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Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium

Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti

Journal: Int J Biol Macromol

PubMed ID: 38944065

Doi: 10.1016/j.ijbiomac.2024.133449

Products & Services: Gene Synthesis

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis

Authors: Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang

Journal: Free Radic Biol Med

PubMed ID: 38945457

Doi: 10.1016/j.freeradbiomed.2024.06.025

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Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis

Authors: Jianwei Liu, Dixing Lin, Jiadong Lu

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 38836662

Doi: 10.14715/cmb/2024.70.6.29

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Characterization of a novel carboxylesterase from Streptomyces lividans TK24 and site-directed mutagenesis for its thermostability

Authors: Jinxin Fang, Lihua An, Jiao Yu, Jinxue Ma, Rongjie Zhou, Baojuan Wang

Journal: J Biosci Bioeng

PubMed ID: 38871580

Doi: 10.1016/j.jbiosc.2024.05.001

Products & Services: Proteins, Expression, Isolation and Analysis

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG antibodies

Authors: Wen-Ting K Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J Carter

Journal: MAbs

PubMed ID: 38845069

Doi: 10.1080/19420862.2024.2362789

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Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

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Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

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Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Proteins, Expression, Isolation and Analysis

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Proteins, Expression, Isolation and Analysis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

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Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

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AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Proteins, Expression, Isolation and Analysis

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

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Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Proteins, Expression, Isolation and Analysis

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

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Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming

Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding

Journal: Adv Sci (Weinh)

PubMed ID: 38923275

Doi: 10.1002/advs.202309314

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens

Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun

Journal: Marine Life Science & Technology

Doi: //doi.org/10.1007/s42995-024-00237-x

Products & Services: Proteins, Expression, Isolation and Analysis

Self-assembled protein vesicles as vaccine delivery platform to enhance antigen-specific immune responses

Authors: Yirui Li, Mariela R Rodriguez-Otero, Julie A Champion

Journal: Biomaterials

PubMed ID: 38879893

Doi: 10.1016/j.biomaterials.2024.122666

Products & Services: Molecular Biology Reagents

Expanding the genetic toolbox for the obligate human pathogen

Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier

Journal: Front Bioeng Biotechnol

PubMed ID: 38911550

Doi: 10.3389/fbioe.2024.1395659

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Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases

Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth

Journal: Pancreatology

PubMed ID: 38876922

Doi: 10.1016/j.pan.2024.06.003

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Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Authors: Jay Kumar, Renu A Kowluru

Journal: Mitochondrion

PubMed ID: 38944370

Doi: 10.1016/j.mito.2024.101925

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An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor

Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang

Journal: J Agric Food Chem

PubMed ID: 38847536

Doi: 10.1021/acs.jafc.4c02968

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APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang

Journal: Cell Mol Biol Lett

PubMed ID: 38867189

Doi: 10.1186/s11658-024-00600-x

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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem

Journal: biorxiv

PubMed ID: 38948822

Doi: 10.1101/2024.06.18.599616

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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan

Journal: Stem Cell Res Ther

PubMed ID: 38926849

Doi: 10.1186/s13287-024-03792-3

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CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy

Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian

Journal: Blood Adv

PubMed ID: 38564778

Doi: 10.1182/bloodadvances.2023012202

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Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland

Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen

Journal: Microb Biotechnol

PubMed ID: 38829370

Doi: 10.1111/1751-7915.14466

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Comparative Analysis of Orthosteric and Allosteric GLP-1R Agonists' Effects on Insulin Secretion from Healthy, Diabetic, and Recovered INS-1E Pancreatic Beta Cells

Authors: Joshua Reed, Victoria Higginbotham, Stephen Bain, Venkateswarlu Kanamarlapudi

Journal: Int J Mol Sci

PubMed ID: 38928038

Doi: 10.3390/ijms25126331

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Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography

Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu

Journal: J Chromatogr A

PubMed ID: 38905946

Doi: 10.1016/j.chroma.2024.465107

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The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats

Authors: Xin Fang, Richa Tiwary, Vivian P Nguyen, John H Richburg

Journal: Toxicol Sci

PubMed ID: 38565259

Doi: 10.1093/toxsci/kfae043

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Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins

Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza

Journal: Anticancer Res

PubMed ID: 38821612

Doi: 10.21873/anticanres.17062

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

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A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu

Journal: J Sep Sci

PubMed ID: 38819782

Doi: 10.1002/jssc.202400090

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Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

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Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu

Journal: Nat Biomed Eng

PubMed ID: 38858586

Doi: 10.1038/s41551-024-01227-1

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Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma

Authors: Kalibixiati Aimulajiang, Wen Chu, Shuyi Liao, Zhaohai Wen, Rongdong He, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: Immun Inflamm Dis

PubMed ID: 38888451

Doi: 10.1002/iid3.1321

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Molecular Mechanism of GmSNE3 Ubiquitin Ligase-Mediated Inhibition of Soybean Nodulation by Halosulfuron Methyl

Authors: Yuanfu Li, Jingsi Qiu, Jingxia Yang, Yihan Li, Hui Zhang, Feng Zhao, Huihua Tan

Journal: J Agric Food Chem

PubMed ID: 38867659

Doi: 10.1021/acs.jafc.4c02621

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi

Journal: medrxiv

PubMed ID: 38883797

Doi: 10.1101/2024.06.02.24308281

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Identification of two novel B cell epitopes on E184L protein of African swine fever virus using monoclonal antibodies

Authors: Weldu Tesfagaber, Desong Lan, Wan Wang, Rui Zhao, Li Yin, Mingyang Yang, Yuanmao Zhu, Encheng Sun, Renqiang Liu, Wenjun Lin, Zhigao Bu, Fang Li, Dongming Zhao

Journal: Virus Res

PubMed ID: 38838820

Doi: 10.1016/j.virusres.2024.199412

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Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation

Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu

Journal: J Virol

PubMed ID: 38869285

Doi: 10.1128/jvi.00561-24

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of procyanidin condensed tannins of (-)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2

Authors: Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Journal: Int J Biol Macromol

PubMed ID: 38866269

Doi: 10.1016/j.ijbiomac.2024.133059

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GhMPK9-GhRAF39_1-GhWRKY40a Regulates the GhERF1b- and GhABF2-Mediated Pathways to Increase Cotton Disease Resistance

Authors: Xinyue Mi, Weixi Li, Chuan Chen, Huijuan Xu, Guilin Wang, Xuanxiang Jin, Dayong Zhang, Wangzhen Guo

Journal: Adv Sci (Weinh)

PubMed ID: 38845189

Doi: 10.1002/advs.202404400

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A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

Authors: Xiaoqing Guan, Abhishek K Verma, Gang Wang, Abhijeet Roy, Stanley Perlman, Lanying Du

Journal: Vaccines (Basel)

PubMed ID: 38932334

Doi: 10.3390/vaccines12060605

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Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

Authors: Satyajit Mahapatra, Tomoyuki Takahashi

Journal: Elife

PubMed ID: 38829367

Doi: 10.7554/eLife.90497

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A novel xylanase from a myxobacterium triggers a plant immune response in Nicotiana benthamiana

Authors: Yuqiang Zhao, Kun Yang, Yanxin Wang, Xu Li, Chengyao Xia, Yan Huang, Zhoukun Li, Cancan Zhu, Zhongli Cui, Xianfeng Ye

Journal: Mol Plant Pathol

PubMed ID: 38924248

Doi: 10.1111/mpp.13488

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Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization

Authors: Benjamin M Janus, Ruixue Wang, Thomas E Cleveland, Matthew C Metcalf, Aaron C Lemmer, Nydia van Dyk, Sarah Jeong, Anagh Astavans, Kenneth Class, Thomas R Fuerst, Gilad Ofek

Journal: J Virol

PubMed ID: 38832790

Doi: 10.1128/jvi.00155-24

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A self-healing multispectral transparent adhesive peptide glass

Authors: Gal Finkelstein-Zuta, Zohar A Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit

Journal: Nature

PubMed ID: 38867128

Doi: 10.1038/s41586-024-07408-x

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The BEL1-like homeodomain protein OsBLH4 regulates rice plant height, grain number, and heading date by repressing the expression of OsGA2ox1

Authors: Chengjuan Cao, Shuaiqiang Guo, Ping Deng, Shiyi Yang, Jing Xu, Tengfei Hu, Zhijuan Hu, Di Chen, Hongsheng Zhang, Ian Paul Navea, Joong Hyoun Chin, Wenhua Zhang, Wen Jing

Journal: Plant J

PubMed ID: 38824648

Doi: 10.1111/tpj.16857

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Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

Authors: Salinthip Jarusintanakorn, Enrico Mastrobattista, Montarop Yamabhai

Journal: N Biotechnol

PubMed ID: 38945523

Doi: 10.1016/j.nbt.2024.06.006

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CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis

Authors: Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi-Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen

Journal: Adv Sci (Weinh)

PubMed ID: 38873823

Doi: 10.1002/advs.202400611

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Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Abraham O Oluwole, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Macie S Sheridan, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: EMBO J

PubMed ID: 38839991

Doi: 10.1038/s44318-024-00132-2

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis

Authors: Ross M Walker, Minquan Zhang, Robert L Burnap

Journal: Biochim Biophys Acta Bioenerg

PubMed ID: 38906312

Doi: 10.1016/j.bbabio.2024.149149

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Recovery kinetics of dual AAV-mediated human otoferlin expression

Authors: Jonathan B Sellon, Kathy S So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C Drummond, Peter G Slade, Ning Pan, Tyler M Gibson, Tian Yang, Joseph C Burns, Adam T Palermo, Lars Becker

Journal: Front Mol Neurosci

PubMed ID: 38952419

Doi: 10.3389/fnmol.2024.1376128

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Boosting PRRSV-Specific Cellular Immunity: The Immunological Profiling of an Fc-Fused Multi-CTL Epitope Vaccine in Mice

Authors: Xinnuo Lei, Jinzhao Ban, Zhi Wu, Shinuo Cao, Mo Zhou, Li Zhang, Rui Zhu, Huipeng Lu, Shanyuan Zhu

Journal: Vet Sci

PubMed ID: 38922021

Doi: 10.3390/vetsci11060274

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Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

Authors: Ju-Fang Chang, Nils Wellhausen, Nils Wolfgang Engel, Jack H Landmann, Caitlin R Hopkins, January Salas-McKee, Adham S Bear, Mehmet Emrah Selli, Sangya Agarwal, Julie Jadlowsky, Gerald P Linette, Saar Gill, Carl H June, Joseph A Fraietta, Nathan Singh

Journal: Cancer Immunol Res

PubMed ID: 38869428

Doi: 10.1158/2326-6066.CIR-24-0251

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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

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One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

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DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Authors: Shin-Ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko

Journal: Commun Biol

PubMed ID: 38834758

Doi: 10.1038/s42003-024-06297-0

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Capturing totipotency in human cells through spliceosomal repression

Authors: Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, Peng Du

Journal: Cell

PubMed ID: 38843832

Doi: 10.1016/j.cell.2024.05.010

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NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

Authors: Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Freour, Louis Chauviere, Carla Piqueras, Ruben Boers, Joachim Boers, Joost Gribnau, Laurent David, Jean-François Ouimette & Claire Rougeulle

Journal: Nat Struct Mol Biol

PubMed ID: 38834912

Doi: 10.1038/s41594-024-01325-3

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Characterization and regulation of cell cycle-independent noncanonical gene targeting

Authors: Shinta Saito & Noritaka Adachi

Journal: Nature Communications

PubMed ID: 38890315

Doi: 10.1038/s41467-024-49385-9.

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex

Authors: Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang & Zengqin Deng

Journal: Cell Research

PubMed ID: 38834762

Doi: 10.1038/s41422-024-00981-w

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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

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Enhanced Recombinant Protein Expression in Insect Cells by Natural and Recombinant Components of Lepidoptera Hemolymph

Authors: Javier López-Vidal, Susana Martínez-Pulgarín, Diego Martínez-Alonso, Miguel Cid, José M Escribano

Journal: Viruses

PubMed ID: 38932236

Doi: 10.3390/v16060944

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A quadrivalent recombinant influenza Hemagglutinin vaccine induced strong protective immune responses in animal models

Authors: Jin Feng, Yingying Du, Liyun Chen, Wenhan Su, Hailiu Wei, Aijiao Liu, Xiaojun Jiang, Jianmin Guo, Cailing Dai, Yuhua Xu, Tao Peng

Journal: Vaccine

PubMed ID: 38834431

Doi: 10.1016/j.vaccine.2024.05.056

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Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Authors: Yuanwei Gou, Dongfang Li, Minghui Zhao, Mengxin Li, Jiaojiao Zhang, Yilian Zhou, Feng Xiao, Gaofei Liu, Haote Ding, Chenfan Sun, Cuifang Ye, Chang Dong, Jucan Gao, Di Gao, Zehua Bao, Lei Huang, Zhinan Xu, Jiazhang Lian

Journal: Nat Commun

PubMed ID: 38898098

Doi: 10.1038/s41467-024-49554-w

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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly

Journal: Structure

PubMed ID: 38870939

Doi: 10.1016/j.str.2024.05.011

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Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu

Journal: Pharmaceutics

PubMed ID: 38931944

Doi: 10.3390/pharmaceutics16060824

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Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma

Journal: Microb Cell Fact

PubMed ID: 38879464

Doi: 10.1186/s12934-024-02453-7

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Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda

Journal: J Biol Chem

PubMed ID: 38879015

Doi: 10.1016/j.jbc.2024.107464

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Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma

Journal: Clinics (Sao Paulo)

PubMed ID: 38901133

Doi: 10.1016/j.clinsp.2024.100410

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SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Journal: Vaccines (Basel)

PubMed ID: 38932392

Doi: 10.3390/vaccines12060663

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PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2

Authors: Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito

Journal: Sci Rep

PubMed ID: 38844490

Doi: 10.1038/s41598-024-63239-w

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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns

Authors: Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco

Journal: RNA

PubMed ID: 38575347

Doi: 10.1261/rna.079933.123

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Discovery of Monovalent Direct Degraders of BRD4 That Act Via the Recruitment of DCAF11

Authors: Gregory S Parker, Julia I Toth, Sarah Fish, Gabrielle A Blanco, Taylor Kampert, Xiaoming Li, Linette Yang, Craig R Stumpf, Kenneth Steadman, Aleksandar Jamborcic, Stephen Chien, Elizabeth Daniele, Alejandro Dearie, Geoffray Leriche, Simon Bailey, Peggy A Thompson

Journal: Mol Cancer Ther

PubMed ID: 38907538

Doi: 10.1158/1535-7163.MCT-24-0219

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Molecular Mechanism of WWOX Inhibiting the Development of Esophageal Cancer by Inhibiting Hippo Signaling Pathway

Authors: Zihan Chen, Jingyu Sun, Lili Zhang, Yanglin Sun, Qingqing Ni, Hongkun Zhu, Miao Hui, Longzhen Zhang, Qiang Wang

Journal: Biochem Genet

PubMed ID: 38902482

Doi: 10.1007/s10528-024-10856-9

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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity

Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee

Journal: J Allergy Clin Immunol

PubMed ID: 38878020

Doi: 10.1016/j.jaci.2024.03.029

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Integration of Image Pattern Recognition and Photon Sensor for Analyzing Cytokine Gene Expression Using πCode MicroDisc

Authors: On-Anong Juntit, Kanokporn Sornsuwan, Umpa Yasamut, Chatchai Tayapiwatana

Journal: Biosensors (Basel)

PubMed ID: 38920610

Doi: 10.3390/bios14060306

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High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling

Authors: Jayati Gera, Dheeraj Kumar, Gunjan Chauhan, Adarsh Choudhary, Lavi Rani, Lolitika Mandal, Sudip Mandal

Journal: J Cell Biol

PubMed ID: 38916917

Doi: 10.1083/jcb.202306087

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Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles

Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei

Journal: Macromol Rapid Commun

PubMed ID: 38923127

Doi: 10.1002/marc.202400173

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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning

Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos

Journal: Tumour Virus Res

PubMed ID: 38909779

Doi: 10.1016/j.tvr.2024.200287

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Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesion Ability

Authors: Yuanxing Shi, Yun Xu, Longyu Zhang, Yunjun Yan, Jinyong Yan

Journal: ACS Appl Bio Mater

PubMed ID: 38926913

Doi: 10.1021/acsabm.4c00455

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis

Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan

Journal: Biochem Biophys Res Commun .

PubMed ID: 38626621

Doi: 10.1016/j.bbrc.2024.149934

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A growth selection system for sucrose synthases (SuSy): design and test

Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner

Journal: AMB Express

PubMed ID: 38865019

Doi: 10.1186/s13568-024-01727-y

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BRET-based biosensors for SARS-CoV-2 oligonucleotide detection

Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas

Journal: Front Bioeng Biotechnol

PubMed ID: 38887615

Doi: 10.3389/fbioe.2024.1353479

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Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Journal: Nat Commun

PubMed ID: 38890271

Doi: 10.1038/s41467-024-49041-2

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The role of shear forces in primary and secondary nucleation of amyloid fibrils

Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38875148

Doi: 10.1073/pnas.2322572121

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The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis

Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem

Journal: G3 (Bethesda)

PubMed ID: 38839055

Doi: 10.1093/g3journal/jkae122

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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

Journal: PLoS Pathog

PubMed ID: 38829892

Doi: 10.1371/journal.ppat.1012289

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