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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons

Authors: Shuai Jin, Zixu Zhu, Yunjia Li, Shouyue Zhang, Yijing Liu, Danyuan Li, Yuanqing Li, Yingfeng Luo, Zhiheng Cheng, Kevin Tianmeng Zhao, Qiang Gao, Guanglei Yang, Hongchao Li, Ronghong Liang, Rui Zhang, Jin-Long Qiu, Yong E Zhang, Jun-Jie Gogo Liu, Caixia Gao

Journal: Cell

PubMed ID: 41027434

Doi: doi.org/10.1016/j.cell.2025.09.004

Products & Services: Codon Optimization PCR Cloning and Subcloning

Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability

Authors: Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu, Jinyu Li, Baoli Yin, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song

Journal: Nature Communications

PubMed ID: 41173886

Doi: 10.1038/s41467-025-64633-2

Products & Services: Catalog Peptides

TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors

Authors: Min Duan, Pan Gao, Yi-Zhou Zhang, Yu-Long Hu, Lei Zhou, Zhong-Chen Xu, Hou-Yuan Qiu, Xiao-Han Tong, Rui-Jin Ji, Xin-Lin Lei, Hao Yin, Cun-Lan Guo, Ying Zhang

Journal: Nature Chemical Biology

PubMed ID: 40175512

Doi: 10.1038/s41589-025-01867-7

Products & Services: Synthetic Guide RNA

A dirigent protein redirects extracellular terpenoid metabolism for defense against biotic challenges

Authors: Jia-Ling Lin, Wen-Kai Wu, Gui-Bin Nie, Jian-Xu Li, Xin Fang, Yin-Guo Sheng, Meng-Meng Wang, Qi-Yue Zheng, Xiao-Xiang Guo, Jia-Fa Huang, Li-Ying Ma, Ling-Jian Wang, Jia-Xin Liu, Shan-Shan Wang, Baofu Xu, Yiqun Gao, Yan Li, Dong Wang, Cathie Martin, Xiao-Ya Chen & Jin-Quan Huang

Journal: Nature Communications

PubMed ID: 41115945

Doi: 10.1038/s41467-025-64323-z

Products & Services: Protein Electrophoresis and Western

A motif preferred adenine base editor with minimal bystander and off-targets editing

Authors: Mengyu Shang, Yinuo Li, Qiuyu Cao, Jingxuan Ren, Yuqiang Zeng, Jinxin Wang, Rachel V. L. Gonzalez & Xiaohui Zhang

Journal: Nature Communications

PubMed ID: 41093849

Doi: 10.1038/s41467-025-64203-6

Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1

Authors: Behnaz Davoudinasab, Aleksey Raskovalov, Woojin Lee, Donggyun Kim, Heesoo Kim, Jordy Homing Lam, Gye Won Han, Vsevolod Katritch, Vadim Cherezov

Journal: Nature Communications

PubMed ID: 41062467

Doi: 10.1038/s41467-025-64002-z

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

Authors: Giovanni Luchetti, Marin V. Miner, Rachael M. Peterson, William P. Scott, Praveen Krishnamoorthy, Eric M. Kofoed, Angel G. Jimenez, Hua Zhang, Man Wah Tan, Rohit Reja, Tommy K. Cheung, Elizabeth Skippington, Yuxin Liang, Christopher M. Rose, Nobuhiko Kayagaki, Kim Newton, Isabella Rauch & Vishva M. Dixit

Journal: Nature

PubMed ID: 41125892

Doi: 10.1038/s41586-025-09645-0

Signal-strapping as a protein-sequence search method for the discovery of metalloproteins

Authors: João Paulo L Franco Cairo, Thamy L R Corrêa, Wendy A Offen, Alison K Nairn, Julia Walton, Sean T Sweeney, Gideon J Davies, Paul H Walton

Journal: Nature Communications

PubMed ID: 41115942

Doi: 10.1038/s41467-025-64309-x

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against nonsmall cell lung cancer

Authors: Jia-Hao Tao, Jun Zhang, Chun-Yan Tang, Jia-Xi Duan, Wen-Jing Zhong, Chen-Yu Zhang, Yu-Biao Liu, Jin Ling, Hua-Shun Li, Yong Zhou, Cha-Xiang Guan

Journal: Cancer gene therapy

PubMed ID: 40913086

Doi: 10.1038/s41417-025-00957-x

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases

Authors: Qiang Gao, Yunxia Gao, Yingui Cao, Haiting Xu, Ya Ma, Menghang Zu, Qiang Yang, Kun Yang, Zhenhua Zhu, Chao Liu, Xiaoxiao Shi, Rui L Reis, Subhas C Kundu, Shengyun Ma, Hesong Han, Bo Xiao

Journal: SCIENCE ADVANCES

PubMed ID: 41004579

Doi: 10.1126/sciadv.adw9275

Products & Services: Catalog Gene Editing

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Authors: Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, Qingqing Chu, Jing Zhang, Yifan Wen, Yaobin Jing, Shuhui Sun, Qin Qiao, Qian Zhao, Qianzhao Ji, Shuai Ma, Yusheng Cai, Yandong Zheng, Zhiran Zou, Zhiqing Diao, Mingheng Li, Hao Zhang, Jianli Hu, Liangzheng Fu, Wang Kang, Ruijun Bai, Hongkai Zhao, Sheng Zhang, Yingjie Ding, Jinghui Lei, Wei Wang, Yun Ji, Bo Gou, Guoqiang Sun, Jian Yin, Pengze Yan, Hao Li, Zehua Wang, Shikun Ma, Zunpeng Liu, Hezhen Shan, Qiaoran Wang, Tianling Cao, Shanshan Yang, Cui Wang, Ping Yang, Yanling Fan, Yanxia Ye, Jinghao Hu, Mengmeng Jiang, Ye Wang, Kan Liu, Yujing Li, Yuanxiang Li, Jingyi Li, Weimin Ci, Zi-Bing Jin, Xiaobing Fu, Xu Zhang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Journal: Cell

PubMed ID: 40570836

Doi: 10.1016/j.cell.2025.06.001

Products & Services: Synthetic Guide RNA

RING-Between-RING-Type E3 Ligase Ariadne-Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein

Authors: Wenli Li, Chenchen Zhong, Jiangning Duan, Changyi Zhan, Zhaolei Li, Xinyu Zhang, Dingliang Zhang, Deshui Liu, Zhiyan Wen, Xiaofei Zhao, Meng Yang, Dawei Li, Yongliang Zhang

Journal: Advanced Science

PubMed ID: 40908568

Doi: 10.1002/advs.202509942

Protein M fusion proteins and uses

Authors: Jay Dela Cruz , Moreno Valley , CA

Journal: U.S. Patent

Doi: US11401309B2

Products & Services: Gene Synthesis Plasmid DNA Preparation Catalog Antibodies Codon Optimization

Multilevel regulation of c-di-GMP biosynthesis by cAMPsignalingincreasesShigellasonneifitnessand pathogenicity in response to bile salts

Authors: Mingfang Wang, Jia Zeng, Binbin Cui, Guangliang Wu, Xiayu Chen, Yikai Fu, Bing Gu, Yinyue Deng

Journal: Cell Rep

PubMed ID: 40966079

Doi: 10.1016/j.celrep.2025.116306

Products & Services: Protein Electrophoresis and Western

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Authors: Man Wang, Ziyu Zhang, Xiaohan Wang, Liyan Zhang, Xiangyan Chen, Nianci Li, Qiuhan Sun, Yicheng Lu, Zuhong He, Hongbo Yang, Fangzhi Tan, Jieyu Qi, Renjie Chai

Journal: Nature Communications

PubMed ID: 40968144

Doi: 10.1038/s41467-025-63613-w.

Products & Services: Protein and Antibody Isolation

Multifunctional NAC transcription factor SlJA2L integrates the ethylene pathway to orchestrate thermotolerance and fruit ripening in tomato

Authors: Yunfei Liang, Fang Ma, Shudi Huang, Chao Ma, Hongyan Shi, Fanyi Meng, Yinglu Chen, Han Dong, Rugang Chen, Xiangqiang Zhan

Journal: New Phytologist

PubMed ID: 40963426

Doi: 10.1111/nph.70571

Products & Services: Catalog Antibodies

OsEHD1 and OsEHD2, two EH domain proteins targeted by E3 ubiquitin ligase OsBBI1, negatively modulate rice immunity against blast and bacterial blight diseases

Authors: Yan Bi, Yuqing Yan, Hui Wang, Leeza Tariq, Jiamu Wang, Dayong Li, Yayun Yang, Fengming Song

Journal: Crop Journal

Doi: doi.org/10.1016/j.cj.2025.09.003

Products & Services: Catalog Antibodies

SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPAR

Authors: Shuai Wang, Ting He, Tong Fu, Yu Zhu, Yixin Wei, Wenlong Xie, Huanming Shen, Ya Luo, Boan Li, Huiling Guo, Weihua Li

Journal: Advanced Biology

PubMed ID: 40977422

Doi: 10.1002/adbi.202500224

Products & Services: Catalog Antibodies

The EP300-Targeting Drug CCS1477 Inhibits the Growth and Development of Diffuse Large B-Cell Lymphoma by Promoting Apoptosis and Mitophagy to Reduce Drug Resistance

Authors: Rujia Si, Yihan Zhang, Bowen Hu, Yuxin Du, Dan Zou, Shaodi Wen, Xiaoyue Du, Xin Chen, Chen Peng, Shulei Fu, Shiying Zhu, Fan Du, Xiaofeng Sha, Ning Ding, Cong Xu, Bo Shen

Journal: Anti-Cancer Agents in Medicinal Chemistry

Doi: 10.2174/0118715206430859250915050817

Products & Services: Protein Electrophoresis and Western

Provision of a Redox Donor to Oxy-Ferrous PrnB Is Required for Pyrrolnitrin Synthesis

Authors: R Brian McMillan, Hannah E Gering, Anastasia E Ledinina, Shan Xue, Sayali Karandikar, Shuangjun Lin, Garim You, Tzu-Yu Chen, Yisong Guo, Wei-Chen Chang, Thomas M Makris

Journal: Biochemistry

PubMed ID: 40827054

Doi: 10.1021/acs.biochem.5c00263

Products & Services: Gene Synthesis PCR Cloning and Subcloning Codon Optimization

M2e peptide libraries were synthesized on the basis of the M2e-CS peptide, N-SLLTEVETPIRNEWGCRCNDSSD, and purchased from GenScript.

Authors: Teha Kim, Lynn Bimler, Sydney L Ronzulli, Amber Y Song, Scott K Johnson, Cheryl A Jones, S Mark Tompkins, Silke Paust

Journal: SCIENCE ADVANCES

PubMed ID: 40929256

Doi: 10.1126/sciadv.adx3505

Products & Services: Peptide Services

Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines

Authors: Samuel J Vidal, Ninaad Lasrado, Lisa H Tostanoski, Jayeshbhai Chaudhari, Esther R Mbiwan, Ganad D Neka, Ellis A Strutton, Alejandro A Espinosa Perez, Daniel Sellers, Julia Barrett, Michelle Lifton, Shoko Wakabayashi, Behnaz Eshaghi, Erica N Borducchi, Malika Aid, Wenjun Li, Thomas J Scriba, Ana Jaklenec, Robert Langer, Dan H Barouch

Journal: Cell

PubMed ID: 40957415

Doi: 10.1016/j.cell.2025.08.027

Products & Services: Peptide Services

Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activation

Authors: Kamalakshi Deka, Jean-Michel Carter, Akash Bahai, Daniel Aron Ang, Nicholas Sim, Hooi Yan Chong, Guan Hwee Bernard Lee, Suet Mien Tan, Wee Joo Chng, Dennis Kappei, Yinghui Li

Journal: Nature Communications

PubMed ID: 40890111

Doi: 10.1038/s41467-025-63256-x.

Products & Services: Gene Services

The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses

Authors: Kira Schamoni-Kast, Boris Krichel, Tomislav Damjanović, Fatema-Aqila Said, Thomas Kierspel, Sibel Toker, Charlotte Uetrecht

Journal: Nature Communications

PubMed ID: 40925907

Doi: 10.1038/s41467-025-61554-y.

Products & Services: Gene Services

Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors

Authors: Rupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, Simone Marzaro, Mario Schubert, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O Dahms

Journal: Nature Communications

PubMed ID: 40897699

Doi: 10.1038/s41467-025-63479-y.

Ultrastrong Staphylococcus aureus adhesion to human skin: Calcium as a key regulator of noncovalent interactions

Authors: Constance Chantraine, Priscila S F C Gomes, Marion Mathelié-Guinlet, Diego E B Gomes, Zhiyong Zheng, Julianne Clowry, Mary B Turley, Alan D Irvine, Joan A Geoghegan, Rafael C Bernardi, Yves F Dufrêne

Journal: SCIENCE ADVANCES

PubMed ID: 40901964

Doi: 10.1126/sciadv.adu7457

Molecular exaptation by the integrin αI domain

Authors: Jeremy A Hollis, Matthew C Chan, Harmit S Malik, Melody G Campbell

Journal: SCIENCE ADVANCES

PubMed ID: 40929264

Doi: 10.1126/sciadv.adx9567

Products & Services: Gene Services

UHRF1 Controls the Timing of RAD51 Removal During DNA Damage Repair Through Suppressing RFWD3

Authors: Guangxue Liu, Kaiyan Huang, Shiyao Liu, Ziyu Sheng, Pumin Zhang

Journal: Advanced Science

PubMed ID: 40940676

Doi: 10.1002/advs.202509901

SLC25A39 overexpression exacerbates lung adenocarcinoma progression and is negatively regulated by AFG3L2

Authors: Wenxuan Hu, Jian Yang, Zhike Chen, Yongsen Li, Gaomeng Luo, Kang Hu, Zihao Lu, Xin Lv, Yonghao Cao, Haoyang Yuan, Cong Cao, Jun Zhao, Chun Xu

Journal: NPJ precision oncology

PubMed ID: 40993178

Doi: 10.1038/s41698-025-01081-7

Products & Services: Protein and Antibody Isolation

Peptide codes for organ-selective mRNA delivery

Authors: Tie Chang, Yifan Zheng, Mingrui Jiang, Siqi Jia, Jianbo Bai, Zhi Zheng, Shixin Li, Jia Guo, Yue Wang, Yiting Wang, Haixia Liu, Jianlin Liu, Liangyu Ni, Xingdi Cheng, Shuai Liu, Huijuan Zhang, Wei Pi, Feng Lin, Shiyi Liu, Weijian Wang, Guannan Wang, Leyun Wang, Lei Miao, Xueguang Lu, Ziqing Deng, Bing Bai, Zhao Qin, Huajian Gao, Yue Shao

Journal: Nature materials

PubMed ID: 40890497

Doi: 10.1038/s41563-025-02331-6

Products & Services: Catalog Gene Editing

Machine learning-based analysis of the impact of 5′ untranslated region on protein expression

Authors: Linfeng Wang, Sujia Liu, Jia-Xin Huang, Haifeng Zhu, Shuyu Li, Yannan Li, Sen Chen, Jianying Han, Yin Zhu, Jiahao Wu, Wentao Liao, Hongmei Zhang, Haiyan Zeng, Shaoting Li, Shuping Zhao, Bingwei Wang, Jiaqi Lin, Ji Zeng

Journal: Nucleic Acids Research

PubMed ID: 40923765

Doi: 10.1093/nar/gkaf861

Products & Services: Gene Synthesis

OsSTK-mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defense in Rice

Authors: Jitao Hu, Linying Li, Yao Zhao, Xueying Zhang, Hua Wang, Junmin Wang, Peng Sun, Li Jiang, Jingqi Wang, Lili Chen, Zhongjing Zhou, Jiaoyu Wang, Keke Yi, Yuqing He, Gaojie Hong

Journal: Plant Biotechnology Journal

PubMed ID: 40927945

Doi: 10.1111/pbi.70358

Products & Services: Catalog Antibodies

Amplifying antigen-induced cellular responses with proximity labelling

Authors: Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao, Shuo Han

Journal: Nature

PubMed ID: 40931066

Doi: 10.1038/s41586-025-09518-6. Online ahead of print.

Products & Services: Peptide Synthesis

Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles

Authors: An Lao, Weiqi Li, Yiting Sun, Yuting Cao, Yu Zhuang, Jianyong Wu, Dejian Li, Kaili Lin, Jing Mao, Jiaqiang Liu

Journal: Trends in biotechnology

PubMed ID: 40925799

Doi: 10.1016/j.tibtech.2025.07.025

Products & Services: Protein and Antibody Isolation

A reproducible hybrid membrane for in situ analysis of cell secretions with a wide size range

Authors: Zixuan Chen, Yafeng Wu, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.110917

Products & Services: Recombinant Proteins

De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Authors: Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Tao Qian, Bang-Ce Ye, Bin-Cheng Yin

Journal: Nat Commun

PubMed ID: 41006213

Doi: 10.1038/s41467-025-63166-y

Products & Services: Gene Synthesis

Microgel Aspect Ratio Influences Injectable Granular Hydrogel Scaffold Pore Structure and Cellular Invasion for Tissue Repair

Authors: Gabriel J Rodriguez-Rivera, Siddharth Sharma, Chima V Maduka, Sara Boyd, Amy R Perry, Nikolas Di Caprio, Lindsay Riley, Connor E Miksch, Daeyeon Lee, Tatiana Segura, David Issadore, Jason A Burdick

Journal: Advanced Science

PubMed ID: 40940307

Doi: 10.1002/advs.202511513

Products & Services: Peptide Services

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Authors: Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang

Journal: Advanced Science

PubMed ID: 40940305

Doi: 10.1002/advs.202503534

Products & Services: Gene Services

Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants

Authors: Maxwell R Fishman, Anne Greifenhagen, Takanori Wakatake, Anuphon Laohavisit, Ryoko Hiroyama, Sachiko Masuda, Arisa Shibata, Satoko Yoshida, Ken Shirasu

Journal: SCIENCE ADVANCES

PubMed ID: 40961186

Doi: 10.1126/sciadv.adw3965

Products & Services: Gene Services

Intrinsically disordered region of Clr4/Suv39 regulates its enzymatic activity and ensures heterochromatin spreading

Authors: Rinko Nakamura, Aki Hayashi, Reiko Nakagawa, Yuriko Yoshimura, Naoki Horikoshi, Hitoshi Kurumizaka, Jun-Ichi Nakayama

Journal: Nucleic Acids Research

PubMed ID: 40923761

Doi: 10.1093/nar/gkaf878

Computational design of potent and selective binders of BAK and BAX

Authors: Stephanie Berger, Erinna F Lee, Tiffany J Harris, Sharon Tran, Asim K Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S Miller, Sean Smyth, Mariam Lutfi, Rachel T Uren, Ruth M Kluck, Peter M Colman, Walter D Fairlie, Peter E Czabotar, David Baker, Richard W Birkinshaw

Journal: SCIENCE ADVANCES

PubMed ID: 40911686

Doi: 10.1126/sciadv.adt4170

Planthopper protein Nlsp5 is essential for salivary sheath formation and acts as a HAMP inducing plant resistance to insects

Authors: Liangxuan Qi, Jing Li, Han Wang, Shuai Li, Lei Yang, Jichao Fang, Rui Ji

Journal: Plant Biotechnology Journal

PubMed ID: 40546084

Doi: DOI10.1111/pbi.70223

Products & Services: Polyclonal Antibody Services

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects Against In Vivo Infection via the Induction of Broad-Spectrum PRRSV Neutralization

Authors: Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A Hiscox, James P Stewart, Yani Sun, Qin Zhao

Journal: Advanced Science

PubMed ID: 40919718

Doi: 10.1002/advs.202508875

Products & Services: Molecular Biology Reagents

Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing

Authors: Changwei Shao, Yajing Hao, Li Jiang, Dong Wang, Rui Wang, Yuanjun Li, Hui Wang, Yaping Ge, Rui Bai, Xiangjuan Du, Xizi Chen, Tan Wu, Lan-Tao Gou, Ruixue Wan, Yanhui Xu, Xiong Ji, Xiang-Dong Fu

Journal: Science

PubMed ID: 40997183

Doi: 10.1126/science.adj9141

Products & Services: Protein Electrophoresis and Western

OLD amputates the anticodon arm of tRNAs during P2–Lambda interference

Authors: Apurva A Govande, Brian D Matibag, Irem Ünlü, Eric J Wolf, Molly R Sargen, Brooke Ramsey, Sangjin Kim, Sophie Helaine, Ivan R Corrêa Jr, Hoong Chuin Lim

Journal: Nucleic Acids Research

PubMed ID: 40966496

Doi: 10.1093/nar/gkaf874

Products & Services: Gene Services

A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection

Authors: Yumeng Xiao, Junyu Chen, Xincan Hou, Hongwei Wang, Kundi Zhang, Sujuan Xu, Tao Jiang, Yangao Huo, Fengyu Zhang, Lichuan Gu

Journal: Nucleic Acids Research

PubMed ID: 40966498

Doi: 10.1093/nar/gkaf907

Products & Services: Gene Services

SMAD3 and p300 complex scaffolding by long non-coding RNA LIMD1-AS1 promotes TGF-β-induced breast cancer cell plasticity

Authors: Chuannan Fan， Davy Cats， Miriam Selle， Olga Khorosjutina， Soniya Dhanjal， Bernhard Schmierer， Hailiang Mei， Peter Ten Dijke， Qian Wang

Journal: Nucleic Acids Research

PubMed ID: 40889156

Doi: 10.1093/nar/gkaf841

Products & Services: CRISPR Services

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Authors: Edgar J. Soto-Moreno, Nourhan N. Ali, Florian Küllmer, Veselin Nasufovic, Michaela Frolikova, Olga Tepla, Jaromir Masata, Dirk Trauner, Amanda A. Patterson, Hans-Dieter Arndt, Katerina Komrskova, Magdalena Zernicka-Goetz, David M. Glover & Ahmed Z. Balboula

Journal: Nature Communications

PubMed ID: 40973727

Doi: 10.1038/s41467-025-63586-w

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α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

Authors: Canqi Cui, Danielle C Leander, Sarah M Gray, Kimberley El, Alex Chen, Paul A Grimsrud, Jessica O Becker, Austin Taylor, Guo-Fang Zhang, Kyle W Sloop, C Bruce Verchere, Andrew N Hoofnagle, David A D'Alessio, Jonathan E Campbell

Journal: SCIENCE ADVANCES

PubMed ID: 40971442

Doi: 10.1126/sciadv.ady8048

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila

Authors: Chongyang Li, Zhe Meng, Qiuju Wen, Wenjuan Yang, Yaqian Xu, Yuening Lyu, Yile Guo, Tong Lyu, Dan Shen, Kun Dou

Journal: Nucleic Acids Research

PubMed ID: 40966519

Doi: 10.1093/nar/gkaf903

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

Authors: Bin Liu, Yansi Xian, Tao Shen, Yu Ben, Wenshu Wu, Yong Shi, Xueying An, Rui Peng, Wentian Gao, Wang Gong, Xiang Chen, Baosheng Guo, Qing Jiang

Journal: Journal of extracellular vesicles

PubMed ID: 40919882

Doi: 10.1002/jev2.70162

Products & Services: Protein and Antibody Isolation

PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

Authors: Shen Yang, Eugenio Santelli, Carlos G Gonzalez, Wade T Johnson, Irene V Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M Rossitto, I-Shing Yu, Shu-Wha Lin, Yuan Zhan, Qinwei Chen, Jonathan D Yoshihara, Daniel J Wallace, Caroline A Jefferies, Michifumi Yamashita, David J Gonzalez, Richard I Ainsworth, Nisarg J Shah, Stephanie M Stanford, Nunzio Bottini

Journal: SCIENCE ADVANCES

PubMed ID: 40911684

Doi: 10.1126/sciadv.adw2568

Products & Services: Gene Services

Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica

Authors: Byoung Seung Jeon, Eun-Jung Kim, Hogyun Seo, Hyunjin Kim, Seungjin Shin, Caroline Schlaiß, Largus T Angenent, Kyung-Jin Kim, Byoung-In Sang

Journal: Advanced Science

PubMed ID: 40932660

Doi: 10.1002/advs.202506069

The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat

Authors: Wen Yang, Renhan Li, Man Feng, Zhen Qin, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Wen Song, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: SCIENCE ADVANCES

PubMed ID: 40901958

Doi: 10.1126/sciadv.ady1949

Products & Services: Peptide Services

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Authors: Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo

Journal: Advanced Science

PubMed ID: 40948085

Doi: 10.1002/advs.202506367

Products & Services: Peptide Services

Controllable Generation of Pathogen-Specific Antimicrobial Peptides Through Knowledge-Aware Prompt Diffusion Model

Authors: Yongkang Wang, Menglu Li, Feng Huang, Minyao Qiu, Wen Zhang

Journal: Advanced Science

PubMed ID: 40953451

Doi: 10.1002/advs.202507457

Products & Services: Peptide Services

Covariation MS uncovers a protein that controls cysteine catabolism

Authors: Haopeng Xiao, Martha Ordonez, Emma C. Fink, Taylor A. Covington, Hilina B. Woldemichael, Junyi Chen, Mika Sarkin Jain, Milan H. Rohatgi, Shelley M. Wei, Nils Burger, Muneeb A. Sharif, Julius Jan, Yaoyu Wang, Jonathan J. Petrocelli, Katherine Blackmore, Amanda L. Smythers, Bingsen Zhang, Matthew Gilbert, Hakyung Cheong, Sumeet A. Khetarpal, Arianne Smith, Dina Bogoslavski, Yu Lei, Laura Pontano Vaites, …Edward T. Chouchani

Journal: https://www.nature.com/ Nature

PubMed ID: 40963025

Doi: 10.1038/s41586-025-09535-5

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

Journal: Nature Communications

PubMed ID: 40813592

Doi: doi.org/10.1038/s41467-025-63101-1

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Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases

Authors: Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Journal: Biomolecules

PubMed ID: 40867598

Doi: 10.3390/biom15081153

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Chimeric virus-like particles replacing the loop on the surface of VP60 from rabbit hemorrhagic disease virus (RHDV) provide protection against two serotypes of RHDV

Authors: Wangzhen Xiang, Beibei Pan, Yuxin Hao, Fei Wang, Jialu Bao, Shanchun Su, Shuai Qie, Chungang Pan, Zhen Cao, Xinyue Liu, Jiajun Wu, Tong Zhang, Xinyan Zhai, Fei Yang, Peng Qi, Jiangtao Wang, Jin Xiao, Xin Guo

Journal: Vaccine

PubMed ID: 40614613

Doi: 10.1016/j.vaccine.2025.127427

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Characterization and Engineering of Two Novel Strand-Displacing B Family DNA Polymerases from Bacillus Phage SRT01hs and BeachBum

Authors: Yaping Sun, Kang Fu, Wu Lin, Jie Gao, Xianhui Zhao, Yun He, Hui Tian

Journal: Biomolecules

PubMed ID: 40867571

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Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states

Authors: Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W Siebel, M Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao

Journal: Nature Communications

PubMed ID: 40753156

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Broad neuraminidase antibodies confer protection against seasonal and avian influenza viruses

Authors: Kexin Lv, Xiaoman Li, Xingchen Zhu, Jian-Piao Cai, Shuning Liu, Yuzhu Sun, Lin Liu, Xiaoyu Cai, Rui Cao, Mengxin Xu, Xinyu Yue, Yanmei Zhai, Wanyu Luo, Hongjie Lu, Ruiying Li, Haoting Mai, Lei Deng, Feng Ye, Shifeng Chen, Mang Shi, Huanle Luo, Xinquan Wang, Shuofeng Yuan, Yuelong Shu, Jiwan Ge, Yao-Qing Chen

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A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice

Authors: Yang Zhou, Yu Wei, Jianli Yin, Deqiang Kong, Wenjun Li, Xinyi Wang, Yining Yao, Qin Huang, Lei Li, Mengyao Liu, Longliang Qiao, Huiying Li, Junwei Zhao, Tao P Zhong, Dali Li, Liting Duan, Ningzi Guan, Haifeng Ye

Journal: Nucleic Acids Research

PubMed ID: 40795961

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METTL9 sustains vertebrate neural development primarily via non-catalytic functions

Authors: Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, Eleonora Crocco, Paolo Bianchini, Andrew J Bannister, Stefano Gustincich, Tony Kouzarides, Riccardo Rizzo, Isaia Barbieri, Federico Cremisi, Robert Vignali, Luca Pandolfini

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PubMed ID: 40745158

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Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems

Authors: Audrey Leprince, Justine Lefrançois, Anne M Millen, Damian Magill, Philippe Horvath, Dennis A Romero, Geneviève M Rousseau, Sylvain Moineau

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A streamlined CRISPR-based test for tuberculosis detection directly from sputum

Authors: Alexandra G Bell, Owen R S Dunkley, Nisha H Modi, Yujia Huang, Soleil Tseng, Robert Reiss, Naranjargal Daivaa, J Lucian Davis, Deninson Alejandro Vargas, Padmapriya Banada, Yingda L Xie, Cameron Myhrvold

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PubMed ID: 40768573

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Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function

Authors: Kumari Kavita, Aya Narunsky, Jessica J Mohsen, Isha Mahadeshwar, Michael G Mohsen, Yu-Shin Chang, Ronald R Breaker

Journal: Nature Communications

PubMed ID: 40783389

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eIF2A regulates cell migration in a translation-independent manner

Authors: Jennifer Jungfleisch, Neus Mestre-Farràs, Raúl Gómez-Riera, Oriane Pourcelot, Edouard Bertrand, Nadia Halidi, Fátima Gebauer

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PubMed ID: 40749049

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Dopamine signaling drives skin invasion by human-infective nematodes

Authors: Ruhi Patel, Gloria Bartolo, Michelle L Castelletto, Aracely Garcia Romero, Astra S Bryant, George W Agak, Elissa A Hallem

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HERV-K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

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4D structural biology-quantitative dynamics in the eukaryotic RNA exosome complex

Authors: Jobst Liebau, Daniela Lazzaretti, Torben Fürtges, Anna Bichler, Michael Pilsl, Till Rudack, Remco Sprangers

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Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis

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PubMed ID: 40854908

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Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization

Authors: Ming Zeng, Shuai Fu, Youping Xu, Liyan Li, Dan Wang, Shi-Bo Gao, Lianshun Zheng, Yunge Zhang, Cui Zhang, Shifang Fei, Xuan Ye, Lele Chen, Yaqin Wang, Tong Zhang, Xueping Zhou, Jianxiang Wu

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Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

Authors: Xin Zhou, Miesje M van der Stoel, Shreyas Kaptan, Haoran Li, Shiqian Li, Maarit Hölttä, Helena Vihinen, Eija Jokitalo, Christoph Thiele, Olli Pietiläinen, Shin Morioka, Junko Sasaki, Takehiko Sasaki, Ilpo Vattulainen, Elina Ikonen

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Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

Authors: Inês De Magalhaes Pinheiro, John R D Dawson, Nicolas Calo, Marianne Paolini-Bertrand, Kalyana Bharati Akondi, Gavin Tan, Tracy M Handel, Irina Kufareva, Oliver Hartley

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Digital light processing of photoresponsive and programmable hydrogels

Authors: Abhishek P Dhand, Bruce E Kirkpatrick, Manuela Garay-Sarmiento, Benjamin R Nelson, Connor E Miksch, Bianca Meurer-Zeman, Hannah M Zlotnick, Arkodip Mandal, Joshua S Lee, Jaxon Cione, Christopher N Bowman, Kristi S Anseth, Jason A Burdick

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PubMed ID: 40779636

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PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes

Authors: Emily C A Goodall, Freya Hodges, Weine Kok, Budi Permana, Thom Cuddihy, Zihao Yang, Nicole Kahler, Kenneth Shires, Karthik Pullela, Von Vergel L Torres, Jessica L Rooke, Antoine Delhaye, Jean-François Collet, Jack A Bryant, Brian M Forde, Matthew R Hemm, Ian R Henderson

Journal: Nucleic Acids Research

PubMed ID: 40808296

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Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes

Authors: Dhana G Gorasia, Eric Hanssen, Manasi Mudaliyar, Craig J Morton, Sepideh Valimehr, Christine Seers, Lianyi Zhang, Matthew T Doyle, Debnath Ghosal, Paul D Veith, Eric C Reynolds

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Vortex-Generated Microdroplets Enable Simple, Rapid, and Low-Volume Measurement of Condensate Volume and Concentration

Authors: Feipeng Chen, Ho Cheung Shum

Journal: Advanced Science

PubMed ID: 40841927

Doi: 10.1002/advs.202511197

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Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions

Authors: Jiayu Gu, Lihui Lao, Linzhen Hu, Jia Zang, Chao Liu, Ruixi Wan, Ling Tang, Ying Yuan, Yulin Chen, Shixian Lin

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Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

Authors: Dhanya Thamaraparambil Jayaram, Pranav Sivaram, Pranjal Biswas, Yue Dai, Elizabeth A Sweeny, Dennis J Stuehr

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Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education

Authors: Shilpi Agrawal, Abbey L Stokes, Christopher E Nelson

Journal: biorxiv

PubMed ID: 40766677

Doi: 10.1101/2025.07.31.667476

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Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma

Authors: Shi-Man Zhang, Xiao-Kang Jin, Hong Chen, Yu-Zhang Wang, Jun-Long Liang, Jun Feng, Wei-Hai Chen, Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 40757917

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Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress

Authors: Hui Guan, Liqi Huang, Yu Liu, Enyi Zhu, Lefeng Chen, Weijie Li, Haiqi Wu, Xiaoying Zhang, Rencai Qin, Jingpeng Zheng, Yingqian Mo, Ming Zhong, Bihua Xu, Xiaoyan Dai, Qi Wei, Yunwei Chen, Qingwen Wang, Zhihua Zheng, Kongyang Ma, Chun Tang

Journal: Journal of Inflammation Research

PubMed ID: 106070

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Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

Authors: Zeguang Wu, Jinhong Shi, Qiezhong Lamao, Yuanyuan Qiu, Jinxin Yang, Yang Liu, Feifei Liang, Xue Sun, Wei Tang, Changya Chen, Qingming Yang, Chunmeng Wang, Zhifang Li, Haixia Zhang, Zhonghan Yang, Yunyi Zhang, Yuting Yi, Xufen Zheng, Yu Sun, Kuiying Ma, Lingling Yu, Huihui Yang, Zhaoxuan Wang, Wenjuan Zheng, Ling Yang, Zhixuan Zhang, Yongjian Zhang, Zhiqiang Wu, Yao Wang, Catherine C L Wong, Ming Jin, Pengfei Yuan, Weidong Han, Wensheng Wei

Journal: Cell

PubMed ID: 40845838

Doi: doi.org/10.1016/j.cell.2025.07.046

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A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection

Authors: Yannan Yin, Jinkai Zang, Huichun Shi, Zhuang Wang, Linlin Kuang, Shuxia Wang, Haikun Wang, Ning Li, Xiaozhen Liang, Zhong Huang

Journal: Vaccines

PubMed ID: 40872916

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ANovelDeNovoBiosyntheticPathwayforEfficientSynthesisof6′ SialyllactoseinEscherichiacoli

Authors: Manxiang Zhu,Hongzhi Xia, Xianhao Xu, Yanfeng Liu, Guocheng Du,XuKueqin Lv, Long Liu, Shixiu Cui, Jianghua Li, and Yingyue Li

Journal: Synthetic Biology

Doi: 10.1021/acssynbio.5c00437

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Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM

Authors: Jeremy Shek; Chen Sun; Elise M. Wilson; Fatemeh Moadab; Kathryn M. Hastie; Roshan R. Rajamanickam; Patrick J. Penalosa; Stephanie S. Harkins; Diptiben Parekh; Chitra Hariharan; Dawid S. Zyla; Cassandra Yu; Kelly C. L. Shaffer; Victoria I. Lewis; Ruben Diaz Avalos; Tomas Mustelin; Erica Ollmann Saphire

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PubMed ID: 40864726

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Genetic architecture of a light-temperature coincidence detector

Authors: Adam Seluzicki , Joanne Chory

Journal: Nature Communications

PubMed ID: 40858539

Doi: 10.1038/s41467-025-62194-y.

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Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling

Authors: Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu

Journal: Advanced Science

PubMed ID: 40789101

Doi: 10.1002/advs.202509846

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Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI

Authors: Shengnan Li, Zhaoliang Shan, Guochun Zhao, Yuwei Li, Minghui Du, Xiuxiu Ti, Yuxue Gao, Wenting Li, Hui Zuo, Yan Wang, Qing Zhang

Journal: Nature Communications

PubMed ID: 40774949

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Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming

Authors: Shanhao Jin, Liqi Zhu, Ruoyu Bao, Linghan Yang, Tinglong Zhuang, Liyou Lian, Tao Wang, Jun Yin, Shilei Zhang, Lei Zhou, Minghua Zheng, Quan Zhang

Journal: Nature Communications

PubMed ID: 40858606

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Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy

Authors: Ying Wang, Jiayao Yan, Lin Li, Tianran Chen, Jingyi Guo, Lei Lei, Siwen Wu, Lijing Zhu, Xiaotong Chen, Baorui Liu

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PubMed ID: 40849430

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Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious

Authors: Jiří Holoubek, Jiří Salát, Milos Matkovic, Petr Bednář, Pavel Novotný, Martin Hradilek, Taťána Majerová, Ebba Rosendal, Luděk Eyer, Andrea Fořtová, Michaela Beránková, Lesley Bell-Sakyi, Anna K. Överby, Andrea Cavalli, Massimiliano Bonomi, Félix A. Rey, Daniel Růžek

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PubMed ID: 40796726

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The cAMP-PKA signaling initiates mitosis by phosphorylating Bora

Authors: Min Zhu, Shinan Zhou, Yingqi Zhang, Qinfu Chen, Xueying Yuan, Long Zhang, Haiyan Yan, Fangwei Wang

Journal: Nature Communications

PubMed ID: 40849432

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Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease

Authors: Runchuan Yan, Yan Zhang, Jingjing Zhang, Xiangyi Zhang, Yue Han, Mengfei Wang, Dan Wang, Shengnan Huang, Wei Liu, Qi Shi, Xiaoping Dong, Wen-Quan Zou, Zhen Li, Jiyan Ma

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PubMed ID: 40768577

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Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA

Authors: De-Ping Wang, Rong Zhao, Wen-Shu Hu, Hai-Ning Li, Ji-Min Cao, Xin Zhou, Ye Xiang

Journal: Nature Communications

PubMed ID: 40775214

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Quantifying collective interactions in biomolecular phase separation

Authors: Hannes Ausserwöger, Ella de Csilléry, Daoyuan Qian, Georg Krainer, Timothy J Welsh, Tomas Sneideris, Titus M Franzmann, Seema Qamar, Nadia A Erkamp, Jonathon Nixon-Abell, Mrityunjoy Kar, Peter St George-Hyslop, Anthony A Hyman, Simon Alberti, Rohit V Pappu, Tuomas P J Knowles

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PubMed ID: 40830100

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Optimised modular anti‐FLAG CAR T cells for solid tumor therapy

Authors: Xiaomeng Zhang, Rachel Xu, Dmitry Zorin, Evan G Pappas, Jiawei Tang, Yuchen Bai, Vicky M Qin, Bianca von Scheidt, Ruihong Huang, Weronika Kulakowska, Charbel Darido, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal: Clinical & Translational Immunology

PubMed ID: 40851786

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