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In Vitro and In Silico Studies of Kinase Inhibitor of MAPK3 Protein to Determine Leishmania martiniquensis Treatment

Authors: Thitinan Aiebchun, Natchaya Rasri, Duangnapa Kiriwan, Suradej Siripattanapipong, Kiattawee Choowongkomon

Journal: Acta Parasitol

PubMed ID: 36637694

Doi: 10.1007/s11686-023-00659-0

Products & Services: Protein and Antibody Isolation

Booster shot of inactivated SARS-CoV-2 vaccine induces potent immune responses in people living with HIV

Authors: Haoting Zhan, Huixia Gao, Yongmei Liu, Xihong Zhang, Haolong Li, Xiaomeng Li, Lijing Wang, Chen Li, Beilei Li, Yuling Wang, Erhei Dai, Yongzhe Li

Journal: J Med Virol

PubMed ID: 36571267

Doi: 10.1002/jmv.28428

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Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

Authors: John P Finnigan, Jenna H Newman, Yury Patskovsky, Larysa Patskovska, Andrew S Ishizuka, Geoffrey M Lynn, Robert A Seder, Michelle Krogsgaard, Nina Bhardwaj

Journal: Res Sq

PubMed ID: 36778273

Doi: 10.21203/rs.3.rs-2531184/v1

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Alleviation of Hepatic Steatosis by 4-azidophlorizin via the Degradation of Geranylgeranyl Diphosphate Synthase by the Ubiquitin-Proteasome Pathway in Vivo and in Vitro

Authors: Juan Ye, Yaling Qi, Jiao Chen, Shihu Zhang, Boyuan Liu, Yinjuan Zhao, Xianwen Yuan, Qi Cheng, Yang Yang, Furong Zhang, Hongliang Gao, Haoran Wang, Jing Wu, Feng Zhu, Chaojun Li, Peng Cao, Bin Xue

Journal: Adv Biol (Weinh)

PubMed ID: 36599632

Doi: 10.1002/adbi.202200150

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Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

Authors: Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S Cooperman, Joanna Rorbach

Journal: Nat Commun

PubMed ID: 36596788

Doi: 10.1038/s41467-022-35684-6

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New Synthetic Operon Vectors for Expressing Multiple Proteins in the Chloroplast

Authors: Jihye Yeon, Stephen M Miller, Wipawee Dejtisakdi

Journal: Genes (Basel)

PubMed ID: 36833295

Doi: 10.3390/genes14020368

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Epitope identification for p53R273C mutant

Authors: Jian Zhang, Minglu Liu, Yin Chen, Zishan Zhou, Ping Wang, Yang Yu, Shunchang Jiao

Journal: Immun Inflamm Dis

PubMed ID: 36705409

Doi: 10.1002/iid3.752

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A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep

Authors: Bianca Elena Bratuleanu, Cristian Raileanu, Delphine Chrétien, Pablo Guardado-Calvo, Thomas Bigot, Gheorghe Savuta, Sarah Temmam, Marc Eloit

Journal: Microorganisms

PubMed ID: 36677501

Doi: 10.3390/microorganisms11010209

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Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice

Authors: Emily D Morales, Yongping Yue, Thais B Watkins, Jin Han, Xiufang Pan, Aaron M Gibson, Bryan Hu, Omar Brito-Estrada, Gang Yao, Catherine A Makarewich, Gopal J Babu, Dongsheng Duan

Journal: J Am Heart Assoc

PubMed ID: 36695318

Doi: 10.1161/JAHA.122.027480

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Delineation of the CYP505E subfamily of fungal self-sufficient in-chain hydroxylating cytochrome P450 monooxygenases

Authors: Martha Sophia Smit, Mpeyake Jacob Maseme, Jacqueline van Marwijk, Jasmin Cara Aschenbrenner, Diederik Johannes Opperman

Journal: Appl Microbiol Biotechnol

PubMed ID: 36607403

Doi: 10.1007/s00253-022-12329-8

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Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex

Authors: Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, Alessandra Esposito, Jlenia Monfregola, Lukas A Huber, Andrea Ballabio, James H Hurley

Journal: Nature

PubMed ID: 36697823

Doi: 10.1038/s41586-022-05652-7

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Identification of gluten T cell epitopes driving celiac disease

Authors: Markéta Chlubnová, Asbjørn O Christophersen, Geir Kjetil F Sandve, Knut E A Lundin, Jørgen Jahnsen, Shiva Dahal-Koirala, Ludvig M Sollid

Journal: Sci Adv

PubMed ID: 36696493

Doi: 10.1126/sciadv.ade5800

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A covalent opsonization approach to enhance synthetic immunity against viral escape variants

Authors: Eden Kapcan, Anthony F Rullo

Journal: Cell Rep Phys Sci

PubMed ID: 36741337

Doi: 10.1016/j.xcrp.2023.101258

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Ensemble-based, high-throughput virtual screening of potential inhibitor targeting putative farnesol dehydrogenase of Metisa plana (Lepidoptera: Psychidae)

Authors: Anis Nadyra Zifruddin, Mohamad Ariff Mohamad Yusoff, Nur Syatila Abd Ghani, Nor Azlan Nor Muhammad, Kok Wai Lam, Maizom Hassan

Journal: Comput Biol Chem

PubMed ID: 36645937

Doi: 10.1016/j.compbiolchem.2023.107811

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S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction

Authors: Liam Butler , Carolina Locatelli , Despoina Allagioti , Irina Lousa , Kimon Lemonidis , Nicholas C O Tomkinson , Christine Salaun , Luke H Chamberlain

Journal: J Biol Chem

PubMed ID: 36442513

Doi: 10.1016/j.jbc.2022.102754

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Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1

Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker

Journal: ACS Omega .

PubMed ID: 36713721

Doi: 10.1021/acsomega.2c07788

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Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Authors: Wencheng Zhu, Huiying Chu, Yajuan Zhang, Tianhang Luo, Hua Yu, Hongwen Zhu, Ye Liu, Hong Gao, Yun Zhao, Quanlin Li, Xiongjun Wang, Guohui Li, Weiwei Yang

Journal: Cell Res

PubMed ID: 36646759

Doi: 10.1038/s41422-022-00773-0

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Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo

Authors: Farzana Tuli, Patricia M Kane

Journal: Mol Biol Cell

PubMed ID: 36598799

Doi: 10.1091/mbc.E22-07-0265

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Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium

Authors: Heather M Callaway, Kathryn M Hastie, Sharon L Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S Moses Dennison, Kan Li, Michael D Alpert, Charles C Bailey, Sharon Benzeno, Jody L Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D Crompton, Vincent Dussupt, Kevin C Entzminger, Yassine Ezzyat, Jonathan K Fleming, Nick Geukens, Amy E Gilbert, Yongjun Guan, Xiaojian Han, Christopher J Harvey, Julia M Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K Kolls, Shelly J Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C J Okumura, Benjamin E R Rubin, Aaron K Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M Trimarchi, Dhruvkumar P Upadhyay, Yingming Wang, Lei Yu, Tom Z Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire

Journal: Cell Rep

PubMed ID: 36681898

Doi: 10.1016/j.celrep.2023.112014

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Genetic diversity of Newcastle disease viruses circulating in wild and synanthropic birds in Ukraine between 2006 and 2015

Authors: Iryna V Goraichuk, Anton Gerilovych, Vitaliy Bolotin, Olexii Solodiankin, Kiril M Dimitrov, Oleksandr Rula, Nataliia Muzyka, Oleksandr Mezinov, Borys Stegniy, Olena Kolesnyk, Mary J Pantin-Jackwood, Patti J Miller, Claudio L Afonso, Denys Muzyka

Journal: Front Vet Sci

PubMed ID: 36742982

Doi: 10.3389/fvets.2023.1026296

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Nanoparticle vaccines can be designed to induce pDC support of mDCs for increased antigen display

Authors: Nina Butkovich, Jo Anne Tucker, Aaron Ramirez, Enya Li, Vijaykumar S Meli, Edward L Nelson, Szu-Wen Wang

Journal: Biomater Sci

PubMed ID: 36476811

Doi: 10.1039/d2bm01132h

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Development of a Competitive Enzyme-Linked Immunosorbent Assay Targeting the-p30 Protein for Detection of Antibodies against African Swine Fever Virus

Authors: Junming Zhou, Yanxiu Ni, Dandan Wang, Baochao Fan, Xuejiao Zhu, Jinzhu Zhou, Yiyi Hu, Li Li, Bin Li

Journal: Viruses

PubMed ID: 36680193

Doi: 10.3390/v15010154

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Potential Protective Function of Aβ Monomer on Tauopathies

Authors: Amber L H Gray, Victoria Norman, Damilola S Oluwatoba, Rebecca A Prosser, Thanh D Do

Journal: J Am Soc Mass Spectrom

PubMed ID: 36693165

Doi: 10.1021/jasms.2c00343

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Comparative analysis of allergenicity and predicted linear epitopes in α and β parvalbumin from turbot (Scophthalmus maximus)

Authors: Yuhao Huang, Zhenxing Li, Yeting Wu, Yonghong Li, Siddanakoppalu Pramod, Guanzhi Chen, Wenjia Zhu, Ziye Zhang, Hao Wang, Hong Lin

Journal: J Sci Food Agric

PubMed ID: 36606403

Doi: 10.1002/jsfa.12432

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Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Authors: Wajd N Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel Gw Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M Muraszko, Theodore S Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla

Journal: Neoplasia

PubMed ID: 36621024

Doi: 10.1016/j.neo.2022.100872

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MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma

Authors: Laura S Danielson, Maria V Guijarro, Silvia Menendez, Brett Higgins, Qiang Sun, Khushbakhat Mittal, Dorota A Popiolek, Michael Overholtzer, Glyn D Palmer, Eva Hernando

Journal: PLoS ONE

PubMed ID: 36701370

Doi: 10.1371/journal.pone.0278844

Products & Services: Molecular Biology Reagents

Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Authors: Weam S Shahin, Shima O Ebed, Scott R Tyler, Branko Miljkovic, Soon H Choi, Yulong Zhang, Weihong Zhou, Idil A Evans, Charles Yeaman, John F Engelhardt

Journal: Nat Commun

PubMed ID: 36707536

Doi: 10.1038/s41467-023-36174-z

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ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity

Authors: Gangadhar P Vadla, Sara M Ricardez Hernandez, Jiude Mao, Mona O Garro-Kacher, Zachary C Lorson, Ronin P Rice, Sarah A Hansen, Christian L Lorson, Kamal Singh, Monique A Lorson

Journal: JCI Insight

PubMed ID: 36480289

Doi: 10.1172/jci.insight.164608

Products & Services: Molecular Biology Reagents

Differentially Expressed Genes and Signalling Pathways Regulated by High Selenium Involved in Antioxidant and Immune Functions of Goats Based on Transcriptome Sequencing

Authors: Xu Wang, Chao Ban, Jia-Xuan Li, Qing-Yuan Luo, Ji-Xiao Qin, Yi-Qing Xu, Qi Lu, Xing-Zhou Tian

Journal: Int J Mol Sci

PubMed ID: 36674636

Doi: 10.3390/ijms24021124

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Ligand-dependent protein interactions of the juvenile hormone receptor captured in real time

Authors: Sarka Tumova, Marek Jindra

Journal: FEBS J

PubMed ID: 36609881

Doi: 10.1111/febs.16719

Products & Services: Molecular Biology Reagents

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Authors: Jack T Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A Tamming, Giuseppe Pugliese, Nikolas T Martin, Mathieu J F Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E F Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S Huh, Matt Y Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D Lichty, Carolina S Ilkow, John C Bell

Journal: Front Immunol

PubMed ID: 36713447

Doi: 10.3389/fimmu.2022.1050250

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Discovery and validation of new Hv1 proton channel inhibitors with onco-therapeutic potential

Authors: Antoun El Chemaly, Vincent Jaquet, Yves Cambet, Aurélie Caillon, Ophélie Cherpin, Alexia Balafa, Karl-Heinz Krause, Nicolas Demaurex

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36640925

Doi: 10.1016/j.bbamcr.2022.119415

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His-tagged lactate oxidase production for industrial applications using fed-batch fermentation

Authors: Agustina Godino, Marilla Amaranto, Agustina Manassero, Fausto Comba, Martín Alonzo Pérez, Lucio Simonella, Martín Pernigotti, José L Barra

Journal: J Biotechnol

PubMed ID: 36608873

Doi: 10.1016/j.jbiotec.2022.12.011

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Protective Effects of against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles

Authors: Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng

Journal: Int J Mol Sci

PubMed ID: 36768377

Doi: 10.3390/ijms24032053

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Generation of RUNX1c-eGFP induced pluripotent stem cell, MUSIi012-A-4, using CRISPR/Cas9

Authors: Pimonwan Srisook, Chuti Laowtammathron, Chanchao Lorthongpanich, Phatchanat Klaihmon, Papussorn Terbto, Supaporn Waeteekul, Yaowalak U-Pratya, Surapol Issaragrisil

Journal: Stem Cell Res

PubMed ID: 36753833

Doi: 10.1016/j.scr.2023.103035

Products & Services: Gene Synthesis

Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation

Authors: Pedro Madrigal, Siwei Deng, Yuliang Feng, Stefania Militi, Kim Jee Goh, Reshma Nibhani, Rodrigo Grandy, Anna Osnato, Daniel Ortmann, Stephanie Brown, Siim Pauklin

Journal: Nat Commun

PubMed ID: 36697417

Doi: 10.1038/s41467-023-36116-9

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Changes in Gene Chromatin Organization during Odontogenic Lineage Specification

Authors: Gokul Gopinathan, Xinmin Zhang, Xianghong Luan, Thomas G H Diekwisch

Journal: Genes (Basel)

PubMed ID: 36672939

Doi: 10.3390/genes14010198

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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Authors: View ORCID ProfileMartin S. Taylor, Connie Wu, Peter C. Fridy, Yasmeen Senussi, Wen-Chih Cheng, John Heaps, Kei Mori, Limor Cohen, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, View ORCID ProfileDavid R. Walt, View ORCID ProfileKathleen H. Burns

Journal: biorxiv

Doi: 10.1101/2023.01.25.525462

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SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway

Authors: Linlin Cai , Yunting Xie , Liangting Shao , Haijing Hu , Xinglian Xu , Huhu Wang , Guanghong Zhou

Journal: Gut Microbes .

PubMed ID: 37158502

Doi: 10.1080/19490976.2023.2211184

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Hyaluronate decorated polyethylene glycol linked poly(lactide-co-glycolide) nanoparticles encapsulating MUC-1 peptide augmented mucosal immune response in Balb/c mice through inhalation route

Authors: Kiran Jyoti, Garima Malik, Monika Chaudhary, Jitender Madan, Anjoo Kamboj

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 36731729

Doi: 10.1016/j.bbagen.2023.130317

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Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates

Authors: Yuanyuan Zhang, Xinyu Zhao, Xiaona Dong, Yuying Zhang, Haixia Zou, Yaoguang Jin, Wei Guo, Peng Zhai, Xu Chen, Alexei Kharitonenkov

Journal: Cell Metab

PubMed ID: 36706758

Doi: 10.1016/j.cmet.2023.01.001

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BML-111, the agonist of lipoxin A4, suppresses epithelial-mesenchymal transition and migration of MCF-7 cells regulating the lipoxygenase pathway

Authors: Fen Xu, Xiaoyan Zhou, Lan Lin, Jing Xu, Yu Feng, Yuanqiao He, Hua Hao

Journal: Int J Immunopathol Pharmacol

PubMed ID: 38134963

Doi: 10.1177/03946320231223826

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Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody

Authors: Anna Basile , Carla Zannella , Margot De Marco , Giuseppina Sanna , Gianluigi Franci , Massimiliano Galdiero , Aldo Manzin , Vincenzo De Laurenzi , Massimiliano Chetta , Alessandra Rosati , Maria Caterina Turco , Liberato Marzullo

Journal: Antiviral Res

PubMed ID: 36669656

Doi: 10.1016/j.antiviral.2023.105546

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Structure of monkeypox virus DNA polymerase holoenzyme

Authors: Qi Peng, Yufeng Xie, Lu Kuai, Han Wang, Jianxun Qi, George F Gao, Yi Shi

Journal: Science (New York, N. Y.)

PubMed ID: 36520947

Doi: 10.1126/science.ade6360

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Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47

Authors: Huanhuan Hu, Rongjie Cheng, Yanbo Wang, Xiaojun Wang, Jianzhuang Wu, Yan Kong, Shoubin Zhan, Zhen Zhou, Hongyu Zhu, Ranran Yu, Gaoli Liang, Qingyan Wang, Xiaoju Zhu, Chen-Yu Zhang, Rong Yin, Chao Yan , Xi Chen

Journal: The Journal of clinical investigation

PubMed ID: 36413402

Doi: 10.1172/JCI153470

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α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents

Authors: Kaiming Cao , Yang Zhu , Zhuanghao Hou , Manman Liu , Yanyan Yang , Hongze Hu , Yi Dai , Yu Wang , Siming Yuan , Guangming Huang , Jiaming Mei , Peter J Sadler , Yangzhong Liu

Journal: Angew Chem Int Ed Engl .

PubMed ID: 36345707

Doi: 10.1002/anie.202215360

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Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model

Authors: Daria S Chulpanova , Tamara V Pukhalskaia , Zarema E Gilazieva , Yuliya V Filina 1, Milana N Mansurova 1, Albert A Rizvanov 1, Valeriya V Solovyeva

Journal: Curr Issues Mol Biol .

PubMed ID: 36661524

Doi: 10.3390/cimb45010038

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Comprehensive Comparison of Seven SARS-CoV-2-Specific Surrogate Virus Neutralization and Anti-Spike IgG Antibody Assays Using a Live-Virus Neutralization Assay as a Reference

Authors: Marianne Graninger, Claudia Maria Jani, Elisabeth Reuberger, Katja Prüger, Philipp Gaspar, David Niklas Springer, Christian Borsodi, Lisa Weidner, Susanne Rabady, Elisabeth Puchhammer-Stöckl, Christof Jungbauer, Eva Höltl, Judith Helene Aberle, Karin Stiasny, Lukas Weseslindtner

Journal: Microbiol Spectr

PubMed ID: 36622205

Doi: 10.1128/spectrum.02314-22

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The FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin's lymphoma tumor growth by promoting apoptosis and autophagy

Authors: Yan Lv, Yuxin Du, Kening Li, Xiao Ma, Juan Wang, Tongde Du, Yuxin Ma, Yue Teng, Weiyan Tang, Rong Ma, Jianqiu Wu, Jianzhong Wu, Jifeng Feng

Journal: Cell Commun Signal

PubMed ID: 36691066

Doi: 10.1186/s12964-022-01031-x

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Functions of human olfactory mucus and age-dependent changes

Authors: Tomohiro Shirai, Dan Takase, Junkichi Yokoyama, Kuniyuki Nakanishi, Chisaki Uehara, Naoko Saito, Aya Kato-Namba, Keiichi Yoshikawa