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Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale
Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin
Journal: Cell
PubMed ID: 38936359
Doi: 10.1016/j.cell.2024.05.056
Products & Services: Custom RNAi Services   
Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer
Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri
Journal: Mol Cancer Ther
PubMed ID: 38638035
Doi: 10.1158/1535-7163.MCT-23-0766
Products & Services: Gene Synthesis   
Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia
Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue
Journal: biorxiv
Doi: 2024.07.26.605286
Products & Services: Gene Synthesis   
Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system
Authors: Danping Zhang 1, Liyang Du 1, Haishan Gao 2 3, Cai Yuan 4, Zhonghui Lin 1
Journal: Nucleic Acids Res
PubMed ID: 38967023
Doi: 10.1093/nar/gkae569
Products & Services: Gene Synthesis   
The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis
Authors: Lei Shi, Changjiang Li, Gaofeng Lv, Xing Li, Wutao Feng, Yujing Bi, Wenhui Wang, Youqun Wang, Lei Zhu, Wenqiang Tang, Ying Fu
Journal: Plant Cell
PubMed ID: 38526222
Doi: 10.1093/plcell/koae086
Products & Services: Gene Synthesis   
Impact of Equilibrative Nucleoside Transporters TgAT1, TgENT1, and TgENT3 on Toxoplasma gondii Infection and Differentiation
Authors: Amber Goerner, Gabriel Messina, Lea Drogalis Beckham, Bruno Martorelli Di Genova
Journal: biorxiv
Doi: doi.org/10.1101/2024.07.10.601519
Products & Services: Gene Synthesis   
Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum
Authors: Zhengjie Wang, Ruili Lv, Chenglin Su, Yan Li, Sizhe Fang, Ruirui Yang, Jiaxuan Zhu, Ruiming Wang, Jun Meng, Yushi Luan
Journal: J Agric Food Chem
PubMed ID: 38994823
Doi: 10.1021/acs.jafc.4c03588
Products & Services: Peptide Synthesis   
Comparative biochemistry of PET hydrolase-carbohydrate-binding module fusion enzymes on a variety of PET substrates
Authors: Andrew Philip Rennison , Andreas Prestel , Peter Westh , Marie Sofie Møller
Journal: Enzyme and Microbial Technology
PubMed ID: 39047349
Doi: 10.1016/j.enzmictec.2024.110479
Products & Services: Gene Synthesis   Mutagenesis Services   
Mechanism of ceramide synthase inhibition by fumonisin B1
Authors: Zike Zhang 1 2 4, Qi Fang 1 2 4, Tian Xie 1 2, Xin Gong
Journal: Structure
Doi: 10.1016/j.str.2024.06.002
Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity
Authors: Moisés Alejandro Alejo Hernandez , Katia Pamela Villavicencio Sánchez , Rosendo Sánchez Morales , Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez , Eddie Guillermo Sanchez-Rueda , Yanet Teresa-Cruz , Brian Choi, Armando Hernández Garcia , Alba Romero-Rodríguez, Oscar Juárez , Siseth Martínez-Caballero , Mario Figueroa , Corina-Diana Ceapă
Journal: Beilstein Journal of Organic Chemistry
PubMed ID: 39109298
Doi: 10.3762/bjoc.20.159
Products & Services: Gene Synthesis   
Acceptors stability modulates the efficiency of post-translational protein N-glycosylation
Authors: Paula M Couto, Carlos M A Guardia, Facundo L Couto, Carlos A Labriola, María S Labanda, Julio J Caramelo
Journal: FASEB J
PubMed ID: 38934375
Doi: 10.1096/fj.202302267R
Integration of validated functional evidence to support the pathogenicity of KCNH2 variants
Authors: Reema W Aljassar, Qianyi Shen, Buthaina Albash, Jamie I Vandenberg, Mohammad A Ebrahim, Chai-Ann Ng
Journal: Genet Med Open
PubMed ID: 39669639
Doi: 10.1016/j.gimo.2024.101868
Products & Services: Gene Synthesis   
Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner
Authors: Lin-Chao Yu, Rui He, Dao-Xin Wang, Di Qi
Journal: Am J Respir Cell Mol Biol
PubMed ID: 38574235
Doi: 10.1165/rcmb.2024-0017OC
Products & Services: Molecular Biology Reagents   
METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA
Authors: Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu
Journal: Hereditas
PubMed ID: 38956710
Doi: 10.1186/s41065-024-00317-z
Products & Services: Mutant Libraries   
Screening L-Lysine-Overproducing Escherichia coli Using Artificial Rare Codons and a Rare Codon-Rich Marker
Authors: Shen Li , Tianhao Xu , Xinru Meng , Yujuan Yan , Ying Zhou , Lei Duan , Yulong Tang , Li Zhu & Litao Sun
Journal: Nucleic Acids Research
PubMed ID: 38989624
Doi: doi.org/10.3390/
Products & Services: Gene Synthesis   
DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants
Authors: Bingbing Yu , Yifan Chen , Yan Yan , Xueling Lu , Bin Zhu
Journal: Nucleic Acids Res
PubMed ID: 38979568
Doi: 10.1093/nar/gkae593
Products & Services: Gene Services   
Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice
Authors: Yan Wang , Jing Zhang , Ying Liu , Xiao Yue , Kun Han , Zhichao Kong , Yuanmin Dong , Zhenmei Yang , Zhipeng Fu , Chunwei Tang , Chongdeng Shi , Xiaotian Zhao , Maosen Han , Zhibin Wang , Yulin Zhang , Chen Chen , Anning Li , Peng Sun , Danqing Zhu , Kun Zhao , Xinyi Jiang
Journal: Sci Adv
PubMed ID: 38865465
Doi: 10.1126/sciadv.ado4791
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7
Authors: Christian J Muñoz Sosa , Christopher Lenz , Anton Hamann , Frederic Farges , Johannes Dopfer , Andreas Krämer , Veronika Cherkashyna , Andrey Tarnovskiy , Yurii S Moroz , Ewgenij Proschak , Václav Němec , Susanne Müller , Krishna Saxena , Stefan Knapp
Journal: ACS Chem Biol
PubMed ID: 38934237
Doi: 10.1021/acschembio.4c00301
Products & Services: Gene Synthesis   
Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells
Authors: Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn
Journal: J Mol Cell Biol
PubMed ID: 38253401
Doi: 10.1093/jmcb/mjae003
Products & Services: Mutant Libraries   
Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals
Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang
Journal: Small Methods
PubMed ID: 38864527
Doi: 10.1002/smtd.202400664
Products & Services: Molecular Biology Reagents   
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Authors: Huasong Ai , Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li , Man Pan , Lei Liu
Journal: Nat Struct Mol Biol
PubMed ID: 38918638
Doi: doi.org/10.1038/s41594-024-01342-2
Products & Services: Codon Optimization   
The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart
Authors: Elena Tsisanova, Muriel Nobles, Sonia Sebastian, Keat-Eng Ng, Alison Thomas, Lee Scott Weinstein, Patricia B Munroe, Andrew Tinker
Journal: J Biol Chem
PubMed ID: 38879012
Doi: 10.1016/j.jbc.2024.107470
Products & Services: Molecular Biology Reagents   
Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins
Authors: Piotr Kolesiński, Matthew McGowan, Anne Botteaux, Pierre R Smeesters, Partho Ghosh
Journal: J Biol Chem
PubMed ID: 38879009
Doi: 10.1016/j.jbc.2024.107478
Synthetic genomes unveil the effects of synonymous recoding
Authors: Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Dawn Chen, Jenny Ahn, Owen Spencer, Venkat Ayalavarapu, Angela Tarver, Miranda Harmon-Smith, Matthew Hamilton, Ian Blaby, Yasuo Yoshikuni, Behnoush Hajian, Adeline Jin, Balint Kintses, Monika Szamel, Viktoria Seregi, Yue Shen, Zilong Li, George M Church
Journal: biorxiv
PubMed ID: 38915524
Doi: 10.1101/2024.06.16.599206
Products & Services: Gene Synthesis   
The Human Genetic Differences in the Outcomes of mRNA Vaccination against COVID-19: A Prospective Cohort Study
Authors: Ha-Eun Ryu, Jihyun Yoon, Ja-Eun Choi, Seok-Jae Heo, Kyung-Won Hong, Dong-Hyuk Jung
Journal: Vaccines (Basel)
PubMed ID: 38932355
Doi: 10.3390/vaccines12060626
Products & Services: Molecular Biology Reagents   
PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation
Authors: Antonio Ruiz-Albor, Belén Chaves-Arquero, Inés Martín-Barros, Alejandra Guerra-Castellano, Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Nekane Merino, Mariola Ferreras-Gutiérrez, Edurne Berra, Irene Díaz-Moreno, Francisco J Blanco
Journal: Int J Biol Macromol
PubMed ID: 38880460
Doi: 10.1016/j.ijbiomac.2024.133187
Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline
Authors: Brenna Norton-Baker, Mackenzie C R Denton, Natasha P Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P Gauthier, Gregg T Beckham
Journal: Sci Rep
PubMed ID: 38914665
Doi: 10.1038/s41598-024-64938-0
Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression
Authors: Jun-Sheng Ni, Si-Yuan Fu, Zong-Yan Wang, Wen-Bin Ding, Jian Huang, Xing-Gang Guo, Fang-Ming Gu
Journal: J Gene Med
PubMed ID: 38860366
Doi: 10.1002/jgm.3693
Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14
Authors: Drayson Graves, Nikolas Akkerman, Lauren Fulham, Rafe Helwer, Peter Pelka
Journal: MBio
PubMed ID: 38940561
Doi: 10.1128/mbio.01038-24
TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry
Authors: Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan
Journal: biorxiv
PubMed ID: 38895352
Doi: 10.1101/2024.06.04.597282
In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade
Authors: Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu
Journal: Immunol Lett
PubMed ID: 38925442
Doi: 10.1016/j.imlet.2024.106887
RcOST1L phosphorylates RcPIF4 for proteasomal degradation to promote flowering in rose
Authors: Jingjing Sun, Hongchi Liu, Weinan Wang, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jun Lu, Jinyi Liu, Changquan Wang
Journal: New Phytol
PubMed ID: 38849320
Doi: 10.1111/nph.19885
Products & Services: Gene Synthesis   
Characterization of Two Glycoside Hydrolases of Family GH13 and GH57, Present in a Polysaccharide Utilization Locus (PUL) of sp SGAir0037
Authors: Hilda Hubertha Maria Bax, Edita Jurak
Journal: Molecules
PubMed ID: 38930854
Doi: 10.3390/molecules29122788
Products & Services: Molecular Biology Reagents   
Metal binding feature of copper‒induced metallothionein from freshwater crab Sinopotamon henanense reveals its Cu‒thionein character
Authors: Huizhen Yang, Ziyan Zhao, Hongquan Li, Lan Wang
Journal: Protein Expr Purif
PubMed ID: 38830441
Doi: 10.1016/j.pep.2024.106519
Products & Services: Gene Synthesis   
Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing
Authors: Yaoqi Sun, Bing Xiong, Xueqian Shuai, Jiale Li, Chunyan Wang, Jing Guo, Zhongping Cheng, Shupeng Liu
Journal: Mol Med
PubMed ID: 38867190
Doi: 10.1186/s10020-024-00849-0
Products & Services: Catalog Peptides   
Surface functionalization of virus-like particles via bioorthogonal click reactions for enhanced cell-specific targeting
Authors: Chavee Laomeephol, Supannikar Tawinwung, Koramit Suppipat, Wanatchaporn Arunmanee, Qian Wang, Jittima Amie Luckanagul
Journal: Int J Pharm
PubMed ID: 38866085
Doi: 10.1016/j.ijpharm.2024.124332
Developing deprotectase biocatalysts for synthesis
Authors: Lisa Kennedy, Mariyah Sajjad, Michael A Herrera, Peter Szieber, Natasza Rybacka, Yinan Zhao, Craig Steven, Zainab Alghamdi, Ivan Zlatkov, Julie Hagen, Chloe Lauder, Natalie Rudolfova, Magdalena Abramiuk, Karolina Bolimowska, Daniel Joynt, Angelica Lucero, Gustavo Perez Ortiz, Annamaria Lilienkampf, Alison N Hulme, Dominic J Campopiano
Journal: Faraday Discuss
PubMed ID: 38856717
Doi: 10.1039/d4fd00016a
Products & Services: Gene Synthesis   
Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation
Authors: Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang
Journal: Mol Med
PubMed ID: 38867145
Doi: 10.1186/s10020-024-00854-3
MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT
Authors: Yen-Nien Liu, Wei-Yu Chen, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Phan Vu Thuy Dung, Zi-Qing Chen, Wei-Jiunn Lee, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen
Journal: Sci Signal
PubMed ID: 38861615
Doi: 10.1126/scisignal.adc9142
Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis
Authors: Elisa Perez-Moreno, Tomás Toledo, Pascale Campusano, Sebastián Zuñiga, Lorena Azócar, Teo Feuerhake, Gonzalo P Méndez, Mariana Labarca, Francisca Pérez-Molina, Adely de la Peña, Cristian Herrera-Cid, Pamela Ehrenfeld, Alejandro S Godoy, Alfonso González, Andrea Soza
Journal: Biomed Pharmacother
PubMed ID: 38936192
Doi: 10.1016/j.biopha.2024.116923
Unveiling of the Co-Infection of Peste des Petits Ruminants Virus and Caprine Enterovirus in Goat Herds with Severe Diarrhea in China
Authors: Qun Zhang, Xuebo Zheng, Fan Zhang, Xuyuan Cui, Naitian Yan, Junying Hu, Yidi Guo, Xinping Wang
Journal: Viruses
PubMed ID: 38932277
Doi: 10.3390/v16060986
Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth
Authors: Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer
Journal: Cell Death Differ
PubMed ID: 38858548
Doi: 10.1038/s41418-024-01319-0
Products & Services: Molecular Biology Reagents   
Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody
Authors: Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-Anong Juntit, Umpa Yasamut, Nuchjira Takheaw, Watchara Kasinrerk, Phenphichar Wanachantararak, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Nutjeera Intasai, Chatchai Tayapiwatana
Journal: Int J Mol Sci
PubMed ID: 38928332
Doi: 10.3390/ijms25126626
Products & Services: Codon Optimization   
A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion
Authors: Desmond Richmond-Buccola, Samuel J Hobbs, Jasmine M Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S Y Lee, Philip J Kranzusch
Journal: Cell Host Microbe
PubMed ID: 38917809
Doi: 10.1016/j.chom.2024.05.021
Dissecting the dynamics of SARS-CoV-2 reinfections in blood donors with pauci- or asymptomatic COVID-19 disease course at initial infection
Authors: Alexandra Domnica Hoeggerl, Verena Nunhofer, Lisa Weidner, Wanda Lauth, Georg Zimmermann, Natalie Badstuber, Christoph Grabmer, Orkan Kartal, Christof Jungbauer, Heidrun Neureiter, Nina Held, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger
Journal: Infect Dis (Lond)
PubMed ID: 38869944
Doi: 10.1080/23744235.2024.2367112
Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset
Authors: Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudio Franceschi, Ivan Doykov, Justyna Śpiewak, Héloїse Vinette, Claudia Trenkwalder, Wendy E Heywood, Kevin Mills, Brit Mollenhauer
Journal: Nat Commun
PubMed ID: 38890280
Doi: 10.1038/s41467-024-48961-3
Products & Services: Peptide Synthesis   
SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution
Authors: Yao Yao, Zhiwei Zhou, Xiaoling Wang, Zhirui Liu, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue, Shuquan Rao
Journal: Cell Genom
PubMed ID: 38889719
Doi: 10.1016/j.xgen.2024.100583
Products & Services: Synthetic sgRNA and crRNA Service   
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
Authors: Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens
Journal: Nat Struct Mol Biol
PubMed ID: 38918639
Doi: 10.1038/s41594-024-01338-y
Products & Services: Gene Synthesis   
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Authors: Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde
Journal: Nat Metab
PubMed ID: 38871982
Doi: 10.1038/s42255-024-01061-4
Products & Services: Molecular Biology Reagents   
GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening
Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner
Journal: ACS Omega
PubMed ID: 38947828
Doi: 10.1021/acsomega.4c01583
Products & Services: Gene Synthesis   
Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China
Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu
Journal: BMC Plant Biol
PubMed ID: 38851686
Doi: 10.1186/s12870-024-05189-z
Products & Services: PCR Cloning and Subcloning   
CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p
Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie
Journal: Genesis
PubMed ID: 38764323
Doi: 10.1002/dvg.23599
Products & Services: Mutant Libraries   
N-terminal cysteine acetylation and oxidation patterns may define protein stability
Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman
Journal: Nat Commun
PubMed ID: 38918375
Doi: 10.1038/s41467-024-49489-2
Products & Services: Catalog Peptides   
Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium
Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti
Journal: Int J Biol Macromol
PubMed ID: 38944065
Doi: 10.1016/j.ijbiomac.2024.133449
Products & Services: Gene Synthesis   
A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis
Authors: Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang
Journal: Free Radic Biol Med
PubMed ID: 38945457
Doi: 10.1016/j.freeradbiomed.2024.06.025
Products & Services: Molecular Biology Reagents   
Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis
Authors: Jianwei Liu, Dixing Lin, Jiadong Lu
Journal: Cell Mol Biol (Noisy-le-grand)
PubMed ID: 38836662
Doi: 10.14715/cmb/2024.70.6.29
Products & Services: Custom Vector Construction   
Characterization of a novel carboxylesterase from Streptomyces lividans TK24 and site-directed mutagenesis for its thermostability
Authors: Jinxin Fang, Lihua An, Jiao Yu, Jinxue Ma, Rongjie Zhou, Baojuan Wang
Journal: J Biosci Bioeng
PubMed ID: 38871580
Doi: 10.1016/j.jbiosc.2024.05.001
Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG antibodies
Authors: Wen-Ting K Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J Carter
Journal: MAbs
PubMed ID: 38845069
Doi: 10.1080/19420862.2024.2362789
Products & Services: Gene Synthesis   
Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein
Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch
Journal: Nat Commun
PubMed ID: 38909062
Doi: 10.1038/s41467-024-49693-0
Products & Services: DNA Sequencing   
Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression
Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo
Journal: Sci Rep
PubMed ID: 38942821
Doi: 10.1038/s41598-024-66020-1
Products & Services: Molecular Biology Reagents   
Protein disulfide isomerase is essential for spermatogenesis in mice
Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu
Journal: JCI Insight
PubMed ID: 38912589
Doi: 10.1172/jci.insight.177743
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination
Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia
Journal: Antiviral Res
PubMed ID: 38901738
Doi: 10.1016/j.antiviral.2024.105937
Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini
Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu
Journal: Plant Physiol Biochem
PubMed ID: 38879985
Doi: 10.1016/j.plaphy.2024.108843
Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly
Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem
Journal: PLoS Pathog
PubMed ID: 38900818
Doi: 10.1371/journal.ppat.1012300
Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments
Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni
Journal: J Med Microbiol
PubMed ID: 38935078
Doi: 10.1099/jmm.0.001836
Products & Services: Gene Synthesis   
Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis
Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky
Journal: J Mol Biol
PubMed ID: 38871177
Doi: 10.1016/j.jmb.2024.168652
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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng
Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu
Journal: Int J Biol Macromol
PubMed ID: 38945337
Doi: 10.1016/j.ijbiomac.2024.133446
Products & Services: Gene Synthesis   
AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6
Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao
Journal: Plant Physiol
PubMed ID: 38535832
Doi: 10.1093/plphys/kiae186
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens
Journal: Acta Neuropathologica
PubMed ID: 38884646
Doi: 10.1007/s00401-024-02752-8
Products & Services: DNA Sequencing   
Structural insights into somatostatin receptor 5 bound with cyclic peptides
Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang
Journal: Acta Pharmacol Sin
PubMed ID: 38926478
Doi: 10.1038/s41401-024-01314-8
Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape
Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia
Journal: Plant Sci
PubMed ID: 38942388
Doi: 10.1016/j.plantsci.2024.112172
Products & Services: Gene Synthesis   
Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli
Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello
Journal: Pharmaceutics
PubMed ID: 39065546
Doi: 10.3390/pharmaceutics16070850
Products & Services: Peptide Synthesis   
ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells
Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato
Journal: Mutat Res
PubMed ID: 39024734
Doi: 10.1016/j.mrfmmm.2024.111871
Products & Services: CRISPR Plasmids   
Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming
Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding
Journal: Adv Sci (Weinh)
PubMed ID: 38923275
Doi: 10.1002/advs.202309314
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens
Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun
Journal: Marine Life Science & Technology
Doi: //doi.org/10.1007/s42995-024-00237-x
Self-assembled protein vesicles as vaccine delivery platform to enhance antigen-specific immune responses
Authors: Yirui Li, Mariela R Rodriguez-Otero, Julie A Champion
Journal: Biomaterials
PubMed ID: 38879893
Doi: 10.1016/j.biomaterials.2024.122666
Products & Services: Molecular Biology Reagents   
Expanding the genetic toolbox for the obligate human pathogen
Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier
Journal: Front Bioeng Biotechnol
PubMed ID: 38911550
Doi: 10.3389/fbioe.2024.1395659
Products & Services: Gene Synthesis   
Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases
Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth
Journal: Pancreatology
PubMed ID: 38876922
Doi: 10.1016/j.pan.2024.06.003
Products & Services: Gene Synthesis   
Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy
Authors: Jay Kumar, Renu A Kowluru
Journal: Mitochondrion
PubMed ID: 38944370
Doi: 10.1016/j.mito.2024.101925
Products & Services: Gene Synthesis   
An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor
Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang
Journal: J Agric Food Chem
PubMed ID: 38847536
Doi: 10.1021/acs.jafc.4c02968
Products & Services: Recombinant Proteins   
APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling
Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang
Journal: Cell Mol Biol Lett
PubMed ID: 38867189
Doi: 10.1186/s11658-024-00600-x
Products & Services: Catalog Peptides   
The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis
Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem
Journal: biorxiv
PubMed ID: 38948822
Doi: 10.1101/2024.06.18.599616
Products & Services: Molecular Biology Reagents   
Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan
Journal: Stem Cell Res Ther
PubMed ID: 38926849
Doi: 10.1186/s13287-024-03792-3
Products & Services: Gene Synthesis   
CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy
Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian
Journal: Blood Adv
PubMed ID: 38564778
Doi: 10.1182/bloodadvances.2023012202
Products & Services: Codon Optimization   
Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland
Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen
Journal: Microb Biotechnol
PubMed ID: 38829370
Doi: 10.1111/1751-7915.14466
Products & Services: Gene Synthesis   
Comparative Analysis of Orthosteric and Allosteric GLP-1R Agonists' Effects on Insulin Secretion from Healthy, Diabetic, and Recovered INS-1E Pancreatic Beta Cells
Authors: Joshua Reed, Victoria Higginbotham, Stephen Bain, Venkateswarlu Kanamarlapudi
Journal: Int J Mol Sci
PubMed ID: 38928038
Doi: 10.3390/ijms25126331
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Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography
Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu
Journal: J Chromatogr A
PubMed ID: 38905946
Doi: 10.1016/j.chroma.2024.465107
Products & Services: Molecular Biology Reagents   
The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats
Authors: Xin Fang, Richa Tiwary, Vivian P Nguyen, John H Richburg
Journal: Toxicol Sci
PubMed ID: 38565259
Doi: 10.1093/toxsci/kfae043
Products & Services: Molecular Biology Reagents   
Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins
Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza
Journal: Anticancer Res
PubMed ID: 38821612
Doi: 10.21873/anticanres.17062
Products & Services: Custom DNA/RNA Oligos   
Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases
Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler
Journal: Pathogens
PubMed ID: 38921764
Doi: 10.3390/pathogens13060466
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A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia
Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu
Journal: J Sep Sci
PubMed ID: 38819782
Doi: 10.1002/jssc.202400090
Products & Services: Gene Synthesis   
Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)
Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen
Journal: J Sci Food Agric
PubMed ID: 38855916
Doi: 10.1002/jsfa.13633
Products & Services: Peptide Synthesis   
Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome
Authors: Lamiaa M Mahmoud, Manjul Dutt
Journal: Plant Cell Rep
PubMed ID: 38874819
Doi: 10.1007/s00299-024-03254-3
Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing
Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu
Journal: Nat Biomed Eng
PubMed ID: 38858586
Doi: 10.1038/s41551-024-01227-1
Products & Services: Molecular Biology Reagents   
Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma
Authors: Kalibixiati Aimulajiang, Wen Chu, Shuyi Liao, Zhaohai Wen, Rongdong He, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
Journal: Immun Inflamm Dis
PubMed ID: 38888451
Doi: 10.1002/iid3.1321
Products & Services: Molecular Biology Reagents   
Molecular Mechanism of GmSNE3 Ubiquitin Ligase-Mediated Inhibition of Soybean Nodulation by Halosulfuron Methyl
Authors: Yuanfu Li, Jingsi Qiu, Jingxia Yang, Yihan Li, Hui Zhang, Feng Zhao, Huihua Tan
Journal: J Agric Food Chem
PubMed ID: 38867659
Doi: 10.1021/acs.jafc.4c02621
Products & Services: Catalog Antibody   
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics
Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi
Journal: medrxiv
PubMed ID: 38883797
Doi: 10.1101/2024.06.02.24308281
Products & Services: Catalog Peptides   
Identification of two novel B cell epitopes on E184L protein of African swine fever virus using monoclonal antibodies
Authors: Weldu Tesfagaber, Desong Lan, Wan Wang, Rui Zhao, Li Yin, Mingyang Yang, Yuanmao Zhu, Encheng Sun, Renqiang Liu, Wenjun Lin, Zhigao Bu, Fang Li, Dongming Zhao
Journal: Virus Res
PubMed ID: 38838820
Doi: 10.1016/j.virusres.2024.199412
Products & Services: Gene Synthesis   
Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation
Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu
Journal: J Virol
PubMed ID: 38869285
Doi: 10.1128/jvi.00561-24
Discovery of procyanidin condensed tannins of (-)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2
Authors: Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Journal: Int J Biol Macromol
PubMed ID: 38866269
Doi: 10.1016/j.ijbiomac.2024.133059
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