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Human FcRL5 is an Fc receptor that simultaneously engages two IgGs

Authors: Shihua Chen, Shuhan Li, Zhiying Zhang, Junyu Xiao

Journal: SCIENCE ADVANCES

PubMed ID: 41477863

Doi: 10.1126/sciadv.aeb8865

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Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility

Authors: Sixian Qi, Lifan Wei, Zhan Ding, Feiya Zhong, Sicong Yang, Leibin Wu, Xuan Yang, Bin Kang, Mo Dan, Jianhua Gan, Chunlei Li, Xiaoye Su

Journal: SCIENCE ADVANCES

PubMed ID: 41481737

Doi: 10.1126/sciadv.adu6505

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Argonaute-mediated RNA editing selectively repairs point mutations

Authors: Zhiwei Zhang, Jinyue Wang, Tongyu Guo, Xiaolan Yu, Fei Wang, Hang Zhang, Yang Liu, Wenqiang Li, Yibin Cheng, Yanhong Peng, Guangbo Yan, Jiakai Cui, Lixin Ma

Journal: Nucleic Acids Research

PubMed ID: 41495892

Doi: 10.1093/nar/gkaf1403

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Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase

Authors: Meimei Lan, Li Xu, Yizhen Han, Tong Cui, Zhi Qiao, Yan-Bin Teng, Na Wang, Hongyu Bao

Journal: Nucleic Acids Research

PubMed ID: 41495901

Doi: 10.1093/nar/gkaf1492

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Structure and function of the nairovirus cap-snatching endonuclease

Authors: Wenhua Kuang, Zhenhua Tian, Gan Zhang, Fan Wu, Jinyue Li, Jingjing Tang, Huanyu Zhang, Xinyue Zhuo, Zhihong Hu, Manli Wang, Haiyan Zhao, Zengqin Deng

Journal: Nucleic Acids Research

PubMed ID: 41533578

Doi: 10.1093/nar/gkaf1515

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Strategic variations in sarbecovirus and merbecovirus Nsp1 linker regions for translation inhibition

Authors: Ruixi Yan, Mingbo Wu, Xiangyu Ge, Qianqian Jin, Moyu Wang, Haolong Zhou, Yan Li, Yue Wang, Shuai Yuan

Journal: Nucleic Acids Research

PubMed ID: 41538319

Doi: 10.1093/nar/gkag017

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From Natural Discovery to AI-Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Authors: Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu

Journal: Advanced Science

PubMed ID: 41486594

Doi: 10.1002/advs.202516600

Structure-Guided Engineering of a Cas12i Nuclease Unlocks Near-PAMless Genome Editing

Authors: Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian-Kang Zhu

Journal: Advanced Science

PubMed ID: 41532605

Doi: 10.1002/advs.202516670

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A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS-STING Activation for Cancer Immunotherapy

Authors: Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang

Journal: Advanced Science

PubMed ID: 41560305

Doi: 10.1002/advs.202518356

Products & Services: Protein Electrophoresis and Western

A High Soluble-Fibre Allele in Wheat Encodes a Defective Cell Wall Peroxidase Responsible for Dimerization of Ferulate Moieties on Arabinoxylan

Authors: Rowan A C Mitchell, Ondrej Kosik, Abdul Kader Alabdullah, Anneke Prins, Maria Oszvald, Till K Pellny, Jackie Freeman, Kirstie Halsey, Caroline A Sparks, Alison Huttly, James Brett, Michelle Leverington-Waite, Simon Griffiths, Peter R Shewry, Alison Lovegrove

Journal: Plant Biotechnology Journal

PubMed ID: 41482806

Doi: 10.1111/pbi.70527

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The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

Authors: Hongcheng Cheng, Yapeng Su, Xiaoli Pan, Yue Xu, Ermei Xie, Jing Du, Daniel G Chen, Xiaomeng Dai, Raphael Gottardo, Philip D Greenberg, Guideng Li

Journal: Nature

PubMed ID: 41535474

Doi: 10.1038/s41586-025-09926-8

The visual system of the longest-living vertebrate, the Greenland shark

Authors: Lily G Fogg, Emily Tom, Maxime Policarpo, William Cho, Fangyuan Gao, Doreen Hii, Aaron E Fawcett, Nicolas Boileau, Amalie Bech-Poulsen, Kirstine F Steffensen, Cherlyn J Ng, Peter G Bushnell, John Fleng Steffensen, Richard Brill, Walter Salzburger, Dorota Skowronska-Krawczyk

Journal: Nature Communications

PubMed ID: 41491153

Doi: 10.1038/s41467-025-67429-6

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Restoration of ovarian endocrine function with encapsulated immune-isolated human ovarian xenograft in ovariectomized mice

Authors: Margaret A Brunette, Monica A Rionda, Delaney Sinko, Jordan H Machlin, Gabrielle M Blevins, Marisa Leo, Ansen Tan, Bipasha Ray, Marilia Cascalho, Vasantha Padmanabhan, Ariella Shikanov

Journal: SCIENCE ADVANCES

PubMed ID: 41477848

Doi: 10.1126/sciadv.adx6348

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Safeguarding genome integrity: Polo-like kinase Cdc5 and phosphatase Cdc14 orchestrate Topoisomerase II-mediated catenane resolution in mitosis

Authors: Lucia F Massari, Alice Finardi, Clara Visintin, Erika Calabrese, Ambra Dondi, Rosella Visintin

Journal: Nucleic Acids Research

PubMed ID: 41533572

Doi: 10.1093/nar/gkaf1509

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DNA binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid–liquid phase separation

Authors: Kim Mignon, Rani Van der Eecken, Margot Galle, Manon Demulder, Joris Van Lindt, Lieven De Veylder, Henri De Greve, Remy Loris

Journal: Nucleic Acids Research

PubMed ID: 41556342

Doi: 10.1093/nar/gkaf1522

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AI-Based D-Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug-Resistant Bacterial Infection

Authors: Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li

Journal: Advanced Science

PubMed ID: 41532671

Doi: 10.1002/advs.202518522

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A Modular Vaccine Platform Against SARS-CoV-2 Based on Self-Assembled Protein Nanoparticles

Authors: Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji-Joon Song, Meehyein Kim, Sangyong Jon

Journal: Advanced Science

PubMed ID: 41532509

Doi: 10.1002/advs.202513431

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Functional and Mechanistic Investigation of a Distinct DUF6895 Family Epimerase Involved in Lasso Peptide Modification

Authors: Menghan Shi, Yuwei Duan, Shao-Yang Hou, Liangxu Xie, Weifeng Sun, Liubin Feng, Youming Zhang, Xiaoying Bian, and Guannan Zhong

Journal: ACS catalysis

Doi: 10.1021/acscatal.5c08590

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In Vivo Generation and Manipulation of CAR-T-mimicking Cells via Magnetic Bispecific Nano-antibody for Solid Tumor Therapy

Authors: Yueqiang Zhu, Chaoran Chen, Junbin Chen, Miao Su, Wanling Huang, Sichen Liu, Mingda Yang, Chengqiong Mao, Song Shen, Xianzhu Yang, Jun Wang

Journal: Advanced materials (Deerfield Beach, Fla.)

PubMed ID: 41495981

Doi: 10.1002/adma.202520493

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Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors: S Haydar, R Bednarz, P Laurette, I Sobitov, N Díaz I Pedrosa, P Videm, T Lueneburg, S Kuß, H Lahm, M Dreßen, M Krane, C Schmidt, B A Grüning, N Voigt, K Streckfuss-Bömeke, R Gilsbach

Journal: Nature Communications

PubMed ID: 41526351

Doi: 10.1038/s41467-025-67220-7

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Wnt3a promotes in situ dentin formation through NKD1- MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells

Authors: Haoran Du, Qiong Li, Chenchen Zhou, Junji Xu, Kang Gao, Zixiao Li, Yifan Xu, Ousheng Liu, Bing Li, Jianguang Xu, Jingsong Wang, Hideaki Kagami, Xianqi Li, Su Chen, Jian Zhou

Journal: International journal of oral science

PubMed ID: 41526338

Doi: 10.1038/s41368-025-00406-3

Products & Services: Protein Electrophoresis and Western

A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

Authors: Shanshan Yu, Qiyao Chai, Zhe Lu, Changgen Qiu, Yanzhao Zhong, Yiru Wang, Zehui Lei, Lihua Qiang, Yingxu Fang, Xinwen Zhang, Bingxi Li, Mengqiu Gao, Lingqiang Zhang, Gong Cheng, Jing Wang, Cui Hua Liu, Yu Pang

Journal: Cell Host & Microbe

PubMed ID: 41475336

Doi: 10.1016/j.chom.2025.12.002

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Screening for novel variable domains of the heavy chains of heavy-chain antibodies targeting different epitopes of thrombomodulin and Luminex fluorescence immunoassay for soluble thrombomodulin

Authors: Congcong Jia, Min Zhu, Yuelan He, Meixiang Yu, Xinyi Xia, Weiwei Ji, Xiang Cao, Jianzhong Lu, Hai Zhang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41314569

Doi: 10.1016/j.ijbiomac.2025.149289

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Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

Authors: Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang, Chen Lou, Sisi Li, Mingde Lin, Xin Li, Wenchao Xu, Jiaming Zhou, Peiran Hu, Zhendong Yao, Yuan Yuan, Jianzhong Sheng, Chen Zhang, Wei Yang, Youjiang Li, Hefeng Huang

Journal: EMBO Molecular Medicine

PubMed ID: 41618099

Doi: 10.1038/s44321-026-00374-z

Products & Services: Protein Electrophoresis and Western

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Authors: Christopher J. Lupton, Charles Bayly-Jones, Shuqi Dong, Terrance Lam, Wentong Luo, Gareth D. Jones, Chantel Mastos, Nicholas J. Frescher, San S. Lim, Alastair C. Keen, Luke E. Formosa, Hari Venugopal, Yong-Gang Chang, Michelle L. Halls, Andrew M. Ellisdon

Journal: Cell

PubMed ID: 41512879

Doi: 10.1016/j.cell.2025.12.005

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Polyamine-dependent metabolic shielding regulates alternative splicing

Authors: Amaia Zabala-Letona, Mikel Pujana-Vaquerizo, Belen Martinez-Laosa, Maria Ponce-Rodriguez, Saioa Garcia-Longarte, Isabel Mendizabal, Ana Gimeno, Malgorzata Rogalska, Joycelyn Tan, Diana Cabrera, Sebastiaan van Liempd, Pilar Ximenez-Embun, Sergio Espinosa, Maider Fagoaga-Eugui, Francesca Peccati, Maciej Zakrzewski, Ianire Astobiza, Mikel Arana-Castañares, Sarah Cherkaoui, Maria Sendino, Inés Martín-Barros, Amaia Ercilla, Laura Bozal-Basterra, Onintza Carlevaris, Amaia Arruabarrena-Aristorena, Encarnación Pérez-Andrés, Telmo Santamaría-Zamorano, Juan A Ferrer-Bonsoms, Fernando Carazo, Maciej Cieśla, Cesar Lobato, Joan Seoane, Natalia Martín-Martín, Rosa Barrio, James D Sutherland, Ana M Aransay, Juan Manuel Falcón-Pérez, Barbara Martínez-Pastor, Angel Rubio, Francisco J Blanco, Michael D Hogarty, Raphael J Morscher, Edurne Berra, Remigiusz A Serwa, Jesús Jiménez-Barbero, Gonzalo Jiménez-Osés, Alejo Efeyan, Lydia Finley, Jose M Lizcano, Javier Muñoz, Juan Valcarcel, Arkaitz Carracedo

Journal: Nature

PubMed ID: 41535471

Doi: 10.1038/s41586-025-09965-1

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A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

Authors: Shihong Zhang, Tzu-Hao Tang, Sinéad Kinsella, Francesco Mazziotta, Michael T Schweizer, Megan S McAfee, Ariunaa Munkhbat, Yapeng Su, Valentin Voillet, Lauren E Martin, Colton W Smith, Yuta Asano, Menna Hailemariam, Jakob Bakhtiari, Bo Lee, Cecilia Yeung, Hung Chen, Alessandro M Rizzi, Daniel G Chen, Kelsey Furiya, Nick Horst, Tianzi Zhang, Phung Le, Kelly McKenna, Shannon K Oda, Anthony Rongvaux, Phillip D Greenberg, Thomas M Schmitt, Aude G Chapuis

Journal: Nature Communications

PubMed ID: 41484084

Doi: 10.1038/s41467-025-67446-5

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Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization

Authors: Aurélie Favarin, Rayan Said, Hong Wang, Emilie Zeine, Amaury Pierrard, Julien Pernier, Hemalatha Narassimprakash, Stéphane Roméro, Alexis M Gautreau, René-Marc Mège, Christophe Le Clainche

Journal: SCIENCE ADVANCES

PubMed ID: 41477870

Doi: 10.1126/sciadv.ady4863

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Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity

Authors: Deblin Jana, Emilia Herdes, Justin Moustouka, Kayla M Mash, Jingge Chen, Kareem Ebeid, Marwa Sallam, Akram Abbasi, Tejal Desai

Journal: SCIENCE ADVANCES

PubMed ID: 41481710

Doi: 10.1126/sciadv.aeb0452

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Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance

Authors: Amar Singh, Adam Herman, Devanjan Dey, Samuel Menge, Shilpi Singh, Anna Tran, Anders Matson, Ahmed Mourad, Parthasarathy Rangarajan, Ravi Masuria, Naoya Sato, Sarah Vadnais, Joseph Sushil Rao, Gatikrushna Singh, Melanie L Graham, Sabarinathan Ramachandran, Bernhard J Hering

Journal: SCIENCE ADVANCES

PubMed ID: 41499508

Doi: 10.1126/sciadv.aea0567

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On-demand cancer immunotherapy via single-cell encapsulation of synthetic circuit–engineered cells

Authors: Yue Zhao, Rui Li, Yirui Han, Chaochen Shi, Kyubae Lee, Guangjun Nie, Yazhou Chen

Journal: SCIENCE ADVANCES

PubMed ID: 41533781

Doi: 10.1126/sciadv.aea3573

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Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells

Authors: Xianghua Zhong, Xinchao Liu, Jiajia Luo, Xinyang Liu, Xueting Wei, Xi Peng, Lu Wang, Huaimin Wang, Kunyu Zhang, Liming Bian, Peng Shi

Journal: SCIENCE ADVANCES

PubMed ID: 41544160

Doi: 10.1126/sciadv.aea0998

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Enhanced SfaTnpB enables single-base-specific, one-pot nucleic acid detection for high-sensitivity diagnostics

Authors: Bingrong Xu, Sheng Li, Yong Li, Shuhong Zhao, Xinyun Li, Jianlin Han, Di Wu, Shuaicheng Li, Ling Chen, Shengsong Xie, Xiaosong Han, Changzhi Zhao

Journal: Nucleic Acids Research

PubMed ID: 41505099

Doi: 10.1093/nar/gkaf1433

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Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis

Authors: Joydeep Baral, Ching-Seng Ang, Paul James McMillan, Kalyan Shobhana, Ayushi Saini, Elizabeth Hinde, Amit Kumar Das, Isabelle Rouiller

Journal: Nucleic Acids Research

PubMed ID: 41521670

Doi: 10.1093/nar/gkaf1418

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G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Authors: Harrison A Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R Panchenko, Catherine A Musselman

Journal: Nucleic Acids Research

PubMed ID: 41533587

Doi: 10.1093/nar/gkaf1381

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Multilayered regulation by RNA thermometers enables precise control of Cas9 expression in E. coli

Authors: Elise K Kammerdiener, Sarah K Garcia, Margaret K Bales, Dawn M Klingeman, Adam M Guss, Richard J Giannone, Robert L Hettich, Carrie A Eckert, William G Alexander

Journal: Nucleic Acids Research

PubMed ID: 41533573

Doi: 10.1093/nar/gkaf1495

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Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Authors: Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo

Journal: Advanced Science

PubMed ID: 41560288

Doi: 10.1002/advs.202514140

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Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels in Phytophthora sojae

Authors: Jinzhu Chen, Wenhao Li, Qin Peng, Hongwei Zhu, Tan Dai, Jianqiang Miao, Xili Liu

Journal: SCIENCE ADVANCES

PubMed ID: 41533793

Doi: 10.1126/sciadv.adz2785

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Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2

Authors: Tian Wang, Yiran Wu, Ling Wang, Shanshan Li, Fei Zhao, Lijie Wu, Yue Liu, Jingzi Qin, Qiwen Tan, Junlin Liu, Liting Zeng, Yilin Chen, Shenyuan Gao, Wenqing Shui, Suwen Zhao, Tian Hua, Zhi-Jie Liu

Journal: Cell

PubMed ID: 41570822

Doi: 10.1016/j.cell.2025.12.017

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SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling

Authors: Guoyan Luo, Jia Song, Yongbo Fu, Yuanjie Jiang, Yuan Gao, Zhixing Zhong, Ling Li, Yong Wei, Hao-Ran Jia, Lu Guo, Ting Fu, Qin Wu, Weihong Tan

Journal: Science (New York, N.Y.)

PubMed ID: 41477891

Doi: 10.1126/science.adv6127

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Phage-associated Cas12p nucleases require binding to bacterial thioredoxin for activation and cleavage of target DNA

Authors: Zhipeng Wang, Yujue Wang, Hui Gao, Jiani Dai, Na Tang, Yannan Wang, Quanjiang Ji

Journal: Nature Microbiology

PubMed ID: 41492065

Doi: 10.1038/s41564-025-02224-z

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Antibody-induced internalization and degradation of PLA2R amplifies CD4+ T cell activation

Authors: Yuning Liu, Yinyin Li, Hui Zhou, Jieli Yu, Pei Deng, Weiwei Xu, Bingqian Pan, Lei Zhang, Hong Zhou, Jing Zhang, Xiaohan Liu, Min Shi, Xianchi Dong, Bei Tong, Enguang Bi, Nannan Guo, Yu Hu

Journal: Theranostics

PubMed ID: 41328348

Doi: 10.7150/thno.123035

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Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk.

Authors: Huijian Yang, Biao Yu, Ruiyang Li, Yang Hong, Mingzhu Shen, Tianzhuo Shen, Xiuhui Wang, Han Liu, Guangchao Wang, Ke Xu, Yuhai Ma, Mengmeng Li, Jiacan Su

Journal: Journal of nanobiotechnology

PubMed ID: 41530784

Doi: 10.1186/s12951-026-04021-0

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WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

Authors: Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li

Journal: Nature Communications

PubMed ID: 41565645

Doi: 10.1038/s41467-026-68623-w

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An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection

Authors: Zihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen Du

Journal: Lab on a chip

PubMed ID: 41439322

Doi: 10.1039/D5LC01096A

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Stress controls heterochromatin inheritance via histone H3 ubiquitylation

Authors: Bharat Bhatt, Yi Wei, Ashis Kumar Pradhan, Jothy Dhakshnamoorthy, Martin Zofall, Hua Xiao, Drisya Vijayakumari, Shweta Jain, Hernan Diego Folco, Hongyun Qi, David A Ball, Tatiana S Karpova, David Wheeler, Jiemin Wong, Shiv I S Grewal

Journal: Nature

PubMed ID: 41501458

Doi: 10.1038/s41586-025-09899-8

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Microbiota-induced T cell plasticity enables immune-mediated tumour control

Authors: Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Journal: Nature

PubMed ID: 41535459

Doi: 10.1038/s41586-025-09913-z

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TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Authors: Martina Spiga, Alessia Potenza, Zulma Magnani, Stefano Beretta, Barbara Camisa, Laura Conte, Alessia Airaghi, Neda Mohammadi, Laura Perani, Claudio Doglioni, Maurilio Ponzoni, Francesca Sanvito, Chiara Balestrieri, Lucia Sergi Sergi, Oronza A Botrugno, Giulio Giovannoni, Giovanni Tonon, Danilo Abbati, Chiara Iozzi, Maximilian Reichert, Hana Algul, Arianna Pocaterra, Martina Fiumara, Samuele Ferrari, Alessia Ugolini, Alice Grometto, Giulia Di Lullo, Giovanni Sitia, Giulio Belfiori, Maria Pia Protti, Renato Ostuni, Anna Mondino, Michele Reni, Stefano Crippa, Massimo Falconi, Luigi Naldini, Eliana Ruggiero, Chiara Bonini

Journal: Nature Communications

PubMed ID: 41507193

Doi: 10.1038/s41467-025-67263-w

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Arboviruses manipulate rice’s volatile emissions, protecting insect vectors from natural enemies in the field

Authors: Qing Liu, Qian Wang, Qiong Li, Weiran Wang, Qi Li, Ziyuan Peng, Yuling Jiao, Feng Cui, Ian T Baldwin, Xiaoming Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 41499511

Doi: 10.1126/sciadv.aeb5215

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Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease

Authors: Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Weiping Jia, Devendra Kumar Gupta, Stephanie Moquin, Dustin Dovala, Daniel N Bolon, Brian A Kelch, Celia A Schiffer, Nese Kurt Yilmaz

Journal: SCIENCE ADVANCES

PubMed ID: 41544157

Doi: 10.1126/sciadv.aeb0769

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FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy

Authors: Paul Miclea, Vendula Nagy-Marková, Robin Van den Eynde, Wim Vandenberg, Alina Sakhi, Alexey Bondar, Jitka Myšková, Peter Dedecker, Josef Lazar

Journal: SCIENCE ADVANCES

PubMed ID: 41544164

Doi: 10.1126/sciadv.adz5662

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Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

Authors: Corinne E Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, Jiaxi Wu, Tong Zhang, Eric Smith, Gavin Thurston, John C Lin, Jessica R Kirshner, David J DiLillo

Journal: SCIENCE ADVANCES

PubMed ID: 41564177

Doi: 10.1126/sciadv.adx9371

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Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity

Authors: Pierce Longmire, Sebastian Zeltzer, Kristen Zarrella, Olivia Daigle, Marek Svoboda, Justin M Reitsma, Scott S Terhune, Carly Bobak, Giovanni Bosco, Felicia Goodrum

Journal: Nucleic Acids Research

PubMed ID: 41533576

Doi: 10.1093/nar/gkaf1445

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Staufen dsRNA-binding domain as modules to design bifunctional antibodies for siRNA delivery

Authors: Yahui Liu, Yan Zheng, Ruolin Xu, Yanan Quan, Wanyi Tai

Journal: Nucleic Acids Research

PubMed ID: 41569158

Doi: 10.1093/nar/gkaf1539

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All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery

Authors: Parul Sirohi, Brooke E Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y Ma, Chinmay S Potnis, Soumen Saha, Xinghai Li, Max R Ney, Sarah Y Kim, Joshua J Milligan, Lixin Fan, Matthew L Becker, Daniel Reker, Ashutosh Chilkoti

Journal: Advanced Science

PubMed ID: 41549226

Doi: 10.1002/advs.202517048

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Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.

Authors: James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel Dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki

Journal: Molecular Therapy

PubMed ID: 41566775

Doi: 10.1016/j.ymthe.2026.01.019

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Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody

Authors: Melanie Scherer, Nadia Djabeur, Oliver Siering, Jean-Marc Jeckelmann, Marianne Wyss, Marina Cresci, Morgane Di Palma Subran, Rainer Riedl, Patrick Chames, Christian K Pfaller, Bevan Sawatsky, Dimitrios Fotiadis, Philippe Plattet

Journal: Nature Communications

PubMed ID: 41501035

Doi: 10.1038/s41467-025-67600-z

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ERECTA genes and their ligands regulate shoot and inflorescence architecture in maize

Authors: Xiao Liu, Jinbiao Wang, Jipeng Li, Lu Kang, Mengyan Wang, Zhaoyu Huang, Jarrett Man, Xuxu Huang, Zhiming Zhang, Fang Yang, Madelaine Bartlett, Liuji Wu, Zhaobin Dong, David Jackson, Fang Xu

Journal: Nature Communications

PubMed ID: 41526346

Doi: 10.1038/s41467-025-67634-3

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Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems

Authors: Abdelkader Mellouk, Kenny Ngo, Ahmad A Kezzo, Cyrielle Martini, Tanos C C França, Steven R Laplante, Salim T Islam, Charles Calmettes

Journal: Nature Communications

PubMed ID: 41545361

Doi: 10.1038/s41467-025-67321-3

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Metal ions govern coronavirus endoribonuclease activity

Authors: Xionglue Wang, Jing Li, Zhichao Liu, Longfei Wang, Bin Zhu

Journal: Nucleic Acids Research

PubMed ID: 41533565

Doi: 10.1093/nar/gkaf1508

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Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides

Authors: Anirban Das, Ushasi Pramanik, Elise M Brown, Chih-Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E Jackrel, Mark A White, Jai S Rudra

Journal: Advanced Science

PubMed ID: 41560329

Doi: 10.1002/advs.202518567

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Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Authors: Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao-Lin Chen, Deng Chen

Journal: Advanced Science

PubMed ID: 41556236

Doi: 10.1002/advs.202518269

Targeting WTAP/ROR1/WNT5A-Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Authors: Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai

Journal: Advanced Science

PubMed ID: 41562250

Doi: 10.1002/advs.202520661

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Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Authors: Jun Nagai, Madeline M Hastings, Airi Nishida, Sreyashi Majumdar, Kendall Zaleski, Sofia A Marshall, Junrui Lin, Mira A S Saliman, Yumi Tani, Yamato Murakami, Chunli Feng, Alexander Perniss, Caitlin Wong, Lora G Bankova, Asuka Inoue, Nora A Barrett, Joshua A Boyce

Journal: Cell Reports

PubMed ID: 41422505

Doi: 10.1016/j.celrep.2025.116758

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Cooked meat-derived extracellular vesicles ssc-miR-1 induces metabolic disorders in the mice liver via PI3k/AKT pathway

Authors: Linyuan Shen, Jianfeng Ma, Shuang Liang, Yiting Yang, Tianci Liao, Yuhang Lei, Lei Chen, Yan Wang, Ye Zhao, Lili Niu, Mailin Gan, Li Zhu

Journal: NPJ science of food

PubMed ID: 41577711

Doi: 10.1038/s41538-026-00709-7

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DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity

Authors: Lijian Wang, Yutong Guo, Yujie Dai, Wangsheng Sun, Xiaoying Huang, Haipeng Lei, Aiping Zhang, Shuwen Chen, Yiting Li, Jiani Pan, Yangjian Hong, Lingchuan Ma, Yangyang Feng, Fangyuan Shao, Jianming Zeng, Peng Luo, Junqi Li, Weiting Chen, Na Zhou, Yang Li, Heng Sun, Xiaoling Xu, Chu-Xia Deng, Kai Miao

Journal: Journal for ImmunoTherapy of Cancer

PubMed ID: 41611244

Doi: 10.1136/jitc-2025-013142

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CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation

Authors: Jae Yeon Hwang, Huafeng Wang, Jong-Nam Oh, Jingon Kim, Sarah F Finnegan, Niels E Skakkebaek, Jean-Ju Chung

Journal: Science advances

PubMed ID: 41604475

Doi: 10.1126/sciadv.adw341

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IgG-Bridging–Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody

Authors: Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li-Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

PubMed ID: 41355083

Doi: 10.1002/advs.202517192. Online ahead of print.

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Thermodynamic Profiling Reveals DNA Polymerase Template Binding, Substrate Incorporation, and Exonuclease Function

Authors: Yaping Sun, Wu Lin, Kang Fu, Jie Gao, Xianhui Zhao, Yun He, Hui Tian

Journal: International Journal of Molecular Sciences

Doi: doi.org/10.3390/ijms262411909

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Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity

Authors: Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Journal: The Biochemical journal

PubMed ID: 41003242

Doi: doi.org/10.1042/BCJ20253431

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Iterative Epitope Expansion Enables Structure-Guided de novo Design of IgE-Binding Miniproteins Targeting the FcεRI Interface

Authors: Ido Calman, Hamed Shaykhalishahi, Puwanat Sangkhapreecha, Sharrol Bachas

Journal: biorxiv

Doi: 10.64898/2025.12.27.696647

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A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering

Authors: Ding Luo, Huining Ji, Baodong Hu, Jinxing Cai, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao, Binju Wang

Journal: ANGEWANDTE CHEMIE

PubMed ID: 41410226

Doi: 10.1002/anie.202521396

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Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Authors: Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong-Hui Zheng

Journal: Advanced Science

PubMed ID: 41324484

Doi: 10.1002/advs.202519256

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U-Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Authors: Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu

Journal: Advanced Science

PubMed ID: 41354635

Doi: 10.1002/advs.202508498

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Authors: Sangwoo Park, Cassidy E Ho, Eli P Darnell, Alexandra N Wolff, Hana Takei, Filippo Birocchi, Amanda A Bouffard, Diego Salas-Benito, Giulia Escobar, Mark B Leick, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41372740

Doi: 10.1038/s41467-025-66102-2

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

Authors: Anna Minello, Jesus Gomez-Escudero, Sreerama Chaitanya Sridhara, Charlotte Martin, Elodie Girard, Juan C Cañas, Yasin Memari, Maria Rose Bustos, Antonio Galarreta, Virginie Boucherit, Evgeny Imyanitov, Sigridur Klara Bodvarsdottir, Sylvain Baulande, Anne Vincent-Salomon, Nicolas Servant, Matthias Altmeyer, Stefan Sigurdsson, Dominique Stoppa-Lyonnet, Serena Nik-Zainal, Aura Carreira

Journal: Nature Communications

PubMed ID: 41372141

Doi: 10.1038/s41467-025-67209-2

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HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA

Authors: Alfred M Lentzsch, Ziyi Fan, Inayat U Irshad, Edward P O'Brien, Ajeet K Sharma, Rachel Green, Shu-Ou Shan

Journal: Molecular Cell

PubMed ID: 41380682

Doi: 10.1016/j.molcel.2025.11.017

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Collision-induced ribosome degradation driven by ribosome competition and translational perturbations

Authors: Sihan Li, Okuto Shounai, Misaki Kato, Ken Ikeuchi, Toshifumi Inada

Journal: Nature Communications

PubMed ID: 41387539

Doi: 10.1038/s41467-025-66026-x

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Gut Microbe-Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Authors: Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao

Journal: Advanced Science

PubMed ID: 41386783

Doi: 10.1002/advs.202520326

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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Authors: Ming-You Shie, Shi-Wei Huang, Yeh Chen, Mei-Chih Chen, Chih-Ming Pan, Cheng-Yu Chen, Yen-Hong Lin, Min-Hua Yu, Kai-Wen Kan, Shao-Chih Chiu, Hui-Chun Ho, Yi-Wen Chen, Der-Yang Cho

Journal: Nature Communications

PubMed ID: 41390497

Doi: 10.1038/s41467-025-66451-y

The Human T-cell Leukemia Virus capsid protein is a potential drug target

Authors: Ruijie Yu, Prabhjeet Phalora, Nan Li, Till Böcking, David Anthony Jacques

Journal: Nature Communications

PubMed ID: 41345105

Doi: 10.1038/s41467-025-65899-2

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors

Authors: Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu

Journal: Advanced Science

PubMed ID: 41388583

Doi: 10.1002/advs.202512342

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Protein-nucleic acid language model-assisted design of precise and compact adenine base editor

Authors: Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Journal: Nature Communications

PubMed ID: 41390734

Doi: 10.1038/s41467-025-65311-z

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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma

Authors: Yan Huang, Shaoli Liu, Xiaoju Zhang, Bingxu Zhang, Feng Shi, Jia Zhang, Shuaibo Shao, Hongya Han, Xiaoyun Ma, Jing Xie, Jianqi Zhang, Hongxiaoying Yu, Yongchao Zhao, Jiazheng Jin, Dong Xu, Liang Liu, Jianing Wang, Yu Tan, Kelu Xu, Lushuai Jin, Quanjun Du, Yifeng Geng, Andong Liu, Wei Xu

Journal: Nature Communications

PubMed ID: 41397962

Doi: 10.1038/s41467-025-66087-y

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Molecular insights into ligand recognition and signaling of OXGR1

Authors: Aijun Liu, Yezhou Liu, Yuanzhengyang Long, Richard D Ye

Journal: Nature Communications

PubMed ID: 41413034

Doi: 10.1038/s41467-025-67101-z

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Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

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Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

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RING- Type E3 Ligase OsRFPH2- 6 Ubiquitinates Nuclear Factor Y Subunit OsNF- YA1 to Suppress Rice Immunity

Authors: Yan Bi, Leeza Tariq, Hui Wang, Yuqing Yan, Dayong Li, Fengming Song

Journal: Molecular plant pathology

PubMed ID: 41424058

Doi: 10.1111/mpp.70193

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Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

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Structural basis of microtubule-mediated signal transduction

Authors: Sung Ryul Choi, Thorsten B Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D Gossert, G V Shivashankar, Alfred Zippelius, Michel O Steinmetz

Journal: Cell

PubMed ID: 41365297

Doi: 10.1016/j.cell.2025.11.011

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Authors: Zilong Wang, Seokjung Cheong, Jose Henrique Pereira, Weixi Hu, Yifan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W Haushalter, Taek Soon Lee, Paul D Adams, Jay D Keasling

Journal: Nature Communications

PubMed ID: 41365852

Doi: 10.1038/s41467-025-65946-y

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Authors: Joshua Tomkins, Lucy V Edwardes, Sarah V Faull, Matthew Peach, Peter J Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J Julian Blow, Alexis R Barr, Anna Barnard, Christian Speck

Journal: Nature Communications

PubMed ID: 41365879

Doi: 10.1038/s41467-025-67073-0

Induced Proprioceptor and Low-Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Authors: Amy J Hulme, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Nicholas R Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J Adams, Mirella Dottori

Journal: Advanced Science

PubMed ID: 41364594

Doi: 10.1002/advs.202512413

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TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Authors: Maria G Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F Winklhofer

Journal: Advanced Science

PubMed ID: 41405403

Doi: 10.1002/advs.202509927

Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases

Authors: Min Kyung Shinn, Dylan T Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M Ruff, Gregory W Strout, Matthew D Lew, Kannanganattu V Prasanth, Rohit V Pappu

Journal: Cell

PubMed ID: 41421357

Doi: 10.1016/j.cell.2025.11.026

Synthesis of Bispecific Conjugates by ADP-Ribosyl Cyclases

Authors: Sunny H Kim, Arshad J Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B Katz, Yong Zhang

Journal: Advanced Science

PubMed ID: 41422434

Doi: 10.1002/advs.202518329

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A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Authors: Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S L Parker, Yingying Guo, Dongming Zhou

Journal: Advanced Science

PubMed ID: 41431149

Doi: 10.1002/advs.202512262

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Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Authors: Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang

Journal: Journal of enzyme inhibition and medicinal chemistry

PubMed ID: 41395810

Doi: 10.1080/14756366.2025.2593798

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Supramolecular lipid nanoparticle reprograms tumor microenvironment by cucurbit[7]uril-based host–guest recognition for STING-activating cancer immunotherapy

Authors: Yunxuan Feng, Yuan Yu, Xinyang Yu, Mengyao Li, Jiaqi Lei, Yongcan Li, Zhida Liu, Shaolong Qi, Guocan Yu

Journal: Materials Today

Doi: doi.org/10.1016/j.mattod.2025.11.029

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