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Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans

Authors: Lena Peters, Moritz Drechsler, Michael A Herrera, Jing Liu, Barbara Pees, Johanna Jarstorff, Anna Czerwinski, Francesca Lubbock, Georgia Angelidou, Liesa Salzer, Karlis Arturs Moors, Nicole Paczia, Yi-Ming Shi, Hinrich Schulenburg, Christoph Kaleta, Michael Witting, Manuel Liebeke, Dominic J Campopiano, Helge B Bode, Katja Dierking

Journal: Nature Communications

PubMed ID: 40461452

Doi: 10.1038/s41467-025-60234-1

Products & Services: Gene Synthesis

Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response

Authors: Kenta Matsuda, Mitra Harrison, Eleanor Wettstein, Jessica Pederson, Alyssa A Pullano, Lyuba Bolkhovitinov, Breanna Kim, Isabel Steinberg, Trevor Griesman, Sarah Stuccio, Daniel Rogan, Andy Patamawenu, Tulley Shofner, Nathaniel E Wright, Jonathan D Webber, Freya Van't Veer, Rachel Roenicke, Emma Koory, Peyton M Roeder, Ellison Ober, Benjamin Leach, Yaroslav Tsybovsky, Tyler Stephens, Ivan Del Moral-Sanchez, Ilja Bontjer, Lori W McGinnes-Cullen, Eric Chu, Jason Liang, Jonathan L Torres, Ryan N Lin, Andy S Tran, Gabrielle Dziubla, Leonid Serebryannyy, Sandeep Narpala, Bob Lin, Mike Castro, Gabriel Ozorowski, Andrew B Ward, Rogier W Sanders, Peter D Kwong, Javier Guenaga, Richard Wyatt, Trudy Morrison, Mark Connors

Journal: Nature Communications

PubMed ID: 40461490

Doi: 10.1038/s41467-025-60481-2

Products & Services: Recombinant Proteins

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

Authors: S Arfè, T Karagyozova, A Forest, D Bingham, H Hmidan, D Mazaud, M Garnier, P Le Baccon, E Meshorer, J-P Quivy, G Almouzni

Journal: Nature Communications

PubMed ID: 40461574

Doi: 10.1038/s41467-025-60430-z

Products & Services: Mutagenesis Services

Structural and molecular mechanisms of an Ro60 homolog from a Thermus bacteriophage

Authors: Zetao Hu, Zhaohui Jin, Lulu Guo, Ling Zeng, Xuanjia Dong, Lin Jiang, Wenting Dai, Jinbiao Ma, Ying Huang

Journal: Nucleic Acids Research

PubMed ID: 40464688

Doi: 10.1093/nar/gkaf470

A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent

Authors: Misha Klein, Arnab Das, Subhas C Bera, Thomas K Anderson, Dana Kocincova, Hery W Lee, Bing Wang, Flavia S Papini, John C Marecki, Jamie J Arnold, Craig E Cameron, Kevin D Raney, Irina Artsimovitch, Mathias Götte, Robert N Kirchdoerfer, Martin Depken, David Dulin

Journal: Nucleic Acids Research

PubMed ID: 40464687

Doi: 10.1093/nar/gkaf450

Products & Services: PCR Cloning and Subcloning

Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features

Authors: Jiaxiang Ma, Yu Yang, Ben Pei, Shengli Mi, Zhuo Xiong, Liliang Ouyang

Journal: Advanced Science

PubMed ID: 40464608

Doi: 10.1002/advs.202502367

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Authors: Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei

Journal: Advanced Science

PubMed ID: 40464594

Doi: 10.1002/advs.202414961

Products & Services: Protein Electrophoresis and Western

CPK28-mediated Ca2+ signaling regulates STOP1 localization and accumulation to facilitate plant aluminum resistance

Authors: Yingtang Ma, Hailiang Zheng, Ina Schmitz-Thom, Jiawen Wang, Fanglin Zhou, Chongyang Li, Yaling Zhang, Yiqiu Cheng, Daisuke Miki, Jörg Kudla, Chao-Feng Huang

Journal: Nature Communications

PubMed ID: 40473612

Doi: 10.1038/s41467-025-60427-8

Products & Services: Catalog Antibodies

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses

Authors: Emily A Aunins, Anthony T Phan, Mohamad-Gabriel Alameh, Garima Dwivedi, Elisa Cruz-Morales, David A Christian, Ying Tam, Molly E Bunkofske, Anabel Zabala Peñafiel, Keenan M O'Dea, Maria Merolle, Colleen Furey, Phillip Scott, Robert H Vonderheide, Scott E Hensley, Ross M Kedl, Drew Weissman, Christopher A Hunter

Journal: Science immunology

PubMed ID: 40478935

Doi: 10.1126/sciimmunol.ads1328

O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Authors: Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi-Fai Ng, Jiahua Pan, Wei Xue, Wei-Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu

Journal: Advanced Science

PubMed ID: 40492591

Doi: 10.1002/advs.202504809

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KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis

Authors: Anastasiia Skobelkina, Manon Julien, Sylvain Jeannin, Simona Miron, Tom Egger, Rady Chaaban, Guillaume Bouvignies, Emile Alghoul, Rania Ghouil, Claire Friel, Didier Busso, Juan C Cañas, François-Xavier Theillet, Romain Le Bars, Aura Carreira, Angelos Constantinou, Jihane Basbous, Sophie Zinn-Justin

Journal: Nucleic Acids Research

PubMed ID: 40498077

Doi: 10.1093/nar/gkaf476

Products & Services: Gene Synthesis

ZmSSRP1, transactivated by OPAQUE11, positively regulates starch biosynthesis in maize endosperm

Authors: Long Chen, Chengyun Wu, Quanzhi Li, Ming Du, Yan Li, Beijiu Cheng, Xiaoyu Li, Jiandong Wu

Journal: Plant Biotechnology Journal.

PubMed ID: 40517398

Doi: 10.1111/pbi.70191

Products & Services: Protein and Antibody Isolation

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Authors: Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

Journal: Nature Communications

PubMed ID: 40527873

Doi: 10.1038/s41467-025-60710-8

Products & Services: Mutagenesis Services

A four-in-one replicase integrating key enzymatic activities for DNA replication

Authors: Yuxin Zhang , Xueling Lu , Bin Zhu , Fengtao Huang

Journal: Nucleic Acids Research

PubMed ID: 40548937

Doi: 10.1093/nar/gkaf542

Products & Services: Codon Optimization

PAM-free hairpin target binding activates trans-cleavage activity of Cas12a

Authors: Xiaolong Li, Zixuan Zhu, Jiani Wu, Changjiang Li, Zhujun Liu, Jinjin Wang, Pu Li, Zhen Zhang, Yongming Huang, Jiaxin Hong, Tongbo Wu

Journal: Nucleic Acids Research

PubMed ID: 40557869

Doi: 10.1093/nar/gkaf596

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An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non-heading Chinese Cabbage

Authors: Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren

Journal: Advanced Science

PubMed ID: 40549976

Doi: 10.1002/advs.202414954

Mechanistic studies of small molecule ligands selective to RNA single G bulges

Authors: Shalakha Hegde, Sana Akhter, Zhichao Tang, Chang Qi, Chenguang Yu, Anna Lewicka, Yu Liu, Kushal Koirala, Mikhail Reibarkh, Kevin P Battaile, Anne Cooper, Scott Lovell, Erik D Holmstrom, Xiao Wang, Joseph A Piccirilli, Qi Gao, Yinglong Miao, Jingxin Wang

Journal: Nucleic Acids Research

PubMed ID: 40557870

Doi: 10.1093/nar/gkaf559

Sindbis virus is suppressed in the yellow fever mosquito aedes aegypti by Atg6/BECN1 (autophagy-related 6)-mediated activation of autophagy

Authors: Sujit Pujhari, Chan C Heu, Marco Brustolin, Rebecca M Johnson, Donghun Kim, Jason L Rasgon

Journal: Autophagy

PubMed ID: 40574305

Doi: 10.1080/15548627.2025.2523735

Products & Services: Plasmid DNA Preparation

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Authors: Ya-Zhen Hu, Ting Wang, Chang-Song Wu, Jie Wang, Xue-Qing Han, Yong-An Zhang, Xu-Jie Zhang

Journal: Advanced Science

Doi: 10.1002/advs.202500388

Products & Services: Endotoxin Detection & Removal System

Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

Authors: Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos-Rodriguez, Katherine H. Griffin, Gabriella C. Bond, J. Kent Leach

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202311017

Products & Services: Peptide Synthesis

The scaffold protein RACK1 regulates root growth and gravitropic response by recruiting PINOID to phosphorylate the auxin efflux transporter PIN-FORMED2

Authors: Shujuan Zhang, Qi Liao, Jiale Li, Wenbao Liu, Xinwen Zhang, Xindi Tian, Shucai Wang, Qun Zhang

Journal: Journal of integrative plant biology

PubMed ID: 39912541

Doi: 10.1111/jipb.13858

Products & Services: Catalog Antibodies

Circulating myeloid-derived suppressor cell load and disease severity are associated to an enhanced oligodendroglial production in a murine model of multiple sclerosis

Authors: Mari Paz Serrano-Regal, Celia Camacho-Toledano, Inmaculada Alonso-García, María Cristina Ortega, Isabel Machín-Díaz, Rafael Lebrón-Galán, Jénnifer García-Arocha, Leticia Calahorra, Manuel Nieto-Díaz, Diego Clemente

Journal: Neurobiology of Disease

PubMed ID: 40250717

Doi: 10.1016/j.nbd.2025.106919

Products & Services: Peptide Synthesis

Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides Broad Cross- Reactive Immunity against H9N2 Influenza Virus

Authors: Mengchan Hao, Yanhai Wang, Wenxue Yang, Meng Xu, Yiwei Guan, Yuan Zhang, JianJun Chen

Journal: ACS Nano

PubMed ID: 40452158

Doi: 10.1021/acsnano.5c03199

Products & Services: Endotoxin Detection & Removal System

Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus

Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song

Journal: International Journal of Biological Macromolecules

PubMed ID: 40543771

Doi: doi.org/10.1016/j.ijbiomac.2025.145363

Products & Services: Catalog Peptides

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

Products & Services: Peptide Synthesis

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling

PubMed ID: 40514668

Doi: 10.1186/s12964-025-02289-7

Products & Services: Protein and Antibody Isolation

Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong

Journal: Cellular & molecular immunology

PubMed ID: 40500403

Doi: 10.1038/s41423-025-01305-7

Products & Services: Protein and Antibody Isolation

An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment

Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen

Journal: Acta Biomaterialia

PubMed ID: 40409996

Doi: 10.1016/j.actbio.2025.05.040

Products & Services: Recombinant Proteins

AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

Authors: Keyu Kong, Li Liu, Renfang Zhang, Yongyun Chang, Yueming Shao, Chen Zhao, Hua Qiao, Minghao Jin, Xuzhuo Chen, Wentao Shi, Xinru Wu, Wenxuan Fan, Yuehao Hu, Kewei Rong, Pu Zhang, Baixing Li, Jingwei Zhang, Peixiang Ma, Xiaoling Zhang, Huiwu Li, Zanjing Zhai

Journal: Bone Research

PubMed ID: 40461512

Doi: 10.1038/s41413-025-00431-2

Products & Services: Recombinant Proteins

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Authors: Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne E Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, Christian Grimm, Marja Jäättelä

Journal: Nature Communications

PubMed ID: 40473625

Doi: 10.1038/s41467-025-60349-5

Products & Services: PCR Cloning and Subcloning

The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

Authors: Sara Kassel, Kai Yuan, Nawat Bunnag, Leif R Neitzel, Wenhui Lu, Anna Schwarzkopf, Benjamin Maines, Matthew A Loberg, George Xu, Amber Adams, Andrew D McCray, Alex Cho, Mary Rockouski, Gemma Orton, Lily Goldsmith, Md Mubtaseem Ahnaf Aronno, Zachary T Spencer, Omar M Khan, Fei Ye, Charles Williams, Andres M Lebensohn, Rajat Rohatgi, Xiaofeng Wang, Vivian L Weiss, Charles C Hong, Arminja N Kettenbach, David J Robbins, Yashi Ahmed, Ethan Lee

Journal: Nature Communications

PubMed ID: 40473626

Doi: 10.1038/s41467-025-60535-5

Products & Services: PCR Cloning and Subcloning

Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance

Authors: Reut Tzemach, Chamutal Gur, Truong San Phan, Eyal David, Mor Zada, Merav D Shmueli, Kfir Mazuz, Fadi Sheban, Anna Kurilovich, Maya Ben Yehuda, Victoria Furer, Ari Polachek, Smadar Gertel, Nimrod Snir, Tali Eviatar, Sharon Nevo, Yifat Merbl, Daphna Paran, Shuang-Yin Wang, Ori Elkayam, Ido Amit

Journal: Science immunology

PubMed ID: 40478933

Doi: 10.1126/sciimmunol.adu0284

Products & Services: Protein Electrophoresis and Western

The SH protein of mumps virus is a druggable pentameric viroporin

Authors: Kira Devantier, Trine L Toft-Bertelsen, Andreas Prestel, Viktoria M S Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup, Trond Ulven, Bo H Bentzen, Alexandre Mjj Bonvin, Nanna MacAulay, Birthe B Kragelund, Mette M Rosenkilde

Journal: SCIENCE ADVANCES

PubMed ID: 40479045

Doi: 10.1126/sciadv.ads3071

Products & Services: Bacterial Expression

Antagonistic Ghd7-OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

Authors: Guangming Lou, Pingli Chen, Pingbo Li, Haozhou Gao, Jiawang Xiong, Shanshan Wan, Yuanyuan Zheng, Yufu Wang, Mufid Alam, Yingnanjun Chen, Lei Wang, Jingjing Bai, Xuan Tan, Wenting Rao, Bian Wu, Hao Zhou, Yanhua Li, Guanjun Gao, Qinglu Zhang, Jinghua Xiao, Xianghua Li, Xuelei Lai, Qifa Zhang, Yuqing He

Journal: Advanced Science

PubMed ID: 40492375

Doi: 10.1002/advs.202504163

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Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking

Authors: Akanksha Thawani, Anthony Rodríguez-Vargas, Briana Van Treeck, Nozhat T Hassan, David L Adelson, Eva Nogales, Kathleen Collins

Journal: SCIENCE ADVANCES

PubMed ID: 40540573

Doi: 10.1126/sciadv.adu5533

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Authors: Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li

Journal: Advanced Science

Doi: 10.1002/advs.202501384

Antimicrobial and Potent Anti- Biofilm Properties of Rationally Designed α- Helix Antimicrobial Peptides

Authors: Motasim Ismael, Khayeli Juliah, Madivoli Edwin

Journal: Journal of Peptide Science

PubMed ID: 40326595

Doi: 10.1002/psc.70027

Products & Services: Peptide Synthesis

Control of seed-to-seedling transition by an upstream open reading frame in ABSCISIC ACID DEFICIENT2

Authors: Zhen Wang , Xiaofan Zhang ， Can Zhou , Xiaofeng Cao

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40478869

Doi: 10.1073/pnas.2502155122

Products & Services: Gene Synthesis

Collective Biosynthesis of Plant Spirooxindole Alkaloids through Enzyme Discovery and Engineering

Authors: Danni Chu, Hongkui Wang, Zhiwen Nie, Kang-Li Li, Jiaqing Cao, Meijing Yang, Qin Yin, Yang Gu, Yindi Jiang

Journal: Journal of the American Chemical Society

PubMed ID: 40504680

Doi: 10.1021/jacs.5c02990

Products & Services: Gene Synthesis

Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

Authors: Ding Qiu, Shuishen Zhang, Chanyan Huang, Xinying Wang, Jianping Deng, Haiyang Sun, Bingbing Feng, Ying Tan, Kaile Ji, Shaoting Xu, Xiaoqi Ye, Chao Cheng, Shigeru Kakuta, Yoshiyuki Adachi, Yoichiro Iwakura, Shuai Wang, Shaowei Dong, Ce Tang

Journal: Immunity

PubMed ID: 40494347

Doi: 10.1016/j.immuni.2025.05.007

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Sodium butyrate attenuates lipid metabolism disorder via improving mitochondrial function and activating autophagy in LMH cells

Authors: Sasa Miao, Mengru Xu, Fang Liu, Xinyang Dong, Xiaoting Zou, Tao Zeng, Lizhi Lu

Journal: Poultry Science

Doi: doi.org/10.1016/j.psj.2025.105476

Products & Services: Protein and Antibody Isolation

Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15

Authors: Manashi Sonowal, Gihan Ketawala, Nirupa Nagaratnam, Dhenugen Logeswaran, Shibom Basu, Daniele de Sanctis, Julien Orlans, Samuel L Rose, Rebecca J Jernigan, Hao Hu, Jose Domingo Meza Aguilar, Madurangi E Ranaweera, Michele A Zacks, Julian J-L Chen, Debra T Hansen, Lynn G Schrag, Raimund Fromme, Sabine Botha, Petra Fromme

Journal: Protein Science

PubMed ID: 40411374

Doi: 10.1002/pro.70115

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Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma

Authors: Jie Liu, Yuandong Liu, Dongmin Yin, Yang Tian

Journal: Cell chemical biology

PubMed ID: 40466640

Doi: 10.1016/j.chembiol.2025.05.002

Products & Services: Gene Synthesis

Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy

Authors: Chris van Ewijk, Greeshma Jain, Yari K Knelissen, Sourav Maity, Patrick C A van der Wel, Wouter H Roos

Journal: J Am Chem Soc

PubMed ID: 40505012

Doi: 10.1021/jacs.5c05571

Products & Services: Plasmid DNA Preparation

Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy

Authors: Ilgen Mender , Romina Girotti , Sergei Gryaznov

Journal: Nucleic Acids Research

PubMed ID: 40568934

Doi: 10.1093/nar/gkaf591

Products & Services: Protein Electrophoresis and Western

Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

Authors: Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu

Journal: Advanced Science

Doi: 10.1002/advs.202504965

Products & Services: Peptide Synthesis

And then, proteins were resolved in 4–12% Bis-Tris SurePAGE gel (Genscript) and transferred to 0.45 µm PVDF membrane (Millipore) for blotting.

Authors: Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing

Journal: Advanced Science

Doi: 10.1002/advs.202502723

Products & Services: Codon Optimization

Designing Sandwich ELISA with Broadly Reactive Anti-Nucleocapsid Monoclonal Antibodies to Detect Bat-Borne Merbecoviruses

Authors: Kong Yen Liew, Yaju Wang, Sneha Sree Mullapudi, Dinah Binte Aziz, Wenjie Fan, Min Luo, Paul Anantharajah Tambyah, Yee-Joo Tan

Journal: Viruses

PubMed ID: 40733504

Doi: 10.3390/v17070886

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning

Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

Authors: Guillaume Mas , Sebastian Hiller

Journal: Nature Communications

PubMed ID: 40449998

Doi: 10.1038/s41467-025-60343-x

Products & Services: Gene Synthesis

Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization

Authors: Eliott S Wenger, David W Christianson

Journal: Nature Communications

PubMed ID: 39677668

Doi: 10.1101/2024.12.03.626647

Products & Services: Custom Vector Construction

Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Authors: Virginia Tajadura-Ortega, Wengang Chai, Lauren A Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C Decout, Benedita A Pinheiro, Angelina S Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R D Costa, Himani Amin, Lynne Sykes, Phillip R Bennett, Julian R Marchesi, Ten Feizi, Yan Liu, David A MacIntyre

Journal: Nature Communications

PubMed ID: 40467588

Doi: 10.1038/s41467-025-60404-1

Products & Services: PCR Cloning and Subcloning

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Authors: Grace Neilsen, Shuiyun Lan, Ryan L Slack, Zachary C Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G Edwards, Huanchun Zhang, Jasper Lee, William A Cantara, Maria E Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R Tedbury, Karen A Kirby, Raymond F Schinazi, Stefan G Sarafianos

Journal: SCIENCE ADVANCES

PubMed ID: 40479048

Doi: 10.1126/sciadv.adv8875

Products & Services: PCR Cloning and Subcloning

RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

Authors: Akihito Sakoguchi, Samuel G Chamberlain, Alexander M Mørch, Marcus Widdess, Thomas E Harrison, Michael L Dustin, Hisashi Arase, Matthew K Higgins, Shiroh Iwanaga

Journal: Nature

PubMed ID: 40500441

Doi: 10.1038/s41586-025-09091-y

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Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation

Authors: Guillem Hernandez, Maria L Martins, Nuno P Fernandes, Tiago Veloso, João Lopes, Tiago Gomes, Tiago N Cordeiro

Journal: Nucleic Acids Research

PubMed ID: 40503686

Doi: 10.1093/nar/gkaf502

Identification of a gene conferring broad-spectrum orthotospovirus resistance in Solanaceae

Authors: Yong Liu, Jie Wang, Chongkun Zuo, Weishu Fan, Cheng Yuan, Jianmin Zeng, Haiqin Yu, Zhijun Tong, Xueyi Sui, Yi Xu, Min Zhu, Xiaorong Tao, Jiongjiong Chen, Hanhui Kuang, Polina Yu Novikova, Changjun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40532009

Doi: 10.1126/sciadv.adw4333

Products & Services: Gene Synthesis

In vitro programmable DNA cleavage by a eukaryotic Argonaute

Authors: Guangbo Yan, Xia Li, Longyu Wang, Fei Wang, Siyuan Lv, Xiaolan Yu, Zhongchen Li, Jiakai Cui, Baotong Sun, Jia Hou, Wenqiang Li, Xiaochen Xie, Shuai Zhao, Zhiwei Zhang, Wanping Chen, Yanhong Peng, Yang Liu, Lixin Ma

Journal: Nucleic Acids Research

PubMed ID: 40548933

Doi: 10.1093/nar/gkaf561

UniClo: scarless hierarchical DNA assembly without sequence constraint

Authors: Carol N Flores-Fernández , Da Lin , Katherine Robins , Chris A O'Callaghan

Journal: Nucleic Acids Research

PubMed ID: 40548934

Doi: 10.1093/nar/gkaf548

Products & Services: PCR Cloning and Subcloning

NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence

Authors: Zheng Dai, Feng Liu, Miaodeng Liu, Yuqi Song, Hongyan Zhang, Cheng Zhou, Wenyu Liu, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang

Journal: Bioactive Materials

Doi: https://doi.org/10.1016/j.bioactmat.2025.06.037

Products & Services: Catalog Peptides

Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePt Dual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis

Authors: Qianglan Lu, Chengwei Ye, Wei Mao, Fei Zeng, Zhiyong Liu, Ruiyue Chen, Xiao Cheng, Yanfeng Gao, Meng Wang, Mei Liu, Shaochun Tang, Yujun Song

Journal: ACS Nano .

PubMed ID: 40532220

Doi: 10.1021/acsnano.5c04686

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Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

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Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Authors: Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu & Haipeng Gong

Journal: Nature Machine Intelligence

Doi: doi.org/10.1038/s42256-025-01059-x

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Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

Authors: Shruthi Krishnaswamy, Shirin Akbar, Daniel S D Larsson, Yang Chen, Maria Selmer

Journal: Nature Communications

PubMed ID: 40571681

Doi: 10.1101/2024.12.14.628468

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OsPRMT6b balances plant growth and high temperature stress by feedback inhibition of abscisic acid signaling

Authors: Xin Jin, Qibing Lin, Xinyue Zhang, Shuang Zhang, Weiwei Ma, Peike Sheng, Limin Zhang, Minxi Wu, Xudong Zhu, Zhiwei Li, Bojuan Liu, Jiachang Wang, Yupeng Wang, Kun Dong, Ming Yu, Yulong Ren, Zhijun Cheng, Cailin Lei, Xiuping Guo, Xin Wang, Haiyang Wang, Fu-Qing Wu, Shanshan Zhu, Jianmin Wan

Journal: Nature Communications

PubMed ID: 40467572

Doi: 10.1038/s41467-025-60350-y

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Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector

Authors: Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K Aggarwal

Journal: Nature Communications

PubMed ID: 40473611

Doi: 10.1038/s41467-025-60484-z

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β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1

Authors: Yin Li, Jie Fang, Yuqi Ding, Xilong Zhang, Ying Liu, Wanting Qiu, He Xu, Yunzhe Kang, Jiayu Chen, Yanyan Gao, Yan G Zhao, Peiguo Yang, Bo Wang, Wenmin Tian, Yang Chen, Wenjian Bi, Peipei Zhang

Journal: Nature Communications

PubMed ID: 40473629

Doi: 10.1038/s41467-025-60583-x

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An Engineered Soluble Single-Chain TCR Engager for KRAS-G12V Specific Tumor Immunotherapy

Authors: Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W H Zhang, Xiaopeng Ma, Hui Tan, George F Gao, Shuguang Tan

Journal: Advanced Science

PubMed ID: 40470869

Doi: 10.1002/advs.202500181

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GhTOPP4aD and GhRAF36 inversely regulate cotton (Gossypium hirsutum) response to ABA and salt stress through reversible phosphorylation of GhABI1

Authors: Pengfei Cao, Lin Zhou, Mingwei Du, Xiaoli Tian, Fangjun Li, Zhaohu Li

Journal: Plant Biotechnology Journal.

PubMed ID: 40483577

Doi: 10.1111/pbi.70166

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Deciphering the role of accessory proteins in Arabidopsis chloroplast editosomes via interaction with a synthetic PPR-PLS factor in E. coli

Authors: Jose M Lombana , Maureen R Hanson , Stéphane Bentolila

Journal: Nucleic Acids Research

PubMed ID: 40498070

Doi: 10.1093/nar/gkaf483

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Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III

Authors: Conor James McClune, Jack Chun-Ting Liu, Chloe Wick, Ricardo De La Peña, Bernd Markus Lange, Polly M Fordyce, Elizabeth S Sattely

Journal: Nature

PubMed ID: 40500440

Doi: 10.1038/s41586-025-09090-z

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Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R

Authors: Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Franziska M Heydenreich, Tilman Flock, Bianca Plouffe, Christian Le Gouill, Jean Duchaine, David A Sykes, Colin Nicholson, Eline J Koers, Wolfgang Guba, Arne C Rufer, Uwe Grether, Michel Bouvier, Dmitry B Veprintsev, Jana Selent

Journal: Nature Communications

PubMed ID: 40500255

Doi: 10.1038/s41467-025-60003-0.

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mRNA-LNP vaccines against hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models

Authors: María José Limeres, Rocio Gambaro, Malin Svensson, Silvia Fraude-El Ghazi, Leah Pretsch, Daniel Frank, German A Islan, Ignacio Rivero Berti, Matthias Bros, Ying K Tam, Hiromi Muramatsu, Norbert Pardi, Stephan Gehring, Maximiliano L Cacicedo

Journal: Molecular Therapy

PubMed ID: 40518670

Doi: 10.1016/j.ymthe.2025.06.027

ELD1 mediates photoperiodic flowering via OsCCA1 alternative splicing and interacts with phytochrome signaling in rice

Authors: Liang Cai, Benyuan Hao, Zhuang Xu, Song Cui, Qianyun Wu, Jiyoung Lee, Haigang Hou, Yuan Hu, Liang Zhu, Jie Wang, Wen Li, Kongyou Chang, Weihao Shao, Shanshan Zhu, Xiangchao Gan, Chao Li, Ling Jiang, Yunlu Tian, Xi Liu, Shijia Liu, Liangming Chen, Haiyang Wang, Shirong Zhou, Jianmin Wan

Journal: Nature Communications

PubMed ID: 40537466

Doi: 10.1038/s41467-025-60839-6

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Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking

Authors: Esther González-Almela, Alvaro Castells-Garcia, François Le Dily, Manuel Fernández Merino, Davide Carnevali, Pol Cusco, Luciano Di Croce, Maria Pia Cosma

Journal: Nature Communications

PubMed ID: 40537528

Doi: 10.1038/s41467-025-60534-6

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Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5

Authors: Wen-An Wang, Evandro Ferrada, Christoph Klimek, Tanja Osthushenrich, Aidan MacNamara, Tabea Wiedmer, Giulio Superti-Furga

Journal: SCIENCE ADVANCES

PubMed ID: 40577459

Doi: 10.1126/sciadv.adx3011

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Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

Authors: Shixian Tao, Wei He, Chuntong Li, Jiawei Liang, Zebin Tong, Zhiheng Deng, Liying Zhang, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Science China-Chemistry

Doi: 10.1007/s11426-025-2697-6

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A MERS-CoV-like mink coronavirus uses ACE2 as an entry receptor

Authors: Ningning Wang, Weiwei Ji, Houqi Jiao, Michael Veit, Ju Sun, Yanjun Wang, Xing Ma, Yu Wang, Yutong Wang, Xin-Xin Li, Xiaoguang Zhang, Jie Chen, Jiayu Wei, Ying Xu, Dawei Guo, Xiaofeng Zhai, Andres Merits, Chang Li, Félix A Rey, Georgi M Dobrikov, George F Gao, Shuijun Zhang, Yuhai Bi, Shuo Su

Journal: Nature

PubMed ID: 40306315

Doi: 10.1038/s41586-025-09007-w

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A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display

Authors: Carla Tomatis, Mara C A M Aguiar, Nancy Charo, Silvia Aquila, Pablo D Thomas, Paula N Arrías, Matías L Pidre, Víctor Romanowski, Laura Riera, Julia Brignone, Andrea Maiza, Eugenio Antonio Carrera Silva, María Florencia Ferrer, Ricardo Martín Gómez

Journal: Current Microbiology

PubMed ID: 40514553

Doi: 10.1007/s00284-025-04320-z

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Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

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Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

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YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

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RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

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Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

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Constitutive down-regulation of liguleless alleles in sorghum drives increased productivity and water use efficiency

Authors: Nikhil Jaikumar, Truyen Quach, Zhengxiang Ge, Natalya Nersesian, Shirley J Sato, Scott M McCoy, Ming Guo, Andrew D B Leakey, Stephen P Long, Tom Elmo Clemente

Journal: Plant Biotechnology Journal.

PubMed ID: 40452217

Doi: 10.1111/pbi.70150

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Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

Authors: Chung-Yao Hsu, Po-Cheng Tsai, Jung-Chen Lin, Chen-Hsueh Pai, Yun-Jui Teng, Bing-Yu Yao, Cheng-Yin Fei, Gwo Harn Max Shiau, Leon Cw Lin, Sean Lo, Hung-Chih Yang, Che-Ming Jack Hu

Journal: Nature Communications

PubMed ID: 40456725

Doi: 10.1038/s41467-025-60321-3

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De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

Authors: Wenfeng Zhao, Guofeng Chen, Jian He, Xiaofang Shen, Muya Xiong, Liwei Xiong, Zhihao Qi, Hang Xie, Wanchen Li, Jiameng Li, Huixia Dou, Hangchen Hu, Haixia Su, Qiang Shao, Minjun Li, Hongbin Sun, Yechun Xu

Journal: Nature Communications

PubMed ID: 40461475

Doi: 10.1038/s41467-025-60297-0

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Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase

Authors: Bo He, Yanhao Hu, Dongshan Liu, Xin Zang, Xu He, Wang Chen, Jingfang Yang, Mingfeng Feng, Ping Chen, Lirong Wei, Yu Li, Wei Yan, Jun Li, Zhike Feng, Jiahai Zhou, Yonghao Ye

Journal: Nature Communications

PubMed ID: 40467578

Doi: 10.1038/s41467-025-60489-8

Functional relocation of the maize chloroplast atpB gene to the nucleus restores photosynthetic competence to a gene-edited non-photosynthetic mutant

Authors: Venkata RamanaRao Mangu, Kelsey Jenkins, Anna Pratt, Kara A Boltz, Leila Pazouki, Alice Y Hui, Muruganantham Mookkan, Jeffrey M Staub

Journal: Plant Biotechnology Journal.

PubMed ID: 40467523

Doi: 10.1111/pbi.70175

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Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa

Authors: Marius Benedens, Cristian Rosales-Hernandez, Sabine A P Straathof, Jennifer Loschwitz, Otto Berninghausen, Giovanni Maglia, Roland Beckmann, Alexej Kedrov

Journal: Nature Communications

PubMed ID: 40473691

Doi: 10.1038/s41467-025-60605-8

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Single-Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Authors: Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu

Journal: Advanced Science

PubMed ID: 40470730

Doi: 10.1002/advs.202500216

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Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity

Authors: Hwa Young Kim, Gi Young Lee, Andrew J Thompson, Ryan McBride, Dah-Jiun Fu, James C Paulson, Jeongmin Song

Journal: SCIENCE ADVANCES

PubMed ID: 40479051

Doi: 10.1126/sciadv.adt2040

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The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in Drosophila

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel K Smith-Bolton

Journal: SCIENCE ADVANCES

PubMed ID: 40479065

Doi: 10.1126/sciadv.ads5743

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Chemokines kill bacteria without triggering antimicrobial resistance by binding anionic phospholipids

Authors: Sergio M Pontejo, Sophia Martinez, Allison Zhao, Kevin Barnes, Jaime de Anda, Haleh Alimohamadi, Ernest Y Lee, Acacia F Dishman, Brian F Volkman, Gerard C L Wong, David N Garboczi, Angela Ballesteros, Philip M Murphy

Journal: SCIENCE ADVANCES

PubMed ID: 40479071

Doi: 10.1126/sciadv.ads2675

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ATP13A1 engages SEC61 to facilitate substrate-specific translocation

Authors: Xiaoyan Yang, Yi Li, Chengxi Yang, Tingting Li, Zhiyu Fang, Zhigang Feng, Jun Liao, Yan Zou

Journal: SCIENCE ADVANCES

PubMed ID: 40498833

Doi: 10.1126/sciadv.adt1346

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Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer

Authors: Ze Mi, Juan Chen, Zhewen Zhang, Jiahao Liu, Yiyi Lei, Hongpei Tan, Wei Li, Xiaoyuan Chen, Pengfei Rong

Journal: SCIENCE ADVANCES

PubMed ID: 40531967

Doi: 10.1126/scitranslmed.ado8395

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HIV-1 binds dynein directly to hijack microtubule transport machinery

Authors: Somayesadat Badieyan, Drew Lichon, Sevnur Komurlu Keceli, Michael P Andreas, John P Gillies, Wang Peng, Jiong Shi, Morgan E DeSantis, Christopher R Aiken, Till Böcking, Tobias W Giessen, Edward M Campbell, Michael A Cianfrocco

Journal: SCIENCE ADVANCES

PubMed ID: 40532013

Doi: 10.1126/sciadv.adn6796

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

Authors: Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren

Journal: SCIENCE ADVANCES

PubMed ID: 40540557

Doi: 10.1126/sciadv.adw0698

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Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap-DNAs and Alleviating Pulmonary Fibrosis

Authors: Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen

Journal: Advanced Science

PubMed ID: 40539399

Doi: 10.1002/advs.202505357

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate

Authors: Fan Chen, Xue-Fei Tian, Teng Yang, Yu-Jie Dai, Da-Yuan Chen, Hong-Bo Chen, Takaya Shimura, Xin-Fang Li, Chu-Lin Sha, Qing Ji, Jun Cao, Mei-Yu Fang, Jin-Biao Shang, Jian-Min Fang, Ye Lu, Wei-Hui Zheng, Peng Guo, Wei-Hong Tan

Journal: Advanced Science

PubMed ID: 40539828

Doi: 10.1002/advs.202504851

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Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage

Authors: Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing

Journal: Advanced Science

PubMed ID: 40548893

Doi: 10.1002/advs.202409307

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Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication

Authors: Klara Lenart, Hendrik Feuerstein, Mariana Prado Marmorato, Laura Perez Vidakovics, Gerald McInerney, Mimi Guebre-Xabier, Jessica F Trost, Bengt Eriksson, Gale Smith, Nita Patel, Karin Loré

Journal: Nature Communications

PubMed ID: 40562777

Doi: 10.1038/s41467-025-60885-0

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