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Reversible control of kinase signaling through chemical-induced dephosphorylation

Authors: Ying Sun , Rihong Zhou , Jin Hu , Shan Feng , Qi Hu

Journal: Communications Biology

PubMed ID: 39217250

Doi: 10.1038/s42003-024-06771-9

Products & Services: Proteins, Expression, Isolation and Analysis Recombinant Proteins

Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent

Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu

Journal: Bioactive Materials

Doi: doi.org/10.1016/j.bioactmat.2024.07.028

Products & Services: Peptide Synthesis

Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein

Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery

Journal: Protein Sci

PubMed ID: 38864725

Doi: 10.1002/pro.5038

Products & Services: Molecular Biology Reagents

The strongest protein binder is surprisingly labile

Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez

Journal: Protein Sci

PubMed ID: 38864696

Doi: 10.1002/pro.5030

Products & Services: Molecular Biology Reagents

Fluorinated Titanium Oxide (TiO2-xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

Authors: Shumin Sun , Xuan Huang , Nailin Yang , Huali Lei , Zifan Pei , Zhihui Han , Lin Liu , Fei Gong , Qiao Yu , Jingrui Li , Youdong Chen , Liang Cheng

Journal: ACS Nano

PubMed ID: 39010657

Doi: 10.1021/acsnano.4c05448

Products & Services: Proteins, Expression, Isolation and Analysis

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Authors: Michael J Peluso, Dylan Ryder, Robert R Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare, Maya Aslam, Walter Koch, Gyula Szabo, Rebecca Hoh, Monika Deswal, Antonio E Rodriguez, Melissa Buitrago, Viva Tai, Uttam Shrestha, Scott Lu, Sarah A Goldberg, Thomas Dalhuisen, Joshua J Vasquez, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Nitasha Kumar, Jeffrey N Martin, Aruna Gambhir, Ma Somsouk, Youngho Seo, Steven G Deeks, Zoltan G Laszik, Henry F VanBrocklin, Timothy J Henrich

Journal: Sci Transl Med

PubMed ID: 38959327

Doi: 10.1126/scitranslmed.adk3295

Products & Services: Molecular Biology Reagents

Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Authors: Everardo R Rodriguez Rodriguez, Rune Thorbjørn Nordvang, Marcus Petersson, Jakob Kræmmer Haar Rendsvig, Emma Wenzel Arendrup, Monica L Fernández Quintero, Timothy P Jenkins, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Protein Sci

PubMed ID: 38923049

Doi: 10.1002/pro.5035

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering psychrophilic polymerase for nanopore long-read sequencing

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Bioeng Biotechnol

PubMed ID: 39011153

Doi: 10.3389/fbioe.2024.1406722

Products & Services: PCR Cloning and Subcloning

Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ

Authors: Souradeep Banerjee, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar

Journal: Protein Sci

PubMed ID: 38864739

Doi: 10.1002/pro.5068

Products & Services: Molecular Biology Reagents

Improvement and application of vacuum-infiltration system in tomato

Authors: Xinghao Yao, Ayat Taheri, Hang Liu, Yaojie Zhang, Ling Li, Jin Shao, Ke Wu, Qing Miao, Weizhi He, Xinyi Hu, Kexuan Tang

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhae197

Products & Services: Plasmid DNA Preparation

Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer

Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri

Journal: Mol Cancer Ther

PubMed ID: 38638035

Doi: 10.1158/1535-7163.MCT-23-0766

Products & Services: Gene Synthesis

Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system

Authors: Danping Zhang 1, Liyang Du 1, Haishan Gao 2 3, Cai Yuan 4, Zhonghui Lin 1

Journal: Nucleic Acids Res

PubMed ID: 38967023

Doi: 10.1093/nar/gkae569

Products & Services: Gene Synthesis

The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis

Authors: Lei Shi, Changjiang Li, Gaofeng Lv, Xing Li, Wutao Feng, Yujing Bi, Wenhui Wang, Youqun Wang, Lei Zhu, Wenqiang Tang, Ying Fu

Journal: Plant Cell

PubMed ID: 38526222

Doi: 10.1093/plcell/koae086

Products & Services: Gene Synthesis

Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax

Authors: Yi Cao 1, Clifford T H Hayashi , Maisa da Silva Araujo , Abhai K Tripathi , Alice Oliveira Andrade , Jansen Fernandes Medeiros , Joseph Vinetz & Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39033079

Doi: 10.1016/j.vaccine.2024.07.041

Products & Services: Codon Optimization

Cytochrome b5 diversity in green lineages preceded the evolution of syringyl lignin biosynthesis

Authors: Xianhai Zhao, Yunjun Zhao, Qing-Yin Zeng, Chang-Jun Liu

Journal: Plant Cell

PubMed ID: 38657101

Doi: 10.1093/plcell/koae120

Products & Services: Gene Synthesis

Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale

Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin

Journal: Cell

PubMed ID: 38936359

Doi: 10.1016/j.cell.2024.05.056

Products & Services: Custom RNAi Services

Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue

Journal: biorxiv

Doi: 2024.07.26.605286

Products & Services: Gene Synthesis

Impact of Equilibrative Nucleoside Transporters TgAT1, TgENT1, and TgENT3 on Toxoplasma gondii Infection and Differentiation

Authors: Amber Goerner, Gabriel Messina, Lea Drogalis Beckham, Bruno Martorelli Di Genova

Journal: biorxiv

Doi: doi.org/10.1101/2024.07.10.601519

Products & Services: Gene Synthesis

Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum

Authors: Zhengjie Wang, Ruili Lv, Chenglin Su, Yan Li, Sizhe Fang, Ruirui Yang, Jiaxuan Zhu, Ruiming Wang, Jun Meng, Yushi Luan

Journal: J Agric Food Chem

PubMed ID: 38994823

Doi: 10.1021/acs.jafc.4c03588

Products & Services: Peptide Synthesis

Comparative biochemistry of PET hydrolase-carbohydrate-binding module fusion enzymes on a variety of PET substrates

Authors: Andrew Philip Rennison , Andreas Prestel , Peter Westh , Marie Sofie Møller

Journal: Enzyme and Microbial Technology

PubMed ID: 39047349

Doi: 10.1016/j.enzmictec.2024.110479

Products & Services: Gene Synthesis Mutagenesis Services

Mechanism of ceramide synthase inhibition by fumonisin B1

Authors: Zike Zhang 1 2 4, Qi Fang 1 2 4, Tian Xie 1 2, Xin Gong

Journal: Structure

Doi: 10.1016/j.str.2024.06.002

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

Authors: Moisés Alejandro Alejo Hernandez , Katia Pamela Villavicencio Sánchez , Rosendo Sánchez Morales , Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez , Eddie Guillermo Sanchez-Rueda , Yanet Teresa-Cruz , Brian Choi, Armando Hernández Garcia , Alba Romero-Rodríguez, Oscar Juárez , Siseth Martínez-Caballero , Mario Figueroa , Corina-Diana Ceapă

Journal: Beilstein Journal of Organic Chemistry

PubMed ID: 39109298

Doi: 10.3762/bjoc.20.159

Products & Services: Gene Synthesis

Acceptors stability modulates the efficiency of post-translational protein N-glycosylation

Authors: Paula M Couto, Carlos M A Guardia, Facundo L Couto, Carlos A Labriola, María S Labanda, Julio J Caramelo

Journal: FASEB J

PubMed ID: 38934375

Doi: 10.1096/fj.202302267R

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Integration of validated functional evidence to support the pathogenicity of KCNH2 variants

Authors: Reema W Aljassar, Qianyi Shen, Buthaina Albash, Jamie I Vandenberg, Mohammad A Ebrahim, Chai-Ann Ng

Journal: Genet Med Open

PubMed ID: 39669639

Doi: 10.1016/j.gimo.2024.101868

Products & Services: Gene Synthesis

Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner

Authors: Lin-Chao Yu, Rui He, Dao-Xin Wang, Di Qi

Journal: Am J Respir Cell Mol Biol

PubMed ID: 38574235

Doi: 10.1165/rcmb.2024-0017OC

Products & Services: Molecular Biology Reagents

METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA

Authors: Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu

Journal: Hereditas

PubMed ID: 38956710

Doi: 10.1186/s41065-024-00317-z

Products & Services: Mutant Libraries

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Authors: Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn

Journal: J Mol Cell Biol

PubMed ID: 38253401

Doi: 10.1093/jmcb/mjae003

Products & Services: Mutant Libraries

Screening L-Lysine-Overproducing Escherichia coli Using Artificial Rare Codons and a Rare Codon-Rich Marker

Authors: Shen Li , Tianhao Xu , Xinru Meng , Yujuan Yan , Ying Zhou , Lei Duan , Yulong Tang , Li Zhu & Litao Sun

Journal: Nucleic Acids Research

PubMed ID: 38989624

Doi: doi.org/10.3390/

Products & Services: Gene Synthesis

DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants

Authors: Bingbing Yu , Yifan Chen , Yan Yan , Xueling Lu , Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38979568

Doi: 10.1093/nar/gkae593

Products & Services: Gene Services

Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Authors: Yan Wang , Jing Zhang , Ying Liu , Xiao Yue , Kun Han , Zhichao Kong , Yuanmin Dong , Zhenmei Yang , Zhipeng Fu , Chunwei Tang , Chongdeng Shi , Xiaotian Zhao , Maosen Han , Zhibin Wang , Yulin Zhang , Chen Chen , Anning Li , Peng Sun , Danqing Zhu , Kun Zhao , Xinyi Jiang

Journal: Sci Adv

PubMed ID: 38865465

Doi: 10.1126/sciadv.ado4791

Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices

Authors: Yuxiang Liu, Ruixuan Wang, Qimingxing Chen, Yan Chang, Qi Chen, Kodai Fukumoto, Bingxun Wang, Jianchen Yu, Changfeng Luo, Jiayuan Ma, Xiaoxia Chen, Yuko Murayama, Kenichi Umeda, Noriyuki Kodera, Yoshie Harada, Shun-Ichi Sekine, Jianfeng Li, Hisashi Tadakuma

Journal: NANO LETTERS

PubMed ID: 38920331

Doi: 10.1021/acs.nanolett.4c02104

Products & Services: Custom DNA/RNA Oligos

A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7

Authors: Christian J Muñoz Sosa , Christopher Lenz , Anton Hamann , Frederic Farges , Johannes Dopfer , Andreas Krämer , Veronika Cherkashyna , Andrey Tarnovskiy , Yurii S Moroz , Ewgenij Proschak , Václav Němec , Susanne Müller , Krishna Saxena , Stefan Knapp

Journal: ACS Chem Biol

PubMed ID: 38934237

Doi: 10.1021/acschembio.4c00301

Products & Services: Gene Synthesis

Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals

Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang

Journal: Small Methods

PubMed ID: 38864527

Doi: 10.1002/smtd.202400664

Products & Services: Molecular Biology Reagents

Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

Authors: Huasong Ai , Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol

PubMed ID: 38918638

Doi: doi.org/10.1038/s41594-024-01342-2

Products & Services: Codon Optimization

The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart

Authors: Elena Tsisanova, Muriel Nobles, Sonia Sebastian, Keat-Eng Ng, Alison Thomas, Lee Scott Weinstein, Patricia B Munroe, Andrew Tinker

Journal: J Biol Chem

PubMed ID: 38879012

Doi: 10.1016/j.jbc.2024.107470

Products & Services: Molecular Biology Reagents

Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins

Authors: Piotr Kolesiński, Matthew McGowan, Anne Botteaux, Pierre R Smeesters, Partho Ghosh

Journal: J Biol Chem

PubMed ID: 38879009

Doi: 10.1016/j.jbc.2024.107478

Products & Services: Proteins, Expression, Isolation and Analysis

Synthetic genomes unveil the effects of synonymous recoding

Authors: Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Dawn Chen, Jenny Ahn, Owen Spencer, Venkat Ayalavarapu, Angela Tarver, Miranda Harmon-Smith, Matthew Hamilton, Ian Blaby, Yasuo Yoshikuni, Behnoush Hajian, Adeline Jin, Balint Kintses, Monika Szamel, Viktoria Seregi, Yue Shen, Zilong Li, George M Church

Journal: biorxiv

PubMed ID: 38915524

Doi: 10.1101/2024.06.16.599206

Products & Services: Gene Synthesis

The Human Genetic Differences in the Outcomes of mRNA Vaccination against COVID-19: A Prospective Cohort Study

Authors: Ha-Eun Ryu, Jihyun Yoon, Ja-Eun Choi, Seok-Jae Heo, Kyung-Won Hong, Dong-Hyuk Jung

Journal: Vaccines (Basel)

PubMed ID: 38932355

Doi: 10.3390/vaccines12060626

Products & Services: Molecular Biology Reagents

PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation

Authors: Antonio Ruiz-Albor, Belén Chaves-Arquero, Inés Martín-Barros, Alejandra Guerra-Castellano, Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Nekane Merino, Mariola Ferreras-Gutiérrez, Edurne Berra, Irene Díaz-Moreno, Francisco J Blanco

Journal: Int J Biol Macromol

PubMed ID: 38880460

Doi: 10.1016/j.ijbiomac.2024.133187

Products & Services: Proteins, Expression, Isolation and Analysis

Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline

Authors: Brenna Norton-Baker, Mackenzie C R Denton, Natasha P Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P Gauthier, Gregg T Beckham

Journal: Sci Rep

PubMed ID: 38914665

Doi: 10.1038/s41598-024-64938-0

Products & Services: Proteins, Expression, Isolation and Analysis

Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression

Authors: Jun-Sheng Ni, Si-Yuan Fu, Zong-Yan Wang, Wen-Bin Ding, Jian Huang, Xing-Gang Guo, Fang-Ming Gu

Journal: J Gene Med

PubMed ID: 38860366

Doi: 10.1002/jgm.3693

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14

Authors: Drayson Graves, Nikolas Akkerman, Lauren Fulham, Rafe Helwer, Peter Pelka

Journal: MBio

PubMed ID: 38940561

Doi: 10.1128/mbio.01038-24

Products & Services: Proteins, Expression, Isolation and Analysis

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

Authors: Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan

Journal: biorxiv

PubMed ID: 38895352

Doi: 10.1101/2024.06.04.597282

Products & Services: Proteins, Expression, Isolation and Analysis

In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade

Authors: Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu

Journal: Immunol Lett

PubMed ID: 38925442

Doi: 10.1016/j.imlet.2024.106887

Products & Services: Proteins, Expression, Isolation and Analysis

RcOST1L phosphorylates RcPIF4 for proteasomal degradation to promote flowering in rose

Authors: Jingjing Sun, Hongchi Liu, Weinan Wang, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jun Lu, Jinyi Liu, Changquan Wang

Journal: New Phytol

PubMed ID: 38849320

Doi: 10.1111/nph.19885

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Characterization of Two Glycoside Hydrolases of Family GH13 and GH57, Present in a Polysaccharide Utilization Locus (PUL) of sp SGAir0037

Authors: Hilda Hubertha Maria Bax, Edita Jurak

Journal: Molecules

PubMed ID: 38930854

Doi: 10.3390/molecules29122788

Products & Services: Molecular Biology Reagents

Metal binding feature of copper‒induced metallothionein from freshwater crab Sinopotamon henanense reveals its Cu‒thionein character

Authors: Huizhen Yang, Ziyan Zhao, Hongquan Li, Lan Wang

Journal: Protein Expr Purif

PubMed ID: 38830441

Doi: 10.1016/j.pep.2024.106519

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Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing

Authors: Yaoqi Sun, Bing Xiong, Xueqian Shuai, Jiale Li, Chunyan Wang, Jing Guo, Zhongping Cheng, Shupeng Liu

Journal: Mol Med

PubMed ID: 38867190

Doi: 10.1186/s10020-024-00849-0

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Surface functionalization of virus-like particles via bioorthogonal click reactions for enhanced cell-specific targeting

Authors: Chavee Laomeephol, Supannikar Tawinwung, Koramit Suppipat, Wanatchaporn Arunmanee, Qian Wang, Jittima Amie Luckanagul

Journal: Int J Pharm

PubMed ID: 38866085

Doi: 10.1016/j.ijpharm.2024.124332

Products & Services: Proteins, Expression, Isolation and Analysis

Developing deprotectase biocatalysts for synthesis

Authors: Lisa Kennedy, Mariyah Sajjad, Michael A Herrera, Peter Szieber, Natasza Rybacka, Yinan Zhao, Craig Steven, Zainab Alghamdi, Ivan Zlatkov, Julie Hagen, Chloe Lauder, Natalie Rudolfova, Magdalena Abramiuk, Karolina Bolimowska, Daniel Joynt, Angelica Lucero, Gustavo Perez Ortiz, Annamaria Lilienkampf, Alison N Hulme, Dominic J Campopiano

Journal: Faraday Discuss

PubMed ID: 38856717

Doi: 10.1039/d4fd00016a

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Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

Authors: Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang

Journal: Mol Med

PubMed ID: 38867145

Doi: 10.1186/s10020-024-00854-3

Products & Services: Proteins, Expression, Isolation and Analysis

MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Authors: Yen-Nien Liu, Wei-Yu Chen, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Phan Vu Thuy Dung, Zi-Qing Chen, Wei-Jiunn Lee, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen

Journal: Sci Signal

PubMed ID: 38861615

Doi: 10.1126/scisignal.adc9142

Products & Services: Proteins, Expression, Isolation and Analysis

Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis

Authors: Elisa Perez-Moreno, Tomás Toledo, Pascale Campusano, Sebastián Zuñiga, Lorena Azócar, Teo Feuerhake, Gonzalo P Méndez, Mariana Labarca, Francisca Pérez-Molina, Adely de la Peña, Cristian Herrera-Cid, Pamela Ehrenfeld, Alejandro S Godoy, Alfonso González, Andrea Soza

Journal: Biomed Pharmacother

PubMed ID: 38936192

Doi: 10.1016/j.biopha.2024.116923

Products & Services: Proteins, Expression, Isolation and Analysis

Unveiling of the Co-Infection of Peste des Petits Ruminants Virus and Caprine Enterovirus in Goat Herds with Severe Diarrhea in China

Authors: Qun Zhang, Xuebo Zheng, Fan Zhang, Xuyuan Cui, Naitian Yan, Junying Hu, Yidi Guo, Xinping Wang

Journal: Viruses

PubMed ID: 38932277

Doi: 10.3390/v16060986

Products & Services: Proteins, Expression, Isolation and Analysis

Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth

Authors: Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer

Journal: Cell Death Differ

PubMed ID: 38858548

Doi: 10.1038/s41418-024-01319-0

Products & Services: Molecular Biology Reagents

Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody

Authors: Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-Anong Juntit, Umpa Yasamut, Nuchjira Takheaw, Watchara Kasinrerk, Phenphichar Wanachantararak, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Nutjeera Intasai, Chatchai Tayapiwatana

Journal: Int J Mol Sci

PubMed ID: 38928332

Doi: 10.3390/ijms25126626

Products & Services: Codon Optimization

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Authors: Desmond Richmond-Buccola, Samuel J Hobbs, Jasmine M Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S Y Lee, Philip J Kranzusch

Journal: Cell Host Microbe

PubMed ID: 38917809

Doi: 10.1016/j.chom.2024.05.021

Products & Services: Proteins, Expression, Isolation and Analysis

Dissecting the dynamics of SARS-CoV-2 reinfections in blood donors with pauci- or asymptomatic COVID-19 disease course at initial infection

Authors: Alexandra Domnica Hoeggerl, Verena Nunhofer, Lisa Weidner, Wanda Lauth, Georg Zimmermann, Natalie Badstuber, Christoph Grabmer, Orkan Kartal, Christof Jungbauer, Heidrun Neureiter, Nina Held, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger

Journal: Infect Dis (Lond)

PubMed ID: 38869944

Doi: 10.1080/23744235.2024.2367112

Products & Services: Proteins, Expression, Isolation and Analysis

Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset

Authors: Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudio Franceschi, Ivan Doykov, Justyna Śpiewak, Héloїse Vinette, Claudia Trenkwalder, Wendy E Heywood, Kevin Mills, Brit Mollenhauer

Journal: Nat Commun

PubMed ID: 38890280

Doi: 10.1038/s41467-024-48961-3

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SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution

Authors: Yao Yao, Zhiwei Zhou, Xiaoling Wang, Zhirui Liu, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue, Shuquan Rao

Journal: Cell Genom

PubMed ID: 38889719

Doi: 10.1016/j.xgen.2024.100583

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

Authors: Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens

Journal: Nat Struct Mol Biol

PubMed ID: 38918639

Doi: 10.1038/s41594-024-01338-y

Products & Services: Gene Synthesis

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Authors: Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde

Journal: Nat Metab

PubMed ID: 38871982

Doi: 10.1038/s42255-024-01061-4

Products & Services: Molecular Biology Reagents

GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening

Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner

Journal: ACS Omega

PubMed ID: 38947828

Doi: 10.1021/acsomega.4c01583

Products & Services: Gene Synthesis

Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu

Journal: BMC Plant Biol

PubMed ID: 38851686

Doi: 10.1186/s12870-024-05189-z

Products & Services: PCR Cloning and Subcloning

CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p

Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie

Journal: Genesis

PubMed ID: 38764323

Doi: 10.1002/dvg.23599

Products & Services: Mutant Libraries

N-terminal cysteine acetylation and oxidation patterns may define protein stability

Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Journal: Nat Commun

PubMed ID: 38918375

Doi: 10.1038/s41467-024-49489-2

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Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium

Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti

Journal: Int J Biol Macromol

PubMed ID: 38944065

Doi: 10.1016/j.ijbiomac.2024.133449

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A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis

Authors: Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang

Journal: Free Radic Biol Med

PubMed ID: 38945457

Doi: 10.1016/j.freeradbiomed.2024.06.025

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Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis

Authors: Jianwei Liu, Dixing Lin, Jiadong Lu

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 38836662

Doi: 10.14715/cmb/2024.70.6.29

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Characterization of a novel carboxylesterase from Streptomyces lividans TK24 and site-directed mutagenesis for its thermostability

Authors: Jinxin Fang, Lihua An, Jiao Yu, Jinxue Ma, Rongjie Zhou, Baojuan Wang

Journal: J Biosci Bioeng

PubMed ID: 38871580

Doi: 10.1016/j.jbiosc.2024.05.001

Products & Services: Proteins, Expression, Isolation and Analysis

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG antibodies

Authors: Wen-Ting K Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J Carter

Journal: MAbs

PubMed ID: 38845069

Doi: 10.1080/19420862.2024.2362789

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Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

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Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

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Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Proteins, Expression, Isolation and Analysis

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Proteins, Expression, Isolation and Analysis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

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Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

Products & Services: Gene Synthesis

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Proteins, Expression, Isolation and Analysis

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

Products & Services: DNA Sequencing

Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Proteins, Expression, Isolation and Analysis

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

Products & Services: Gene Synthesis

Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming

Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding

Journal: Adv Sci (Weinh)

PubMed ID: 38923275

Doi: 10.1002/advs.202309314

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens

Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun

Journal: Marine Life Science & Technology

Doi: //doi.org/10.1007/s42995-024-00237-x

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis

Authors: Ross M Walker, Minquan Zhang, Robert L Burnap

Journal: Biochim Biophys Acta Bioenerg

PubMed ID: 38906312

Doi: 10.1016/j.bbabio.2024.149149

Products & Services: Mutant Libraries

Recovery kinetics of dual AAV-mediated human otoferlin expression

Authors: Jonathan B Sellon, Kathy S So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C Drummond, Peter G Slade, Ning Pan, Tyler M Gibson, Tian Yang, Joseph C Burns, Adam T Palermo, Lars Becker

Journal: Front Mol Neurosci

PubMed ID: 38952419

Doi: 10.3389/fnmol.2024.1376128

Products & Services: Gene Synthesis

Discovery of procyanidin condensed tannins of (-)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2

Authors: Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Journal: Int J Biol Macromol

PubMed ID: 38866269

Doi: 10.1016/j.ijbiomac.2024.133059

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Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

Authors: Satyajit Mahapatra, Tomoyuki Takahashi

Journal: Elife

PubMed ID: 38829367

Doi: 10.7554/eLife.90497

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Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

Authors: Ju-Fang Chang, Nils Wellhausen, Nils Wolfgang Engel, Jack H Landmann, Caitlin R Hopkins, January Salas-McKee, Adham S Bear, Mehmet Emrah Selli, Sangya Agarwal, Julie Jadlowsky, Gerald P Linette, Saar Gill, Carl H June, Joseph A Fraietta, Nathan Singh

Journal: Cancer Immunol Res

PubMed ID: 38869428

Doi: 10.1158/2326-6066.CIR-24-0251

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Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization

Authors: Benjamin M Janus, Ruixue Wang, Thomas E Cleveland, Matthew C Metcalf, Aaron C Lemmer, Nydia van Dyk, Sarah Jeong, Anagh Astavans, Kenneth Class, Thomas R Fuerst, Gilad Ofek

Journal: J Virol

PubMed ID: 38832790

Doi: 10.1128/jvi.00155-24

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One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

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The BEL1-like homeodomain protein OsBLH4 regulates rice plant height, grain number, and heading date by repressing the expression of OsGA2ox1

Authors: Chengjuan Cao, Shuaiqiang Guo, Ping Deng, Shiyi Yang, Jing Xu, Tengfei Hu, Zhijuan Hu, Di Chen, Hongsheng Zhang, Ian Paul Navea, Joong Hyoun Chin, Wenhua Zhang, Wen Jing

Journal: Plant J

PubMed ID: 38824648

Doi: 10.1111/tpj.16857

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Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

Authors: Salinthip Jarusintanakorn, Enrico Mastrobattista, Montarop Yamabhai

Journal: N Biotechnol

PubMed ID: 38945523

Doi: 10.1016/j.nbt.2024.06.006

Products & Services: Recombinant Proteins

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

Products & Services: Proteins, Expression, Isolation and Analysis

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