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Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation

Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu

Journal: J Virol

PubMed ID: 38869285

Doi: 10.1128/jvi.00561-24

Products & Services: Proteins, Expression, Isolation and Analysis

Boosting PRRSV-Specific Cellular Immunity: The Immunological Profiling of an Fc-Fused Multi-CTL Epitope Vaccine in Mice

Authors: Xinnuo Lei, Jinzhao Ban, Zhi Wu, Shinuo Cao, Mo Zhou, Li Zhang, Rui Zhu, Huipeng Lu, Shanyuan Zhu

Journal: Vet Sci

PubMed ID: 38922021

Doi: 10.3390/vetsci11060274

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

Products & Services: Molecular Biology Reagents

DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

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Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Authors: Shin-Ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko

Journal: Commun Biol

PubMed ID: 38834758

Doi: 10.1038/s42003-024-06297-0

Products & Services: Proteins, Expression, Isolation and Analysis

Capturing totipotency in human cells through spliceosomal repression

Authors: Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, Peng Du

Journal: Cell

PubMed ID: 38843832

Doi: 10.1016/j.cell.2024.05.010

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Molecular Mechanism of GmSNE3 Ubiquitin Ligase-Mediated Inhibition of Soybean Nodulation by Halosulfuron Methyl

Authors: Yuanfu Li, Jingsi Qiu, Jingxia Yang, Yihan Li, Hui Zhang, Feng Zhao, Huihua Tan

Journal: J Agric Food Chem

PubMed ID: 38867659

Doi: 10.1021/acs.jafc.4c02621

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Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography

Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu

Journal: J Chromatogr A

PubMed ID: 38905946

Doi: 10.1016/j.chroma.2024.465107

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Identification of two novel B cell epitopes on E184L protein of African swine fever virus using monoclonal antibodies

Authors: Weldu Tesfagaber, Desong Lan, Wan Wang, Rui Zhao, Li Yin, Mingyang Yang, Yuanmao Zhu, Encheng Sun, Renqiang Liu, Wenjun Lin, Zhigao Bu, Fang Li, Dongming Zhao

Journal: Virus Res

PubMed ID: 38838820

Doi: 10.1016/j.virusres.2024.199412

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Self-assembled protein vesicles as vaccine delivery platform to enhance antigen-specific immune responses

Authors: Yirui Li, Mariela R Rodriguez-Otero, Julie A Champion

Journal: Biomaterials

PubMed ID: 38879893

Doi: 10.1016/j.biomaterials.2024.122666

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Expanding the genetic toolbox for the obligate human pathogen

Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier

Journal: Front Bioeng Biotechnol

PubMed ID: 38911550

Doi: 10.3389/fbioe.2024.1395659

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Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases

Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth

Journal: Pancreatology

PubMed ID: 38876922

Doi: 10.1016/j.pan.2024.06.003

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GhMPK9-GhRAF39_1-GhWRKY40a Regulates the GhERF1b- and GhABF2-Mediated Pathways to Increase Cotton Disease Resistance

Authors: Xinyue Mi, Weixi Li, Chuan Chen, Huijuan Xu, Guilin Wang, Xuanxiang Jin, Dayong Zhang, Wangzhen Guo

Journal: Adv Sci (Weinh)

PubMed ID: 38845189

Doi: 10.1002/advs.202404400

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A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

Authors: Xiaoqing Guan, Abhishek K Verma, Gang Wang, Abhijeet Roy, Stanley Perlman, Lanying Du

Journal: Vaccines (Basel)

PubMed ID: 38932334

Doi: 10.3390/vaccines12060605

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A novel xylanase from a myxobacterium triggers a plant immune response in Nicotiana benthamiana

Authors: Yuqiang Zhao, Kun Yang, Yanxin Wang, Xu Li, Chengyao Xia, Yan Huang, Zhoukun Li, Cancan Zhu, Zhongli Cui, Xianfeng Ye

Journal: Mol Plant Pathol

PubMed ID: 38924248

Doi: 10.1111/mpp.13488

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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem

Journal: biorxiv

PubMed ID: 38948822

Doi: 10.1101/2024.06.18.599616

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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan

Journal: Stem Cell Res Ther

PubMed ID: 38926849

Doi: 10.1186/s13287-024-03792-3

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A self-healing multispectral transparent adhesive peptide glass

Authors: Gal Finkelstein-Zuta, Zohar A Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit

Journal: Nature

PubMed ID: 38867128

Doi: 10.1038/s41586-024-07408-x

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CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy

Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian

Journal: Blood Adv

PubMed ID: 38564778

Doi: 10.1182/bloodadvances.2023012202

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Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland

Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen

Journal: Microb Biotechnol

PubMed ID: 38829370

Doi: 10.1111/1751-7915.14466

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Comparative Analysis of Orthosteric and Allosteric GLP-1R Agonists' Effects on Insulin Secretion from Healthy, Diabetic, and Recovered INS-1E Pancreatic Beta Cells

Authors: Joshua Reed, Victoria Higginbotham, Stephen Bain, Venkateswarlu Kanamarlapudi

Journal: Int J Mol Sci

PubMed ID: 38928038

Doi: 10.3390/ijms25126331

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A quadrivalent recombinant influenza Hemagglutinin vaccine induced strong protective immune responses in animal models

Authors: Jin Feng, Yingying Du, Liyun Chen, Wenhan Su, Hailiu Wei, Aijiao Liu, Xiaojun Jiang, Jianmin Guo, Cailing Dai, Yuhua Xu, Tao Peng

Journal: Vaccine

PubMed ID: 38834431

Doi: 10.1016/j.vaccine.2024.05.056

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Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex

Authors: Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang & Zengqin Deng

Journal: Cell Research

PubMed ID: 38834762

Doi: 10.1038/s41422-024-00981-w

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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

Authors: Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Freour, Louis Chauviere, Carla Piqueras, Ruben Boers, Joachim Boers, Joost Gribnau, Laurent David, Jean-François Ouimette & Claire Rougeulle

Journal: Nat Struct Mol Biol

PubMed ID: 38834912

Doi: 10.1038/s41594-024-01325-3

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Characterization and regulation of cell cycle-independent noncanonical gene targeting

Authors: Shinta Saito & Noritaka Adachi

Journal: Nature Communications

PubMed ID: 38890315

Doi: 10.1038/s41467-024-49385-9.

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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis

Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan

Journal: Biochem Biophys Res Commun .

PubMed ID: 38626621

Doi: 10.1016/j.bbrc.2024.149934

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Next-generation nanovaccine induces durable immunity and protects against SARS-CoV-2

Authors: Kathleen A Ross, Sean Kelly, Kruttika S Phadke, Nathan Peroutka-Bigus, Olufemi Fasina, Alaric Siddoway, Surya K Mallapragada, Michael J Wannemuehler, Bryan H Bellaire, Balaji Narasimhan

Journal: Acta Biomater

PubMed ID: 38844193

Doi: 10.1016/j.actbio.2024.05.048

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Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma

Journal: Clinics (Sao Paulo)

PubMed ID: 38901133

Doi: 10.1016/j.clinsp.2024.100410

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Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics

Authors: Eun Jung Sohn, Kun-Taek Park

Journal: Neuroreport

PubMed ID: 38935077

Doi: 10.1097/WNR.0000000000002066

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High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling

Authors: Jayati Gera, Dheeraj Kumar, Gunjan Chauhan, Adarsh Choudhary, Lavi Rani, Lolitika Mandal, Sudip Mandal

Journal: J Cell Biol

PubMed ID: 38916917

Doi: 10.1083/jcb.202306087

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Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells

Authors: Tania G Heredia-Torres, Veronica Alvarado-Martínez, Ana R Rincon-Sanchez, Sonia A Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Ana M Rivas-Estilla

Journal: Ann Hepatol

PubMed ID: 38852781

Doi: 10.1016/j.aohep.2024.101517

Products & Services: Molecular Biology Reagents

Sequence and structure analyses of lytic polysaccharide monooxygenases mined from metagenomic DNA of humus samples around white-rot fungi in Cuc Phuong tropical forest, Vietnam

Authors: Nam-Hai Truong, Thi-Thu-Hong Le, Hong-Duong Nguyen, Hong-Thanh Nguyen, Trong-Khoa Dao, Thi-Minh-Nguyet Tran, Huyen-Linh Tran, Dinh-Trong Nguyen, Thi-Quy Nguyen, Thi-Hong-Thao Phan, Thi-Huyen Do, Ngoc-Han Phan, Thi-Cam-Nhung Ngo, Van-Van Vu

Journal: PeerJ

PubMed ID: 38938609

Doi: 10.7717/peerj.17553

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nCas9 Engineering for Improved Target Interaction Presents an Effective Strategy to Enhance Base Editing

Authors: Guiquan Zhang, Ziguo Song, Shisheng Huang, Yafeng Wang, Jiayuan Sun, Lu Qiao, Guanglei Li, Yuanyuan Feng, Wei Han, Jin Tang, Yulin Chen, Xingxu Huang, Furui Liu, Xiaolong Wang, Jianghuai Liu

Journal: Adv Sci (Weinh)

PubMed ID: 38881503

Doi: 10.1002/advs.202405426

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Improvement of TaC9-ABE mediated correction of human SMN2 gene

Authors: Xiaohua Peng, Yue Chi, Jinling Wang, Shuangpeng Li, Yang Liu, Chengcheng Tang, Xiaoqing Zhou, Xuan Lu, Yue Gao, Liangxue Lai, Min Chen, Qingjian Zou

Journal: Biotechnol Bioeng

PubMed ID: 38923503

Doi: 10.1002/bit.28780

Products & Services: GenCrispr Cas9 Genome Editing

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor

Authors: Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H Eric Xu, Jia Duan

Journal: Cell Rep

PubMed ID: 38935498

Doi: 10.1016/j.celrep.2024.114389

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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly

Journal: Structure

PubMed ID: 38870939

Doi: 10.1016/j.str.2024.05.011

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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

Journal: PLoS Pathog

PubMed ID: 38829892

Doi: 10.1371/journal.ppat.1012289

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The role of shear forces in primary and secondary nucleation of amyloid fibrils

Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38875148

Doi: 10.1073/pnas.2322572121

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Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu

Journal: Pharmaceutics

PubMed ID: 38931944

Doi: 10.3390/pharmaceutics16060824

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The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis

Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem

Journal: G3 (Bethesda)

PubMed ID: 38839055

Doi: 10.1093/g3journal/jkae122

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The annotation of has been concealed by its protein-coding pseudogene

Authors: Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten

Journal: Sci Adv

PubMed ID: 38924406

Doi: 10.1126/sciadv.adk1296

Products & Services: Proteins, Expression, Isolation and Analysis

Arabidopsis pollen prolyl-hydroxylases P4H4/6 are relevant for correct hydroxylation and secretion of LRX11 in pollen tubes

Authors: Ana R Sede, Diego L Wengier, Cecilia Borassi, Martiniano Ricardi, Sofía C Somoza, Rafael Aguiló, José M Estevez, Jorge P Muschietti

Journal: J Exp Bot

PubMed ID: 38877792

Doi: 10.1093/jxb/erae269

Products & Services: Proteins, Expression, Isolation and Analysis

Ancient nitrogenases are ATP dependent

Authors: Derek F Harris, Holly R Rucker, Amanda K Garcia, Zhi-Yong Yang, Scott D Chang, Hannah Feinsilber, Betül Kaçar, Lance C Seefeldt

Journal: MBio

PubMed ID: 38869277

Doi: 10.1128/mbio.01271-24

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MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling

Authors: Yan Cai, Yi Zhang, Sihan Wang, E Changyong

Journal: Mol Immunol

PubMed ID: 38901181

Doi: 10.1016/j.molimm.2024.06.002

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PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2

Authors: Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito

Journal: Sci Rep

PubMed ID: 38844490

Doi: 10.1038/s41598-024-63239-w

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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns

Authors: Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco

Journal: RNA

PubMed ID: 38575347

Doi: 10.1261/rna.079933.123

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of Monovalent Direct Degraders of BRD4 That Act Via the Recruitment of DCAF11

Authors: Gregory S Parker, Julia I Toth, Sarah Fish, Gabrielle A Blanco, Taylor Kampert, Xiaoming Li, Linette Yang, Craig R Stumpf, Kenneth Steadman, Aleksandar Jamborcic, Stephen Chien, Elizabeth Daniele, Alejandro Dearie, Geoffray Leriche, Simon Bailey, Peggy A Thompson

Journal: Mol Cancer Ther

PubMed ID: 38907538

Doi: 10.1158/1535-7163.MCT-24-0219

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular Mechanism of WWOX Inhibiting the Development of Esophageal Cancer by Inhibiting Hippo Signaling Pathway

Authors: Zihan Chen, Jingyu Sun, Lili Zhang, Yanglin Sun, Qingqing Ni, Hongkun Zhu, Miao Hui, Longzhen Zhang, Qiang Wang

Journal: Biochem Genet

PubMed ID: 38902482

Doi: 10.1007/s10528-024-10856-9

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Integration of Image Pattern Recognition and Photon Sensor for Analyzing Cytokine Gene Expression Using πCode MicroDisc

Authors: On-Anong Juntit, Kanokporn Sornsuwan, Umpa Yasamut, Chatchai Tayapiwatana

Journal: Biosensors (Basel)

PubMed ID: 38920610

Doi: 10.3390/bios14060306

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T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector

Authors: Ingrid Fert, Laëtitia Douguet, Benjamin Vesin, Fanny Moncoq, Amandine Noirat, Pierre Authié, Sylvain Ciret, Fabien Le Chevalier, Catherine Blanc, Yakov Vitrenko, Pierre Charneau, Laleh Majlessi, François Anna

Journal: npj Vaccines

PubMed ID: 38858404

Doi: 10.1038/s41541-024-00894-0

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Evaluation of transmission-blocking potential of PvPSOP25 using transgenic murine malaria parasite and clinical isolates

Authors: Biying Zhang, Hao Feng, Yan Zhao, Di Zhang, Xinxin Yu, Yusi Li, Ying Zeng, Sataporn Thongpoon, Wanlapa Roobsoong, Yudi Wu, Fei Liu, Jetsumon Sattabongkot, Hui Min, Liwang Cui, Yaming Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 38865344

Doi: 10.1371/journal.pntd.0012231

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Comparison of the performance of SAG2, GRA6, and GRA7 for serological diagnosis of infection in cats

Authors: Serges Sabukunze, Haorong Gu, Lin Zhao, Honglin Jia, Huanping Guo

Journal: Front Vet Sci

PubMed ID: 38898997

Doi: 10.3389/fvets.2024.1423581

Products & Services: Proteins, Expression, Isolation and Analysis

Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesion Ability

Authors: Yuanxing Shi, Yun Xu, Longyu Zhang, Yunjun Yan, Jinyong Yan

Journal: ACS Appl Bio Mater

PubMed ID: 38926913

Doi: 10.1021/acsabm.4c00455

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Liver-specific DICER1 syndrome model mice develop cystic liver tumors with defective primary cilia

Authors: Keiki Oikawa, Shin-Ichiro Ohno, Kana Ono, Kaito Hirao, Ayano Murakami, Yuichirou Harada, Katsuyoshi Kumagai, Katsuko Sudo, Masakatsu Takanashi, Akio Ishikawa, Shouichirou Mineo, Koji Fujita, Tomohiro Umezu, Noriko Watanabe, Yoshiki Murakami, Shinichiro Ogawa, Kris Ann Schultz, Masahiko Kuroda

Journal: J Pathol

PubMed ID: 38922876

Doi: 10.1002/path.6320

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Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients

Authors: Truong Nguyen Duy, Hoang Le Huy, Quyen Đao Thanh, Hoai Ngo Thi, Hanh Ngo Thi Minh, Manh Nguyen Dang, Song Le Huu, Trung Ngo Tat

Journal: Anaerobe

PubMed ID: 38942229

Doi: 10.1016/j.anaerobe.2024.102880

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Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences

Authors: Michal Chappleboim, Segev Naveh-Tassa, Miri Carmi, Yaakov Levy, Naama Barkai

Journal: Nucleic Acids Res

PubMed ID: 38597680

Doi: 10.1093/nar/gkae249

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A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy

Authors: Zhiyong Shi , Miaomiao Liu , Xiaowen Zhang , Jingyang Wang , Junwei Zhang , Zeyan Peng , Li Meng , Ruijing Wang ,Yang Xu , Jie Yan , Jianlin Cui , Shan Ren , Yang Gao , Yanming Wang , Zhi Qi

Journal: Theranostics

PubMed ID: 38948069

Doi: 10.7150/thno.92119

Products & Services: Nucleic Acid Purification & Analysis

An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria

Authors: Linfu Chen a, Zheyu Kang a, Jingjing Shen a, Rui Zhao a, Yu Miao a, Lin Zhang b, Zixuan Zheng c, Zhemin Zhang c, Nanhui Liu a, Cheng Wang a, Huapan Fang a, Jun Zhou a, Yudong Wang b, Zhuang Liu a, Yang Yang c, Qian Chen

Journal: Science Bulletin

Doi: doi.org/10.1016/j.scib.2024.06.016

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Highly biased agonism for GPCR ligands via nanobody tethering

Authors: Shivani Sachdev, Brendan A Creemer, Thomas J Gardella, Ross W Cheloha

Journal: Nat Commun

PubMed ID: 38824166

Doi: 10.1038/s41467-024-49068-5.

Products & Services: Proteins, Expression, Isolation and Analysis PCR Cloning and Subcloning

BRET-based biosensors for SARS-CoV-2 oligonucleotide detection

Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas

Journal: Front Bioeng Biotechnol

PubMed ID: 38887615

Doi: 10.3389/fbioe.2024.1353479

Products & Services: Proteins, Expression, Isolation and Analysis

A growth selection system for sucrose synthases (SuSy): design and test

Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner

Journal: AMB Express

PubMed ID: 38865019

Doi: 10.1186/s13568-024-01727-y

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Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Journal: Nat Commun

PubMed ID: 38890271

Doi: 10.1038/s41467-024-49041-2

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Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma

Journal: Microb Cell Fact

PubMed ID: 38879464

Doi: 10.1186/s12934-024-02453-7

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Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda

Journal: J Biol Chem

PubMed ID: 38879015

Doi: 10.1016/j.jbc.2024.107464

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Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine β-globin polymorphism

Authors: Cintia Hiromi Okino, Simone Cristina Méo Niciura, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Gláucia Roberta Melito, Hélio José Montassier, Ana Carolina de Souza Chagas

Journal: Dev Comp Immunol

PubMed ID: 38901502

Doi: 10.1016/j.dci.2024.105216

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SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Journal: Vaccines (Basel)

PubMed ID: 38932392

Doi: 10.3390/vaccines12060663

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Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse

Authors: Aoxiang Wang, Jinxi Zhou, Yiwen Hong, Yamei Cui, Yishen Wang, Jianying Pan, Yue Wu, Yan Luo

Journal: Ophthalmic Res

PubMed ID: 38857592

Doi: 10.1159/000539605

Products & Services: Proteins, Expression, Isolation and Analysis

Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice NF-κb-signaling pathway

Authors: Tao-Lin Qing, Xuan-Yao Jiang, Jin-Feng Li, Qi Shen, Xin-Yi Zhao, Li-Jun Ren, Xiao-Yu Dai, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Bin Zhang, Lang Yan, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Inhal Toxicol

PubMed ID: 38836332

Doi: 10.1080/08958378.2024.2351098

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Yeast Expressing a Phage Endolysin Reduces Endogenous in 21-Day-Old Broiler Chicken Intestinal Fluids

Authors: Michael R Barnas, Wendy D Attuquayefio, David M Donovan, Christopher D Skory, Rosemarie W Hammond, Gregory R Siragusa, Jennifer R Timmons

Journal: Avian Dis

PubMed ID: 38885054

Doi: 10.1637/aviandiseases-D-23-00088

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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity

Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee

Journal: J Allergy Clin Immunol

PubMed ID: 38878020

Doi: 10.1016/j.jaci.2024.03.029

Products & Services: Proteins, Expression, Isolation and Analysis

Dietary intake of a MFGM/EV-rich concentrate promotes accretion of very long odd-chain sphingolipids and increases lipid metabolic turnover at the whole-body level

Authors: Richard R Sprenger, Mesut Bilgin, Marie S Ostenfeld, Ann Bjørnshave, Jan T Rasmussen, Christer S Ejsing

Journal: Food Res Int

PubMed ID: 38945615

Doi: 10.1016/j.foodres.2024.114601

Products & Services: Proteins, Expression, Isolation and Analysis

Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles

Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei

Journal: Macromol Rapid Commun

PubMed ID: 38923127

Doi: 10.1002/marc.202400173

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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning

Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos

Journal: Tumour Virus Res

PubMed ID: 38909779

Doi: 10.1016/j.tvr.2024.200287

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses

Authors: Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan

Journal: J Virol

PubMed ID: 38829138

Doi: 10.1128/jvi.00769-24

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Mapping the structural landscape of the yeast Ty3 retrotransposon RNA genome

Authors: Angelika Andrzejewska-Romanowska, Julita Gumna, Ewa Tykwińska, Katarzyna Pachulska-Wieczorek

Journal: Nucleic Acids Res

PubMed ID: 38864374

Doi: 10.1093/nar/gkae494

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside

Authors: Yating Liu, Xiaoyang Han, Mengya Zhao, Lan Liu, Zixin Deng, Qiu Zhao, Yi Yu

Journal: PLANT JOURNAL

PubMed ID: 38872484

Doi: 10.1111/tpj.16807

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Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot Nematode

Authors: Chenmi Mo, Lei Zhang

Journal: Int J Mol Sci

PubMed ID: 38928010

Doi: 10.3390/ijms25126300

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Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission

Authors: Ellen A Kearney, Punam Amratia, Su Yun Kang, Paul A Agius, Kefyalew Addis Alene, Katherine O'Flaherty, Win Han Oo, Julia C Cutts, Win Htike, Daniela Da Silva Goncalves, Zahra Razook, Alyssa E Barry, Damien Drew, Aung Thi, Kyaw Zayar Aung, Htin Kyaw Thu, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, James G Beeson, Julie A Simpson, Peter W Gething, Ewan Cameron, Freya J I Fowkes

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38833464

Doi: 10.1073/pnas.2320898121

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Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles

Authors: Leticia Guzman Ruiz, Alexander M Zollner, Irene Hoxie, Elsa Arcalis, Florian Krammer, Miriam Klausberger, Alois Jungbauer, Reingard Grabherr

Journal: Front Immunol

PubMed ID: 38915410

Doi: 10.3389/fimmu.2024.1425842

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Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

Authors: Ignacio Fernández, Nell Saunders, Stéphane Duquerroy, William H Bolland, Atousa Arbabian, Eduard Baquero, Catherine Blanc, Pierre Lafaye, Ahmed Haouz, Julian Buchrieser, Olivier Schwartz, Félix A Rey

Journal: Cell

PubMed ID: 38964326

Doi: 10.1016/j.cell.2024.06.007

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Trichostatin A Promotes Cytotoxicity of Cisplatin, as Evidenced by Enhanced Apoptosis/Cell Death Markers

Authors: Yang Zhou, Qun Luo, Fangang Zeng, Xingkai Liu, Juanjuan Han, Liangzhen Gu, Xiao Tian, Yanyan Zhang, Yao Zhao, Fuyi Wang

Journal: Molecules

PubMed ID: 38893499

Doi: 10.3390/molecules29112623

Products & Services: Proteins, Expression, Isolation and Analysis

The porcine circovirus 3 humoral response: characterization of maternally derived antibodies and dynamic following experimental infection

Authors: Molly Kroeger, Gun Temeeyasen, Steven Dilberger-Lawson, Eric Nelson, Ronaldo Magtoto, Luis Gimenez-Lirola, Pablo Piñeyro

Journal: Microbiol Spectr

PubMed ID: 38916319

Doi: 10.1128/spectrum.00870-24

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High-yield porphyrin production through metabolic engineering and biocatalysis

Authors: Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Liming Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang

Journal: Nat Biotechnol

PubMed ID: 38839873

Doi: 10.1038/s41587-024-02267-3

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Drosophila immune cells transport oxygen through PPO2 protein phase transition

Authors: Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim

Journal: Nature

PubMed ID: 38926577

Doi: 10.1038/s41586-024-07583-x

Products & Services: Proteins, Expression, Isolation and Analysis

Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM

Authors: Rajeswari Basu, Richard Dambra, Di Jiang, Sophia A Schätzlein, Shu Njiyang, Joseph Ashour, Abhilash I Chiramel, Adam Vigil, Vladimir V Papov

Journal: Microbiol Spectr

PubMed ID: 38916347

Doi: 10.1128/spectrum.03651-23

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Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis

Authors: Sergi Torres-Puig, Silvia Crespo-Pomar, Hatice Akarsu, Thatcha Yimthin, Valentina Cippà, Thomas Démoulins, Horst Posthaus, Nicolas Ruggli, Peter Kuhnert, Fabien Labroussaa, Jörg Jores

Journal: Commun Biol

PubMed ID: 38942984

Doi: 10.1038/s42003-024-06497-8

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Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage

Authors: Sarah Stuart, Daniel Tarade, Michael Ohh

Journal: Sci Rep

PubMed ID: 38926538

Doi: 10.1038/s41598-024-65537-9

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Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Authors: Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Dustin S Siegel, Jason K Perry, Joy Y Feng, John P Bilello, Matthias Götte

Journal: J Biol Chem

PubMed ID: 38945449

Doi: 10.1016/j.jbc.2024.107514

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Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen

Authors: Ann Fernando, Amanda Sparkes, Esther I Matus, Ayushi Patel, F Stuart Foster, David Goertz, Peter Lee, Jean Gariépy

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38898951

Doi: 10.1021/acsptsci.4c00140

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Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

Authors: Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun, Yuliang Zhang, Sean F Gilmore, Megan Shelby, Feliza Bourguet, Mariam Mohagheghi, Aleksandr Noy, Amy Rasley, Luis M de la Maza, Matthew A Coleman

Journal: biorxiv

PubMed ID: 38895407

Doi: 10.1101/2024.06.04.597210

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Deciphering Structural Traits for Thermal and Kinetic Stability Across Protein Family Evolution through Ancestral Sequence Reconstruction

Authors: Pablo A Cea, Myriam Pérez, Sixto M Herrera, Sebastián M Muñoz, Nicolás Fuentes-Ugarte, José Coche-Miranda, Pablo Maturana, Victoria Guixé, Victor Castro-Fernandez

Journal: Mol Biol Evol

PubMed ID: 38913681

Doi: 10.1093/molbev/msae127

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Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Expression Correlates With a Metastatic-like Phenotype in Epidermoid Carcinoma, Pediatric Medulloblastoma, and Mesothelioma

Authors: Jorge Marquez, Jianping Dong, Jun Hayashi, Ginette Serrero

Journal: J Cell Biochem

PubMed ID: 38924562

Doi: 10.1002/jcb.30616

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Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Authors: Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang