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OsGRF6-OsYUCCA1/OsWRKY82 Signaling Cascade Upgrade Grain Yield and Bacterial Blight Resistance in Rice

Authors: Huanran Yuan, Mingxing Cheng, Fengfeng Fan , Xingfei Zheng , Ruihua Wang , Fengfeng Si , Xiong Luo, Nengwu Li 1, Shaoqing Li

Journal: Advanced Science

PubMed ID: 38923395

Doi: 10.1002/advs.202407733

Products & Services: Gene Synthesis

Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes

Authors: Yani Arhab , Tatyana V Pestova , Christopher U T Hellen

Journal: Viruses

PubMed ID: 39339889

Doi: 10.3390/v16091413

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A two-pronged nanostrategy of iron metabolism disruption to synergize tumor therapy by triggering the paraptosis-apoptosis hybrid pathway

Authors: Huali Lei , Guanghui Hou , Lin Liu , Zifan Pei , Youdong Chen , Yujie Lu , Nalin Yang , Shumin Sun , Liang Cheng

Journal: ACS Nano

PubMed ID: 39121010

Doi: 10.1021/acsnano.4c06199

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25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism

Authors: Yamei Dang , Yuan Wang , Jing Wei , Hui Zhang , Qiqi Yang , Bin Wang , Jia Li , Chuantao Ye , Yang Chen , Peijun Han , Xiaolei Jin , Jia Wang , Xiaohui Bao , He Liu , Hongwei Ma , Liang Zhang , Linfeng Cheng , Yangchao Dong , Yinlan Bai , Yinghui Li , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: FREE RADICAL BIOLOGY AND MEDICINE

PubMed ID: 39209137

Doi: 10.1016/j.freeradbiomed.2024.08.029

Products & Services: Codon Optimization

Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

Authors: Pheonah Badu , Gabriele Baniulyte , Morgan A Sammons , Cara T Pager

Journal: Virology Journal

PubMed ID: 39212382

Doi: 10.1128/jvi.01055-24

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Reduced Cross-Protective Potential of Omicron Compared to Ancestral SARS-CoV-2 Spike Vaccines Against Potentially Zoonotic Coronaviruses

Authors: Tyler RennerMatthew StuibleBrian CassSylvie PerretJulie GuimondSimon Lord-DufourMichael J. McCluskieYves DurocherBassel Akache

Journal: npj Viruses

Doi: doi.org/10.21203/rs.3.rs-4791122/v1

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

Authors: Jennifer E Gilda, Asrafun Nahar, Dharanibalan Kasiviswanathan, Nadav Tropp, Tamar Gilinski, Tamar Lahav, Dina Alexandrovich, Yael Mandel-Gutfreund, Soyeon Park, Shenhav Shemer

Journal: J Cell Biol

PubMed ID: 38767572

Doi: 10.1083/jcb.202402046

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

Authors: Cheng Zhang , Hong-Ming Ma , Shuai Wu , Jia-Ming Shen , Na Zhang , Yi-Lu Xu , Cheng-Xiao Li , Ping He , Meng-Kai Ge , Xi-Li Chu , Yu-Xue Zhang , Jun-Ke Zheng , Guo-Qiang Chen , Shao-Ming Shen

Journal: Developmental Cell

PubMed ID: 39197453

Doi: 10.1016/j.devcel.2024.08.003

Products & Services: Proteins, Expression, Isolation and Analysis

Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels

Authors: Yuanyue Shan , Mengmeng Zhang , Meiyu Chen , Xinyi Guo , Ying Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39209849

Doi: 10.1038/s41467-024-51800-0.

Products & Services: Proteins, Expression, Isolation and Analysis

Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation

Authors: Nicoletta Cieri 1 2 3, Nidhi Hookeri 1 2 4, Kari Stromhaug 1 2, Liang Li 2, Julia Keating 4, Paula Díaz-Fernández 5, Valle Gómez-García de Soria 6, Jonathan Stevens 7, Raphael Kfuri-Rubens 1 2, Yiren Shao 1 2 4, Kameron A Kooshesh 3, Kaila Powell 1, Helen Ji 1, Gabrielle M Hernandez 2, Jennifer Abelin 2, Susan Klaeger 2 8, Cleo Forman 1 4, Karl R Clauser 2, Siranush Sarkizova 2, David A Braun 1 2 3 9 10, Livius Penter 1 2 3 11, Haesook T Kim 4, William J Lane 3 7, Giacomo Oliveira 1 2 3, Leslie S Kean 3 12, Shuqiang Li 1 13, Kenneth J Livak 1 13, Steven A Carr 2, Derin B Keskin 1 2 3 13 14 15, Cecilia Muñoz-Calleja 5 16, Vincent T Ho 1 3 9, Jerome Ritz 1 3 9, Robert J Soiffer 1 3 9, Donna Neuberg 4, Chip Stewart 2, Gad Getz 2 3 17 18, Catherine J Wu 19 20 21 22

Journal: Nat Biotechnol

PubMed ID: 39169264

Doi: 10.1038/s41587-024-02348-3

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A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity

Authors: Zifan Pei , Nan Jiang , Fei Gong , Weihao Yang , Jiachen Xu , Bin Yu , Nailin Yang , Jie Wu , Huali Lei , Shumin Sun , Longxiao Li , Zhicheng Liu , Caifang Ni , Liang Cheng

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.07.013

Products & Services: Proteins, Expression, Isolation and Analysis

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice

Authors: Yi Ding 1, Qiu-Bing Chen , Hui Xu , Dilare Adi , Yi-Wen Ding , Wen-Jun Luo , Wen-Zhuo Zhu , Jia-Chen Xu , Xiaolu Zhao , Xiong-Jie Shi , Jie Luo , Hao Yin , Xiao-Yi Lu

Journal: Journal of lipid research

PubMed ID: 39173829

Doi: 10.1016/j.jlr.2024.100626

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Channelrhodopsins with distinct chromophores and binding patterns

Authors: Yuanyue Shan , Liping Zhao , Meiyu Chen , Xiao Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39181878

Doi: 10.1038/s41467-024-51811-x

Products & Services: Proteins, Expression, Isolation and Analysis

Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism

Authors: Camila Cimadamore-Werthein , Martin S King , Denis Lacabanne , Eva Pyrihová , Stephany Jaiquel Baron , Edmund Rs Kunji

Journal: EMBO J

PubMed ID: 38937634

Doi: 10.1038/s44318-024-00150-0.

Products & Services: Gene Synthesis

Anattachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection

Authors: Dan Zhou , Rao Cheng , Yanfeng Yao , Gan Zhang , Xin Li , Bingjie Wang , Yong Wang , Feiyang Yu , Shangyu Yang , Hang Liu , Ge Gao , Yun Peng , Miaoyu Chen , Zengqin Deng , Haiyan Zhao

Journal: npj Vaccines

PubMed ID: 39217188

Doi: 10.1038/s41541-024-00954-5

Products & Services: Proteins, Expression, Isolation and Analysis

Cellular N-Myristoyl Transferases Are Required for Mammarenavirus Multiplication

Authors: Haydar Witwit , Carlos Alberto Betancourt , Beatrice Cubitt , Roaa Khafaji , Heinrich Kowalski , Nathaniel Jackson , Chengjin Ye , Luis Martinez-Sobrido , Juan C de la Torre

Journal: Viruses

PubMed ID: 39339839

Doi: 10.3390/v16091362

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hypocretin-1/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model

Authors: Bing Chen , Kangyu Jin , Jingyi Dong , Shangping Cheng , Lingzhuo Kong , Shaohua Hu , Zuobing Chen, Jing Lu

Journal: Advanced Science

PubMed ID: 39119889

Doi: 10.1002/advs.202405354

Products & Services: Proteins, Expression, Isolation and Analysis eBlot ? L1 Fast Wet Transfer System

A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection

Authors: Qishan Wang , Yuehong Wang , Yihao Liu , Kai Yuan , Yixuan Lin , Xian Qian , Hongyan Pei , Liangliang Weng , Kaijian Fan , Yihe Hu , Yiqi Yang

Journal: Carbohydrate Polymers

Doi: 10.1016/j.carbpol.2024.122659

Products & Services: Proteins, Expression, Isolation and Analysis

Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination

Authors: Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia

Journal: Journal of controlled release

PubMed ID: 39153722

Doi: 10.1016/j.jconrel.2024.08.025.

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Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Authors: Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao

Journal: Cell death & disease

PubMed ID: 39097608

Doi: 10.038/s41419-024-06941-x

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamics and implications of anti-drug antibodies against adalimumab using ultra-sensitive and highly drug-tolerant assays

Authors: Xiaoliang Ding, Ling Xue, Mingjun Wang, Shengxiong Zhu, Kouzhu Zhu, Sheng Jiang, Jian Wu, Liyan Miao

Journal: Frontiers in Immunology

PubMed ID: 39238635

Doi: 10.3389/fimmu.2024.1429544

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Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes

Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a

Journal: Analytica Chimica Acta

Doi: 10.1016/j.aca.2024.342932

Products & Services: PCR Cloning and Subcloning

CLASP-mediated competitive binding in protein condensates directs microtubule growth

Authors: Xuanyan Jia , Leishu Lin, Siqi Guo , Lulu Zhou , Gaowei Jin , Jiayuan Dong , Jinman Xiao , Xingqiao Xie , Yiming Li , Sicong He , Zhiyi Wei , Cong Yu

Journal: Nature Communications

PubMed ID: 39095354

Doi: 10.1038/s41467-024-50863-3

Products & Services: Proteins, Expression, Isolation and Analysis

Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Authors: Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39115358

Doi: 10.1002/anie.202411840

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A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Authors: Xuanxiu Ren # 1, Jiawen Sun # 2 3, Wenhua Kuang # 2, Feiyang Yu 1, Bingjie Wang 1, Yong Wang 2 3, Wei Deng 2 3, Zhao Xu 2 3, Shangyu Yang 1, Hualin Wang 2 4, Yangbo Hu 2 4, Zengqin Deng 5 6, Yun-Jia Ning 7 8, Haiyan Zhao

Journal: Nature Communications

PubMed ID: 39147753

Doi: 10.1038/s41467-024-51108-z

Products & Services: Proteins, Expression, Isolation and Analysis

Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

Authors: Shiman Zuo , Yuxin Wang , Hanjing Bao , Zehui Zhang , Nanfei Yang , Meng Jia , Qing Zhang , Ani Jian , Rong Ji , Lidan Zhang , Yan Lu , Yahong Huang , Pingping Shen

Journal: Nature Communications

PubMed ID: 39179603

Doi: doi.org/10.1038/s41467-024-51736-5

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Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy

Authors: Qian Qiu , Jiexin Li , He Ren , Jingyu Zhang , Gengqi Liu , Ruiqi Yang , Boyang Sun , Chen Zhang , Yumiao Zhang

Journal: Small

PubMed ID: 39114869

Doi: 10.1002/smll.202402308

Products & Services: Recombinant Proteins

Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Authors: Sateesh Maddirevula , Mohammad Shagrani , Ae-Ri Ji , Christopher R Horne , Samuel N Young , Lucy J Mather , Mashael Alqahtani , Colin McKerlie , Geoffrey Wood , Paul K Potter , Firdous Abdulwahab , Tarfa AlSheddi , Wendy L van der Woerd , Koen L I van Gassen , Dalal AlBogami , Kishwer Kumar , Ali Syed Muhammad Akhtar , Hiba Binomar , Fowzan S Alkuraya

Journal: GENETICS IN MEDICINE

PubMed ID: 39132680

Doi: 10.1016/j.gim.2024.101231

Products & Services: Peptide Synthesis

Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors

Authors: Shuai Chen , Kaixin Li , Xin Chen , Shan Lei , Jing Lin , Peng Huang

Journal: Science Advances

PubMed ID: 39213344

Doi: 10.1126/sciadv.adn8274

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Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions

Authors: Jiexin Li , Ruiqi Yang , Fuqiang Dong , Qian Qiu , Zhen Jiang , He Ren , Chen Zhang , Gengqi Liu , Jonathan F Lovell , Yumiao Zhang

Journal: ACS Nano

PubMed ID: 39109520

Doi: 10.1021/acsnano.3c12375

Products & Services: Recombinant Proteins

A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Authors: Dimuthu Angage, Jill Chmielewski, Janesha C Maddumage, Eva Hesping, Sabrina Caiazzo, Keng Heng Lai, Lee Ming Yeoh, Joseph Menassa, D Herbert Opi, Callum Cairns, Hamsa Puthalakath, James G Beeson, Marc Kvansakul, Justin A Boddey, Danny W Wilson, Robin F Anders, Michael Foley

Journal: Nat Commun

PubMed ID: 39174515

Doi: 10.1038/s41467-024-50770-7

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OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation

Authors: Xiao-Yu Teng , Ping Hu , Cai-Ming Zhang , Qin-Xin Zhang , Guolin Yang , Yan-Yu Zang , Zhi-Xiong Liu , Guiquan Chen , Yun Stone Shi

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39083419

Doi: 10.1073/pnas.2403652121

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A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

Authors: Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen

Journal: ADVANCED MATERIALS

PubMed ID: 39210649

Doi: 10.1002/adma.202410715

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Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma

Authors: Hong Han , Zenghui Li , Yuqing Feng , He Song , Zhixiong Fang , Dingxiao Zhang , Dan Yuan , Junfeng Shi

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39136347

Doi: doi.org/10.1002/anie.202407381

Products & Services: Recombinant Proteins

The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery

Authors: Zhuang Zhang , Siying Li , Hongda Wang , Yuping Shan

Journal: Analytical Chemistry

PubMed ID: 39096242

Doi: 10.1021/acs.analchem.4c02270

Products & Services: Peptide Synthesis

Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent

Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu

Journal: Bioactive Materials

Doi: doi.org/10.1016/j.bioactmat.2024.07.028

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Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein

Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery

Journal: Protein Sci

PubMed ID: 38864725

Doi: 10.1002/pro.5038

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The strongest protein binder is surprisingly labile

Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez

Journal: Protein Sci

PubMed ID: 38864696

Doi: 10.1002/pro.5030

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Fluorinated Titanium Oxide (TiO2-xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

Authors: Shumin Sun , Xuan Huang , Nailin Yang , Huali Lei , Zifan Pei , Zhihui Han , Lin Liu , Fei Gong , Qiao Yu , Jingrui Li , Youdong Chen , Liang Cheng

Journal: ACS Nano

PubMed ID: 39010657

Doi: 10.1021/acsnano.4c05448

Products & Services: Proteins, Expression, Isolation and Analysis

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Authors: Michael J Peluso, Dylan Ryder, Robert R Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare, Maya Aslam, Walter Koch, Gyula Szabo, Rebecca Hoh, Monika Deswal, Antonio E Rodriguez, Melissa Buitrago, Viva Tai, Uttam Shrestha, Scott Lu, Sarah A Goldberg, Thomas Dalhuisen, Joshua J Vasquez, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Nitasha Kumar, Jeffrey N Martin, Aruna Gambhir, Ma Somsouk, Youngho Seo, Steven G Deeks, Zoltan G Laszik, Henry F VanBrocklin, Timothy J Henrich

Journal: Sci Transl Med

PubMed ID: 38959327

Doi: 10.1126/scitranslmed.adk3295

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Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Authors: Everardo R Rodriguez Rodriguez, Rune Thorbjørn Nordvang, Marcus Petersson, Jakob Kræmmer Haar Rendsvig, Emma Wenzel Arendrup, Monica L Fernández Quintero, Timothy P Jenkins, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Protein Sci

PubMed ID: 38923049

Doi: 10.1002/pro.5035

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering psychrophilic polymerase for nanopore long-read sequencing

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Bioeng Biotechnol

PubMed ID: 39011153

Doi: 10.3389/fbioe.2024.1406722

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Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ

Authors: Souradeep Banerjee, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar

Journal: Protein Sci

PubMed ID: 38864739

Doi: 10.1002/pro.5068

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Improvement and application of vacuum-infiltration system in tomato

Authors: Xinghao Yao, Ayat Taheri, Hang Liu, Yaojie Zhang, Ling Li, Jin Shao, Ke Wu, Qing Miao, Weizhi He, Xinyi Hu, Kexuan Tang

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhae197

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Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax

Authors: Yi Cao 1, Clifford T H Hayashi , Maisa da Silva Araujo , Abhai K Tripathi , Alice Oliveira Andrade , Jansen Fernandes Medeiros , Joseph Vinetz & Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39033079

Doi: 10.1016/j.vaccine.2024.07.041

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Cytochrome b5 diversity in green lineages preceded the evolution of syringyl lignin biosynthesis

Authors: Xianhai Zhao, Yunjun Zhao, Qing-Yin Zeng, Chang-Jun Liu

Journal: Plant Cell

PubMed ID: 38657101

Doi: 10.1093/plcell/koae120

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Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale

Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin

Journal: Cell

PubMed ID: 38936359

Doi: 10.1016/j.cell.2024.05.056

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Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer

Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri

Journal: Mol Cancer Ther

PubMed ID: 38638035

Doi: 10.1158/1535-7163.MCT-23-0766

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Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue

Journal: biorxiv

Doi: 2024.07.26.605286

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Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system

Authors: Danping Zhang 1, Liyang Du 1, Haishan Gao 2 3, Cai Yuan 4, Zhonghui Lin 1

Journal: Nucleic Acids Res

PubMed ID: 38967023

Doi: 10.1093/nar/gkae569

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The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis

Authors: Lei Shi, Changjiang Li, Gaofeng Lv, Xing Li, Wutao Feng, Yujing Bi, Wenhui Wang, Youqun Wang, Lei Zhu, Wenqiang Tang, Ying Fu

Journal: Plant Cell

PubMed ID: 38526222

Doi: 10.1093/plcell/koae086

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Impact of Equilibrative Nucleoside Transporters TgAT1, TgENT1, and TgENT3 on Toxoplasma gondii Infection and Differentiation

Authors: Amber Goerner, Gabriel Messina, Lea Drogalis Beckham, Bruno Martorelli Di Genova

Journal: biorxiv

Doi: doi.org/10.1101/2024.07.10.601519

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Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum

Authors: Zhengjie Wang, Ruili Lv, Chenglin Su, Yan Li, Sizhe Fang, Ruirui Yang, Jiaxuan Zhu, Ruiming Wang, Jun Meng, Yushi Luan

Journal: J Agric Food Chem

PubMed ID: 38994823

Doi: 10.1021/acs.jafc.4c03588

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Comparative biochemistry of PET hydrolase-carbohydrate-binding module fusion enzymes on a variety of PET substrates

Authors: Andrew Philip Rennison , Andreas Prestel , Peter Westh , Marie Sofie Møller

Journal: Enzyme and Microbial Technology

PubMed ID: 39047349

Doi: 10.1016/j.enzmictec.2024.110479

Products & Services: Gene Synthesis Mutagenesis Services

Mechanism of ceramide synthase inhibition by fumonisin B1

Authors: Zike Zhang 1 2 4, Qi Fang 1 2 4, Tian Xie 1 2, Xin Gong

Journal: Structure

Doi: 10.1016/j.str.2024.06.002

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

Authors: Moisés Alejandro Alejo Hernandez , Katia Pamela Villavicencio Sánchez , Rosendo Sánchez Morales , Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez , Eddie Guillermo Sanchez-Rueda , Yanet Teresa-Cruz , Brian Choi, Armando Hernández Garcia , Alba Romero-Rodríguez, Oscar Juárez , Siseth Martínez-Caballero , Mario Figueroa , Corina-Diana Ceapă

Journal: Beilstein Journal of Organic Chemistry

PubMed ID: 39109298

Doi: 10.3762/bjoc.20.159

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Acceptors stability modulates the efficiency of post-translational protein N-glycosylation

Authors: Paula M Couto, Carlos M A Guardia, Facundo L Couto, Carlos A Labriola, María S Labanda, Julio J Caramelo

Journal: FASEB J

PubMed ID: 38934375

Doi: 10.1096/fj.202302267R

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Integration of validated functional evidence to support the pathogenicity of KCNH2 variants

Authors: Reema W Aljassar, Qianyi Shen, Buthaina Albash, Jamie I Vandenberg, Mohammad A Ebrahim, Chai-Ann Ng

Journal: Genet Med Open

PubMed ID: 39669639

Doi: 10.1016/j.gimo.2024.101868

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Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner

Authors: Lin-Chao Yu, Rui He, Dao-Xin Wang, Di Qi

Journal: Am J Respir Cell Mol Biol

PubMed ID: 38574235

Doi: 10.1165/rcmb.2024-0017OC

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METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA

Authors: Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu

Journal: Hereditas

PubMed ID: 38956710

Doi: 10.1186/s41065-024-00317-z

Products & Services: Mutant Libraries

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Authors: Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn

Journal: J Mol Cell Biol

PubMed ID: 38253401

Doi: 10.1093/jmcb/mjae003

Products & Services: Mutant Libraries

Screening L-Lysine-Overproducing Escherichia coli Using Artificial Rare Codons and a Rare Codon-Rich Marker

Authors: Shen Li , Tianhao Xu , Xinru Meng , Yujuan Yan , Ying Zhou , Lei Duan , Yulong Tang , Li Zhu & Litao Sun

Journal: Nucleic Acids Research

PubMed ID: 38989624

Doi: doi.org/10.3390/

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DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants

Authors: Bingbing Yu , Yifan Chen , Yan Yan , Xueling Lu , Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38979568

Doi: 10.1093/nar/gkae593

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Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Authors: Yan Wang , Jing Zhang , Ying Liu , Xiao Yue , Kun Han , Zhichao Kong , Yuanmin Dong , Zhenmei Yang , Zhipeng Fu , Chunwei Tang , Chongdeng Shi , Xiaotian Zhao , Maosen Han , Zhibin Wang , Yulin Zhang , Chen Chen , Anning Li , Peng Sun , Danqing Zhu , Kun Zhao , Xinyi Jiang

Journal: Sci Adv

PubMed ID: 38865465

Doi: 10.1126/sciadv.ado4791

Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices

Authors: Yuxiang Liu, Ruixuan Wang, Qimingxing Chen, Yan Chang, Qi Chen, Kodai Fukumoto, Bingxun Wang, Jianchen Yu, Changfeng Luo, Jiayuan Ma, Xiaoxia Chen, Yuko Murayama, Kenichi Umeda, Noriyuki Kodera, Yoshie Harada, Shun-Ichi Sekine, Jianfeng Li, Hisashi Tadakuma

Journal: NANO LETTERS

PubMed ID: 38920331

Doi: 10.1021/acs.nanolett.4c02104

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A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7

Authors: Christian J Muñoz Sosa , Christopher Lenz , Anton Hamann , Frederic Farges , Johannes Dopfer , Andreas Krämer , Veronika Cherkashyna , Andrey Tarnovskiy , Yurii S Moroz , Ewgenij Proschak , Václav Němec , Susanne Müller , Krishna Saxena , Stefan Knapp

Journal: ACS Chem Biol

PubMed ID: 38934237

Doi: 10.1021/acschembio.4c00301

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Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals

Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang

Journal: Small Methods

PubMed ID: 38864527

Doi: 10.1002/smtd.202400664

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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

Authors: Huasong Ai , Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol

PubMed ID: 38918638

Doi: doi.org/10.1038/s41594-024-01342-2

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The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart

Authors: Elena Tsisanova, Muriel Nobles, Sonia Sebastian, Keat-Eng Ng, Alison Thomas, Lee Scott Weinstein, Patricia B Munroe, Andrew Tinker

Journal: J Biol Chem

PubMed ID: 38879012

Doi: 10.1016/j.jbc.2024.107470

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Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins

Authors: Piotr Kolesiński, Matthew McGowan, Anne Botteaux, Pierre R Smeesters, Partho Ghosh

Journal: J Biol Chem

PubMed ID: 38879009

Doi: 10.1016/j.jbc.2024.107478

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Synthetic genomes unveil the effects of synonymous recoding

Authors: Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Dawn Chen, Jenny Ahn, Owen Spencer, Venkat Ayalavarapu, Angela Tarver, Miranda Harmon-Smith, Matthew Hamilton, Ian Blaby, Yasuo Yoshikuni, Behnoush Hajian, Adeline Jin, Balint Kintses, Monika Szamel, Viktoria Seregi, Yue Shen, Zilong Li, George M Church

Journal: biorxiv

PubMed ID: 38915524

Doi: 10.1101/2024.06.16.599206

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The Human Genetic Differences in the Outcomes of mRNA Vaccination against COVID-19: A Prospective Cohort Study

Authors: Ha-Eun Ryu, Jihyun Yoon, Ja-Eun Choi, Seok-Jae Heo, Kyung-Won Hong, Dong-Hyuk Jung

Journal: Vaccines (Basel)

PubMed ID: 38932355

Doi: 10.3390/vaccines12060626

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PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation

Authors: Antonio Ruiz-Albor, Belén Chaves-Arquero, Inés Martín-Barros, Alejandra Guerra-Castellano, Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Nekane Merino, Mariola Ferreras-Gutiérrez, Edurne Berra, Irene Díaz-Moreno, Francisco J Blanco

Journal: Int J Biol Macromol

PubMed ID: 38880460

Doi: 10.1016/j.ijbiomac.2024.133187

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Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline

Authors: Brenna Norton-Baker, Mackenzie C R Denton, Natasha P Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P Gauthier, Gregg T Beckham

Journal: Sci Rep

PubMed ID: 38914665

Doi: 10.1038/s41598-024-64938-0

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Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression

Authors: Jun-Sheng Ni, Si-Yuan Fu, Zong-Yan Wang, Wen-Bin Ding, Jian Huang, Xing-Gang Guo, Fang-Ming Gu

Journal: J Gene Med

PubMed ID: 38860366

Doi: 10.1002/jgm.3693

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Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14

Authors: Drayson Graves, Nikolas Akkerman, Lauren Fulham, Rafe Helwer, Peter Pelka

Journal: MBio

PubMed ID: 38940561

Doi: 10.1128/mbio.01038-24

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TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

Authors: Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan

Journal: biorxiv

PubMed ID: 38895352

Doi: 10.1101/2024.06.04.597282

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In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade

Authors: Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu

Journal: Immunol Lett

PubMed ID: 38925442

Doi: 10.1016/j.imlet.2024.106887

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RcOST1L phosphorylates RcPIF4 for proteasomal degradation to promote flowering in rose

Authors: Jingjing Sun, Hongchi Liu, Weinan Wang, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jun Lu, Jinyi Liu, Changquan Wang

Journal: New Phytol

PubMed ID: 38849320

Doi: 10.1111/nph.19885

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Characterization of Two Glycoside Hydrolases of Family GH13 and GH57, Present in a Polysaccharide Utilization Locus (PUL) of sp SGAir0037

Authors: Hilda Hubertha Maria Bax, Edita Jurak

Journal: Molecules

PubMed ID: 38930854

Doi: 10.3390/molecules29122788

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Metal binding feature of copper‒induced metallothionein from freshwater crab Sinopotamon henanense reveals its Cu‒thionein character

Authors: Huizhen Yang, Ziyan Zhao, Hongquan Li, Lan Wang

Journal: Protein Expr Purif

PubMed ID: 38830441

Doi: 10.1016/j.pep.2024.106519

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Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing

Authors: Yaoqi Sun, Bing Xiong, Xueqian Shuai, Jiale Li, Chunyan Wang, Jing Guo, Zhongping Cheng, Shupeng Liu

Journal: Mol Med

PubMed ID: 38867190

Doi: 10.1186/s10020-024-00849-0

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Surface functionalization of virus-like particles via bioorthogonal click reactions for enhanced cell-specific targeting

Authors: Chavee Laomeephol, Supannikar Tawinwung, Koramit Suppipat, Wanatchaporn Arunmanee, Qian Wang, Jittima Amie Luckanagul

Journal: Int J Pharm

PubMed ID: 38866085

Doi: 10.1016/j.ijpharm.2024.124332

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Developing deprotectase biocatalysts for synthesis

Authors: Lisa Kennedy, Mariyah Sajjad, Michael A Herrera, Peter Szieber, Natasza Rybacka, Yinan Zhao, Craig Steven, Zainab Alghamdi, Ivan Zlatkov, Julie Hagen, Chloe Lauder, Natalie Rudolfova, Magdalena Abramiuk, Karolina Bolimowska, Daniel Joynt, Angelica Lucero, Gustavo Perez Ortiz, Annamaria Lilienkampf, Alison N Hulme, Dominic J Campopiano

Journal: Faraday Discuss

PubMed ID: 38856717

Doi: 10.1039/d4fd00016a

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Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

Authors: Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang

Journal: Mol Med

PubMed ID: 38867145

Doi: 10.1186/s10020-024-00854-3

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MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Authors: Yen-Nien Liu, Wei-Yu Chen, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Phan Vu Thuy Dung, Zi-Qing Chen, Wei-Jiunn Lee, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen

Journal: Sci Signal

PubMed ID: 38861615

Doi: 10.1126/scisignal.adc9142

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Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis

Authors: Elisa Perez-Moreno, Tomás Toledo, Pascale Campusano, Sebastián Zuñiga, Lorena Azócar, Teo Feuerhake, Gonzalo P Méndez, Mariana Labarca, Francisca Pérez-Molina, Adely de la Peña, Cristian Herrera-Cid, Pamela Ehrenfeld, Alejandro S Godoy, Alfonso González, Andrea Soza

Journal: Biomed Pharmacother

PubMed ID: 38936192

Doi: 10.1016/j.biopha.2024.116923

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Unveiling of the Co-Infection of Peste des Petits Ruminants Virus and Caprine Enterovirus in Goat Herds with Severe Diarrhea in China

Authors: Qun Zhang, Xuebo Zheng, Fan Zhang, Xuyuan Cui, Naitian Yan, Junying Hu, Yidi Guo, Xinping Wang

Journal: Viruses

PubMed ID: 38932277

Doi: 10.3390/v16060986

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Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth

Authors: Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer

Journal: Cell Death Differ

PubMed ID: 38858548

Doi: 10.1038/s41418-024-01319-0

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Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody

Authors: Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-Anong Juntit, Umpa Yasamut, Nuchjira Takheaw, Watchara Kasinrerk, Phenphichar Wanachantararak, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Nutjeera Intasai, Chatchai Tayapiwatana

Journal: Int J Mol Sci

PubMed ID: 38928332

Doi: 10.3390/ijms25126626

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A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Authors: Desmond Richmond-Buccola, Samuel J Hobbs, Jasmine M Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S Y Lee, Philip J Kranzusch

Journal: Cell Host Microbe

PubMed ID: 38917809

Doi: 10.1016/j.chom.2024.05.021

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Dissecting the dynamics of SARS-CoV-2 reinfections in blood donors with pauci- or asymptomatic COVID-19 disease course at initial infection

Authors: Alexandra Domnica Hoeggerl, Verena Nunhofer, Lisa Weidner, Wanda Lauth, Georg Zimmermann, Natalie Badstuber, Christoph Grabmer, Orkan Kartal, Christof Jungbauer, Heidrun Neureiter, Nina Held, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger

Journal: Infect Dis (Lond)

PubMed ID: 38869944

Doi: 10.1080/23744235.2024.2367112

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Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset

Authors: Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudio Franceschi, Ivan Doykov, Justyna Śpiewak, Héloїse Vinette, Claudia Trenkwalder, Wendy E Heywood, Kevin Mills, Brit Mollenhauer

Journal: Nat Commun

PubMed ID: 38890280

Doi: 10.1038/s41467-024-48961-3

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SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution

Authors: Yao Yao, Zhiwei Zhou, Xiaoling Wang, Zhirui Liu, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue, Shuquan Rao

Journal: Cell Genom

PubMed ID: 38889719

Doi: 10.1016/j.xgen.2024.100583

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

Authors: Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens

Journal: Nat Struct Mol Biol

PubMed ID: 38918639

Doi: 10.1038/s41594-024-01338-y

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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Authors: Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde

Journal: Nat Metab

PubMed ID: 38871982

Doi: 10.1038/s42255-024-01061-4

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GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening

Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner

Journal: ACS Omega

PubMed ID: 38947828

Doi: 10.1021/acsomega.4c01583

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Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu

Journal: BMC Plant Biol

PubMed ID: 38851686

Doi: 10.1186/s12870-024-05189-z

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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p

Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie

Journal: Genesis

PubMed ID: 38764323

Doi: 10.1002/dvg.23599

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N-terminal cysteine acetylation and oxidation patterns may define protein stability

Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Journal: Nat Commun

PubMed ID: 38918375

Doi: 10.1038/s41467-024-49489-2

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