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Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia

Authors: Rui-Jin Ji , Guo-Hua Cao , Wei-Qiang Zhao , Mu-Yao Wang , Pan Gao, Yi-Zhou Zhang, Xue-Bin Wang, Hou-Yuan Qiu , Di-Di Chen, Xiao-Han Tong , Min Duan, Hao Yin, Ying Zhang

Journal: Cell Stem Cell

PubMed ID: 39353428

Doi: 10.1016/j.stem.2024.09.003

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Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy

Authors: Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202408767

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Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1–RNA interaction

Authors: Yang Tan , Zhibo Zhao , Qingfang Han , Peipei Xu , Xiaopeng Shen , Yajun Jiang , Qiang Xu , Xingxin Wu

Journal: Nucleic Acids Research

PubMed ID: 39268573

Doi: 10.1093/nar/gkae788

Products & Services: Plasmid DNA Preparation

Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice

Authors: Jia He , Chaoyu Wang , Xiao Fang , Junyao Li , Xueying Shen , Junxia Zhang , Cheng Peng , Hongjian Li , Sai Li , Jeffrey M Karp , Rui Kuai

Journal: Nature Communications

PubMed ID: 39284814

Doi: 10.1038/s41467-024-52104-z

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Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase

Authors: Elżbieta Wątor, Piotr Wilk, Paweł Kochanowski, Przemysław Grudnik

Journal: FEBS J

Doi: doi.org/10.1111/febs.17207

Products & Services: Gene Synthesis

Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

Authors: Zongyou Pan, Kaiwang Xu, Guanrui Huang, Haoran Hu, Huang Yang, Haotian Shen, Kaijie Qiu, Canlong Wang, Tengjing Xu, Xinning Yu, Jinhua Fang, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Chuyue Sun, Zhaopeng Tang, Shiyao Liao, Guang Yang, Zhiyuan You, Xuesong Dai, Zhengwei Mao

Journal: Advanced Materials

PubMed ID: 39081086

Doi: 10.1002/adma.202407115

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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

Authors: Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, Ziyu Luo, Tongyun Wang, Bo Qin, Shuofeng Yuan, Xiaopan Gao, Wenyi Mi, Sheng Cui

Journal: Acta Pharmaceutica Sinica B

PubMed ID: 39309499

Doi: doi.org/10.1016/j.apsb.2024.05.018

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Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity

Authors: Lulu Ren , Jianqin Wan , Xiaoyan Li , Jie Yao , Yan Ma , Fanchao Meng , Shusen Zheng , Weidong Han , Hangxiang Wang

Journal: Nature Communications

PubMed ID: 39227567

Doi: 10.1038/s41467-024-51945-y

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Antimony Component Schottky Nanoheterojunctions as UltrasoundHeightened Pyroptosis Initiators for Sonocatalytic Immunotherapy

Authors: Jihu Nie, Nailin Yang , Shumin Sun , Li Wang , Zifan Pei, Jie Wu, Qiao Yu, Zhihui Han ,Youdong Chen , Liang Cheng

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39305135

Doi: 10.1002/anie.202416426

Products & Services: Proteins, Expression, Isolation and Analysis

EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection

Authors: Yuege Huang , Hong Mei , Chunchen Deng , Wei Wang , Chao Yuan , Yan Nie , Jia-Da Li , Jia Liu

Journal: Nature Communications

PubMed ID: 39231976

Doi: 10.1038/s41467-024-52193-w

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid generation of long, chemically modified pegRNAs for prime editing

Authors: Xinlin Lei , Anhui Huang , Didi Chen , Xuebin Wang , Ruijin Ji , Jinlin Wang , Yizhou Zhang , Yuming Zhang , Shuhan Lu , Kun Zhang , Qiubing Chen , Ying Zhang , Hao Yin

Journal: Nature Biotechnology

PubMed ID: 39349835

Doi: doi.org/10.1038/s41587-024-02394-x

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A bioorthogonal probiotic platform spatiotemporally releases nanobodies in deep tumor for cancer chemoimmunotherapy

Authors: Ruiyue Chen , Qianglan Lu , Fei Zeng , Shurong Qin , Yongchun Pan , Zhiyong Liu , Yuzhen Wang , Bangshun He , Wenjin Qi , Yujun Song

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.09.002

Products & Services: Recombinant Proteins

Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and aPD-L1 for Glioblastoma Immunotherapy

Authors: Lei Dong , Yini Zhu , Haoge Zhang , Lin Gao , Zhiqi Zhang , Xiaoxuan Xu , Leqian Ying , Lu Zhang , Yue Li , Zhengcheng Yun , Danqi Zhu , Chang Han , Tingting Xu , Hui Yang , Shenghong Ju , Xiaoyuan Chen , Haijun Zhang , Jinbing Xie

Journal: ADVANCED MATERIALS

PubMed ID: 39264011

Doi: 10.1002/adma.202407235

Products & Services: Recombinant Proteins

Strontium-Modified porous attapulgite composite hydrogel scaffold with advanced angiogenic and osteogenic potential for bone defect repair

Authors: Chun Liu , Su Ni , Xiaoyu Wu , Linxiang Zhang , Ting Dai , Aiqin Wang , Hongbin Zhao

Journal: COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

Doi: doi.org/10.1016/j.compositesa.2024.108492

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of antimicrobial bioactive peptides from the camel milk protein lactoferrin: Molecular docking, molecular dynamic simulation, and in vitro study

Authors: Mohammed Alzain , Ehab M.M. Ali , Mazin Zamzami , Ishtiaq Qadri , Hani Choudhry , Kamel Chaieb , Bochra Kouidhi , Hisham N. Altayb

Journal: food and humanity

Doi: doi.org/10.1016/j.foohum.2024.100414

Products & Services: Peptide Synthesis

Diffusiophoresis promotes phase separation and transport of biomolecular condensates

Authors: Viet Sang Doan , Ibraheem Alshareedah , Anurag Singh , Priya R Banerjee , Sangwoo Shin

Journal: Nature Communications

PubMed ID: 37461689

Doi: 10.1038/s41467-024-51840-6

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AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution

Authors: Yumiao Gao, Siran Zhu, Huichun Li, Xueting Hao, Wen Chen, Deng Pan, Zhikang Qian

Journal: BRIEFINGS IN BIOINFORMATICS

PubMed ID: 39400114

Doi: 10.1093/bib/bbae468

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Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks

Authors: Li Chen , Minqing Liu , Yupeng Li , Yan Guan, Jiaqi Ruan , Zhilei Mao , Wenxiu Wang , Hong-Quan Yang , Tongtong Guo

Journal: BBRC

Doi: 10.1016/j.bbrc.2024.150233

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The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress

Authors: Ying Ma , Jiarong Guo , Haipeng Rao , Jingyu Xin , Xinyi Song , Rui Liu , Shan Shao , Jiajia Hou , Liyu Kong , Zhigang Hu , Lingfeng He , Feiyan Pan , Zhigang Guo

Journal: Journal of extracellular vesicles

PubMed ID: 39235072

Doi: 10.1002/jev2.12505

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Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

Authors: Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He

Journal: Nature Cell Biology

PubMed ID: 39300312

Doi: 10.1038/s41556-024-01499-4

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Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA

Authors: Hongzhan Xu , Jing Ye # , Kui-Xing Zhang # , Qingxi Hu , Tongxiao Cui , Chong Tong , Mengqi Wang , Huichao Geng , Kun-Ming Shui , Yan Sun , Jian Wang , Xiaomeng Hou , Kai Zhang , Ran Xie , Yafei Yin , Nan Chen , Jia-Yu Chen

Journal: nature Chemistry

PubMed ID: 39223307

Doi: 10.1038/s41557-024-01609-7

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OsFAD1–OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice

Authors: Mingxing Cheng , Huanran Yuan , Ruihua Wang , Fengfeng Fan , Fengfeng Si , Xiong Luo , Wei Liu , Shaoqing Li

Journal: Journal of integrative plant biology

PubMed ID: 39279451

Doi: doi.org/10.1111/jipb.13775

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OsGRF6-OsYUCCA1/OsWRKY82 Signaling Cascade Upgrade Grain Yield and Bacterial Blight Resistance in Rice

Authors: Huanran Yuan, Mingxing Cheng, Fengfeng Fan , Xingfei Zheng , Ruihua Wang , Fengfeng Si , Xiong Luo, Nengwu Li 1, Shaoqing Li

Journal: Advanced Science

PubMed ID: 38923395

Doi: 10.1002/advs.202407733

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Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes

Authors: Yani Arhab , Tatyana V Pestova , Christopher U T Hellen

Journal: Viruses

PubMed ID: 39339889

Doi: 10.3390/v16091413

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Discovery of alkaline laccases from basidiomycete fungi through machine learning-based approach

Authors: Xing Wan, Sazzad Shahrear, Shea Wen Chew, Francisco Vilaplana, Miia R Mäkelä

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 39261970

Doi: 10.1186/s13068-024-02566-6

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A two-pronged nanostrategy of iron metabolism disruption to synergize tumor therapy by triggering the paraptosis-apoptosis hybrid pathway

Authors: Huali Lei , Guanghui Hou , Lin Liu , Zifan Pei , Youdong Chen , Yujie Lu , Nalin Yang , Shumin Sun , Liang Cheng

Journal: ACS Nano

PubMed ID: 39121010

Doi: 10.1021/acsnano.4c06199

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25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism

Authors: Yamei Dang , Yuan Wang , Jing Wei , Hui Zhang , Qiqi Yang , Bin Wang , Jia Li , Chuantao Ye , Yang Chen , Peijun Han , Xiaolei Jin , Jia Wang , Xiaohui Bao , He Liu , Hongwei Ma , Liang Zhang , Linfeng Cheng , Yangchao Dong , Yinlan Bai , Yinghui Li , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: FREE RADICAL BIOLOGY AND MEDICINE

PubMed ID: 39209137

Doi: 10.1016/j.freeradbiomed.2024.08.029

Products & Services: Codon Optimization

Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

Authors: Pheonah Badu , Gabriele Baniulyte , Morgan A Sammons , Cara T Pager

Journal: Virology Journal

PubMed ID: 39212382

Doi: 10.1128/jvi.01055-24

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Reduced Cross-Protective Potential of Omicron Compared to Ancestral SARS-CoV-2 Spike Vaccines Against Potentially Zoonotic Coronaviruses

Authors: Tyler RennerMatthew StuibleBrian CassSylvie PerretJulie GuimondSimon Lord-DufourMichael J. McCluskieYves DurocherBassel Akache

Journal: npj Viruses

Doi: doi.org/10.21203/rs.3.rs-4791122/v1

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Transcription elongation of the plant RNA polymerase IV is prone to backtracking

Authors: Chengli Fang, Kun Huang, Xiaoxian Wu, Hongwei Zhang, Zhanxi Gu, Jiawei Wang, Yu Zhang

Journal: Science Advances

PubMed ID: 39178250

Doi: 10.1126/sciadv.adq3087

Products & Services: Proteins, Expression, Isolation and Analysis

A maternal brain hormone that builds bone

Authors: Muriel E Babey, William C Krause, Kun Chen, Candice B Herber, Zsofia Torok, Joni Nikkanen, Ruben Rodriguez, Xiao Zhang, Fernanda Castro-Navarro, Yuting Wang, Erika E Wheeler, Saul Villeda, J Kent Leach, Nancy E Lane, Erica L Scheller, Charles K F Chan, Thomas H Ambrosi, Holly A Ingraham

Journal: Nature

PubMed ID: 38987585

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Preparation of polyclonal antibody against thrombospondin 2 recombinant protein and its functional verification in pulmonary hypertension syndrome in broilers

Authors: Wen Peng, Chenxi Jiang, Gaofeng Cai, Liling Liu, Xiaoquan Guo, Xiaona Gao, Guyue Li, Zhanhong Zheng, Pei Liu, Ping Liu

Journal: International Journal of Biological Macromolecules

PubMed ID: 38906344

Doi: doi.org/10.1016/j.ijbiomac.2024.133284

Products & Services: Proteins, Expression, Isolation and Analysis

Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

Authors: Jennifer E Gilda, Asrafun Nahar, Dharanibalan Kasiviswanathan, Nadav Tropp, Tamar Gilinski, Tamar Lahav, Dina Alexandrovich, Yael Mandel-Gutfreund, Soyeon Park, Shenhav Shemer

Journal: J Cell Biol

PubMed ID: 38767572

Doi: 10.1083/jcb.202402046

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

Authors: Cheng Zhang , Hong-Ming Ma , Shuai Wu , Jia-Ming Shen , Na Zhang , Yi-Lu Xu , Cheng-Xiao Li , Ping He , Meng-Kai Ge , Xi-Li Chu , Yu-Xue Zhang , Jun-Ke Zheng , Guo-Qiang Chen , Shao-Ming Shen

Journal: Developmental Cell

PubMed ID: 39197453

Doi: 10.1016/j.devcel.2024.08.003

Products & Services: Proteins, Expression, Isolation and Analysis

Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels

Authors: Yuanyue Shan , Mengmeng Zhang , Meiyu Chen , Xinyi Guo , Ying Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39209849

Doi: 10.1038/s41467-024-51800-0.

Products & Services: Proteins, Expression, Isolation and Analysis

Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation

Authors: Nicoletta Cieri 1 2 3, Nidhi Hookeri 1 2 4, Kari Stromhaug 1 2, Liang Li 2, Julia Keating 4, Paula Díaz-Fernández 5, Valle Gómez-García de Soria 6, Jonathan Stevens 7, Raphael Kfuri-Rubens 1 2, Yiren Shao 1 2 4, Kameron A Kooshesh 3, Kaila Powell 1, Helen Ji 1, Gabrielle M Hernandez 2, Jennifer Abelin 2, Susan Klaeger 2 8, Cleo Forman 1 4, Karl R Clauser 2, Siranush Sarkizova 2, David A Braun 1 2 3 9 10, Livius Penter 1 2 3 11, Haesook T Kim 4, William J Lane 3 7, Giacomo Oliveira 1 2 3, Leslie S Kean 3 12, Shuqiang Li 1 13, Kenneth J Livak 1 13, Steven A Carr 2, Derin B Keskin 1 2 3 13 14 15, Cecilia Muñoz-Calleja 5 16, Vincent T Ho 1 3 9, Jerome Ritz 1 3 9, Robert J Soiffer 1 3 9, Donna Neuberg 4, Chip Stewart 2, Gad Getz 2 3 17 18, Catherine J Wu 19 20 21 22

Journal: Nat Biotechnol

PubMed ID: 39169264

Doi: 10.1038/s41587-024-02348-3

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A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity

Authors: Zifan Pei , Nan Jiang , Fei Gong , Weihao Yang , Jiachen Xu , Bin Yu , Nailin Yang , Jie Wu , Huali Lei , Shumin Sun , Longxiao Li , Zhicheng Liu , Caifang Ni , Liang Cheng

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.07.013

Products & Services: Proteins, Expression, Isolation and Analysis

hypocretin-1/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model

Authors: Bing Chen , Kangyu Jin , Jingyi Dong , Shangping Cheng , Lingzhuo Kong , Shaohua Hu , Zuobing Chen, Jing Lu

Journal: Advanced Science

PubMed ID: 39119889

Doi: 10.1002/advs.202405354

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A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection

Authors: Qishan Wang , Yuehong Wang , Yihao Liu , Kai Yuan , Yixuan Lin , Xian Qian , Hongyan Pei , Liangliang Weng , Kaijian Fan , Yihe Hu , Yiqi Yang

Journal: Carbohydrate Polymers

Doi: 10.1016/j.carbpol.2024.122659

Products & Services: Proteins, Expression, Isolation and Analysis

Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination

Authors: Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia

Journal: Journal of controlled release

PubMed ID: 39153722

Doi: 10.1016/j.jconrel.2024.08.025.

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Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Authors: Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao

Journal: Cell death & disease

PubMed ID: 39097608

Doi: 10.038/s41419-024-06941-x

Products & Services: Proteins, Expression, Isolation and Analysis

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice

Authors: Yi Ding 1, Qiu-Bing Chen , Hui Xu , Dilare Adi , Yi-Wen Ding , Wen-Jun Luo , Wen-Zhuo Zhu , Jia-Chen Xu , Xiaolu Zhao , Xiong-Jie Shi , Jie Luo , Hao Yin , Xiao-Yi Lu

Journal: Journal of lipid research

PubMed ID: 39173829

Doi: 10.1016/j.jlr.2024.100626

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Channelrhodopsins with distinct chromophores and binding patterns

Authors: Yuanyue Shan , Liping Zhao , Meiyu Chen , Xiao Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39181878

Doi: 10.1038/s41467-024-51811-x

Products & Services: Proteins, Expression, Isolation and Analysis

Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism

Authors: Camila Cimadamore-Werthein , Martin S King , Denis Lacabanne , Eva Pyrihová , Stephany Jaiquel Baron , Edmund Rs Kunji

Journal: EMBO J

PubMed ID: 38937634

Doi: 10.1038/s44318-024-00150-0.

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Anattachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection

Authors: Dan Zhou , Rao Cheng , Yanfeng Yao , Gan Zhang , Xin Li , Bingjie Wang , Yong Wang , Feiyang Yu , Shangyu Yang , Hang Liu , Ge Gao , Yun Peng , Miaoyu Chen , Zengqin Deng , Haiyan Zhao

Journal: npj Vaccines

PubMed ID: 39217188

Doi: 10.1038/s41541-024-00954-5

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Cellular N-Myristoyl Transferases Are Required for Mammarenavirus Multiplication

Authors: Haydar Witwit , Carlos Alberto Betancourt , Beatrice Cubitt , Roaa Khafaji , Heinrich Kowalski , Nathaniel Jackson , Chengjin Ye , Luis Martinez-Sobrido , Juan C de la Torre

Journal: Viruses

PubMed ID: 39339839

Doi: 10.3390/v16091362

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Dynamics and implications of anti-drug antibodies against adalimumab using ultra-sensitive and highly drug-tolerant assays

Authors: Xiaoliang Ding, Ling Xue, Mingjun Wang, Shengxiong Zhu, Kouzhu Zhu, Sheng Jiang, Jian Wu, Liyan Miao

Journal: Frontiers in Immunology

PubMed ID: 39238635

Doi: 10.3389/fimmu.2024.1429544

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A Ubiquitin-Competitive Strategy Based on the Element Microenvironment toTreat Osteoarthritis

Authors: Keyu Kong, Yuqi Yang, Yongyun Chang, Youdong Chen, Xiao Yang, Jiahao Qin, Zhuorun Song, Shunyi Lu, Zanjing Zhai, Jun Ge, Huiwu Li, Liang Cheng

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202409707

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Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes

Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a

Journal: Analytica Chimica Acta

Doi: 10.1016/j.aca.2024.342932

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CLASP-mediated competitive binding in protein condensates directs microtubule growth

Authors: Xuanyan Jia , Leishu Lin, Siqi Guo , Lulu Zhou , Gaowei Jin , Jiayuan Dong , Jinman Xiao , Xingqiao Xie , Yiming Li , Sicong He , Zhiyi Wei , Cong Yu

Journal: Nature Communications

PubMed ID: 39095354

Doi: 10.1038/s41467-024-50863-3

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Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Authors: Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39115358

Doi: 10.1002/anie.202411840

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A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Authors: Xuanxiu Ren # 1, Jiawen Sun # 2 3, Wenhua Kuang # 2, Feiyang Yu 1, Bingjie Wang 1, Yong Wang 2 3, Wei Deng 2 3, Zhao Xu 2 3, Shangyu Yang 1, Hualin Wang 2 4, Yangbo Hu 2 4, Zengqin Deng 5 6, Yun-Jia Ning 7 8, Haiyan Zhao

Journal: Nature Communications

PubMed ID: 39147753

Doi: 10.1038/s41467-024-51108-z

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Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

Authors: Shiman Zuo , Yuxin Wang , Hanjing Bao , Zehui Zhang , Nanfei Yang , Meng Jia , Qing Zhang , Ani Jian , Rong Ji , Lidan Zhang , Yan Lu , Yahong Huang , Pingping Shen

Journal: Nature Communications

PubMed ID: 39179603

Doi: doi.org/10.1038/s41467-024-51736-5

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Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy

Authors: Qian Qiu , Jiexin Li , He Ren , Jingyu Zhang , Gengqi Liu , Ruiqi Yang , Boyang Sun , Chen Zhang , Yumiao Zhang

Journal: Small

PubMed ID: 39114869

Doi: 10.1002/smll.202402308

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Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Authors: Sateesh Maddirevula , Mohammad Shagrani , Ae-Ri Ji , Christopher R Horne , Samuel N Young , Lucy J Mather , Mashael Alqahtani , Colin McKerlie , Geoffrey Wood , Paul K Potter , Firdous Abdulwahab , Tarfa AlSheddi , Wendy L van der Woerd , Koen L I van Gassen , Dalal AlBogami , Kishwer Kumar , Ali Syed Muhammad Akhtar , Hiba Binomar , Fowzan S Alkuraya

Journal: GENETICS IN MEDICINE

PubMed ID: 39132680

Doi: 10.1016/j.gim.2024.101231

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Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors

Authors: Shuai Chen , Kaixin Li , Xin Chen , Shan Lei , Jing Lin , Peng Huang

Journal: Science Advances

PubMed ID: 39213344

Doi: 10.1126/sciadv.adn8274

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Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions

Authors: Jiexin Li , Ruiqi Yang , Fuqiang Dong , Qian Qiu , Zhen Jiang , He Ren , Chen Zhang , Gengqi Liu , Jonathan F Lovell , Yumiao Zhang

Journal: ACS Nano

PubMed ID: 39109520

Doi: 10.1021/acsnano.3c12375

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A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Authors: Dimuthu Angage, Jill Chmielewski, Janesha C Maddumage, Eva Hesping, Sabrina Caiazzo, Keng Heng Lai, Lee Ming Yeoh, Joseph Menassa, D Herbert Opi, Callum Cairns, Hamsa Puthalakath, James G Beeson, Marc Kvansakul, Justin A Boddey, Danny W Wilson, Robin F Anders, Michael Foley

Journal: Nat Commun

PubMed ID: 39174515

Doi: 10.1038/s41467-024-50770-7

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Confined Gel-Electromembrane Extraction of Oligonucleotides

Authors: Cong Liu, Jie Liu, Quan Liu, Qianyun Zhu, Hao Wang, Xiangming Fang, Wenfang Zhang, Zilong Liu, Chuixiu Huang

Journal: ANALYTICAL CHEMISTRY

PubMed ID: 39078883

Doi: 10.1021/acs.analchem.4c02239

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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

Authors: Hongwei Zhang , Zhanxi Gu , Yuan Zeng , Yu Zhang

Journal: Structure

PubMed ID: 38870940

Doi: 10.1016/j.str.2024.05.013

Products & Services: Proteins, Expression, Isolation and Analysis

OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation

Authors: Xiao-Yu Teng , Ping Hu , Cai-Ming Zhang , Qin-Xin Zhang , Guolin Yang , Yan-Yu Zang , Zhi-Xiong Liu , Guiquan Chen , Yun Stone Shi

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39083419

Doi: 10.1073/pnas.2403652121

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A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

Authors: Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen

Journal: ADVANCED MATERIALS

PubMed ID: 39210649

Doi: 10.1002/adma.202410715

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Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma

Authors: Hong Han , Zenghui Li , Yuqing Feng , He Song , Zhixiong Fang , Dingxiao Zhang , Dan Yuan , Junfeng Shi

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39136347

Doi: doi.org/10.1002/anie.202407381

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The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery

Authors: Zhuang Zhang , Siying Li , Hongda Wang , Yuping Shan

Journal: Analytical Chemistry

PubMed ID: 39096242

Doi: 10.1021/acs.analchem.4c02270

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Reversible control of kinase signaling through chemical-induced dephosphorylation

Authors: Ying Sun , Rihong Zhou , Jin Hu , Shan Feng , Qi Hu

Journal: Communications Biology

PubMed ID: 39217250

Doi: 10.1038/s42003-024-06771-9

Products & Services: Proteins, Expression, Isolation and Analysis Recombinant Proteins

Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent

Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu

Journal: Bioactive Materials

Doi: doi.org/10.1016/j.bioactmat.2024.07.028

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Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein

Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery

Journal: Protein Sci

PubMed ID: 38864725

Doi: 10.1002/pro.5038

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The strongest protein binder is surprisingly labile

Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez

Journal: Protein Sci

PubMed ID: 38864696

Doi: 10.1002/pro.5030

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Fluorinated Titanium Oxide (TiO2-xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

Authors: Shumin Sun , Xuan Huang , Nailin Yang , Huali Lei , Zifan Pei , Zhihui Han , Lin Liu , Fei Gong , Qiao Yu , Jingrui Li , Youdong Chen , Liang Cheng

Journal: ACS Nano

PubMed ID: 39010657

Doi: 10.1021/acsnano.4c05448

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Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Authors: Michael J Peluso, Dylan Ryder, Robert R Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare, Maya Aslam, Walter Koch, Gyula Szabo, Rebecca Hoh, Monika Deswal, Antonio E Rodriguez, Melissa Buitrago, Viva Tai, Uttam Shrestha, Scott Lu, Sarah A Goldberg, Thomas Dalhuisen, Joshua J Vasquez, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Nitasha Kumar, Jeffrey N Martin, Aruna Gambhir, Ma Somsouk, Youngho Seo, Steven G Deeks, Zoltan G Laszik, Henry F VanBrocklin, Timothy J Henrich

Journal: Sci Transl Med

PubMed ID: 38959327

Doi: 10.1126/scitranslmed.adk3295

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Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Authors: Everardo R Rodriguez Rodriguez, Rune Thorbjørn Nordvang, Marcus Petersson, Jakob Kræmmer Haar Rendsvig, Emma Wenzel Arendrup, Monica L Fernández Quintero, Timothy P Jenkins, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Protein Sci

PubMed ID: 38923049

Doi: 10.1002/pro.5035

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering psychrophilic polymerase for nanopore long-read sequencing

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Bioeng Biotechnol

PubMed ID: 39011153

Doi: 10.3389/fbioe.2024.1406722

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Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ

Authors: Souradeep Banerjee, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar

Journal: Protein Sci

PubMed ID: 38864739

Doi: 10.1002/pro.5068

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Improvement and application of vacuum-infiltration system in tomato

Authors: Xinghao Yao, Ayat Taheri, Hang Liu, Yaojie Zhang, Ling Li, Jin Shao, Ke Wu, Qing Miao, Weizhi He, Xinyi Hu, Kexuan Tang

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhae197

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Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system

Authors: Danping Zhang 1, Liyang Du 1, Haishan Gao 2 3, Cai Yuan 4, Zhonghui Lin 1

Journal: Nucleic Acids Res

PubMed ID: 38967023

Doi: 10.1093/nar/gkae569

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The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis

Authors: Lei Shi, Changjiang Li, Gaofeng Lv, Xing Li, Wutao Feng, Yujing Bi, Wenhui Wang, Youqun Wang, Lei Zhu, Wenqiang Tang, Ying Fu

Journal: Plant Cell

PubMed ID: 38526222

Doi: 10.1093/plcell/koae086

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Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax

Authors: Yi Cao 1, Clifford T H Hayashi , Maisa da Silva Araujo , Abhai K Tripathi , Alice Oliveira Andrade , Jansen Fernandes Medeiros , Joseph Vinetz & Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39033079

Doi: 10.1016/j.vaccine.2024.07.041

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Cytochrome b5 diversity in green lineages preceded the evolution of syringyl lignin biosynthesis

Authors: Xianhai Zhao, Yunjun Zhao, Qing-Yin Zeng, Chang-Jun Liu

Journal: Plant Cell

PubMed ID: 38657101

Doi: 10.1093/plcell/koae120

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Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale

Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin

Journal: Cell

PubMed ID: 38936359

Doi: 10.1016/j.cell.2024.05.056

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Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer

Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri

Journal: Mol Cancer Ther

PubMed ID: 38638035

Doi: 10.1158/1535-7163.MCT-23-0766

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Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue

Journal: biorxiv

Doi: 2024.07.26.605286

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Impact of Equilibrative Nucleoside Transporters TgAT1, TgENT1, and TgENT3 on Toxoplasma gondii Infection and Differentiation

Authors: Amber Goerner, Gabriel Messina, Lea Drogalis Beckham, Bruno Martorelli Di Genova

Journal: biorxiv

Doi: doi.org/10.1101/2024.07.10.601519

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Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum

Authors: Zhengjie Wang, Ruili Lv, Chenglin Su, Yan Li, Sizhe Fang, Ruirui Yang, Jiaxuan Zhu, Ruiming Wang, Jun Meng, Yushi Luan

Journal: J Agric Food Chem

PubMed ID: 38994823

Doi: 10.1021/acs.jafc.4c03588

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Comparative biochemistry of PET hydrolase-carbohydrate-binding module fusion enzymes on a variety of PET substrates

Authors: Andrew Philip Rennison , Andreas Prestel , Peter Westh , Marie Sofie Møller

Journal: Enzyme and Microbial Technology

PubMed ID: 39047349

Doi: 10.1016/j.enzmictec.2024.110479

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Mechanism of ceramide synthase inhibition by fumonisin B1

Authors: Zike Zhang 1 2 4, Qi Fang 1 2 4, Tian Xie 1 2, Xin Gong

Journal: Structure

Doi: 10.1016/j.str.2024.06.002

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

Authors: Moisés Alejandro Alejo Hernandez , Katia Pamela Villavicencio Sánchez , Rosendo Sánchez Morales , Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez , Eddie Guillermo Sanchez-Rueda , Yanet Teresa-Cruz , Brian Choi, Armando Hernández Garcia , Alba Romero-Rodríguez, Oscar Juárez , Siseth Martínez-Caballero , Mario Figueroa , Corina-Diana Ceapă

Journal: Beilstein Journal of Organic Chemistry

PubMed ID: 39109298

Doi: 10.3762/bjoc.20.159

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Acceptors stability modulates the efficiency of post-translational protein N-glycosylation

Authors: Paula M Couto, Carlos M A Guardia, Facundo L Couto, Carlos A Labriola, María S Labanda, Julio J Caramelo

Journal: FASEB J

PubMed ID: 38934375

Doi: 10.1096/fj.202302267R

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Integration of validated functional evidence to support the pathogenicity of KCNH2 variants

Authors: Reema W Aljassar, Qianyi Shen, Buthaina Albash, Jamie I Vandenberg, Mohammad A Ebrahim, Chai-Ann Ng

Journal: Genet Med Open

PubMed ID: 39669639

Doi: 10.1016/j.gimo.2024.101868

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Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner

Authors: Lin-Chao Yu, Rui He, Dao-Xin Wang, Di Qi

Journal: Am J Respir Cell Mol Biol

PubMed ID: 38574235

Doi: 10.1165/rcmb.2024-0017OC

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METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA

Authors: Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu

Journal: Hereditas

PubMed ID: 38956710

Doi: 10.1186/s41065-024-00317-z

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Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Authors: Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn

Journal: J Mol Cell Biol

PubMed ID: 38253401

Doi: 10.1093/jmcb/mjae003

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Screening L-Lysine-Overproducing Escherichia coli Using Artificial Rare Codons and a Rare Codon-Rich Marker

Authors: Shen Li , Tianhao Xu , Xinru Meng , Yujuan Yan , Ying Zhou , Lei Duan , Yulong Tang , Li Zhu & Litao Sun

Journal: Nucleic Acids Research

PubMed ID: 38989624

Doi: doi.org/10.3390/

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DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants

Authors: Bingbing Yu , Yifan Chen , Yan Yan , Xueling Lu , Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38979568

Doi: 10.1093/nar/gkae593

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Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Authors: Yan Wang , Jing Zhang , Ying Liu , Xiao Yue , Kun Han , Zhichao Kong , Yuanmin Dong , Zhenmei Yang , Zhipeng Fu , Chunwei Tang , Chongdeng Shi , Xiaotian Zhao , Maosen Han , Zhibin Wang , Yulin Zhang , Chen Chen , Anning Li , Peng Sun , Danqing Zhu , Kun Zhao , Xinyi Jiang

Journal: Sci Adv

PubMed ID: 38865465

Doi: 10.1126/sciadv.ado4791

Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices

Authors: Yuxiang Liu, Ruixuan Wang, Qimingxing Chen, Yan Chang, Qi Chen, Kodai Fukumoto, Bingxun Wang, Jianchen Yu, Changfeng Luo, Jiayuan Ma, Xiaoxia Chen, Yuko Murayama, Kenichi Umeda, Noriyuki Kodera, Yoshie Harada, Shun-Ichi Sekine, Jianfeng Li, Hisashi Tadakuma

Journal: NANO LETTERS

PubMed ID: 38920331

Doi: 10.1021/acs.nanolett.4c02104

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A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7

Authors: Christian J Muñoz Sosa , Christopher Lenz , Anton Hamann , Frederic Farges , Johannes Dopfer , Andreas Krämer , Veronika Cherkashyna , Andrey Tarnovskiy , Yurii S Moroz , Ewgenij Proschak , Václav Němec , Susanne Müller , Krishna Saxena , Stefan Knapp

Journal: ACS Chem Biol

PubMed ID: 38934237

Doi: 10.1021/acschembio.4c00301

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Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals

Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang

Journal: Small Methods

PubMed ID: 38864527

Doi: 10.1002/smtd.202400664

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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

Authors: Huasong Ai , Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol

PubMed ID: 38918638

Doi: doi.org/10.1038/s41594-024-01342-2

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The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart

Authors: Elena Tsisanova, Muriel Nobles, Sonia Sebastian, Keat-Eng Ng, Alison Thomas, Lee Scott Weinstein, Patricia B Munroe, Andrew Tinker

Journal: J Biol Chem

PubMed ID: 38879012

Doi: 10.1016/j.jbc.2024.107470

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Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins

Authors: Piotr Kolesiński, Matthew McGowan, Anne Botteaux, Pierre R Smeesters, Partho Ghosh

Journal: J Biol Chem

PubMed ID: 38879009

Doi: 10.1016/j.jbc.2024.107478

Products & Services: Proteins, Expression, Isolation and Analysis

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