Authors: Ha-Eun Ryu, Jihyun Yoon, Ja-Eun Choi, Seok-Jae Heo, Kyung-Won Hong, Dong-Hyuk Jung

Journal: Vaccines (Basel)

PubMed ID: 38932355

Doi: 10.3390/vaccines12060626

Products & Services: Molecular Biology Reagents

PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation

Authors: Antonio Ruiz-Albor, Belén Chaves-Arquero, Inés Martín-Barros, Alejandra Guerra-Castellano, Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Nekane Merino, Mariola Ferreras-Gutiérrez, Edurne Berra, Irene Díaz-Moreno, Francisco J Blanco

Journal: Int J Biol Macromol

PubMed ID: 38880460

Doi: 10.1016/j.ijbiomac.2024.133187

Products & Services: Proteins, Expression, Isolation and Analysis

Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline

Authors: Brenna Norton-Baker, Mackenzie C R Denton, Natasha P Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P Gauthier, Gregg T Beckham

Journal: Sci Rep

PubMed ID: 38914665

Doi: 10.1038/s41598-024-64938-0

Products & Services: Proteins, Expression, Isolation and Analysis

Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression

Authors: Jun-Sheng Ni, Si-Yuan Fu, Zong-Yan Wang, Wen-Bin Ding, Jian Huang, Xing-Gang Guo, Fang-Ming Gu

Journal: J Gene Med

PubMed ID: 38860366

Doi: 10.1002/jgm.3693

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14

Authors: Drayson Graves, Nikolas Akkerman, Lauren Fulham, Rafe Helwer, Peter Pelka

Journal: MBio

PubMed ID: 38940561

Doi: 10.1128/mbio.01038-24

Products & Services: Proteins, Expression, Isolation and Analysis

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

Authors: Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan

Journal: biorxiv

PubMed ID: 38895352

Doi: 10.1101/2024.06.04.597282

Products & Services: Proteins, Expression, Isolation and Analysis

In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade

Authors: Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu

Journal: Immunol Lett

PubMed ID: 38925442

Doi: 10.1016/j.imlet.2024.106887

Products & Services: Proteins, Expression, Isolation and Analysis

RcOST1L phosphorylates RcPIF4 for proteasomal degradation to promote flowering in rose

Authors: Jingjing Sun, Hongchi Liu, Weinan Wang, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jun Lu, Jinyi Liu, Changquan Wang

Journal: New Phytol

PubMed ID: 38849320

Doi: 10.1111/nph.19885

Products & Services: Gene Synthesis

Characterization of Two Glycoside Hydrolases of Family GH13 and GH57, Present in a Polysaccharide Utilization Locus (PUL) of sp SGAir0037

Authors: Hilda Hubertha Maria Bax, Edita Jurak

Journal: Molecules

PubMed ID: 38930854

Doi: 10.3390/molecules29122788

Products & Services: Molecular Biology Reagents

Metal binding feature of copper‒induced metallothionein from freshwater crab Sinopotamon henanense reveals its Cu‒thionein character

Authors: Huizhen Yang, Ziyan Zhao, Hongquan Li, Lan Wang

Journal: Protein Expr Purif

PubMed ID: 38830441

Doi: 10.1016/j.pep.2024.106519

Products & Services: Gene Synthesis

Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing

Authors: Yaoqi Sun, Bing Xiong, Xueqian Shuai, Jiale Li, Chunyan Wang, Jing Guo, Zhongping Cheng, Shupeng Liu

Journal: Mol Med

PubMed ID: 38867190

Doi: 10.1186/s10020-024-00849-0

Products & Services: Catalog Peptides

Surface functionalization of virus-like particles via bioorthogonal click reactions for enhanced cell-specific targeting

Authors: Chavee Laomeephol, Supannikar Tawinwung, Koramit Suppipat, Wanatchaporn Arunmanee, Qian Wang, Jittima Amie Luckanagul

Journal: Int J Pharm

PubMed ID: 38866085

Doi: 10.1016/j.ijpharm.2024.124332

Products & Services: Proteins, Expression, Isolation and Analysis

Developing deprotectase biocatalysts for synthesis

Authors: Lisa Kennedy, Mariyah Sajjad, Michael A Herrera, Peter Szieber, Natasza Rybacka, Yinan Zhao, Craig Steven, Zainab Alghamdi, Ivan Zlatkov, Julie Hagen, Chloe Lauder, Natalie Rudolfova, Magdalena Abramiuk, Karolina Bolimowska, Daniel Joynt, Angelica Lucero, Gustavo Perez Ortiz, Annamaria Lilienkampf, Alison N Hulme, Dominic J Campopiano

Journal: Faraday Discuss

PubMed ID: 38856717

Doi: 10.1039/d4fd00016a

Products & Services: Gene Synthesis

Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

Authors: Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang

Journal: Mol Med

PubMed ID: 38867145

Doi: 10.1186/s10020-024-00854-3

Products & Services: Proteins, Expression, Isolation and Analysis

MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Authors: Yen-Nien Liu, Wei-Yu Chen, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Phan Vu Thuy Dung, Zi-Qing Chen, Wei-Jiunn Lee, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen

Journal: Sci Signal

PubMed ID: 38861615

Doi: 10.1126/scisignal.adc9142

Products & Services: Proteins, Expression, Isolation and Analysis

Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis

Authors: Elisa Perez-Moreno, Tomás Toledo, Pascale Campusano, Sebastián Zuñiga, Lorena Azócar, Teo Feuerhake, Gonzalo P Méndez, Mariana Labarca, Francisca Pérez-Molina, Adely de la Peña, Cristian Herrera-Cid, Pamela Ehrenfeld, Alejandro S Godoy, Alfonso González, Andrea Soza

Journal: Biomed Pharmacother

PubMed ID: 38936192

Doi: 10.1016/j.biopha.2024.116923

Products & Services: Proteins, Expression, Isolation and Analysis

Unveiling of the Co-Infection of Peste des Petits Ruminants Virus and Caprine Enterovirus in Goat Herds with Severe Diarrhea in China

Authors: Qun Zhang, Xuebo Zheng, Fan Zhang, Xuyuan Cui, Naitian Yan, Junying Hu, Yidi Guo, Xinping Wang

Journal: Viruses

PubMed ID: 38932277

Doi: 10.3390/v16060986

Products & Services: Proteins, Expression, Isolation and Analysis

Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth

Authors: Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer

Journal: Cell Death Differ

PubMed ID: 38858548

Doi: 10.1038/s41418-024-01319-0

Products & Services: Molecular Biology Reagents

Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody

Authors: Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-Anong Juntit, Umpa Yasamut, Nuchjira Takheaw, Watchara Kasinrerk, Phenphichar Wanachantararak, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Nutjeera Intasai, Chatchai Tayapiwatana

Journal: Int J Mol Sci

PubMed ID: 38928332

Doi: 10.3390/ijms25126626

Products & Services: Codon Optimization

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Authors: Desmond Richmond-Buccola, Samuel J Hobbs, Jasmine M Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S Y Lee, Philip J Kranzusch

Journal: Cell Host Microbe

PubMed ID: 38917809

Doi: 10.1016/j.chom.2024.05.021

Products & Services: Proteins, Expression, Isolation and Analysis

Dissecting the dynamics of SARS-CoV-2 reinfections in blood donors with pauci- or asymptomatic COVID-19 disease course at initial infection

Authors: Alexandra Domnica Hoeggerl, Verena Nunhofer, Lisa Weidner, Wanda Lauth, Georg Zimmermann, Natalie Badstuber, Christoph Grabmer, Orkan Kartal, Christof Jungbauer, Heidrun Neureiter, Nina Held, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger

Journal: Infect Dis (Lond)

PubMed ID: 38869944

Doi: 10.1080/23744235.2024.2367112

Products & Services: Proteins, Expression, Isolation and Analysis

Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset

Authors: Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudio Franceschi, Ivan Doykov, Justyna Śpiewak, Héloїse Vinette, Claudia Trenkwalder, Wendy E Heywood, Kevin Mills, Brit Mollenhauer

Journal: Nat Commun

PubMed ID: 38890280

Doi: 10.1038/s41467-024-48961-3

Products & Services: Peptide Synthesis

SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution

Authors: Yao Yao, Zhiwei Zhou, Xiaoling Wang, Zhirui Liu, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue, Shuquan Rao

Journal: Cell Genom

PubMed ID: 38889719

Doi: 10.1016/j.xgen.2024.100583

Products & Services: Synthetic sgRNA and crRNA Service

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Authors: Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde

Journal: Nat Metab

PubMed ID: 38871982

Doi: 10.1038/s42255-024-01061-4

Products & Services: Molecular Biology Reagents

GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening

Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner

Journal: ACS Omega

PubMed ID: 38947828

Doi: 10.1021/acsomega.4c01583

Products & Services: Gene Synthesis

Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu

Journal: BMC Plant Biol

PubMed ID: 38851686

Doi: 10.1186/s12870-024-05189-z

Products & Services: PCR Cloning and Subcloning

CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p

Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie

Journal: Genesis

PubMed ID: 38764323

Doi: 10.1002/dvg.23599

Products & Services: Mutant Libraries

N-terminal cysteine acetylation and oxidation patterns may define protein stability

Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Journal: Nat Commun

PubMed ID: 38918375

Doi: 10.1038/s41467-024-49489-2

Products & Services: Catalog Peptides

Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium

Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti

Journal: Int J Biol Macromol

PubMed ID: 38944065

Doi: 10.1016/j.ijbiomac.2024.133449

Products & Services: Gene Synthesis

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis

Authors: Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang

Journal: Free Radic Biol Med

PubMed ID: 38945457

Doi: 10.1016/j.freeradbiomed.2024.06.025

Products & Services: Molecular Biology Reagents

Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis

Authors: Jianwei Liu, Dixing Lin, Jiadong Lu

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 38836662

Doi: 10.14715/cmb/2024.70.6.29

Products & Services: Custom Vector Construction

Characterization of a novel carboxylesterase from Streptomyces lividans TK24 and site-directed mutagenesis for its thermostability

Authors: Jinxin Fang, Lihua An, Jiao Yu, Jinxue Ma, Rongjie Zhou, Baojuan Wang

Journal: J Biosci Bioeng

PubMed ID: 38871580

Doi: 10.1016/j.jbiosc.2024.05.001

Products & Services: Proteins, Expression, Isolation and Analysis

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG antibodies

Authors: Wen-Ting K Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J Carter

Journal: MAbs

PubMed ID: 38845069

Doi: 10.1080/19420862.2024.2362789

Products & Services: Gene Synthesis

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

Products & Services: DNA Sequencing

Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

Products & Services: Molecular Biology Reagents

Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Proteins, Expression, Isolation and Analysis

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Proteins, Expression, Isolation and Analysis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

Products & Services: Gene Synthesis

Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

Products & Services: Catalog Antibody

Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

Products & Services: Gene Synthesis

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Proteins, Expression, Isolation and Analysis

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

Products & Services: DNA Sequencing

Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Proteins, Expression, Isolation and Analysis

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

Products & Services: Gene Synthesis

Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

Authors: Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens

Journal: Nat Struct Mol Biol

PubMed ID: 38918639

Doi: 10.1038/s41594-024-01338-y

Products & Services: Gene Synthesis

Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming

Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding

Journal: Adv Sci (Weinh)

PubMed ID: 38923275

Doi: 10.1002/advs.202309314

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens

Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun

Journal: Marine Life Science & Technology

Doi: //doi.org/10.1007/s42995-024-00237-x

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis

Authors: Ross M Walker, Minquan Zhang, Robert L Burnap

Journal: Biochim Biophys Acta Bioenerg

PubMed ID: 38906312

Doi: 10.1016/j.bbabio.2024.149149

Products & Services: Mutant Libraries

Recovery kinetics of dual AAV-mediated human otoferlin expression

Authors: Jonathan B Sellon, Kathy S So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C Drummond, Peter G Slade, Ning Pan, Tyler M Gibson, Tian Yang, Joseph C Burns, Adam T Palermo, Lars Becker

Journal: Front Mol Neurosci

PubMed ID: 38952419

Doi: 10.3389/fnmol.2024.1376128

Products & Services: Gene Synthesis

Discovery of procyanidin condensed tannins of (-)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2

Authors: Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Journal: Int J Biol Macromol

PubMed ID: 38866269

Doi: 10.1016/j.ijbiomac.2024.133059

Products & Services: Catalog Antibody

Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

Authors: Satyajit Mahapatra, Tomoyuki Takahashi

Journal: Elife

PubMed ID: 38829367

Doi: 10.7554/eLife.90497

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Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

Authors: Ju-Fang Chang, Nils Wellhausen, Nils Wolfgang Engel, Jack H Landmann, Caitlin R Hopkins, January Salas-McKee, Adham S Bear, Mehmet Emrah Selli, Sangya Agarwal, Julie Jadlowsky, Gerald P Linette, Saar Gill, Carl H June, Joseph A Fraietta, Nathan Singh

Journal: Cancer Immunol Res

PubMed ID: 38869428

Doi: 10.1158/2326-6066.CIR-24-0251

Products & Services: Molecular Biology Reagents

Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization

Authors: Benjamin M Janus, Ruixue Wang, Thomas E Cleveland, Matthew C Metcalf, Aaron C Lemmer, Nydia van Dyk, Sarah Jeong, Anagh Astavans, Kenneth Class, Thomas R Fuerst, Gilad Ofek

Journal: J Virol

PubMed ID: 38832790

Doi: 10.1128/jvi.00155-24

Products & Services: Gene Synthesis

One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

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The BEL1-like homeodomain protein OsBLH4 regulates rice plant height, grain number, and heading date by repressing the expression of OsGA2ox1

Authors: Chengjuan Cao, Shuaiqiang Guo, Ping Deng, Shiyi Yang, Jing Xu, Tengfei Hu, Zhijuan Hu, Di Chen, Hongsheng Zhang, Ian Paul Navea, Joong Hyoun Chin, Wenhua Zhang, Wen Jing

Journal: Plant J

PubMed ID: 38824648

Doi: 10.1111/tpj.16857

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Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

Authors: Salinthip Jarusintanakorn, Enrico Mastrobattista, Montarop Yamabhai

Journal: N Biotechnol

PubMed ID: 38945523

Doi: 10.1016/j.nbt.2024.06.006

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

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Enhanced Recombinant Protein Expression in Insect Cells by Natural and Recombinant Components of Lepidoptera Hemolymph

Authors: Javier López-Vidal, Susana Martínez-Pulgarín, Diego Martínez-Alonso, Miguel Cid, José M Escribano

Journal: Viruses

PubMed ID: 38932236

Doi: 10.3390/v16060944

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CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis

Authors: Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi-Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen

Journal: Adv Sci (Weinh)

PubMed ID: 38873823

Doi: 10.1002/advs.202400611

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Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Abraham O Oluwole, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Macie S Sheridan, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: EMBO J

PubMed ID: 38839991

Doi: 10.1038/s44318-024-00132-2

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The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats

Authors: Xin Fang, Richa Tiwary, Vivian P Nguyen, John H Richburg

Journal: Toxicol Sci

PubMed ID: 38565259

Doi: 10.1093/toxsci/kfae043

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Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins

Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza

Journal: Anticancer Res

PubMed ID: 38821612

Doi: 10.21873/anticanres.17062

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A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu

Journal: J Sep Sci

PubMed ID: 38819782

Doi: 10.1002/jssc.202400090

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Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Authors: Jay Kumar, Renu A Kowluru

Journal: Mitochondrion

PubMed ID: 38944370

Doi: 10.1016/j.mito.2024.101925

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APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang

Journal: Cell Mol Biol Lett

PubMed ID: 38867189

Doi: 10.1186/s11658-024-00600-x

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Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu

Journal: Nat Biomed Eng

PubMed ID: 38858586

Doi: 10.1038/s41551-024-01227-1

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An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor

Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang

Journal: J Agric Food Chem

PubMed ID: 38847536

Doi: 10.1021/acs.jafc.4c02968

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Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma

Authors: Kalibixiati Aimulajiang, Wen Chu, Shuyi Liao, Zhaohai Wen, Rongdong He, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: Immun Inflamm Dis

PubMed ID: 38888451

Doi: 10.1002/iid3.1321

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi

Journal: medrxiv

PubMed ID: 38883797

Doi: 10.1101/2024.06.02.24308281

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Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation

Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu

Journal: J Virol

PubMed ID: 38869285

Doi: 10.1128/jvi.00561-24

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Boosting PRRSV-Specific Cellular Immunity: The Immunological Profiling of an Fc-Fused Multi-CTL Epitope Vaccine in Mice

Authors: Xinnuo Lei, Jinzhao Ban, Zhi Wu, Shinuo Cao, Mo Zhou, Li Zhang, Rui Zhu, Huipeng Lu, Shanyuan Zhu

Journal: Vet Sci

PubMed ID: 38922021

Doi: 10.3390/vetsci11060274

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

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DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

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Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

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Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Authors: Shin-Ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko

Journal: Commun Biol

PubMed ID: 38834758

Doi: 10.1038/s42003-024-06297-0

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Capturing totipotency in human cells through spliceosomal repression

Authors: Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, Peng Du

Journal: Cell

PubMed ID: 38843832

Doi: 10.1016/j.cell.2024.05.010

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Molecular Mechanism of GmSNE3 Ubiquitin Ligase-Mediated Inhibition of Soybean Nodulation by Halosulfuron Methyl

Authors: Yuanfu Li, Jingsi Qiu, Jingxia Yang, Yihan Li, Hui Zhang, Feng Zhao, Huihua Tan

Journal: J Agric Food Chem

PubMed ID: 38867659

Doi: 10.1021/acs.jafc.4c02621

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Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography

Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu

Journal: J Chromatogr A

PubMed ID: 38905946

Doi: 10.1016/j.chroma.2024.465107

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Identification of two novel B cell epitopes on E184L protein of African swine fever virus using monoclonal antibodies

Authors: Weldu Tesfagaber, Desong Lan, Wan Wang, Rui Zhao, Li Yin, Mingyang Yang, Yuanmao Zhu, Encheng Sun, Renqiang Liu, Wenjun Lin, Zhigao Bu, Fang Li, Dongming Zhao

Journal: Virus Res

PubMed ID: 38838820

Doi: 10.1016/j.virusres.2024.199412

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Self-assembled protein vesicles as vaccine delivery platform to enhance antigen-specific immune responses

Authors: Yirui Li, Mariela R Rodriguez-Otero, Julie A Champion

Journal: Biomaterials

PubMed ID: 38879893

Doi: 10.1016/j.biomaterials.2024.122666

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Expanding the genetic toolbox for the obligate human pathogen

Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier

Journal: Front Bioeng Biotechnol

PubMed ID: 38911550

Doi: 10.3389/fbioe.2024.1395659

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Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases

Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth

Journal: Pancreatology

PubMed ID: 38876922

Doi: 10.1016/j.pan.2024.06.003

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GhMPK9-GhRAF39_1-GhWRKY40a Regulates the GhERF1b- and GhABF2-Mediated Pathways to Increase Cotton Disease Resistance

Authors: Xinyue Mi, Weixi Li, Chuan Chen, Huijuan Xu, Guilin Wang, Xuanxiang Jin, Dayong Zhang, Wangzhen Guo

Journal: Adv Sci (Weinh)

PubMed ID: 38845189

Doi: 10.1002/advs.202404400

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A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

Authors: Xiaoqing Guan, Abhishek K Verma, Gang Wang, Abhijeet Roy, Stanley Perlman, Lanying Du

Journal: Vaccines (Basel)

PubMed ID: 38932334

Doi: 10.3390/vaccines12060605

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A novel xylanase from a myxobacterium triggers a plant immune response in Nicotiana benthamiana

Authors: Yuqiang Zhao, Kun Yang, Yanxin Wang, Xu Li, Chengyao Xia, Yan Huang, Zhoukun Li, Cancan Zhu, Zhongli Cui, Xianfeng Ye

Journal: Mol Plant Pathol

PubMed ID: 38924248

Doi: 10.1111/mpp.13488

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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem

Journal: biorxiv

PubMed ID: 38948822

Doi: 10.1101/2024.06.18.599616

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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan

Journal: Stem Cell Res Ther

PubMed ID: 38926849

Doi: 10.1186/s13287-024-03792-3

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A self-healing multispectral transparent adhesive peptide glass

Authors: Gal Finkelstein-Zuta, Zohar A Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit

Journal: Nature

PubMed ID: 38867128

Doi: 10.1038/s41586-024-07408-x

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CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy

Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian

Journal: Blood Adv

PubMed ID: 38564778

Doi: 10.1182/bloodadvances.2023012202

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Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland

Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen

Journal: Microb Biotechnol

PubMed ID: 38829370

Doi: 10.1111/1751-7915.14466

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