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A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome

Authors: Soo Jung Lee , Xiaojie Zhang , Gang Xu , Jimo Borjigin , Michael M Wang

Journal: J Biol Chem .

PubMed ID: 36470429

Doi: 10.1016/j.jbc.2022.102772

Products & Services: Peptide Synthesis Protein and Antibody Isolation

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

Authors: Saskia Meyer , Isaac Blaas , Ravi Chand Bollineni , Marina Delic-Sarac , Trung T Tran , Cathrine Knetter , Ke-Zheng Dai , Torfinn Støve Madssen , John T Vaage , Alice Gustavsen , Weiwen Yang , Lise Sofie Haug Nissen-Meyer , Karolos Douvlataniotis , Maarja Laos , Morten Milek Nielsen , Bernd Thiede , Arne Søraas , Fridtjof Lund-Johansen , Even H Rustad, Johanna Olweus

Journal: Cell Rep .

PubMed ID: 36656713

Doi: 10.1016/j.celrep.2023.111995

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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Authors: Jia Duan , Peiyu Xu , Huibing Zhang , Xiaodong Luan , Jiaqi Yang, Xinheng He , Chunyou Mao , Dan-Dan Shen , Yujie Ji , Xi Cheng , Hualiang Jiang , Yi Jiang , Shuyang Zhang , Yan Zhang , H Eric Xu

Journal: Nat Commun .

PubMed ID: 36720854

Doi: 10.1038/s41467-023-36170-3

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Wheat yellow mosaic virus NIb targets TaVTC2 to elicit broad-spectrum pathogen resistance in wheat.

Authors: Zhang Tianye, Hu Haichao, Wang Ziqiong, Feng Tianyou, Yu Lu, Jie Zhang, Gao Wenqing, Zhou Yilin, Meihao Sun, Peng Liu, Zhong Kaili, Chen ZhiHui, Jianping Chen, Wei Li, Jian Yang

Journal: Plant Biotechnology Journal

PubMed ID: 36715229

Doi: 10.1111/pbi.14019

Products & Services: Protein Electrophoresis and Western

Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe

Authors: Chuntong Li, Tian Wang, Lujun Liang, Guochao Chu, Jiachen Zhang, Wei He, Lei Liu, Jinghong Li

Journal: Science China. Chemistry

PubMed ID: 36684644

Doi: 10.1007/s11426-022-1455-x

Products & Services: Gene Synthesis Protein Electrophoresis and Western

lectrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48

Authors: Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher

Journal: The journal of physical chemistry. B

PubMed ID: 36542812

Doi: 10.1021/acs.jpcb.2c06677

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Cryo-EM structures of orphan GPR21 signaling complexes

Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu

Journal: Nature Communications

PubMed ID: 36639690

Doi: 10.1038/s41467-023-35882-w

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Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang

Journal: Hum Cell

PubMed ID: 36627546

Doi: 10.1007/s13577-022-00851-w

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PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja

Journal: Cell Death Dis

PubMed ID: 36627281

Doi: 10.1038/s41419-022-05539-5

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Pold4 is dispensable for mouse development, DNA replication and DNA repair

Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou

Journal: Gene

PubMed ID: 36356905

Doi: 10.1016/j.gene.2022.147029

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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Authors: Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y Tsao, Christoph T Ellebrecht, Sami L Khella, David P Richman, Kevin C O'Connor, Uri Herzberg, Gwendolyn K Binder, Michael C Milone, Samik Basu, Aimee S Payne

Journal: Nat Biotechnol

PubMed ID: 36658341

Doi: 10.1038/s41587-022-01637-z

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A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology

Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian

Journal: Virology

PubMed ID: 36623351

Doi: 10.1016/j.virol.2023.01.001

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CRISPR mediated transactivation in the human disease vector Aedes aegypti

Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari

Journal: PLoS Pathog

PubMed ID: 36656895

Doi: 10.1371/journal.ppat.1010842

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Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida

Journal: Front Cell Dev Biol

PubMed ID: 36760361

Doi: 10.3389/fcell.2023.1050323

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Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis

Authors: Hongyang Shi, Yuqiang Ji, Yonghong Zhang, Yu Wang, Wei Li

Journal: Environ Toxicol

PubMed ID: 36637163

Doi: 10.1002/tox.23736

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Loss-of-function KCa2.2 mutations abolish channel activity

Authors: Young-Woo Nam , Mohammad Asikur Rahman , Grace Yang , Razan Orfali , Meng Cui , Miao Zhang

Journal: Am J Physiol Cell Physiol

PubMed ID: 36717104

Doi: 10.1152/ajpcell.00584.2022

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Expression and kinetic characterization of PYCR3 Kaylen

Authors: Kaylen R Meeks , John J Tanner

Journal: Arch Biochem Biophys

PubMed ID: 36414121

Doi: 10.1016/j.abb.2022.109468

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Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats

Authors: NicolasG.Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim , RobertT. Kennedy, GeorgeA. Mashour, Michael M. Wang & Jimo Borjigin

Journal: Scientific REPORTS

PubMed ID: 36609666

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SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis

Authors: Mohammad G Mohammad, Naglaa S Ashmawy, Ahmed M Al-Rawi, Ameera Abu-Qiyas, Alshaimaa M Hamoda, Rania Hamdy, Salam Dakalbab, Shahad Arikat, Dana Salahat, Mohamed Madkour, Sameh S M Soliman

Journal: PLoS ONE

PubMed ID: 36656874

Doi: 10.1371/journal.pone.0280592

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The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae

Authors: Giovanni Covaleda-Cortés, Ariel Mechaly, Terry Brissac, Heike Baehre, Laura Devaux, Patrick England, Bertrand Raynal, Sylviane Hoos, Myriam Gominet, Arnaud Firon, Patrick Trieu-Cuot, Pierre Alexandre Kaminski

Journal: FEBS J

PubMed ID: 36629470

Doi: 10.1111/febs.16724

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Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

Authors: Stephen J Staklinski, Mario C Chang, Rebecca C Ahrens-Nicklas, Shagun Kaur, Arianna K Stefanatos, Elizabeth E Dudenhausen, Matthew E Merritt, Michael S Kilberg

Journal: JIMD Rep

PubMed ID: 36873094

Doi: 10.1002/jmd2.12356

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Maltose-Enhanced Exopolysaccharide Synthesis of through CRP-like Protein

Authors: Fanqiang Meng, Yunbin Lyu, Xiaoyu Chen, Fengxia Lu, Haizhen Zhao, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: J Agric Food Chem

PubMed ID: 36602107

Doi: 10.1021/acs.jafc.2c07880

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Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Authors: Mikayla Hoad, Emily M Cross, Camilla M Donnelly, Subir Sarker, Justin A Roby, Jade K Forwood

Journal: Viruses

PubMed ID: 36851528

Doi: 10.3390/v15020315

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Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies

Authors: Lian C T Shoute, Gaser N Abdelrasoul, Yuhao Ma, Pedro A Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N Kanji, Shawn Babiuk, Jie Chen

Journal: Microsyst Nanoeng

PubMed ID: 36597510

Doi: 10.1038/s41378-022-00460-5

Products & Services: PCR Cloning and Subcloning

Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro

Authors: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 36724628

Doi: 10.1016/j.jphotobiol.2023.112654

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Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li

Journal: J Am Chem Soc.

PubMed ID: 36542856

Doi: 10.1021/jacs.2c10177

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Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus

Authors: Laura Sandra Lello, Agneta Miilimäe, Liubov Cherkashchenko, Ailar Omler, Rachel Skilton, Rachel Ireland, David Ulaeto, Andres Merits

Journal: J Virol

PubMed ID: 36533950

Doi: 10.1128/jvi.01368-22

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RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)

Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu

Journal: J Exp Bot

PubMed ID: 36239471

Doi: 10.1093/jxb/erac406

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Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)

Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong

Journal: J Anim Sci

PubMed ID: 37186172

Doi: 10.1093/jas/skad125

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Magnaporthe oryzae pathotype Triticum (MoT) can act as a heterologous expression system for fungal effectors with high transcript abundance in wheat

Authors: Cassandra Jensen, Diane G O Saunders

Journal: Sci Rep

PubMed ID: 36596834

Doi: 10.1038/s41598-022-27030-z

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Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W

Authors: Jia Zang, Yulin Chen, Chao Liu, Linzhen Hu, Hongxia Zhao, Wenlong Ding, Ying Yuan, Shixian Lin

Journal: Nat Struct Mol Biol

PubMed ID: 36593310

Doi: 10.1038/s41594-022-00866-9

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RACK1 release from the Ribosome Couples Translational Regulation with Starving Signaling and Possibly Depends on Phosphorylation of Key Serine and Threonine Residues

Authors: Maria Kiratzis, Giancarlo Lai, Piera Calamita, Marilena Mancino, Marcello Iriti, Nicola Manfrini, Simone Gallo

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 37213164

Doi: 10.14715/cmb/2022.69.1.2

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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q133 microdeletion syndrome

Authors: Brianna K Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W Doble, Laurence Faivre, Antonio Vitobello, Stephen W Scherer, Yu Lu, Peter Penzes, Karun K Singh

Journal: Mol Psychiatry

PubMed ID: 36604605

Doi: 10.1038/s41380-022-01937-5

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Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2

Authors: Xuebo Li, Fan Wu

Journal: Cell Death Discov

PubMed ID: 36609437

Doi: 10.1038/s41420-022-01283-z

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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli

Journal: Nat Commun

PubMed ID: 36709207

Doi: 10.1038/s41467-023-36081-3

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YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma

Authors: Yuting Gao, Qing Peng, Shenghao Li, Kangning Zheng, Yi Gong, Yu Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi

Journal: Exp Cell Res

PubMed ID: 36693491

Doi: 10.1016/j.yexcr.2023.113486

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Author Correction: Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-Dong Luan, Bin-Xian Chen, Wei-Juan Shang, Wan-Chao Yin, Ye Jin, Lei-Ke Zhang, H Eric Xu, Shu-Yang Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35948753

Doi: 10.1038/s41401-022-00964-w

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An iterative gene-editing strategy broadens eIF4E1 genetic diversity in Solanum lycopersicum and generates resistance to multiple potyvirus isolates

Authors: Kyoka Kuroiwa, Benoit Danilo, Laura Perrot, Christina Thenault, Florian Veillet, Fabien Delacote, Philippe Duchateau, Fabien Nogué, Marianne Mazier, Jean-Luc Gallois

Journal: Plant Biotechnol J

PubMed ID: 36715107

Doi: 10.1111/pbi.14003

Products & Services: Protein and Antibody Isolation

The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

Authors: Xue Yang, Miguel I Cruz, Elizabeth V Nguyen, Cheng Huang, Ralf B Schittenhelm, Jennii Luu, Karla J Cowley, Sung-Young Shin, Lan K Nguyen, Terry C C Lim Kam Sian, Kimberley C Clark, Kaylene J Simpson, Xiuquan Ma, Roger J Daly

Journal: Oncogene

PubMed ID: 36693952

Doi: 10.1038/s41388-023-02594-w

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Impacts of delta and omicron variants on inactivated SARS-CoV-2 vaccine-induced T cell responses in patients with autoimmune diseases and healthy controls

Authors: Shuyi Wang, Jin Li, Shuang Wang, Yujin Ye, Mengyuan Li, Yihao Liu, Binfeng Chen, Yimei Lai, Liubing Li, Lili Zhuang, Sui Peng, Niansheng Yang, Hui Zhang, Haipeng Xiao

Journal: Clin Transl Med

PubMed ID: 36639826

Doi: 10.1002/ctm2.1171

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In Vitro and In Silico Studies of Kinase Inhibitor of MAPK3 Protein to Determine Leishmania martiniquensis Treatment

Authors: Thitinan Aiebchun, Natchaya Rasri, Duangnapa Kiriwan, Suradej Siripattanapipong, Kiattawee Choowongkomon

Journal: Acta Parasitol

PubMed ID: 36637694

Doi: 10.1007/s11686-023-00659-0

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Booster shot of inactivated SARS-CoV-2 vaccine induces potent immune responses in people living with HIV

Authors: Haoting Zhan, Huixia Gao, Yongmei Liu, Xihong Zhang, Haolong Li, Xiaomeng Li, Lijing Wang, Chen Li, Beilei Li, Yuling Wang, Erhei Dai, Yongzhe Li

Journal: J Med Virol

PubMed ID: 36571267

Doi: 10.1002/jmv.28428

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Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

Authors: John P Finnigan, Jenna H Newman, Yury Patskovsky, Larysa Patskovska, Andrew S Ishizuka, Geoffrey M Lynn, Robert A Seder, Michelle Krogsgaard, Nina Bhardwaj

Journal: Res Sq

PubMed ID: 36778273

Doi: 10.21203/rs.3.rs-2531184/v1

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Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1

Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker

Journal: ACS Omega .

PubMed ID: 36713721

Doi: 10.1021/acsomega.2c07788

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Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

Authors: Rafael Galupa, Gilberto Alvarez-Canale, Noa Ottilie Borst, Timothy Fuqua, Lautaro Gandara, Natalia Misunou, Kerstin Richter, Mariana R P Alves, Esther Karumbi, Melinda Liu Perkins, Tin Kocjan, Christine A Rushlow, Justin Crocker

Journal: Dev Cell

PubMed ID: 36626871

Doi: 10.1016/j.devcel.2022.12.003

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S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction

Authors: Liam Butler , Carolina Locatelli , Despoina Allagioti , Irina Lousa , Kimon Lemonidis , Nicholas C O Tomkinson , Christine Salaun , Luke H Chamberlain

Journal: J Biol Chem

PubMed ID: 36442513

Doi: 10.1016/j.jbc.2022.102754

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Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium

Authors: Heather M Callaway, Kathryn M Hastie, Sharon L Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S Moses Dennison, Kan Li, Michael D Alpert, Charles C Bailey, Sharon Benzeno, Jody L Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D Crompton, Vincent Dussupt, Kevin C Entzminger, Yassine Ezzyat, Jonathan K Fleming, Nick Geukens, Amy E Gilbert, Yongjun Guan, Xiaojian Han, Christopher J Harvey, Julia M Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K Kolls, Shelly J Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C J Okumura, Benjamin E R Rubin, Aaron K Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M Trimarchi, Dhruvkumar P Upadhyay, Yingming Wang, Lei Yu, Tom Z Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire

Journal: Cell Rep

PubMed ID: 36681898

Doi: 10.1016/j.celrep.2023.112014

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Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Authors: Wencheng Zhu, Huiying Chu, Yajuan Zhang, Tianhang Luo, Hua Yu, Hongwen Zhu, Ye Liu, Hong Gao, Yun Zhao, Quanlin Li, Xiongjun Wang, Guohui Li, Weiwei Yang

Journal: Cell Res

PubMed ID: 36646759

Doi: 10.1038/s41422-022-00773-0

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Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo

Authors: Farzana Tuli, Patricia M Kane

Journal: Mol Biol Cell

PubMed ID: 36598799

Doi: 10.1091/mbc.E22-07-0265

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A covalent opsonization approach to enhance synthetic immunity against viral escape variants

Authors: Eden Kapcan, Anthony F Rullo

Journal: Cell Rep Phys Sci

PubMed ID: 36741337

Doi: 10.1016/j.xcrp.2023.101258

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