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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

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Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

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Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

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Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

Products & Services: Proteins, Expression, Isolation and Analysis

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

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Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module

Authors: Jiaojiao Zhang, Jiayi Xu, Xinman Wang, Ying Liu, Shuangtao Li, Jialong Zhang, Lingfeng He, Luqin Guo, Chonghua Li, Xin-Xu Li, Yang-Dong Guo, Na Zhang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39847324

Doi: 10.1073/pnas.2404445122

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An Insect Eﬀector Mimics Its Host Immune Regulator to Undermine Plant Immunity

Authors: Jianmei Fu , Shuai Li , Jing Li , Zhichang Zhao , Jing Li , Xinyang Tan , Shan Yu , Maofeng Jing , Keyan Zhu-Salzman , Jichao Fang , Rui Ji

Journal: Adv Sci (Weinh)

PubMed ID: 39853648

Doi: doi.org/10.1002/advs.202409186

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Direct repeat region 3’ end modifications regulate Cas12a activity and expand its applications

Authors: Wei Zhang , Yinyin Zhong , Jiaqi Wang , Guangrong Zou , Qiaozhen Chen , Chaoxing Liu

Journal: Nucleic Acids Res

PubMed ID: 39883010

Doi: 10.1093/nar/gkaf040

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Dictating the spatial-temporal delivery of molecular adjuvant and antigen for the enhanced vaccination

Authors: Yumeng Yan , Xiaonan Huang , Lili Yuan , To Ngai , Guanghui Ma , Yufei Xia

Journal: Biomaterials

PubMed ID: 38968687

Doi: 10.1016/j.biomaterials.2024.122697

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Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1+ Macrophages for Infectious Bone Defect Regeneration

Authors: Hao Wu , Changcheng Chen , Jiangfeng Li , Dongmei Yu , Xun Wu , Hai Huang , Zhen Tang , Qi Wu , Shichao Yan , Ning Wang , Mo Wang , Feilong Wei , Yunlong Yu , Duan Wang , Mengting Shi , Xusong Yue , Pengfei Cao , Zenghui Zheng , Xiaokang Li , Baolin Guo , Lei Shi , Zheng Guo

Journal: ACS Nano

PubMed ID: 39690461

Doi: 10.1021/acsnano.4c13562

Products & Services: Proteins, Expression, Isolation and Analysis

Remotely Sequential Activation of Biofunctional MXenes for Spatiotemporally Controlled Photothermal Cancer Therapy Integrated with Multimodal Imaging

Authors: Jing Jia , Xiaobo Zhang , Yiran Li , Tian Wang , Ying An , Xinrong Yan , Bin Liu , Chaoyi Yang , Huangxian Ju

Journal: Small

PubMed ID: 39665387

Doi: 10.1002/smll.202410535

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High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register

Authors: Qian Zhang, Mingqiang Li, Yuqing Tang, Jinyan Zhang, Chenyun Sun, Yaya Hao, Jianing Cheng, Xiaodong Xie, Sisi Jia, Hui Lv, Fei Wang, and Chunhai Fan

Journal: ACS Central Science

Doi: doi.org/10.1021/acscentsci.4c01557

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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Authors: Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Jinye Xiong, Chunyan Yang, Zhenhua Wu, Xi Huang, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Baoding Zhang, Jin-Wei Feng, Junjie Chen, Yuanji Feng, Huapan Fang, Liyun Lin, Z K Xie, Beibei Sun, Huayu Tian, Yong Yu, Hai-Long Piao, Xiao-Song Xie, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin

Journal: Nature

PubMed ID: 39695235

Doi: 10.1038/s41586-024-08348-2

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Exploring bifunctional molecules for anti-SARS-CoV-2 and anti-inflammatory activity through structure-based virtual screening, SAR investigation, and biological evaluation

Authors: Jiani Lu , Yingying He , Yaqi Li , Xixiang Chen , Hongtao Li , Xuwen Chen , Jianrong Xu , Hongzhuan Chen ，Ying Wang , Xiao He , Shunying Liu , Lili Chen

Journal: Int J Biol Macromol

PubMed ID: 39653224

Doi: 10.1016/j.ijbiomac.2024.138529

Products & Services: Peptide Synthesis

Immunoaffinity Intact Top-Down Mass Spectrometry for Quantification of Neuron-Specific Enolase Gamma, a Low-Abundance Protein Biomarker

Authors: Sebastian A H van den Wildenberg , Sylvia A A M Genet , Maarten A C Broeren , Joost L J van Dongen , Maxime C M van den Oetelaar , Luc Brunsveld , Volkher Scharnhorst , Daan van de Kerkhof

Journal: Anal Chem

PubMed ID: 39710932

Doi: 10.1021/acs.analchem.4c04677

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Mechanistic study of SCOOPs recognition by MIK2–BAK1 complex reveals the role of N-glycans in plant ligand–receptor– coreceptor complex formation

Authors: Huimin Wu , Lihao Wan , Zunyong Liu , Yunqing Jian , Chenchen Zhang , Xiakun Mao , Zhiyun Wang , Qiang Wang , Yaxin Hu , Lizhong Xiong , Zhujun Xia , Juan Xue , Shan Li , Ping He , Libo Shan , Shutong Xu

Journal: Nat Plants

PubMed ID: 39511418

Doi: 10.1038/s41477-024-01836-3

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Utilization of Fc-specific peptide to orientally immobilize antibodies markedly improves the analytical performance of lateral flow immunoassay strips for aflatoxin B1

Authors: Jin Li , Xintong Li , Yulian Wang , Qianxu Zhou , Guoqing Shi

Journal: MICROCHEMICAL JOURNAL

Doi: 10.1016/j.microc.2024.112404

Products & Services: Peptide Synthesis

SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis

Authors: Xiao Guo , Shimin Yang , Zeng Cai , Shunhua Zhu , Hongyun Wang , Qianyun Liu , Zhen Zhang , Jiangpeng Feng , Xianying Chen , Yingjian Li , Jikai Deng , Jiejie Liu , Jiali Li , Xue Tan , Zhiying Fu , Ke Xu , Li Zhou , Yu Chen

Journal: J Cell Biol

PubMed ID: 39680116

Doi: 10.1083/jcb.202404131

Products & Services: Proteins, Expression, Isolation and Analysis

Respiratory syncytial virus glycoprotein G impedes CX3CR1-activation by CX3CL1 and monocyte function

Authors: Robert Meineke, Ayse Agac, Marie-Christin Knittler, Martin Ludlow, Albert D. M. E. Osterhaus & Guus F. Rimmelzwaan

Journal: npj viruses

Doi: doi.org/10.1038/s44298-024-00075-9

Products & Services: Gene Synthesis Mutagenesis Services

Combinations of HDAC Inhibitor and PPAR Agonist Induce Ferroptosis of Leukemic Stem Cell-like Cells in Acute Myeloid Leukemia

Authors: Hui Zhou, Dongmei Qin, Chendi Xie, Jie Zhou, Shuman Jia, Ziwei Zhou, Yi Qiu, Bing Xu, Jie Zha

Journal: Clinical cancer research

PubMed ID: 39321217

Doi: 10.1158/1078-0432.CCR-24-0796.

Products & Services: Proteins, Expression, Isolation and Analysis

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction

Authors: Wenzhuo Fang , Ying Wang , Kaile Zhang , Ming Yang , Meng Liu , Yangwang Jin , Xianjie Xiu , Yuhui Wang , Zhenwei Yu , Ranxing Yang , Qiang Fu

Journal: Adv Sci (Weinh)

PubMed ID: 39691071

Doi: 10.1002/advs.202409930

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Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2

Authors: Jiuyin Xu , Youwei Xu , Li Hou , Xinheng He , Yang Li , Jing Zhao , Xue Meng , James Jiqi Wang , Yanli Wu , Heng Zhang , Yunhai Li , Wen Hu , Qingning Yuan , Kai Wu , Xi Cheng , Yi Jiang , Yu Xia , H Eric Xu , Canrong Wu

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 39665758

Doi: 10.1073/pnas.2403304121

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

Authors: Matthew J O'Neill, Chai-Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian Kozek, Loren R Vanags, Devyn W Mitchell, Alex Shen, Yuko Wada, Asami Kashiwa, Lia Crotti, Federica Dagradi, Giulia Musu, Carla Spazzolini, Raquel Neves, J Martijn Bos, John R Giudicessi, Xavier Bledsoe, Eric R Gamazon, Megan C Lancaster, Andrew M Glazer, Bjorn C Knollmann, Dan M Roden, Jochen Weile, Frederick Roth, Joe-Elie Salem, Nikki Earle, Rachael Stiles, Taylor Agee, Christopher N Johnson, Minoru Horie, Jonathan R Skinner, Michael J Ackerman, Peter J Schwartz, Seiko Ohno, Jamie I Vandenberg, Brett M Kroncke

Journal: Circulation

PubMed ID: 39315434

Doi: 10.1161/CIRCULATIONAHA.124.069828

Products & Services: PCR Cloning and Subcloning

An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound-Responsive Bacteria for Colon Cancer Immunotherapy

Authors: Jiexin Li, Ruiqi Yang, Yihang Yuan, He Ren, Chao Fang, Jonathan F Lovell, and Yumiao Zhang

Journal: ADV FUNCT MATER

Doi: 10.1002/adfm.202414994

Products & Services: Peptide Synthesis Recombinant Proteins

SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

Authors: Chun Liu , Kun Wu , Chuwen Li , Zhen Zhang , Peisong Zhai , Haiyan Guo , Jianjun Zhang

Journal: J Exp Clin Cancer Res

PubMed ID: 39726047

Doi: 10.1186/s13046-024-03255-w

Products & Services: Proteins, Expression, Isolation and Analysis

Dual-Targeted Protein MRI Contrast Agent for Early

Authors: Ruofan Hu, Zhiyang Wang, Tinghui Shen, Qianwen Yang, Weizhi Chen, Xiqun Jiang

Journal: Aggregate

Doi: 10.1002/agt2.732

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structure of Nipah virus RNA polymerase complex

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Yuhan Wang, Jiao Tang, Simiao Liu, Huihan Gao, Xiaoxiao Zhang, Luca Zinzula, Roger D Kornberg, Heqiao Zhang

Journal: Science Advances

PubMed ID: 39661676

Doi: 10.1126/sciadv.adr7116

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Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses.

Authors: Tyler M. Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Simon Lord-Dufour, Michael J. McCluskie, Yves Durocher & Bassel Akache

Journal: npj Viruses

Doi: 10.1038/s44298-024-00067-9

Products & Services: Gene Synthesis

Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Authors: Zhengren Xu, Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong

Journal: Angew Chem Int Ed Engl

PubMed ID: 39601390

Doi: 10.1002/anie.202419092

Products & Services: Gene Synthesis

An intracellular bacterial pathogen triggers RIG-I/ MDA5-dependent necroptosis

Authors: Hang Xu , Huili Li , Boguang Sun,, Li Sun

Journal: Current Research in Microbial Sciences

Doi: doi.org/10.1016/j.crmicr.2024.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Tuning the Sensitivity of MoS2 Nanopores: From Labeling to Labeling-Free Detection of DNA Methylation

Authors: Chunxiao Zhao, Yibo Yang, Pinlong Zhao, Chongbin Shi, Tianhui Tan, Hongzhen Bai, Jiandong Feng

Journal: Small Methods

PubMed ID: 39555656

Doi: 10.1002/smtd.202401532

Products & Services: Gene Synthesis Bacterial Expression

Expression and functional study of DNA polymerases from Psychrobacillus sp. BL-248-WT-3 and FJAT-21963

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Microbiol

PubMed ID: 39633807

Doi: doi.org/10.3389/fmicb.2024.1501020

Products & Services: Gene Synthesis

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning“Method for Mechanistic Investigations of Terpene Cyclases

Authors: Shouqi Zhang, Kaibiao Wang,Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan, and Zhengren Xu

Journal: ACS catalysis

Doi: 10.1021/acscatal.4c05811

Products & Services: Gene Synthesis

Bivalent CD47 immunotoxin for targeted therapy of T-cell acute lymphoblastic leukemia

Authors: Jihong Ma , Zhaohui Wang , Danielle Mintzlaff , Huiping Zhang , Rashmi Ramakrishna , Eduardo Davila , Matthew T Witkowski , M Scott Lucia , Marc S Schwartz , Elizabeth A Pomfret , David W Mathes , Zhirui Wang

Journal: Blood

PubMed ID: 39561285

Doi: 10.1182/blood.2024025277

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Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis

Authors: Ren-Yi Su, Chen-Hao Xu, Hai-Jun Guo, Li-Jun Meng, Jian-Yong Zhuo, Nan Xu, Hui-Gang Li, Chi-Yu He, Xuan-Yu Zhang, Zheng-Xin Lian, Shuai Wang, Chenhao Cao, Ruhong Zhou, Di Lu, Shu-Sen Zheng, Xu-Yong Wei, Xiao Xu

Journal: J Adv Res

PubMed ID: 39547439

Doi: 10.1016/j.jare.2024.11.021

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

Authors: Deyu Zhang , Bo Li , Henan Xu , Jingying Li , Chao Ma , Wei Ge , Congcong Lu , and Xuetao Cao

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39570315

Doi: 10.1073/pnas.2406961121

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Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

Authors: Qimeng Liu , Tianliang Ma , Zheyu Zhang , Jiangyu Nan , Guanzhi Liu , Yute Yang , Yihe Hu , Jie Xie

Journal: J Extracell Vesicles

PubMed ID: 39711510

Doi: 10.1002/jev2.70028

Products & Services: Proteins, Expression, Isolation and Analysis

Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies

Authors: Shuhong Li , Licai Shi , Lijun Zhao , Qiaoru Guo , Jun Li , Ze-Lin Liu , Zhi Guo , Yu J Cao

Journal: Nat Commun

PubMed ID: 39528513

Doi: 10.1038/s41467-024-54150-z

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The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Authors: Guohao Wang , Shixiao Peng , Miriam Reyes Mendez , Angelo Keramidas , David Castellano , Kunwei Wu , Wenyan Han , Qingjun Tian , Lijin Dong , Yan Li , Wei Lu

Journal: Cell

PubMed ID: 39357522

Doi: 10.1016/j.cell.2024.09.006

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Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction

Authors: Xin-Xin Zhu, Wen-Qing Zheng, Zi-Wei Xia, Xin-Ru Chen, Tian Jin, Xu-Wei Ding, Fei-Fei Chen, Qi Chen, Jian-He Xu, Xu-Dong Kong, Gao-Wei Zheng

Journal: Nat Commun

PubMed ID: 39609402

Doi: 10.1038/s41467-024-54613-3

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Interactions established by isoform-specific TrkB-T1 sequences govern inflammatory response and neurotoxicity in stroke

Authors: Lola Ugalde-Triviño, Gonzalo S. Tejeda, Gema M. Esteban-Ortega, Margarita Díaz-Guerra

Journal: bioRxiv

Doi: doi.org/10.1101/2024.11.13.623346

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Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein

Authors: Yingcai Xiong , Keyu Tao , Tao Li , Yinghui Zhou , Zhaowei Zhang , Weiying Ou , Zhao Wang , Shouchuan Wang , Yayi Hou , Peng Cao , Jianjian Ji

Journal: J Virol

PubMed ID: 39508604

Doi: 10.1128/jvi.01536-24

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Engineered mRNAs with stable structures minimize double-stranded RNA formation and increase protein expression

Authors: Qianshan Qin , Huayuan Yan , Weixiang Gao , Ruyin Cao , Guopeng Liu , Xiaojing Zhang , Niangang Wang , Wenjie Zuo , Lei Yuan , Peng Gao , Qi Liu

Journal: J Mol Biol

PubMed ID: 39427983

Doi: 10.1016/J.JMB.2024.168822

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Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

Authors: Jing Wang , Zhengyang An , Zhongsheng Wu , Wei Zhou , Pengyu Sun , Piyu Wu , Song Dang , Rui Xue , Xue Bai , Yongtao Du , Rongmei Chen , Wenxu Wang , Pei Huang , Sin Man Lam , Youwei Ai , Suling Liu , Guanghou Shui , Zhe Zhang , Zheng Liu , Jianyong Huang , Xiaohong Fang , Kangmin He

Journal: Mol Cell

PubMed ID: 39488211

Doi: 10.1016/j.molcel.2024.10.010

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RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA

Authors: Liying Zhang, Zhiheng Deng, Yunxiang Du, Ziyu Xu, Tianyi Zhang, Zebin Tong, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Bioorg Med Chem

PubMed ID: 39580855

Doi: 10.1016/j.bmc.2024.118016

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

A high-performance protein preparation approach in a single column-free step

Authors: Yuan Huang, Yuanyuan Zhang, Xiaofeng Yang, Zhanglin Lin

Journal: Trends Biotechnol

PubMed ID: 39537535

Doi: 10.1016/j.tibtech.2024.10.008

Products & Services: Proteins, Expression, Isolation and Analysis

Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy

Authors: Youdong Chen 1, Yujie Lu , Huali Lei 1, Lin Liu , Xianmin Li 1, Yuqi Yang 1, Shumin Sun 1, Qiao Yu 1, Li Wang 1, Jie Wu 1 2, Jingrui Li 1, Guanghui Hou 1, Liang Cheng

Journal: ACS Nano

PubMed ID: 39404652

Doi: 10.1021/acsnano.4c10378

Products & Services: Proteins, Expression, Isolation and Analysis

Self-Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor-Draining Lymph Nodes to Enhance Cancer Immunotherapy

Authors: Xiuhua Pan, Feiyang Liu, Ruixin Kang, Zongwei Hu, Yueru Pang, Ziqi Shen, Xiawei Zhou, Jun Zhang, Qi Shen

Journal: ADVANCED FUNCTIONAL MATERIALS

Doi: 10.1002/adfm.202409736

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SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains

Authors: Yuewen Han 1, Haiwu Zhou 1, Cong Liu 1, Weiwei Wang 1, Yali Qin 2, Mingzhou Chen

Journal: Journal of Virology

PubMed ID: 39412257

Doi: 10.1128/jvi.01036-24

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Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Containing Cyclic Guanosine Monophosphate-Adenosine Monophosphate Eliminate Established Tumors

Authors: Jinchao Yu , Xinyan Li , Junyao Li , Nan Sun , Peng Cheng , Jiayi Huang , Sai Li , Rui Kuai

Journal: ACS Nano

PubMed ID: 39418110

Doi: 10.1021/acsnano.4c10673

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Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

Authors: Yingwei Ge , Lijie Zhou, Yesheng Fu , Lijuan He, Yi Chen , Dingchang Li , Yuping Xie , Jun Yang , Haitao Wu, Hongmiao Dai , Zhiqiang Peng , Yong Zhang , Shaoqiong Yi , Bo Wu 1, Xin Zhang, Yangjun Zhang , Wantao Ying 1, Chun-Ping Cui , Cui Hua Liu , Lingqiang Zhang

Journal: Nature Cell Biology

PubMed ID: 39482354

Doi: 10.1038/s41556-024-01522-8

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Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

Authors: Xing-Yue He , Meng-Meng Han , Yu-Chen Zhao , Ling Tang , Yi Wang , Lei Xing , Ning Wei , Jing Wang , Guang-Ji Wang , Fang Zhou, Jee-Heon Jeong, Hu-Lin Jiang

Journal: Journal of controlled release

PubMed ID: 39476873

Doi: 10.1016/j.jconrel.2024.10.056

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Online detecting living cells released TNF-α and studying intercellular communication using SuperDNA self-assembled conical nanochannel

Authors: Weiwei Liu , Yu Liu , Zhaoyan Tian , Zhaohan Wang , Hui Liu , Songqin Liu , Yafeng Wu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2024.110561

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The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Authors: Yongjing Shi , Xiaodong Zheng , Hui Peng , Chenqi Xu , Rui Sun , Zhigang Tian , Haoyu Sun , Xianwei Wang

Journal: Cancer Immunol Res

PubMed ID: 38990095

Doi: 10.1158/2326-6066.CIR-23-1061

Products & Services: Proteins, Expression, Isolation and Analysis

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

Authors: Hongyi Zhou , Vijay Patel , Robert Rice , Richard Lee , Ha Won Kim , Neal L Weintraub , Huabo Su , Weiqin Chen

Journal: Cells

PubMed ID: 39404417

Doi: 10.3390/cells13191654

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Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Authors: Yoshita Srivastava , Olayinka Akinyemi , Tiana C Rohe , Elizabeth M Pritchett , Cameron D Baker , Akshara Sharma , Jermaine L Jenkins , David H Mathews , Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 39413212

Doi: 10.1093/nar/gkae886

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Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy

Authors: Xiao-Kang Jin , Shun-Kang Zhang , Shi-Man Zhang , Jun-Long Liang , Xiao Yan , Yan-Tong Lin , Ran Meng , Zi-Han Xu , Chuan-Jun Liu , Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 39468892

Doi: 10.1002/adma.202410957

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5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response

Authors: Hanyong Jin , Ji-Hyun Yeom , Eunkyoung Shin , Yoonjie Ha , Haifeng Liu , Daeyoung Kim , Minju Joo , Yong-Hak Kim , Hak Kyun Kim , Minkyung Ryu, Hong-Man Kim , Jeongkyu Kim , Keun P Kim , Yoonsoo Hahn , Jeehyeon Bae , Kangseok Lee

Journal: Nature Communications

PubMed ID: 39468069

Doi: 10.1038/s41467-024-53624-4

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The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

Authors: Jing-Jing Tu , Yan-Yu Zang , Yun Stone Shi ,and Xiao-Yu Teng

Journal: cells

Doi: doi.org/10.3390/cells13211784

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Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity

Authors: Jingru Wang , Man Liu , Jingwen Wang , Zhuoyue Li , Zhenhan Feng , Meiqi Xu , Hui Wang , Hui Li , Zhantao Li , Jianming Yu , Junwei Liu , Qingchao Wei , Shuang Zhang , Xuan Zhang

Journal: Acta Pharm Sin B

PubMed ID: 39525585

Doi: 10.1016/j.apsb.2024.07.002

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Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation

Authors: Amrita Khakurel , Irina Pokrovskaya , Vladimir V Lupashin

Journal: traffic

PubMed ID: 39416116

Doi: 10.1111/tra.70003

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A novel strategy of co-expressing CXCR5 and IL-7 enhances CAR-T cell effectiveness in osteosarcoma

Authors: Xinhui Hui1†Muhammad Asad Farooq,&#x;Muhammad Asad Farooq1,2†Yiran ChenYiran Chen1Iqra Ajmal,Iqra Ajmal1,2Yaojun Ren,Yaojun Ren1,3Min XueMin Xue1Yuzhou JiYuzhou Ji1Bingtan DuBingtan Du1Shijia WuShijia Wu1Wenzheng Jiang*&#x;Wenzheng Jiang1*‡

Journal: Frontiers in Immunology

Doi: doi.org/10.3389/fimmu.2024.1462076

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AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Authors: Zhen Wang , Xiaofan Zhang , Chunyan Liu , Susan Duncan , Runlai Hang , Jing Sun , Lilan Luo , Yiliang Ding , Xiaofeng Cao

Journal: Nature Communications

PubMed ID: 39375381

Doi: 10.1038/s41467-024-52945-8

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Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Authors: Jialin Chen , Renwang Sheng , Qingyun Mo , Ludvig J Backman , Zhiyuan Lu , Qiuzi Long , Zhixuan Chen , Zhicheng Cao , Yanan Zhang , Chuanquan Liu , Haotian Zheng , Yu Qi , Mumin Cao , Yunfeng Rui , Wei Zhang

Journal: Bioact Mater

PubMed ID: 39512422

Doi: 10.1016/j.bioactmat.2024.10.016

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Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

Authors: Lele Tao , Dongxue Wang , Qingning Yuan Fenghui Zhao , Yu Zhang , Tianyuan Du , Shiyi Shen , H Eric Xu , Yi Li , Dehua Yang , Jia Duan

Journal: Cell Research

PubMed ID: 38969802

Doi: 10.1038/s41422-024-00995-4

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Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection

Authors: Gema María Esteban-Ortega, Margarita Díaz-Guerra

Journal: bioRxiv

Doi: doi.org/10.1101/2024.10.29.620835

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Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans

Authors: Yabin Hu, Qian Wu, Fangfang Chang, Jing Yang, Xiaoyue Zhang, Qijie Wang, Jun Chen, Shishan Teng, Yongchen Liu, Xingyu Zheng, You Wang, Rui Lu, Dong Pan, Zhanpeng Liu, Fen Liu, Tianyi Xie, Chanfeng Wu, Yinggen Tang, Fei Tang, Jun Qian, Hongying Chen, Wenpei Liu, Yi-Ping Li, Xiaowang Qu

Journal: NPJ Vaccines

PubMed ID: 39438493

Doi: 10.1038/s41541-024-00997-8

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Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

Authors: Huasong Ai , Zebin Tong , Zhiheng Deng , Qiang Shi, Shixian Tao , Gaoge Sun, Jiawei Liang , Maoshen Sun , Xiangwei Wu , Qingyun Zheng , Lujun Liang , Hang Yin , Jia-Bin Li , Shuai Gao , Changlin Tian , Lei Liu , Man Pan

Journal: Nature Chemical Biology

PubMed ID: 39394267

Doi: doi.org/10.1038/s41589-024-01750-x

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Natural SNP Variation in GbOSM1 Promotor Enhances Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Dayong Zhang , Haitang Wang , Jinmin Kong , Zhiguo Chen , Chaofeng Ruan , Chaoyang Deng , Qihang Zheng , Zhan Guo , Hanqiao Liu, Weixi Li , Xinyu Wang , Wangzhen Guo

Journal: Advanced Science

PubMed ID: 39413014

Doi: 10.1002/advs.202406522

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4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

Authors: Rahul V G , Govindaraj Ellur , Amir A Gaber , Prem Kumar Govindappa , John C Elfar

Journal: Cell Death Discov

PubMed ID: 39366954

Doi: 10.1038/s41420-024-02199-6

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Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

Authors: Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip

Journal: J Immunother Cancer

PubMed ID: 39362791

Doi: 10.1136/jitc-2024-009129

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Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon

Journal: Nature Communications

PubMed ID: 39277599

Doi: 10.1038/s41467-024-52119-6

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Efficient circularization of protein-encoding RNAs via a novel cis-splicing system

Authors: Shaojun Qi , Huiming Wang , Guopeng Liu , Qianshan Qin , Peng Gao , Bo Ying

Journal: Nucleic Acids Research

PubMed ID: 39162233

Doi: 10.1093/nar/gkae711

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Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication

Authors: Geraldy L S Liman , Christopher W Lennon , Jaylin L Mandley , Alina M Galyon , Kelly M Zatopek , Andrew F Gardner , Thomas J Santangelo

Journal: SCIENCE ADVANCES

PubMed ID: 39292776

Doi: 10.1126/sciadv.adp4995

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Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71

Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin

Journal: VIROLOGICA SINICA

PubMed ID: 39306193

Doi: 10.1016/j.virs.2024.09.008

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Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 39271120

Doi: doi.org/10.1093/nar/gkae800

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Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales

Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji

Journal: Nucleic Acids Research

PubMed ID: 39287123

Doi: doi.org/10.1093/nar/gkae803

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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat

Journal: Cell

PubMed ID: 39255801

Doi: 10.1016/j.cell.2024.08.017

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In Situ Noninvasive Monitoring of Cell Secretions Based on MOFs/AAO Hybrid Membrane Induced Asymmetric Ion Transport

Authors: Zhaohan Wang , Yafeng Wu , Zhi Wang , Zhaoyan Tian , Yu Liu , Songqin Liu

Journal: Biosensors & bioelectronics

Doi: 10.1016/j.bios.2024.116735

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Photoexcited Cryptochrome 1 Interacts With SPCHLESS to Regulate Stomatal Development in Arabidopsis

Authors: Li Chen 1 2, Xiaoli Cao , Yupeng Li 1 2, Minqing Liu 1, Yao Liu 1, Yan Guan 1 2, Jiaqi Ruan 1, Zhilei Mao 1 2, Wenxiu Wang 1 2, Hong-Quan Yang 1 2, Tongtong Guo

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39253954

Doi: 10.1111/pce.15123

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Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy

Authors: Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202408767

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Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1–RNA interaction

Authors: Yang Tan , Zhibo Zhao , Qingfang Han , Peipei Xu , Xiaopeng Shen , Yajun Jiang , Qiang Xu , Xingxin Wu

Journal: Nucleic Acids Research

PubMed ID: 39268573

Doi: 10.1093/nar/gkae788

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PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation

Authors: Zhenwei Liang, ∙ Tao Zhu, ∙ Yaoguang Yu,∙ … ∙ Yuhai Cui ∙ Shangzhi Huang ∙ Chenlong Li

Journal: Molecular Cell

Doi: doi.org/10.1016/j.molcel.2024.08.018

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Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase

Authors: Elżbieta Wątor, Piotr Wilk, Paweł Kochanowski, Przemysław Grudnik

Journal: FEBS J

Doi: doi.org/10.1111/febs.17207

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Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia

Authors: Rui-Jin Ji , Guo-Hua Cao , Wei-Qiang Zhao , Mu-Yao Wang , Pan Gao, Yi-Zhou Zhang, Xue-Bin Wang, Hou-Yuan Qiu , Di-Di Chen, Xiao-Han Tong , Min Duan, Hao Yin, Ying Zhang

Journal: Cell Stem Cell

PubMed ID: 39353428

Doi: 10.1016/j.stem.2024.09.003

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Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice

Authors: Jia He , Chaoyu Wang , Xiao Fang , Junyao Li , Xueying Shen , Junxia Zhang , Cheng Peng , Hongjian Li , Sai Li , Jeffrey M Karp , Rui Kuai

Journal: Nature Communications

PubMed ID: 39284814

Doi: 10.1038/s41467-024-52104-z

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Antimony Component Schottky Nanoheterojunctions as UltrasoundHeightened Pyroptosis Initiators for Sonocatalytic Immunotherapy

Authors: Jihu Nie, Nailin Yang , Shumin Sun , Li Wang , Zifan Pei, Jie Wu, Qiao Yu, Zhihui Han ,Youdong Chen , Liang Cheng

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39305135

Doi: 10.1002/anie.202416426

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Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity

Authors: Lulu Ren , Jianqin Wan , Xiaoyan Li , Jie Yao , Yan Ma , Fanchao Meng , Shusen Zheng , Weidong Han , Hangxiang Wang

Journal: Nature Communications

PubMed ID: 39227567

Doi: 10.1038/s41467-024-51945-y

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EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection

Authors: Yuege Huang , Hong Mei , Chunchen Deng , Wei Wang , Chao Yuan , Yan Nie , Jia-Da Li , Jia Liu

Journal: Nature Communications

PubMed ID: 39231976

Doi: 10.1038/s41467-024-52193-w

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Rapid generation of long, chemically modified pegRNAs for prime editing

Authors: Xinlin Lei , Anhui Huang , Didi Chen , Xuebin Wang , Ruijin Ji , Jinlin Wang , Yizhou Zhang , Yuming Zhang , Shuhan Lu , Kun Zhang , Qiubing Chen , Ying Zhang , Hao Yin

Journal: Nature Biotechnology

PubMed ID: 39349835

Doi: doi.org/10.1038/s41587-024-02394-x

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A bioorthogonal probiotic platform spatiotemporally releases nanobodies in deep tumor for cancer chemoimmunotherapy

Authors: Ruiyue Chen , Qianglan Lu , Fei Zeng , Shurong Qin , Yongchun Pan , Zhiyong Liu , Yuzhen Wang , Bangshun He , Wenjin Qi , Yujun Song

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.09.002

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Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and aPD-L1 for Glioblastoma Immunotherapy

Authors: Lei Dong , Yini Zhu , Haoge Zhang , Lin Gao , Zhiqi Zhang , Xiaoxuan Xu , Leqian Ying , Lu Zhang , Yue Li , Zhengcheng Yun , Danqi Zhu , Chang Han , Tingting Xu , Hui Yang , Shenghong Ju , Xiaoyuan Chen , Haijun Zhang , Jinbing Xie

Journal: ADVANCED MATERIALS

PubMed ID: 39264011

Doi: 10.1002/adma.202407235

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Strontium-Modified porous attapulgite composite hydrogel scaffold with advanced angiogenic and osteogenic potential for bone defect repair

Authors: Chun Liu , Su Ni , Xiaoyu Wu , Linxiang Zhang , Ting Dai , Aiqin Wang , Hongbin Zhao

Journal: COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

Doi: doi.org/10.1016/j.compositesa.2024.108492

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of antimicrobial bioactive peptides from the camel milk protein lactoferrin: Molecular docking, molecular dynamic simulation, and in vitro study

Authors: Mohammed Alzain , Ehab M.M. Ali , Mazin Zamzami , Ishtiaq Qadri , Hani Choudhry , Kamel Chaieb , Bochra Kouidhi , Hisham N. Altayb

Journal: food and humanity

Doi: doi.org/10.1016/j.foohum.2024.100414

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Diffusiophoresis promotes phase separation and transport of biomolecular condensates

Authors: Viet Sang Doan , Ibraheem Alshareedah , Anurag Singh , Priya R Banerjee , Sangwoo Shin

Journal: Nature Communications

PubMed ID: 37461689

Doi: 10.1038/s41467-024-51840-6

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Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks

Authors: Li Chen , Minqing Liu , Yupeng Li , Yan Guan, Jiaqi Ruan , Zhilei Mao , Wenxiu Wang , Hong-Quan Yang , Tongtong Guo

Journal: BBRC

Doi: 10.1016/j.bbrc.2024.150233

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The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress

Authors: Ying Ma , Jiarong Guo , Haipeng Rao , Jingyu Xin , Xinyi Song , Rui Liu , Shan Shao , Jiajia Hou , Liyu Kong , Zhigang Hu , Lingfeng He , Feiyan Pan , Zhigang Guo

Journal: Journal of extracellular vesicles

PubMed ID: 39235072

Doi: 10.1002/jev2.12505

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Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

Authors: Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He

Journal: Nature Cell Biology

PubMed ID: 39300312

Doi: 10.1038/s41556-024-01499-4

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Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA

Authors: Hongzhan Xu , Jing Ye # , Kui-Xing Zhang # , Qingxi Hu , Tongxiao Cui , Chong Tong , Mengqi Wang , Huichao Geng , Kun-Ming Shui , Yan Sun , Jian Wang , Xiaomeng Hou , Kai Zhang , Ran Xie , Yafei Yin , Nan Chen , Jia-Yu Chen

Journal: nature Chemistry

PubMed ID: 39223307

Doi: 10.1038/s41557-024-01609-7

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OsFAD1–OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice

Authors: Mingxing Cheng , Huanran Yuan , Ruihua Wang , Fengfeng Fan , Fengfeng Si , Xiong Luo , Wei Liu , Shaoqing Li

Journal: Journal of integrative plant biology

PubMed ID: 39279451

Doi: doi.org/10.1111/jipb.13775

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